ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.29099915
2	L-fucose catabolic process (GO:0042355)	4.66421442
3	fucose catabolic process (GO:0019317)	4.66421442
4	L-fucose metabolic process (GO:0042354)	4.66421442
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.43541212
6	axoneme assembly (GO:0035082)	4.37102634
7	cilium or flagellum-dependent cell motility (GO:0001539)	4.29869255
8	epithelial cilium movement (GO:0003351)	4.11639035
9	platelet dense granule organization (GO:0060155)	3.98602736
10	indolalkylamine metabolic process (GO:0006586)	3.92495535
11	parturition (GO:0007567)	3.82823071
12	DNA deamination (GO:0045006)	3.68736353
13	tryptophan catabolic process (GO:0006569)	3.61042700
14	indole-containing compound catabolic process (GO:0042436)	3.61042700
15	indolalkylamine catabolic process (GO:0046218)	3.61042700
16	cilium movement (GO:0003341)	3.56642854
17	tryptophan metabolic process (GO:0006568)	3.54498169
18	axonemal dynein complex assembly (GO:0070286)	3.45485473
19	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.37257147
20	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.37257147
21	NADH dehydrogenase complex assembly (GO:0010257)	3.37257147
22	protein-cofactor linkage (GO:0018065)	3.35063986
23	regulation of cilium movement (GO:0003352)	3.31161344
24	sulfation (GO:0051923)	3.26658367
25	protein complex biogenesis (GO:0070271)	3.25762947
26	preassembly of GPI anchor in ER membrane (GO:0016254)	3.17675209
27	amine catabolic process (GO:0009310)	3.14201439
28	cellular biogenic amine catabolic process (GO:0042402)	3.14201439
29	negative regulation of telomere maintenance (GO:0032205)	3.08925986
30	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.04783641
31	kynurenine metabolic process (GO:0070189)	3.04682468
32	adaptation of signaling pathway (GO:0023058)	3.04423404
33	indole-containing compound metabolic process (GO:0042430)	3.03530453
34	mitochondrial respiratory chain complex assembly (GO:0033108)	3.01474298
35	estrogen biosynthetic process (GO:0006703)	2.99583268
36	cellular ketone body metabolic process (GO:0046950)	2.95359639
37	arginine catabolic process (GO:0006527)	2.92980823
38	protein polyglutamylation (GO:0018095)	2.92677058
39	exogenous drug catabolic process (GO:0042738)	2.92437582
40	kidney morphogenesis (GO:0060993)	2.92200517
41	water-soluble vitamin biosynthetic process (GO:0042364)	2.91074905
42	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.90845100
43	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.90845100
44	cysteine metabolic process (GO:0006534)	2.90498065
45	nonmotile primary cilium assembly (GO:0035058)	2.89202133
46	respiratory chain complex IV assembly (GO:0008535)	2.85787155
47	GPI anchor metabolic process (GO:0006505)	2.81829678
48	arginine metabolic process (GO:0006525)	2.81282876
49	glycerophospholipid catabolic process (GO:0046475)	2.78987812
50	primary amino compound metabolic process (GO:1901160)	2.77356471
51	cornea development in camera-type eye (GO:0061303)	2.77338742
52	positive regulation of fatty acid transport (GO:2000193)	2.77315546
53	drug catabolic process (GO:0042737)	2.74725643
54	piRNA metabolic process (GO:0034587)	2.71952158
55	negative regulation of mast cell activation (GO:0033004)	2.71482696
56	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.71370332
57	aromatic amino acid family catabolic process (GO:0009074)	2.70884603
58	regulation of microtubule-based movement (GO:0060632)	2.66776729
59	organic cation transport (GO:0015695)	2.66675504
60	retinal cone cell development (GO:0046549)	2.65925253
61	synaptic transmission, cholinergic (GO:0007271)	2.65518002
62	serine family amino acid catabolic process (GO:0009071)	2.65387550
63	cellular response to ATP (GO:0071318)	2.63362996
64	endoderm formation (GO:0001706)	2.63213218
