GPALPP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.79822196
2DNA deamination (GO:0045006)5.24520638
3ribosome assembly (GO:0042255)4.54087280
4ribosomal small subunit assembly (GO:0000028)4.38728611
5L-fucose catabolic process (GO:0042355)4.19682140
6fucose catabolic process (GO:0019317)4.19682140
7L-fucose metabolic process (GO:0042354)4.19682140
8regulation of nuclear cell cycle DNA replication (GO:0033262)3.91411593
9response to pheromone (GO:0019236)3.91131019
10telomere maintenance via semi-conservative replication (GO:0032201)3.85759447
11proteasome assembly (GO:0043248)3.78856922
12telomere maintenance via recombination (GO:0000722)3.69384522
13kinetochore assembly (GO:0051382)3.63582504
14regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.61450777
15sulfation (GO:0051923)3.60331388
16kinetochore organization (GO:0051383)3.59409988
17negative regulation of telomere maintenance (GO:0032205)3.55368121
18gamma-aminobutyric acid transport (GO:0015812)3.55135855
19CENP-A containing nucleosome assembly (GO:0034080)3.54657542
20DNA double-strand break processing (GO:0000729)3.51272681
21DNA strand elongation involved in DNA replication (GO:0006271)3.50130931
22kynurenine metabolic process (GO:0070189)3.48401078
23somite development (GO:0061053)3.46422285
24indole-containing compound catabolic process (GO:0042436)3.45136403
25indolalkylamine catabolic process (GO:0046218)3.45136403
26tryptophan catabolic process (GO:0006569)3.45136403
27neural tube formation (GO:0001841)3.44427012
28DNA replication checkpoint (GO:0000076)3.41223606
29detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.39912964
30ribosomal large subunit biogenesis (GO:0042273)3.39372163
31DNA strand elongation (GO:0022616)3.37125268
32mitotic recombination (GO:0006312)3.36733652
33chromatin remodeling at centromere (GO:0031055)3.32442296
34ribosome biogenesis (GO:0042254)3.31846717
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.31673475
36maturation of SSU-rRNA (GO:0030490)3.31269392
37DNA replication initiation (GO:0006270)3.30881315
38indolalkylamine metabolic process (GO:0006586)3.30877616
39telomere maintenance via telomere lengthening (GO:0010833)3.24331476
40regulation of DNA endoreduplication (GO:0032875)3.22010331
41ribonucleoprotein complex biogenesis (GO:0022613)3.20176924
42negative regulation of DNA-dependent DNA replication (GO:2000104)3.16118804
43water-soluble vitamin biosynthetic process (GO:0042364)3.13310818
44DNA-dependent DNA replication (GO:0006261)3.13164759
45replication fork processing (GO:0031297)3.12715802
46mitotic metaphase plate congression (GO:0007080)3.12636645
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.08757783
48mitochondrial respiratory chain complex I assembly (GO:0032981)3.08757783
49NADH dehydrogenase complex assembly (GO:0010257)3.08757783
50protein polyglutamylation (GO:0018095)3.05687759
51negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.03868141
52negative regulation of translation, ncRNA-mediated (GO:0040033)3.03868141
53regulation of translation, ncRNA-mediated (GO:0045974)3.03868141
54kidney morphogenesis (GO:0060993)3.03087771
55regulation of helicase activity (GO:0051095)3.00890859
56negative regulation of transcription regulatory region DNA binding (GO:2000678)3.00715939
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.99348915
58regulation of centriole replication (GO:0046599)2.98811647
59DNA synthesis involved in DNA repair (GO:0000731)2.97411600
60tryptophan metabolic process (GO:0006568)2.96235474
61DNA replication-independent nucleosome assembly (GO:0006336)2.92733431
62DNA replication-independent nucleosome organization (GO:0034724)2.92733431
63interkinetic nuclear migration (GO:0022027)2.92086941
64DNA catabolic process, exonucleolytic (GO:0000738)2.89861531
65transcription elongation from RNA polymerase III promoter (GO:0006385)2.89364475
66termination of RNA polymerase III transcription (GO:0006386)2.89364475
67deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.89005898
68cell proliferation in forebrain (GO:0021846)2.88884658
69rRNA catabolic process (GO:0016075)2.88430364
70meiotic chromosome segregation (GO:0045132)2.88166053
71regulation of double-strand break repair via homologous recombination (GO:0010569)2.88074549
72deoxyribonucleotide biosynthetic process (GO:0009263)2.85856030
73detection of light stimulus involved in visual perception (GO:0050908)2.85563850
74detection of light stimulus involved in sensory perception (GO:0050962)2.85563850
75neuronal action potential (GO:0019228)2.84378311
76rRNA modification (GO:0000154)2.83443091
77protein complex biogenesis (GO:0070271)2.83176700
78mitochondrial DNA replication (GO:0006264)2.82742534
79ribosomal small subunit biogenesis (GO:0042274)2.82673401
80primary amino compound metabolic process (GO:1901160)2.81922711
81regulation of posttranscriptional gene silencing (GO:0060147)2.81791314
82regulation of gene silencing by miRNA (GO:0060964)2.81791314
83regulation of gene silencing by RNA (GO:0060966)2.81791314
84regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.81215678
85negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.79871026
86negative regulation of sister chromatid segregation (GO:0033046)2.79871026
87negative regulation of mitotic sister chromatid separation (GO:2000816)2.79871026
88negative regulation of mitotic sister chromatid segregation (GO:0033048)2.79871026
89telomere maintenance (GO:0000723)2.79354328
90response to peptidoglycan (GO:0032494)2.79345807
91germinal center formation (GO:0002467)2.79065195
92nonmotile primary cilium assembly (GO:0035058)2.78992050
93negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.78881072
94regulation of rhodopsin mediated signaling pathway (GO:0022400)2.78553187
95tRNA methylation (GO:0030488)2.77682344
96regulation of telomere maintenance (GO:0032204)2.77473258
97spindle assembly checkpoint (GO:0071173)2.76740800
98telomere organization (GO:0032200)2.76564504
99spliceosomal snRNP assembly (GO:0000387)2.76468981
100regulation of hippo signaling (GO:0035330)2.75611711
101serotonin metabolic process (GO:0042428)2.74414164
102indole-containing compound metabolic process (GO:0042430)2.74312118
103pseudouridine synthesis (GO:0001522)2.74276941
104maturation of 5.8S rRNA (GO:0000460)2.73770700
105positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.72860681
106membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.71688836
107regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.71681398
108mitotic spindle assembly checkpoint (GO:0007094)2.71402085
109epithelial cilium movement (GO:0003351)2.71019540
110negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.70124125
111negative regulation of chromosome segregation (GO:0051985)2.69738165
