GPAA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.36541836
2DNA deamination (GO:0045006)8.27535911
3proline metabolic process (GO:0006560)6.37984498
4transcription from mitochondrial promoter (GO:0006390)6.06768960
5telomere maintenance via semi-conservative replication (GO:0032201)5.99552305
6DNA strand elongation involved in DNA replication (GO:0006271)5.67075629
7DNA strand elongation (GO:0022616)5.43922557
8COPI coating of Golgi vesicle (GO:0048205)5.43603249
9Golgi transport vesicle coating (GO:0048200)5.43603249
10replication fork processing (GO:0031297)5.40684523
11maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.96346377
12telomere maintenance via recombination (GO:0000722)4.93432872
13formation of translation preinitiation complex (GO:0001731)4.77359515
14nucleotide-excision repair, DNA gap filling (GO:0006297)4.70314339
15protein maturation by protein folding (GO:0022417)4.62281287
16embryonic process involved in female pregnancy (GO:0060136)4.53455792
17mitotic G1 DNA damage checkpoint (GO:0031571)4.48959577
18somatic hypermutation of immunoglobulin genes (GO:0016446)4.46414209
19somatic diversification of immune receptors via somatic mutation (GO:0002566)4.46414209
20mitochondrial DNA metabolic process (GO:0032042)4.38544836
21negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.33821913
22oxidative demethylation (GO:0070989)4.31564828
23mitotic recombination (GO:0006312)4.31077160
24positive regulation of protein homooligomerization (GO:0032464)4.27394055
25pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.25568987
26negative regulation of cell size (GO:0045792)4.23970949
27viral mRNA export from host cell nucleus (GO:0046784)4.22464844
28mannose metabolic process (GO:0006013)4.20033853
29base-excision repair (GO:0006284)4.19742737
30telomere maintenance via telomere lengthening (GO:0010833)4.11367318
31regulation of translational fidelity (GO:0006450)4.00831670
32DNA replication initiation (GO:0006270)4.00530020
33DNA unwinding involved in DNA replication (GO:0006268)4.00194577
34retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.99110018
35regulation of double-strand break repair via homologous recombination (GO:0010569)3.98713796
36DNA strand renaturation (GO:0000733)3.97526855
37viral transcription (GO:0019083)3.90400196
38mitotic G1/S transition checkpoint (GO:0044819)3.88708732
39* protein retention in ER lumen (GO:0006621)3.83420472
40G1 DNA damage checkpoint (GO:0044783)3.81997604
41negative regulation of RNA splicing (GO:0033119)3.77656679
42UV protection (GO:0009650)3.76436678
43establishment of apical/basal cell polarity (GO:0035089)3.71727679
44barbed-end actin filament capping (GO:0051016)3.71562436
45regulation of protein homooligomerization (GO:0032462)3.69455486
46translational termination (GO:0006415)3.68332820
47mitochondrial RNA metabolic process (GO:0000959)3.67881354
48negative regulation of cell cycle arrest (GO:0071157)3.67832757
49negative regulation of mRNA processing (GO:0050686)3.65837743
50GDP-mannose metabolic process (GO:0019673)3.63536876
51mRNA cleavage (GO:0006379)3.60155228
52* maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.59855113
53pyrimidine nucleotide catabolic process (GO:0006244)3.58042529
54translational elongation (GO:0006414)3.55261852
55glucose catabolic process (GO:0006007)3.53064512
56pentose-phosphate shunt (GO:0006098)3.52102701
57termination of RNA polymerase II transcription (GO:0006369)3.49774292
58semaphorin-plexin signaling pathway (GO:0071526)3.47960539
59base-excision repair, AP site formation (GO:0006285)3.44306431
60ribosomal small subunit assembly (GO:0000028)3.43286102
61regulation of integrin activation (GO:0033623)3.43219013
62regulation of mammary gland epithelial cell proliferation (GO:0033599)3.40952923
63translational initiation (GO:0006413)3.39643142
64basement membrane organization (GO:0071711)3.39083043
65deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.39071899
66pseudouridine synthesis (GO:0001522)3.36476491
67SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.32100781
68NADH metabolic process (GO:0006734)3.30362274
69endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.30169712
70poly(A)+ mRNA export from nucleus (GO:0016973)3.29963960
71apoptotic process involved in morphogenesis (GO:0060561)3.29275182
72amyloid precursor protein catabolic process (GO:0042987)3.28589204
73dosage compensation (GO:0007549)3.27426202
74DNA ligation (GO:0006266)3.26603271
75nuclear envelope reassembly (GO:0031468)3.25425462
76mitotic nuclear envelope reassembly (GO:0007084)3.25425462
77protein localization to endosome (GO:0036010)3.23936548
78protein targeting to ER (GO:0045047)3.22089325
79peptidyl-glutamic acid carboxylation (GO:0017187)3.21828340
80protein carboxylation (GO:0018214)3.21828340
81glucose 6-phosphate metabolic process (GO:0051156)3.21654817
82cotranslational protein targeting to membrane (GO:0006613)3.21532280
83regulation of early endosome to late endosome transport (GO:2000641)3.19002575
84heme biosynthetic process (GO:0006783)3.18131531
85cullin deneddylation (GO:0010388)3.14128810
86establishment of protein localization to mitochondrial membrane (GO:0090151)3.13645864
87nucleobase biosynthetic process (GO:0046112)3.13364113
88pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.12292226
89double-strand break repair via nonhomologous end joining (GO:0006303)3.12271027
90non-recombinational repair (GO:0000726)3.12271027
91establishment of monopolar cell polarity (GO:0061162)3.12239149
92establishment or maintenance of monopolar cell polarity (GO:0061339)3.12239149
93negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.09790402
94protein insertion into membrane (GO:0051205)3.09349365
95regulation of cholesterol biosynthetic process (GO:0045540)3.08974219
96cell-cell junction maintenance (GO:0045217)3.07882891
97DNA integration (GO:0015074)3.07371448
98protein deneddylation (GO:0000338)3.06839270
99nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.05277926
100protein localization to endoplasmic reticulum (GO:0070972)3.04379198
101ribosomal small subunit biogenesis (GO:0042274)3.03753443
102negative regulation of erythrocyte differentiation (GO:0045647)3.03700988
103glutamine family amino acid biosynthetic process (GO:0009084)3.03063880