65	S-adenosylmethionine metabolic process (GO:0046500)	2.63204698
66	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.62750300
67	multicellular organism reproduction (GO:0032504)	2.61921413
68	positive regulation of prostaglandin secretion (GO:0032308)	2.61803793
69	cilium morphogenesis (GO:0060271)	2.61547417
70	response to pheromone (GO:0019236)	2.60889086
71	ubiquinone biosynthetic process (GO:0006744)	2.57992835
72	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.57905025
73	cytidine deamination (GO:0009972)	2.57275357
74	cytidine metabolic process (GO:0046087)	2.57275357
75	cytidine catabolic process (GO:0006216)	2.57275357
76	ketone body metabolic process (GO:1902224)	2.56742535
77	cytochrome complex assembly (GO:0017004)	2.56614189
78	basic amino acid transport (GO:0015802)	2.54628722
79	fucosylation (GO:0036065)	2.54081468
80	cilium organization (GO:0044782)	2.52977174
81	positive regulation of icosanoid secretion (GO:0032305)	2.52272104
82	DNA methylation involved in gamete generation (GO:0043046)	2.51299767
83	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.49991969
84	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.48659620
85	nephron tubule morphogenesis (GO:0072078)	2.47425481
86	nephron epithelium morphogenesis (GO:0072088)	2.47425481
87	hindbrain development (GO:0030902)	2.44985830
88	sperm motility (GO:0030317)	2.44839920
89	motile cilium assembly (GO:0044458)	2.43578355
90	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.43316596
91	ATP synthesis coupled proton transport (GO:0015986)	2.43316596
92	regulation of action potential (GO:0098900)	2.42705961
93	neuronal action potential (GO:0019228)	2.40766403
94	regulation of neurotransmitter uptake (GO:0051580)	2.40575820
95	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.40460606
96	positive regulation of defense response to virus by host (GO:0002230)	2.39247928
97	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.39171092
98	regulation of memory T cell differentiation (GO:0043380)	2.39115255
99	cilium assembly (GO:0042384)	2.36333938
100	cell proliferation in forebrain (GO:0021846)	2.35687684

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.93248181
2	VDR_22108803_ChIP-Seq_LS180_Human	3.40773436
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.96614711
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.81249932
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.50892775
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.47280348
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.44674153
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.23583420
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.14341272
10	IRF1_19129219_ChIP-ChIP_H3396_Human	2.06430241
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.01339690
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.98782374
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.94710646
14	IGF1R_20145208_ChIP-Seq_DFB_Human	1.88836219
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.86966299
16	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.77536669
17	P300_19829295_ChIP-Seq_ESCs_Human	1.74853045
18	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.68758522
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.66145403
20	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.61875262
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.61158807
22	EWS_26573619_Chip-Seq_HEK293_Human	1.60300459
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.58611983
24	TP53_22573176_ChIP-Seq_HFKS_Human	1.53279712
25	BCAT_22108803_ChIP-Seq_LS180_Human	1.50825192
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.49391971
27	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.46564982
28	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.46504617