112regulation of mesoderm development (GO:2000380)2.69232933
113recombinational repair (GO:0000725)2.69049400
114spliceosomal complex assembly (GO:0000245)2.68738777
115transcription from RNA polymerase I promoter (GO:0006360)2.68219056
116rRNA processing (GO:0006364)2.68139423
117spindle checkpoint (GO:0031577)2.67998038
118rhodopsin mediated signaling pathway (GO:0016056)2.67663390
119double-strand break repair via homologous recombination (GO:0000724)2.67571549
120exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.67259044
121histone exchange (GO:0043486)2.66996502
122limb bud formation (GO:0060174)2.66827799
123anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.66327609
124deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.65704032
125nucleotide-excision repair, DNA gap filling (GO:0006297)2.65659828
126reflex (GO:0060004)2.63189578
127mitochondrial respiratory chain complex assembly (GO:0033108)2.63048337
128photoreceptor cell development (GO:0042461)2.62136436
129rRNA metabolic process (GO:0016072)2.61859438
130purine nucleobase biosynthetic process (GO:0009113)2.60425994
131otic vesicle formation (GO:0030916)2.60340062
132cellular response to ATP (GO:0071318)2.59977869
133histone mRNA metabolic process (GO:0008334)2.59883467
134nucleobase biosynthetic process (GO:0046112)2.59793126
135negative regulation of astrocyte differentiation (GO:0048712)2.59325461
136regulation of mitotic metaphase/anaphase transition (GO:0030071)2.59320459
137respiratory chain complex IV assembly (GO:0008535)2.59086640
138G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.59023632
139DNA damage response, detection of DNA damage (GO:0042769)2.58629194
140reciprocal meiotic recombination (GO:0007131)2.58385946
141reciprocal DNA recombination (GO:0035825)2.58385946
142startle response (GO:0001964)2.57804538
143modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.57655385
144positive regulation by organism of defense response of other organism involved in symbiotic interact2.57655385
145modulation by symbiont of host immune response (GO:0052553)2.57655385
146positive regulation by symbiont of host defense response (GO:0052509)2.57655385
147modulation by symbiont of host defense response (GO:0052031)2.57655385
148modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.57655385
149mitotic spindle checkpoint (GO:0071174)2.57436697
150embryonic epithelial tube formation (GO:0001838)2.57252200
151metaphase plate congression (GO:0051310)2.56521364
152spinal cord motor neuron differentiation (GO:0021522)2.56501033
153establishment of chromosome localization (GO:0051303)2.56477172
154pyrimidine nucleobase catabolic process (GO:0006208)2.56428367
155cAMP catabolic process (GO:0006198)2.55489396
156transmission of nerve impulse (GO:0019226)2.54560789
157protein-cofactor linkage (GO:0018065)2.53514522
158central nervous system myelination (GO:0022010)2.53267453
159axon ensheathment in central nervous system (GO:0032291)2.53267453
160transcription-coupled nucleotide-excision repair (GO:0006283)2.52855933
161cellular ketone body metabolic process (GO:0046950)2.52798416
162regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.52255821
163nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.50262036
164transcription elongation from RNA polymerase I promoter (GO:0006362)2.50222439
165RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.50219394
166cilium organization (GO:0044782)2.50026000
167regulation of mitotic sister chromatid separation (GO:0010965)2.49803240
168regulation of mitotic sister chromatid segregation (GO:0033047)2.49803240
169regulation of sister chromatid segregation (GO:0033045)2.49803240
170termination of RNA polymerase I transcription (GO:0006363)2.49755789
171cilium morphogenesis (GO:0060271)2.49135743
172nephron tubule morphogenesis (GO:0072078)2.49020411
173nephron epithelium morphogenesis (GO:0072088)2.49020411
174IMP biosynthetic process (GO:0006188)2.48485485
175DNA replication (GO:0006260)2.47828505
176head development (GO:0060322)2.46954178
177axoneme assembly (GO:0035082)2.46851773
178cornea development in camera-type eye (GO:0061303)2.46806406
179negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45541344
180behavioral response to ethanol (GO:0048149)2.45327971
181positive regulation of oligodendrocyte differentiation (GO:0048714)2.44971049
182centriole replication (GO:0007099)2.43944894
183negative regulation of synaptic transmission, GABAergic (GO:0032229)2.43654120
184translational termination (GO:0006415)2.43559674
185cilium assembly (GO:0042384)2.43386618
186viral transcription (GO:0019083)2.43219408
187signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.43039890
188eye photoreceptor cell development (GO:0042462)2.40237852
189neuron fate determination (GO:0048664)2.40113138
190epithelial tube formation (GO:0072175)2.39353655
191ketone body metabolic process (GO:1902224)2.38980010
192negative regulation of mast cell activation (GO:0033004)2.38317453
193retinal cone cell development (GO:0046549)2.35859298
194negative regulation of systemic arterial blood pressure (GO:0003085)2.35622070
195platelet dense granule organization (GO:0060155)2.35382594

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.15145211
2EZH2_22144423_ChIP-Seq_EOC_Human3.92342012
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.72416417
4ZNF274_21170338_ChIP-Seq_K562_Hela3.57325838
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53197172
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11629344
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.08541654
8GBX2_23144817_ChIP-Seq_PC3_Human3.03922701
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.01246153
10VDR_22108803_ChIP-Seq_LS180_Human2.98214339
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.82944400
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.77737186
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.71898360
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.71622593
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.71070769
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.64627182
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.60208232
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.58660146
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.57260406
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.56553401
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.53554257
22VDR_23849224_ChIP-Seq_CD4+_Human2.52554443
23IGF1R_20145208_ChIP-Seq_DFB_Human2.50547259
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48493976
25EWS_26573619_Chip-Seq_HEK293_Human2.47216954
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43254825
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.42102447