104maturation of 5.8S rRNA (GO:0000460)3.01207765
105establishment of protein localization to endoplasmic reticulum (GO:0072599)3.00510214
106pentose metabolic process (GO:0019321)2.99338159
107regulation of DNA damage checkpoint (GO:2000001)2.98373578
108negative regulation of JAK-STAT cascade (GO:0046426)2.97410526
109cellular response to zinc ion (GO:0071294)2.97285420
110activation of Rac GTPase activity (GO:0032863)2.96297539
111negative regulation of mRNA metabolic process (GO:1903312)2.95519420
112regulation of double-strand break repair (GO:2000779)2.92011125
113positive regulation of DNA repair (GO:0045739)2.91597778
114NADPH regeneration (GO:0006740)2.91190131
115ribosome biogenesis (GO:0042254)2.90617139
116viral life cycle (GO:0019058)2.90244414
117spliceosomal tri-snRNP complex assembly (GO:0000244)2.89928416
118rRNA processing (GO:0006364)2.88336542
119urea cycle (GO:0000050)2.87827702
120DNA topological change (GO:0006265)2.87326471
121activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.86014573
122positive regulation of developmental pigmentation (GO:0048087)2.85065839
123maturation of SSU-rRNA (GO:0030490)2.84697571
124spliceosomal snRNP assembly (GO:0000387)2.83218640
125virion assembly (GO:0019068)2.82972783
126regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.82126936
127meiotic chromosome segregation (GO:0045132)2.82032573
128regulation of cholesterol metabolic process (GO:0090181)2.81985785
129adhesion of symbiont to host (GO:0044406)2.81961049
130cellular protein complex disassembly (GO:0043624)2.81572345
131kinetochore assembly (GO:0051382)2.80040430
132monosaccharide biosynthetic process (GO:0046364)2.78692933
133amyloid precursor protein metabolic process (GO:0042982)2.76159857
134IMP biosynthetic process (GO:0006188)2.75834554
135mitochondrial DNA replication (GO:0006264)2.75667619
136negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.75050995
137rRNA metabolic process (GO:0016072)2.74853093
138purine nucleobase biosynthetic process (GO:0009113)2.74156244
139positive regulation of nuclease activity (GO:0032075)2.73776759
140folic acid-containing compound biosynthetic process (GO:0009396)2.73690641
141endothelial cell chemotaxis (GO:0035767)2.73584998
142planar cell polarity pathway involved in neural tube closure (GO:0090179)2.72203459
143gluconeogenesis (GO:0006094)2.70753955
144glutathione biosynthetic process (GO:0006750)2.65315461
145maternal placenta development (GO:0001893)2.64873939
146urea metabolic process (GO:0019627)2.64600964
147positive regulation of lipoprotein lipase activity (GO:0051006)2.63312584
148positive regulation of triglyceride lipase activity (GO:0061365)2.63312584
149type B pancreatic cell proliferation (GO:0044342)2.60878108
150regulation of extracellular matrix disassembly (GO:0010715)2.60552450
151pinocytosis (GO:0006907)2.60464204
152pyrimidine nucleoside salvage (GO:0043097)2.59760112
153pyrimidine-containing compound salvage (GO:0008655)2.59760112
154positive regulation of Cdc42 GTPase activity (GO:0043089)2.58639363
155hexose biosynthetic process (GO:0019319)2.58482426
156regulation of apoptotic process involved in morphogenesis (GO:1902337)2.56262423
157virion attachment to host cell (GO:0019062)2.53421546
158adhesion of symbiont to host cell (GO:0044650)2.53421546
159glycosphingolipid catabolic process (GO:0046479)2.52767024
160adherens junction assembly (GO:0034333)2.51381234
161nucleoside diphosphate biosynthetic process (GO:0009133)2.50579285
162nucleobase-containing small molecule interconversion (GO:0015949)2.50045179
163epithelial cell-cell adhesion (GO:0090136)2.49859029
164stress fiber assembly (GO:0043149)2.48806588
165nitrogen cycle metabolic process (GO:0071941)2.47931822
166L-phenylalanine metabolic process (GO:0006558)2.47070809
167erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.47070809
168focal adhesion assembly (GO:0048041)2.46959709
169cell-substrate adherens junction assembly (GO:0007045)2.46959709
170hyaluronan catabolic process (GO:0030214)2.45777760
171regulation of glucose import in response to insulin stimulus (GO:2001273)2.45497589
172glial cell migration (GO:0008347)2.44724761
173viral protein processing (GO:0019082)2.42865388
1744-hydroxyproline metabolic process (GO:0019471)2.42364387
175embryo implantation (GO:0007566)2.41163684
176folic acid metabolic process (GO:0046655)2.41093971
177tricarboxylic acid metabolic process (GO:0072350)2.39182496
178endoplasmic reticulum unfolded protein response (GO:0030968)2.39142498
179peptidyl-proline hydroxylation (GO:0019511)2.38778687
180modulation by virus of host morphology or physiology (GO:0019048)2.38058535
181positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.36845367
182regulation of nuclease activity (GO:0032069)2.36671212
183nonribosomal peptide biosynthetic process (GO:0019184)2.36629832
184regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.34006735
185positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.33138206
186cell-substrate junction assembly (GO:0007044)2.32108793
187retrograde transport, endosome to Golgi (GO:0042147)2.31949393
188prostaglandin biosynthetic process (GO:0001516)2.31699422
189prostanoid biosynthetic process (GO:0046457)2.31699422
190regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.29124024
191skin morphogenesis (GO:0043589)2.28062787

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.59259756
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.97851736
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.74117842
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.51413258
5* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83593383
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.80144201
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.67631236
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60222800
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.53813749
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.50627491
11VDR_21846776_ChIP-Seq_THP-1_Human2.46748470
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37471718
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.34063593
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.26753137
