ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of metanephros development (GO:0072217)	5.47048815
2	positive regulation of male gonad development (GO:2000020)	5.21363986
3	atrioventricular valve morphogenesis (GO:0003181)	4.97728880
4	epithelial cell differentiation involved in kidney development (GO:0035850)	4.92903329
5	blood coagulation, intrinsic pathway (GO:0007597)	4.82691798
6	endothelium development (GO:0003158)	4.81974157
7	endocardial cushion development (GO:0003197)	4.78325390
8	glyoxylate metabolic process (GO:0046487)	4.74791260
9	protein carboxylation (GO:0018214)	4.69251103
10	peptidyl-glutamic acid carboxylation (GO:0017187)	4.69251103
11	parturition (GO:0007567)	4.68989510
12	seminiferous tubule development (GO:0072520)	4.62324020
13	regulation of cell proliferation involved in kidney development (GO:1901722)	4.57975060
14	metanephric mesenchyme development (GO:0072075)	4.46021077
15	muscle cell fate commitment (GO:0042693)	4.44339619
16	L-phenylalanine catabolic process (GO:0006559)	4.37364277
17	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.37364277
18	mesonephros development (GO:0001823)	4.27782093
19	glomerular basement membrane development (GO:0032836)	4.26774624
20	positive regulation of odontogenesis (GO:0042482)	4.17997885
21	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	4.17003041
22	regulation of male gonad development (GO:2000018)	4.12252988
23	regulation of cardioblast differentiation (GO:0051890)	4.07421192
24	kidney mesenchyme development (GO:0072074)	4.03532076
25	negative regulation of hemostasis (GO:1900047)	3.88977666
26	negative regulation of blood coagulation (GO:0030195)	3.88977666
27	cellular response to gonadotropin stimulus (GO:0071371)	3.88952369
28	sulfation (GO:0051923)	3.78224517
29	fibrinolysis (GO:0042730)	3.77400669
30	regulation of female gonad development (GO:2000194)	3.73882822
31	coenzyme catabolic process (GO:0009109)	3.72365078
32	negative regulation of coagulation (GO:0050819)	3.71309253
33	regulation of protein activation cascade (GO:2000257)	3.70702209
34	ethanol oxidation (GO:0006069)	3.70664258
35	regulation of phospholipase A2 activity (GO:0032429)	3.69177178
36	regulation of glomerulus development (GO:0090192)	3.67834147
37	diaphragm development (GO:0060539)	3.65244114
38	L-phenylalanine metabolic process (GO:0006558)	3.62864810
39	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.62864810
40	drug catabolic process (GO:0042737)	3.62485726
41	blood vessel maturation (GO:0001955)	3.59195528
42	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.57964357
43	negative regulation of macrophage differentiation (GO:0045650)	3.56154873
44	regulation of complement activation (GO:0030449)	3.53522035
45	arginine metabolic process (GO:0006525)	3.53471304
46	oxidative demethylation (GO:0070989)	3.51969420
47	negative regulation of wound healing (GO:0061045)	3.47949595
48	ethanol metabolic process (GO:0006067)	3.40235026
49	epithelial cell fate commitment (GO:0072148)	3.29955457
50	arginine catabolic process (GO:0006527)	3.23388068
51	deoxyribose phosphate catabolic process (GO:0046386)	3.17509256
52	skeletal muscle organ development (GO:0060538)	3.15663235
53	glycine metabolic process (GO:0006544)	3.14579828
54	sulfur amino acid catabolic process (GO:0000098)	3.14454180
55	positive regulation of metanephros development (GO:0072216)	3.14189438
56	cardiac muscle hypertrophy in response to stress (GO:0014898)	3.08576255
57	muscle hypertrophy in response to stress (GO:0003299)	3.08576255
58	cardiac muscle adaptation (GO:0014887)	3.08576255
59	cofactor catabolic process (GO:0051187)	3.07543840
60	urea metabolic process (GO:0019627)	3.04567695
61	fusion of sperm to egg plasma membrane (GO:0007342)	3.04323410
62	aromatic amino acid family catabolic process (GO:0009074)	3.04177554
63	regulation of fibrinolysis (GO:0051917)	3.03754186