28FUS_26573619_Chip-Seq_HEK293_Human2.41012465
29TAF15_26573619_Chip-Seq_HEK293_Human2.32563408
30ELK1_19687146_ChIP-ChIP_HELA_Human2.31452965
31MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28729658
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.27880477
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.25246510
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21090529
35CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19321880
36NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14242952
37CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12414674
38CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06142984
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03184457
40TP63_19390658_ChIP-ChIP_HaCaT_Human2.02192430
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01911530
42P300_19829295_ChIP-Seq_ESCs_Human2.00522610
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98070939
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.95011411
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.93375629
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91707522
47FOXP3_21729870_ChIP-Seq_TREG_Human1.90465240
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.90426645
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.90224642
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.89503073
51XRN2_22483619_ChIP-Seq_HELA_Human1.87603115
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.85415041
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.84576206
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.82224510
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79205700
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78343764
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78105869
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76662340
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75193501
60ER_23166858_ChIP-Seq_MCF-7_Human1.74185298
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70571955
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.70304498
63CIITA_25753668_ChIP-Seq_RAJI_Human1.67942150
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67844933
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67754807
66IRF1_19129219_ChIP-ChIP_H3396_Human1.66921267
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66386757
68SPI1_23547873_ChIP-Seq_NB4_Human1.65974939
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65095131
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.64154225
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.61756929
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60597639
73STAT3_23295773_ChIP-Seq_U87_Human1.60219946
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.59842703
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59745321
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.59180416
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59045177
78TTF2_22483619_ChIP-Seq_HELA_Human1.58185153
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56262040
80MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.56156059
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55078203
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54261722
83SRF_21415370_ChIP-Seq_HL-1_Mouse1.53258065
84GABP_19822575_ChIP-Seq_HepG2_Human1.52672481
85SMAD4_21799915_ChIP-Seq_A2780_Human1.52188746
86KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52102888
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51080213
88CBP_20019798_ChIP-Seq_JUKART_Human1.51080213
89RNF2_27304074_Chip-Seq_NSC_Mouse1.50753236
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50108709
91MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49875270
92DCP1A_22483619_ChIP-Seq_HELA_Human1.47024434
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46326605
94BCAT_22108803_ChIP-Seq_LS180_Human1.44172710
95TCF4_23295773_ChIP-Seq_U87_Human1.42817102
96REST_21632747_ChIP-Seq_MESCs_Mouse1.41604924
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41548168
98AR_25329375_ChIP-Seq_VCAP_Human1.41218464
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40034212
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39642415
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39448200
102YY1_21170310_ChIP-Seq_MESCs_Mouse1.39200994
103ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37725142
104SMAD3_21741376_ChIP-Seq_EPCs_Human1.36730540
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36419549
106NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36391613
107STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35337693
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35308007
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35308007
110AR_21572438_ChIP-Seq_LNCaP_Human1.35293828
111FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.32479077
112TP53_22573176_ChIP-Seq_HFKS_Human1.31654765
113THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29107742
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28318454
115POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28081506
116JARID2_20064375_ChIP-Seq_MESCs_Mouse1.28061747
117PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27880700
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27087294
119PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24059896
120EZH2_27304074_Chip-Seq_ESCs_Mouse1.23740442
121ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23339174
122TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23117913
123POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22547605
124GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21274023
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.20208687
126MYB_21317192_ChIP-Seq_ERMYB_Mouse1.18757491
127SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18377864
128RUNX2_22187159_ChIP-Seq_PCA_Human1.17814317
129TCF4_22108803_ChIP-Seq_LS180_Human1.16586852
130STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16340183
131EED_16625203_ChIP-ChIP_MESCs_Mouse1.15831865
132BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15292736
133EZH2_27294783_Chip-Seq_NPCs_Mouse1.15259018
134NANOG_19829295_ChIP-Seq_ESCs_Human1.14738371
135SOX2_19829295_ChIP-Seq_ESCs_Human1.14738371
136KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14512013
137SALL1_21062744_ChIP-ChIP_HESCs_Human1.14317313
138STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.14283688
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14220469
140PRDM14_20953172_ChIP-Seq_ESCs_Human1.13984736
141MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13861979
142SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13561972
143NFE2_27457419_Chip-Seq_LIVER_Mouse1.13201167