15ZNF263_19887448_ChIP-Seq_K562_Human2.23039213
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17192276
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05470366
18MYC_22102868_ChIP-Seq_BL_Human2.02104487
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01555750
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.00886498
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.00520561
22E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95253537
23THAP11_20581084_ChIP-Seq_MESCs_Mouse1.93081468
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92615020
25P68_20966046_ChIP-Seq_HELA_Human1.90380955
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.89435022
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88936062
28XRN2_22483619_ChIP-Seq_HELA_Human1.85315611
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.79523046
30* GABP_19822575_ChIP-Seq_HepG2_Human1.77952940
31* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.75920625
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75569548
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.74940014
34* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73480033
35DCP1A_22483619_ChIP-Seq_HELA_Human1.73442458
36KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.73006803
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.72748008
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71131203
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68221882
40SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.66831334
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.66762017
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.64100211
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62769302
44CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.62407416
45KDM2B_26808549_Chip-Seq_DND41_Human1.61284797
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.61126178
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58222557
48CTCF_27219007_Chip-Seq_ERYTHROID_Human1.57246090
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.55051643
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.55012198
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.54135827
52VDR_23849224_ChIP-Seq_CD4+_Human1.52811073
53* LXR_22292898_ChIP-Seq_THP-1_Human1.52501910
54ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.52238252
55ELF1_20517297_ChIP-Seq_JURKAT_Human1.51911286
56* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51073013
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.49833869
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49115813
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48873536
60* SMC4_20622854_ChIP-Seq_HELA_Human1.48254951
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47473653
62* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45331345
63SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.44266051
64TTF2_22483619_ChIP-Seq_HELA_Human1.43572904
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43512576
66TCF7_22412390_ChIP-Seq_EML_Mouse1.43008153
67EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42051400
68KDM2B_26808549_Chip-Seq_K562_Human1.41738689
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37053794
70PU.1_20513432_ChIP-Seq_Bcells_Mouse1.35936635
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34888428
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34733612
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32778136
74FOXP3_21729870_ChIP-Seq_TREG_Human1.32364326
75CREB1_26743006_Chip-Seq_LNCaP_Human1.31017260
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29981349
77KDM5A_27292631_Chip-Seq_BREAST_Human1.29728400
78TP53_22127205_ChIP-Seq_IMR90_Human1.28665389
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28385921
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27567673
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27562355
82* ATF3_27146783_Chip-Seq_COLON_Human1.27335461
83CTCF_27219007_Chip-Seq_Bcells_Human1.26501014
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26479363
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.25843841
86* SRF_21415370_ChIP-Seq_HL-1_Mouse1.25843384
87SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.25560260
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24557003
89* E2F1_21310950_ChIP-Seq_MCF-7_Human1.24157727
90MAF_26560356_Chip-Seq_TH2_Human1.23577541
91* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23156369
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.22481798
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22235917
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.22158683
95* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22016117
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21569277
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21531525
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21428318
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21247178
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20928031
101RARB_24833708_ChIP-Seq_LIVER_Mouse1.20743917
102CTCF_18555785_ChIP-Seq_MESCs_Mouse1.20363123
103* CTCF_26484167_Chip-Seq_Bcells_Mouse1.20287976
104KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20280272
105KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20280272
106KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20280272
107PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19876954
108PPARA_22158963_ChIP-Seq_LIVER_Mouse1.19584591
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19338459
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19133447
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18501772
112* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.17442873
113NANOG_21062744_ChIP-ChIP_HESCs_Human1.16674476
114RXR_22158963_ChIP-Seq_LIVER_Mouse1.16215349
115RARA_24833708_ChIP-Seq_LIVER_Mouse1.15699552
116SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15570925
117HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15253372
118SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13390572
119MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12753896
120* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12722695
121* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12167690
122POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11981496
123CTCF_21964334_Chip-Seq_Bcells_Human1.11934629
124CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11697319
125TFEB_21752829_ChIP-Seq_HELA_Human1.11680365
126SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11267629
127PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10767971
128* E2F1_20622854_ChIP-Seq_HELA_Human1.10741357
129CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10711173
130MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10703974
131ELK3_25401928_ChIP-Seq_HUVEC_Human1.10694229
132KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10557530
133P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10206294
134* PHF8_20622854_ChIP-Seq_HELA_Human1.09998838
135NCOR1_26117541_ChIP-Seq_K562_Human1.09885918
136VDR_24763502_ChIP-Seq_THP-1_Human1.09847951
137TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09598152
138* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08515190
139CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08365436
140AR_21909140_ChIP-Seq_LNCAP_Human1.07149327
141MAF_26560356_Chip-Seq_TH1_Human1.06308326
142HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05745001
143SA1_27219007_Chip-Seq_Bcells_Human1.05249290
144CIITA_25753668_ChIP-Seq_RAJI_Human1.04433208
145ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04023945
146NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03943502
147ETS1_21867929_ChIP-Seq_TH2_Mouse1.03611809
148HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02397614
149* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02166349
150* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02064760
151RACK7_27058665_Chip-Seq_MCF-7_Human1.01123395
152NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00837376
153TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99273390
154SPI1_23547873_ChIP-Seq_NB4_Human0.98999820
155NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97158590
156SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97086272
157* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96846671
158* BCL6_27268052_Chip-Seq_Bcells_Human0.96797629
159ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96242948
160FOXP1_21924763_ChIP-Seq_HESCs_Human0.94786273
161SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94425151
162KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93890380
163HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93336403
164* YY1_22570637_ChIP-Seq_MALME-3M_Human0.92436586
165* BCOR_27268052_Chip-Seq_Bcells_Human0.92194804

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.37623393
2MP0003705_abnormal_hypodermis_morpholog4.46396585
3MP0009278_abnormal_bone_marrow3.87588226
4MP0005451_abnormal_body_composition3.48431974
5MP0010094_abnormal_chromosome_stability3.37028971
6MP0008438_abnormal_cutaneous_collagen3.34957457
7MP0004957_abnormal_blastocyst_morpholog3.07141630
8MP0010030_abnormal_orbit_morphology3.02792349
9MP0005171_absent_coat_pigmentation2.95912699
10MP0003693_abnormal_embryo_hatching2.95036743
11MP0001545_abnormal_hematopoietic_system2.92903576
12MP0005397_hematopoietic_system_phenotyp2.92903576
13MP0004858_abnormal_nervous_system2.69596797
14MP0003111_abnormal_nucleus_morphology2.69163037
15MP0008260_abnormal_autophagy2.63335924
16MP0008058_abnormal_DNA_repair2.51750937
17MP0004233_abnormal_muscle_weight2.49364424
18MP0000490_abnormal_crypts_of2.47544932
19MP0000751_myopathy2.45047195
20MP0003077_abnormal_cell_cycle2.44742778
21MP0003191_abnormal_cellular_cholesterol2.36802597
22MP0005257_abnormal_intraocular_pressure2.28566776
23MP0001849_ear_inflammation2.27878054
24MP0005174_abnormal_tail_pigmentation2.18956040
25MP0002396_abnormal_hematopoietic_system2.17454443
26MP0008932_abnormal_embryonic_tissue1.98515141
27MP0010352_gastrointestinal_tract_polyps1.95047336
28MP0002877_abnormal_melanocyte_morpholog1.94782985
29MP0003566_abnormal_cell_adhesion1.94154828
30MP0003786_premature_aging1.90674905
31MP0003329_amyloid_beta_deposits1.81078645
32MP0003656_abnormal_erythrocyte_physiolo1.81008578
33MP0005075_abnormal_melanosome_morpholog1.80588501
34MP0010234_abnormal_vibrissa_follicle1.79289778
35MP0000003_abnormal_adipose_tissue1.79032584
36MP0005058_abnormal_lysosome_morphology1.78766284
37MP0004133_heterotaxia1.77185051
38MP0003172_abnormal_lysosome_physiology1.71952569
39MP0003279_aneurysm1.68252636
40MP0000678_abnormal_parathyroid_gland1.64610552
41MP0000685_abnormal_immune_system1.53314424
42MP0009333_abnormal_splenocyte_physiolog1.52168466
43MP0001958_emphysema1.52025147
44MP0001697_abnormal_embryo_size1.49238958
45MP0005360_urolithiasis1.48530130
46MP0003806_abnormal_nucleotide_metabolis1.46521586
47MP0000858_altered_metastatic_potential1.45631548
48MP0000750_abnormal_muscle_regeneration1.45208734
49MP0005083_abnormal_biliary_tract1.44806844
50MP0001730_embryonic_growth_arrest1.44799377
51MP0000350_abnormal_cell_proliferation1.44398666
52MP0008995_early_reproductive_senescence1.44044306
53MP0002019_abnormal_tumor_incidence1.41754364
54MP0004185_abnormal_adipocyte_glucose1.41072021
55MP0002086_abnormal_extraembryonic_tissu1.39084754
56MP0005375_adipose_tissue_phenotype1.38119358
57MP0000747_muscle_weakness1.36715076
58MP0002132_abnormal_respiratory_system1.34895132
59MP0005330_cardiomyopathy1.32963397
60MP0004510_myositis1.32402647
61MP0008007_abnormal_cellular_replicative1.28460342
62MP0005666_abnormal_adipose_tissue1.27260764
63MP0003567_abnormal_fetal_cardiomyocyte1.26837210
64MP0003075_altered_response_to1.26777476
65MP0006054_spinal_hemorrhage1.26434998
66MP0003119_abnormal_digestive_system1.26338888
67MP0004272_abnormal_basement_membrane1.25417612
68MP0004197_abnormal_fetal_growth/weight/1.24838949
69MP0002080_prenatal_lethality1.24670612
70MP0002085_abnormal_embryonic_tissue1.23458640
71MP0005076_abnormal_cell_differentiation1.23450896
72MP0001661_extended_life_span1.23143644
73MP0000013_abnormal_adipose_tissue1.22264438
74MP0001293_anophthalmia1.21606362
75MP0002084_abnormal_developmental_patter1.21048743
76MP0003283_abnormal_digestive_organ1.20698559
77MP0003890_abnormal_embryonic-extraembry1.19459921
78MP0000604_amyloidosis1.19029515
79MP0001672_abnormal_embryogenesis/_devel1.18959108
80MP0005380_embryogenesis_phenotype1.18959108