29	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.45006234
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.44831017
31	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.43883070
32	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.42885254
33	ERA_21632823_ChIP-Seq_H3396_Human	1.39831888
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.39456472
35	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.39356122
36	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.38162450
37	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.37507394
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.37507394
39	NANOG_20526341_ChIP-Seq_ESCs_Human	1.36328420
40	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.33781633
41	TAF2_19829295_ChIP-Seq_ESCs_Human	1.31897035
42	HOXB7_26014856_ChIP-Seq_BT474_Human	1.31623064
43	NCOR_22424771_ChIP-Seq_293T_Human	1.30406446
44	RNF2_27304074_Chip-Seq_NSC_Mouse	1.29492659
45	CBP_20019798_ChIP-Seq_JUKART_Human	1.28938080
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.28938080
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.27226804
48	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.26714709
49	TCF4_22108803_ChIP-Seq_LS180_Human	1.26522920
50	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.23572113
51	FUS_26573619_Chip-Seq_HEK293_Human	1.21544792
52	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.21455764
53	MYC_19829295_ChIP-Seq_ESCs_Human	1.21232906
54	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.21175596
55	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.21163943
56	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.20842473
57	REST_21632747_ChIP-Seq_MESCs_Mouse	1.19341137
58	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.18929152
59	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.18762370
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18717458
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18717458
62	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.17439630
63	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.15928212
64	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.15868342
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15592342
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14318271
67	AR_25329375_ChIP-Seq_VCAP_Human	1.14221366
68	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.13535457
69	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13123883
70	AR_20517297_ChIP-Seq_VCAP_Human	1.13019598
71	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.12918132
72	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.12791757
73	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.12347884
74	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.11429656
75	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.11178714
76	STAT3_23295773_ChIP-Seq_U87_Human	1.10686964
77	SMAD4_21799915_ChIP-Seq_A2780_Human	1.10534673
78	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.10207401
79	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09498326
80	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.09300061
81	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09300061
82	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.09087577
83	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.06764879
84	TCF4_23295773_ChIP-Seq_U87_Human	1.06415728
85	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.05911597
86	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.04400200
87	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.03844098
88	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.02910300
89	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.02439090
90	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.00827461