64	lymphangiogenesis (GO:0001946)	3.03321523
65	negative regulation of complement activation (GO:0045916)	3.02905239
66	polyketide metabolic process (GO:0030638)	3.02862151
67	doxorubicin metabolic process (GO:0044598)	3.02862151
68	daunorubicin metabolic process (GO:0044597)	3.02862151
69	plasma membrane fusion (GO:0045026)	3.02040141
70	serine family amino acid catabolic process (GO:0009071)	3.01087925
71	purine ribonucleotide transport (GO:0015868)	3.00652885
72	omega-hydroxylase P450 pathway (GO:0097267)	2.99262184
73	regulation of gonadotropin secretion (GO:0032276)	2.99231493
74	metanephric epithelium development (GO:0072207)	2.98442258
75	cardiac right ventricle morphogenesis (GO:0003215)	2.98037486
76	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.96506691
77	mRNA cleavage (GO:0006379)	2.95561862
78	activation of protein kinase B activity (GO:0032148)	2.90625534
79	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	2.89488725
80	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	2.89148082
81	regulation of bile acid biosynthetic process (GO:0070857)	2.87176774
82	alkaloid metabolic process (GO:0009820)	2.86967605
83	bile acid biosynthetic process (GO:0006699)	2.85382039
84	positive regulation of vasculogenesis (GO:2001214)	2.85093789
85	glomerulus development (GO:0032835)	2.83372258
86	negative regulation of kidney development (GO:0090185)	2.81200590
87	positive regulation of urine volume (GO:0035810)	2.81099889
88	negative regulation of protein activation cascade (GO:2000258)	2.81054753
89	urea cycle (GO:0000050)	2.78561853
90	aminoglycoside antibiotic metabolic process (GO:0030647)	2.77307560
91	deoxyribonucleotide catabolic process (GO:0009264)	2.76987637
92	complement activation, alternative pathway (GO:0006957)	2.75295709
93	response to follicle-stimulating hormone (GO:0032354)	2.74670355
94	phenylpropanoid metabolic process (GO:0009698)	2.71323504
95	positive regulation of protein kinase C signaling (GO:0090037)	2.70735830
96	embryonic foregut morphogenesis (GO:0048617)	2.68226813
97	epoxygenase P450 pathway (GO:0019373)	2.68169407
98	nitrogen cycle metabolic process (GO:0071941)	2.66918146
99	androgen biosynthetic process (GO:0006702)	2.65798523
100	L-methionine biosynthetic process (GO:0071265)	2.65629717

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	6.48124406
2	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	4.34312768
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.02498670
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.66905272
5	RXR_22158963_ChIP-Seq_LIVER_Mouse	3.12325498
6	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	3.07388978
7	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.99573554
8	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	2.95900700
9	GATA2_21666600_ChIP-Seq_HMVEC_Human	2.63843912
10	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.58026087
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.46777334
12	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.39843178
13	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.37967524
14	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	2.35594212
15	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.24275028
16	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.23160115
17	GBX2_23144817_ChIP-Seq_PC3_Human	2.21909390
18	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.16880333
19	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.08592223
20	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.06653595
21	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.99001180
22	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.90647472
23	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.88728024
24	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.86648449
25	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.79540553
