GPA33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)9.48814100
2intestinal cholesterol absorption (GO:0030299)8.09818649
3intestinal epithelial cell development (GO:0060576)7.65136040
4regulation of guanylate cyclase activity (GO:0031282)7.26077468
5angiotensin maturation (GO:0002003)6.41928899
6bundle of His cell to Purkinje myocyte communication (GO:0086069)6.34911090
7UDP-N-acetylglucosamine metabolic process (GO:0006047)6.17111077
8vitamin A metabolic process (GO:0006776)6.11054841
9maintenance of gastrointestinal epithelium (GO:0030277)6.04938154
10positive regulation of respiratory burst (GO:0060267)5.64421411
11NADH metabolic process (GO:0006734)5.62314578
12positive regulation of guanylate cyclase activity (GO:0031284)5.29950961
13epoxygenase P450 pathway (GO:0019373)5.20303110
14regulation of systemic arterial blood pressure by hormone (GO:0001990)5.17757986
15regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.17757986
16endocrine process (GO:0050886)5.17757986
17actin filament depolymerization (GO:0030042)5.13187370
18fat-soluble vitamin biosynthetic process (GO:0042362)4.98559869
19regulation of cellular extravasation (GO:0002691)4.97371343
20cellular glucuronidation (GO:0052695)4.91912949
21sulfate transmembrane transport (GO:1902358)4.85163940
22trophectodermal cell differentiation (GO:0001829)4.82965460
23flavonoid metabolic process (GO:0009812)4.82108606
24glucuronate metabolic process (GO:0019585)4.77561036
25uronic acid metabolic process (GO:0006063)4.77561036
26epithelial structure maintenance (GO:0010669)4.77150665
27lipoprotein transport (GO:0042953)4.77115915
28renal system process involved in regulation of blood volume (GO:0001977)4.76750829
29digestive system process (GO:0022600)4.71137583
30regulation of systemic arterial blood pressure (GO:0003073)4.60456576
31purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.58185953
323-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.58185953
33regulation of vitamin metabolic process (GO:0030656)4.55800926
34hemidesmosome assembly (GO:0031581)4.45425216
35response to hepatocyte growth factor (GO:0035728)4.38124323
36cellular response to hepatocyte growth factor stimulus (GO:0035729)4.38124323
37glomerular filtration (GO:0003094)4.37983701
38regulation of cGMP biosynthetic process (GO:0030826)4.35968557
39O-glycan processing (GO:0016266)4.33854143
40GDP-mannose metabolic process (GO:0019673)4.25841311
41nucleotide-sugar biosynthetic process (GO:0009226)4.22511411
42sulfate transport (GO:0008272)4.20434065
43proline biosynthetic process (GO:0006561)4.18355436
44regulation of respiratory burst (GO:0060263)4.11188682
45regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.04821152
46diacylglycerol metabolic process (GO:0046339)4.04791475
47oligosaccharide biosynthetic process (GO:0009312)4.01906554
48antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.01493107
49renal filtration (GO:0097205)3.97473720
50sulfur compound transport (GO:0072348)3.97152892
51antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.96884044
52virion attachment to host cell (GO:0019062)3.92604549
53adhesion of symbiont to host cell (GO:0044650)3.92604549
54urea cycle (GO:0000050)3.91738236
55drug metabolic process (GO:0017144)3.90125492
56regulation of pseudopodium assembly (GO:0031272)3.86344962
57sulfation (GO:0051923)3.79762060
58modified amino acid transport (GO:0072337)3.77998278
59regulation of cholesterol homeostasis (GO:2000188)3.74478025
60regulation of bile acid biosynthetic process (GO:0070857)3.72954386
61antigen processing and presentation of endogenous antigen (GO:0019883)3.72758570
62ethanol oxidation (GO:0006069)3.72307337
63fructose metabolic process (GO:0006000)3.71238011
64anterior/posterior axis specification, embryo (GO:0008595)3.69369068
65urea metabolic process (GO:0019627)3.69309532
66regulation of viral release from host cell (GO:1902186)3.64430126
67epithelial cell-cell adhesion (GO:0090136)3.62550384
68glycosphingolipid catabolic process (GO:0046479)3.58485051
69regulation of cGMP metabolic process (GO:0030823)3.57176932
70drug catabolic process (GO:0042737)3.56397906
71glycolipid catabolic process (GO:0019377)3.52510097
72cGMP-mediated signaling (GO:0019934)3.51582144
73positive regulation of fatty acid beta-oxidation (GO:0032000)3.49995483
74hepatocyte apoptotic process (GO:0097284)3.49041477
75nucleoside diphosphate biosynthetic process (GO:0009133)3.48119486
76sulfur amino acid catabolic process (GO:0000098)3.47125550
77interferon-gamma secretion (GO:0072643)3.44312083
78peptide catabolic process (GO:0043171)3.40894128
79nitrogen cycle metabolic process (GO:0071941)3.40795951
80thyroid hormone metabolic process (GO:0042403)3.40436479
81bile acid and bile salt transport (GO:0015721)3.39275930
82cell differentiation involved in embryonic placenta development (GO:0060706)3.36734183
83antimicrobial humoral response (GO:0019730)3.36337869
84renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.35379734
85digestion (GO:0007586)3.29849576
86phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.29677636
87regulation of chemokine secretion (GO:0090196)3.29550056
88transcytosis (GO:0045056)3.29289216
89peptide hormone processing (GO:0016486)3.26417924
90calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.25035263
91nucleotide-sugar metabolic process (GO:0009225)3.24998234
92glucocorticoid biosynthetic process (GO:0006704)3.24994669
93antibacterial humoral response (GO:0019731)3.24735948
94bicarbonate transport (GO:0015701)3.24398471
95branching involved in labyrinthine layer morphogenesis (GO:0060670)3.23837213
96columnar/cuboidal epithelial cell development (GO:0002066)3.22232745