91	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.99907187
92	OCT4_20526341_ChIP-Seq_ESCs_Human	0.99630447
93	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.99219557
94	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.98492766
95	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.98061070
96	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.97272512
97	CDX2_22108803_ChIP-Seq_LS180_Human	0.97065487
98	RAC3_21632823_ChIP-Seq_H3396_Human	0.96504483
99	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.96048645
100	P53_21459846_ChIP-Seq_SAOS-2_Human	0.95254181

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.34665590
2	MP0005646_abnormal_pituitary_gland	3.00380727
3	MP0003011_delayed_dark_adaptation	2.80297006
4	MP0002876_abnormal_thyroid_physiology	2.50939635
5	MP0008875_abnormal_xenobiotic_pharmacok	2.43330991
6	MP0005551_abnormal_eye_electrophysiolog	2.33270107
7	MP0010386_abnormal_urinary_bladder	2.27794694
8	MP0008877_abnormal_DNA_methylation	2.15223202
9	MP0006292_abnormal_olfactory_placode	2.13531646
10	MP0002653_abnormal_ependyma_morphology	2.12827812
11	MP0004133_heterotaxia	2.12276215
12	MP0002102_abnormal_ear_morphology	2.11172078
13	MP0008872_abnormal_physiological_respon	2.09829337
14	MP0005084_abnormal_gallbladder_morpholo	2.03030862
15	MP0003787_abnormal_imprinting	2.01574602
16	MP0002938_white_spotting	1.99476909
17	MP0006072_abnormal_retinal_apoptosis	1.95646488
18	MP0002837_dystrophic_cardiac_calcinosis	1.93772372
19	MP0002138_abnormal_hepatobiliary_system	1.92181006
20	MP0003136_yellow_coat_color	1.87956257
21	MP0001968_abnormal_touch/_nociception	1.82164152
22	MP0004885_abnormal_endolymph	1.81776614
23	MP0005253_abnormal_eye_physiology	1.80311020
24	MP0002160_abnormal_reproductive_system	1.78419059
25	MP0003646_muscle_fatigue	1.71421541
26	MP0001502_abnormal_circadian_rhythm	1.68499362
27	MP0005085_abnormal_gallbladder_physiolo	1.66032684
28	MP0002736_abnormal_nociception_after	1.65144170
29	MP0001501_abnormal_sleep_pattern	1.63859706
30	MP0005389_reproductive_system_phenotype	1.58726455
31	MP0005645_abnormal_hypothalamus_physiol	1.56310558
32	MP0006276_abnormal_autonomic_nervous	1.56147720
33	MP0008995_early_reproductive_senescence	1.53661324
34	MP0001986_abnormal_taste_sensitivity	1.52338627
35	MP0005365_abnormal_bile_salt	1.48874362
36	MP0005360_urolithiasis	1.47040539
37	MP0002272_abnormal_nervous_system	1.44453053
38	MP0008775_abnormal_heart_ventricle	1.44347205
39	MP0005332_abnormal_amino_acid	1.36529450
40	MP0002638_abnormal_pupillary_reflex	1.36329524
41	MP0003806_abnormal_nucleotide_metabolis	1.35859208
42	MP0001919_abnormal_reproductive_system	1.31121336
43	MP0000631_abnormal_neuroendocrine_gland	1.28227434
44	MP0009745_abnormal_behavioral_response	1.26901230
45	MP0004019_abnormal_vitamin_homeostasis	1.26475990
46	MP0005410_abnormal_fertilization	1.25149986
47	MP0004043_abnormal_pH_regulation	1.23792587
48	MP0000230_abnormal_systemic_arterial	1.23786491
49	MP0001486_abnormal_startle_reflex	1.21496366
50	MP0005167_abnormal_blood-brain_barrier	1.20218031
51	MP0002557_abnormal_social/conspecific_i	1.19205042
52	MP0001485_abnormal_pinna_reflex	1.19080416
53	MP0001905_abnormal_dopamine_level	1.18929752
54	MP0000372_irregular_coat_pigmentation	1.18780598
55	MP0009046_muscle_twitch	1.18316500
56	MP0000049_abnormal_middle_ear	1.17509161
57	MP0002277_abnormal_respiratory_mucosa	1.17141724
58	MP0004142_abnormal_muscle_tone	1.11735906
59	MP0004147_increased_porphyrin_level	1.11492677
60	MP0000026_abnormal_inner_ear	1.08004744
61	MP0001764_abnormal_homeostasis	1.06151625
62	MP0005195_abnormal_posterior_eye	1.03478308
63	MP0002928_abnormal_bile_duct	1.01617130
64	MP0005174_abnormal_tail_pigmentation	1.01094395
65	MP0001756_abnormal_urination	1.00428754
66	MP0004145_abnormal_muscle_electrophysio	1.00420490