26	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.78559500
27	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.76219769
28	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.75342255
29	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.65807014
30	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.58501162
31	SPI1_20517297_ChIP-Seq_HL60_Human	1.51824050
32	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.47413249
33	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.36664835
34	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.31932934
35	LXR_22292898_ChIP-Seq_THP-1_Human	1.29158089
36	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.28711787
37	SOX2_20726797_ChIP-Seq_SW620_Human	1.26362288
38	CTCF_27219007_Chip-Seq_Bcells_Human	1.26115266
39	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.24858951
40	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.24314613
41	ZNF263_19887448_ChIP-Seq_K562_Human	1.23934930
42	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.22891308
43	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.21004558
44	BCL6_27268052_Chip-Seq_Bcells_Human	1.20885761
45	ERA_21632823_ChIP-Seq_H3396_Human	1.18160874
46	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.16361455
47	GATA1_22025678_ChIP-Seq_K562_Human	1.15710647
48	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.12525332
49	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.11476908
50	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.11302376
51	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.10487066
52	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.10145814
53	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.09601144
54	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.07967459
55	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.06157062
56	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.05858289
57	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.05719979
58	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.05171586
59	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.04749809
60	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.03769112
61	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.02282086
62	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.01391066
63	RXR_22108803_ChIP-Seq_LS180_Human	1.00793229
64	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.00585752
65	MYC_18940864_ChIP-ChIP_HL60_Human	0.99563816
66	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.98242828
67	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.98242828
68	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.98235474
69	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.97712248
70	SOX2_21211035_ChIP-Seq_LN229_Human	0.96482147
71	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.94234401
72	RAC3_21632823_ChIP-Seq_H3396_Human	0.93323909
73	CTCF_21964334_Chip-Seq_Bcells_Human	0.89942421
74	CJUN_26792858_Chip-Seq_BT549_Human	0.89595964
75	IGF1R_20145208_ChIP-Seq_DFB_Human	0.89162142
76	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.88657570
77	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.88096561
78	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.87242351
79	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.87028590
80	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.86881982
81	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.85104593
82	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.84047762
83	NANOG_20526341_ChIP-Seq_ESCs_Human	0.82977056
84	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.82922865
85	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.82679752
86	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	0.82637438
87	P300_27268052_Chip-Seq_Bcells_Human	0.82577399
88	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.81717274
