GPANK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located in a cluster of HLA-B-associated transcripts, which is included in the human major histocompatability complex III region. This gene encodes a protein which is thought to play a role in immunity. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.03365461
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.24175239
3ATP synthesis coupled proton transport (GO:0015986)5.24175239
4DNA deamination (GO:0045006)4.87443463
5ribosomal small subunit assembly (GO:0000028)4.61098727
6chaperone-mediated protein transport (GO:0072321)4.52721407
7DNA strand elongation involved in DNA replication (GO:0006271)4.44920350
8maturation of SSU-rRNA (GO:0030490)4.40386858
9respiratory electron transport chain (GO:0022904)4.32105829
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.28765097
11mitochondrial respiratory chain complex I assembly (GO:0032981)4.25161691
12NADH dehydrogenase complex assembly (GO:0010257)4.25161691
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.25161691
14telomere maintenance via semi-conservative replication (GO:0032201)4.24664024
15electron transport chain (GO:0022900)4.22297167
16DNA strand elongation (GO:0022616)4.21489724
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.19516556
18protein complex biogenesis (GO:0070271)4.18828814
19mitochondrial respiratory chain complex assembly (GO:0033108)4.13192726
20viral transcription (GO:0019083)4.03803273
21DNA replication initiation (GO:0006270)3.97740436
22formation of translation preinitiation complex (GO:0001731)3.97413758
23translational termination (GO:0006415)3.95670327
24regulation of mitochondrial translation (GO:0070129)3.87953343
25ribosomal small subunit biogenesis (GO:0042274)3.83840290
26pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.82137762
27DNA replication checkpoint (GO:0000076)3.79277510
28telomere maintenance via recombination (GO:0000722)3.77826486
29ribosome biogenesis (GO:0042254)3.69324880
30translational elongation (GO:0006414)3.68524791
31rRNA methylation (GO:0031167)3.67604120
32purine nucleobase biosynthetic process (GO:0009113)3.67200029
33ribonucleoprotein complex biogenesis (GO:0022613)3.65268603
34nucleobase biosynthetic process (GO:0046112)3.64891384
35translational initiation (GO:0006413)3.52904520
36ribosomal large subunit biogenesis (GO:0042273)3.52592896
37protein targeting to mitochondrion (GO:0006626)3.52139875
38deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.51989122
39mitotic recombination (GO:0006312)3.51783905
40mitotic metaphase plate congression (GO:0007080)3.45334794
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.44632196
42termination of RNA polymerase III transcription (GO:0006386)3.39655053
43transcription elongation from RNA polymerase III promoter (GO:0006385)3.39655053
44establishment of protein localization to mitochondrion (GO:0072655)3.39490964
45chromatin remodeling at centromere (GO:0031055)3.36955719
46CENP-A containing nucleosome assembly (GO:0034080)3.36396356
47cotranslational protein targeting to membrane (GO:0006613)3.34787564
48establishment of integrated proviral latency (GO:0075713)3.34259450
49protein targeting to ER (GO:0045047)3.33709036
50nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.29422968
51nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.29132479
52telomere maintenance via telomere lengthening (GO:0010833)3.28925209
53transcription-coupled nucleotide-excision repair (GO:0006283)3.27079315
54nucleotide-excision repair, DNA gap filling (GO:0006297)3.25687075
55folic acid metabolic process (GO:0046655)3.25182562
56protein localization to mitochondrion (GO:0070585)3.24445746
57rRNA processing (GO:0006364)3.23572697
58DNA unwinding involved in DNA replication (GO:0006268)3.20789881
59pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.20645915
60regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19493380
61exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.18844007
62establishment of protein localization to endoplasmic reticulum (GO:0072599)3.17835222
63protein localization to kinetochore (GO:0034501)3.17643286
64viral life cycle (GO:0019058)3.16953923
65pyrimidine nucleotide catabolic process (GO:0006244)3.16480970
66protein localization to endoplasmic reticulum (GO:0070972)3.15709630
67oxidative phosphorylation (GO:0006119)3.15319349
68rRNA metabolic process (GO:0016072)3.14766813
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14516957
70cellular protein complex disassembly (GO:0043624)3.13731759
71protein localization to chromosome, centromeric region (GO:0071459)3.11795051
72establishment of viral latency (GO:0019043)3.10196543
73base-excision repair, AP site formation (GO:0006285)3.09443365
74regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.09320900
75spliceosomal snRNP assembly (GO:0000387)3.09188149
76tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.08774032
77RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.08774032
78anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.07866925
79rRNA modification (GO:0000154)3.03008353
80protein neddylation (GO:0045116)3.02881715
81ribosome assembly (GO:0042255)3.02857764
82DNA replication-independent nucleosome organization (GO:0034724)3.02692638
83DNA replication-independent nucleosome assembly (GO:0006336)3.02692638
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00824101
85DNA catabolic process, exonucleolytic (GO:0000738)3.00757883
86maturation of 5.8S rRNA (GO:0000460)2.99507859
87histone exchange (GO:0043486)2.99225818
88translation (GO:0006412)2.98480433
89cytochrome complex assembly (GO:0017004)2.97510608
90aerobic respiration (GO:0009060)2.97201937
91regulation of double-strand break repair via homologous recombination (GO:0010569)2.96538766
92DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.96188477
937-methylguanosine mRNA capping (GO:0006370)2.95362823
94respiratory chain complex IV assembly (GO:0008535)2.94802323
95metaphase plate congression (GO:0051310)2.94323767
96signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.92617198
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.92617198
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.92617198
99intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.92478903
100signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.92478903
101proteasome assembly (GO:0043248)2.92078251
102ATP biosynthetic process (GO:0006754)2.91642784
103protein-cofactor linkage (GO:0018065)2.91105243
104RNA capping (GO:0036260)2.90827367
1057-methylguanosine RNA capping (GO:0009452)2.90827367
106signal transduction involved in DNA integrity checkpoint (GO:0072401)2.89098793
107signal transduction involved in DNA damage checkpoint (GO:0072422)2.89098793
108negative regulation of ligase activity (GO:0051352)2.86517219
109negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.86517219
110cellular component biogenesis (GO:0044085)2.85404183
111signal transduction involved in cell cycle checkpoint (GO:0072395)2.85038897
112protein complex disassembly (GO:0043241)2.85012910
113mitotic nuclear envelope disassembly (GO:0007077)2.84705588
114pseudouridine synthesis (GO:0001522)2.82067770
115DNA replication-dependent nucleosome organization (GO:0034723)2.81714297
116DNA replication-dependent nucleosome assembly (GO:0006335)2.81714297
117cell cycle G1/S phase transition (GO:0044843)2.80937767
118G1/S transition of mitotic cell cycle (GO:0000082)2.80937767
119mitochondrial transport (GO:0006839)2.78876262
120establishment of chromosome localization (GO:0051303)2.76943230
121purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.76869374
122nuclear-transcribed mRNA catabolic process (GO:0000956)2.76082508
123termination of RNA polymerase I transcription (GO:0006363)2.73797190
124somatic diversification of immune receptors via somatic mutation (GO:0002566)2.72883918
125somatic hypermutation of immunoglobulin genes (GO:0016446)2.72883918
126protein K6-linked ubiquitination (GO:0085020)2.72482420
127macromolecular complex disassembly (GO:0032984)2.71647325
128viral mRNA export from host cell nucleus (GO:0046784)2.70819405
129positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.70184696
130antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.69332985
131transcription from RNA polymerase I promoter (GO:0006360)2.66653887
132transcription elongation from RNA polymerase I promoter (GO:0006362)2.66597732
133folic acid-containing compound biosynthetic process (GO:0009396)2.66431003
134regulation of cellular amino acid metabolic process (GO:0006521)2.65967433
135IMP biosynthetic process (GO:0006188)2.64618086
136deoxyribonucleotide biosynthetic process (GO:0009263)2.63580901
137mRNA catabolic process (GO:0006402)2.62525078
138attachment of spindle microtubules to kinetochore (GO:0008608)2.61655348
139RNA catabolic process (GO:0006401)2.61541801

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.84589298
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.59049798
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.41659500
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.10142731
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.04313688
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.00286619
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.98377745
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.89561896
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.87421143
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.78721959
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.69541137
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.68752887
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65936538
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.48620651
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.47996833
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.47549267
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.41405597
