GPATCH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene encodes a nuclear factor that may play a role in spermatogenesis and in tumor growth during breast cancer. The encoded protein contains a G-patch domain with an RNA binding motif. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoplasmic mRNA processing body assembly (GO:0033962)9.64580359
2regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)8.00213857
3positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)8.00213857
4positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO7.89667465
5regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)7.89667465
6regulation of histone H3-K27 methylation (GO:0061085)6.79944832
7positive regulation of mRNA catabolic process (GO:0061014)6.62607759
8positive regulation of DNA-dependent DNA replication (GO:2000105)6.25615890
9regulation of mRNA catabolic process (GO:0061013)5.92070816
10positive regulation of mRNA 3-end processing (GO:0031442)5.40201293
11N-glycan processing (GO:0006491)5.29122636
12ribosomal small subunit biogenesis (GO:0042274)5.07915097
13regulation of mRNA 3-end processing (GO:0031440)4.84294859
14synaptic vesicle endocytosis (GO:0048488)4.69053506
15presynaptic membrane assembly (GO:0097105)4.61276476
16rRNA methylation (GO:0031167)4.11817310
17protein heterotetramerization (GO:0051290)4.05615679
18positive regulation of mRNA processing (GO:0050685)3.94487610
19behavioral response to nicotine (GO:0035095)3.93178119
20regulation of DNA endoreduplication (GO:0032875)3.88726044
21viral transcription (GO:0019083)3.83515398
22RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.82788872
23maintenance of protein location in nucleus (GO:0051457)3.78634805
24positive regulation of mRNA metabolic process (GO:1903313)3.77518899
25postsynaptic membrane organization (GO:0001941)3.68242543
26interferon-gamma production (GO:0032609)3.65293275
27rRNA modification (GO:0000154)3.64807291
28otic vesicle formation (GO:0030916)3.62947040
29translational termination (GO:0006415)3.62166353
30regulation of stem cell maintenance (GO:2000036)3.59086572
31regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.58337680
32replicative senescence (GO:0090399)3.57828494
33sulfation (GO:0051923)3.52146423
34mature B cell differentiation (GO:0002335)3.48920144
35cilium or flagellum-dependent cell motility (GO:0001539)3.44073078
36protein prenylation (GO:0018342)3.40552596
37prenylation (GO:0097354)3.40552596
38DNA double-strand break processing (GO:0000729)3.38092220
39exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.36964633
40negative regulation of execution phase of apoptosis (GO:1900118)3.36703549
41fusion of sperm to egg plasma membrane (GO:0007342)3.36059610
42water-soluble vitamin biosynthetic process (GO:0042364)3.35102648
43presynaptic membrane organization (GO:0097090)3.34830180
44nonmotile primary cilium assembly (GO:0035058)3.33297403
45negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.31737887
46negative regulation of translation, ncRNA-mediated (GO:0040033)3.31737887
47regulation of translation, ncRNA-mediated (GO:0045974)3.31737887
48positive regulation of developmental pigmentation (GO:0048087)3.29649407
49Golgi to endosome transport (GO:0006895)3.29155169
50RNA localization (GO:0006403)3.27734400
51negative regulation of DNA-dependent DNA replication (GO:2000104)3.27633766
52SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.25692340
53cotranslational protein targeting to membrane (GO:0006613)3.22842141
54cell proliferation in forebrain (GO:0021846)3.18714734
55protein targeting to ER (GO:0045047)3.18480359
56magnesium ion transport (GO:0015693)3.17910473
57detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.16768140
58sperm motility (GO:0030317)3.15233574
59positive regulation of gamma-delta T cell activation (GO:0046645)3.12417890
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.11422444
61regulation of inclusion body assembly (GO:0090083)3.11096531
62replication fork processing (GO:0031297)3.10828619
63regulation of cilium movement (GO:0003352)3.10319242
64nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.09115787
65protein K6-linked ubiquitination (GO:0085020)3.06910736
66regulation of pigment cell differentiation (GO:0050932)3.05227726
67limb bud formation (GO:0060174)3.05159963
68dorsal/ventral axis specification (GO:0009950)3.03584126
69establishment of protein localization to endoplasmic reticulum (GO:0072599)3.02119238
70regulation of timing of cell differentiation (GO:0048505)3.01313516
71protein K11-linked deubiquitination (GO:0035871)2.99484513
72respiratory chain complex IV assembly (GO:0008535)2.99217674
73cerebral cortex radially oriented cell migration (GO:0021799)2.98356092
74protein localization to endoplasmic reticulum (GO:0070972)2.97224817
75neuron fate determination (GO:0048664)2.94788037
76intraciliary transport (GO:0042073)2.94770853
77centriole replication (GO:0007099)2.94310913
78lymphoid progenitor cell differentiation (GO:0002320)2.94119515
79axonemal dynein complex assembly (GO:0070286)2.93411213
80cellular protein complex disassembly (GO:0043624)2.91004432
81ribosomal small subunit assembly (GO:0000028)2.87332168
82indolalkylamine metabolic process (GO:0006586)2.86976617
83motile cilium assembly (GO:0044458)2.85021479
84N-terminal protein amino acid acetylation (GO:0006474)2.84660181
85double-strand break repair via homologous recombination (GO:0000724)2.82523550
86regulation of metalloenzyme activity (GO:0048552)2.82046102
87sister chromatid cohesion (GO:0007062)2.81811104
88ganglioside metabolic process (GO:0001573)2.81757529
89negative regulation of systemic arterial blood pressure (GO:0003085)2.81189639
90recombinational repair (GO:0000725)2.80869390
91photoreceptor cell maintenance (GO:0045494)2.80195481
92regulation of neuron projection regeneration (GO:0070570)2.80166625
93regulation of axon regeneration (GO:0048679)2.80166625
94cilium morphogenesis (GO:0060271)2.78952727