89	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.81374914
90	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.80642548
91	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.80299714
92	SCL_19346495_ChIP-Seq_HPC-7_Human	0.79071551
93	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.76196448
94	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.76091236
95	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.75726249
96	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.75412350
97	PHF8_20622854_ChIP-Seq_HELA_Human	0.75208390
98	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.74520852
99	CBP_21632823_ChIP-Seq_H3396_Human	0.74248172
100	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.73780710

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010368_abnormal_lymphatic_system	5.03095920
2	MP0009697_abnormal_copulation	4.43582394
3	MP0002132_abnormal_respiratory_system	4.02209587
4	MP0010386_abnormal_urinary_bladder	3.96369698
5	MP0003806_abnormal_nucleotide_metabolis	3.88994138
6	MP0002138_abnormal_hepatobiliary_system	3.69654604
7	MP0004272_abnormal_basement_membrane	3.59087607
8	MP0005360_urolithiasis	3.32695936
9	MP0002139_abnormal_hepatobiliary_system	3.26708963
10	MP0003828_pulmonary_edema	3.25922629
11	MP0009384_cardiac_valve_regurgitation	2.95921233
12	MP0005085_abnormal_gallbladder_physiolo	2.87795921
13	MP0003868_abnormal_feces_composition	2.47126412
14	MP0001661_extended_life_span	2.44148302
15	MP0001879_abnormal_lymphatic_vessel	2.29230245
16	MP0003300_gastrointestinal_ulcer	2.24460588
17	MP0008004_abnormal_stomach_pH	2.19725421
18	MP0003011_delayed_dark_adaptation	2.15512324
19	MP0005365_abnormal_bile_salt	2.13750890
20	MP0003315_abnormal_perineum_morphology	2.09098183
21	MP0000767_abnormal_smooth_muscle	1.90338107
22	MP0005167_abnormal_blood-brain_barrier	1.89745130
23	MP0002127_abnormal_cardiovascular_syste	1.89434510
24	MP0001666_abnormal_nutrient_absorption	1.81970058
25	MP0008875_abnormal_xenobiotic_pharmacok	1.78603218
26	MP0009840_abnormal_foam_cell	1.64595272
27	MP0000013_abnormal_adipose_tissue	1.62578199
28	MP0006138_congestive_heart_failure	1.58223100
29	MP0005646_abnormal_pituitary_gland	1.54051184
30	MP0005595_abnormal_vascular_smooth	1.51827669
31	MP0004019_abnormal_vitamin_homeostasis	1.51602069
32	MP0001764_abnormal_homeostasis	1.49236851
33	MP0005410_abnormal_fertilization	1.42427572
34	MP0005220_abnormal_exocrine_pancreas	1.41234716
35	MP0002295_abnormal_pulmonary_circulatio	1.37129953
36	MP0002160_abnormal_reproductive_system	1.34097772
37	MP0003186_abnormal_redox_activity	1.31925724
38	MP0003724_increased_susceptibility_to	1.25860109
39	MP0001849_ear_inflammation	1.24279754
40	MP0004084_abnormal_cardiac_muscle	1.20561630
41	MP0004484_altered_response_of	1.17454187
42	MP0005389_reproductive_system_phenotype	1.16503842
43	MP0005464_abnormal_platelet_physiology	1.15190321
44	MP0005084_abnormal_gallbladder_morpholo	1.13947298
45	MP0008438_abnormal_cutaneous_collagen	1.07726734
46	MP0000465_gastrointestinal_hemorrhage	1.06886361
47	MP0005165_increased_susceptibility_to	1.04424561
48	MP0002089_abnormal_postnatal_growth/wei	1.00549369
49	MP0000343_altered_response_to	1.00380537
50	MP0004036_abnormal_muscle_relaxation	0.99593037
51	MP0003252_abnormal_bile_duct	0.99227208
52	MP0000249_abnormal_blood_vessel	0.98275533
53	MP0000230_abnormal_systemic_arterial	0.94961751
54	MP0003195_calcinosis	0.92215576
55	MP0003279_aneurysm	0.90931545
56	MP0005166_decreased_susceptibility_to	0.86853305
57	MP0005620_abnormal_muscle_contractility	0.86820182
58	MP0000678_abnormal_parathyroid_gland	0.84384118
59	MP0003950_abnormal_plasma_membrane	0.84031221
60	MP0002128_abnormal_blood_circulation	0.82506294
61	MP0008872_abnormal_physiological_respon	0.81535651
62	MP0010329_abnormal_lipoprotein_level	0.80569961
63	MP0005409_darkened_coat_color	0.79615431
