GPAT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the lysophosphatidic acid acyltransferase protein family. The encoded protein is an enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)4.94474329
2modulation by symbiont of host defense response (GO:0052031)4.94474329
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.94474329
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.94474329
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.94474329
6modulation by symbiont of host immune response (GO:0052553)4.94474329
7detection of molecule of bacterial origin (GO:0032490)4.87803967
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.78153103
9neutrophil activation involved in immune response (GO:0002283)4.72036227
10detection of other organism (GO:0098543)4.38667011
11response to peptidoglycan (GO:0032494)4.37409682
12macrophage activation involved in immune response (GO:0002281)4.34926789
13detection of external biotic stimulus (GO:0098581)4.29536663
14regulation of interferon-beta biosynthetic process (GO:0045357)4.20167904
15positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.15789138
16positive regulation of gamma-delta T cell activation (GO:0046645)4.00600646
17detection of bacterium (GO:0016045)3.94000154
18negative regulation of cell killing (GO:0031342)3.77838747
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.77838747
20cellular extravasation (GO:0045123)3.77771994
21detection of biotic stimulus (GO:0009595)3.70615979
22positive regulation of mast cell activation (GO:0033005)3.63359170
23immunoglobulin mediated immune response (GO:0016064)3.58598384
24negative regulation of interleukin-12 production (GO:0032695)3.54264639
25neutrophil activation (GO:0042119)3.47841303
26antigen processing and presentation of endogenous antigen (GO:0019883)3.43882233
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.41716283
28positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.39543432
29macrophage activation (GO:0042116)3.39508617
30regulation of B cell receptor signaling pathway (GO:0050855)3.38983896
31lipopolysaccharide-mediated signaling pathway (GO:0031663)3.38867316
32regulation of mast cell degranulation (GO:0043304)3.36127174
33granulocyte activation (GO:0036230)3.35877621
34microglial cell activation (GO:0001774)3.35829712
35response to host immune response (GO:0052572)3.32600046
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.32600046
37positive regulation of leukocyte degranulation (GO:0043302)3.31077300
38response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.28324875
39response to host (GO:0075136)3.28324875
40response to host defenses (GO:0052200)3.28324875
41glycosphingolipid catabolic process (GO:0046479)3.22384303
42positive regulation of mast cell degranulation (GO:0043306)3.21902049
43positive regulation of mast cell activation involved in immune response (GO:0033008)3.21902049
44regulation of mast cell activation involved in immune response (GO:0033006)3.13690495
45regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.12858248
46regulation of necroptotic process (GO:0060544)3.11044888
47oligosaccharide catabolic process (GO:0009313)3.09520713
48positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.08810134
49regulation of leukocyte degranulation (GO:0043300)3.08382707
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.07609532
51T-helper 1 type immune response (GO:0042088)3.07185685
52neutrophil mediated immunity (GO:0002446)3.06334816
53myeloid cell activation involved in immune response (GO:0002275)3.05948119
54production of molecular mediator involved in inflammatory response (GO:0002532)3.04589234
55regulation of mast cell activation (GO:0033003)2.99623968
56glycolipid catabolic process (GO:0019377)2.99304090
57respiratory burst (GO:0045730)2.99128594
58regulation of gamma-delta T cell activation (GO:0046643)2.97991837
59regulation of myeloid leukocyte mediated immunity (GO:0002886)2.97694467
60regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.94688969
61germinal center formation (GO:0002467)2.91101012
62interferon-gamma-mediated signaling pathway (GO:0060333)2.90374315
63hypotonic response (GO:0006971)2.90054705
64negative regulation of necroptotic process (GO:0060546)2.89576575
65cellular response to thyroid hormone stimulus (GO:0097067)2.85596008
66negative regulation of interleukin-17 production (GO:0032700)2.84977250
67B cell mediated immunity (GO:0019724)2.83313256
68positive regulation of toll-like receptor signaling pathway (GO:0034123)2.81384883
69leukocyte aggregation (GO:0070486)2.81028624
70positive regulation of cellular amide metabolic process (GO:0034250)2.80334480
71positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.79378718
72regulation of gamma-delta T cell differentiation (GO:0045586)2.77741982
73positive regulation of interferon-alpha production (GO:0032727)2.74657448
74regulation of necrotic cell death (GO:0010939)2.72250796
75positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.69506659
76membrane raft organization (GO:0031579)2.65065436
77positive regulation of regulated secretory pathway (GO:1903307)2.64531148
78antigen processing and presentation via MHC class Ib (GO:0002475)2.64130198
79regulation of platelet aggregation (GO:0090330)2.63216371
80protein localization to endosome (GO:0036010)2.56225182
81regulation of interferon-alpha production (GO:0032647)2.55302697
82ceramide catabolic process (GO:0046514)2.54001565
83regulation of T-helper 2 cell differentiation (GO:0045628)2.53509588
84myeloid leukocyte activation (GO:0002274)2.49792554
85regulation of superoxide anion generation (GO:0032928)2.48888020
86regulation of interleukin-17 production (GO:0032660)2.47159883
87positive regulation of interleukin-6 production (GO:0032755)2.46295915
88neutrophil chemotaxis (GO:0030593)2.45763768
89hepatocyte apoptotic process (GO:0097284)2.45433814
90dendritic cell migration (GO:0036336)2.45057256
91positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.44972594
92I-kappaB phosphorylation (GO:0007252)2.44494218
93regulation of regulated secretory pathway (GO:1903305)2.43447028
94positive regulation of Cdc42 GTPase activity (GO:0043089)2.43336492
95neutrophil migration (GO:1990266)2.42657579
96positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.39266190
97positive regulation of interferon-beta production (GO:0032728)2.38521091
98leukocyte migration involved in inflammatory response (GO:0002523)2.37408619
99response to thyroid hormone (GO:0097066)2.36770937
100pinocytosis (GO:0006907)2.36613579

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.84483986
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.01795506
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.54825783
4MYB_21317192_ChIP-Seq_ERMYB_Mouse3.41891341
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.40448041
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.24968257
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.10351453
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.10335246
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.02969281
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.99578270
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.67276883
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.66999049
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.63225231
14SPI1_23547873_ChIP-Seq_NB4_Human2.43319647
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.41363691
16BRD4_27068464_Chip-Seq_AML-cells_Mouse2.28532068
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.23754616
18SPI1_23127762_ChIP-Seq_K562_Human2.20891628
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.18879850
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.17438970
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.07136320
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.97767322
23SCL_19346495_ChIP-Seq_HPC-7_Human1.97699173
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.96377241
25RUNX1_22412390_ChIP-Seq_EML_Mouse1.89359050
26RUNX_20019798_ChIP-Seq_JUKART_Human1.86233425
27MYB_26560356_Chip-Seq_TH2_Human1.85815882
28VDR_24763502_ChIP-Seq_THP-1_Human1.85330583
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81279673
30VDR_24787735_ChIP-Seq_THP-1_Human1.79269796
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.78174362
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.76503999
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69797243
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69740183
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.64429273
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60400103
37GATA1_22025678_ChIP-Seq_K562_Human1.53114896
38CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50943849
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50707579
40MAF_26560356_Chip-Seq_TH1_Human1.49500196
41MYB_26560356_Chip-Seq_TH1_Human1.47917802
42GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38930642
43SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36951896
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36951896
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36495252
46ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.36418728
47PU_27001747_Chip-Seq_BMDM_Mouse1.35698261
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35601575
49TFEB_21752829_ChIP-Seq_HELA_Human1.34801263
50VDR_21846776_ChIP-Seq_THP-1_Human1.34181516
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33193998
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31562245
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30383542
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.29171229
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26349464
56CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26158454
57PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25910622
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25532085
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24967094
60GATA3_27048872_Chip-Seq_THYMUS_Human1.24814758
61RXR_22158963_ChIP-Seq_LIVER_Mouse1.23332989
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20983370
63PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.20679627
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.19152826
65SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18893427
66TCF7_22412390_ChIP-Seq_EML_Mouse1.18826622
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17712343
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17166079
69CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17030066
70LXR_22158963_ChIP-Seq_LIVER_Mouse1.16817731
71JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16346440
72SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16188944
73PPARA_22158963_ChIP-Seq_LIVER_Mouse1.14602129
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14443322
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13607716
76FOXO3_23340844_ChIP-Seq_DLD1_Human1.13156139
77SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12977319
78FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12786705
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12179185
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11495913
81FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11351273
82GATA2_19941826_ChIP-Seq_K562_Human1.11098093
83JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11003691
84GATA3_26560356_Chip-Seq_TH2_Human1.10551559
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10317574
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09844009
87GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08067880
88UTX_26944678_Chip-Seq_JUKART_Human1.08013231
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07558492
90ELK3_25401928_ChIP-Seq_HUVEC_Human1.05142769
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04731001
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03905412
93ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03551215
94GATA1_19941826_ChIP-Seq_K562_Human1.02681870
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01519950
96ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99338851
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97347277
98ATF3_27146783_Chip-Seq_COLON_Human0.97040294
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96206517
100CLOCK_20551151_ChIP-Seq_293T_Human0.96053035

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.52214397
2MP0005451_abnormal_body_composition3.25103019
3MP0003436_decreased_susceptibility_to3.02042132
4MP0003191_abnormal_cellular_cholesterol2.99374491
5MP0001835_abnormal_antigen_presentation2.71095268
6MP0002419_abnormal_innate_immunity2.49654437
7MP0003303_peritoneal_inflammation2.49021001
8MP0003828_pulmonary_edema2.44911376
9MP0002877_abnormal_melanocyte_morpholog2.34868198
10MP0003300_gastrointestinal_ulcer2.23647849
11MP0009785_altered_susceptibility_to2.19936309
12MP0002148_abnormal_hypersensitivity_rea2.12606540
13MP0003806_abnormal_nucleotide_metabolis2.08251556
14MP0006082_CNS_inflammation2.05564976
15MP0009840_abnormal_foam_cell2.00048784
16MP0005025_abnormal_response_to1.98065959
17MP0005000_abnormal_immune_tolerance1.93100364
18MP0008260_abnormal_autophagy1.87964228
19MP0005671_abnormal_response_to1.86678351
20MP0002452_abnormal_antigen_presenting1.84727051
21MP0004510_myositis1.83157376
22MP0005464_abnormal_platelet_physiology1.81428093
23MP0002723_abnormal_immune_serum1.76518189
24MP0003656_abnormal_erythrocyte_physiolo1.74667417
25MP0005058_abnormal_lysosome_morphology1.74488498
26MP0001800_abnormal_humoral_immune1.72096988
27MP0002420_abnormal_adaptive_immunity1.65222186
28MP0001819_abnormal_immune_cell1.64449513
29MP0005387_immune_system_phenotype1.63977508
30MP0001790_abnormal_immune_system1.63977508
31MP0010155_abnormal_intestine_physiology1.63499916
32MP0004947_skin_inflammation1.62352422
33MP0003075_altered_response_to1.60920148
34MP0000685_abnormal_immune_system1.60808460
35MP0000343_altered_response_to1.56501078
36MP0005166_decreased_susceptibility_to1.56287071
37MP0001533_abnormal_skeleton_physiology1.56264713
38MP0009333_abnormal_splenocyte_physiolog1.54745884
39MP0010234_abnormal_vibrissa_follicle1.53956032
40MP0001845_abnormal_inflammatory_respons1.53476109
41MP0002332_abnormal_exercise_endurance1.49334569
42MP0000858_altered_metastatic_potential1.48050174
43MP0008469_abnormal_protein_level1.41281405
44MP0003172_abnormal_lysosome_physiology1.40672386
45MP0002139_abnormal_hepatobiliary_system1.38282131
46MP0002998_abnormal_bone_remodeling1.37636891
47MP0005164_abnormal_response_to1.36201575
48MP0002405_respiratory_system_inflammati1.32885205
49MP0004484_altered_response_of1.32754329
50MP0009764_decreased_sensitivity_to1.32148934
51MP0001853_heart_inflammation1.22891974
52MP0000465_gastrointestinal_hemorrhage1.19748384
53MP0005165_increased_susceptibility_to1.18124360
54MP0004036_abnormal_muscle_relaxation1.17510891
55MP0005397_hematopoietic_system_phenotyp1.17458730
56MP0001545_abnormal_hematopoietic_system1.17458730
57MP0004084_abnormal_cardiac_muscle1.16750332
58MP0002132_abnormal_respiratory_system1.16579302
59MP0000716_abnormal_immune_system1.15154855
60MP0003646_muscle_fatigue1.14598212
61MP0005360_urolithiasis1.13228865
62MP0002398_abnormal_bone_marrow1.11932248
63MP0008004_abnormal_stomach_pH1.11584906
64MP0003866_abnormal_defecation1.10016305
65MP0003763_abnormal_thymus_physiology1.09745716
66MP0000604_amyloidosis1.08552722
67MP0005085_abnormal_gallbladder_physiolo1.04511798
68MP0000749_muscle_degeneration1.00613246
69MP0002166_altered_tumor_susceptibility0.99738999
70MP0003045_fibrosis0.98777282
71MP0003448_altered_tumor_morphology0.98569358
72MP0004185_abnormal_adipocyte_glucose0.97365669
73MP0002429_abnormal_blood_cell0.96862364
74MP0000689_abnormal_spleen_morphology0.96145321
75MP0004808_abnormal_hematopoietic_stem0.95855816
76MP0002722_abnormal_immune_system0.94777361
77MP0003221_abnormal_cardiomyocyte_apopto0.92885036
78MP0009763_increased_sensitivity_to0.90369679
79MP0004233_abnormal_muscle_weight0.89905016
80MP0000747_muscle_weakness0.89742226
81MP0002396_abnormal_hematopoietic_system0.89654936
82MP0003183_abnormal_peptide_metabolism0.89594589
83MP0005330_cardiomyopathy0.89380566
84MP0005319_abnormal_enzyme/_coenzyme0.88871660
85MP0003453_abnormal_keratinocyte_physiol0.88457382
86MP0004883_abnormal_blood_vessel0.88017182
87MP0005666_abnormal_adipose_tissue0.87779251
88MP0004130_abnormal_muscle_cell0.87069460
89MP0002006_tumorigenesis0.86277635
90MP0000609_abnormal_liver_physiology0.82770203
91MP0002269_muscular_atrophy0.82262328
92MP0003091_abnormal_cell_migration0.81289410
93MP0005376_homeostasis/metabolism_phenot0.80369043
94MP0001851_eye_inflammation0.80322198
95MP0005365_abnormal_bile_salt0.79316054
96MP0010352_gastrointestinal_tract_polyps0.77373275
97MP0003566_abnormal_cell_adhesion0.77336825
98MP0002972_abnormal_cardiac_muscle0.77214365
99MP0002971_abnormal_brown_adipose0.77123360
100MP0006036_abnormal_mitochondrial_physio0.77068154

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.00222608
2Recurrent bacterial skin infections (HP:0005406)4.49286151
3Recurrent abscess formation (HP:0002722)4.48681237
4Abnormality of macrophages (HP:0004311)4.43826721
5Recurrent gram-negative bacterial infections (HP:0005420)3.80045159
6Abnormality of glycolipid metabolism (HP:0010969)3.63096645
7Abnormality of liposaccharide metabolism (HP:0010968)3.63096645
8Abnormality of glycosphingolipid metabolism (HP:0004343)3.63096645
9Myositis (HP:0100614)3.56500231
10Orchitis (HP:0100796)3.42480405
11Fatigue (HP:0012378)3.35041318
12Myocardial infarction (HP:0001658)3.33934926
13Elevated erythrocyte sedimentation rate (HP:0003565)3.22695178
14Stomatitis (HP:0010280)3.22686575
15Mediastinal lymphadenopathy (HP:0100721)3.15685328
16Gastrointestinal infarctions (HP:0005244)3.05639341
17Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.01898502
18Muscle fiber inclusion bodies (HP:0100299)3.01293727
19Retrobulbar optic neuritis (HP:0100654)2.95041407
20Optic neuritis (HP:0100653)2.95041407
21Amyloidosis (HP:0011034)2.95038724
22Obstructive lung disease (HP:0006536)2.94807084
23Chronic obstructive pulmonary disease (HP:0006510)2.94807084
24Nemaline bodies (HP:0003798)2.93746647
25Distal lower limb muscle weakness (HP:0009053)2.92622293
26Chest pain (HP:0100749)2.90203215
27Recurrent skin infections (HP:0001581)2.82632873
28Urticaria (HP:0001025)2.82467214
29Gingivitis (HP:0000230)2.76708666
30Vacuolated lymphocytes (HP:0001922)2.72622922
31Increased cerebral lipofuscin (HP:0011813)2.62778155
32Arterial thrombosis (HP:0004420)2.58534757
33EMG: myopathic abnormalities (HP:0003458)2.52031733
34Asymmetric septal hypertrophy (HP:0001670)2.50109090
35Recurrent fungal infections (HP:0002841)2.49118141
36Increased connective tissue (HP:0009025)2.47361984
37Distal lower limb amyotrophy (HP:0008944)2.44948959
38Muscle fiber splitting (HP:0003555)2.39401738
39Loss of speech (HP:0002371)2.39261395
40Centrally nucleated skeletal muscle fibers (HP:0003687)2.29786954
41Gingival bleeding (HP:0000225)2.28265327
42Meningitis (HP:0001287)2.25948173
43Vasculitis (HP:0002633)2.23952668
44Osteomyelitis (HP:0002754)2.23689584
45Spontaneous hematomas (HP:0007420)2.20679385
46Exercise-induced myalgia (HP:0003738)2.19424911
47Rhabdomyolysis (HP:0003201)2.15867315
48T lymphocytopenia (HP:0005403)2.15659352
49Hepatosplenomegaly (HP:0001433)2.13757794
50Keratoconjunctivitis sicca (HP:0001097)2.13112400
51Pulmonary infiltrates (HP:0002113)2.12883810
52Recurrent cutaneous fungal infections (HP:0011370)2.12702041
53Chronic mucocutaneous candidiasis (HP:0002728)2.12702041
54Hyporeflexia of lower limbs (HP:0002600)2.09084918
55Abnormality of T cell number (HP:0011839)2.09006634
56Polycythemia (HP:0001901)2.08533753
57Osteolytic defects of the phalanges of the hand (HP:0009771)2.05307618
58Osteolytic defects of the hand bones (HP:0009699)2.05307618
59Acute hepatic failure (HP:0006554)2.04749456
60Chronic diarrhea (HP:0002028)2.03731119
61Increased neuronal autofluorescent lipopigment (HP:0002074)2.03573273
62Pustule (HP:0200039)2.01518963
63Cellulitis (HP:0100658)1.98931899
64Epistaxis (HP:0000421)1.98220049
65Hemoptysis (HP:0002105)1.97884355
66Difficulty running (HP:0009046)1.97280742
67Malnutrition (HP:0004395)1.97253912
68Neck muscle weakness (HP:0000467)1.96815812
69Amaurosis fugax (HP:0100576)1.93397134
70Petechiae (HP:0000967)1.93361020
71Polyneuropathy (HP:0001271)1.92094398
72Anorexia (HP:0002039)1.90483308
73Abnormal delayed hypersensitivity skin test (HP:0002963)1.89854431
74Toxemia of pregnancy (HP:0100603)1.89256921
75Keratoconjunctivitis (HP:0001096)1.88530364
76Reduced subcutaneous adipose tissue (HP:0003758)1.87473255
77Autoimmune thrombocytopenia (HP:0001973)1.85920452
78Subacute progressive viral hepatitis (HP:0006572)1.85292420
79Encephalitis (HP:0002383)1.84490139
80Gangrene (HP:0100758)1.84166215
81Glomerulopathy (HP:0100820)1.83142721
82Increased serum ferritin (HP:0003281)1.82902182
83Increased IgE level (HP:0003212)1.81608949
