GPAT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA methylation involved in gamete generation (GO:0043046)9.18476688
2synaptonemal complex assembly (GO:0007130)8.65772447
3male meiosis (GO:0007140)8.40674650
4synaptonemal complex organization (GO:0070193)8.37820930
5regulation of meiosis I (GO:0060631)8.32003003
6meiotic nuclear division (GO:0007126)6.43614264
7chromosome organization involved in meiosis (GO:0070192)6.43086465
8male meiosis I (GO:0007141)6.00912641
9gene silencing by RNA (GO:0031047)5.60507882
10nuclear pore complex assembly (GO:0051292)5.41752008
11nuclear pore organization (GO:0006999)5.35616167
12fusion of sperm to egg plasma membrane (GO:0007342)5.06203978
13meiosis I (GO:0007127)5.06059455
14cilium or flagellum-dependent cell motility (GO:0001539)4.93388125
15DNA methylation (GO:0006306)4.71983337
16DNA alkylation (GO:0006305)4.71983337
17meiotic cell cycle process (GO:1903046)4.68697094
18heterochromatin organization (GO:0070828)4.58936869
19binding of sperm to zona pellucida (GO:0007339)4.56314645
20spermatid development (GO:0007286)4.46811706
21sperm-egg recognition (GO:0035036)4.41439361
22positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.31214973
23barbed-end actin filament capping (GO:0051016)4.31183530
24oogenesis (GO:0048477)4.30159139
25gene silencing (GO:0016458)4.29642916
26regulation of posttranscriptional gene silencing (GO:0060147)4.22029184
27regulation of gene silencing by miRNA (GO:0060964)4.22029184
28regulation of gene silencing by RNA (GO:0060966)4.22029184
29DNA replication-dependent nucleosome assembly (GO:0006335)4.14984997
30DNA replication-dependent nucleosome organization (GO:0034723)4.14984997
31regulation of histone H3-K9 methylation (GO:0051570)4.12917634
32germ cell development (GO:0007281)4.08099936
33chaperone-mediated protein complex assembly (GO:0051131)4.07210786
34negative regulation of meiosis (GO:0045835)4.07156388
35meiotic cell cycle (GO:0051321)4.07132783
36pore complex assembly (GO:0046931)4.04380527
37oocyte development (GO:0048599)4.03930577
38sperm motility (GO:0030317)4.03755610
39reciprocal DNA recombination (GO:0035825)3.99376469
40reciprocal meiotic recombination (GO:0007131)3.99376469
41pinocytosis (GO:0006907)3.98584671
42cell-cell recognition (GO:0009988)3.92070939
43meiotic chromosome segregation (GO:0045132)3.90747995
44negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.88301782
45regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.88147663
46synapsis (GO:0007129)3.86935952
47sister chromatid cohesion (GO:0007062)3.85771416
48sex differentiation (GO:0007548)3.82520269
49protein maturation by protein folding (GO:0022417)3.81704089
50mitotic chromosome condensation (GO:0007076)3.80245555
51DNA methylation or demethylation (GO:0044728)3.76660075
52pre-miRNA processing (GO:0031054)3.75717257
53chaperone mediated protein folding requiring cofactor (GO:0051085)3.69316985
54GDP-mannose metabolic process (GO:0019673)3.63993053
55protein localization to endosome (GO:0036010)3.60068297
56plasma membrane fusion (GO:0045026)3.59889244
57positive regulation of meiosis (GO:0045836)3.54201680
58histone H4-K12 acetylation (GO:0043983)3.54006268
59mitotic nuclear envelope disassembly (GO:0007077)3.52839186
60axonemal dynein complex assembly (GO:0070286)3.52779691
61amino sugar catabolic process (GO:0046348)3.51229661
62attachment of spindle microtubules to kinetochore (GO:0008608)3.43982551
63male gamete generation (GO:0048232)3.43813638
64spermatogenesis (GO:0007283)3.43798103
65mitotic sister chromatid segregation (GO:0000070)3.43546699
66acrosome assembly (GO:0001675)3.39267660
67protein K6-linked ubiquitination (GO:0085020)3.38161544
68microtubule depolymerization (GO:0007019)3.37480653
69DNA packaging (GO:0006323)3.35008831
70membrane disassembly (GO:0030397)3.33236837
71nuclear envelope disassembly (GO:0051081)3.33236837
72deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.31965811
73cellular process involved in reproduction in multicellular organism (GO:0022412)3.31210804
74chromatin assembly (GO:0031497)3.29403960
75positive regulation of meiotic cell cycle (GO:0051446)3.29182933
76chromosome condensation (GO:0030261)3.27849434
77mitotic sister chromatid cohesion (GO:0007064)3.26442350
78regulation of centriole replication (GO:0046599)3.22451991
79adenosine receptor signaling pathway (GO:0001973)3.21981174
80female gamete generation (GO:0007292)3.21225661
81resolution of meiotic recombination intermediates (GO:0000712)3.20295968
82regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.18692945
83regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.18668709
84gamete generation (GO:0007276)3.18456376
85negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.16969353
86regulation of cilium movement (GO:0003352)3.16307405
87COPI coating of Golgi vesicle (GO:0048205)3.15311176
88Golgi transport vesicle coating (GO:0048200)3.15311176
89mannose metabolic process (GO:0006013)3.15087959
90regulation of protein polyubiquitination (GO:1902914)3.14856349
91DNA modification (GO:0006304)3.14289777
92regulation of monocyte differentiation (GO:0045655)3.11849772
93multicellular organism reproduction (GO:0032504)3.11627672
94regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.11228017
95histone H4-K5 acetylation (GO:0043981)3.11144733
96histone H4-K8 acetylation (GO:0043982)3.11144733
97ceramide catabolic process (GO:0046514)3.10928079
98regulation of chromosome segregation (GO:0051983)3.10362401
99positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.09487376
100somatic diversification of immune receptors via somatic mutation (GO:0002566)3.08551131
101somatic hypermutation of immunoglobulin genes (GO:0016446)3.08551131
102DNA synthesis involved in DNA repair (GO:0000731)3.08141166
103negative regulation of chromosome segregation (GO:0051985)3.05816058
104protein localization to chromosome, centromeric region (GO:0071459)3.05111289
105positive thymic T cell selection (GO:0045059)3.04506211
106chromosome organization (GO:0051276)3.04255018
107motile cilium assembly (GO:0044458)3.03267703
108membrane raft organization (GO:0031579)3.00162408
109DNA unwinding involved in DNA replication (GO:0006268)2.99308342
110epithelial cilium movement (GO:0003351)2.98741283
111sister chromatid segregation (GO:0000819)2.95539276
112epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.95151058
113histone H3-K9 methylation (GO:0051567)2.94740825
114histone exchange (GO:0043486)2.93990266
115protein localization to kinetochore (GO:0034501)2.93257837
116negative regulation of DNA repair (GO:0045738)2.92615994
117DNA replication checkpoint (GO:0000076)2.91236930