95protein complex biogenesis (GO:0070271)2.77683200
96hepatocyte differentiation (GO:0070365)2.75818352
97photoreceptor cell development (GO:0042461)2.74203795
98nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.71152310
99N-terminal protein amino acid modification (GO:0031365)2.70338488
100inositol phosphate dephosphorylation (GO:0046855)2.70311489
101phosphorylated carbohydrate dephosphorylation (GO:0046838)2.70311489
102gene silencing by RNA (GO:0031047)2.69162316
103RNA destabilization (GO:0050779)2.69083124
104fucose catabolic process (GO:0019317)2.68831395
105L-fucose metabolic process (GO:0042354)2.68831395
106L-fucose catabolic process (GO:0042355)2.68831395
107sperm capacitation (GO:0048240)2.68259662
108positive regulation of protein autophosphorylation (GO:0031954)2.67769127
109keratinocyte development (GO:0003334)2.67490175
110facial nerve structural organization (GO:0021612)2.67385506
111regulation of meiosis I (GO:0060631)2.67293908
112regulation of development, heterochronic (GO:0040034)2.67078007
113positive regulation of oligodendrocyte differentiation (GO:0048714)2.67047410
114response to pheromone (GO:0019236)2.67032196
115translational elongation (GO:0006414)2.66871401
116interkinetic nuclear migration (GO:0022027)2.66771843
117mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65575022
118mitochondrial respiratory chain complex I assembly (GO:0032981)2.65575022
119NADH dehydrogenase complex assembly (GO:0010257)2.65575022
120mitotic sister chromatid cohesion (GO:0007064)2.63190397
121mitochondrial respiratory chain complex assembly (GO:0033108)2.62833827
122cilium organization (GO:0044782)2.62717803
123glandular epithelial cell differentiation (GO:0002067)2.62320156
124epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.62224895
125protein complex disassembly (GO:0043241)2.61071424
126protein localization to cilium (GO:0061512)2.60845464
127deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.60233581
128indole-containing compound catabolic process (GO:0042436)2.60143422
129indolalkylamine catabolic process (GO:0046218)2.60143422
130tryptophan catabolic process (GO:0006569)2.60143422
131cilium assembly (GO:0042384)2.58890449
132prostate gland growth (GO:0060736)2.57859133
133cytochrome complex assembly (GO:0017004)2.56050854
134epithelial cilium movement (GO:0003351)2.55509025
135eye photoreceptor cell development (GO:0042462)2.55269850
136negative regulation of inclusion body assembly (GO:0090084)2.54084901
137regulation of non-canonical Wnt signaling pathway (GO:2000050)2.53677457
138microtubule anchoring (GO:0034453)2.53231640
139ribosomal large subunit biogenesis (GO:0042273)2.53190419
140kidney morphogenesis (GO:0060993)2.52734463
141regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.52523189
142regulation of mitotic spindle checkpoint (GO:1903504)2.52523189
143negative regulation of transcription regulatory region DNA binding (GO:2000678)2.52447597
144positive regulation of neuroblast proliferation (GO:0002052)2.52257111
145regulation of DNA-dependent DNA replication (GO:0090329)2.51976116
146protein polyglutamylation (GO:0018095)2.51228609
147kynurenine metabolic process (GO:0070189)2.50935516
148DNA ligation (GO:0006266)2.50913412
149positive regulation of meiosis (GO:0045836)2.49984940
150regulation of centriole replication (GO:0046599)2.48987070
151RNA methylation (GO:0001510)2.47845146
152acrosome assembly (GO:0001675)2.47649790
153DNA dealkylation (GO:0035510)2.46268077
154synapsis (GO:0007129)2.46065729
155chromatin remodeling at centromere (GO:0031055)2.45224194
156detection of light stimulus involved in visual perception (GO:0050908)2.45033528
157detection of light stimulus involved in sensory perception (GO:0050962)2.45033528
158DNA methylation involved in gamete generation (GO:0043046)2.44257840
159regulation of nuclear cell cycle DNA replication (GO:0033262)2.43827987
160tryptophan metabolic process (GO:0006568)2.42637850
161piRNA metabolic process (GO:0034587)2.42260740
162reflex (GO:0060004)2.42129078
163lactate metabolic process (GO:0006089)2.41812844
164somite development (GO:0061053)2.41238640
165resolution of meiotic recombination intermediates (GO:0000712)2.40607366
166axoneme assembly (GO:0035082)2.40303997
167regulation of hexokinase activity (GO:1903299)2.40093978
168regulation of glucokinase activity (GO:0033131)2.40093978
169positive regulation of meiotic cell cycle (GO:0051446)2.38802332
170cornea development in camera-type eye (GO:0061303)2.36691324
171regulation of hippo signaling (GO:0035330)2.36021479
172regulation of telomere maintenance (GO:0032204)2.35629339
173regulation of collateral sprouting (GO:0048670)2.29617513
174establishment of protein localization to Golgi (GO:0072600)2.28443843
175histone exchange (GO:0043486)2.26840411
176somatic hypermutation of immunoglobulin genes (GO:0016446)2.26516073
177somatic diversification of immune receptors via somatic mutation (GO:0002566)2.26516073
178regulation of mesoderm development (GO:2000380)2.25228514
179protein neddylation (GO:0045116)2.25147409
180regulation of neurotransmitter uptake (GO:0051580)2.25093668
181attachment of spindle microtubules to kinetochore (GO:0008608)2.23346005
182CENP-A containing nucleosome assembly (GO:0034080)2.22761254
183microtubule organizing center organization (GO:0031023)2.22441312
184serotonin metabolic process (GO:0042428)2.22311507

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human6.86915369
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.38315167
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.16359104
4FLI1_27457419_Chip-Seq_LIVER_Mouse3.00840539
5PCGF2_27294783_Chip-Seq_ESCs_Mouse2.85252476
6NOTCH1_21737748_ChIP-Seq_TLL_Human2.70458974
7IRF1_19129219_ChIP-ChIP_H3396_Human2.61560418
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.60059484
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54597569
10EZH2_22144423_ChIP-Seq_EOC_Human2.45898195