84Disinhibition (HP:0000734)1.81029433
85Axonal loss (HP:0003447)1.78667890
86Increased CSF protein (HP:0002922)1.76362392
87Thrombocytosis (HP:0001894)1.75865818
88Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.75629580
89Vertigo (HP:0002321)1.74955105
90Vertebral compression fractures (HP:0002953)1.74318389
91Peritonitis (HP:0002586)1.73846704
92Recurrent viral infections (HP:0004429)1.73623321
93Cerebral hemorrhage (HP:0001342)1.73012810
94Dysostosis multiplex (HP:0000943)1.72068242
95Myoglobinuria (HP:0002913)1.71211226
96Leukocytosis (HP:0001974)1.70930341
97Episodic fever (HP:0001954)1.68614589
98Abnormality of the endocardium (HP:0004306)1.67246997
99Upper motor neuron abnormality (HP:0002127)1.66953325
100Tetraparesis (HP:0002273)1.66792336

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK42.84393348
2IRAK32.78281407
3MAP2K32.73327452
4MAP3K132.64899075
5MAP3K32.64431341
6BLK2.48681982
7ERN12.36025390
8MAP3K142.30315990
9CSK2.22160899
10IRAK42.20024957
11TTN2.19357608
12PRPF4B2.10528934
13MST1R2.10013883
14EPHB11.99340683
15ZAP701.87293047
16TYK21.87101846
17EPHA21.83732265
18BMPR21.80269440
19LMTK21.80106912
20MAP3K121.76702491
21MOS1.66236515
22PIK3CG1.65819920
23MAP3K21.60891298
24OBSCN1.57192761
25TAOK31.55671249
26JAK31.55328904
27KSR21.52432831
28TAOK21.52351030
29SIK31.48989110
30STK241.45453234
31TRPM71.43948003
32MAP3K11.40924013
33STK101.40627395
34TBK11.38556710
35PDK21.37427469
36MAP4K11.36996427
37NME21.22327104
38JAK11.19218892
39MST41.19111290
40TGFBR21.14246738
41FGR1.13420085
42GRK61.12195524
43BTK1.08972974
44HCK1.08899726
45PRKG21.08586163
46KSR11.05701073
47PAK41.02579306
48IRAK11.01348827
49TXK1.00612691
50JAK21.00566328
51FES0.95394142
52MARK30.94562128
53PDPK10.93131082
54TAOK10.90181623
55SYK0.89784040
56PDK10.88901548
57IRAK20.87631520
58ARAF0.84760372
59IKBKE0.84640883
60TESK20.82719490
61SCYL20.81585904
62IKBKB0.80875852
63GRK70.79011522
64MAP3K110.78134427
65ERBB40.77970019
66MATK0.76145032
67CSF1R0.75255570
68EIF2AK30.73229359
69RAF10.72213767
70YES10.70138944
71MAP3K60.68986764
72PHKG10.68951133
73PHKG20.68951133
74ITK0.68219031
75MAP3K50.67605950
76PTK60.66467359
77LYN0.65780290
78MAPK120.64528246
79DMPK0.63050219
80LCK0.60629729
81MAP3K80.58614597
82LRRK20.56577194
83TEC0.55259154
84MYLK0.51888180
85ABL20.50321765
86MAPKAPK20.50287339
87FGFR30.49995462
88MAP3K70.49035042
89ERBB30.48000449
90CAMKK20.47796741
91PTK2B0.46577749
92MAP2K60.46068226
93ACVR1B0.45646386
94SGK30.42505892
95MAP3K90.39558837
96PRKAA20.38682197
97NEK90.38488345
98WNK10.37090743
99TESK10.32812580
100MET0.27661516

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.24078535
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.64794804
3Staphylococcus aureus infection_Homo sapiens_hsa051502.59785516
4Graft-versus-host disease_Homo sapiens_hsa053322.58279334
5Allograft rejection_Homo sapiens_hsa053302.54458353
6Osteoclast differentiation_Homo sapiens_hsa043802.51891816
7Autoimmune thyroid disease_Homo sapiens_hsa053202.33435803
8Tuberculosis_Homo sapiens_hsa051522.25379051
9Asthma_Homo sapiens_hsa053102.09188220
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.03025666
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.02270269
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.99920564
13Other glycan degradation_Homo sapiens_hsa005111.97534304
14Viral myocarditis_Homo sapiens_hsa054161.92838436
15Antigen processing and presentation_Homo sapiens_hsa046121.85423611
16Legionellosis_Homo sapiens_hsa051341.84164893
17Type I diabetes mellitus_Homo sapiens_hsa049401.84145190
18Toxoplasmosis_Homo sapiens_hsa051451.83422007
19Phagosome_Homo sapiens_hsa041451.63613024
20Hematopoietic cell lineage_Homo sapiens_hsa046401.63331944
21Rheumatoid arthritis_Homo sapiens_hsa053231.63316251
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.60748613
23Influenza A_Homo sapiens_hsa051641.59552154
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.55810881
25Lysosome_Homo sapiens_hsa041421.51406218
26B cell receptor signaling pathway_Homo sapiens_hsa046621.49291767
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47819263
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.40311605