18VDR_23849224_ChIP-Seq_CD4+_Human2.40155935
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.22249693
20XRN2_22483619_ChIP-Seq_HELA_Human2.21152586
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.19559863
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.14413574
23FOXP3_21729870_ChIP-Seq_TREG_Human2.12145168
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08000658
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06848212
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04862906
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00395802
28DCP1A_22483619_ChIP-Seq_HELA_Human1.94305192
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.94066124
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89168599
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.88463069
32CIITA_25753668_ChIP-Seq_RAJI_Human1.87931464
33GABP_19822575_ChIP-Seq_HepG2_Human1.87362701
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86960679
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82676314
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.80085466
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77204391
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73714994
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71596027
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.68702317
41TTF2_22483619_ChIP-Seq_HELA_Human1.67645259
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64166619
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.63260592
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63136786
45* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.62932193
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60894962
47MYC_22102868_ChIP-Seq_BL_Human1.59269313
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58980026
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57148885
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55227120
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52825250
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50676184
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.50149341
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48738607
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46774857
56* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42646968
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42535266
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38284108
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.38213323
60AR_21909140_ChIP-Seq_LNCAP_Human1.36631426
61KDM5A_27292631_Chip-Seq_BREAST_Human1.30947674
62SPI1_23547873_ChIP-Seq_NB4_Human1.30075540
63IRF8_22096565_ChIP-ChIP_GC-B_Human1.29136017
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28836112
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26809368
66VDR_21846776_ChIP-Seq_THP-1_Human1.25040986
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24885021
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23639857
69ELK1_19687146_ChIP-ChIP_HELA_Human1.21690342
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18638422
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18181336
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12975209
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08990513
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08874699
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07782143
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07668801
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06296096
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06208702
79ZNF263_19887448_ChIP-Seq_K562_Human1.06174575
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06022242
81IRF8_21731497_ChIP-ChIP_J774_Mouse1.05724886
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05542327
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04546168
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03704581
85FOXP1_21924763_ChIP-Seq_HESCs_Human1.02221742
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01786467
87CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01740049
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01124580
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01041105
90MYC_18940864_ChIP-ChIP_HL60_Human1.00778163
91YY1_22570637_ChIP-Seq_MALME-3M_Human1.00711696
92TFEB_21752829_ChIP-Seq_HELA_Human0.98141940
93EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97275377
94CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96580581
95MYB_26560356_Chip-Seq_TH1_Human0.95904530
96TP63_19390658_ChIP-ChIP_HaCaT_Human0.95111868
97SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.93797646
98MYB_26560356_Chip-Seq_TH2_Human0.92593048
99MAF_26560356_Chip-Seq_TH1_Human0.91574591
100BCOR_27268052_Chip-Seq_Bcells_Human0.91566848
101ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90991065
102CTCF_26484167_Chip-Seq_Bcells_Mouse0.89981347
103BCL6_27268052_Chip-Seq_Bcells_Human0.89314559
104PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88719340
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88309507
106CTCF_18555785_ChIP-Seq_MESCs_Mouse0.88095192
107MAF_26560356_Chip-Seq_TH2_Human0.87899304
108FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87111129
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86825061
110ELF1_20517297_ChIP-Seq_JURKAT_Human0.86630774
111UTX_26944678_Chip-Seq_JUKART_Human0.86549993
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85382455
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84886571
114PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.83998165
115RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.83943420
116PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83598372
117BP1_19119308_ChIP-ChIP_Hs578T_Human0.82741411
118PHF8_20622854_ChIP-Seq_HELA_Human0.80429903
119P68_20966046_ChIP-Seq_HELA_Human0.80360424
120HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.78489264

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.59089599
2MP0010094_abnormal_chromosome_stability3.98350099
3MP0003111_abnormal_nucleus_morphology3.73724102
4MP0004957_abnormal_blastocyst_morpholog3.55314072
5MP0008058_abnormal_DNA_repair3.42022137
6MP0003077_abnormal_cell_cycle3.37833216
7MP0008057_abnormal_DNA_replication3.16536247
8MP0003763_abnormal_thymus_physiology2.84331842
9MP0009379_abnormal_foot_pigmentation2.64466355
10MP0008007_abnormal_cellular_replicative2.51674098
11MP0009333_abnormal_splenocyte_physiolog2.46823352
12MP0002396_abnormal_hematopoietic_system2.39858383
13MP0001835_abnormal_antigen_presentation2.36253014
14MP0008877_abnormal_DNA_methylation2.22025967
15MP0000372_irregular_coat_pigmentation2.19565861
16MP0005671_abnormal_response_to2.03047273
17MP0005410_abnormal_fertilization2.02489194
18MP0008932_abnormal_embryonic_tissue1.93473072
19MP0003786_premature_aging1.89021030
20MP0002398_abnormal_bone_marrow1.86664193
21MP0000490_abnormal_crypts_of1.80495020
22MP0000685_abnormal_immune_system1.80350381
23MP0009697_abnormal_copulation1.78773382
24MP0003718_maternal_effect1.78610254
25MP0001853_heart_inflammation1.77121291
26MP0003136_yellow_coat_color1.73985568
27MP0001800_abnormal_humoral_immune1.65709304
28MP0002722_abnormal_immune_system1.63029032
29MP0000689_abnormal_spleen_morphology1.62584920
30MP0003806_abnormal_nucleotide_metabolis1.62267056
31MP0000350_abnormal_cell_proliferation1.61034055
32MP0001730_embryonic_growth_arrest1.60113373
33MP0001929_abnormal_gametogenesis1.59930603
34MP0002132_abnormal_respiratory_system1.57900546
35MP0002420_abnormal_adaptive_immunity1.57715727
36MP0008260_abnormal_autophagy1.57591822
37MP0001819_abnormal_immune_cell1.55699297
38MP0000716_abnormal_immune_system1.53138337
39MP0001545_abnormal_hematopoietic_system1.51610611
40MP0005397_hematopoietic_system_phenotyp1.51610611
41MP0002019_abnormal_tumor_incidence1.51200575
42MP0002210_abnormal_sex_determination1.50261111
43MP0002723_abnormal_immune_serum1.47856110
44MP0009785_altered_susceptibility_to1.47569316
45MP0004808_abnormal_hematopoietic_stem1.47175041
46MP0002452_abnormal_antigen_presenting1.47057349
47MP0002429_abnormal_blood_cell1.46437648
48MP0000703_abnormal_thymus_morphology1.46294609
49MP0005000_abnormal_immune_tolerance1.43239887
50MP0005075_abnormal_melanosome_morpholog1.42961868
51MP0010307_abnormal_tumor_latency1.40148355
52MP0005025_abnormal_response_to1.39656115
53MP0002405_respiratory_system_inflammati1.36459896
54MP0000465_gastrointestinal_hemorrhage1.32928256
55MP0000313_abnormal_cell_death1.30410830
56MP0004147_increased_porphyrin_level1.29504246
57MP0001145_abnormal_male_reproductive1.28671622
58MP0005083_abnormal_biliary_tract1.24013343
59MP0005387_immune_system_phenotype1.22776793
60MP0001790_abnormal_immune_system1.22776793
61MP0005174_abnormal_tail_pigmentation1.22532045
62MP0002148_abnormal_hypersensitivity_rea1.22235716
63MP0000858_altered_metastatic_potential1.20915342
64MP0009840_abnormal_foam_cell1.19290473
65MP0002938_white_spotting1.17410282
66MP0005464_abnormal_platelet_physiology1.15157385
67MP0006292_abnormal_olfactory_placode1.13647844
68MP0006082_CNS_inflammation1.13028698
69MP0000653_abnormal_sex_gland1.11278981
70MP0003011_delayed_dark_adaptation1.11056495
71MP0003436_decreased_susceptibility_to1.10259319
72MP0002736_abnormal_nociception_after1.10169825
73MP0001764_abnormal_homeostasis1.07349399
74MP0003698_abnormal_male_reproductive1.06357746
75MP0005451_abnormal_body_composition1.04981813
76MP0010352_gastrointestinal_tract_polyps1.01780407
77MP0002080_prenatal_lethality1.00936637
78MP0000015_abnormal_ear_pigmentation1.00260405
79MP0008789_abnormal_olfactory_epithelium1.00226656
80MP0005310_abnormal_salivary_gland0.98799022
81MP0004145_abnormal_muscle_electrophysio0.97401618
82MP0001873_stomach_inflammation0.96713022
83MP0008995_early_reproductive_senescence0.96649324
84MP0003656_abnormal_erythrocyte_physiolo0.96327438
85MP0001672_abnormal_embryogenesis/_devel0.96163508