64	MP0000538_abnormal_urinary_bladder	0.79167900
65	MP0008775_abnormal_heart_ventricle	0.77495035
66	MP0003942_abnormal_urinary_system	0.77115207
67	MP0003567_abnormal_fetal_cardiomyocyte	0.77056763
68	MP0009333_abnormal_splenocyte_physiolog	0.76975481
69	MP0003943_abnormal_hepatobiliary_system	0.76927508
70	MP0004782_abnormal_surfactant_physiolog	0.75435998
71	MP0005164_abnormal_response_to	0.72777384
72	MP0002972_abnormal_cardiac_muscle	0.69969684
73	MP0005376_homeostasis/metabolism_phenot	0.69935596
74	MP0001919_abnormal_reproductive_system	0.69916665
75	MP0006036_abnormal_mitochondrial_physio	0.69766296
76	MP0001664_abnormal_digestion	0.69147933
77	MP0001756_abnormal_urination	0.69097762
78	MP0003115_abnormal_respiratory_system	0.69081414
79	MP0008874_decreased_physiological_sensi	0.68544344
80	MP0001544_abnormal_cardiovascular_syste	0.68000967
81	MP0005385_cardiovascular_system_phenoty	0.68000967
82	MP0004883_abnormal_blood_vessel	0.66639876
83	MP0001545_abnormal_hematopoietic_system	0.65262790
84	MP0005397_hematopoietic_system_phenotyp	0.65262790
85	MP0009643_abnormal_urine_homeostasis	0.64365077
86	MP0005187_abnormal_penis_morphology	0.64197978
87	MP0009764_decreased_sensitivity_to	0.63253697
88	MP0005332_abnormal_amino_acid	0.62066533
89	MP0001614_abnormal_blood_vessel	0.61218822
90	MP0003638_abnormal_response/metabolism_	0.60561224
91	MP0003385_abnormal_body_wall	0.59820059
92	MP0005023_abnormal_wound_healing	0.56141720
93	MP0003091_abnormal_cell_migration	0.55938624
94	MP0009763_increased_sensitivity_to	0.55164083
95	MP0008995_early_reproductive_senescence	0.53768362
96	MP0004085_abnormal_heartbeat	0.53175512
97	MP0003191_abnormal_cellular_cholesterol	0.52784380
98	MP0002876_abnormal_thyroid_physiology	0.51565128
99	MP0002133_abnormal_respiratory_system	0.51484937
100	MP0005388_respiratory_system_phenotype	0.51484937

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Gonadal dysgenesis (HP:0000133)	8.86997343
2	Testicular neoplasm (HP:0010788)	7.34567994
3	Mesangial abnormality (HP:0001966)	6.14578924
4	Hypoplastic left heart (HP:0004383)	6.00867177
5	Reduced antithrombin III activity (HP:0001976)	5.07955055
6	Hypoplastic heart (HP:0001961)	4.81829678
7	Anomalous pulmonary venous return (HP:0010772)	4.66370225
8	Protrusio acetabuli (HP:0003179)	4.42504603
9	Sex reversal (HP:0012245)	4.42100216
10	Abnormal sex determination (HP:0012244)	4.42100216
11	Deep venous thrombosis (HP:0002625)	4.19968271
12	Abnormality of the pulmonary veins (HP:0011718)	4.12211708
13	Prolonged partial thromboplastin time (HP:0003645)	3.90643361
14	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.90046349
15	Transposition of the great arteries (HP:0001669)	3.80896145
16	Abnormal connection of the cardiac segments (HP:0011545)	3.80896145
17	Abnormal ventriculo-arterial connection (HP:0011563)	3.80896145
18	Hypoplasia of the uterus (HP:0000013)	3.72643558
19	Germ cell neoplasia (HP:0100728)	3.72537165
20	True hermaphroditism (HP:0010459)	3.56921422
21	Abnormality of the intrinsic pathway (HP:0010989)	3.43360816
22	Male pseudohermaphroditism (HP:0000037)	3.29434891
23	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.21074716
24	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.21074716
25	Aortic aneurysm (HP:0004942)	3.20176700
26	Menorrhagia (HP:0000132)	3.18851073
27	Joint hemorrhage (HP:0005261)	3.17121485
28	Systemic lupus erythematosus (HP:0002725)	3.12762791
29	Abnormality of male internal genitalia (HP:0000022)	3.11992983
30	Female pseudohermaphroditism (HP:0010458)	3.09265713
31	Delayed CNS myelination (HP:0002188)	3.08761398
32	Ileus (HP:0002595)	3.01514679
33	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.95236204
34	Petechiae (HP:0000967)	2.85653028
35	Primary adrenal insufficiency (HP:0008207)	2.84490334
36	Nonimmune hydrops fetalis (HP:0001790)	2.83472512
37	Abnormal pupillary function (HP:0007686)	2.65707069