67	MP0002572_abnormal_emotion/affect_behav	0.99281773
68	MP0000427_abnormal_hair_cycle	0.99084394
69	MP0010329_abnormal_lipoprotein_level	0.97694435
70	MP0003879_abnormal_hair_cell	0.94962482
71	MP0003718_maternal_effect	0.91892964
72	MP0001963_abnormal_hearing_physiology	0.89618129
73	MP0003186_abnormal_redox_activity	0.88339110
74	MP0004742_abnormal_vestibular_system	0.87894458
75	MP0003938_abnormal_ear_development	0.87118053
76	MP0003283_abnormal_digestive_organ	0.86227019
77	MP0003119_abnormal_digestive_system	0.86130804
78	MP0000013_abnormal_adipose_tissue	0.85178111
79	MP0001440_abnormal_grooming_behavior	0.83462882
80	MP0003878_abnormal_ear_physiology	0.82519223
81	MP0005377_hearing/vestibular/ear_phenot	0.82519223
82	MP0002752_abnormal_somatic_nervous	0.82259556
83	MP0003315_abnormal_perineum_morphology	0.80382897
84	MP0002909_abnormal_adrenal_gland	0.79353957
85	MP0002067_abnormal_sensory_capabilities	0.79293160
86	MP0001529_abnormal_vocalization	0.79061829
87	MP0002064_seizures	0.78575326
88	MP0002735_abnormal_chemical_nociception	0.77988218
89	MP0003698_abnormal_male_reproductive	0.77922264
90	MP0005386_behavior/neurological_phenoty	0.77202717
91	MP0004924_abnormal_behavior	0.77202717
92	MP0001664_abnormal_digestion	0.77033461
93	MP0001944_abnormal_pancreas_morphology	0.76240201
94	MP0002163_abnormal_gland_morphology	0.74852993
95	MP0000538_abnormal_urinary_bladder	0.74161973
96	MP0001324_abnormal_eye_pigmentation	0.74155823
97	MP0000566_synostosis	0.73910261
98	MP0002693_abnormal_pancreas_physiology	0.73763307
99	MP0002184_abnormal_innervation	0.73600877
100	MP0002210_abnormal_sex_determination	0.73598891

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.33768920
2	Abnormality of alanine metabolism (HP:0010916)	4.33768920
3	Hyperalaninemia (HP:0003348)	4.33768920
4	Abnormality of midbrain morphology (HP:0002418)	4.27857266
5	Molar tooth sign on MRI (HP:0002419)	4.27857266
6	Pancreatic cysts (HP:0001737)	3.90930773
7	Nephronophthisis (HP:0000090)	3.87459688
8	Absent/shortened dynein arms (HP:0200106)	3.76615770
9	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.76615770
10	True hermaphroditism (HP:0010459)	3.65520416
11	Pancreatic fibrosis (HP:0100732)	3.61283072
12	Abnormal rod and cone electroretinograms (HP:0008323)	3.47187546
13	Congenital stationary night blindness (HP:0007642)	3.37594017
14	Abnormal respiratory motile cilium morphology (HP:0005938)	3.30376281
15	Abnormal respiratory epithelium morphology (HP:0012253)	3.30376281
16	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.29933400
17	Abnormality of the renal medulla (HP:0100957)	3.22579240
18	Polydipsia (HP:0001959)	3.12806465
19	Abnormal drinking behavior (HP:0030082)	3.12806465
20	Pendular nystagmus (HP:0012043)	3.01515371
21	Chronic hepatic failure (HP:0100626)	2.98608380
22	Attenuation of retinal blood vessels (HP:0007843)	2.96849538
23	Abnormality of the renal cortex (HP:0011035)	2.96841498
24	Abolished electroretinogram (ERG) (HP:0000550)	2.86525331
25	Medial flaring of the eyebrow (HP:0010747)	2.84615599
26	Hypomagnesemia (HP:0002917)	2.79419471
27	Tubular atrophy (HP:0000092)	2.77835497
28	Decreased central vision (HP:0007663)	2.77079610
29	Abnormal ciliary motility (HP:0012262)	2.76169357
30	Type II lissencephaly (HP:0007260)	2.60837708
31	Keratoconus (HP:0000563)	2.53987106
32	Increased corneal curvature (HP:0100692)	2.53987106
33	Tetany (HP:0001281)	2.51867844
34	Polyuria (HP:0000103)	2.48945406
35	Hyperventilation (HP:0002883)	2.44797116
36	Renal cortical cysts (HP:0000803)	2.44582210
37	Cystic liver disease (HP:0006706)	2.44468746
38	Congenital sensorineural hearing impairment (HP:0008527)	2.37739988
39	Hypothermia (HP:0002045)	2.36599888
40	Methylmalonic aciduria (HP:0012120)	2.35231004
41	Methylmalonic acidemia (HP:0002912)	2.30233345