86MP0005380_embryogenesis_phenotype0.96163508
87MP0003186_abnormal_redox_activity0.95788247
88MP0002419_abnormal_innate_immunity0.94636817
89MP0006036_abnormal_mitochondrial_physio0.94421595
90MP0003123_paternal_imprinting0.94180034
91MP0003567_abnormal_fetal_cardiomyocyte0.94161799
92MP0002160_abnormal_reproductive_system0.93982407
93MP0001697_abnormal_embryo_size0.93595368
94MP0005332_abnormal_amino_acid0.93574210
95MP0001905_abnormal_dopamine_level0.93286689
96MP0002095_abnormal_skin_pigmentation0.92935081
97MP0001968_abnormal_touch/_nociception0.91880879
98MP0000678_abnormal_parathyroid_gland0.90882951
99MP0001986_abnormal_taste_sensitivity0.88081340
100MP0009764_decreased_sensitivity_to0.87943068
101MP0003866_abnormal_defecation0.87884266
102MP0006035_abnormal_mitochondrial_morpho0.85844909
103MP0008872_abnormal_physiological_respon0.85838842
104MP0000358_abnormal_cell_content/0.84143116
105MP0001845_abnormal_inflammatory_respons0.84015396
106MP0005389_reproductive_system_phenotype0.83684516
107MP0010155_abnormal_intestine_physiology0.83505159
108MP0002163_abnormal_gland_morphology0.83192451
109MP0002277_abnormal_respiratory_mucosa0.83055793
110MP0009765_abnormal_xenobiotic_induced0.81928477
111MP0003984_embryonic_growth_retardation0.81330795
112MP0003315_abnormal_perineum_morphology0.80309841
113MP0002088_abnormal_embryonic_growth/wei0.78541408
114MP0001119_abnormal_female_reproductive0.78536524
115MP0002653_abnormal_ependyma_morphology0.76276256
116MP0002166_altered_tumor_susceptibility0.75641371
117MP0006072_abnormal_retinal_apoptosis0.74214821
118MP0003172_abnormal_lysosome_physiology0.73955778
119MP0008469_abnormal_protein_level0.73398806
120MP0003699_abnormal_female_reproductive0.72866195
121MP0005636_abnormal_mineral_homeostasis0.72644957
122MP0001293_anophthalmia0.72040431
123MP0009278_abnormal_bone_marrow0.71951004
124MP0002161_abnormal_fertility/fecundity0.68639129
125MP0003646_muscle_fatigue0.68401225

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.78303866
2Abnormality of cells of the erythroid lineage (HP:0012130)4.63437691
3Mitochondrial inheritance (HP:0001427)4.54307206
4Abnormal number of erythroid precursors (HP:0012131)4.49895118
5Acute necrotizing encephalopathy (HP:0006965)4.44875225
6Abnormal mitochondria in muscle tissue (HP:0008316)4.34689303
7Increased hepatocellular lipid droplets (HP:0006565)4.18793170
8Hepatocellular necrosis (HP:0001404)4.15935986
9Acute encephalopathy (HP:0006846)4.07682414
10Increased CSF lactate (HP:0002490)4.04166300
11Reticulocytopenia (HP:0001896)4.03593893
12Aplastic anemia (HP:0001915)3.97319878
13Renal Fanconi syndrome (HP:0001994)3.96306608
14Lipid accumulation in hepatocytes (HP:0006561)3.92645844
15Increased intramyocellular lipid droplets (HP:0012240)3.89321062
16Hepatic necrosis (HP:0002605)3.83494092
17Progressive macrocephaly (HP:0004481)3.47351703
18Breast hypoplasia (HP:0003187)3.43598503
19Increased muscle lipid content (HP:0009058)3.43107559
20Thrombocytosis (HP:0001894)3.40306761
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.26772915
22Oral leukoplakia (HP:0002745)3.20918779
23Elevated erythrocyte sedimentation rate (HP:0003565)3.17382074
24Macrocytic anemia (HP:0001972)3.14331882
25IgM deficiency (HP:0002850)3.11212359
26Petechiae (HP:0000967)3.05321711
27Lactic acidosis (HP:0003128)3.03650078
28Abnormality of the anterior horn cell (HP:0006802)3.02966457
29Degeneration of anterior horn cells (HP:0002398)3.02966457
30Cerebral edema (HP:0002181)3.00519313
31Pallor (HP:0000980)2.94754150
32Recurrent bronchitis (HP:0002837)2.91152921
33Nasal polyposis (HP:0100582)2.89893244
34Rough bone trabeculation (HP:0100670)2.88630183
35Patellar aplasia (HP:0006443)2.82961386
36Type I transferrin isoform profile (HP:0003642)2.80468124
37Exercise intolerance (HP:0003546)2.74895653
38Chronic otitis media (HP:0000389)2.73492574
39Aplasia/Hypoplasia of the patella (HP:0006498)2.73057096
40Absent thumb (HP:0009777)2.72782545
41Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.72267244
42Abnormality of the heme biosynthetic pathway (HP:0010472)2.70840409
43Respiratory difficulties (HP:0002880)2.69418234
44Impulsivity (HP:0100710)2.58404679
45Myelodysplasia (HP:0002863)2.57866492
46Multiple enchondromatosis (HP:0005701)2.57242170
47Abnormal spermatogenesis (HP:0008669)2.57100451
48Cerebral hypomyelination (HP:0006808)2.56619726
49T lymphocytopenia (HP:0005403)2.52813277
50Chromosomal breakage induced by crosslinking agents (HP:0003221)2.52105756
51Paralysis (HP:0003470)2.50203912
52Abnormality of the preputium (HP:0100587)2.49559871
53Bone marrow hypocellularity (HP:0005528)2.49429236
54Abnormality of T cell number (HP:0011839)2.49081833
55Bronchitis (HP:0012387)2.48825554
56Abnormality of T cells (HP:0002843)2.48744733
57Pancytopenia (HP:0001876)2.48649789
58Chromsome breakage (HP:0040012)2.48357458
59Colon cancer (HP:0003003)2.47377216
60Respiratory failure (HP:0002878)2.45541952
61Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.41966732
62Decreased activity of mitochondrial respiratory chain (HP:0008972)2.41966732
63Cleft eyelid (HP:0000625)2.40730142
64Abnormality of the nasal mucosa (HP:0000433)2.39967447
65Microretrognathia (HP:0000308)2.39423138
66Ragged-red muscle fibers (HP:0003200)2.39168620
67Progressive microcephaly (HP:0000253)2.38026367
68IgG deficiency (HP:0004315)2.37624804
6911 pairs of ribs (HP:0000878)2.37236949
70Muscle fiber atrophy (HP:0100295)2.36055976
71Lymphoma (HP:0002665)2.34176529
72Myositis (HP:0100614)2.33509480
73Cellular immunodeficiency (HP:0005374)2.31261214
74Premature graying of hair (HP:0002216)2.30187742
75Microvesicular hepatic steatosis (HP:0001414)2.29285203
76Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27835261
77Abnormal protein N-linked glycosylation (HP:0012347)2.27835261
78Abnormal protein glycosylation (HP:0012346)2.27835261
79Abnormal glycosylation (HP:0012345)2.27835261
80Methylmalonic aciduria (HP:0012120)2.25557324
81Meckel diverticulum (HP:0002245)2.24563827
82Generalized aminoaciduria (HP:0002909)2.23965352
83Abnormality of chromosome stability (HP:0003220)2.23381898
84Carpal bone hypoplasia (HP:0001498)2.22789226
85Aplasia/Hypoplasia of the uvula (HP:0010293)2.19787781
86Abnormality of T cell physiology (HP:0011840)2.18523455
87Poor head control (HP:0002421)2.17156204
88Type 2 muscle fiber atrophy (HP:0003554)2.16182725
89Abnormality of the ileum (HP:0001549)2.14981640
90Recurrent sinusitis (HP:0011108)2.14818104
91Premature ovarian failure (HP:0008209)2.13284917
92Lethargy (HP:0001254)2.10229443
93Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08080806
94Dicarboxylic aciduria (HP:0003215)2.08080806
95Reduced antithrombin III activity (HP:0001976)2.04879574
96Abnormal trabecular bone morphology (HP:0100671)2.04636679
97Hypoplasia of the capital femoral epiphysis (HP:0003090)2.04360375
98Aplasia/Hypoplasia of the sacrum (HP:0008517)2.02856285
99Optic disc pallor (HP:0000543)2.02722145
100Abnormality of renal resorption (HP:0011038)2.02293570
101Asplenia (HP:0001746)2.00978752
102Abnormal respiratory motile cilium morphology (HP:0005938)2.00060396
103Abnormal respiratory epithelium morphology (HP:0012253)2.00060396
104Abnormality of reticulocytes (HP:0004312)1.98764178
105Trismus (HP:0000211)1.98725264
106Progressive external ophthalmoplegia (HP:0000590)1.97221237
107Exertional dyspnea (HP:0002875)1.95783242
108Abnormality of cells of the lymphoid lineage (HP:0012140)1.95038874
109Methylmalonic acidemia (HP:0002912)1.92554004
110Increased serum lactate (HP:0002151)1.92436664
111Neoplasm of the pancreas (HP:0002894)1.89996498
112Bronchiectasis (HP:0002110)1.89021894
113Sloping forehead (HP:0000340)1.89021370
114Small intestinal stenosis (HP:0012848)1.88321790
115Duodenal stenosis (HP:0100867)1.88321790
116Recurrent abscess formation (HP:0002722)1.88090424
117Severe visual impairment (HP:0001141)1.87264735
118Tongue fasciculations (HP:0001308)1.87177779
119Selective tooth agenesis (HP:0001592)1.86145313
120Abnormality of DNA repair (HP:0003254)1.85987212
121Sparse eyelashes (HP:0000653)1.85984056
122Abnormality of the pons (HP:0007361)1.85867046
123Stomatitis (HP:0010280)1.85729810
124Pendular nystagmus (HP:0012043)1.85508709
125Chronic bronchitis (HP:0004469)1.85334502
126Obstructive lung disease (HP:0006536)1.84487506
127Chronic obstructive pulmonary disease (HP:0006510)1.84487506
128Recurrent viral infections (HP:0004429)1.84172298
129Pulmonary fibrosis (HP:0002206)1.83534083
130Glycosuria (HP:0003076)1.83339175
131Abnormality of urine glucose concentration (HP:0011016)1.83339175
132Leukopenia (HP:0001882)1.83245743
133Progressive muscle weakness (HP:0003323)1.83092696
134Lymphopenia (HP:0001888)1.83038174
135Secondary amenorrhea (HP:0000869)1.82673778
136Overlapping toe (HP:0001845)1.81980656
137Increased IgM level (HP:0003496)1.81671126
1383-Methylglutaconic aciduria (HP:0003535)1.81493236
139Megaloblastic anemia (HP:0001889)1.81400747
140Chronic sinusitis (HP:0011109)1.80905818
141Emotional lability (HP:0000712)1.80881357
142Amaurosis fugax (HP:0100576)1.78081811
143Increased serum ferritin (HP:0003281)1.77870716
144CNS demyelination (HP:0007305)1.76929846
145Clubbing of toes (HP:0100760)1.76821584
146Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76488080
147Leukodystrophy (HP:0002415)1.74392137
148Neutropenia (HP:0001875)1.74263847
149Increased serum pyruvate (HP:0003542)1.74165187
150Hyperglycinemia (HP:0002154)1.71952889
151Abnormality of sulfur amino acid metabolism (HP:0004339)1.71833206
152Hypertensive crisis (HP:0100735)1.68939921
153Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67681884
154Abnormality of alanine metabolism (HP:0010916)1.67681884
155Hyperalaninemia (HP:0003348)1.67681884
156Horseshoe kidney (HP:0000085)1.67146822
157Abnormal pupillary function (HP:0007686)1.66951017
158Hypoplastic pelvis (HP:0008839)1.66706691
159Duplicated collecting system (HP:0000081)1.66616683