38	Male infertility (HP:0003251)	2.64931279
39	Bulbar palsy (HP:0001283)	2.55163678
40	Upper motor neuron abnormality (HP:0002127)	2.49859059
41	Abnormality of the peritoneum (HP:0002585)	2.46024858
42	Purpura (HP:0000979)	2.40401957
43	Aplasia/hypoplasia of the uterus (HP:0008684)	2.40047624
44	Abnormality of pyrimidine metabolism (HP:0004353)	2.35923606
45	Rimmed vacuoles (HP:0003805)	2.34942868
46	Abnormality of the lower motor neuron (HP:0002366)	2.31601367
47	Focal segmental glomerulosclerosis (HP:0000097)	2.31349323
48	Prolonged bleeding time (HP:0003010)	2.30896951
49	Beaking of vertebral bodies (HP:0004568)	2.27555842
50	Generalized aminoaciduria (HP:0002909)	2.22734986
51	Aplastic anemia (HP:0001915)	2.20656232
52	Abnormality of dentin (HP:0010299)	2.19185560
53	Glomerulosclerosis (HP:0000096)	2.15158701
54	Portal hypertension (HP:0001409)	2.11589150
55	Thoracic kyphosis (HP:0002942)	2.10610059
56	Complement deficiency (HP:0004431)	2.07816579
57	Preauricular pit (HP:0004467)	2.02876275
58	Periauricular skin pits (HP:0100277)	2.02876275
59	Type I transferrin isoform profile (HP:0003642)	2.02871830
60	Biconcave vertebral bodies (HP:0004586)	1.99101610
61	Abnormality of the columella (HP:0009929)	1.97075514
62	Abnormality of the hepatic vasculature (HP:0006707)	1.96136727
63	Intrahepatic cholestasis (HP:0001406)	1.95838970
64	Ovarian neoplasm (HP:0100615)	1.94976093
65	Renal Fanconi syndrome (HP:0001994)	1.94463895
66	Abnormality of the corticospinal tract (HP:0002492)	1.91447901
67	Epistaxis (HP:0000421)	1.90095714
68	Vertebral compression fractures (HP:0002953)	1.87457818
69	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.86149095
70	Xerostomia (HP:0000217)	1.85186797
71	Hepatocellular necrosis (HP:0001404)	1.84475597
72	Amyotrophic lateral sclerosis (HP:0007354)	1.80919291
73	Hyperlipoproteinemia (HP:0010980)	1.76463025
74	Hypobetalipoproteinemia (HP:0003563)	1.75582340
75	Rickets (HP:0002748)	1.72423775
76	Hepatic necrosis (HP:0002605)	1.70922385
77	Venous insufficiency (HP:0005293)	1.69134086
78	Spinal rigidity (HP:0003306)	1.64802869
79	Right ventricular cardiomyopathy (HP:0011663)	1.64335983
80	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.62195698
81	Abnormality of the prostate (HP:0008775)	1.61179874
82	Hyperammonemia (HP:0001987)	1.59355108
83	Xanthomatosis (HP:0000991)	1.59233558
84	Abnormality of complement system (HP:0005339)	1.58520196
85	Papilledema (HP:0001085)	1.58169739
86	Abnormality of the frontal sinuses (HP:0002687)	1.57207701
87	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.56814500
88	Hydroureter (HP:0000072)	1.56539262
89	High anterior hairline (HP:0009890)	1.56478638
90	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.56218405
91	Dicarboxylic aciduria (HP:0003215)	1.56218405
92	Glycosuria (HP:0003076)	1.53972293
93	Abnormality of urine glucose concentration (HP:0011016)	1.53972293
94	Spondylolisthesis (HP:0003302)	1.53556415
95	Abnormality of fatty-acid metabolism (HP:0004359)	1.52979077
96	High pitched voice (HP:0001620)	1.52338483
97	Osteomalacia (HP:0002749)	1.52152603
98	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.52070528
99	Shoulder girdle muscle weakness (HP:0003547)	1.47872124
100	Abnormality of the Achilles tendon (HP:0005109)	1.47291097

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	4.55924680
2	MYLK	4.09840254
3	LMTK2	4.01420047
4	NME2	3.82616607
5	KDR	3.66127449
6	PINK1	3.07690883
7	FLT3	2.89891648
8	TGFBR1	2.06910349
9	PKN2	2.02012607
10	KIT	1.97455000
11	PRKG2	1.95662552
12	STK38L	1.88736783
13	ARAF	1.84262115
14	LATS1	1.79184337
15	EPHB1	1.73940890
16	CDK8	1.72557367
17	BMPR1B	1.61493453
18	MAP3K1	1.57308815
19	NEK2	1.53193701
20	PIM2	1.52181786
21	TNK2	1.51542050
22	PTK2B	1.47748935
23	SGK494	1.47050160
24	SGK223	1.47050160
25	LATS2	1.46465482
26	FES	1.35009063
27	MAP2K7	1.32477355