118negative regulation of mitotic sister chromatid separation (GO:2000816)2.90930033
119negative regulation of mitotic sister chromatid segregation (GO:0033048)2.90930033
120negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.90930033
121negative regulation of sister chromatid segregation (GO:0033046)2.90930033
122negative regulation of erythrocyte differentiation (GO:0045647)2.90700691
123fertilization (GO:0009566)2.90020696
124response to muramyl dipeptide (GO:0032495)2.89211761
125NIK/NF-kappaB signaling (GO:0038061)2.88177808
126protoporphyrinogen IX biosynthetic process (GO:0006782)2.85018121
127negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.79850169
128glucosamine-containing compound catabolic process (GO:1901072)2.78371730
129UV protection (GO:0009650)2.77992988
130cellular response to exogenous dsRNA (GO:0071360)2.77978449
131G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.77450751
132antigen processing and presentation of endogenous antigen (GO:0019883)2.77322719
133antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.76640769
134oligosaccharide catabolic process (GO:0009313)2.76542633
135pyrimidine nucleoside salvage (GO:0043097)2.75140498
136pyrimidine-containing compound salvage (GO:0008655)2.75140498
137negative regulation of interleukin-8 production (GO:0032717)2.72498994
138G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.69687958
139negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.68849777
140antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.67408933
141glycosphingolipid catabolic process (GO:0046479)2.67002566
142immunoglobulin mediated immune response (GO:0016064)2.65190071
143regulation of vitamin D biosynthetic process (GO:0060556)2.59422546
144macrophage differentiation (GO:0030225)2.58976316
145positive regulation of myotube differentiation (GO:0010831)2.55809614
146nucleotide salvage (GO:0043173)2.54802160
147glycolipid catabolic process (GO:0019377)2.54734912
148response to peptidoglycan (GO:0032494)2.52385708
149regulation of skeletal muscle contraction (GO:0014819)2.49792762
150poly(A)+ mRNA export from nucleus (GO:0016973)2.47380753
151regulation of interferon-beta biosynthetic process (GO:0045357)2.46430316
152positive regulation of B cell differentiation (GO:0045579)2.44539737
153positive regulation of defense response to virus by host (GO:0002230)2.44331576
154maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.44257410
155cellular response to virus (GO:0098586)2.43977214
156phosphatidylglycerol biosynthetic process (GO:0006655)2.43148890
157positive regulation of gamma-delta T cell activation (GO:0046645)2.42078679
158regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.39334147
159nucleoside salvage (GO:0043174)2.39243404
160regulation of defense response to virus by host (GO:0050691)2.36510967
161pentose metabolic process (GO:0019321)2.36218126
162germinal center formation (GO:0002467)2.35678128
163Arp2/3 complex-mediated actin nucleation (GO:0034314)2.35530874
164regulation of type I interferon-mediated signaling pathway (GO:0060338)2.34844987
165establishment of viral latency (GO:0019043)2.33047073
166positive regulation of antigen processing and presentation (GO:0002579)2.30760623
167negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.30537015
168negative regulation of response to biotic stimulus (GO:0002832)2.29578631
169cellular response to interleukin-4 (GO:0071353)2.28273222
170protein retention in ER lumen (GO:0006621)2.26732672
171sphingolipid catabolic process (GO:0030149)2.25692424
172negative regulation of nitric oxide biosynthetic process (GO:0045019)2.25506143
173lipopolysaccharide-mediated signaling pathway (GO:0031663)2.24470176
174lymphocyte chemotaxis (GO:0048247)2.24320952
175regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.24263865
176regulation of cytokine production involved in inflammatory response (GO:1900015)2.23912555
177AMP metabolic process (GO:0046033)2.23850287
178membrane lipid catabolic process (GO:0046466)2.23735312
179negative regulation of interleukin-2 production (GO:0032703)2.23510924
180thymic T cell selection (GO:0045061)2.22436801
181macrophage chemotaxis (GO:0048246)2.21415173
182nucleoside transmembrane transport (GO:1901642)2.20081769
183positive regulation of neutrophil migration (GO:1902624)2.19290601
184positive regulation of neutrophil chemotaxis (GO:0090023)2.19290601
185peptide catabolic process (GO:0043171)2.18551378
186positive regulation of tissue remodeling (GO:0034105)2.17485753
187amyloid precursor protein catabolic process (GO:0042987)2.16856998
188regulation of tumor necrosis factor production (GO:0032680)2.16637522
189regulation of necroptotic process (GO:0060544)2.16622974
190cellular response to arsenic-containing substance (GO:0071243)2.15719664
191piRNA metabolic process (GO:0034587)12.2803996

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.24341437
2E2F7_22180533_ChIP-Seq_HELA_Human7.18755428
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.13267807
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.76427264
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.76427264
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.76427264
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.11095506
8VDR_21846776_ChIP-Seq_THP-1_Human3.06097580
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.06023355
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.86036629
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.68228394
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.49030303
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.40254377
14POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.38633303
15AR_21909140_ChIP-Seq_LNCAP_Human2.30229011
16MYC_22102868_ChIP-Seq_BL_Human2.23974938
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.22911895
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.22682261
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20136829
20MYCN_18555785_ChIP-Seq_MESCs_Mouse2.16538010
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.12726445
22LXR_22292898_ChIP-Seq_THP-1_Human2.12104775
23STAT3_1855785_ChIP-Seq_MESCs_Mouse2.09320548
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08434063
25BP1_19119308_ChIP-ChIP_Hs578T_Human2.04683565
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.99510729
27CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.97979229
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.97476366
29NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96862435
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.95320327
31VDR_24763502_ChIP-Seq_THP-1_Human1.94437766
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.93881626
33NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.86966457
34P68_20966046_ChIP-Seq_HELA_Human1.86146995
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.80584635
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80059036
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.79242357
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.73922679
39MAF_26560356_Chip-Seq_TH2_Human1.71833244
40MAF_26560356_Chip-Seq_TH1_Human1.71438711
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68426683
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66153904
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63172587
44BCL6_27268052_Chip-Seq_Bcells_Human1.62858238
45XRN2_22483619_ChIP-Seq_HELA_Human1.62589912
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.62148598
47ELF1_20517297_ChIP-Seq_JURKAT_Human1.61122375
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60204570
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.57656128
50BCOR_27268052_Chip-Seq_Bcells_Human1.56971199
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56790135
52* TET1_21451524_ChIP-Seq_MESCs_Mouse1.56046677
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.55356831
54RACK7_27058665_Chip-Seq_MCF-7_Human1.55226966
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.53080125
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.52937694
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52202408
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50533760
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50078089
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49608387
61CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49147702
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.48165815
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.46388834
64KDM5A_27292631_Chip-Seq_BREAST_Human1.43138345
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43099114
66MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43084025
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42923737
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.42851682
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42734708
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42602297
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39066884
72SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38220275
73UTX_26944678_Chip-Seq_JUKART_Human1.37795411
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.37465639
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.37216116
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36956331
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36141931
78ETS1_20019798_ChIP-Seq_JURKAT_Human1.36074189
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.35537732
80NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35475360
81SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.34733357
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34102741
83EST1_17652178_ChIP-ChIP_JURKAT_Human1.33277651
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33033166
85* TCF7_22412390_ChIP-Seq_EML_Mouse1.31460492
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30910979
87ATF3_27146783_Chip-Seq_COLON_Human1.30567080
88DCP1A_22483619_ChIP-Seq_HELA_Human1.30089802
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29766673
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.29563655
91GATA1_26923725_Chip-Seq_HPCs_Mouse1.28752082
92E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27785558
93POU5F1_16518401_ChIP-PET_MESCs_Mouse1.27588822
94ZNF263_19887448_ChIP-Seq_K562_Human1.27390990
95SPI1_23547873_ChIP-Seq_NB4_Human1.27212053
96ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27157871
97ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26879055
98CTCF_21964334_Chip-Seq_Bcells_Human1.26310018
99PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26094097
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.25572001
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24644166
102PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24571817
103E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24400227
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23123707
105GABP_19822575_ChIP-Seq_HepG2_Human1.22720913
106ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20985898
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20970066
108CTCF_26484167_Chip-Seq_Bcells_Mouse1.20904524
109SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20348795
110KDM2B_26808549_Chip-Seq_DND41_Human1.19857506
111TCF3_18692474_ChIP-Seq_MESCs_Mouse1.18635870
112YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18293371
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18106971
114EGR1_19374776_ChIP-ChIP_THP-1_Human1.17538259
115THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16185472
116GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15528848
117SA1_27219007_Chip-Seq_ERYTHROID_Human1.15193022
118UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14734990
119THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14711269
120NANOG_21062744_ChIP-ChIP_HESCs_Human1.14546457
121* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13422491
122SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12603479
123RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12381322
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12117394
125HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11288927
126RARA_24833708_ChIP-Seq_LIVER_Mouse1.11135758
127* RARB_24833708_ChIP-Seq_LIVER_Mouse1.09402243
128* E2F1_20622854_ChIP-Seq_HELA_Human1.08787537
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08599657
130POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07698306
131SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07224800
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07208235
133STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06270606
134TP53_22127205_ChIP-Seq_IMR90_Human1.06235231
135SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06003695
136CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05844016
137PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05830766
138FOXP3_21729870_ChIP-Seq_TREG_Human1.05783966
139TTF2_22483619_ChIP-Seq_HELA_Human1.05591175
140SOX2_18692474_ChIP-Seq_MESCs_Mouse1.05452880
141VDR_23849224_ChIP-Seq_CD4+_Human1.05237799
142RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03275794
143DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01778113
144SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01546786
145CIITA_25753668_ChIP-Seq_RAJI_Human1.01242212
146PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99725603
147CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98896767
148NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98303335
149POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.97995953
150NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97292158
151HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96469775
152ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95790918
153YY1_22570637_ChIP-Seq_MALME-3M_Human0.95012335
154E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93830775
155TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92786650
156NANOG_18692474_ChIP-Seq_MESCs_Mouse0.92356365
157CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90997529
158SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90984643
159TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90718970
160NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.90106648
161PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84588063
162KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.83463983
163PHF8_20622854_ChIP-Seq_HELA_Human0.81203053
164* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80243935
165RBPJ_22232070_ChIP-Seq_NCS_Mouse0.79838513
166NANOG_18692474_ChIP-Seq_MEFs_Mouse0.79133509
167PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.79118240
168TFEB_21752829_ChIP-Seq_HELA_Human0.78128415
169GABP_17652178_ChIP-ChIP_JURKAT_Human0.77788780
170KAP1_27257070_Chip-Seq_ESCs_Mouse0.77714665
171NANOG_16518401_ChIP-PET_MESCs_Mouse0.76028650
172BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75853400
173TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.73999246
174ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.73901998

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation7.99657005
2MP0005410_abnormal_fertilization4.88282338
3MP0008057_abnormal_DNA_replication4.43916880
4MP0001929_abnormal_gametogenesis3.97433313
5MP0002210_abnormal_sex_determination3.93742257
6MP0010094_abnormal_chromosome_stability3.90939926
7MP0008995_early_reproductive_senescence3.55323190
8MP0003698_abnormal_male_reproductive3.55229055
9MP0005058_abnormal_lysosome_morphology3.54926572
10MP0001145_abnormal_male_reproductive3.32169152
11MP0003111_abnormal_nucleus_morphology3.19036734
12MP0005451_abnormal_body_composition3.18527921
13MP0001881_abnormal_mammary_gland3.17061191
14MP0008058_abnormal_DNA_repair3.08533023
15MP0002877_abnormal_melanocyte_morpholog3.02054335
16MP0004957_abnormal_blastocyst_morpholog2.92671567
17MP0003786_premature_aging2.92249714
18MP0000653_abnormal_sex_gland2.88053193
19MP0003693_abnormal_embryo_hatching2.65727139
20MP0003077_abnormal_cell_cycle2.62410581
21MP0000751_myopathy2.59228311
22MP0003436_decreased_susceptibility_to2.53870195
23MP0002653_abnormal_ependyma_morphology2.49070384
24MP0003191_abnormal_cellular_cholesterol2.46545486
25MP0003303_peritoneal_inflammation2.21638702
26MP0002161_abnormal_fertility/fecundity2.10504167
27MP0001730_embryonic_growth_arrest2.06285007
28MP0001835_abnormal_antigen_presentation1.93481866
29MP0002822_catalepsy1.88021881
30MP0002148_abnormal_hypersensitivity_rea1.84511995
31MP0009333_abnormal_splenocyte_physiolog1.83362241
32MP0009840_abnormal_foam_cell1.81925733
33MP0010307_abnormal_tumor_latency1.79743354
34MP0001853_heart_inflammation1.76509342
35MP0002160_abnormal_reproductive_system1.75710815
36MP0002419_abnormal_innate_immunity1.75666414
37MP0003123_paternal_imprinting1.72702856
38MP0005671_abnormal_response_to1.72418583
39MP0003763_abnormal_thymus_physiology1.68617835
40MP0002452_abnormal_antigen_presenting1.68368150
41MP0003453_abnormal_keratinocyte_physiol1.66786181
42MP0008007_abnormal_cellular_replicative1.66188990
43MP0005330_cardiomyopathy1.66178094
44MP0004947_skin_inflammation1.63702727
45MP0002723_abnormal_immune_serum1.57330043
46MP0000350_abnormal_cell_proliferation1.57324127
47MP0010352_gastrointestinal_tract_polyps1.56907221
48MP0000685_abnormal_immune_system1.56290674
49MP0001790_abnormal_immune_system1.56177168
50MP0005387_immune_system_phenotype1.56177168
51MP0005377_hearing/vestibular/ear_phenot1.55276689
52MP0003878_abnormal_ear_physiology1.55276689
53MP0005464_abnormal_platelet_physiology1.53258246
54MP0004185_abnormal_adipocyte_glucose1.52962408
55MP0005000_abnormal_immune_tolerance1.51674807
56MP0008932_abnormal_embryonic_tissue1.51624081
57MP0005380_embryogenesis_phenotype1.51579364
58MP0001672_abnormal_embryogenesis/_devel1.51579364
59MP0005025_abnormal_response_to1.50385733
60MP0003890_abnormal_embryonic-extraembry1.48994432
61MP0003172_abnormal_lysosome_physiology1.47493164
62MP0010234_abnormal_vibrissa_follicle1.47011829
63MP0001800_abnormal_humoral_immune1.46674147
64MP0002420_abnormal_adaptive_immunity1.45778599
65MP0001819_abnormal_immune_cell1.44177499
66MP0000858_altered_metastatic_potential1.43293176
67MP0002084_abnormal_developmental_patter1.42446178
68MP0004197_abnormal_fetal_growth/weight/1.42360336
69MP0000343_altered_response_to1.38740633
70MP0002332_abnormal_exercise_endurance1.36263358
71MP0005257_abnormal_intraocular_pressure1.35564705
72MP0000003_abnormal_adipose_tissue1.35408184
73MP0001293_anophthalmia1.34930088
74MP0002085_abnormal_embryonic_tissue1.32844096
75MP0004510_myositis1.31738935
76MP0000733_abnormal_muscle_development1.30153573
77MP0001697_abnormal_embryo_size1.29876302
78MP0000749_muscle_degeneration1.29789937
79MP0003984_embryonic_growth_retardation1.29693259
80MP0005174_abnormal_tail_pigmentation1.29022582
81MP0002088_abnormal_embryonic_growth/wei1.25404901
82MP0003806_abnormal_nucleotide_metabolis1.25247887
83MP0005076_abnormal_cell_differentiation1.24628360
84MP0003950_abnormal_plasma_membrane1.23709645
85MP0001119_abnormal_female_reproductive1.22985382
86MP0001873_stomach_inflammation1.22529902
87MP0003566_abnormal_cell_adhesion1.20779205
88MP0002086_abnormal_extraembryonic_tissu1.19297924
89MP0000604_amyloidosis1.19208638
90MP0001533_abnormal_skeleton_physiology1.18872094
91MP0005647_abnormal_sex_gland1.17340060
92MP0000627_abnormal_mammary_gland1.17083117
93MP0005083_abnormal_biliary_tract1.16685134
94MP0000013_abnormal_adipose_tissue1.16580865
95MP0005501_abnormal_skin_physiology1.15860038
96MP0002006_tumorigenesis1.15395724
97MP0002398_abnormal_bone_marrow1.15048593
98MP0002080_prenatal_lethality1.14228396
99MP0003959_abnormal_lean_body1.12504505
100MP0000716_abnormal_immune_system1.12276260
101MP0005389_reproductive_system_phenotype1.09247746
102MP0004130_abnormal_muscle_cell1.09026492
103MP0008260_abnormal_autophagy1.07518745
104MP0001845_abnormal_inflammatory_respons1.06854309
105MP0000678_abnormal_parathyroid_gland1.06619265
106MP0005623_abnormal_meninges_morphology1.05752353
107MP0005165_increased_susceptibility_to1.05355956