144MYB_26560356_Chip-Seq_TH1_Human1.13116611
145ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12947371
146BP1_19119308_ChIP-ChIP_Hs578T_Human1.11906218
147SMAD4_21741376_ChIP-Seq_EPCs_Human1.11738215
148TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11244327
149NANOG_18555785_Chip-Seq_ESCs_Mouse1.10701439
150ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10476192
151MYB_26560356_Chip-Seq_TH2_Human1.08840851
152IRF8_27001747_Chip-Seq_BMDM_Mouse1.06640719
153KDM5A_27292631_Chip-Seq_BREAST_Human1.06632337
154AR_21909140_ChIP-Seq_LNCAP_Human1.06613250
155EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06281779
156PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06030106
157SCL_19346495_ChIP-Seq_HPC-7_Human1.03820057
158CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01760256
159P53_22387025_ChIP-Seq_ESCs_Mouse1.01470729
160EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01123319
161FOXA1_25329375_ChIP-Seq_VCAP_Human1.00855232
162FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00855232
163MYC_22102868_ChIP-Seq_BL_Human1.00805606
164TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00426939
165SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00243376
166TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99991680
167GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99234278
168SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99212149
169HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98774097
170ELK1_22589737_ChIP-Seq_MCF10A_Human0.97683445
171SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97478570
172NCOR_22424771_ChIP-Seq_293T_Human0.96804291
173JUN_21703547_ChIP-Seq_K562_Human0.96500981
174KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95933684
175KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95933684
176KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95933684
177STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95813037
178TP53_16413492_ChIP-PET_HCT116_Human0.95422634
179SOX2_21211035_ChIP-Seq_LN229_Gbm0.95410877
180TAL1_26923725_Chip-Seq_HPCs_Mouse0.95249195
181ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94828571
182RUNX1_22412390_ChIP-Seq_EML_Mouse0.93273942
183RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92524115
184E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91290665
185POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91103841
186MYC_18940864_ChIP-ChIP_HL60_Human0.90782714
187KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89759237
188RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87264004
189TFEB_21752829_ChIP-Seq_HELA_Human0.85859811
190SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85813942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.98474943
2MP0003111_abnormal_nucleus_morphology3.46436877
3MP0008057_abnormal_DNA_replication3.43525005
4MP0001835_abnormal_antigen_presentation3.20548543
5MP0010094_abnormal_chromosome_stability3.06372340
6MP0008058_abnormal_DNA_repair3.04018705
7MP0003077_abnormal_cell_cycle2.95278733
8MP0008007_abnormal_cellular_replicative2.67516893
9MP0002102_abnormal_ear_morphology2.66980917
10MP0004957_abnormal_blastocyst_morpholog2.58988325
11MP0004885_abnormal_endolymph2.47443095
12MP0005671_abnormal_response_to2.40072385
13MP0003646_muscle_fatigue2.33900508
14MP0003136_yellow_coat_color2.31523153
15MP0001853_heart_inflammation2.30919568
16MP0006292_abnormal_olfactory_placode2.21343110
17MP0002396_abnormal_hematopoietic_system2.20049373
18MP0004142_abnormal_muscle_tone2.13716343
19MP0006072_abnormal_retinal_apoptosis2.13627387
20MP0005551_abnormal_eye_electrophysiolog2.10478020
21MP0002277_abnormal_respiratory_mucosa2.10080709
22MP0005646_abnormal_pituitary_gland2.06080243
23MP0009785_altered_susceptibility_to2.03397451
24MP0003195_calcinosis2.03090016
25MP0003763_abnormal_thymus_physiology2.01815125
26MP0001968_abnormal_touch/_nociception2.00194129
27MP0003436_decreased_susceptibility_to2.00128132
28MP0009046_muscle_twitch1.99836415
29MP0001800_abnormal_humoral_immune1.98225104
30MP0010352_gastrointestinal_tract_polyps1.96973382
31MP0003880_abnormal_central_pattern1.96062584
32MP0002452_abnormal_antigen_presenting1.95312094
33MP0002638_abnormal_pupillary_reflex1.94811223
34MP0005000_abnormal_immune_tolerance1.92753789
35MP0002148_abnormal_hypersensitivity_rea1.92541253
36MP0000631_abnormal_neuroendocrine_gland1.92357359
37MP0003787_abnormal_imprinting1.90911046
38MP0002837_dystrophic_cardiac_calcinosis1.90792002
39MP0001485_abnormal_pinna_reflex1.89628535
40MP0009745_abnormal_behavioral_response1.87700458
41MP0005025_abnormal_response_to1.82287530
42MP0002234_abnormal_pharynx_morphology1.82038561
43MP0003941_abnormal_skin_development1.81981785
44MP0001819_abnormal_immune_cell1.78570262
45MP0008932_abnormal_embryonic_tissue1.77769385
46MP0002419_abnormal_innate_immunity1.77755034
47MP0002420_abnormal_adaptive_immunity1.77385511
48MP0002723_abnormal_immune_serum1.77063683
49MP0004808_abnormal_hematopoietic_stem1.74096162
50MP0000490_abnormal_crypts_of1.73757569
51MP0002398_abnormal_bone_marrow1.72765989
52MP0003315_abnormal_perineum_morphology1.72221410
53MP0002132_abnormal_respiratory_system1.70093885
54MP0002272_abnormal_nervous_system1.69372341
55MP0010307_abnormal_tumor_latency1.66508217
56MP0005645_abnormal_hypothalamus_physiol1.64310587
57MP0008872_abnormal_physiological_respon1.63686091
58MP0002653_abnormal_ependyma_morphology1.63093165
59MP0002938_white_spotting1.63057865
60MP0003448_altered_tumor_morphology1.60018726
61MP0005253_abnormal_eye_physiology1.57777006
62MP0002722_abnormal_immune_system1.55922162
63MP0004133_heterotaxia1.55535670
64MP0004043_abnormal_pH_regulation1.55504738
65MP0000689_abnormal_spleen_morphology1.55447728
66MP0004145_abnormal_muscle_electrophysio1.54698614
67MP0000716_abnormal_immune_system1.52071172
68MP0003890_abnormal_embryonic-extraembry1.51967958
69MP0002006_tumorigenesis1.51416071
70MP0003786_premature_aging1.46836596
71MP0002736_abnormal_nociception_after1.46731149
72MP0000427_abnormal_hair_cycle1.46352285
73MP0000703_abnormal_thymus_morphology1.46243853
74MP0000778_abnormal_nervous_system1.44769968
75MP0002405_respiratory_system_inflammati1.42717850
76MP0009333_abnormal_splenocyte_physiolog1.42223829
77MP0002064_seizures1.39092937
78MP0002876_abnormal_thyroid_physiology1.36430902
79MP0003186_abnormal_redox_activity1.36265621
80MP0001486_abnormal_startle_reflex1.36032773
81MP0004147_increased_porphyrin_level1.34897456
82MP0002429_abnormal_blood_cell1.33947816
83MP0010155_abnormal_intestine_physiology1.32440853
84MP0009764_decreased_sensitivity_to1.32252086
85MP0000685_abnormal_immune_system1.31466971
86MP0000858_altered_metastatic_potential1.29123300
87MP0006276_abnormal_autonomic_nervous1.28623464