28	CDK4	1.30802804
29	MOS	1.30053431
30	TESK2	1.29160840
31	MAP3K5	1.26223344
32	MARK3	1.24856779
33	MAP3K11	1.23291639
34	SGK2	1.22765325
35	TAOK2	1.22553244
36	ERN1	1.22403957
37	GRK1	1.21909300
38	TGFBR2	1.18610890
39	CDK19	1.15252921
40	EIF2AK3	1.13697872
41	NEK9	1.12229745
42	PAK1	1.08148474
43	TRPM7	1.05135679
44	BTK	1.02099920
45	OBSCN	0.99898935
46	DAPK3	0.98299068
47	BCKDK	0.97147366
48	EPHB2	0.95238025
49	MAP4K2	0.95039372
50	MAP3K12	0.93939677
51	ROCK1	0.92865549
52	MAP2K3	0.89954829
53	ILK	0.86890770
54	PRKCQ	0.86309945
55	PRPF4B	0.85125062
56	TBK1	0.84390106
57	PTK2	0.81628546
58	NUAK1	0.80857932
59	PDK2	0.80161239
60	MAPK12	0.73566610
61	VRK2	0.72885237
62	MAP3K6	0.72032925
63	OXSR1	0.70267141
64	GRK6	0.68566189
65	NLK	0.67928441
66	PAK2	0.63587699
67	MELK	0.61363169
68	DYRK2	0.61116531
69	GRK5	0.60617395
70	SGK3	0.58276484
71	TEC	0.55539065
72	ABL2	0.55366255
73	AKT2	0.52726188
74	CSNK1G1	0.52030465
75	ADRBK2	0.46989449
76	MINK1	0.46552919
77	ZAP70	0.45861667
78	JAK3	0.44691389
79	ADRBK1	0.41939195
80	TAOK3	0.41717255
81	AURKA	0.38784367
82	STK38	0.37483227
83	RET	0.37021541
84	TESK1	0.36226535
85	RIPK1	0.35366847
86	BRAF	0.34487857
87	RPS6KA2	0.32835917
88	PRKG1	0.31621770
89	PRKACG	0.30963729
90	CDK7	0.27329725
91	STK3	0.26932528
92	MAPK15	0.26417977
93	FGR	0.24263616
94	CDC42BPA	0.23240455
95	AKT3	0.23234631
96	CDK3	0.23020366
97	CSNK1G3	0.22428412
98	PTK6	0.22142297
99	ROCK2	0.21566526
100	EGFR	0.21233837

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.74013788
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.69127705
3	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	3.51522797
4	Complement and coagulation cascades_Homo sapiens_hsa04610	3.40703247
5	Chemical carcinogenesis_Homo sapiens_hsa05204	3.39339147
6	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	3.03241328
7	Steroid hormone biosynthesis_Homo sapiens_hsa00140	3.00315727
8	Arginine biosynthesis_Homo sapiens_hsa00220	2.64737445
9	Sulfur metabolism_Homo sapiens_hsa00920	2.50120632
10	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.35695967
11	Retinol metabolism_Homo sapiens_hsa00830	2.33643449
12	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.17944572
13	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.08737311
14	Pentose phosphate pathway_Homo sapiens_hsa00030	2.04547936
15	Butanoate metabolism_Homo sapiens_hsa00650	2.01658036
16	Tyrosine metabolism_Homo sapiens_hsa00350	1.95985211
17	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.90767442
18	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.84924869
19	Peroxisome_Homo sapiens_hsa04146	1.84571617
20	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.83084084
21	Glutathione metabolism_Homo sapiens_hsa00480	1.72853410
22	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.72803042
23	Phenylalanine metabolism_Homo sapiens_hsa00360	1.69535331
24	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.67471016
25	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.62647897
26	Fatty acid degradation_Homo sapiens_hsa00071	1.61307229
27	Bile secretion_Homo sapiens_hsa04976	1.53699032
28	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.51224695
29	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.49207202
30	Folate biosynthesis_Homo sapiens_hsa00790	1.47862162
31	Arginine and proline metabolism_Homo sapiens_hsa00330	1.47009702
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.46960690
33	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.44011976
34	ECM-receptor interaction_Homo sapiens_hsa04512	1.28963048
35	Histidine metabolism_Homo sapiens_hsa00340	1.26809258
36	One carbon pool by folate_Homo sapiens_hsa00670	1.23806256
37	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.18210309
38	beta-Alanine metabolism_Homo sapiens_hsa00410	1.13344858
39	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.10945121