97galactose catabolic process (GO:0019388)3.20964982
98hormone catabolic process (GO:0042447)3.20902115
99regulation of integrin activation (GO:0033623)3.19986968
100fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.19117222
101positive regulation of glycoprotein biosynthetic process (GO:0010560)3.19022129
102positive regulation of Cdc42 GTPase activity (GO:0043089)3.16433317
103auditory receptor cell differentiation (GO:0042491)3.11417473
104positive regulation of lipid catabolic process (GO:0050996)3.08026398
105glycosylceramide metabolic process (GO:0006677)3.07332860
106desmosome organization (GO:0002934)3.04932115
107positive regulation of T cell differentiation in thymus (GO:0033089)3.04016794
108adhesion of symbiont to host (GO:0044406)3.00812504
109proline metabolic process (GO:0006560)3.00003817
110positive regulation of cGMP biosynthetic process (GO:0030828)2.99996307
111drug transport (GO:0015893)2.98610070
112heterochromatin organization (GO:0070828)2.98271872
113arginine metabolic process (GO:0006525)2.97973242
114positive regulation of glycoprotein metabolic process (GO:1903020)2.97344590
115nucleotide salvage (GO:0043173)2.97060022
116tight junction assembly (GO:0070830)2.96790313
117regulation of triglyceride catabolic process (GO:0010896)2.93979022
118cGMP biosynthetic process (GO:0006182)2.93344792
119sperm capacitation (GO:0048240)2.92794958
120negative regulation of sterol transport (GO:0032372)2.92001305
121negative regulation of cholesterol transport (GO:0032375)2.92001305
122ventricular cardiac muscle cell action potential (GO:0086005)2.91583934
123glucose 6-phosphate metabolic process (GO:0051156)2.90490644
124drug transmembrane transport (GO:0006855)2.89944033
125vitamin transmembrane transport (GO:0035461)2.88885998
126regulation of posttranscriptional gene silencing (GO:0060147)2.88844782
127regulation of gene silencing by miRNA (GO:0060964)2.88844782
128regulation of gene silencing by RNA (GO:0060966)2.88844782
129alkaloid metabolic process (GO:0009820)2.88211413
130very-low-density lipoprotein particle assembly (GO:0034379)2.88150421
131plasma lipoprotein particle assembly (GO:0034377)2.88050003
132sodium ion homeostasis (GO:0055078)2.86229103
133ethanol metabolic process (GO:0006067)2.85571882
134glycerol metabolic process (GO:0006071)2.85288107
135antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.85244873
136establishment of apical/basal cell polarity (GO:0035089)2.84506797
137ceramide catabolic process (GO:0046514)2.83950370
138labyrinthine layer development (GO:0060711)2.83477968
139positive regulation of epidermal cell differentiation (GO:0045606)2.82974875
140positive regulation of pseudopodium assembly (GO:0031274)2.82541483
141sphingolipid catabolic process (GO:0030149)2.82529526
142thrombin receptor signaling pathway (GO:0070493)2.81142731
143sexual reproduction (GO:0019953)2.80773636
144activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.80729214
145lipoprotein metabolic process (GO:0042157)2.76707041
146striated muscle atrophy (GO:0014891)2.76532141
147hypotonic response (GO:0006971)2.75397064
148regulation of actin nucleation (GO:0051125)2.74959575
149branching involved in mammary gland duct morphogenesis (GO:0060444)2.73505694
150sphingomyelin metabolic process (GO:0006684)2.71975524
151pyrimidine-containing compound transmembrane transport (GO:0072531)2.68771386
152negative regulation of keratinocyte proliferation (GO:0010839)2.68756478
153protein-lipid complex assembly (GO:0065005)2.67884513
154protein O-linked glycosylation (GO:0006493)2.67622599
155positive regulation of actin filament depolymerization (GO:0030836)2.67390542
156receptor guanylyl cyclase signaling pathway (GO:0007168)2.67259776
157apoptotic process involved in morphogenesis (GO:0060561)2.61665448
158cholesterol homeostasis (GO:0042632)2.60095135
159sterol homeostasis (GO:0055092)2.60006093
160phospholipid scrambling (GO:0017121)2.59568037
161activation of Rac GTPase activity (GO:0032863)2.59363187
162transepithelial transport (GO:0070633)2.58690969
163embryonic process involved in female pregnancy (GO:0060136)2.57649029
164phospholipid efflux (GO:0033700)2.54658914
165regulation of sister chromatid cohesion (GO:0007063)2.52761139

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.89245577
2* CDX2_20551321_ChIP-Seq_CACO-2_Human4.04238271
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.99841233
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.59967432
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.59967432
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.59967432
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.17854594
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.17083503
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.07636189
10SOX2_27498859_Chip-Seq_STOMACH_Mouse3.03986039
11* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.85507545
12* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.68928398
13* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.66025559
14ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.56233784
15GATA6_25053715_ChIP-Seq_YYC3_Human2.50279166
16* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.50263007
17* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.47297352
18* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.40525629
19E2F7_22180533_ChIP-Seq_HELA_Human2.38236497
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.32228656
21* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.28117032
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.25242331
23GATA4_25053715_ChIP-Seq_YYC3_Human2.22442997
24* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.16795120
25STAT3_1855785_ChIP-Seq_MESCs_Mouse2.15260860
26* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.06236235
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.04861086
28CDX2_19796622_ChIP-Seq_MESCs_Mouse2.00966932
29SRY_22984422_ChIP-ChIP_TESTIS_Rat2.00733193
30HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.00619398
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.96713542
32ZNF263_19887448_ChIP-Seq_K562_Human1.89615232
33* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.85581812
34CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.82876118
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.82042021
36* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.80681837
37RACK7_27058665_Chip-Seq_MCF-7_Human1.77486947
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.76987088
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.76403406
40SOX2_20726797_ChIP-Seq_SW620_Human1.71169777
41FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.70405868
42PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.67971428
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65015461
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61760816
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.60884963
46ATF3_27146783_Chip-Seq_COLON_Human1.60730107
47* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.60411171
48SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.57552095
49* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.56261797
50* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.55696254
51* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.55414729
52SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.55326140
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55182824
54AR_21909140_ChIP-Seq_LNCAP_Human1.54991274
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53818285
56RUNX1_27514584_Chip-Seq_MCF-7_Human1.50805070
57* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.49088990
58TCF4_18268006_ChIP-ChIP_LS174T_Human1.48334382
59AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.46832833
60PPARA_22158963_ChIP-Seq_LIVER_Mouse1.46668377
61BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.45953848
62KLF5_25053715_ChIP-Seq_YYC3_Human1.41517905
63* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.41415913
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.40760706
65* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40732090
66STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.36642516
67IRF8_21731497_ChIP-ChIP_J774_Mouse1.35071542
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.32493887
69ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32064133
70* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.31127615
71CLOCK_20551151_ChIP-Seq_293T_Human1.28496626
72* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.28117210
73FOXM1_23109430_ChIP-Seq_U2OS_Human1.26306029
74EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.25736127
75KAP1_27257070_Chip-Seq_ESCs_Mouse1.24833702
76ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24388629
77* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.23693414
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.22917178
79FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.22223700
80GATA1_19941826_ChIP-Seq_K562_Human1.21381848
81MYC_18555785_ChIP-Seq_MESCs_Mouse1.20671007
82* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.20300380
83GATA2_19941826_ChIP-Seq_K562_Human1.19974078
84FOXA1_25552417_ChIP-Seq_VCAP_Human1.18741497
85DROSHA_22980978_ChIP-Seq_HELA_Human1.18359233
86ESR1_21235772_ChIP-Seq_MCF-7_Human1.17647501
87VDR_24763502_ChIP-Seq_THP-1_Human1.17578530
88RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17416932
89P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16042303
90GATA1_22025678_ChIP-Seq_K562_Human1.15737160
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15640632
92BCL6_27268052_Chip-Seq_Bcells_Human1.15042412
93CREB1_26743006_Chip-Seq_LNCaP_Human1.14822166
94TRIM28_21343339_ChIP-Seq_HEK293_Human1.14795516
95SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14139008
96NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13956878
97TET1_21451524_ChIP-Seq_MESCs_Mouse1.13422043
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13396666
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12958750
100ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12850141
101CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11890062
102* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11781926
103FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.11229906
104HNF4A_19822575_ChIP-Seq_HepG2_Human1.10100653
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09575493
106STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08154219
107LXR_22292898_ChIP-Seq_THP-1_Human1.08016101
108SA1_27219007_Chip-Seq_Bcells_Human1.07903107
109* CDX2_22108803_ChIP-Seq_LS180_Human1.07291978
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07232022
111* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.06298032
112PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.05510791
113CEBPB_22108803_ChIP-Seq_LS180_Human1.05100318
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05041417
115PHF8_20622854_ChIP-Seq_HELA_Human1.03489195
116IRF8_27001747_Chip-Seq_BMDM_Mouse1.02407017
117EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.02004362
118STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00708565
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99894587
120PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99170163
121ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98854313
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97882707
123EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97706221
124* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97584333
125NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97562123
126NANOG_21062744_ChIP-ChIP_HESCs_Human0.97278944
127TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96210954
128FOXA2_19822575_ChIP-Seq_HepG2_Human0.95929308
129RXR_22158963_ChIP-Seq_LIVER_Mouse0.95911951
130* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94659930
131SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94572644
132EGR1_19032775_ChIP-ChIP_M12_Human0.93461555
133E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93123074
134TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91237001
135FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90744483
136FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90576734
137CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89809585
138SALL1_21062744_ChIP-ChIP_HESCs_Human0.89734293
139PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87831893
140NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87129709
141NANOG_20526341_ChIP-Seq_ESCs_Human0.86089137
142PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85948259
143LXR_22158963_ChIP-Seq_LIVER_Mouse0.85459943
144* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.84953016
145TP63_22573176_ChIP-Seq_HFKS_Human0.84271371
146P68_20966046_ChIP-Seq_HELA_Human0.83425023
147RARA_24833708_ChIP-Seq_LIVER_Mouse0.83406260
148ETS1_21867929_ChIP-Seq_TH2_Mouse0.83195367
149VDR_24787735_ChIP-Seq_THP-1_Human0.82876710
150SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82780858
151ELK3_25401928_ChIP-Seq_HUVEC_Human0.82495058
152P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82055675
153BCOR_27268052_Chip-Seq_Bcells_Human0.81817839
154ZFP281_18757296_ChIP-ChIP_E14_Mouse0.81689219
155DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81675319
156GATA1_26923725_Chip-Seq_HPCs_Mouse0.81643257
157* VDR_21846776_ChIP-Seq_THP-1_Human0.81589116
158FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80375730
159UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.80342532
160CTCF_27219007_Chip-Seq_Bcells_Human0.80265350

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.48192972
2MP0004264_abnormal_extraembryonic_tissu5.15198099
3MP0005360_urolithiasis5.04009500
4MP0001666_abnormal_nutrient_absorption4.06363509
5MP0000462_abnormal_digestive_system3.77525592
6MP0003866_abnormal_defecation3.54231800
7MP0010352_gastrointestinal_tract_polyps3.52126990
8MP0003283_abnormal_digestive_organ3.07567554
9MP0000537_abnormal_urethra_morphology2.84893723
10MP0000490_abnormal_crypts_of2.79293556
11MP0003705_abnormal_hypodermis_morpholog2.53223937
12MP0010155_abnormal_intestine_physiology2.47359874
13MP0000477_abnormal_intestine_morphology2.41065625
14MP0005085_abnormal_gallbladder_physiolo2.37156961
15MP0001873_stomach_inflammation2.32959133
16MP0005381_digestive/alimentary_phenotyp2.31844797
17MP0003878_abnormal_ear_physiology2.26730474
18MP0005377_hearing/vestibular/ear_phenot2.26730474
19MP0001663_abnormal_digestive_system2.25587526
20MP0001849_ear_inflammation2.14554381
21MP0009840_abnormal_foam_cell2.08324775
22MP0003693_abnormal_embryo_hatching2.05641789
23MP0004957_abnormal_blastocyst_morpholog1.96176694
24MP0005409_darkened_coat_color1.95971313
25MP0002796_impaired_skin_barrier1.93177059
26MP0002822_catalepsy1.91919405
27MP0003806_abnormal_nucleotide_metabolis1.85732191
28MP0001664_abnormal_digestion1.80886731
29MP0003252_abnormal_bile_duct1.80504717
30MP0008875_abnormal_xenobiotic_pharmacok1.65857747
31MP0003453_abnormal_keratinocyte_physiol1.60499744
32MP0000516_abnormal_urinary_system1.59324595
33MP0005367_renal/urinary_system_phenotyp1.59324595
34MP0003724_increased_susceptibility_to1.54762048
35MP0005636_abnormal_mineral_homeostasis1.50067252
36MP0005670_abnormal_white_adipose1.49531585
37MP0005501_abnormal_skin_physiology1.48726261
38MP0000467_abnormal_esophagus_morphology1.47485722
39MP0002138_abnormal_hepatobiliary_system1.43299430
40MP0003183_abnormal_peptide_metabolism1.42951712
41MP0003300_gastrointestinal_ulcer1.41015651
42MP0004019_abnormal_vitamin_homeostasis1.39944110
43MP0004782_abnormal_surfactant_physiolog1.39280191
44MP0004043_abnormal_pH_regulation1.37898739
45MP0000470_abnormal_stomach_morphology1.36554012
46MP0005167_abnormal_blood-brain_barrier1.36277821
47MP0003119_abnormal_digestive_system1.35947069
48MP0000465_gastrointestinal_hemorrhage1.34234776
49MP0002139_abnormal_hepatobiliary_system1.29391390
50MP0000538_abnormal_urinary_bladder1.28661629
51MP0005332_abnormal_amino_acid1.28422119
52MP0003303_peritoneal_inflammation1.24749765
53MP0004858_abnormal_nervous_system1.24327651
54MP0002876_abnormal_thyroid_physiology1.24144117
55MP0002136_abnormal_kidney_physiology1.21345417
56MP0005451_abnormal_body_composition1.20026986
57MP0002254_reproductive_system_inflammat1.19450127
58MP0001764_abnormal_homeostasis1.18836081
59MP0010678_abnormal_skin_adnexa1.18067040
60MP0001188_hyperpigmentation1.16178479
61MP0009785_altered_susceptibility_to1.15926551
62MP0003315_abnormal_perineum_morphology1.15521952
63MP0003718_maternal_effect1.14946596
64MP0003941_abnormal_skin_development1.14714501
65MP0002166_altered_tumor_susceptibility1.13124258
66MP0010329_abnormal_lipoprotein_level1.11894523
67MP0006054_spinal_hemorrhage1.10728179
68MP0005365_abnormal_bile_salt1.10716950
69MP0003436_decreased_susceptibility_to1.06428158
70MP0002653_abnormal_ependyma_morphology1.05952580