108MP0000313_abnormal_cell_death1.05116909
109MP0000759_abnormal_skeletal_muscle1.05082563
110MP0003656_abnormal_erythrocyte_physiolo1.04737950
111MP0002429_abnormal_blood_cell1.04713583
112MP0002060_abnormal_skin_morphology1.04113199
113MP0005310_abnormal_salivary_gland1.03836660
114MP0003329_amyloid_beta_deposits1.02764220
115MP0003699_abnormal_female_reproductive1.01927557
116MP0001545_abnormal_hematopoietic_system1.01721229
117MP0005397_hematopoietic_system_phenotyp1.01721229
118MP0005375_adipose_tissue_phenotype1.01196050
119MP0003075_altered_response_to0.99418931
120MP0003091_abnormal_cell_migration0.99290761
121MP0009785_altered_susceptibility_to0.98827634
122MP0000015_abnormal_ear_pigmentation0.97811449
123MP0002396_abnormal_hematopoietic_system0.97757556
124MP0003121_genomic_imprinting0.95858127
125MP0003119_abnormal_digestive_system0.95182594
126MP0003718_maternal_effect0.94919028
127MP0008469_abnormal_protein_level0.94428547
128MP0002722_abnormal_immune_system0.94392574
129MP0003448_altered_tumor_morphology0.94343336
130MP0001216_abnormal_epidermal_layer0.92001976
131MP0005666_abnormal_adipose_tissue0.91765683
132MP0002405_respiratory_system_inflammati0.91450116
133MP0002933_joint_inflammation0.91276010
134MP0004233_abnormal_muscle_weight0.91003598
135MP0000747_muscle_weakness0.90543463
136MP0000689_abnormal_spleen_morphology0.88563943
137MP0004858_abnormal_nervous_system0.88462786
138MP0002697_abnormal_eye_size0.88230146
139MP0000750_abnormal_muscle_regeneration0.87282025
140MP0001243_abnormal_dermal_layer0.86644867
141MP0009672_abnormal_birth_weight0.86501545
142MP0003936_abnormal_reproductive_system0.85088544
143MP0008874_decreased_physiological_sensi0.84828164
144MP0003283_abnormal_digestive_organ0.79742244
145MP0002092_abnormal_eye_morphology0.77987965
146MP0009703_decreased_birth_body0.76217355
147MP0004133_heterotaxia0.74665487
148MP0003567_abnormal_fetal_cardiomyocyte0.74164297
149MP0001661_extended_life_span0.73667306
150MP0009278_abnormal_bone_marrow0.70747064
151MP0003705_abnormal_hypodermis_morpholog0.69473563
152MP0002019_abnormal_tumor_incidence0.69377784
153MP0003115_abnormal_respiratory_system0.68748904
154MP0005266_abnormal_metabolism0.67565828
155MP0003632_abnormal_nervous_system0.66640599
156MP0003861_abnormal_nervous_system0.66420721
157MP0005670_abnormal_white_adipose0.65621321
158MP0001915_intracranial_hemorrhage0.65269086
159MP0000358_abnormal_cell_content/0.64295346
160MP0003937_abnormal_limbs/digits/tail_de0.63022779
161MP0004264_abnormal_extraembryonic_tissu0.60445824
162MP0002638_abnormal_pupillary_reflex0.58567976
163MP0005391_vision/eye_phenotype0.58172416
164MP0002127_abnormal_cardiovascular_syste0.57841419
165MP0002269_muscular_atrophy0.56145063
166MP0001849_ear_inflammation0.55036539
167MP0002254_reproductive_system_inflammat0.52915320
168MP0002751_abnormal_autonomic_nervous0.52313420
169MP0008872_abnormal_physiological_respon0.50396083
170MP0003315_abnormal_perineum_morphology0.50179491
171MP0003221_abnormal_cardiomyocyte_apopto0.47946307
172MP0004808_abnormal_hematopoietic_stem0.47671520
173MP0000537_abnormal_urethra_morphology0.47036399
174MP0003941_abnormal_skin_development0.46668149
175MP0005384_cellular_phenotype0.45309031
176MP0003646_muscle_fatigue0.44145270
177MP0005621_abnormal_cell_physiology0.43623298
178MP0001727_abnormal_embryo_implantation0.43170842
179MP0003787_abnormal_imprinting0.41770851
180MP0009053_abnormal_anal_canal0.41163126
181MP0000432_abnormal_head_morphology0.39995017
182MP0006072_abnormal_retinal_apoptosis0.39395975
183MP0003011_delayed_dark_adaptation0.39359978
184MP0000428_abnormal_craniofacial_morphol0.38881369
185MP0005085_abnormal_gallbladder_physiolo0.38484122
186MP0000534_abnormal_ureter_morphology0.37565068

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)5.97667275
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.76921473
3Impulsivity (HP:0100710)5.34340680
4Gonadotropin excess (HP:0000837)5.10407246
5Azoospermia (HP:0000027)4.92154503
6Absent/shortened dynein arms (HP:0200106)4.81891071
7Dynein arm defect of respiratory motile cilia (HP:0012255)4.81891071
8Abnormal spermatogenesis (HP:0008669)4.70089705
9Abnormality of liposaccharide metabolism (HP:0010968)4.30561377
10Abnormality of glycosphingolipid metabolism (HP:0004343)4.30561377
11Abnormality of glycolipid metabolism (HP:0010969)4.30561377
12Ependymoma (HP:0002888)4.09171713
13Testicular atrophy (HP:0000029)3.97600450
14Chromsome breakage (HP:0040012)3.61501682
15Abnormal respiratory motile cilium physiology (HP:0012261)3.49919046
16Selective tooth agenesis (HP:0001592)3.44539463
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.43863173
1811 pairs of ribs (HP:0000878)3.33663105
19Abnormal respiratory epithelium morphology (HP:0012253)3.33605354
20Abnormal respiratory motile cilium morphology (HP:0005938)3.33605354
21Upper motor neuron abnormality (HP:0002127)3.31955723
22Astrocytoma (HP:0009592)3.29654871
23Abnormality of the astrocytes (HP:0100707)3.29654871
24Ragged-red muscle fibers (HP:0003200)3.26519059
25Progressive muscle weakness (HP:0003323)3.26010306
26Infertility (HP:0000789)3.24912018
27Rhinitis (HP:0012384)3.17339653
28Male infertility (HP:0003251)3.15288375
29Amyotrophic lateral sclerosis (HP:0007354)3.10546553
30Hepatosplenomegaly (HP:0001433)3.05697446
31Vacuolated lymphocytes (HP:0001922)3.01935229
32Supernumerary spleens (HP:0009799)3.01465515
33Medulloblastoma (HP:0002885)2.96464734
34Heterotopia (HP:0002282)2.91162800
35Increased cerebral lipofuscin (HP:0011813)2.86029392
36Dysostosis multiplex (HP:0000943)2.85451157
37Chronic bronchitis (HP:0004469)2.82690994
38Rhabdomyosarcoma (HP:0002859)2.81927319
39Degeneration of anterior horn cells (HP:0002398)2.78463404
40Abnormality of the anterior horn cell (HP:0006802)2.78463404
41Tongue fasciculations (HP:0001308)2.77109019
42Ectopic kidney (HP:0000086)2.72430992
43Distal lower limb muscle weakness (HP:0009053)2.72202476
44Hypertensive crisis (HP:0100735)2.71201400
45Premature ovarian failure (HP:0008209)2.70244834
46Missing ribs (HP:0000921)2.66553458
47Progressive external ophthalmoplegia (HP:0000590)2.65846058
48Hand muscle atrophy (HP:0009130)2.65815168
49Poikiloderma (HP:0001029)2.63210173
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.63118247
51Glioma (HP:0009733)2.63093270
52Neoplasm of striated muscle (HP:0009728)2.63010774
53Abnormality of chromosome stability (HP:0003220)2.56880443
54Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.54574646
55Nasal polyposis (HP:0100582)2.53861769
56Neoplasm of the oral cavity (HP:0100649)2.52749753
57Abnormality of the labia minora (HP:0012880)2.52629656
58Meckel diverticulum (HP:0002245)2.52039607