42	Abnormal respiratory motile cilium physiology (HP:0012261)	2.27170283
43	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.24312982
44	Gait imbalance (HP:0002141)	2.20925428
45	3-Methylglutaconic aciduria (HP:0003535)	2.20289369
46	Sclerocornea (HP:0000647)	2.19959082
47	Abnormality of magnesium homeostasis (HP:0004921)	2.18918218
48	Male pseudohermaphroditism (HP:0000037)	2.16670859
49	Ketosis (HP:0001946)	2.13221171
50	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.10820278
51	Hepatocellular necrosis (HP:0001404)	2.09564482
52	Clumsiness (HP:0002312)	2.06770291
53	Abnormal urine output (HP:0012590)	2.06453172
54	Aplasia/hypoplasia of the uterus (HP:0008684)	2.04392424
55	Mitochondrial inheritance (HP:0001427)	2.03690450
56	Congenital primary aphakia (HP:0007707)	2.03345627
57	Anencephaly (HP:0002323)	2.03266784
58	Tubulointerstitial nephritis (HP:0001970)	1.97812777
59	Large for gestational age (HP:0001520)	1.96588049
60	Stomach cancer (HP:0012126)	1.96303229
61	Nephrogenic diabetes insipidus (HP:0009806)	1.93420896
62	Bony spicule pigmentary retinopathy (HP:0007737)	1.92350346
63	Bile duct proliferation (HP:0001408)	1.89549404
64	Abnormal biliary tract physiology (HP:0012439)	1.89549404
65	Conical tooth (HP:0000698)	1.88132233
66	Congenital hepatic fibrosis (HP:0002612)	1.87066053
67	Hepatic necrosis (HP:0002605)	1.86490169
68	Abnormality of renal excretion (HP:0011036)	1.86238074
69	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.85484572
70	Inability to walk (HP:0002540)	1.85073213
71	Hypoplasia of the uterus (HP:0000013)	1.83553615
72	Congenital, generalized hypertrichosis (HP:0004540)	1.82524261
73	Delayed CNS myelination (HP:0002188)	1.81233840
74	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.80157416
75	Acute necrotizing encephalopathy (HP:0006965)	1.79941550
76	Chorioretinal atrophy (HP:0000533)	1.77581986
77	Increased CSF lactate (HP:0002490)	1.76931445
78	Tachypnea (HP:0002789)	1.76374749
79	Cerebellar dysplasia (HP:0007033)	1.76229287
80	Asplenia (HP:0001746)	1.75872136
81	Optic disc pallor (HP:0000543)	1.75801255
82	Occipital encephalocele (HP:0002085)	1.75145471
83	Thyroid-stimulating hormone excess (HP:0002925)	1.74112099
84	Rib fusion (HP:0000902)	1.73983312
85	Abnormality of serum amino acid levels (HP:0003112)	1.72195666
86	Abnormal number of erythroid precursors (HP:0012131)	1.68711698
87	Concave nail (HP:0001598)	1.68480178
88	Abnormality of DNA repair (HP:0003254)	1.66730193
89	Patellar aplasia (HP:0006443)	1.66567029
90	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.65277261
91	Constricted visual fields (HP:0001133)	1.65225840
92	Increased serum lactate (HP:0002151)	1.65183109
93	Hyperglycinuria (HP:0003108)	1.64616664
94	Pigmentary retinal degeneration (HP:0001146)	1.63651763
95	Aplastic anemia (HP:0001915)	1.63120983
96	Stage 5 chronic kidney disease (HP:0003774)	1.61211736
97	Aplasia/Hypoplasia of the patella (HP:0006498)	1.60402075
98	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.60081449
99	Hypoplasia of the fovea (HP:0007750)	1.60081449
100	Abnormal mitochondria in muscle tissue (HP:0008316)	1.59300717

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	3.72778822
2	ADRBK2	3.66749217
3	FRK	3.39029422
4	TLK1	3.17607069
5	TAOK3	2.92090543
6	GRK1	2.87826355
7	NUAK1	2.76745317
8	BMPR1B	2.71689159
9	WNK4	2.21531757
10	STK16	2.11939744
11	ZAK	2.11104205
12	WNK3	2.04265154
13	MAP4K2	2.01733666
14	TIE1	1.77959285
15	MUSK	1.77902903
16	ACVR1B	1.73061871
17	MAPK13	1.69811529
18	MAP2K7	1.69319083
19	CASK	1.64439155
20	MAPK15	1.58964683
21	DYRK2	1.52375563
22	PIK3CA	1.38494690
23	BCKDK	1.37939834
24	ADRBK1	1.37322196
25	DAPK2	1.36127681
26	MAP3K4	1.35846190
27	INSRR	1.24676337
28	TGFBR1	1.22344626
29	PRKCQ	1.21518572
30	PAK3	1.21047555
31	TXK	1.16762380