71MP0003879_abnormal_hair_cell1.05599015
72MP0002277_abnormal_respiratory_mucosa1.05410050
73MP0002086_abnormal_extraembryonic_tissu1.04724632
74MP0005025_abnormal_response_to1.04721977
75MP0005266_abnormal_metabolism1.04417107
76MP0001845_abnormal_inflammatory_respons1.03358241
77MP0008004_abnormal_stomach_pH1.02648604
78MP0002098_abnormal_vibrissa_morphology1.01988480
79MP0000678_abnormal_parathyroid_gland1.00830755
80MP0000230_abnormal_systemic_arterial0.99367743
81MP0001730_embryonic_growth_arrest0.99213077
82MP0002118_abnormal_lipid_homeostasis0.98731458
83MP0005076_abnormal_cell_differentiation0.98151680
84MP0001835_abnormal_antigen_presentation0.97189347
85MP0009053_abnormal_anal_canal0.95737396
86MP0001756_abnormal_urination0.93380165
87MP0010030_abnormal_orbit_morphology0.91281673
88MP0005387_immune_system_phenotype0.90380361
89MP0001790_abnormal_immune_system0.90380361
90MP0008057_abnormal_DNA_replication0.90327476
91MP0001216_abnormal_epidermal_layer0.89668185
92MP0006082_CNS_inflammation0.89527933
93MP0009333_abnormal_splenocyte_physiolog0.88244045
94MP0009379_abnormal_foot_pigmentation0.86821851
95MP0003566_abnormal_cell_adhesion0.84623433
96MP0008872_abnormal_physiological_respon0.84419651
97MP0005319_abnormal_enzyme/_coenzyme0.84084770
98MP0009643_abnormal_urine_homeostasis0.83852140
99MP0001501_abnormal_sleep_pattern0.82925996
100MP0000762_abnormal_tongue_morphology0.82577420
101MP0002971_abnormal_brown_adipose0.82491782
102MP0000350_abnormal_cell_proliferation0.81126718
103MP0002006_tumorigenesis0.81006958
104MP0005023_abnormal_wound_healing0.80483165
105MP0005584_abnormal_enzyme/coenzyme_acti0.79727123
106MP0002009_preneoplasia0.79464484
107MP0001800_abnormal_humoral_immune0.79223326
108MP0002060_abnormal_skin_morphology0.77053715
109MP0002085_abnormal_embryonic_tissue0.76729639
110MP0010307_abnormal_tumor_latency0.76597089
111MP0009115_abnormal_fat_cell0.74642888
112MP0004947_skin_inflammation0.74233343
113MP0004147_increased_porphyrin_level0.73967874
114MP0005666_abnormal_adipose_tissue0.73757749
115MP0002148_abnormal_hypersensitivity_rea0.73619563
116MP0001672_abnormal_embryogenesis/_devel0.72870606
117MP0005380_embryogenesis_phenotype0.72870606
118MP0002396_abnormal_hematopoietic_system0.72810087
119MP0008469_abnormal_protein_level0.72502959
120MP0001765_abnormal_ion_homeostasis0.72361238
121MP0000613_abnormal_salivary_gland0.69715124
122MP0001533_abnormal_skeleton_physiology0.68591182
123MP0005310_abnormal_salivary_gland0.68090685
124MP0002084_abnormal_developmental_patter0.67922037
125MP0005671_abnormal_response_to0.67327998
126MP0005535_abnormal_body_temperature0.67123739
127MP0005448_abnormal_energy_balance0.66375632
128MP0005058_abnormal_lysosome_morphology0.64884952
129MP0001697_abnormal_embryo_size0.63541375
130MP0002896_abnormal_bone_mineralization0.63014451
131MP0000249_abnormal_blood_vessel0.62734982
132MP0009642_abnormal_blood_homeostasis0.62363813
133MP0003329_amyloid_beta_deposits0.61909086
134MP0003111_abnormal_nucleus_morphology0.61240478
135MP0005165_increased_susceptibility_to0.60743433
136MP0001485_abnormal_pinna_reflex0.59535941
137MP0005166_decreased_susceptibility_to0.59336984
138MP0003984_embryonic_growth_retardation0.59195771
139MP0002089_abnormal_postnatal_growth/wei0.59092937
140MP0000609_abnormal_liver_physiology0.58624560
141MP0004185_abnormal_adipocyte_glucose0.58497422
142MP0002452_abnormal_antigen_presenting0.57732581
143MP0002088_abnormal_embryonic_growth/wei0.57202061
144MP0005000_abnormal_immune_tolerance0.56625157
145MP0002998_abnormal_bone_remodeling0.55935623
146MP0003950_abnormal_plasma_membrane0.55459277
147MP0000604_amyloidosis0.55454566
148MP0002111_abnormal_tail_morphology0.54043996
149MP0003045_fibrosis0.53246481
150MP0010771_integument_phenotype0.53058892
151MP0002080_prenatal_lethality0.52645342
152MP0003868_abnormal_feces_composition0.52636307
153MP0003191_abnormal_cellular_cholesterol0.51063289
154MP0000579_abnormal_nail_morphology0.50921517

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)7.42860942
2Right ventricular cardiomyopathy (HP:0011663)6.09314955
3Decreased circulating renin level (HP:0003351)5.85982956
4Malnutrition (HP:0004395)4.91393237
5Alkalosis (HP:0001948)4.48479043
6Abnormality of the 1st metacarpal (HP:0010009)4.28291666
7Pustule (HP:0200039)4.21161673
8Abnormality of glutamine family amino acid metabolism (HP:0010902)3.91077707
9Abnormality of vitamin B metabolism (HP:0004340)3.86642435
10Abdominal distention (HP:0003270)3.73887974
11Flat acetabular roof (HP:0003180)3.62218714
12Hyperactive renin-angiotensin system (HP:0000841)3.57348960
13Milia (HP:0001056)3.53603897
14Systemic lupus erythematosus (HP:0002725)3.52815167
15Hyperaldosteronism (HP:0000859)3.46254544
16Gastrointestinal dysmotility (HP:0002579)3.30572313
17Abnormality of small intestinal villus morphology (HP:0011472)3.28495498
18Villous atrophy (HP:0011473)3.28495498
19Eczematoid dermatitis (HP:0000976)3.24439175
20Short phalanx of the thumb (HP:0009660)3.19025868
21Hydroxyprolinuria (HP:0003080)3.18480725
22Abnormality of proline metabolism (HP:0010907)3.18480725
23Hemorrhage of the eye (HP:0011885)3.17556149
24Hypobetalipoproteinemia (HP:0003563)3.15469547
25Thin bony cortex (HP:0002753)3.15279550
26Abnormality of vitamin metabolism (HP:0100508)3.11296667
27Short humerus (HP:0005792)3.09438792
28Confusion (HP:0001289)3.09113288
29Fragile nails (HP:0001808)3.09060886
30Short 1st metacarpal (HP:0010034)3.05393281
31Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.05393281
32Pili torti (HP:0003777)3.05086073
33Biliary tract neoplasm (HP:0100574)3.04548031
34Abnormality of the distal phalanx of the thumb (HP:0009617)3.02051390