59Absent thumb (HP:0009777)2.51814581
60Muscle fibrillation (HP:0010546)2.51589641
61Fatigue (HP:0012378)2.51528166
62Short humerus (HP:0005792)2.51012663
63Aplasia/hypoplasia of the humerus (HP:0006507)2.50258772
64Fibular hypoplasia (HP:0003038)2.50181726
65Microvesicular hepatic steatosis (HP:0001414)2.49267401
66Orthostatic hypotension (HP:0001278)2.48619374
67Abnormality of the ileum (HP:0001549)2.46896892
68Abnormal ciliary motility (HP:0012262)2.46825153
69Centrally nucleated skeletal muscle fibers (HP:0003687)2.45647939
70Thin bony cortex (HP:0002753)2.45507265
71Mesangial abnormality (HP:0001966)2.44181328
72Increased neuronal autofluorescent lipopigment (HP:0002074)2.42528541
73Neoplasm of head and neck (HP:0012288)2.38306517
74Esophageal neoplasm (HP:0100751)2.38306517
75Nephronophthisis (HP:0000090)2.36712171
76Asymmetric septal hypertrophy (HP:0001670)2.35431661
77Joint stiffness (HP:0001387)2.33835235
78Entropion (HP:0000621)2.33592928
79Agammaglobulinemia (HP:0004432)2.33447637
80Duodenal stenosis (HP:0100867)2.32990453
81Small intestinal stenosis (HP:0012848)2.32990453
82Rhabdomyolysis (HP:0003201)2.31553319
83Chronic mucocutaneous candidiasis (HP:0002728)2.30332760
84Recurrent cutaneous fungal infections (HP:0011370)2.30332760
85Distal lower limb amyotrophy (HP:0008944)2.30150872
86Difficulty climbing stairs (HP:0003551)2.29351920
87Facial hemangioma (HP:0000329)2.22835312
88Abnormality of polysaccharide metabolism (HP:0011012)2.22277444
89Abnormality of glycosaminoglycan metabolism (HP:0004371)2.22277444
90Abnormality of mucopolysaccharide metabolism (HP:0011020)2.22277444
91Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21861726
92Colon cancer (HP:0003003)2.20097174
93Type I transferrin isoform profile (HP:0003642)2.19885027
94Abnormality of the preputium (HP:0100587)2.19491512
95Metaphyseal cupping (HP:0003021)2.18996162
96Nephroblastoma (Wilms tumor) (HP:0002667)2.17869383
97Tubulointerstitial nephritis (HP:0001970)2.15937017
98Increased connective tissue (HP:0009025)2.14909399
99Recurrent viral infections (HP:0004429)2.14730868
100Hypopigmentation of the fundus (HP:0007894)2.14533084
101Absent radius (HP:0003974)2.12988919
102Hypergonadotropic hypogonadism (HP:0000815)2.10410096
103Sloping forehead (HP:0000340)2.08946053
104Increased muscle lipid content (HP:0009058)2.08293411
105Abnormality of macrophages (HP:0004311)2.07319421
106Amniotic constriction ring (HP:0009775)2.07067229
107Abnormality of placental membranes (HP:0011409)2.07067229
108Chest pain (HP:0100749)2.06956167
109Loss of speech (HP:0002371)2.06938612
110Osteolytic defects of the hand bones (HP:0009699)2.06174185
111Osteolytic defects of the phalanges of the hand (HP:0009771)2.06174185
112Reduced subcutaneous adipose tissue (HP:0003758)2.05492522
113Bulbar palsy (HP:0001283)2.05410706
114EMG: neuropathic changes (HP:0003445)2.04816790
115Short nail (HP:0001799)2.04564774
116Mucopolysacchariduria (HP:0008155)2.03409860
117Urinary glycosaminoglycan excretion (HP:0003541)2.03409860
118Colitis (HP:0002583)2.02855275
119Atrioventricular block (HP:0001678)2.01716142
120Prominent nose (HP:0000448)2.01526764
121Pseudobulbar signs (HP:0002200)2.00941066
122Abnormal atrioventricular conduction (HP:0005150)2.00805844
123Abnormality of pyrimidine metabolism (HP:0004353)2.00436589
124Axonal loss (HP:0003447)2.00395273
125Myoglobinuria (HP:0002913)2.00342864
126Atrophy/Degeneration involving motor neurons (HP:0007373)1.98499458
127Spinal muscular atrophy (HP:0007269)1.98392037
128Recurrent bacterial skin infections (HP:0005406)1.97853920
129J-shaped sella turcica (HP:0002680)1.97778726
130Gonadal dysgenesis (HP:0000133)1.97610186
131Myocardial infarction (HP:0001658)1.96008272
132Basal cell carcinoma (HP:0002671)1.95529950
133Absent forearm bone (HP:0003953)1.95376159
134Aplasia involving forearm bones (HP:0009822)1.95376159
135Exercise-induced myalgia (HP:0003738)1.95096879
136Male pseudohermaphroditism (HP:0000037)1.94594818
137Shawl scrotum (HP:0000049)1.94569438
138Thrombocytosis (HP:0001894)1.94522629
139Embryonal renal neoplasm (HP:0011794)1.93840909
140Prolonged neonatal jaundice (HP:0006579)1.92364178
141Obstructive lung disease (HP:0006536)1.91557556
142Chronic obstructive pulmonary disease (HP:0006510)1.91557556
143Agnosia (HP:0010524)1.90487754
144Cellulitis (HP:0100658)1.89418516
145Abnormality of the nasal mucosa (HP:0000433)1.87935447
146Short ribs (HP:0000773)1.87351614
147Vertebral compression fractures (HP:0002953)1.86950250
148Abnormality of the duodenum (HP:0002246)1.85962440
149Distal upper limb amyotrophy (HP:0007149)1.84816437
150Upper limb amyotrophy (HP:0009129)1.84816437
151Increased intramyocellular lipid droplets (HP:0012240)1.84461678
152Facial cleft (HP:0002006)1.84408720
153Increased nuchal translucency (HP:0010880)1.83671165
154Aplasia/Hypoplasia of the fibula (HP:0006492)1.82930119
155Recurrent abscess formation (HP:0002722)1.82345807
156Carpal bone hypoplasia (HP:0001498)1.82160575
157Flat occiput (HP:0005469)1.82049235
158Abnormal lung lobation (HP:0002101)1.81711346
159Cholelithiasis (HP:0001081)1.80810038
160Papillary thyroid carcinoma (HP:0002895)1.80550516
161Cafe-au-lait spot (HP:0000957)1.80404496
162Abnormality of the carotid arteries (HP:0005344)1.79891956
163Abnormal protein glycosylation (HP:0012346)1.79080222
164Abnormal glycosylation (HP:0012345)1.79080222
165Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79080222
166Abnormal protein N-linked glycosylation (HP:0012347)1.79080222
167Abnormal trabecular bone morphology (HP:0100671)1.79044056
168Broad alveolar ridges (HP:0000187)1.78640432
169Squamous cell carcinoma (HP:0002860)1.78340747
170Diaphragmatic weakness (HP:0009113)1.77644207
171Biliary tract neoplasm (HP:0100574)1.77411267
172Breast hypoplasia (HP:0003187)1.76666736
173Thoracic kyphosis (HP:0002942)1.76378523
174Abnormal delayed hypersensitivity skin test (HP:0002963)1.75992331
175Abnormality of the intrinsic pathway (HP:0010989)1.75427759
176Abnormality of the prostate (HP:0008775)1.74812335
177Median cleft lip (HP:0000161)1.74370416
178Autoimmune thrombocytopenia (HP:0001973)1.74108277
179Abnormality of the thoracic spine (HP:0100711)1.73749832
180Abnormality of the musculature of the hand (HP:0001421)1.73055259
181Rectovaginal fistula (HP:0000143)1.73044726
182Rectal fistula (HP:0100590)1.73044726
183Paralysis (HP:0003470)1.72494874
184Microglossia (HP:0000171)1.72349101
185Increased serum ferritin (HP:0003281)1.71521517
186Hypertriglyceridemia (HP:0002155)1.71299461
187Reduced antithrombin III activity (HP:0001976)1.70692340
188Abnormality of T cell physiology (HP:0011840)1.70535892
189Meningitis (HP:0001287)1.70366018