81MP0000313_abnormal_cell_death1.17140944
82MP0002139_abnormal_hepatobiliary_system1.16963766
83MP0000689_abnormal_spleen_morphology1.15894450
84MP0005409_darkened_coat_color1.15683316
85MP0002249_abnormal_larynx_morphology1.15309208
86MP0002653_abnormal_ependyma_morphology1.13081840
87MP0000015_abnormal_ear_pigmentation1.12988256
88MP0002405_respiratory_system_inflammati1.11075933
89MP0000681_abnormal_thyroid_gland1.08573231
90MP0003436_decreased_susceptibility_to1.08373464
91MP0003453_abnormal_keratinocyte_physiol1.07925638
92MP0000465_gastrointestinal_hemorrhage1.07248984
93MP0000371_diluted_coat_color1.06471593
94MP0009384_cardiac_valve_regurgitation1.05676013
95MP0003091_abnormal_cell_migration1.05605488
96MP0000470_abnormal_stomach_morphology1.04993277
97MP0003879_abnormal_hair_cell1.04972309
98MP0002111_abnormal_tail_morphology1.03135347
99MP0002009_preneoplasia1.02181853
100MP0002269_muscular_atrophy1.02031486
101MP0005670_abnormal_white_adipose1.01471816
102MP0004381_abnormal_hair_follicle0.99178589
103MP0002722_abnormal_immune_system0.98779023
104MP0003984_embryonic_growth_retardation0.98442625
105MP0001243_abnormal_dermal_layer0.97537764
106MP0003763_abnormal_thymus_physiology0.97126575
107MP0002282_abnormal_trachea_morphology0.96523314
108MP0001348_abnormal_lacrimal_gland0.95824093
109MP0000343_altered_response_to0.95756976
110MP0008877_abnormal_DNA_methylation0.95730737
111MP0002398_abnormal_bone_marrow0.94681218
112MP0002088_abnormal_embryonic_growth/wei0.93465625
113MP0003634_abnormal_glial_cell0.91179977
114MP0005501_abnormal_skin_physiology0.90468508
115MP0003828_pulmonary_edema0.90086407
116MP0004147_increased_porphyrin_level0.89911359
117MP0009931_abnormal_skin_appearance0.89491829
118MP0002075_abnormal_coat/hair_pigmentati0.89112871
119MP0001542_abnormal_bone_strength0.88487960
120MP0005508_abnormal_skeleton_morphology0.87978335
121MP0000358_abnormal_cell_content/0.87740970
122MP0000467_abnormal_esophagus_morphology0.87673375
123MP0004947_skin_inflammation0.87514125
124MP0000477_abnormal_intestine_morphology0.87355050
125MP0001216_abnormal_epidermal_layer0.87333017
126MP0005584_abnormal_enzyme/coenzyme_acti0.87262702
127MP0000703_abnormal_thymus_morphology0.87242842
128MP0000759_abnormal_skeletal_muscle0.86890771
129MP0001873_stomach_inflammation0.85364122
130MP0006036_abnormal_mitochondrial_physio0.84763189
131MP0002932_abnormal_joint_morphology0.84266989
132MP0002166_altered_tumor_susceptibility0.83440531
133MP0005165_increased_susceptibility_to0.83235654
134MP0005023_abnormal_wound_healing0.82142446
135MP0003123_paternal_imprinting0.81578989
136MP0005365_abnormal_bile_salt0.80845232
137MP0000733_abnormal_muscle_development0.80708667
138MP0005266_abnormal_metabolism0.80421130
139MP0005503_abnormal_tendon_morphology0.80350700
140MP0010771_integument_phenotype0.78662045
141MP0004808_abnormal_hematopoietic_stem0.78570630
142MP0009643_abnormal_urine_homeostasis0.78305279
143MP0002429_abnormal_blood_cell0.77269436
144MP0000462_abnormal_digestive_system0.76449087
145MP0003718_maternal_effect0.74380531
146MP0003303_peritoneal_inflammation0.73736426
147MP0005464_abnormal_platelet_physiology0.73248400
148MP0005220_abnormal_exocrine_pancreas0.72582310
149MP0003221_abnormal_cardiomyocyte_apopto0.72174140
150MP0005390_skeleton_phenotype0.72169294
151MP0000579_abnormal_nail_morphology0.70948253
152MP0002089_abnormal_postnatal_growth/wei0.70479321
153MP0006072_abnormal_retinal_apoptosis0.70033278
154MP0010155_abnormal_intestine_physiology0.70028668
155MP0008874_decreased_physiological_sensi0.69705997
156MP0001186_pigmentation_phenotype0.69567413
157MP0005621_abnormal_cell_physiology0.69263589
158MP0002970_abnormal_white_adipose0.68983880
159MP0002796_impaired_skin_barrier0.68883603
160MP0009840_abnormal_foam_cell0.68531540
161MP0003866_abnormal_defecation0.68285897
162MP0001881_abnormal_mammary_gland0.68017508
163MP0002060_abnormal_skin_morphology0.67550969
164MP0004264_abnormal_extraembryonic_tissu0.67409800
165MP0000537_abnormal_urethra_morphology0.67354492
166MP0002896_abnormal_bone_mineralization0.66616486
167MP0010307_abnormal_tumor_latency0.65429215
168MP0001764_abnormal_homeostasis0.64685286
169MP0001533_abnormal_skeleton_physiology0.64206820
170MP0002254_reproductive_system_inflammat0.62357442
171MP0005623_abnormal_meninges_morphology0.62242177
172MP0000538_abnormal_urinary_bladder0.61081773
173MP0004087_abnormal_muscle_fiber0.60368809

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)5.14550746
2Poikiloderma (HP:0001029)4.56200193
3Tongue fasciculations (HP:0001308)4.23699745
4Facial hemangioma (HP:0000329)4.11443917
5Abnormality of cells of the erythroid lineage (HP:0012130)4.03429704
6Abnormal number of erythroid precursors (HP:0012131)4.02643807
7Vertebral compression fractures (HP:0002953)3.99261378
8Muscle fibrillation (HP:0010546)3.86230823
9Rib fusion (HP:0000902)3.83376054
10Premature rupture of membranes (HP:0001788)3.72327204
11Concave nail (HP:0001598)3.59924921
12Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.59790353
13Selective tooth agenesis (HP:0001592)3.59661058
14Annular pancreas (HP:0001734)3.49615017
15Protrusio acetabuli (HP:0003179)3.33629777
16Rectovaginal fistula (HP:0000143)3.32702500
17Rectal fistula (HP:0100590)3.32702500
18Achilles tendon contracture (HP:0001771)3.28636108
19Upper limb amyotrophy (HP:0009129)3.27169261
20Distal upper limb amyotrophy (HP:0007149)3.27169261
21J-shaped sella turcica (HP:0002680)3.24189783
22Premature graying of hair (HP:0002216)3.20861636
23Distal lower limb muscle weakness (HP:0009053)3.10786681
24Diaphragmatic weakness (HP:0009113)3.08244919
25Vaginal fistula (HP:0004320)3.07530704
26Basal cell carcinoma (HP:0002671)3.07385250
27Urinary glycosaminoglycan excretion (HP:0003541)3.06307250
28Mucopolysacchariduria (HP:0008155)3.06307250
29Cervical subluxation (HP:0003308)3.05794444
30Abnormality of the Achilles tendon (HP:0005109)3.05781767
31Increased IgM level (HP:0003496)2.98224511
32Exertional dyspnea (HP:0002875)2.97677722
33Thin bony cortex (HP:0002753)2.96659579
34Dysostosis multiplex (HP:0000943)2.95071507
35Abnormality of liposaccharide metabolism (HP:0010968)2.94857395
36Abnormality of glycosphingolipid metabolism (HP:0004343)2.94857395