35Aplasia/hypoplasia of the humerus (HP:0006507)2.94040884
36Vertebral clefting (HP:0008428)2.91448861
37Woolly hair (HP:0002224)2.91405033
38Onycholysis (HP:0001806)2.88790658
39Abnormal biliary tract morphology (HP:0012440)2.85312234
40Mildly elevated creatine phosphokinase (HP:0008180)2.84848663
41Vertebral hypoplasia (HP:0008417)2.84807674
42Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.84807674
43Hypokalemia (HP:0002900)2.81570800
44Metabolic alkalosis (HP:0200114)2.80864280
45Cupped ribs (HP:0000887)2.80501418
46Acanthocytosis (HP:0001927)2.79272824
47Esophageal atresia (HP:0002032)2.77376342
48Abnormal tarsal ossification (HP:0008369)2.76670086
49Hyponatremia (HP:0002902)2.75506357
50Dehydration (HP:0001944)2.71453498
51Cheilitis (HP:0100825)2.63460900
52Alopecia of scalp (HP:0002293)2.63295605
53Widely patent fontanelles and sutures (HP:0004492)2.62864663
54Autoimmune thrombocytopenia (HP:0001973)2.62426500
55Conjugated hyperbilirubinemia (HP:0002908)2.60309219
56Wide cranial sutures (HP:0010537)2.59669816
57Plantar hyperkeratosis (HP:0007556)2.59061510
58Atrophic scars (HP:0001075)2.56653076
59Pigmentary retinal degeneration (HP:0001146)2.55908238
60Abnormality of potassium homeostasis (HP:0011042)2.55554957
61Abnormality of chloride homeostasis (HP:0011422)2.52727119
62Abnormality of the gastric mucosa (HP:0004295)2.49525393
63Micronodular cirrhosis (HP:0001413)2.47076053
64Chronic diarrhea (HP:0002028)2.46620104
65Progressive sensorineural hearing impairment (HP:0000408)2.46134837
66Ependymoma (HP:0002888)2.45821895
67Rib fusion (HP:0000902)2.44558987
68Rectal prolapse (HP:0002035)2.43451244
69Curly hair (HP:0002212)2.41541020
70Hyperammonemia (HP:0001987)2.40068321
71Glycosuria (HP:0003076)2.37166996
72Abnormality of urine glucose concentration (HP:0011016)2.37166996
73Hypotension (HP:0002615)2.35634938
74Hyperparathyroidism (HP:0000843)2.34067653
75Nausea (HP:0002018)2.33096433
76Ureteral stenosis (HP:0000071)2.33011182
77Xanthomatosis (HP:0000991)2.31515206
78Nephrolithiasis (HP:0000787)2.31339835
79Palpitations (HP:0001962)2.26686806
80Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.26369603
81Uterine neoplasm (HP:0010784)2.23989188
82Fat malabsorption (HP:0002630)2.23559219
83Focal segmental glomerulosclerosis (HP:0000097)2.21480592
84Enlarged epiphyses (HP:0010580)2.19607426
85Tongue fasciculations (HP:0001308)2.19487331
86Microretrognathia (HP:0000308)2.16930703
87Abnormality of carpal bone ossification (HP:0006257)2.16559950
88Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.14201227
89Proximal tubulopathy (HP:0000114)2.14165605
90Hypophosphatemia (HP:0002148)2.13714289
91Progressive hearing impairment (HP:0001730)2.13364332
92Petechiae (HP:0000967)2.11558167
93Gastrointestinal carcinoma (HP:0002672)2.11507210
94Malignant gastrointestinal tract tumors (HP:0006749)2.11507210
95Ureteral obstruction (HP:0006000)2.09848194
96Dicarboxylic aciduria (HP:0003215)2.08864446
97Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08864446
98Renal tubular acidosis (HP:0001947)2.07938470
99Myopathic facies (HP:0002058)2.06554972
100Abnormality of monocarboxylic acid metabolism (HP:0010996)2.04548855
101Abnormality of the phalanges of the hallux (HP:0010057)2.04486805
102Abnormality of renin-angiotensin system (HP:0000847)2.03312044
103Adrenal overactivity (HP:0002717)2.03026617
104Abnormality of sodium homeostasis (HP:0010931)2.02891161
105Shawl scrotum (HP:0000049)2.02808205
106Visceral angiomatosis (HP:0100761)2.02535871
107Neonatal short-limb short stature (HP:0008921)2.02338337
108Protuberant abdomen (HP:0001538)2.01371531
109Hyperglycinuria (HP:0003108)2.01239270
110Delayed epiphyseal ossification (HP:0002663)2.01103056
111Intrahepatic cholestasis (HP:0001406)2.01023532
112Trismus (HP:0000211)1.99928297
113Hyperuricemia (HP:0002149)1.99846994
114Increased purine levels (HP:0004368)1.99846994
115Abnormal hair laboratory examination (HP:0003328)1.99719431
116Proximal placement of thumb (HP:0009623)1.99671045
117Abnormal cartilage morphology (HP:0002763)1.99442924
118Abnormality of glycine metabolism (HP:0010895)1.99426497
119Abnormality of serine family amino acid metabolism (HP:0010894)1.99426497
120Hyperkalemia (HP:0002153)1.99143791
121Hyperphosphatemia (HP:0002905)1.99026442
122Deviation of the thumb (HP:0009603)1.98401243
123Posterior subcapsular cataract (HP:0007787)1.98246676
124Neoplasm of the rectum (HP:0100743)1.97780543
125Congenital sensorineural hearing impairment (HP:0008527)1.97703805
126Male infertility (HP:0003251)1.97612002
127Gingivitis (HP:0000230)1.96981976
128Abnormality of the costochondral junction (HP:0000919)1.96415116
129Ventricular tachycardia (HP:0004756)1.95034867
130Breast hypoplasia (HP:0003187)1.93261122
131Abnormal foot bone ossification (HP:0010675)1.92790102
132Growth hormone excess (HP:0000845)1.92075113
133Muscle fibrillation (HP:0010546)1.90955460
134Abnormality of the vitamin B12 metabolism (HP:0004341)1.90758151
135Rectovaginal fistula (HP:0000143)1.90408999
136Rectal fistula (HP:0100590)1.90408999
137Mesangial abnormality (HP:0001966)1.89034462
138Cerebral palsy (HP:0100021)1.88744794
139Steatorrhea (HP:0002570)1.88676445
140Abnormality of the astrocytes (HP:0100707)1.88197961
141Astrocytoma (HP:0009592)1.88197961
142Abnormality of complement system (HP:0005339)1.86592561
143Pancreatitis (HP:0001733)1.86470402
144Glomerulonephritis (HP:0000099)1.86207814
145Vaginal fistula (HP:0004320)1.86174130
146Flat capital femoral epiphysis (HP:0003370)1.85667506
147Symphalangism affecting the phalanges of the hand (HP:0009773)1.84936073
148Hypolipoproteinemia (HP:0010981)1.84430945