190Rough bone trabeculation (HP:0100670)1.70183206
191Global brain atrophy (HP:0002283)1.70112837
192Recurrent fungal infections (HP:0002841)1.69461195
193Generalized amyotrophy (HP:0003700)1.69134778
194Abnormality of skeletal muscle fiber size (HP:0012084)1.68781329
195Facial diplegia (HP:0001349)1.67576724
196Abnormal platelet function (HP:0011869)1.65952525
197Impaired platelet aggregation (HP:0003540)1.65952525

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.75715719
2PDK45.06051135
3PDK35.06051135
4TESK24.26449885
5CDC74.13048800
6NME23.88020212
7ERN13.47180718
8PDK23.15668481
9NEK23.10912848
10ICK2.94290693
11WEE12.85205052
12ACVR1B2.83863291
13SMG12.63847376
14MST1R2.56424662
15ARAF2.35049881
16IRAK32.32086373
17VRK22.32080698
18TTK2.25701990
19BUB12.23643862
20PRKD32.16323483
21BRD42.10487197
22PRPF4B2.08290025
23MAP2K32.03133594
24PNCK1.96208629
25MAP3K141.89169700
26PIM21.87581283
27TBK11.86327263
28TYRO31.84197619
29TAOK21.84008209
30PLK11.79944195
31TRIB31.76817024
32TTN1.75772549
33MOS1.69701816
34ATR1.67886249
35CDK71.64827207
36MAPK111.63068508
37NEK91.60185310
38TESK11.56550061
39EPHA21.56043272
40CHEK11.48246637
41TXK1.37983222
42MAP3K41.37207932
43CHEK21.33213950
44CDK191.30793625
45PASK1.30789224
46MAP3K131.25233597
47LIMK11.23342417
48NEK11.21932366
49MAP3K101.21294997
50SIK11.19469354
51CDK41.17260489
52TSSK61.17225719
53ATM1.16245575
54MAP4K11.14044168
55MTOR1.12079638
56DAPK11.11496688
57AKT31.07929386
58MAPK151.04751867
59MATK1.02990925
60MAP3K31.02605317
61ZAP701.00278343
62GRK70.97747518
63EEF2K0.96211202
64ABL20.92284535
65PLK40.91747683
66CDK20.91590689
67PTK2B0.91039360
68KDR0.88796649
69TRPM70.87735249
70STK30.87406152
71MAP2K60.87350459
72MAPKAPK30.87251468
73IKBKB0.85927440
74TGFBR20.85888343
75PBK0.84617584
76SRPK10.84029053
77BLK0.83918469
78AURKB0.83019588
79MAP3K110.81563661
80WNK10.81230100
81BRSK20.81073466
82RPS6KB20.80829475
83AURKA0.79426007
84EPHB10.75470978
85STK160.75244234
86CSF1R0.74712422
87CDK10.72351982
88STK38L0.71501960
89PLK30.69959778
90PAK40.69877466
91CCNB10.69485891
92DYRK30.68689124
93NTRK10.67651026
94JAK30.67277286
95WNK30.65207445
96TYK20.64345365
97MAPKAPK20.63318509
98MST40.62803597
99PDPK10.61808977
100CAMK1D0.59535968
101PTK20.59218413
102STK40.58283039
103CSNK1E0.57293763
104PRKD20.56986324
105GRK60.54257967
106STK380.54236514
107CDK90.52538424
108TAOK30.51975427
109MAP3K10.51882191
110HIPK20.51160963
111BTK0.51155279
112CSNK1D0.51061928
113CDC42BPA0.50801936
114SCYL20.50748486
115RIPK10.50668954
116MAPK120.49382766
117CSNK2A20.49301128
118PRKDC0.48924155
119CSK0.48665424
120BRSK10.46907846
121MET0.46846513
122MELK0.45908311
123GSK3B0.44373776
124ALK0.43946402
125IKBKE0.42657156
126KIT0.42324279
127CAMK1G0.42272199
128FLT30.42094661
129DYRK1B0.41345349
130RPS6KC10.41214849
131RPS6KL10.41214849
132RIPK40.41163187
133PIM10.39057565
134SIK30.39036685
135RET0.39020163
136WNK40.38803634
137EIF2AK10.37889916
138MAPK140.36369406
139STK100.35774512
140LRRK20.35692970
141BMX0.35531730
142RAF10.35266015
143PDK10.34585453
144MAP3K80.34511612
145RPS6KB10.33901173
146ITK0.33811571
147CAMKK20.33234140
148CDK60.32307906
149PAK10.31964427
150LATS20.31510476
151CSNK2A10.31497757
152TLK10.31445553
153TGFBR10.31046951
154MAPK10.30947566
155MAPK80.30811870
156GRK50.30094375
157PDGFRA0.29998650
158MKNK20.26602835
159PRKAA10.26078797
160BCKDK0.23823364
161MAPK100.23801747
162PKN20.22426002
163RPS6KA10.21493625
164PRKCI0.21058170
165AKT10.21047036
166ERBB40.19331778
167MAP3K60.18965381
168BRAF0.18802985
169PAK20.18074404

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.20735946
2Mismatch repair_Homo sapiens_hsa034303.65819233
3DNA replication_Homo sapiens_hsa030303.51467040
4RNA transport_Homo sapiens_hsa030133.34682633
5Basal transcription factors_Homo sapiens_hsa030223.10420938
6Other glycan degradation_Homo sapiens_hsa005113.01670037
7Homologous recombination_Homo sapiens_hsa034403.00118135
8Caffeine metabolism_Homo sapiens_hsa002322.94460256
9Sulfur relay system_Homo sapiens_hsa041222.88634007
10Fanconi anemia pathway_Homo sapiens_hsa034602.87593253
11Vitamin B6 metabolism_Homo sapiens_hsa007502.73506098
12mRNA surveillance pathway_Homo sapiens_hsa030152.62262371
13One carbon pool by folate_Homo sapiens_hsa006702.57455286
14Selenocompound metabolism_Homo sapiens_hsa004502.53148016
15Spliceosome_Homo sapiens_hsa030402.48097298
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.47163296
17Nucleotide excision repair_Homo sapiens_hsa034202.43500333
18Glycosaminoglycan degradation_Homo sapiens_hsa005312.41942387
19Cell cycle_Homo sapiens_hsa041102.36366635
20Base excision repair_Homo sapiens_hsa034102.34642476
21Galactose metabolism_Homo sapiens_hsa000522.20484414
22Lysosome_Homo sapiens_hsa041422.11748468
23Dorso-ventral axis formation_Homo sapiens_hsa043202.02885146
24Allograft rejection_Homo sapiens_hsa053302.00282382
25Primary immunodeficiency_Homo sapiens_hsa053401.98478766
26Autoimmune thyroid disease_Homo sapiens_hsa053201.94066233
27Proteasome_Homo sapiens_hsa030501.89201182
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.88370791
29Non-homologous end-joining_Homo sapiens_hsa034501.85433674
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77118144
31Pyruvate metabolism_Homo sapiens_hsa006201.75263757
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.74045533
33Oocyte meiosis_Homo sapiens_hsa041141.73694686
34Viral myocarditis_Homo sapiens_hsa054161.64762053
35Pentose phosphate pathway_Homo sapiens_hsa000301.62614466
36Graft-versus-host disease_Homo sapiens_hsa053321.59588413
37RNA polymerase_Homo sapiens_hsa030201.59377061
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57180954
39Biosynthesis of amino acids_Homo sapiens_hsa012301.51340628
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.50783277
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.49687511
42RNA degradation_Homo sapiens_hsa030181.46830170
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.46727093
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45075187
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41086343
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.40595338
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37013663
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36921562
49Asthma_Homo sapiens_hsa053101.30773786
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.30521896
51Apoptosis_Homo sapiens_hsa042101.29113811
52Acute myeloid leukemia_Homo sapiens_hsa052211.28328078
53Leishmaniasis_Homo sapiens_hsa051401.28315670
54Lysine degradation_Homo sapiens_hsa003101.27275962
55Fatty acid biosynthesis_Homo sapiens_hsa000611.25349051
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24195484