40	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.07023072
41	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.05705308
42	Tryptophan metabolism_Homo sapiens_hsa00380	1.03795147
43	PPAR signaling pathway_Homo sapiens_hsa03320	1.01223480
44	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.00851693
45	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.84443798
46	Olfactory transduction_Homo sapiens_hsa04740	0.75278290
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.74486177
48	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.70093933
49	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.70076227
50	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.68335769
51	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.68315118
52	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.67778467
53	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.67262530
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.65125381
55	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.64087678
56	Metabolic pathways_Homo sapiens_hsa01100	0.63261472
57	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.63034780
58	Nitrogen metabolism_Homo sapiens_hsa00910	0.63006050
59	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.62289397
60	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.61758271
61	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.61690609
62	Pertussis_Homo sapiens_hsa05133	0.60730620
63	Platelet activation_Homo sapiens_hsa04611	0.58179312
64	Carbon metabolism_Homo sapiens_hsa01200	0.50310839
65	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.48615455
66	ABC transporters_Homo sapiens_hsa02010	0.48561088
67	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.48055427
68	Focal adhesion_Homo sapiens_hsa04510	0.47604405
69	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.46293419
70	Pyruvate metabolism_Homo sapiens_hsa00620	0.46061457
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.45106795
72	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.44810951
73	Galactose metabolism_Homo sapiens_hsa00052	0.42120974
74	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.39870342
75	Selenocompound metabolism_Homo sapiens_hsa00450	0.39274509
76	Prion diseases_Homo sapiens_hsa05020	0.37999516
77	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.37864306
78	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.37790311
79	Other glycan degradation_Homo sapiens_hsa00511	0.37518368
80	Protein digestion and absorption_Homo sapiens_hsa04974	0.36768404
81	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.34688100
82	Sulfur relay system_Homo sapiens_hsa04122	0.34248515
83	Purine metabolism_Homo sapiens_hsa00230	0.33270031
84	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.32645288
85	Mineral absorption_Homo sapiens_hsa04978	0.32591084
86	Pyrimidine metabolism_Homo sapiens_hsa00240	0.31042858
87	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.30945648
88	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.29780249
89	Sphingolipid metabolism_Homo sapiens_hsa00600	0.29763952
90	Fatty acid elongation_Homo sapiens_hsa00062	0.28998017
91	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.28110398
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.22892777
93	Pancreatic secretion_Homo sapiens_hsa04972	0.22624510
94	Protein export_Homo sapiens_hsa03060	0.22213253
95	Salivary secretion_Homo sapiens_hsa04970	0.21716847
96	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.21352859
97	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.21011278
98	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.19599619
99	Lysine degradation_Homo sapiens_hsa00310	0.18039326
100	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.13626261

GPAA1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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