149Segmental peripheral demyelination/remyelination (HP:0003481)1.84402815
150Syncope (HP:0001279)1.84052277
151Flattened epiphyses (HP:0003071)1.83157408
152Hoarse voice (HP:0001609)1.82716667
153Gastrointestinal atresia (HP:0002589)1.82436324
154Potter facies (HP:0002009)1.82087843
155Facial shape deformation (HP:0011334)1.82087843
156Nail dystrophy (HP:0008404)1.81993788
157Metabolic acidosis (HP:0001942)1.80564260
158Nephritis (HP:0000123)1.78737803
159Bone pain (HP:0002653)1.78303299
160Megaloblastic anemia (HP:0001889)1.77073301
161Abnormality of magnesium homeostasis (HP:0004921)1.77017160
162Hemangiomatosis (HP:0007461)1.75536205
163Abnormality of purine metabolism (HP:0004352)1.75040337

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.38700059
2MST1R5.07899593
3EPHA24.47845772
4MST44.39749880
5FRK3.75445975
6LMTK23.59886129
7MAP2K22.96070318
8PRKG22.80278279
9NME12.44521965
10MET2.34521424
11ICK2.34262681
12DDR22.31129480
13AKT32.23211084
14GRK62.22701591
15CDK122.12900227
16STK392.07324072
17PIK3CA1.96524731
18MATK1.94415527
19RIPK11.94220085
20TTK1.83042455
21MAP3K101.78089312
22PRPF4B1.74252010
23FGFR41.73992237
24TESK11.66979171
25RIPK41.66785653
26EPHB21.64387981
27MAP4K11.63832355
28MAP3K21.59078474
29TYK21.59069107
30OXSR11.55748512
31PAK41.44345070
32MAP3K111.44284287
33PRKCI1.40249980
34PTK61.36819889
35STK241.33320185
36RPS6KB21.31150245
37STK101.30990762
38KSR21.30725534
39EPHA31.29437798
40MAP3K121.26520491
41BMX1.23393412
42TYRO31.21356705
43NEK11.20232372
44MAP3K81.14644633
45ERN11.13372906
46TAOK11.10432273
47TESK21.10284898
48MAPK151.09537568
49NUAK11.07713676
50CDK71.07257275
51PTK20.99759888
52CSK0.96303431
53MAP3K70.94682110
54FGFR30.94014418
55MAP2K10.93421874
56NLK0.92007788
57PDPK10.90355930
58MAP3K90.89596946
59TNIK0.88642030
60AURKB0.86971387
61MYLK0.86206053
62LATS10.85239840
63FER0.82768395
64MAP2K60.79456878
65FGR0.78872602
66DMPK0.78479603
67ERBB20.78403852
68PIM20.77064999
69ZAP700.75093133
70STK38L0.72122917
71DYRK1B0.71854297
72PDK10.70333193
73ERBB40.69628857
74MAPK110.69234696
75MAPKAPK30.68435177
76EEF2K0.67260066
77PAK10.67005529
78CDK60.66330295
79PDGFRA0.66010313
80CHEK20.66007862
81MAP3K60.65712998
82SMG10.63358801
83TRIB30.60560696
84PRKAA20.59438189
85TBK10.58535454
86PRKAA10.54420850
87EPHA40.54009608
88IKBKE0.52388967
89PLK10.51945728
90JAK10.51615961
91WNK40.51350139
92CDC42BPA0.50434960
93MAP3K140.50228243
94JAK20.49737045
95RET0.49605451
96ALK0.49497132
97YES10.49142691
98PKN20.48294583
99PRKACG0.48231101
100IRAK10.48049169
101BMPR20.47816575
102ABL20.45109979
103SCYL20.45097445
104MAP3K10.43304158
105FYN0.43023158
106LYN0.42406890
107NEK20.42203224
108CAMK2D0.41158263
109PRKCA0.40925804
110ITK0.40820713
111BTK0.40736335
112LIMK10.40232945
113GSK3A0.40116321
114SYK0.37492845
115GRK10.37315187
116CSF1R0.36791447
117JAK30.36072108
118IRAK40.35507882
119PIM10.35331973
120AKT20.34392077
121EPHB10.33264529
122WEE10.32838997
123PRKD20.31728685
124CDK190.31514671
125RPS6KA10.31327680
126MTOR0.30896920
127LCK0.30859330
128PAK20.29873457
129RAF10.29201475
130CSNK1E0.28256678
131PRKCZ0.28207884
132STK30.27654228
133PRKCD0.26910631
134PRKCQ0.26301241
135PDK20.26097054
136CDK40.25629825
137MAP3K30.24796864
138LRRK20.24625256
139MAPKAPK20.24470123
140BLK0.24269712
141CAMK2G0.22034043
142RPS6KA20.21887204
143MAPK70.21453230
144CSNK1A10.20705595
145TXK0.20512589
146KIT0.20271671
147MELK0.19863742
148CAMK2B0.17909387
149NEK60.17744558
150SRC0.16817540
151CHEK10.15327846

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.87401778
2Mineral absorption_Homo sapiens_hsa049784.41940072
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.12977987
4Sulfur metabolism_Homo sapiens_hsa009203.93610098
5Renin-angiotensin system_Homo sapiens_hsa046143.24376438
6Galactose metabolism_Homo sapiens_hsa000522.88002298
7Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.85710081
8Fructose and mannose metabolism_Homo sapiens_hsa000512.84159639
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.39400474
10Vitamin digestion and absorption_Homo sapiens_hsa049772.37334316
11Folate biosynthesis_Homo sapiens_hsa007902.36240346
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.22452132
13Bile secretion_Homo sapiens_hsa049761.94427820
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.92243722
15Starch and sucrose metabolism_Homo sapiens_hsa005001.74077702
16Caffeine metabolism_Homo sapiens_hsa002321.72889897
17Protein digestion and absorption_Homo sapiens_hsa049741.72689644
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69031709
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61527407
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59824225
21Glutathione metabolism_Homo sapiens_hsa004801.57732810
22Tight junction_Homo sapiens_hsa045301.54363830
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.50848216
24Histidine metabolism_Homo sapiens_hsa003401.50698447
25Carbohydrate digestion and absorption_Homo sapiens_hsa049731.48254875
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45954530
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.43957930
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.31184893
29Linoleic acid metabolism_Homo sapiens_hsa005911.29845672
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.23548995
31Adherens junction_Homo sapiens_hsa045201.20582416
32Arginine and proline metabolism_Homo sapiens_hsa003301.16196739
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15208312
34Thyroid cancer_Homo sapiens_hsa052161.14068748
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10687051
36Asthma_Homo sapiens_hsa053101.07434859
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05254770