37Abnormality of glycolipid metabolism (HP:0010969)2.94857395
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.88368753
39Ulnar bowing (HP:0003031)2.88086629
40Intestinal fistula (HP:0100819)2.87072261
41Patellar aplasia (HP:0006443)2.86386670
42Stridor (HP:0010307)2.85913613
43Abnormal hemoglobin (HP:0011902)2.81575849
44Hyperacusis (HP:0010780)2.76336836
45Short nail (HP:0001799)2.75999621
46Joint stiffness (HP:0001387)2.75447928
47Testicular atrophy (HP:0000029)2.75408991
48Abnormal gallbladder physiology (HP:0012438)2.74305850
49Cholecystitis (HP:0001082)2.74305850
50Alopecia of scalp (HP:0002293)2.73998508
51Distal lower limb amyotrophy (HP:0008944)2.72588880
52Reticulocytopenia (HP:0001896)2.72047334
53Vertebral hypoplasia (HP:0008417)2.72041445
54Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.72041445
55Albinism (HP:0001022)2.71580947
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.71056509
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.71056509
58Abnormality of polysaccharide metabolism (HP:0011012)2.71056509
59Squamous cell carcinoma (HP:0002860)2.68707143
60Hemorrhage of the eye (HP:0011885)2.68223371
61Absent thumb (HP:0009777)2.67884980
62Hand muscle atrophy (HP:0009130)2.67434635
63Increased cerebral lipofuscin (HP:0011813)2.66769259
64Hypokinesia (HP:0002375)2.66176383
65Orthostatic hypotension (HP:0001278)2.62044839
66Aplasia/Hypoplasia of the patella (HP:0006498)2.61017308
67Congenital hip dislocation (HP:0001374)2.57302600
68Turricephaly (HP:0000262)2.57143210
69Increased neuronal autofluorescent lipopigment (HP:0002074)2.53232774
70Type I transferrin isoform profile (HP:0003642)2.52841381
71Increased connective tissue (HP:0009025)2.52248101
72Aplasia/hypoplasia of the humerus (HP:0006507)2.52051537
73Cerebral aneurysm (HP:0004944)2.48309108
74Abnormality of male internal genitalia (HP:0000022)2.44014921
75Premature skin wrinkling (HP:0100678)2.42360776
76Axonal loss (HP:0003447)2.40999424
77Hypochromic microcytic anemia (HP:0004840)2.40714730
78Short humerus (HP:0005792)2.40533158
79Myopathic facies (HP:0002058)2.39497157
80Broad alveolar ridges (HP:0000187)2.38442446
81Pancreatic islet-cell hyperplasia (HP:0004510)2.37871547
82Nuclear cataract (HP:0100018)2.37670821
83Polycythemia (HP:0001901)2.37539217
84Absent radius (HP:0003974)2.33817834
85Loss of speech (HP:0002371)2.32102425
86Fragile skin (HP:0001030)2.31697347
87Prolonged neonatal jaundice (HP:0006579)2.29427961
88Spinal rigidity (HP:0003306)2.24945967
89Bulbar palsy (HP:0001283)2.22883304
90Oral leukoplakia (HP:0002745)2.22086575
91Ragged-red muscle fibers (HP:0003200)2.21122144
92Abnormality of the distal phalanges of the toes (HP:0010182)2.20635791
93Generalized amyotrophy (HP:0003700)2.19431678
94Aplasia involving forearm bones (HP:0009822)2.16683234
95Absent forearm bone (HP:0003953)2.16683234
96Short chin (HP:0000331)2.16397165
97Mildly elevated creatine phosphokinase (HP:0008180)2.16250966
98Large for gestational age (HP:0001520)2.16141455
99Broad distal phalanx of finger (HP:0009836)2.16137880
100Abnormality of lateral ventricle (HP:0030047)2.15983972
101Rough bone trabeculation (HP:0100670)2.15668111
102Anteriorly placed anus (HP:0001545)2.13096682
103Broad face (HP:0000283)2.11404973
104Opisthotonus (HP:0002179)2.11163441
105Biconcave vertebral bodies (HP:0004586)2.10348690
106Bifid uvula (HP:0000193)2.09599319
107Abnormality of the thoracic spine (HP:0100711)2.09343445
108Acute lymphatic leukemia (HP:0006721)2.09166137
109Dysautonomia (HP:0002459)2.08952404
110Hypochromic anemia (HP:0001931)2.08444473
111Mitral regurgitation (HP:0001653)2.07997361
112Increased variability in muscle fiber diameter (HP:0003557)2.07899850
113Centrally nucleated skeletal muscle fibers (HP:0003687)2.07879861
114Abnormal number of incisors (HP:0011064)2.07069425
115Blue sclerae (HP:0000592)2.06537958
116Elbow flexion contracture (HP:0002987)2.06368964
117Intestinal atresia (HP:0011100)2.04872746
118Birth length less than 3rd percentile (HP:0003561)2.04670934
119Decreased activity of mitochondrial respiratory chain (HP:0008972)2.03901754
120Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.03901754
121Hypoplasia of the radius (HP:0002984)2.03489202
122Aplastic anemia (HP:0001915)2.02117599
123Breast hypoplasia (HP:0003187)2.01453096
124Flattened epiphyses (HP:0003071)2.00544493
125Degeneration of anterior horn cells (HP:0002398)2.00404908
126Abnormality of the anterior horn cell (HP:0006802)2.00404908
127Systemic lupus erythematosus (HP:0002725)2.00120903
128Thrombocytosis (HP:0001894)1.98989031
129Redundant skin (HP:0001582)1.98884710
130Abnormality of T cell physiology (HP:0011840)1.98268293
131Abnormality of endocrine pancreas physiology (HP:0012093)1.97725297
132Abnormality of the pancreatic islet cells (HP:0006476)1.97725297
133Macrocytic anemia (HP:0001972)1.96941041
134Growth hormone excess (HP:0000845)1.96826614
135Capillary hemangiomas (HP:0005306)1.96173486
136Thoracic kyphosis (HP:0002942)1.95213225
137Reticulocytosis (HP:0001923)1.94871411
138Back pain (HP:0003418)1.93924073
139Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93747793
140Microretrognathia (HP:0000308)1.92847963
141Gastrointestinal dysmotility (HP:0002579)1.91345214
142Muscle fiber atrophy (HP:0100295)1.90693010
143Hyperparathyroidism (HP:0000843)1.89659532
144Atrophic scars (HP:0001075)1.89575474
145Microcytic anemia (HP:0001935)1.89393537
146Difficulty climbing stairs (HP:0003551)1.88736199
147Bowing of the arm (HP:0006488)1.87384147
148Bowed forearm bones (HP:0003956)1.87384147
149Ankle contracture (HP:0006466)1.87341572
150Hypotrichosis (HP:0001006)1.87165648
151Insomnia (HP:0100785)1.86855397
152Xanthomatosis (HP:0000991)1.86668309
153Deep venous thrombosis (HP:0002625)1.86323112
154Abnormality of the heme biosynthetic pathway (HP:0010472)1.86110801
155Abnormality of skeletal muscle fiber size (HP:0012084)1.85412581
156Abnormality of the aortic arch (HP:0012303)1.84573400
157Reduced antithrombin III activity (HP:0001976)1.84424474
158Agnosia (HP:0010524)1.83938865
159Progressive muscle weakness (HP:0003323)1.83863051
160Alacrima (HP:0000522)1.83619206
161Hypertriglyceridemia (HP:0002155)1.83501697
162Hyperthyroidism (HP:0000836)1.82800329
163Progressive neurologic deterioration (HP:0002344)1.81827594