160Abnormality of aromatic amino acid family metabolism (HP:0004338)1.66255171

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.25664152
2BUB14.09454494
3STK164.07457518
4WEE13.59387000
5CDC73.09898687
6EIF2AK12.96236225
7NME22.94678898
8NME12.76146474
9NEK22.70023709
10ACVR1B2.42653257
11MAP4K12.35316521
12BLK2.11470372
13RPS6KA42.09997259
14PIM22.01112663
15BRSK22.00574049
16TESK21.94666017
17VRK11.92270363
18PLK41.88879057
19EIF2AK31.81032196
20TAF11.81015547
21SRPK11.77015886
22TSSK61.75908827
23ZAP701.71845158
24BRSK11.66023459
25PBK1.53953100
26PLK11.50276987
27MAP4K21.43793734
28DYRK31.43758885
29NUAK11.38112625
30BRAF1.36229786
31TXK1.34853273
32TLK11.34791270
33TESK11.34363470
34DYRK21.32522480
35CHEK21.28435272
36STK101.28229030
37NLK1.26569623
38CDK71.25085305
39PASK1.24581851
40AURKB1.23264999
41IRAK41.21223904
42TAOK31.19797483
43TTK1.19359729
44SMG11.19021284
45TYK21.18840465
46ATR1.18197770
47TEC1.16328435
48AURKA1.13671620
49CDK41.10568904
50PIM11.09969469
51MKNK21.08254630
52CCNB11.07896563
53BTK1.05152103
54KIT1.03827841
55JAK31.02648079
56PDK41.00526679
57PDK31.00526679
58ADRBK20.97342109
59GRK60.94918857
60ARAF0.93773484
61MUSK0.93535200
62IRAK30.92341670
63IKBKB0.91885820
64SYK0.91692187
65KDR0.91513602
66WNK40.89976522
67MKNK10.87826950
68CHEK10.87209922
69IKBKE0.87101795
70RPS6KB20.83366865
71TBK10.82986343
72PLK30.80036751
73BMPR1B0.77452679
74MAP3K80.76672863
75STK40.75559180
76BCKDK0.75053962
77CDK120.72623528
78RPS6KA50.70457144
79NEK10.70428372
80CSNK2A20.70079771
81DAPK10.69176008
82MARK30.67291890
83CSNK2A10.67163433
84PDK20.66749121
85RIPK40.65604341
86ZAK0.63969379
87MAPKAPK30.63845170
88TAOK10.61510184
89EIF2AK20.60519093
90MAPKAPK50.59506173
91PAK10.59331992
92CDK80.59178717
93WNK30.58681851
94CSNK1G30.58483241
95LRRK20.56486610
96CDK20.56079141
97EEF2K0.53338958
98SCYL20.52685814
99CLK10.52123256
100ERN10.52071262
101BMX0.52013407
102PRKCI0.51993753
103CAMKK20.50826171
104CHUK0.49103454
105CSNK1G10.48237838
106TNIK0.47859091
107TNK20.47845918
108ATM0.45823191
109GRK50.45532929
110LCK0.45432572
111LYN0.45283963
112MAPK110.45179838
113ITK0.45024867
114CSF1R0.44869736
115MAP2K20.43735887
116CDK190.42489252
117MAP2K70.40727295
118MAP3K100.39491801
119EPHA20.38926689
120MATK0.38226701
121MAP2K30.37832980
122TAOK20.37723113
123ABL20.36263593
124MAPKAPK20.35389542
125TGFBR10.34490850
126CSNK1G20.33802734
127CDK90.32853448
128ALK0.32159309
129PRKCQ0.31813816
130MST40.30928979
131STK240.29807287
132PKN10.29371507
133OXSR10.28986175
134CSNK1E0.28364046
135MAP3K110.27883360
136RAF10.27826145

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.61130213
2Ribosome_Homo sapiens_hsa030103.97929910
3Mismatch repair_Homo sapiens_hsa034303.79804920
4RNA polymerase_Homo sapiens_hsa030203.62577959
5Proteasome_Homo sapiens_hsa030503.58288843
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.37951826
7Base excision repair_Homo sapiens_hsa034103.09770975
8Homologous recombination_Homo sapiens_hsa034402.92240294
9Spliceosome_Homo sapiens_hsa030402.85146104
10Pyrimidine metabolism_Homo sapiens_hsa002402.65083948
11Nucleotide excision repair_Homo sapiens_hsa034202.64062390
12RNA transport_Homo sapiens_hsa030132.50443175
13Basal transcription factors_Homo sapiens_hsa030222.18946623
14Cell cycle_Homo sapiens_hsa041102.14111393
15Fanconi anemia pathway_Homo sapiens_hsa034602.12477624
16Alzheimers disease_Homo sapiens_hsa050102.03419208
17One carbon pool by folate_Homo sapiens_hsa006701.95474787
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.91681053
19Non-homologous end-joining_Homo sapiens_hsa034501.86937681
20Vitamin B6 metabolism_Homo sapiens_hsa007501.81803843
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.79393019
22Primary immunodeficiency_Homo sapiens_hsa053401.73119082
23RNA degradation_Homo sapiens_hsa030181.57852684
24Folate biosynthesis_Homo sapiens_hsa007901.49304593
25Purine metabolism_Homo sapiens_hsa002301.47462174
26p53 signaling pathway_Homo sapiens_hsa041151.40740413
27Sulfur relay system_Homo sapiens_hsa041221.33958703
28Antigen processing and presentation_Homo sapiens_hsa046121.33110503
29mRNA surveillance pathway_Homo sapiens_hsa030151.28485161
30Epstein-Barr virus infection_Homo sapiens_hsa051691.25160564
31Pentose phosphate pathway_Homo sapiens_hsa000301.23193117
32Cardiac muscle contraction_Homo sapiens_hsa042601.18077819
33Herpes simplex infection_Homo sapiens_hsa051681.11606971
34Protein export_Homo sapiens_hsa030601.10960191
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06472206
36Intestinal immune network for IgA production_Homo sapiens_hsa046720.96234513
37Pyruvate metabolism_Homo sapiens_hsa006200.90480901
38Sulfur metabolism_Homo sapiens_hsa009200.90293522
39Systemic lupus erythematosus_Homo sapiens_hsa053220.86407513
40NF-kappa B signaling pathway_Homo sapiens_hsa040640.85928391
41Other glycan degradation_Homo sapiens_hsa005110.83675558
42Selenocompound metabolism_Homo sapiens_hsa004500.81346635
43Drug metabolism - other enzymes_Homo sapiens_hsa009830.81319591
44Huntingtons disease_Homo sapiens_hsa050160.81007184
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.80239518
46Measles_Homo sapiens_hsa051620.79951972
47Legionellosis_Homo sapiens_hsa051340.76485474
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70942486
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.70756577
50Viral carcinogenesis_Homo sapiens_hsa052030.69755356
51Hematopoietic cell lineage_Homo sapiens_hsa046400.66814742
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64414028
53Propanoate metabolism_Homo sapiens_hsa006400.63882449
54Parkinsons disease_Homo sapiens_hsa050120.63191485
55Allograft rejection_Homo sapiens_hsa053300.59533407
56Apoptosis_Homo sapiens_hsa042100.56800723
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56782805
58Collecting duct acid secretion_Homo sapiens_hsa049660.56190217
59Fructose and mannose metabolism_Homo sapiens_hsa000510.55573329
60Regulation of autophagy_Homo sapiens_hsa041400.55394692
61Rheumatoid arthritis_Homo sapiens_hsa053230.54600277
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54400770
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53475010
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51216502
65Graft-versus-host disease_Homo sapiens_hsa053320.51153778
66Thyroid cancer_Homo sapiens_hsa052160.51123918
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.50737799
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50045537
69Biosynthesis of amino acids_Homo sapiens_hsa012300.49926951
70Shigellosis_Homo sapiens_hsa051310.49906379
71HTLV-I infection_Homo sapiens_hsa051660.49583041
72Fatty acid elongation_Homo sapiens_hsa000620.49301646
73Oocyte meiosis_Homo sapiens_hsa041140.49128185
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48510000
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48380631
76B cell receptor signaling pathway_Homo sapiens_hsa046620.47630323
77Leishmaniasis_Homo sapiens_hsa051400.47612960
78Oxidative phosphorylation_Homo sapiens_hsa001900.46670521
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46342910
80Influenza A_Homo sapiens_hsa051640.45945870
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45256897
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43029520
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40336495
84Peroxisome_Homo sapiens_hsa041460.38221498
85T cell receptor signaling pathway_Homo sapiens_hsa046600.37866208
86Hepatitis B_Homo sapiens_hsa051610.37781108
87Glutathione metabolism_Homo sapiens_hsa004800.37421877
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36774480
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35155859
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34318172
91N-Glycan biosynthesis_Homo sapiens_hsa005100.32570081
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.31666282
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31135376
94Metabolic pathways_Homo sapiens_hsa011000.30941725
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30869196
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29692304
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29633263
98Galactose metabolism_Homo sapiens_hsa000520.29599512
99Acute myeloid leukemia_Homo sapiens_hsa052210.28263885
100Arachidonic acid metabolism_Homo sapiens_hsa005900.27614173
101Steroid biosynthesis_Homo sapiens_hsa001000.26862617
102Linoleic acid metabolism_Homo sapiens_hsa005910.26747542
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26054013
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26013086
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25836238
106Type I diabetes mellitus_Homo sapiens_hsa049400.25651982
107Carbon metabolism_Homo sapiens_hsa012000.25306066
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24862057
109Arginine and proline metabolism_Homo sapiens_hsa003300.23574054
110Alcoholism_Homo sapiens_hsa050340.22350446
111Fatty acid metabolism_Homo sapiens_hsa012120.19667539
112Small cell lung cancer_Homo sapiens_hsa052220.19659625
113Vitamin digestion and absorption_Homo sapiens_hsa049770.19339597
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18674382
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17225156
116Nitrogen metabolism_Homo sapiens_hsa009100.16612708
117Tryptophan metabolism_Homo sapiens_hsa003800.15869144
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.15754477
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.15054127
120Asthma_Homo sapiens_hsa053100.13513198
121Autoimmune thyroid disease_Homo sapiens_hsa053200.13085530
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12544017
123Osteoclast differentiation_Homo sapiens_hsa043800.11780934
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.11629535
125Toxoplasmosis_Homo sapiens_hsa051450.11602792
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11520626

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