38Bladder cancer_Homo sapiens_hsa052191.05224931
39Glycerolipid metabolism_Homo sapiens_hsa005611.04732795
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03388533
41Tryptophan metabolism_Homo sapiens_hsa003801.02460613
42Allograft rejection_Homo sapiens_hsa053300.96508590
43Mismatch repair_Homo sapiens_hsa034300.94130109
44Other glycan degradation_Homo sapiens_hsa005110.92330598
45Autoimmune thyroid disease_Homo sapiens_hsa053200.90155172
46Pentose phosphate pathway_Homo sapiens_hsa000300.89582922
47Arachidonic acid metabolism_Homo sapiens_hsa005900.88774872
48Graft-versus-host disease_Homo sapiens_hsa053320.86676829
49Carbon metabolism_Homo sapiens_hsa012000.86159702
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85805135
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79714716
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78626298
53Staphylococcus aureus infection_Homo sapiens_hsa051500.74347351
54Pancreatic secretion_Homo sapiens_hsa049720.73701573
55Arginine biosynthesis_Homo sapiens_hsa002200.73523779
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.72115935
57Thyroid hormone synthesis_Homo sapiens_hsa049180.70951337
58Biosynthesis of amino acids_Homo sapiens_hsa012300.69208297
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67952525
60PPAR signaling pathway_Homo sapiens_hsa033200.66844299
61Sphingolipid metabolism_Homo sapiens_hsa006000.65112216
62Type I diabetes mellitus_Homo sapiens_hsa049400.61980232
63Hippo signaling pathway_Homo sapiens_hsa043900.60428406
64Nitrogen metabolism_Homo sapiens_hsa009100.59510958
65Fatty acid biosynthesis_Homo sapiens_hsa000610.59331605
66Phenylalanine metabolism_Homo sapiens_hsa003600.58700100
67Sulfur relay system_Homo sapiens_hsa041220.57295923
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.55839885
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.52308303
70DNA replication_Homo sapiens_hsa030300.51154868
71Chemical carcinogenesis_Homo sapiens_hsa052040.50675907
72Fatty acid degradation_Homo sapiens_hsa000710.49958661
73Pyruvate metabolism_Homo sapiens_hsa006200.49575267
74Renin secretion_Homo sapiens_hsa049240.49328030
75Leishmaniasis_Homo sapiens_hsa051400.48529469
76Salmonella infection_Homo sapiens_hsa051320.46046950
77Fatty acid metabolism_Homo sapiens_hsa012120.45752237
78Antigen processing and presentation_Homo sapiens_hsa046120.45408483
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44186227
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43288321
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43132779
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42866845
83Selenocompound metabolism_Homo sapiens_hsa004500.42042171
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41381990
85ABC transporters_Homo sapiens_hsa020100.41196510
86Ether lipid metabolism_Homo sapiens_hsa005650.39540534
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39307738
88African trypanosomiasis_Homo sapiens_hsa051430.38383889
89Peroxisome_Homo sapiens_hsa041460.38374459
90Base excision repair_Homo sapiens_hsa034100.38285572
91Insulin resistance_Homo sapiens_hsa049310.35829306
92Metabolic pathways_Homo sapiens_hsa011000.35027746
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35022577
94Ribosome_Homo sapiens_hsa030100.33703942
95Tyrosine metabolism_Homo sapiens_hsa003500.33233429
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31554888
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.30885725
98Pertussis_Homo sapiens_hsa051330.30629569
99Hepatitis C_Homo sapiens_hsa051600.29876548
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28997313
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28226874
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.27442834
103Viral myocarditis_Homo sapiens_hsa054160.26746736
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.26321731
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.25909854
106Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.25301140
107p53 signaling pathway_Homo sapiens_hsa041150.24023535
108Butanoate metabolism_Homo sapiens_hsa006500.20822748
109Toxoplasmosis_Homo sapiens_hsa051450.19460049
110Hematopoietic cell lineage_Homo sapiens_hsa046400.18923139
111Retinol metabolism_Homo sapiens_hsa008300.18687170
112TGF-beta signaling pathway_Homo sapiens_hsa043500.17667791
113Endometrial cancer_Homo sapiens_hsa052130.17631232
114RNA transport_Homo sapiens_hsa030130.17093404
115Basal cell carcinoma_Homo sapiens_hsa052170.16802230
116Influenza A_Homo sapiens_hsa051640.16595088
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.15620125
118Small cell lung cancer_Homo sapiens_hsa052220.15378713
119VEGF signaling pathway_Homo sapiens_hsa043700.14491239
120Tuberculosis_Homo sapiens_hsa051520.14056191
121mTOR signaling pathway_Homo sapiens_hsa041500.13560969
122Chemokine signaling pathway_Homo sapiens_hsa040620.12714572
123Legionellosis_Homo sapiens_hsa051340.12602678
124Shigellosis_Homo sapiens_hsa051310.12125516
125GnRH signaling pathway_Homo sapiens_hsa049120.12066549
126Choline metabolism in cancer_Homo sapiens_hsa052310.11883518
127Lysine degradation_Homo sapiens_hsa003100.11362835
128N-Glycan biosynthesis_Homo sapiens_hsa005100.11065364
129Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.11049120
130Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.10925855
131Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.10703870
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.09643963
133TNF signaling pathway_Homo sapiens_hsa046680.08417716
134Primary bile acid biosynthesis_Homo sapiens_hsa001200.05735989

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