29Galactose metabolism_Homo sapiens_hsa000521.32709005
30Measles_Homo sapiens_hsa051621.28624154
31Salmonella infection_Homo sapiens_hsa051321.27147306
32TNF signaling pathway_Homo sapiens_hsa046681.23124073
33Malaria_Homo sapiens_hsa051441.22119024
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19558003
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.18828307
36Herpes simplex infection_Homo sapiens_hsa051681.15728391
37Shigellosis_Homo sapiens_hsa051311.15621054
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13906357
39Pentose phosphate pathway_Homo sapiens_hsa000301.12343081
40Chemokine signaling pathway_Homo sapiens_hsa040621.11652835
41Pertussis_Homo sapiens_hsa051331.09218198
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.08370163
43Acute myeloid leukemia_Homo sapiens_hsa052211.07083123
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05053661
45T cell receptor signaling pathway_Homo sapiens_hsa046600.98744934
46Pancreatic cancer_Homo sapiens_hsa052120.98654337
47Adipocytokine signaling pathway_Homo sapiens_hsa049200.97965512
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97624254
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.97434439
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94775443
51Hepatitis C_Homo sapiens_hsa051600.91735028
52Non-small cell lung cancer_Homo sapiens_hsa052230.90285360
53Apoptosis_Homo sapiens_hsa042100.89758416
54Platelet activation_Homo sapiens_hsa046110.86988854
55Hepatitis B_Homo sapiens_hsa051610.84705661
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84295991
57Fructose and mannose metabolism_Homo sapiens_hsa000510.83371776
58Insulin resistance_Homo sapiens_hsa049310.80515526
59Renal cell carcinoma_Homo sapiens_hsa052110.79925286
60Starch and sucrose metabolism_Homo sapiens_hsa005000.78298138
61African trypanosomiasis_Homo sapiens_hsa051430.73206192
62PPAR signaling pathway_Homo sapiens_hsa033200.73044979
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71045700
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68762207
65HIF-1 signaling pathway_Homo sapiens_hsa040660.67534267
66Chronic myeloid leukemia_Homo sapiens_hsa052200.67408478
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65914940
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65597936
69VEGF signaling pathway_Homo sapiens_hsa043700.64864806
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61474730
71Insulin signaling pathway_Homo sapiens_hsa049100.59414825
72Mineral absorption_Homo sapiens_hsa049780.57721310
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56551746
74Amoebiasis_Homo sapiens_hsa051460.54405952
75Bladder cancer_Homo sapiens_hsa052190.54316503
76Fatty acid biosynthesis_Homo sapiens_hsa000610.52993527
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.52219890
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51702560
79Prolactin signaling pathway_Homo sapiens_hsa049170.50931246
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.50280334
81Vitamin digestion and absorption_Homo sapiens_hsa049770.50210290
82Endocytosis_Homo sapiens_hsa041440.49286782
83Epstein-Barr virus infection_Homo sapiens_hsa051690.49000728
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.46643543
85Inositol phosphate metabolism_Homo sapiens_hsa005620.46065143
86mTOR signaling pathway_Homo sapiens_hsa041500.45858851
87Thyroid cancer_Homo sapiens_hsa052160.44719001
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44211708
89Renin-angiotensin system_Homo sapiens_hsa046140.43304733
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43058032
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41105574
92FoxO signaling pathway_Homo sapiens_hsa040680.40394246
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39508629
94Dorso-ventral axis formation_Homo sapiens_hsa043200.36592291
95GnRH signaling pathway_Homo sapiens_hsa049120.34756026
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33408887
97Viral carcinogenesis_Homo sapiens_hsa052030.33038021
98Sphingolipid metabolism_Homo sapiens_hsa006000.32547775
99Primary immunodeficiency_Homo sapiens_hsa053400.31664527
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29523268

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