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43806817
12VDR_22108803_ChIP-Seq_LS180_Human2.43767835
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42728662
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.35480361
15* NFE2_27457419_Chip-Seq_LIVER_Mouse2.33537428
16* SUZ12_27294783_Chip-Seq_NPCs_Mouse2.19752761
17SCL_19346495_ChIP-Seq_HPC-7_Human2.17242077
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.16585104
19IGF1R_20145208_ChIP-Seq_DFB_Human2.12087564
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07958101
21GBX2_23144817_ChIP-Seq_PC3_Human1.99170735
22* EZH2_27294783_Chip-Seq_NPCs_Mouse1.97304381
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.96652061
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96606699
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.96428214
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94497328
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.92538092
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.89475642
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.87725740
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.81185059
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.80780969
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.76789076
33* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.75621509
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.75031006
35* P53_22387025_ChIP-Seq_ESCs_Mouse1.74820383
36* ER_23166858_ChIP-Seq_MCF-7_Human1.73612257
37* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.72549221
38* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.69665324
39SMAD4_21799915_ChIP-Seq_A2780_Human1.69099367
40* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.68431380
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68293052
42* NANOG_18555785_Chip-Seq_ESCs_Mouse1.67517170
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.65108075
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64751567
45* STAT3_18555785_Chip-Seq_ESCs_Mouse1.62378054
46* NMYC_18555785_Chip-Seq_ESCs_Mouse1.59700621
47* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59506961
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57352977
49* E2F1_18555785_Chip-Seq_ESCs_Mouse1.56050274
50* CMYC_18555785_Chip-Seq_ESCs_Mouse1.54788243
51* P300_18555785_Chip-Seq_ESCs_Mouse1.54607520
52* OCT4_18555785_Chip-Seq_ESCs_Mouse1.53090021
53CBP_20019798_ChIP-Seq_JUKART_Human1.49075047
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49075047
55* BCAT_22108803_ChIP-Seq_LS180_Human1.49028825
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.47852403
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47804442
58* ZFX_18555785_Chip-Seq_ESCs_Mouse1.47296146
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45717206
60* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.44626231
61* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.43605530
62* AR_25329375_ChIP-Seq_VCAP_Human1.42300457
63TAL1_26923725_Chip-Seq_HPCs_Mouse1.42137147
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41679579
65* EWS_26573619_Chip-Seq_HEK293_Human1.39700748
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39307452
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38039907
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38023313
69* KLF4_18555785_Chip-Seq_ESCs_Mouse1.37581508
70* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37213999
71FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35693143
72* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35494128
73* CTCF_18555785_Chip-Seq_ESCs_Mouse1.34283569
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34059281
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34059281
76TCF4_22108803_ChIP-Seq_LS180_Human1.33754802
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32748420
78E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32581916
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.31855903
80LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31068566
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29846301
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29499899
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28317009
84* SOX2_18555785_Chip-Seq_ESCs_Mouse1.27804585
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27634483
86* PU1_27457419_Chip-Seq_LIVER_Mouse1.26864669
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26194764
88* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.25333116
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24482202
90PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21554654
91* CRX_20693478_ChIP-Seq_RETINA_Mouse1.21415208
92RUNX2_22187159_ChIP-Seq_PCA_Human1.21256928
93RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.20747847
94CBX2_27304074_Chip-Seq_ESCs_Mouse1.20603942
95* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20458656
96* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19754683
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18918515
98STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.18879430
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17564746
100E2F4_17652178_ChIP-ChIP_JURKAT_Human1.15385287
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14378226
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13339406
103CDX2_20551321_ChIP-Seq_CACO-2_Human1.13175815
104* SOX2_19829295_ChIP-Seq_ESCs_Human1.12954613
105* NANOG_19829295_ChIP-Seq_ESCs_Human1.12954613
106* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.12693058
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11782029
108FLI1_21867929_ChIP-Seq_TH2_Mouse1.11700407
109PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11195695
110FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.11087284
111RNF2_27304074_Chip-Seq_NSC_Mouse1.10804346
112MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10202046
113TP53_22573176_ChIP-Seq_HFKS_Human1.09893991
114* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09550662
115TAF15_26573619_Chip-Seq_HEK293_Human1.09308667
116HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09121635
117TP53_16413492_ChIP-PET_HCT116_Human1.08593367
118PRDM14_20953172_ChIP-Seq_ESCs_Human1.08316831
119POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06717797
120ELK1_19687146_ChIP-ChIP_HELA_Human1.05496586
121CDX2_22108803_ChIP-Seq_LS180_Human1.05435362
122RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04891600
123SMAD_19615063_ChIP-ChIP_OVARY_Human1.04689368
124SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04197116
125SALL1_21062744_ChIP-ChIP_HESCs_Human1.03894612
126SMAD4_21741376_ChIP-Seq_EPCs_Human1.03749170
127* STAT3_23295773_ChIP-Seq_U87_Human1.03383854
128PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03136766
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02481962
130P300_19829295_ChIP-Seq_ESCs_Human1.01270108
131STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00943933
132MYC_18940864_ChIP-ChIP_HL60_Human1.00739208
133TP63_19390658_ChIP-ChIP_HaCaT_Human1.00367859
134FUS_26573619_Chip-Seq_HEK293_Human1.00344245
135* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99126437
136* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98766552
137JUN_21703547_ChIP-Seq_K562_Human0.98115983
138* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97633354
139CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97109712
140TP53_18474530_ChIP-ChIP_U2OS_Human0.97081198
141AR_21572438_ChIP-Seq_LNCaP_Human0.93068312
142EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92799731
143CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92428566
144SMAD3_21741376_ChIP-Seq_EPCs_Human0.91556859
145ZNF274_21170338_ChIP-Seq_K562_Hela0.91252906
146* TCF4_23295773_ChIP-Seq_U87_Human0.90031934
147* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89692459

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode6.25281579
2MP0003136_yellow_coat_color4.25389459
3MP0000566_synostosis3.84488920
4MP0009379_abnormal_foot_pigmentation3.68184353
5MP0001188_hyperpigmentation3.28966832
6MP0003183_abnormal_peptide_metabolism2.85830563
7MP0005409_darkened_coat_color2.85270567
8MP0004381_abnormal_hair_follicle2.82344429
9MP0002938_white_spotting2.67281299
10MP0000516_abnormal_urinary_system2.53546451
11MP0005367_renal/urinary_system_phenotyp2.53546451
12MP0008877_abnormal_DNA_methylation2.49365645
13MP0003868_abnormal_feces_composition2.42459757
14MP0008260_abnormal_autophagy2.42446315
15MP0005410_abnormal_fertilization2.36839897
16MP0003806_abnormal_nucleotide_metabolis2.25346356
17MP0005174_abnormal_tail_pigmentation2.24713386
18MP0000569_abnormal_digit_pigmentation2.19278957
19MP0005084_abnormal_gallbladder_morpholo2.10794374
20MP0005075_abnormal_melanosome_morpholog2.03752545
21MP0002234_abnormal_pharynx_morphology2.01397596
22MP0003195_calcinosis1.94981085
23MP0000427_abnormal_hair_cycle1.90504674
24MP0001485_abnormal_pinna_reflex1.90474502
25MP0002638_abnormal_pupillary_reflex1.86003284
26MP0000678_abnormal_parathyroid_gland1.84251070
27MP0005646_abnormal_pituitary_gland1.79440748
28MP0004134_abnormal_chest_morphology1.78359046
29MP0003763_abnormal_thymus_physiology1.76514419
30MP0008007_abnormal_cellular_replicative1.71019046
31MP0003011_delayed_dark_adaptation1.67026119
32MP0002736_abnormal_nociception_after1.66924812
33MP0001984_abnormal_olfaction1.63082837
34MP0000015_abnormal_ear_pigmentation1.61695253
35MP0004147_increased_porphyrin_level1.60093625
36MP0009697_abnormal_copulation1.56395884
37MP0002177_abnormal_outer_ear1.54321228
38MP0001968_abnormal_touch/_nociception1.48261611
39MP0009046_muscle_twitch1.47143793
40MP0003646_muscle_fatigue1.47094507
41MP0005645_abnormal_hypothalamus_physiol1.46918052
42MP0003718_maternal_effect1.43091487
43MP0009250_abnormal_appendicular_skeleto1.40329895
44MP0000681_abnormal_thyroid_gland1.37998492
45MP0003938_abnormal_ear_development1.37812456
46MP0002837_dystrophic_cardiac_calcinosis1.36612397
47MP0003787_abnormal_imprinting1.35341059
48MP0000490_abnormal_crypts_of1.34391641
49MP0004133_heterotaxia1.34020663
50MP0001929_abnormal_gametogenesis1.34002826
51MP0000631_abnormal_neuroendocrine_gland1.33421189
52MP0008058_abnormal_DNA_repair1.30529110
53MP0002751_abnormal_autonomic_nervous1.30116502
54MP0003121_genomic_imprinting1.29169545
55MP0002876_abnormal_thyroid_physiology1.28618271
56MP0000647_abnormal_sebaceous_gland1.25814759
57MP0002095_abnormal_skin_pigmentation1.25748800
58MP0002210_abnormal_sex_determination1.25619687
59MP0003755_abnormal_palate_morphology1.25092926
60MP0003880_abnormal_central_pattern1.24894184
61MP0002928_abnormal_bile_duct1.23253348
62MP0002282_abnormal_trachea_morphology1.23220076
63MP0002272_abnormal_nervous_system1.22368996
64MP0003698_abnormal_male_reproductive1.21517043
65MP0005187_abnormal_penis_morphology1.20839005
66MP0000372_irregular_coat_pigmentation1.20666335
67MP0002277_abnormal_respiratory_mucosa1.19698249
68MP0006072_abnormal_retinal_apoptosis1.17224356
69MP0001145_abnormal_male_reproductive1.12614380
70MP0000778_abnormal_nervous_system1.12484421
71MP0008872_abnormal_physiological_respon1.12354884
72MP0004142_abnormal_muscle_tone1.11967747
73MP0006276_abnormal_autonomic_nervous1.11742171
74MP0000465_gastrointestinal_hemorrhage1.10212898
75MP0003283_abnormal_digestive_organ1.09692547
76MP0002233_abnormal_nose_morphology1.09116085
77MP0001486_abnormal_startle_reflex1.08929056
78MP0003943_abnormal_hepatobiliary_system1.08391570
79MP0009745_abnormal_behavioral_response1.07581518
80MP0010386_abnormal_urinary_bladder1.07176897
81MP0003941_abnormal_skin_development1.06707467
82MP0008789_abnormal_olfactory_epithelium1.06296081
83MP0002009_preneoplasia1.05673441
84MP0010094_abnormal_chromosome_stability1.03460941
85MP0000858_altered_metastatic_potential1.02991010
86MP0001324_abnormal_eye_pigmentation1.02926097
87MP0010678_abnormal_skin_adnexa1.00269874
88MP0003866_abnormal_defecation0.99948243