57Linoleic acid metabolism_Homo sapiens_hsa005911.22883043
58Shigellosis_Homo sapiens_hsa051311.20464686
59Toxoplasmosis_Homo sapiens_hsa051451.18890965
60Influenza A_Homo sapiens_hsa051641.16570497
61Rheumatoid arthritis_Homo sapiens_hsa053231.14607982
62Tuberculosis_Homo sapiens_hsa051521.14391752
63Pyrimidine metabolism_Homo sapiens_hsa002401.13690886
64Fructose and mannose metabolism_Homo sapiens_hsa000511.12810349
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12199260
66N-Glycan biosynthesis_Homo sapiens_hsa005101.10573327
67Carbon metabolism_Homo sapiens_hsa012001.09910248
68Hematopoietic cell lineage_Homo sapiens_hsa046401.06726664
69Osteoclast differentiation_Homo sapiens_hsa043801.05498074
70B cell receptor signaling pathway_Homo sapiens_hsa046621.02124059
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00992857
72Chronic myeloid leukemia_Homo sapiens_hsa052200.98235442
73Measles_Homo sapiens_hsa051620.97011380
74Endocytosis_Homo sapiens_hsa041440.93023650
75Type I diabetes mellitus_Homo sapiens_hsa049400.91811568
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91636341
77Salmonella infection_Homo sapiens_hsa051320.91245200
78Pancreatic cancer_Homo sapiens_hsa052120.90648655
79Phagosome_Homo sapiens_hsa041450.89409034
80TNF signaling pathway_Homo sapiens_hsa046680.89359975
81p53 signaling pathway_Homo sapiens_hsa041150.88062090
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87715577
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.86519780
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86436223
85Glucagon signaling pathway_Homo sapiens_hsa049220.84922679
86Hepatitis B_Homo sapiens_hsa051610.82986332
87VEGF signaling pathway_Homo sapiens_hsa043700.80264703
88Tyrosine metabolism_Homo sapiens_hsa003500.79294564
89Propanoate metabolism_Homo sapiens_hsa006400.78437749
90Sulfur metabolism_Homo sapiens_hsa009200.76188961
91Staphylococcus aureus infection_Homo sapiens_hsa051500.74769918
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.73661567
93Pertussis_Homo sapiens_hsa051330.72900622
94Purine metabolism_Homo sapiens_hsa002300.72464436
95Fatty acid metabolism_Homo sapiens_hsa012120.72201100
96Hepatitis C_Homo sapiens_hsa051600.71903899
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71634843
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71030204
99Epstein-Barr virus infection_Homo sapiens_hsa051690.70963854
100Tryptophan metabolism_Homo sapiens_hsa003800.69883563
101Bladder cancer_Homo sapiens_hsa052190.69844676
102Phenylalanine metabolism_Homo sapiens_hsa003600.69457015
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69200181
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68022054
105Prolactin signaling pathway_Homo sapiens_hsa049170.66798522
106Antigen processing and presentation_Homo sapiens_hsa046120.64196929
107Viral carcinogenesis_Homo sapiens_hsa052030.60858940
108Legionellosis_Homo sapiens_hsa051340.58212550
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56603227
110T cell receptor signaling pathway_Homo sapiens_hsa046600.55529331
111Herpes simplex infection_Homo sapiens_hsa051680.54554470
112Systemic lupus erythematosus_Homo sapiens_hsa053220.54101625
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53019715
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52609747
115Non-small cell lung cancer_Homo sapiens_hsa052230.52383039
116Histidine metabolism_Homo sapiens_hsa003400.51813682
117TGF-beta signaling pathway_Homo sapiens_hsa043500.51810686
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51719108
119Small cell lung cancer_Homo sapiens_hsa052220.51366407
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51289975
121Folate biosynthesis_Homo sapiens_hsa007900.51158923
122Thyroid cancer_Homo sapiens_hsa052160.50886688
123HTLV-I infection_Homo sapiens_hsa051660.49906280
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48097342
125Fatty acid elongation_Homo sapiens_hsa000620.47558289
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46711569
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46678229
128Glutathione metabolism_Homo sapiens_hsa004800.46501268
129Notch signaling pathway_Homo sapiens_hsa043300.46283676
130Inositol phosphate metabolism_Homo sapiens_hsa005620.45862185
131Fatty acid degradation_Homo sapiens_hsa000710.45625590
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.44616313
133* Glycerophospholipid metabolism_Homo sapiens_hsa005640.44461124
134Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43104605
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42857863
136Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41714059
137PPAR signaling pathway_Homo sapiens_hsa033200.41466612
138Hippo signaling pathway_Homo sapiens_hsa043900.41354639
139Hedgehog signaling pathway_Homo sapiens_hsa043400.40324833
140Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40194472
141Malaria_Homo sapiens_hsa051440.39590425
142Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39462032
143* Glycerolipid metabolism_Homo sapiens_hsa005610.39397407
144Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38873957
145Fat digestion and absorption_Homo sapiens_hsa049750.38284101
146Leukocyte transendothelial migration_Homo sapiens_hsa046700.38117331
147mTOR signaling pathway_Homo sapiens_hsa041500.37863104
148Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37588351
149Arginine biosynthesis_Homo sapiens_hsa002200.37071366
150Huntingtons disease_Homo sapiens_hsa050160.36554657
151Ribosome_Homo sapiens_hsa030100.36183983
152Basal cell carcinoma_Homo sapiens_hsa052170.35911256
153Drug metabolism - other enzymes_Homo sapiens_hsa009830.33186936
154Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32752878
155Primary bile acid biosynthesis_Homo sapiens_hsa001200.31995456
156MicroRNAs in cancer_Homo sapiens_hsa052060.31935440
157Arginine and proline metabolism_Homo sapiens_hsa003300.31619144
158Bile secretion_Homo sapiens_hsa049760.31008896
159Alcoholism_Homo sapiens_hsa050340.30425317
160Nitrogen metabolism_Homo sapiens_hsa009100.30132876
161Complement and coagulation cascades_Homo sapiens_hsa046100.29444193
162Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29060447
163Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27581800
164Chemical carcinogenesis_Homo sapiens_hsa052040.27497486
165AMPK signaling pathway_Homo sapiens_hsa041520.26936167
166Tight junction_Homo sapiens_hsa045300.23102048
167Vitamin digestion and absorption_Homo sapiens_hsa049770.21487717
168ABC transporters_Homo sapiens_hsa020100.18786474
169* Metabolic pathways_Homo sapiens_hsa011000.17938530
170Adherens junction_Homo sapiens_hsa045200.17860227

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