32	VRK2	1.08366990
33	VRK1	1.08091777
34	NEK2	1.06551917
35	MAP2K2	1.01271678
36	STK39	1.00852164
37	PRKCE	0.95588594
38	PRKCG	0.95051168
39	IRAK1	0.94966176
40	OXSR1	0.92978903
41	IKBKB	0.90315158
42	KIT	0.88731436
43	OBSCN	0.83664781
44	TEC	0.81427127
45	PRKCI	0.80173142
46	EPHB2	0.77023432
47	SGK494	0.74712742
48	SGK223	0.74712742
49	RPS6KA5	0.74002354
50	PHKG2	0.72421437
51	PHKG1	0.72421437
52	MYLK	0.72328374
53	PTK2B	0.71548067
54	CSNK1G2	0.71302391
55	NLK	0.71166357
56	MARK1	0.70655338
57	KDR	0.68276025
58	MAPKAPK3	0.66554269
59	MARK3	0.63027742
60	NTRK2	0.60385310
61	CAMK1	0.56681813
62	EPHA3	0.55951285
63	PRKACA	0.55396675
64	SGK2	0.54886222
65	LIMK1	0.54410941
66	FLT3	0.53977990
67	GRK6	0.53954649
68	PKN1	0.53343031
69	CSNK1A1	0.53031593
70	IKBKE	0.51324031
71	MAP2K6	0.50392572
72	STK38L	0.50047868
73	CSNK1G1	0.49707829
74	MAP3K11	0.46924766
75	CAMK2A	0.45604419
76	ITK	0.45415688
77	GRK7	0.45348991
78	CDK3	0.44072927
79	PRKCA	0.43540576
80	SYK	0.43186287
81	STK11	0.42128368
82	CSNK1G3	0.41979911
83	ABL2	0.40646932
84	PRKG1	0.40236544
85	TNIK	0.40057849
86	MST4	0.38530580
87	PLK4	0.36688643
88	PLK2	0.36487493
89	NTRK3	0.36235763
90	BTK	0.35453643
91	CAMK2D	0.35262321
92	GRK5	0.34354230
93	RPS6KA6	0.33695245
94	CAMKK2	0.32203780
95	TRPM7	0.32175910
96	PIM2	0.31006444
97	CSNK1A1L	0.30776449
98	PASK	0.28941757
99	TESK2	0.28748339
100	ILK	0.28076956

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Linoleic acid metabolism_Homo sapiens_hsa00591	2.83023406
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.80411479
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.77509539
4	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.67091739
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.46647633
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.39012204
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.38818510
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.24552983
9	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.15772649
10	Phototransduction_Homo sapiens_hsa04744	2.13345638
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.12109283
12	Butanoate metabolism_Homo sapiens_hsa00650	2.11841317
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.04803924
14	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.99444419
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.80670055
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.80355577
17	Ether lipid metabolism_Homo sapiens_hsa00565	1.70049851
18	Peroxisome_Homo sapiens_hsa04146	1.68821180
19	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.68734257
20	Chemical carcinogenesis_Homo sapiens_hsa05204	1.66145532
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.65860708
22	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.61247634
23	Parkinsons disease_Homo sapiens_hsa05012	1.60873529
24	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.59896768
25	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.59558924
26	Caffeine metabolism_Homo sapiens_hsa00232	1.59201656
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.58749551
28	Retinol metabolism_Homo sapiens_hsa00830	1.52138146
29	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.49352059
30	Nicotine addiction_Homo sapiens_hsa05033	1.48201906
31	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.36030408
32	Propanoate metabolism_Homo sapiens_hsa00640	1.35795550
33	Basal transcription factors_Homo sapiens_hsa03022	1.35249140
34	Sulfur relay system_Homo sapiens_hsa04122	1.31214574
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.26266193
36	Olfactory transduction_Homo sapiens_hsa04740	1.21266788
37	One carbon pool by folate_Homo sapiens_hsa00670	1.13391393
38	Taste transduction_Homo sapiens_hsa04742	1.13369934
39	Ribosome_Homo sapiens_hsa03010	1.09308986
40	Protein export_Homo sapiens_hsa03060	1.09137591
41	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.08374564
42	Huntingtons disease_Homo sapiens_hsa05016	1.08073523
43	Fat digestion and absorption_Homo sapiens_hsa04975	1.08037899
44	Cardiac muscle contraction_Homo sapiens_hsa04260	1.03855361
45	Homologous recombination_Homo sapiens_hsa03440	1.03363589
46	Morphine addiction_Homo sapiens_hsa05032	1.02356800
47	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.00530707
48	Primary immunodeficiency_Homo sapiens_hsa05340	0.99622886
49	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.97149108
50	RNA polymerase_Homo sapiens_hsa03020	0.94728228
51	Fanconi anemia pathway_Homo sapiens_hsa03460	0.92131836
52	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.91523187
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.91232686
54	Fatty acid degradation_Homo sapiens_hsa00071	0.90233962
55	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.90067989
56	Alzheimers disease_Homo sapiens_hsa05010	0.89733398
57	Serotonergic synapse_Homo sapiens_hsa04726	0.85994114
58	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.85112823
59	GABAergic synapse_Homo sapiens_hsa04727	0.84531275
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.83210852
61	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.83207674
62	Sulfur metabolism_Homo sapiens_hsa00920	0.76552745
63	ABC transporters_Homo sapiens_hsa02010	0.76031381
64	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.75723407
65	RNA degradation_Homo sapiens_hsa03018	0.74751860
66	Histidine metabolism_Homo sapiens_hsa00340	0.74472869
67	Metabolic pathways_Homo sapiens_hsa01100	0.74309493
68	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.71512469
69	Circadian entrainment_Homo sapiens_hsa04713	0.69899234
70	Regulation of autophagy_Homo sapiens_hsa04140	0.68054455
71	Insulin secretion_Homo sapiens_hsa04911	0.66504386
72	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.61166008
73	Collecting duct acid secretion_Homo sapiens_hsa04966	0.60905748
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.60887361
75	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.60632382
76	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.59843960
77	Mineral absorption_Homo sapiens_hsa04978	0.58981168
78	Arginine biosynthesis_Homo sapiens_hsa00220	0.58315538
79	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.58005581
80	Glutamatergic synapse_Homo sapiens_hsa04724	0.56169550
81	Purine metabolism_Homo sapiens_hsa00230	0.55295931
82	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.55096112
83	Arginine and proline metabolism_Homo sapiens_hsa00330	0.51187602
84	Sphingolipid metabolism_Homo sapiens_hsa00600	0.47779628
85	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.47761195
86	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.47270844
87	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.46288124
88	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.44716498
89	Salivary secretion_Homo sapiens_hsa04970	0.43464882
90	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.41583184
91	Tyrosine metabolism_Homo sapiens_hsa00350	0.41224004
92	Glutathione metabolism_Homo sapiens_hsa00480	0.41084710
93	Cocaine addiction_Homo sapiens_hsa05030	0.39366202
94	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38537118
95	Calcium signaling pathway_Homo sapiens_hsa04020	0.37895941
96	PPAR signaling pathway_Homo sapiens_hsa03320	0.37314715
97	Circadian rhythm_Homo sapiens_hsa04710	0.35584541
98	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.35134768
99	Pyrimidine metabolism_Homo sapiens_hsa00240	0.32723105
100	Asthma_Homo sapiens_hsa05310	0.32634742

GPAA1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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