89MP0010307_abnormal_tumor_latency0.98501272
90MP0000049_abnormal_middle_ear0.98034628
91MP0000538_abnormal_urinary_bladder0.97921082
92MP0003786_premature_aging0.97183816
93MP0002557_abnormal_social/conspecific_i0.97133802
94MP0002163_abnormal_gland_morphology0.96907512
95MP0002752_abnormal_somatic_nervous0.96792229
96MP0000653_abnormal_sex_gland0.96213042
97MP0002184_abnormal_innervation0.95346979
98MP0003567_abnormal_fetal_cardiomyocyte0.95268776
99MP0002075_abnormal_coat/hair_pigmentati0.94530487
100MP0001293_anophthalmia0.93962345
101MP0001186_pigmentation_phenotype0.92902709
102MP0001873_stomach_inflammation0.92720695
103MP0004145_abnormal_muscle_electrophysio0.92634598
104MP0003950_abnormal_plasma_membrane0.91452664
105MP0001944_abnormal_pancreas_morphology0.91419278
106MP0003111_abnormal_nucleus_morphology0.91153389
107MP0005551_abnormal_eye_electrophysiolog0.90879342
108MP0003119_abnormal_digestive_system0.90800906
109MP0001529_abnormal_vocalization0.90073352
110MP0004043_abnormal_pH_regulation0.89274218
111MP0002160_abnormal_reproductive_system0.88770756
112MP0000703_abnormal_thymus_morphology0.88689726
113MP0005253_abnormal_eye_physiology0.88491777
114MP0001986_abnormal_taste_sensitivity0.86384342
115MP0001800_abnormal_humoral_immune0.84887325
116MP0001286_abnormal_eye_development0.84472927
117MP0001501_abnormal_sleep_pattern0.84066354
118MP0008995_early_reproductive_senescence0.82452075
119MP0005391_vision/eye_phenotype0.81802878
120MP0002254_reproductive_system_inflammat0.80649791
121MP0005379_endocrine/exocrine_gland_phen0.80001106
122MP0000613_abnormal_salivary_gland0.79975959
123MP0003936_abnormal_reproductive_system0.79935279
124MP0005671_abnormal_response_to0.79367375
125MP0004215_abnormal_myocardial_fiber0.79218887
126MP0009780_abnormal_chondrocyte_physiolo0.78034487
127MP0005389_reproductive_system_phenotype0.77735936
128MP0005670_abnormal_white_adipose0.77649653
129MP0004885_abnormal_endolymph0.75632559
130MP0003890_abnormal_embryonic-extraembry0.74836160
131MP0002420_abnormal_adaptive_immunity0.74422915
132MP0001919_abnormal_reproductive_system0.74234823
133MP0002398_abnormal_bone_marrow0.74146402
134MP0005195_abnormal_posterior_eye0.73836144
135MP0005257_abnormal_intraocular_pressure0.72822451
136MP0001819_abnormal_immune_cell0.72309264
137MP0005171_absent_coat_pigmentation0.70837347
138MP0002693_abnormal_pancreas_physiology0.69771675
139MP0005408_hypopigmentation0.69399749
140MP0002723_abnormal_immune_serum0.67887636
141MP0002102_abnormal_ear_morphology0.66506063
142MP0000383_abnormal_hair_follicle0.66499557
143MP0003937_abnormal_limbs/digits/tail_de0.66160573
144MP0001346_abnormal_lacrimal_gland0.66028102
145MP0000371_diluted_coat_color0.65952963
146MP0005248_abnormal_Harderian_gland0.65305718
147MP0005394_taste/olfaction_phenotype0.64563931
148MP0005499_abnormal_olfactory_system0.64563931
149MP0000026_abnormal_inner_ear0.64372299
150MP0008057_abnormal_DNA_replication0.64285390
151MP0002933_joint_inflammation0.63630876
152MP0009333_abnormal_splenocyte_physiolog0.63471796
153MP0002452_abnormal_antigen_presenting0.62853738
154MP0002161_abnormal_fertility/fecundity0.60759473
155MP0002138_abnormal_hepatobiliary_system0.60505027

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the axillary hair (HP:0100134)4.94031736
2Abnormality of secondary sexual hair (HP:0009888)4.94031736
3Abnormal biliary tract physiology (HP:0012439)4.20246747
4Bile duct proliferation (HP:0001408)4.20246747
5Long nose (HP:0003189)4.11047065
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.53117409
7Decreased circulating renin level (HP:0003351)3.44743843
8Medial flaring of the eyebrow (HP:0010747)3.26694834
9Thyroid-stimulating hormone excess (HP:0002925)3.24905794
10Reduced antithrombin III activity (HP:0001976)3.17438114
11Pendular nystagmus (HP:0012043)3.09955740
12Dynein arm defect of respiratory motile cilia (HP:0012255)2.92493049
13Absent/shortened dynein arms (HP:0200106)2.92493049
14Type I transferrin isoform profile (HP:0003642)2.90458730
15Abnormality of the phalanges of the hallux (HP:0010057)2.84141895
16Aplasia/hypoplasia of the uterus (HP:0008684)2.82490657
17Abnormality of the renal cortex (HP:0011035)2.75834502
18Reticulocytopenia (HP:0001896)2.75590007
19Hypoplasia of the uterus (HP:0000013)2.73645365
20Renal cortical cysts (HP:0000803)2.73250197
21Nonprogressive disorder (HP:0003680)2.72227145
22Congenital primary aphakia (HP:0007707)2.67852054
23Gait imbalance (HP:0002141)2.64816726
24Optic nerve coloboma (HP:0000588)2.64499148
25Dry hair (HP:0011359)2.63952111
26Abolished electroretinogram (ERG) (HP:0000550)2.61588515
27Absent rod-and cone-mediated responses on ERG (HP:0007688)2.61270982
28Genital tract atresia (HP:0001827)2.60734687
29Colon cancer (HP:0003003)2.58788838
30Nephronophthisis (HP:0000090)2.57385493
31Pancreatic fibrosis (HP:0100732)2.56862170
32Abnormality of midbrain morphology (HP:0002418)2.55987238
33Molar tooth sign on MRI (HP:0002419)2.55987238
34Vaginal atresia (HP:0000148)2.54937124
35Fair hair (HP:0002286)2.54934228
36Pseudobulbar signs (HP:0002200)2.51875045
37Attenuation of retinal blood vessels (HP:0007843)2.51687798
38Supernumerary spleens (HP:0009799)2.49797316
39Muscle fiber atrophy (HP:0100295)2.48907801
40Keratoconus (HP:0000563)2.47980052
41Increased corneal curvature (HP:0100692)2.47980052
42True hermaphroditism (HP:0010459)2.46980045
43Methylmalonic acidemia (HP:0002912)2.46533459
44Type 2 muscle fiber atrophy (HP:0003554)2.46112944
45Abnormality of chromosome stability (HP:0003220)2.43136250
46Neoplasm of the adrenal cortex (HP:0100641)2.41507450
47Nephrogenic diabetes insipidus (HP:0009806)2.40745599
483-Methylglutaconic aciduria (HP:0003535)2.40551608
49Prominent supraorbital ridges (HP:0000336)2.38652451
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.36683730
51Volvulus (HP:0002580)2.35653782
52Abnormal rod and cone electroretinograms (HP:0008323)2.33330429
53Anhidrosis (HP:0000970)2.32072371