164Cholelithiasis (HP:0001081)1.80925018
165Short 5th finger (HP:0009237)1.80323763
166Shallow orbits (HP:0000586)1.79638286
167Easy fatigability (HP:0003388)1.79125317
168Supranuclear gaze palsy (HP:0000605)1.78700934
169Obstructive sleep apnea (HP:0002870)1.78611937
170Asymmetric septal hypertrophy (HP:0001670)1.77589050
171Wormian bones (HP:0002645)1.77520139
172Hypertensive crisis (HP:0100735)1.75610821
173Atelectasis (HP:0100750)1.75580270
174Long palpebral fissure (HP:0000637)1.75334787
175Vacuolated lymphocytes (HP:0001922)1.74597806
176Abdominal distention (HP:0003270)1.72220021
177Long toe (HP:0010511)1.71459460
178Purpura (HP:0000979)1.68707946
179Bladder diverticulum (HP:0000015)1.67308963
180Trismus (HP:0000211)1.67005476
181Interstitial pulmonary disease (HP:0006530)1.65265047
182Flat acetabular roof (HP:0003180)1.65192184
183Cerebral inclusion bodies (HP:0100314)1.64649936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.36847157
2PIM23.95017687
3MAP3K113.49484820
4MAPK153.43596447
5MAP3K63.36893349
6SIK13.28512126
7DDR23.17866650
8EPHA23.11591831
9IRAK33.06205100
10TESK13.03211513
11SMG12.59892529
12MATK2.57194411
13DAPK12.56518978
14CDK72.33208178
15WEE12.21463348
16MST1R1.95930950
17PINK11.92515874
18UHMK11.88907615
19ACVR1B1.87827676
20BUB11.83051602
21STK161.82803323
22PRPF4B1.82799585
23FGR1.79655618
24BCKDK1.76437132
25NME21.73299336
26LMTK21.55191580
27CDC71.52995531
28PRKD21.52930249
29CSK1.52906143
30RIPK11.51940060
31DYRK1B1.51356907
32PIM11.47694748
33YES11.47181938
34RPS6KC11.45845798
35RPS6KL11.45845798
36TYRO31.45128050
37TTN1.44942875
38DYRK31.43513325
39LIMK11.42459619
40RPS6KA61.31033991
41VRK21.29757792
42PRKD31.27650739
43BMX1.23897678
44MAPKAPK31.23146178
45EIF2AK31.22828892
46PDGFRA1.20814394
47RPS6KB21.19963758
48TESK21.18464994
49TRPM71.16538628
50NEK21.15877741
51PLK11.15442660
52TAOK11.14040285
53PTK21.12471631
54TBK11.11401555
55MAPK111.10540428
56CHEK21.08971108
57EPHB11.08946865
58PTK61.07946018
59ATR1.06618286
60TRIB31.05014383
61MAP3K101.04862862
62KDR1.04845560
63CDK61.03773987
64ABL21.02527889
65MAP4K11.00650989
66BTK0.91458260
67BRSK20.91182940
68IRAK20.88675986
69RPS6KA20.87599456
70CDK80.87340237
71AURKA0.86884737
72TAOK20.86557324
73EPHB20.85487751
74MAP3K10.85129331
75MAP2K30.83129967
76BRAF0.82859071
77MET0.82016939
78RAF10.81777597
79NEK10.81309087
80MUSK0.81130316
81BRSK10.80830837
82PAK40.79059861
83PDPK10.78766733
84BLK0.77757761
85AURKB0.77576226
86STK100.76876263
87EIF2AK10.75421115
88FLT30.73856584
89MARK20.73689648
90NTRK10.71213079
91FGFR40.70653550
92CDK40.69588707
93LYN0.69225052
94VRK10.67426450
95PAK10.64437500
96LRRK20.61729671
97RPS6KA10.59473313
98CSNK2A10.59249266
99MAPK40.58489828
100DAPK30.57965166
101ARAF0.57354841
102MAP2K20.57215582
103ERN10.56840498
104TLK10.54834966
105EEF2K0.54185780
106CAMK2G0.53344255
107MAP2K60.52682673
108KIT0.52482753
109TNK20.52395707
110SCYL20.51698655
111MAP3K80.51088844
112GSK3A0.50966389
113CDK20.50838514
114SIK30.49370230
115MAP3K130.49168211
116ERBB30.48891068
117MAPK120.47066108
118TGFBR10.46870391
119CSNK2A20.46205135
120MTOR0.45335062
121CDC42BPA0.45226590
122MAPKAPK20.44583465
123PKN20.43730013
124MOS0.43401533
125PRKG20.42216506
126MYLK0.41283205
127AKT20.41280003
128GRK60.41202295
129CDK190.40901055
130PRKCI0.40777554
131IRAK40.40491165
132HIPK20.40479923
133CDK11A0.40472735
134STK380.40385236
135MAP3K30.39791310
136CHEK10.39314310
137ILK0.39049056
138DYRK20.38984245
139PHKG20.38407457
140PHKG10.38407457
141CDK150.37267894
142CDK140.36824589
143TYK20.36742341
144MAPK30.36554606
145ZAP700.36430674
146SIK20.36307253
147PASK0.36133659
148PRKD10.35874998
149CDK180.31483616
150TTK0.31085298
151KSR20.30834645
152CAMKK10.30068737
153CAMK2B0.29890487
154PRKAA10.29715407

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.77911257
2Mismatch repair_Homo sapiens_hsa034305.11994476
3Base excision repair_Homo sapiens_hsa034104.54817357
4Ribosome_Homo sapiens_hsa030103.36021679
5Nucleotide excision repair_Homo sapiens_hsa034202.77618417
6Spliceosome_Homo sapiens_hsa030402.65061648
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.57994215
8Homologous recombination_Homo sapiens_hsa034402.52723989
9Proteasome_Homo sapiens_hsa030502.47829968
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.31329925
11Fatty acid biosynthesis_Homo sapiens_hsa000612.27564992
12RNA transport_Homo sapiens_hsa030132.00595776
13Cell cycle_Homo sapiens_hsa041101.90186089
14Sulfur relay system_Homo sapiens_hsa041221.88935559
15Folate biosynthesis_Homo sapiens_hsa007901.88052413
16One carbon pool by folate_Homo sapiens_hsa006701.81014742
17Vibrio cholerae infection_Homo sapiens_hsa051101.73360165
18Pyrimidine metabolism_Homo sapiens_hsa002401.70898749
19Biosynthesis of amino acids_Homo sapiens_hsa012301.70405988
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.68890735
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.66763771
22RNA polymerase_Homo sapiens_hsa030201.60726965
23Fanconi anemia pathway_Homo sapiens_hsa034601.60572069
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52229348
25Phenylalanine metabolism_Homo sapiens_hsa003601.51478220
26Prion diseases_Homo sapiens_hsa050201.50478491
27Arginine and proline metabolism_Homo sapiens_hsa003301.47955533
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.47638043
29p53 signaling pathway_Homo sapiens_hsa041151.42616221
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.38666699
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31781951
32Pentose phosphate pathway_Homo sapiens_hsa000301.26282779
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21012403
34mRNA surveillance pathway_Homo sapiens_hsa030151.14183039
35Galactose metabolism_Homo sapiens_hsa000521.10994223
36Notch signaling pathway_Homo sapiens_hsa043301.10541667
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07865373
38Tyrosine metabolism_Homo sapiens_hsa003501.04260149
39N-Glycan biosynthesis_Homo sapiens_hsa005101.04145021
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99941108
41Glycosaminoglycan degradation_Homo sapiens_hsa005310.98572992
42Shigellosis_Homo sapiens_hsa051310.96781974
43Glutathione metabolism_Homo sapiens_hsa004800.95058918
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.94223059
45Fructose and mannose metabolism_Homo sapiens_hsa000510.91584419
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89744519
47Sphingolipid metabolism_Homo sapiens_hsa006000.87559474
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85673174
49Sulfur metabolism_Homo sapiens_hsa009200.84227713
50AMPK signaling pathway_Homo sapiens_hsa041520.81604619
51RNA degradation_Homo sapiens_hsa030180.81264909
52Endocytosis_Homo sapiens_hsa041440.81085488
53Bladder cancer_Homo sapiens_hsa052190.78806745
54Insulin signaling pathway_Homo sapiens_hsa049100.78266054
55Synaptic vesicle cycle_Homo sapiens_hsa047210.78014995
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77405374
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76114753
58Vitamin B6 metabolism_Homo sapiens_hsa007500.75895259
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74369586
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73293037
61Basal transcription factors_Homo sapiens_hsa030220.72692233
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72369007
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72221051
64Protein export_Homo sapiens_hsa030600.71933136
65Non-small cell lung cancer_Homo sapiens_hsa052230.71413059
66Legionellosis_Homo sapiens_hsa051340.70903204
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70207737
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69988834
69Circadian rhythm_Homo sapiens_hsa047100.69324787
70Non-homologous end-joining_Homo sapiens_hsa034500.69163177
71Other glycan degradation_Homo sapiens_hsa005110.68305985
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.68168442
73Pyruvate metabolism_Homo sapiens_hsa006200.68026558
74Hedgehog signaling pathway_Homo sapiens_hsa043400.67959099
75Parkinsons disease_Homo sapiens_hsa050120.67420130
76Epstein-Barr virus infection_Homo sapiens_hsa051690.67250361
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.66703666
78Hepatitis C_Homo sapiens_hsa051600.65312394
79Purine metabolism_Homo sapiens_hsa002300.65226497
80Primary immunodeficiency_Homo sapiens_hsa053400.65218731
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.64873765
82Herpes simplex infection_Homo sapiens_hsa051680.64261467
83Focal adhesion_Homo sapiens_hsa045100.63999015
84Fatty acid metabolism_Homo sapiens_hsa012120.63785546
85Carbon metabolism_Homo sapiens_hsa012000.63223530
86PPAR signaling pathway_Homo sapiens_hsa033200.61760285
87ECM-receptor interaction_Homo sapiens_hsa045120.61680009
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60824742
89Salmonella infection_Homo sapiens_hsa051320.60548567
90Pancreatic cancer_Homo sapiens_hsa052120.56553601
91Viral carcinogenesis_Homo sapiens_hsa052030.55369117
92Hippo signaling pathway_Homo sapiens_hsa043900.54651838
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.53805557
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52439091
95Insulin resistance_Homo sapiens_hsa049310.51867445
96Selenocompound metabolism_Homo sapiens_hsa004500.50887554
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48598628
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48558330
99Oxidative phosphorylation_Homo sapiens_hsa001900.48372241
100Acute myeloid leukemia_Homo sapiens_hsa052210.48108113
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.47567209
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47550081
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46943154
104Amoebiasis_Homo sapiens_hsa051460.46253567
105Basal cell carcinoma_Homo sapiens_hsa052170.45585688
106Huntingtons disease_Homo sapiens_hsa050160.45286305
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44855410
108Bile secretion_Homo sapiens_hsa049760.44408355
109Lysine degradation_Homo sapiens_hsa003100.42777255
110Endometrial cancer_Homo sapiens_hsa052130.42173781
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41762365
112Pertussis_Homo sapiens_hsa051330.41698414
113mTOR signaling pathway_Homo sapiens_hsa041500.41102391
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40890856
115Thyroid cancer_Homo sapiens_hsa052160.40479110
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.40330936
117* Metabolic pathways_Homo sapiens_hsa011000.38555049
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38456091
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37724124
120Glioma_Homo sapiens_hsa052140.36941046
121Colorectal cancer_Homo sapiens_hsa052100.36772320
122TGF-beta signaling pathway_Homo sapiens_hsa043500.36579187
123Adherens junction_Homo sapiens_hsa045200.34293941
124VEGF signaling pathway_Homo sapiens_hsa043700.33991591
125Small cell lung cancer_Homo sapiens_hsa052220.33238967
126Proteoglycans in cancer_Homo sapiens_hsa052050.32803633
127Oocyte meiosis_Homo sapiens_hsa041140.32700780
128Chronic myeloid leukemia_Homo sapiens_hsa052200.31958637
129HTLV-I infection_Homo sapiens_hsa051660.31339887
130Complement and coagulation cascades_Homo sapiens_hsa046100.31233870
131Glucagon signaling pathway_Homo sapiens_hsa049220.31164009
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.28976457
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27834781
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27349999
135Phagosome_Homo sapiens_hsa041450.26731509
136Systemic lupus erythematosus_Homo sapiens_hsa053220.26206683
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25864556
138Lysosome_Homo sapiens_hsa041420.25861317
139Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24295977
140Collecting duct acid secretion_Homo sapiens_hsa049660.23757078
141Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23372015
142Dilated cardiomyopathy_Homo sapiens_hsa054140.23312147
143Viral myocarditis_Homo sapiens_hsa054160.23229586
144Renin-angiotensin system_Homo sapiens_hsa046140.22153132
145Fatty acid elongation_Homo sapiens_hsa000620.21868639
146Wnt signaling pathway_Homo sapiens_hsa043100.21647644
147Fat digestion and absorption_Homo sapiens_hsa049750.21417397
148Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20842306
149Arginine biosynthesis_Homo sapiens_hsa002200.20612837
150Measles_Homo sapiens_hsa051620.19767992
151Hepatitis B_Homo sapiens_hsa051610.18125206
152Apoptosis_Homo sapiens_hsa042100.17637248

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