88MP0002019_abnormal_tumor_incidence1.28525794
89MP0005464_abnormal_platelet_physiology1.28479577
90MP0001790_abnormal_immune_system1.28386253
91MP0005387_immune_system_phenotype1.28386253
92MP0002735_abnormal_chemical_nociception1.26921918
93MP0002572_abnormal_emotion/affect_behav1.26764629
94MP0000049_abnormal_middle_ear1.24842848
95MP0004742_abnormal_vestibular_system1.24492423
96MP0003937_abnormal_limbs/digits/tail_de1.24065760
97MP0008995_early_reproductive_senescence1.21655180
98MP0005174_abnormal_tail_pigmentation1.21205870
99MP0003283_abnormal_digestive_organ1.20990361
100MP0000350_abnormal_cell_proliferation1.20305709
101MP0003635_abnormal_synaptic_transmissio1.20041781
102MP0003567_abnormal_fetal_cardiomyocyte1.19910331
103MP0001873_stomach_inflammation1.18902775
104MP0002557_abnormal_social/conspecific_i1.17004929
105MP0001501_abnormal_sleep_pattern1.15731886
106MP0000313_abnormal_cell_death1.15532152
107MP0002928_abnormal_bile_duct1.15053286
108MP0002063_abnormal_learning/memory/cond1.12408514
109MP0005397_hematopoietic_system_phenotyp1.12338899
110MP0001545_abnormal_hematopoietic_system1.12338899
111MP0003724_increased_susceptibility_to1.12248410
112MP0002067_abnormal_sensory_capabilities1.10955010
113MP0001984_abnormal_olfaction1.10581807
114MP0001986_abnormal_taste_sensitivity1.10440166
115MP0001845_abnormal_inflammatory_respons1.10392232
116MP0003718_maternal_effect1.10065918
117MP0005195_abnormal_posterior_eye1.09754177
118MP0005389_reproductive_system_phenotype1.06988656
119MP0001293_anophthalmia1.06115099
120MP0003119_abnormal_digestive_system1.05624720
121MP0005386_behavior/neurological_phenoty1.05385599
122MP0004924_abnormal_behavior1.05385599
123MP0000465_gastrointestinal_hemorrhage1.04286210
124MP0004130_abnormal_muscle_cell1.03364588
125MP0001970_abnormal_pain_threshold1.03131733
126MP0002095_abnormal_skin_pigmentation1.03104806
127MP0002733_abnormal_thermal_nociception1.03095989
128MP0005310_abnormal_salivary_gland1.02553674
129MP0003121_genomic_imprinting1.02121435
130MP0002184_abnormal_innervation1.01575767
131MP0000026_abnormal_inner_ear1.00919448
132MP0005367_renal/urinary_system_phenotyp1.00841776
133MP0000516_abnormal_urinary_system1.00841776
134MP0000015_abnormal_ear_pigmentation0.99449668
135MP0008877_abnormal_DNA_methylation0.99179485
136MP0002752_abnormal_somatic_nervous0.97801110
137MP0002138_abnormal_hepatobiliary_system0.97563803
138MP0005075_abnormal_melanosome_morpholog0.96104881
139MP0004782_abnormal_surfactant_physiolog0.94359715
140MP0002166_altered_tumor_susceptibility0.94082282
141MP0002163_abnormal_gland_morphology0.93530613
142MP0002734_abnormal_mechanical_nocicepti0.92844069
143MP0001119_abnormal_female_reproductive0.91533941
144MP0002160_abnormal_reproductive_system0.91195480
145MP0002751_abnormal_autonomic_nervous0.90843922
146MP0001919_abnormal_reproductive_system0.90321285
147MP0000566_synostosis0.88816317
148MP0000627_abnormal_mammary_gland0.87702351
149MP0000955_abnormal_spinal_cord0.86954286
150MP0004215_abnormal_myocardial_fiber0.86853443
151MP0004947_skin_inflammation0.86499157
152MP0003938_abnormal_ear_development0.86193265
153MP0001440_abnormal_grooming_behavior0.85685320
154MP0005084_abnormal_gallbladder_morpholo0.84710137
155MP0008875_abnormal_xenobiotic_pharmacok0.82441360
156MP0000371_diluted_coat_color0.82294398
157MP0001963_abnormal_hearing_physiology0.81719026
158MP0005391_vision/eye_phenotype0.81393843
159MP0005423_abnormal_somatic_nervous0.80409789
160MP0001324_abnormal_eye_pigmentation0.80207330
161MP0001730_embryonic_growth_arrest0.79951150
162MP0000383_abnormal_hair_follicle0.78243555
163MP0010386_abnormal_urinary_bladder0.77957996
164MP0001529_abnormal_vocalization0.76165071
165MP0000569_abnormal_digit_pigmentation0.75806108
166MP0005379_endocrine/exocrine_gland_phen0.75513930
167MP0002882_abnormal_neuron_morphology0.75225086
168MP0001502_abnormal_circadian_rhythm0.74030751
169MP0008469_abnormal_protein_level0.73868629
170MP0008775_abnormal_heart_ventricle0.73472724
171MP0001533_abnormal_skeleton_physiology0.73469928
172MP0006082_CNS_inflammation0.71684537
173MP0001672_abnormal_embryogenesis/_devel0.71122417
174MP0005380_embryogenesis_phenotype0.71122417
175MP0001188_hyperpigmentation0.70772243
176MP0000613_abnormal_salivary_gland0.69801964
177MP0002210_abnormal_sex_determination0.69770195
178MP0005621_abnormal_cell_physiology0.68798726
179MP0002086_abnormal_extraembryonic_tissu0.66185871
180MP0008789_abnormal_olfactory_epithelium0.66173678
181MP0004381_abnormal_hair_follicle0.66147915
182MP0000372_irregular_coat_pigmentation0.64956194
183MP0003866_abnormal_defecation0.64865311
184MP0002098_abnormal_vibrissa_morphology0.64855627

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.46321798
2Birth length less than 3rd percentile (HP:0003561)4.44029903
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.34391130
4Chromsome breakage (HP:0040012)4.24490346
5Pancreatic fibrosis (HP:0100732)4.12248171
6True hermaphroditism (HP:0010459)4.00585863
7Granulocytopenia (HP:0001913)3.95380996
8Abnormality of midbrain morphology (HP:0002418)3.77796547
9Molar tooth sign on MRI (HP:0002419)3.77796547
10Congenital stationary night blindness (HP:0007642)3.68187272
11Nephronophthisis (HP:0000090)3.62189341
12Breast hypoplasia (HP:0003187)3.51640528
13Abnormality of the renal cortex (HP:0011035)3.20094825
14Abnormality of chromosome stability (HP:0003220)3.19276267
15Meckel diverticulum (HP:0002245)3.16747111
16Abnormality of the renal medulla (HP:0100957)3.16687798
17Abnormality of the preputium (HP:0100587)3.05351981
18Prostate neoplasm (HP:0100787)3.04575335
19Hyperventilation (HP:0002883)3.00601620
20Reticulocytopenia (HP:0001896)2.95519097
21Abnormality of the ileum (HP:0001549)2.95143621
22Type 2 muscle fiber atrophy (HP:0003554)2.90785998
23Progressive cerebellar ataxia (HP:0002073)2.90111302
24Progressive external ophthalmoplegia (HP:0000590)2.87791682
25Genetic anticipation (HP:0003743)2.83754453
26Recurrent abscess formation (HP:0002722)2.81563109
27Oral leukoplakia (HP:0002745)2.78141353
28Clubbing of toes (HP:0100760)2.76641562
29IgM deficiency (HP:0002850)2.76042631
30Muscle fiber atrophy (HP:0100295)2.74389611
31Chronic hepatic failure (HP:0100626)2.69295946
32Cystic liver disease (HP:0006706)2.69049743
33Eosinophilia (HP:0001880)2.68111884
34Carpal bone hypoplasia (HP:0001498)2.67181212
35Aplastic anemia (HP:0001915)2.65836446
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.64945525
37Bone marrow hypocellularity (HP:0005528)2.64174999
38Abnormality of alanine metabolism (HP:0010916)2.62334847
39Hyperalaninemia (HP:0003348)2.62334847
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.62334847
41Pustule (HP:0200039)2.61806429
42Abolished electroretinogram (ERG) (HP:0000550)2.57753843
43Attenuation of retinal blood vessels (HP:0007843)2.55572173
44Premature graying of hair (HP:0002216)2.54771383
45Stomach cancer (HP:0012126)2.53435692
46Retrobulbar optic neuritis (HP:0100654)2.49040588
47Optic neuritis (HP:0100653)2.49040588
48Renal cortical cysts (HP:0000803)2.48569655
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.48166379
50Pendular nystagmus (HP:0012043)2.46509935
51Medulloblastoma (HP:0002885)2.46460309
52Abnormality of eosinophils (HP:0001879)2.46062732
53Myelodysplasia (HP:0002863)2.45548960
54Mediastinal lymphadenopathy (HP:0100721)2.44443174
55Medial flaring of the eyebrow (HP:0010747)2.43591811
56Eczematoid dermatitis (HP:0000976)2.43251065
57Agnosia (HP:0010524)2.40085242
58Gaze-evoked nystagmus (HP:0000640)2.40052406
59Furrowed tongue (HP:0000221)2.39745245
60Lymphoma (HP:0002665)2.39361799
61Tubular atrophy (HP:0000092)2.37671607
62Petechiae (HP:0000967)2.36608495
63Sclerocornea (HP:0000647)2.36287044
64Leukocytosis (HP:0001974)2.36080803
65Abnormality of the prostate (HP:0008775)2.35063186
66IgG deficiency (HP:0004315)2.31952700
67Type II lissencephaly (HP:0007260)2.31286122
68Rough bone trabeculation (HP:0100670)2.30213499
69Patellar aplasia (HP:0006443)2.29851152
70Recurrent bacterial skin infections (HP:0005406)2.29547039
71Abnormality of macrophages (HP:0004311)2.27890465
72Obstructive lung disease (HP:0006536)2.26988654
73Chronic obstructive pulmonary disease (HP:0006510)2.26988654
74Abnormal number of erythroid precursors (HP:0012131)2.23422488
75Ectopic kidney (HP:0000086)2.23219248
76Myositis (HP:0100614)2.22481665
77Abnormal rod and cone electroretinograms (HP:0008323)2.21717163
78Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21660897
79Congenital, generalized hypertrichosis (HP:0004540)2.20579999
80Acute lymphatic leukemia (HP:0006721)2.20414895
81Optic nerve hypoplasia (HP:0000609)2.18987805
82Broad-based gait (HP:0002136)2.18972612
83Abnormality of cells of the erythroid lineage (HP:0012130)2.18965074
84T lymphocytopenia (HP:0005403)2.18691180
85Aplasia/Hypoplasia of the patella (HP:0006498)2.18268161
86Duodenal stenosis (HP:0100867)2.18050691
87Small intestinal stenosis (HP:0012848)2.18050691
88Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.16860125
89Recurrent fungal infections (HP:0002841)2.16366216
90Aplasia/Hypoplasia of the tongue (HP:0010295)2.15561597
91Thrombocytosis (HP:0001894)2.14298277
92Febrile seizures (HP:0002373)2.12998403
93Pallor (HP:0000980)2.12859003
94Anencephaly (HP:0002323)2.12708226
95Abnormality of the anterior horn cell (HP:0006802)2.12312012
96Degeneration of anterior horn cells (HP:0002398)2.12312012
97Protruding tongue (HP:0010808)2.12193598
98Inability to walk (HP:0002540)2.11542126
99Colon cancer (HP:0003003)2.11537501
100Abnormality of the renal collecting system (HP:0004742)2.11191962
101Polydipsia (HP:0001959)2.09616587
102Abnormal drinking behavior (HP:0030082)2.09616587
103Fair hair (HP:0002286)2.09427419
104Chronic mucocutaneous candidiasis (HP:0002728)2.09219865
105Recurrent cutaneous fungal infections (HP:0011370)2.09219865
106Orchitis (HP:0100796)2.08852112
107Abnormality of T cell number (HP:0011839)2.08462606
108Gait imbalance (HP:0002141)2.08184758
109Cleft eyelid (HP:0000625)2.06887293
110Duplicated collecting system (HP:0000081)2.05826365
111Encephalitis (HP:0002383)2.05565176
112Amaurosis fugax (HP:0100576)2.05316718
113Congenital hepatic fibrosis (HP:0002612)2.05051024
114Progressive inability to walk (HP:0002505)2.04350270
115Leukopenia (HP:0001882)2.04046441
116Decreased central vision (HP:0007663)2.03678759
117Abnormality of T cells (HP:0002843)2.03600016
118Bile duct proliferation (HP:0001408)2.01503644
119Abnormal biliary tract physiology (HP:0012439)2.01503644
120Absent thumb (HP:0009777)2.01463349
121Septo-optic dysplasia (HP:0100842)2.00821364
122Tracheoesophageal fistula (HP:0002575)2.00283576
123Male pseudohermaphroditism (HP:0000037)1.99960421
124Abnormality of the carotid arteries (HP:0005344)1.99245316
125Cheilitis (HP:0100825)1.98855299
126Prolonged bleeding time (HP:0003010)1.98544545
127Rhabdomyosarcoma (HP:0002859)1.97697294
128Keratoconus (HP:0000563)1.96968504
129Increased corneal curvature (HP:0100692)1.96968504
130Congenital primary aphakia (HP:0007707)1.96093183
131Chorioretinal atrophy (HP:0000533)1.95835490
132Elevated erythrocyte sedimentation rate (HP:0003565)1.95539932
133Postaxial foot polydactyly (HP:0001830)1.93514166
134Aplasia/Hypoplasia involving the musculature (HP:0001460)1.93365936
135Abnormal delayed hypersensitivity skin test (HP:0002963)1.93047264
136Poor head control (HP:0002421)1.93001581
137Meningitis (HP:0001287)1.92574360
138Intestinal atresia (HP:0011100)1.92419506
139Severe combined immunodeficiency (HP:0004430)1.92083747
140Recurrent viral infections (HP:0004429)1.90615083
141Neoplasm of the adrenal cortex (HP:0100641)1.89894516
142Basal ganglia calcification (HP:0002135)1.89564382
143Short tibia (HP:0005736)1.89546296
144Microretrognathia (HP:0000308)1.88632160
145Lissencephaly (HP:0001339)1.88438578
146Genital tract atresia (HP:0001827)1.87866131
147Abnormality of DNA repair (HP:0003254)1.87736829
148Cellular immunodeficiency (HP:0005374)1.87296834
149Drooling (HP:0002307)1.86732987
150Optic nerve coloboma (HP:0000588)1.85705334
151Nephrogenic diabetes insipidus (HP:0009806)1.85368164
152Aseptic necrosis (HP:0010885)1.85092072
153Abnormal spermatogenesis (HP:0008669)1.84932691
154Lymphopenia (HP:0001888)1.84451373
155Horseshoe kidney (HP:0000085)1.84379627
156Vacuolated lymphocytes (HP:0001922)1.83534260
157Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82987120
158Abnormality of cells of the lymphoid lineage (HP:0012140)1.82675314
159Vaginal atresia (HP:0000148)1.82300063
160Large for gestational age (HP:0001520)1.81078003
161Thyroid-stimulating hormone excess (HP:0002925)1.80645867
162Type I transferrin isoform profile (HP:0003642)1.80187381
163Triphalangeal thumb (HP:0001199)1.80160012
164Combined immunodeficiency (HP:0005387)1.79828413
165Abnormality of T cell physiology (HP:0011840)1.78768593
166Abnormality of the labia minora (HP:0012880)1.77975263
167Concave nail (HP:0001598)1.74270536
168Bony spicule pigmentary retinopathy (HP:0007737)1.73794568
169Thyroiditis (HP:0100646)1.72823714
170Pachygyria (HP:0001302)1.71081633
171Absent/shortened dynein arms (HP:0200106)1.71051212
172Dynein arm defect of respiratory motile cilia (HP:0012255)1.71051212
173Aplasia/Hypoplasia of the spleen (HP:0010451)1.70824325
174Abnormality of the pons (HP:0007361)1.69645212
175Atonic seizures (HP:0010819)1.69643363
176Oligodactyly (hands) (HP:0001180)1.69227108
177Hemiparesis (HP:0001269)1.69223624
178Hypoplastic iliac wings (HP:0002866)1.68806004
179Hypoplasia of the pons (HP:0012110)1.68646784
180Preaxial hand polydactyly (HP:0001177)1.68466677
181Partial agenesis of the corpus callosum (HP:0001338)1.68128922
182Gastrointestinal atresia (HP:0002589)1.67151992
183Anophthalmia (HP:0000528)1.66617536
184Small hand (HP:0200055)1.65258561

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.39226580
2FRK5.26190749
3STK164.93820911
4PLK44.38726114
5ZAK3.45829851
6IRAK43.18660683
7BUB13.13637542
8BMPR1B3.11156924
9SRPK12.67518401
10ADRBK22.67058622
11WNK42.58133568
12WEE12.46978335
13TAOK32.38492618
14EIF2AK12.30468996
15CASK2.29734764
16TXK2.28618318
17WNK32.28252920
18MARK12.07792831
19IRAK22.04977682
20MAPK131.92312592
21STK391.91709617
22MAP4K21.80238434
23IRAK11.80087006
24TNIK1.78889594
25INSRR1.77620064
26NME21.70224774
27MAP3K141.61733083
28EPHA21.59607124
29MAP4K11.59283926
30MAP3K41.56750869
31TSSK61.53122870
32OXSR11.47571606
33DYRK31.42895036
34CAMKK21.42283240
35TTK1.40918665
36PLK11.37263319
37EIF2AK31.37238235
38EIF2AK21.36217758
39ATR1.34228260
40EPHA41.31067519
41VRK11.25550970
42CDC71.24482261
43PLK31.23100053
44TEC1.22556009
45DAPK21.18142703
46IKBKB1.15877115
47NEK21.15604026
48NTRK21.12817416
49MKNK11.11342784
50ADRBK11.07544096
51JAK31.04780203
52NEK91.03232528
53TIE11.03017532
54PIK3CA1.01728328
55PLK21.01199046
56BTK1.00765569
57DYRK21.00552987
58BRSK21.00020839
59AURKB0.99308913
60PAK30.99265432
61PIM20.95955238
62PIM10.95915681
63MKNK20.95803736
64RPS6KB20.95583407
65MAPK150.94239245
66KDR0.93811849
67TRIM280.93371251
68PBK0.93268613
69PRKCG0.92853014
70GRK10.89599824
71MST40.88034563
72STK40.87827328
73IKBKE0.85463030
74PRKCE0.84788739
75MAP2K70.82941219
76RPS6KA40.82864407
77BLK0.81271275
78TESK20.80198895
79BCR0.79983735
80TAF10.79510979
81TLK10.78795981
82FGFR20.78721960
83KIT0.77810686
84NTRK30.77338958
85PINK10.74034298
86CSNK1G20.72813850
87CDK120.72323457
88CHUK0.72162176
89NLK0.71477869
90CDK70.68860892
91CSNK1G10.68686706
92TYK20.68569115
93MAP3K80.67808092
94TNK20.67119728
95STK110.67100798
96BCKDK0.66883447
97PKN10.66650577
98LATS10.66218157
99ACVR1B0.65867403
100CCNB10.64269729
101NEK60.64057497
102STK30.62966324
103NUAK10.62196967
104BRD40.61264223
105MAPKAPK50.60480658
106PAK40.60272127
107STK240.58829753
108OBSCN0.58258095
109CSNK1G30.57823848
110STK38L0.57437157
111ABL20.57382713
112CAMK10.55292310
113CSNK1A1L0.55255200
114SGK20.54341055
115ATM0.54259818
116ALK0.53541998
117CHEK10.52903379
118PRKCQ0.52764522
119CHEK20.51521485
120CAMK2A0.50606453
121SYK0.50552642
122STK100.50093327
123LYN0.49917406
124CAMK1G0.49122369
125CDK190.48353869
126NEK10.47694316
127PHKG20.47418654
128PHKG10.47418654
129CSNK1A10.46398588
130NME10.46017798
131ERBB20.44894486
132PASK0.44824555
133CDK80.44615174
134GRK70.44470475
135CSNK2A10.44456264
136MAP2K60.44445638
137PRKACA0.44038273
138MUSK0.43639756
139ERBB30.43038754
140CSNK1D0.42760931
141CAMK1D0.42391984
142CDK30.42174303
143ZAP700.41589712
144WNK10.40814318
145BRSK10.40274388
146AURKA0.39247458
147HCK0.39218562
148TBK10.39129863
149PTK2B0.37797509
150CDK20.37631897
151EPHA30.37608221
152PRKCI0.37056131
153CAMK40.35458565
154YES10.35377069
155CAMKK10.34932326
156RPS6KA60.34891782
157AKT30.34847775
158LCK0.34682287
159TGFBR10.34535786
160SCYL20.34322244
161FGFR30.34303429
162PRKAA10.33772486
163DYRK1A0.32924602
164TYRO30.32371762
165CDK40.32340461
166RPS6KA50.31594361
167PNCK0.31032895
168JAK10.30689005

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.99510657
2RNA polymerase_Homo sapiens_hsa030203.14438223
3Mismatch repair_Homo sapiens_hsa034303.11243395
4Proteasome_Homo sapiens_hsa030503.06728564
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.95483182
6Ribosome_Homo sapiens_hsa030102.89606615
7Nicotine addiction_Homo sapiens_hsa050332.71395677
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.52823936
9Fanconi anemia pathway_Homo sapiens_hsa034602.48677393
10Nitrogen metabolism_Homo sapiens_hsa009102.45921946
11Pyrimidine metabolism_Homo sapiens_hsa002402.39292277
12Spliceosome_Homo sapiens_hsa030402.36524505
13Linoleic acid metabolism_Homo sapiens_hsa005912.29413317
14Base excision repair_Homo sapiens_hsa034102.24417036
15Homologous recombination_Homo sapiens_hsa034402.23748498
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.14703520
17Nucleotide excision repair_Homo sapiens_hsa034202.14447190
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.05591940
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.05456772
20RNA transport_Homo sapiens_hsa030132.04529264
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.99024391
22One carbon pool by folate_Homo sapiens_hsa006701.94720316
23Cell cycle_Homo sapiens_hsa041101.92512578
24Butanoate metabolism_Homo sapiens_hsa006501.90192950
25Selenocompound metabolism_Homo sapiens_hsa004501.86182985
26Non-homologous end-joining_Homo sapiens_hsa034501.83560258
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.82572921
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.81106900
29Oxidative phosphorylation_Homo sapiens_hsa001901.80192631
30RNA degradation_Homo sapiens_hsa030181.76379241
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76251930
32p53 signaling pathway_Homo sapiens_hsa041151.75759231
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.70751457
34Primary immunodeficiency_Homo sapiens_hsa053401.67780542
35Morphine addiction_Homo sapiens_hsa050321.67014419
36Caffeine metabolism_Homo sapiens_hsa002321.64620746
37Protein export_Homo sapiens_hsa030601.62729672
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.60752971
39Tryptophan metabolism_Homo sapiens_hsa003801.54251967
40Basal transcription factors_Homo sapiens_hsa030221.49722947
41Taste transduction_Homo sapiens_hsa047421.47902878
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47401837
43Antigen processing and presentation_Homo sapiens_hsa046121.46350724
44Measles_Homo sapiens_hsa051621.45642413
45Graft-versus-host disease_Homo sapiens_hsa053321.45092270
46Ether lipid metabolism_Homo sapiens_hsa005651.44692940
47Parkinsons disease_Homo sapiens_hsa050121.44526893
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40875416
49Epstein-Barr virus infection_Homo sapiens_hsa051691.38660246
50Herpes simplex infection_Homo sapiens_hsa051681.34594830
51Olfactory transduction_Homo sapiens_hsa047401.33604381
52Leishmaniasis_Homo sapiens_hsa051401.32442469
53Circadian entrainment_Homo sapiens_hsa047131.32068182
54Glutamatergic synapse_Homo sapiens_hsa047241.30965744
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28045358
56Purine metabolism_Homo sapiens_hsa002301.27387091
57Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26893531
58GABAergic synapse_Homo sapiens_hsa047271.26350745
59Allograft rejection_Homo sapiens_hsa053301.21342632
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20363621
61Hematopoietic cell lineage_Homo sapiens_hsa046401.19916498
62Intestinal immune network for IgA production_Homo sapiens_hsa046721.19785857
63Primary bile acid biosynthesis_Homo sapiens_hsa001201.19325311
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17094966
65Legionellosis_Homo sapiens_hsa051341.16570001
66Steroid hormone biosynthesis_Homo sapiens_hsa001401.15984928
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15867375
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14783342
69Cardiac muscle contraction_Homo sapiens_hsa042601.11523917
70Serotonergic synapse_Homo sapiens_hsa047261.10748570
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10575108
72ABC transporters_Homo sapiens_hsa020101.09194746
73Systemic lupus erythematosus_Homo sapiens_hsa053221.08802807
74Insulin secretion_Homo sapiens_hsa049111.05274097
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00725802
76mRNA surveillance pathway_Homo sapiens_hsa030150.99058622
77Huntingtons disease_Homo sapiens_hsa050160.96472347
78Apoptosis_Homo sapiens_hsa042100.95160941
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94054255
80Propanoate metabolism_Homo sapiens_hsa006400.92229321
81Asthma_Homo sapiens_hsa053100.90690984
82Alzheimers disease_Homo sapiens_hsa050100.89924960
83Chemical carcinogenesis_Homo sapiens_hsa052040.88962685
84Calcium signaling pathway_Homo sapiens_hsa040200.84951071
85Influenza A_Homo sapiens_hsa051640.83670219
86Viral carcinogenesis_Homo sapiens_hsa052030.82669262
87Peroxisome_Homo sapiens_hsa041460.82541374
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82108208
89Retinol metabolism_Homo sapiens_hsa008300.81557113
90HTLV-I infection_Homo sapiens_hsa051660.81287490
91Hedgehog signaling pathway_Homo sapiens_hsa043400.81276314
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79928476
93Dopaminergic synapse_Homo sapiens_hsa047280.76842014
94Basal cell carcinoma_Homo sapiens_hsa052170.76332634
95Autoimmune thyroid disease_Homo sapiens_hsa053200.75669417
96Salivary secretion_Homo sapiens_hsa049700.75269245
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75215373
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74135144
99Osteoclast differentiation_Homo sapiens_hsa043800.73034385
100Glycerolipid metabolism_Homo sapiens_hsa005610.72225453
101Sulfur metabolism_Homo sapiens_hsa009200.70374155
102Cholinergic synapse_Homo sapiens_hsa047250.70169194
103Tuberculosis_Homo sapiens_hsa051520.69928860
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69886019
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.66940978
106Ovarian steroidogenesis_Homo sapiens_hsa049130.66656236
107Other glycan degradation_Homo sapiens_hsa005110.66232202
108Shigellosis_Homo sapiens_hsa051310.66127611
109Amphetamine addiction_Homo sapiens_hsa050310.65292437
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64773013
111Hepatitis B_Homo sapiens_hsa051610.63642893
112Malaria_Homo sapiens_hsa051440.62644495
113Dorso-ventral axis formation_Homo sapiens_hsa043200.62514884
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62363765
115Cocaine addiction_Homo sapiens_hsa050300.61012415
116TNF signaling pathway_Homo sapiens_hsa046680.60730053
117Toxoplasmosis_Homo sapiens_hsa051450.59903064
118Pertussis_Homo sapiens_hsa051330.59441535
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59370627
120Phototransduction_Homo sapiens_hsa047440.58021769
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57900833
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56858833
123Sulfur relay system_Homo sapiens_hsa041220.56798340
124Small cell lung cancer_Homo sapiens_hsa052220.56730969
125cAMP signaling pathway_Homo sapiens_hsa040240.54022097
126beta-Alanine metabolism_Homo sapiens_hsa004100.53399453
127Long-term depression_Homo sapiens_hsa047300.53260763
128T cell receptor signaling pathway_Homo sapiens_hsa046600.53186837
129B cell receptor signaling pathway_Homo sapiens_hsa046620.53048576
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50177375
131Histidine metabolism_Homo sapiens_hsa003400.49546007
132Type I diabetes mellitus_Homo sapiens_hsa049400.49474604
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48757587
134Rheumatoid arthritis_Homo sapiens_hsa053230.47716164
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46896269
136Circadian rhythm_Homo sapiens_hsa047100.46646349
137Alcoholism_Homo sapiens_hsa050340.46577213
138Oxytocin signaling pathway_Homo sapiens_hsa049210.45484794
139Acute myeloid leukemia_Homo sapiens_hsa052210.44720425
140Renin secretion_Homo sapiens_hsa049240.44393998
141Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43557344
142Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43438761
143MicroRNAs in cancer_Homo sapiens_hsa052060.43035744
144Lysosome_Homo sapiens_hsa041420.42990765
145Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42241606
146Chemokine signaling pathway_Homo sapiens_hsa040620.42020190
147Salmonella infection_Homo sapiens_hsa051320.40688410
148Vitamin digestion and absorption_Homo sapiens_hsa049770.39847189
149Gastric acid secretion_Homo sapiens_hsa049710.39680630
150Oocyte meiosis_Homo sapiens_hsa041140.39643674
151Vascular smooth muscle contraction_Homo sapiens_hsa042700.39450761
152Viral myocarditis_Homo sapiens_hsa054160.39089948
153Pentose phosphate pathway_Homo sapiens_hsa000300.38770866
154Lysine degradation_Homo sapiens_hsa003100.38413726
155Fructose and mannose metabolism_Homo sapiens_hsa000510.37361314
156Metabolic pathways_Homo sapiens_hsa011000.37197476
157Fat digestion and absorption_Homo sapiens_hsa049750.37142177
158Axon guidance_Homo sapiens_hsa043600.36998470
159Hepatitis C_Homo sapiens_hsa051600.35703862
160FoxO signaling pathway_Homo sapiens_hsa040680.34678794
161Staphylococcus aureus infection_Homo sapiens_hsa051500.34059725
162Phagosome_Homo sapiens_hsa041450.33191523
163Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32706122
164Notch signaling pathway_Homo sapiens_hsa043300.32119339
165Chronic myeloid leukemia_Homo sapiens_hsa052200.32039264
166Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31984221
167Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31513432
168N-Glycan biosynthesis_Homo sapiens_hsa005100.30756383
169Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29627242
170Sphingolipid metabolism_Homo sapiens_hsa006000.29524441
171Arachidonic acid metabolism_Homo sapiens_hsa005900.29300809
172Regulation of autophagy_Homo sapiens_hsa041400.28910026
173Leukocyte transendothelial migration_Homo sapiens_hsa046700.28662622
174Colorectal cancer_Homo sapiens_hsa052100.28061615
175Folate biosynthesis_Homo sapiens_hsa007900.25916378

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