54Abnormality of renin-angiotensin system (HP:0000847)2.31384237
55Macrocytic anemia (HP:0001972)2.29838018
56Abnormal protein glycosylation (HP:0012346)2.29263413
57Abnormal glycosylation (HP:0012345)2.29263413
58Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29263413
59Abnormal protein N-linked glycosylation (HP:0012347)2.29263413
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.28369617
61Septo-optic dysplasia (HP:0100842)2.28077713
62Abnormal hemoglobin (HP:0011902)2.27757509
63Absent hair (HP:0002298)2.27687264
64Cone-rod dystrophy (HP:0000548)2.26173338
65Poor coordination (HP:0002370)2.22706533
66Chronic mucocutaneous candidiasis (HP:0002728)2.22106624
67Recurrent cutaneous fungal infections (HP:0011370)2.22106624
68Irregular vertebral endplates (HP:0003301)2.20547219
69Hyperactive renin-angiotensin system (HP:0000841)2.19895062
70Furrowed tongue (HP:0000221)2.19180948
71Sclerocornea (HP:0000647)2.18902750
72Chorioretinal atrophy (HP:0000533)2.18643189
73Gaze-evoked nystagmus (HP:0000640)2.17364361
74Decreased central vision (HP:0007663)2.17299582
75Scrotal hypoplasia (HP:0000046)2.15201122
76Hyperventilation (HP:0002883)2.15133783
77Flat capital femoral epiphysis (HP:0003370)2.13814650
78Amelogenesis imperfecta (HP:0000705)2.13135127
79Congenital stationary night blindness (HP:0007642)2.11961493
80Concave nail (HP:0001598)2.11737328
81Abnormality of the renal medulla (HP:0100957)2.10692251
82Pancreatic cysts (HP:0001737)2.09122470
83Chromsome breakage (HP:0040012)2.06969453
84Intestinal atresia (HP:0011100)2.06880338
85Hypotelorism (HP:0000601)2.06804816
86Polar cataract (HP:0010696)2.06248453
87Abnormality of the phalanges of the 2nd finger (HP:0009541)2.04965879
88Postaxial hand polydactyly (HP:0001162)2.04269149
89Small hand (HP:0200055)2.03864694
90Parakeratosis (HP:0001036)2.03695222
91Short tibia (HP:0005736)2.02793380
92Abnormal respiratory motile cilium physiology (HP:0012261)2.01944869
93Abnormality of the ileum (HP:0001549)2.01216898
94Glioma (HP:0009733)2.00956274
95Hypoplasia of the fovea (HP:0007750)2.00833942
96Aplasia/Hypoplasia of the fovea (HP:0008060)2.00833942
97Acute necrotizing encephalopathy (HP:0006965)1.99242726
98Abnormality of cells of the erythroid lineage (HP:0012130)1.98114183
99Congenital hepatic fibrosis (HP:0002612)1.97677146
100Tented upper lip vermilion (HP:0010804)1.96825317
101Chronic bronchitis (HP:0004469)1.96762966
102Preaxial hand polydactyly (HP:0001177)1.96388624
103Median cleft lip (HP:0000161)1.95674489
104Tubular atrophy (HP:0000092)1.93512992
105Sloping forehead (HP:0000340)1.93148641
106Type II lissencephaly (HP:0007260)1.93004697
107Progressive macrocephaly (HP:0004481)1.92479657
108Triphalangeal thumb (HP:0001199)1.92014831
109Abnormal number of erythroid precursors (HP:0012131)1.91672239
110Hyponatremia (HP:0002902)1.91100438
111Chronic hepatic failure (HP:0100626)1.90520878
112Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90186487
113Generalized hypopigmentation of hair (HP:0011358)1.89837651
114Hyperglycinemia (HP:0002154)1.88916446
115Astigmatism (HP:0000483)1.87725701
116Abnormal delayed hypersensitivity skin test (HP:0002963)1.86110388
117Hyperinsulinemic hypoglycemia (HP:0000825)1.85726595
118Chromosomal breakage induced by crosslinking agents (HP:0003221)1.84259677
119Methylmalonic aciduria (HP:0012120)1.83728276
120Abnormality of chloride homeostasis (HP:0011422)1.83188117
121Male pseudohermaphroditism (HP:0000037)1.82822610
122Increased CSF lactate (HP:0002490)1.82752715
123Azoospermia (HP:0000027)1.82701619
124Drooling (HP:0002307)1.82411073
125Excessive salivation (HP:0003781)1.82411073
126Abnormality of the labia minora (HP:0012880)1.82139720
127Abnormality of DNA repair (HP:0003254)1.81832699
128Sensory axonal neuropathy (HP:0003390)1.80077663
129Hamartoma of the eye (HP:0010568)1.79818927
130Fibular hypoplasia (HP:0003038)1.79724882
131Gonadotropin excess (HP:0000837)1.79477661
132Ectopic kidney (HP:0000086)1.79006298
133Abnormal spermatogenesis (HP:0008669)1.78486199
134Abnormality of the proximal phalanges of the hand (HP:0009834)1.78124798
135Aplasia/Hypoplasia of the fibula (HP:0006492)1.77781077
136Aplasia/Hypoplasia of the tongue (HP:0010295)1.77281284
137Hypothermia (HP:0002045)1.77185078
138Acute encephalopathy (HP:0006846)1.77089479
139Anencephaly (HP:0002323)1.77006753
140Hypoplastic pelvis (HP:0008839)1.75886637
141Astrocytoma (HP:0009592)1.74920111
142Abnormality of the astrocytes (HP:0100707)1.74920111
143Cystic liver disease (HP:0006706)1.74827801
144Postaxial foot polydactyly (HP:0001830)1.74564554
145Abnormal pupillary function (HP:0007686)1.74250179
146Metabolic alkalosis (HP:0200114)1.74190780
147Prominent metopic ridge (HP:0005487)1.73635029
148Conjugated hyperbilirubinemia (HP:0002908)1.72719822
149Pallor (HP:0000980)1.71961909
150Hypoplasia of the radius (HP:0002984)1.71519380
151Congenital, generalized hypertrichosis (HP:0004540)1.71380486
152Abnormality of dental color (HP:0011073)1.70379736
153Mitochondrial inheritance (HP:0001427)1.69701574
154Stenosis of the external auditory canal (HP:0000402)1.69184900
155Tubulointerstitial nephritis (HP:0001970)1.68058095
156Absent thumb (HP:0009777)1.67986028
157Bifid tongue (HP:0010297)1.67640619
158Specific learning disability (HP:0001328)1.67611334
159Stomach cancer (HP:0012126)1.67190375
160Dandy-Walker malformation (HP:0001305)1.67150697
161Meningitis (HP:0001287)1.67137892
162Broad-based gait (HP:0002136)1.66992688
163Meckel diverticulum (HP:0002245)1.66956198
164Absent septum pellucidum (HP:0001331)1.66072603
165Abnormality of the metopic suture (HP:0005556)1.65966364
166Optic nerve hypoplasia (HP:0000609)1.65582183
167Gastrointestinal atresia (HP:0002589)1.65444114
168Homocystinuria (HP:0002156)1.65415621
169Abnormality of homocysteine metabolism (HP:0010919)1.65415621
170Abnormality of the wing of the ilium (HP:0011867)1.65267637
171Meningioma (HP:0002858)1.64789226
172Short foot (HP:0001773)1.64688281
173Short hallux (HP:0010109)1.63382711
174Oligohydramnios (HP:0001562)1.62566548
175Oligodactyly (hands) (HP:0001180)1.60031750

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD23.73026088
2CASK3.66436534
3INSRR3.58382260
4IRAK33.11593393
5MUSK3.01889376
6TLK12.95969032
7WNK32.78583559
8CDK32.67948970
9SRPK12.64557237
10TNIK2.61985390
11STK382.59963346
12CLK12.55699936
13IRAK42.35138256
14NEK12.34005363
15TRIM282.24840913
16IRAK12.21917714
17BRD42.13809906
18TXK2.13646619
19NLK2.12608045
20GRK12.08421164
21MAPK152.08178872
22IRAK21.98328669
23TAOK31.96434048
24BRSK21.93746596
25ACVR1B1.83284557
26YES11.74420953
27HIPK21.67428137
28MAPKAPK51.64902079
29MAP4K21.62654788
30MKNK21.62620258
31MAP3K41.60755162
32TAF11.58784552
33BMPR1B1.58292862
34PLK21.55286451
35MAPK131.49679323
36DYRK31.49285781
37LATS11.44028597
38PLK31.39715238
39VRK11.37082959
40PNCK1.35427492
41FGFR21.34853513
42TGFBR21.34590859
43PINK11.31610582
44PAK31.31587217
45MAP3K101.30010447
46STK31.25719266
47ERBB31.25303385
48CSNK1G31.23372289
49CSNK1G21.21955329
50BUB11.20542180
51NUAK11.17792962
52MST41.14278945
53TSSK61.13267194
54WEE11.12707759
55OXSR11.11289188
56CDC71.09975602
57STK241.07423219
58MAP3K121.04383713
59PRKCE0.98844208
60DYRK1B0.95875995
61NME20.94915873
62MAP4K10.93999586
63AKT30.92336284
64CDK80.91107924
65ADRBK20.89037794
66STK110.88094897
67TEC0.88018158
68BCR0.87486376
69PIK3CG0.87150063
70EPHA40.86943992
71BTK0.86289033
72STK390.83450808
73PLK10.83203989
74PRKCG0.80893299
75PASK0.80173106
76UHMK10.78071503
77VRK20.77226400
78CDK90.75443143
79PDK20.75407742
80NTRK30.75094876
81TAOK20.74609221
82PLK40.72815977
83MKNK10.71835258
84WNK10.69688176
85FER0.68463441
86EIF2AK20.67910467
87KIT0.67640191
88MAPK110.67057322
89PIM10.65398209
90BLK0.64789840
91CSNK1G10.64723386
92ADRBK10.63430289
93PIK3CA0.62536844
94STK100.60107834
95CDK70.59081948
96EIF2AK30.58369363
97FGFR10.57613290
98IKBKE0.54901747
99FLT30.54841098
100ZAK0.54511370
101LYN0.54422395
102PRKCI0.53747862
103DYRK1A0.52674432
104PKN10.51560688
105NEK20.51307380
106EPHB10.50740076
107MAP3K30.50401400
108STK160.50142678
109TTK0.49824591
110GRK60.47798532
111CSNK1A10.47162665
112SGK20.46369130
113BMPR20.46348965
114BCKDK0.45549383
115PBK0.45459637
116CSNK1D0.45080575
117CSNK1E0.44764348
118EIF2AK10.43243802
119TGFBR10.43225003
120WNK40.42870186
121MAP3K140.42858462
122CDK60.42398426
123RPS6KA50.42369547
124CSNK1A1L0.42186234
125FRK0.41314492
126BRSK10.40719647
127GRK70.38445635
128CDK40.37569871
129CAMK2A0.37532729
130PTK2B0.36234884
131DYRK20.35300311
132CHEK20.34744376
133PRKG10.34492833
134RPS6KB20.34141905
135CAMK1G0.33690008
136MARK20.32685409
137LCK0.32652942
138IKBKB0.32416799
139IGF1R0.32287474
140AURKB0.32144534
141RPS6KA40.31978625
142PRKACA0.31964209
143SGK2230.31633278
144SGK4940.31633278
145NEK60.31428541
146ATR0.30947287
147MELK0.30630784
148PRKD10.28375093
149ABL10.28012505
150MAP2K70.26882590
151CAMK2B0.26098307
152FGR0.26051032
153CSK0.25692938
154CSF1R0.25593420
155ATM0.24926742
156STK38L0.24787508
157EPHA30.24173406

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.07188462
2Ribosome_Homo sapiens_hsa030103.66160437
3Protein export_Homo sapiens_hsa030602.77165540
4Basal transcription factors_Homo sapiens_hsa030222.69051027
5Fanconi anemia pathway_Homo sapiens_hsa034602.53065566
6Homologous recombination_Homo sapiens_hsa034402.42756964
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.32884384
8Ether lipid metabolism_Homo sapiens_hsa005652.21298075
9RNA degradation_Homo sapiens_hsa030182.06839598
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.93786601
11Oxidative phosphorylation_Homo sapiens_hsa001901.92956112
12Proteasome_Homo sapiens_hsa030501.89364096
13Propanoate metabolism_Homo sapiens_hsa006401.88222641
14Nitrogen metabolism_Homo sapiens_hsa009101.87687118
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.78826249
16Other glycan degradation_Homo sapiens_hsa005111.77639236
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74294375
18Phototransduction_Homo sapiens_hsa047441.73259992
19RNA polymerase_Homo sapiens_hsa030201.69759408
20Spliceosome_Homo sapiens_hsa030401.68539178
21Sphingolipid metabolism_Homo sapiens_hsa006001.65849966
22Nicotine addiction_Homo sapiens_hsa050331.64432823
23DNA replication_Homo sapiens_hsa030301.63030479
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59673236
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.57409316
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55480301
27Butanoate metabolism_Homo sapiens_hsa006501.52136272
28Inositol phosphate metabolism_Homo sapiens_hsa005621.51222795
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.49598153
30Primary immunodeficiency_Homo sapiens_hsa053401.49514214
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47224089
32Pyrimidine metabolism_Homo sapiens_hsa002401.44785633
33Parkinsons disease_Homo sapiens_hsa050121.42623241
34Non-homologous end-joining_Homo sapiens_hsa034501.38234793
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32678199
36Mismatch repair_Homo sapiens_hsa034301.32073446
37Measles_Homo sapiens_hsa051621.28831527
38Linoleic acid metabolism_Homo sapiens_hsa005911.26402770
39One carbon pool by folate_Homo sapiens_hsa006701.25548599
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25454105
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.23181629
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22272398
43Base excision repair_Homo sapiens_hsa034101.21977711
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19937966
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.19862161
46Folate biosynthesis_Homo sapiens_hsa007901.18342523
47Thyroid cancer_Homo sapiens_hsa052161.18059662
48Huntingtons disease_Homo sapiens_hsa050161.18007955
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16509538
50RNA transport_Homo sapiens_hsa030131.13923313
51Caffeine metabolism_Homo sapiens_hsa002321.09971022
52Systemic lupus erythematosus_Homo sapiens_hsa053221.09413619
53Antigen processing and presentation_Homo sapiens_hsa046121.08404822
54Basal cell carcinoma_Homo sapiens_hsa052171.07480600
55Purine metabolism_Homo sapiens_hsa002301.06643579
56TGF-beta signaling pathway_Homo sapiens_hsa043501.05287253
57ABC transporters_Homo sapiens_hsa020101.04537741
58Chemical carcinogenesis_Homo sapiens_hsa052041.03775388
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03733960
60Sulfur relay system_Homo sapiens_hsa041221.02291418
61Steroid biosynthesis_Homo sapiens_hsa001000.97673127
62Sulfur metabolism_Homo sapiens_hsa009200.96342076
63Regulation of autophagy_Homo sapiens_hsa041400.96334847
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96286728
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95920056
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95215667
67Hematopoietic cell lineage_Homo sapiens_hsa046400.94229566
68Alzheimers disease_Homo sapiens_hsa050100.93913904
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.93315834
70Nucleotide excision repair_Homo sapiens_hsa034200.93260050
71Peroxisome_Homo sapiens_hsa041460.93033849
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89088120
73N-Glycan biosynthesis_Homo sapiens_hsa005100.86900117
74Arachidonic acid metabolism_Homo sapiens_hsa005900.86275858
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84955591
76Herpes simplex infection_Homo sapiens_hsa051680.83708309
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.83263231
78p53 signaling pathway_Homo sapiens_hsa041150.78858292
79Retinol metabolism_Homo sapiens_hsa008300.76803878
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75925826
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75751318
82Acute myeloid leukemia_Homo sapiens_hsa052210.74493979
83Hippo signaling pathway_Homo sapiens_hsa043900.73417155
84Tryptophan metabolism_Homo sapiens_hsa003800.72607365
85Dorso-ventral axis formation_Homo sapiens_hsa043200.72405766
86Melanoma_Homo sapiens_hsa052180.72223162
87Wnt signaling pathway_Homo sapiens_hsa043100.72222885
88Olfactory transduction_Homo sapiens_hsa047400.71995838
89Glutamatergic synapse_Homo sapiens_hsa047240.71992543
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71886688
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.70745291
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70452379
93Serotonergic synapse_Homo sapiens_hsa047260.69547811
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68903594
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68064344
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67425427
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66978926
98Vitamin digestion and absorption_Homo sapiens_hsa049770.65840584
99Prostate cancer_Homo sapiens_hsa052150.65540742
100Cardiac muscle contraction_Homo sapiens_hsa042600.64894245
101Morphine addiction_Homo sapiens_hsa050320.62722332
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62706402
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61237657
104Autoimmune thyroid disease_Homo sapiens_hsa053200.59431911
105Dopaminergic synapse_Homo sapiens_hsa047280.58887372
106Circadian entrainment_Homo sapiens_hsa047130.58436472
107Cell cycle_Homo sapiens_hsa041100.58140145
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.57086277
109Oocyte meiosis_Homo sapiens_hsa041140.55962089
110Mineral absorption_Homo sapiens_hsa049780.55789593
111Fatty acid degradation_Homo sapiens_hsa000710.55590176
112T cell receptor signaling pathway_Homo sapiens_hsa046600.55136308
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53597178
114beta-Alanine metabolism_Homo sapiens_hsa004100.53466916
115Hedgehog signaling pathway_Homo sapiens_hsa043400.53013639
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52544569
117Selenocompound metabolism_Homo sapiens_hsa004500.52307282
118Vitamin B6 metabolism_Homo sapiens_hsa007500.51286264
119Collecting duct acid secretion_Homo sapiens_hsa049660.50705817
120TNF signaling pathway_Homo sapiens_hsa046680.50616842
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50487667
122Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49000348
123Taste transduction_Homo sapiens_hsa047420.47706591
124Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47328305
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47112721
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47099345
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46273366
128GABAergic synapse_Homo sapiens_hsa047270.46261670
129Graft-versus-host disease_Homo sapiens_hsa053320.46014738
130Glutathione metabolism_Homo sapiens_hsa004800.45927858
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45774211
132Fatty acid elongation_Homo sapiens_hsa000620.43687772
133Notch signaling pathway_Homo sapiens_hsa043300.42330512
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41295113
135Alcoholism_Homo sapiens_hsa050340.41027316
136Insulin secretion_Homo sapiens_hsa049110.40821264
137Ovarian steroidogenesis_Homo sapiens_hsa049130.40716248
138Colorectal cancer_Homo sapiens_hsa052100.39915051
139Circadian rhythm_Homo sapiens_hsa047100.39415171
140Salivary secretion_Homo sapiens_hsa049700.38713920
141Long-term depression_Homo sapiens_hsa047300.37448592
142Glycerolipid metabolism_Homo sapiens_hsa005610.36966147
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.36385718
144Epstein-Barr virus infection_Homo sapiens_hsa051690.36111227
145B cell receptor signaling pathway_Homo sapiens_hsa046620.36087558
146Viral carcinogenesis_Homo sapiens_hsa052030.32856725
147Leishmaniasis_Homo sapiens_hsa051400.32745075
148Metabolic pathways_Homo sapiens_hsa011000.32451113
149FoxO signaling pathway_Homo sapiens_hsa040680.32296403
150Histidine metabolism_Homo sapiens_hsa003400.31517985
151Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29957949
152Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28601494

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »