GPATCH2L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of developmental pigmentation (GO:0048087)5.12657029
2regulation of pigment cell differentiation (GO:0050932)4.67232793
3histone H3-K4 trimethylation (GO:0080182)4.57245557
4phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.42669579
5establishment of protein localization to Golgi (GO:0072600)4.41675185
6positive regulation of gamma-delta T cell activation (GO:0046645)4.40059254
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.36275614
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.36201270
9negative regulation of cell killing (GO:0031342)4.36201270
10negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.22967884
11negative regulation of translation, ncRNA-mediated (GO:0040033)4.22967884
12regulation of translation, ncRNA-mediated (GO:0045974)4.22967884
13regulation of interferon-beta biosynthetic process (GO:0045357)4.06023196
14interkinetic nuclear migration (GO:0022027)3.93343606
15peptidyl-lysine trimethylation (GO:0018023)3.91626111
16positive regulation of B cell differentiation (GO:0045579)3.82580380
17protein targeting to Golgi (GO:0000042)3.74284609
18neural tube formation (GO:0001841)3.72588650
19response to pheromone (GO:0019236)3.66015768
20cellular response to ethanol (GO:0071361)3.63032045
21protein K11-linked deubiquitination (GO:0035871)3.58038148
22antigen processing and presentation of endogenous antigen (GO:0019883)3.54770352
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.54086037
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.54086037
25regulation of B cell receptor signaling pathway (GO:0050855)3.40523989
26microtubule anchoring (GO:0034453)3.38934769
27regulation of interleukin-12 biosynthetic process (GO:0045075)3.36774964
28histone H3-K9 methylation (GO:0051567)3.34926442
29regulation of ARF protein signal transduction (GO:0032012)3.32496520
30macrophage activation involved in immune response (GO:0002281)3.26484034
31regulation of gamma-delta T cell differentiation (GO:0045586)3.24017036
32regulation of establishment of cell polarity (GO:2000114)3.23703187
33protein K48-linked deubiquitination (GO:0071108)3.21248662
34histone mRNA catabolic process (GO:0071044)3.20300491
35pre-miRNA processing (GO:0031054)3.18917748
36peptidyl-lysine methylation (GO:0018022)3.16086678
37cortical actin cytoskeleton organization (GO:0030866)3.15906495
38negative thymic T cell selection (GO:0045060)3.13454383
39B cell receptor signaling pathway (GO:0050853)3.12174200
40regulation of gamma-delta T cell activation (GO:0046643)3.11573611
41presynaptic membrane assembly (GO:0097105)3.11171205
42regulation of B cell differentiation (GO:0045577)3.06845444
43lipid translocation (GO:0034204)3.04436339
44phospholipid translocation (GO:0045332)3.04436339
45positive regulation of histone deacetylation (GO:0031065)3.02170867
46negative T cell selection (GO:0043383)3.00090828
47pericardium development (GO:0060039)2.99583009
48protein prenylation (GO:0018342)2.95905442
49prenylation (GO:0097354)2.95905442
50histone H3-K9 modification (GO:0061647)2.95375653
51locomotory exploration behavior (GO:0035641)2.93751026
52modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.92856403
53positive regulation by organism of defense response of other organism involved in symbiotic interact2.92856403
54modulation by symbiont of host immune response (GO:0052553)2.92856403
55positive regulation by symbiont of host defense response (GO:0052509)2.92856403
56modulation by symbiont of host defense response (GO:0052031)2.92856403
57modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.92856403
58NLS-bearing protein import into nucleus (GO:0006607)2.92130051
59synaptic vesicle maturation (GO:0016188)2.92103560
60clathrin coat assembly (GO:0048268)2.89675796
61regulation of ARF GTPase activity (GO:0032312)2.88884094
62histone lysine methylation (GO:0034968)2.85700481
63histone H3-K36 demethylation (GO:0070544)2.82855535
64antigen processing and presentation via MHC class Ib (GO:0002475)2.82602647
65histone H3-K4 methylation (GO:0051568)2.79264201
66protein localization to Golgi apparatus (GO:0034067)2.76344555
67negative regulation of neurotransmitter secretion (GO:0046929)2.76329315
68nucleus localization (GO:0051647)2.76318089
69negative regulation of neurotransmitter transport (GO:0051589)2.75887764
70leukocyte aggregation (GO:0070486)2.74291517
71response to muramyl dipeptide (GO:0032495)2.71809467
72negative regulation of cytosolic calcium ion concentration (GO:0051481)2.71284093
73monoubiquitinated protein deubiquitination (GO:0035520)2.71152726
74megakaryocyte development (GO:0035855)2.69077196
75central nervous system neuron axonogenesis (GO:0021955)2.68580380
76presynaptic membrane organization (GO:0097090)2.67628906
77snRNA transcription (GO:0009301)2.67221218
78positive thymic T cell selection (GO:0045059)2.66894948
79sodium ion export (GO:0071436)2.65140608
80hepatocyte apoptotic process (GO:0097284)2.63780950
81cell wall macromolecule catabolic process (GO:0016998)2.63533146
82cytoplasmic mRNA processing body assembly (GO:0033962)2.62050782
83neutrophil activation involved in immune response (GO:0002283)2.61781067
84protein localization to endosome (GO:0036010)2.61398601
85natural killer cell differentiation (GO:0001779)2.60947751
86B cell homeostasis (GO:0001782)2.59489628
87central nervous system projection neuron axonogenesis (GO:0021952)2.59487702
88germ cell migration (GO:0008354)2.59275689
89regulation of establishment or maintenance of cell polarity (GO:0032878)2.58318937
90thymic T cell selection (GO:0045061)2.57399086
91JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.57319724
92regulation of developmental pigmentation (GO:0048070)2.56375860
93pyrimidine nucleobase catabolic process (GO:0006208)2.55595941
94positive regulation of interferon-alpha production (GO:0032727)2.55156501
95myelin assembly (GO:0032288)2.55074320
96regulation of translational termination (GO:0006449)2.53995254
97oocyte development (GO:0048599)2.53708008
98growth hormone receptor signaling pathway (GO:0060396)2.52094452
99Golgi to endosome transport (GO:0006895)2.51548303
100positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.50685907
101cortical cytoskeleton organization (GO:0030865)2.49961680
102regulation of NFAT protein import into nucleus (GO:0051532)2.48884720
103negative regulation of calcium ion transport into cytosol (GO:0010523)2.48018597
104positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.47555863
105regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.47555863
106nerve growth factor signaling pathway (GO:0038180)2.47117477
107otic vesicle formation (GO:0030916)2.45343901
108appendage development (GO:0048736)2.44989105
109limb development (GO:0060173)2.44989105
110DNA double-strand break processing (GO:0000729)2.44748199
111positive regulation of granulocyte differentiation (GO:0030854)2.44171467
112protein K63-linked deubiquitination (GO:0070536)2.43936105
113positive regulation of DNA-templated transcription, initiation (GO:2000144)2.43882984
114positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.43304337
115regulation of sarcomere organization (GO:0060297)2.42343240
116histone H2A acetylation (GO:0043968)2.41465038
117positive regulation of Rap GTPase activity (GO:0032854)2.40536407
118regulation of interferon-alpha production (GO:0032647)2.40391320
119myeloid cell activation involved in immune response (GO:0002275)2.40053646
120leukocyte cell-cell adhesion (GO:0007159)2.39435701
121peptidyl-threonine phosphorylation (GO:0018107)2.38664951
122regulation of telomere maintenance (GO:0032204)2.38551980
123regulation of synapse structural plasticity (GO:0051823)2.37546564
124olfactory bulb development (GO:0021772)2.37169541
125negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.37142518
126regulation of isotype switching to IgG isotypes (GO:0048302)2.36837059
127T cell selection (GO:0045058)2.36663987
128activation of JUN kinase activity (GO:0007257)2.35251499
129positive regulation of interferon-beta production (GO:0032728)2.35225919
130positive regulation of macrophage cytokine production (GO:0060907)2.34378154
131cellular extravasation (GO:0045123)2.33821319
132protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.33777935
133cellular response to sterol (GO:0036315)2.33635791
134embryonic hemopoiesis (GO:0035162)2.33436028
135positive regulation of protein deacetylation (GO:0090312)2.30756104
136peptidyl-threonine modification (GO:0018210)2.30427727
137interferon-gamma-mediated signaling pathway (GO:0060333)2.29587782
138sexual reproduction (GO:0019953)2.29394161
139T cell costimulation (GO:0031295)2.29350335
140negative regulation of B cell proliferation (GO:0030889)2.28105181
141NIK/NF-kappaB signaling (GO:0038061)2.27957838
142regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.27788968
143negative regulation of fatty acid transport (GO:2000192)2.27492233
144natural killer cell mediated immunity (GO:0002228)2.27242683
145natural killer cell mediated cytotoxicity (GO:0042267)2.27242683
146detection of mechanical stimulus involved in sensory perception (GO:0050974)2.26913403
147regulation of defense response to virus by virus (GO:0050690)2.26717439
148lymphocyte costimulation (GO:0031294)2.26605557
149regulation of Rac protein signal transduction (GO:0035020)2.25769194
150immunoglobulin mediated immune response (GO:0016064)2.25717161
151rRNA catabolic process (GO:0016075)2.25654639
152regulation of macrophage cytokine production (GO:0010935)2.25284353
153nuclear pore complex assembly (GO:0051292)2.24271322
154cAMP catabolic process (GO:0006198)2.24160771
155positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.23883236
156protein localization to cilium (GO:0061512)2.23545050
157cerebellar Purkinje cell differentiation (GO:0021702)2.23476879
158Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.23251359
159immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.23251359
160Fc-gamma receptor signaling pathway (GO:0038094)2.23251359
161detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.23068135
162regulation of growth hormone secretion (GO:0060123)2.23011352
163cardiovascular system development (GO:0072358)2.22298504
164Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.21780840
165cytoskeletal anchoring at plasma membrane (GO:0007016)2.19794527
166single strand break repair (GO:0000012)2.19357129
167SMAD protein complex assembly (GO:0007183)2.19112516
168vesicle transport along microtubule (GO:0047496)2.19021235
169corticosteroid receptor signaling pathway (GO:0031958)2.18701908
170layer formation in cerebral cortex (GO:0021819)2.18501446
171regulation of posttranscriptional gene silencing (GO:0060147)2.18111574
172regulation of gene silencing by miRNA (GO:0060964)2.18111574
173regulation of gene silencing by RNA (GO:0060966)2.18111574
174I-kappaB phosphorylation (GO:0007252)2.17727067
175positive regulation of mRNA catabolic process (GO:0061014)2.17640214
176peptidyl-serine phosphorylation (GO:0018105)2.17559511
177macroautophagy (GO:0016236)2.17052774
178regulation of nucleobase-containing compound transport (GO:0032239)2.15934230
179replication fork processing (GO:0031297)2.15698554
180cyclic nucleotide catabolic process (GO:0009214)2.15196097
181regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.14893741
182positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.14893741
183protein localization to kinetochore (GO:0034501)2.14646634
184cell wall macromolecule metabolic process (GO:0044036)2.14408070
185organ growth (GO:0035265)2.14372410
186centriole replication (GO:0007099)2.14210846
187positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.14199986
188indolalkylamine metabolic process (GO:0006586)2.13875106
189positive regulation of histone H3-K4 methylation (GO:0051571)2.13510767
190mitotic sister chromatid cohesion (GO:0007064)2.13492942
191intraciliary transport (GO:0042073)2.13196094
192retrograde transport, vesicle recycling within Golgi (GO:0000301)2.13097480
193regulation of MHC class II biosynthetic process (GO:0045346)2.12167446
194myeloid cell development (GO:0061515)2.11647347
195epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.11403114

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.97114751
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.90034277
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.59565722
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.56682751
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.54788917
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.15858347
7MYC_22102868_ChIP-Seq_BL_Human3.10933585
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.09958417
9GBX2_23144817_ChIP-Seq_PC3_Human3.09772150
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.99031953
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.91529671
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.90111004
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.70264653
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.68152049
15ZNF274_21170338_ChIP-Seq_K562_Hela2.63213885
16TCF7_22412390_ChIP-Seq_EML_Mouse2.56860760
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56263974
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.54862429
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54160758
20RUNX_20019798_ChIP-Seq_JUKART_Human2.48771142
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.45187133
22TAF15_26573619_Chip-Seq_HEK293_Human2.40761532
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38070972
24SPI1_23127762_ChIP-Seq_K562_Human2.36083060
25FUS_26573619_Chip-Seq_HEK293_Human2.30965081
26KDM2B_26808549_Chip-Seq_DND41_Human2.28912572
27VDR_21846776_ChIP-Seq_THP-1_Human2.28120308
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.28020359
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.27966829
30KDM2B_26808549_Chip-Seq_SUP-B15_Human2.27641771
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.26622736
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25931926
33BP1_19119308_ChIP-ChIP_Hs578T_Human2.25408235
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.25084846
35IGF1R_20145208_ChIP-Seq_DFB_Human2.23082243
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.18108846
37VDR_22108803_ChIP-Seq_LS180_Human2.15458281
38SCL_19346495_ChIP-Seq_HPC-7_Human2.12002925
39MAF_26560356_Chip-Seq_TH1_Human2.11736168
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.09358512
41FLI1_27457419_Chip-Seq_LIVER_Mouse2.08274344
42P300_19829295_ChIP-Seq_ESCs_Human2.05614741
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.02732738
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.01208508
45EWS_26573619_Chip-Seq_HEK293_Human2.00971512
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.99311154
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.96575038
48MYB_26560356_Chip-Seq_TH2_Human1.95460264
49UTX_26944678_Chip-Seq_JUKART_Human1.92964409
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.91112128
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89800853
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.88261554
53SMAD4_21799915_ChIP-Seq_A2780_Human1.87773041
54STAT3_23295773_ChIP-Seq_U87_Human1.87255221
55GATA1_22025678_ChIP-Seq_K562_Human1.86609836
56VDR_24763502_ChIP-Seq_THP-1_Human1.86262380
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.81675685
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.80686207
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76566867
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.76566867
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74940937
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.73776026
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72763518
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.71952660
65TP53_16413492_ChIP-PET_HCT116_Human1.71754638
66ER_23166858_ChIP-Seq_MCF-7_Human1.71177371
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.70791724
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69043171
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.68572334
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67670070
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.67433083
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64079083
73MYB_26560356_Chip-Seq_TH1_Human1.62769157
74TCF4_23295773_ChIP-Seq_U87_Human1.62660916
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.62565811
76TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.59534699
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59057651
78EZH2_22144423_ChIP-Seq_EOC_Human1.58982539
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58697700
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.58465746
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58431821
82OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57953799
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56676436
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54829450
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53490538
86AR_21572438_ChIP-Seq_LNCaP_Human1.53044171
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52956119
88GATA1_19941827_ChIP-Seq_MEL_Mouse1.52100530
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51984250
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.51747788
91ELK3_25401928_ChIP-Seq_HUVEC_Human1.50557515
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49142501
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48923978
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48460801
95GATA1_19941826_ChIP-Seq_K562_Human1.48154608
96FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47345552
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.47344809
98GATA3_27048872_Chip-Seq_THYMUS_Human1.46898961
99ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46326427
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.45082781
101EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44764811
102CBP_20019798_ChIP-Seq_JUKART_Human1.44682850
103IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44682850
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43888492
105AR_25329375_ChIP-Seq_VCAP_Human1.42561209
106PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42269955
107PU_27001747_Chip-Seq_BMDM_Mouse1.41598818
108BCAT_22108803_ChIP-Seq_LS180_Human1.40565435
109PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40135612
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.39856842
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.35776168
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35360101
113SPI1_23547873_ChIP-Seq_NB4_Human1.33868811
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.33254525
115HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30908783
116DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30891112
117RUNX2_22187159_ChIP-Seq_PCA_Human1.30471766
118AHR_22903824_ChIP-Seq_MCF-7_Human1.30323617
119RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29249293
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28869388
121KDM2B_26808549_Chip-Seq_K562_Human1.28773509
122NFE2_27457419_Chip-Seq_LIVER_Mouse1.28617428
123GATA2_21666600_ChIP-Seq_HMVEC_Human1.27278419
124E2F1_18555785_Chip-Seq_ESCs_Mouse1.27105559
125PRDM14_20953172_ChIP-Seq_ESCs_Human1.27043695
126GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26466000
127STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26331191
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25467294
129THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23920489
130KDM2B_26808549_Chip-Seq_REH_Human1.23459986
131TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.23111407
132P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22507279
133HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21014128
134KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19855720
135MAF_26560356_Chip-Seq_TH2_Human1.19141834
136GATA2_19941826_ChIP-Seq_K562_Human1.17031399
137SOX2_21211035_ChIP-Seq_LN229_Gbm1.16532802
138TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15306313
139DROSHA_22980978_ChIP-Seq_HELA_Human1.15048273
140CRX_20693478_ChIP-Seq_RETINA_Mouse1.14277317
141P53_22387025_ChIP-Seq_ESCs_Mouse1.13945251
142OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13874196
143CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13793088
144ZNF263_19887448_ChIP-Seq_K562_Human1.13110397
145TCF4_22108803_ChIP-Seq_LS180_Human1.12826522
146KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12809743
147NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12750563
148NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12750563
149CMYC_18555785_Chip-Seq_ESCs_Mouse1.12698492
150VDR_24787735_ChIP-Seq_THP-1_Human1.12525955
151FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.11342665
152SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10891635
153TP63_19390658_ChIP-ChIP_HaCaT_Human1.10760095
154NOTCH1_21737748_ChIP-Seq_TLL_Human1.10746424
155EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10442306
156PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09412071
157FOXO3_23340844_ChIP-Seq_DLD1_Human1.09242914
158CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08496391
159RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08375850
160CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08204729
161RARB_27405468_Chip-Seq_BRAIN_Mouse1.07598149
162RXR_22108803_ChIP-Seq_LS180_Human1.05757140
163FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05268004
164LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05240196
165MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04803564
166P300_18555785_Chip-Seq_ESCs_Mouse1.04423701
167CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03873189
168TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03838266
169WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03600828
170KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03416268
171STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02920681
172NCOR1_26117541_ChIP-Seq_K562_Human1.01713309
173MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01273827
174SMAD4_21741376_ChIP-Seq_EPCs_Human1.01134647
175ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00793494
176EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00290276
177LXR_22292898_ChIP-Seq_THP-1_Human0.99496394
178RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97563321
179GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96555449
180GATA3_26560356_Chip-Seq_TH2_Human0.96305497
181ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96165604
182SMAD_19615063_ChIP-ChIP_OVARY_Human0.95024622
183TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95016981
184CLOCK_20551151_ChIP-Seq_293T_Human0.94567979
185GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92036434
186RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91717312
187STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89258268
188TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88979652
189CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85985271
190TBX20_22080862_ChIP-Seq_HEART_Mouse0.82735808
191TBX20_22328084_ChIP-Seq_HEART_Mouse0.82735808
192LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81901730
193KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81586694
194TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80121647

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.75655868
2MP0000569_abnormal_digit_pigmentation4.32827903
3MP0003890_abnormal_embryonic-extraembry3.37545996
4MP0003303_peritoneal_inflammation3.36191962
5MP0001835_abnormal_antigen_presentation3.26773146
6MP0000383_abnormal_hair_follicle2.70943510
7MP0004510_myositis2.61169873
8MP0004859_abnormal_synaptic_plasticity2.48234789
9MP0008877_abnormal_DNA_methylation2.31583518
10MP0002009_preneoplasia2.26733507
11MP0003300_gastrointestinal_ulcer2.25821669
12MP0001800_abnormal_humoral_immune2.21774236
13MP0000685_abnormal_immune_system2.20986545
14MP0005671_abnormal_response_to2.19547439
15MP0003646_muscle_fatigue2.18766479
16MP0000372_irregular_coat_pigmentation2.17943191
17MP0010678_abnormal_skin_adnexa2.16765184
18MP0003172_abnormal_lysosome_physiology2.16560286
19MP0001790_abnormal_immune_system2.16175392
20MP0005387_immune_system_phenotype2.16175392
21MP0005076_abnormal_cell_differentiation2.15402775
22MP0010352_gastrointestinal_tract_polyps2.14444636
23MP0000427_abnormal_hair_cycle2.14414524
24MP0002877_abnormal_melanocyte_morpholog2.12076159
25MP0002452_abnormal_antigen_presenting2.08785118
26MP0003436_decreased_susceptibility_to2.01913469
27MP0002419_abnormal_innate_immunity1.98912302
28MP0002166_altered_tumor_susceptibility1.96729518
29MP0005464_abnormal_platelet_physiology1.96509383
30MP0005000_abnormal_immune_tolerance1.92082202
31MP0003195_calcinosis1.91840628
32MP0003705_abnormal_hypodermis_morpholog1.91091820
33MP0002723_abnormal_immune_serum1.86856032
34MP0002420_abnormal_adaptive_immunity1.86100199
35MP0001819_abnormal_immune_cell1.85613827
36MP0003787_abnormal_imprinting1.84450287
37MP0002398_abnormal_bone_marrow1.84427503
38MP0009278_abnormal_bone_marrow1.83629798
39MP0004145_abnormal_muscle_electrophysio1.77576135
40MP0004808_abnormal_hematopoietic_stem1.74347366
41MP0000604_amyloidosis1.73666432
42MP0002006_tumorigenesis1.62127935
43MP0004947_skin_inflammation1.60989026
44MP0000716_abnormal_immune_system1.58844285
45MP0005025_abnormal_response_to1.53805829
46MP0004130_abnormal_muscle_cell1.49997897
47MP0002396_abnormal_hematopoietic_system1.49669987
48MP0003191_abnormal_cellular_cholesterol1.48012978
49MP0005397_hematopoietic_system_phenotyp1.47561199
50MP0001545_abnormal_hematopoietic_system1.47561199
51MP0002168_other_aberrant_phenotype1.47548249
52MP0003075_altered_response_to1.47255014
53MP0005058_abnormal_lysosome_morphology1.47019435
54MP0005645_abnormal_hypothalamus_physiol1.46712756
55MP0008961_abnormal_basal_metabolism1.46569264
56MP0000778_abnormal_nervous_system1.44588366
57MP0000689_abnormal_spleen_morphology1.43357572
58MP0009840_abnormal_foam_cell1.43022409
59MP0003763_abnormal_thymus_physiology1.40534271
60MP0003690_abnormal_glial_cell1.40531030
61MP0005075_abnormal_melanosome_morpholog1.40044845
62MP0003950_abnormal_plasma_membrane1.39486875
63MP0002405_respiratory_system_inflammati1.39101987
64MP0005248_abnormal_Harderian_gland1.37462585
65MP0003183_abnormal_peptide_metabolism1.37332518
66MP0002138_abnormal_hepatobiliary_system1.36161033
67MP0010307_abnormal_tumor_latency1.35483110
68MP0009785_altered_susceptibility_to1.35114238
69MP0000015_abnormal_ear_pigmentation1.34589994
70MP0005253_abnormal_eye_physiology1.34254790
71MP0002638_abnormal_pupillary_reflex1.33536765
72MP0002722_abnormal_immune_system1.33387270
73MP0001501_abnormal_sleep_pattern1.33073524
74MP0002429_abnormal_blood_cell1.32715121
75MP0006082_CNS_inflammation1.31898024
76MP0003329_amyloid_beta_deposits1.29052139
77MP0004043_abnormal_pH_regulation1.28913834
78MP0003448_altered_tumor_morphology1.27715652
79MP0003045_fibrosis1.26511881
80MP0003937_abnormal_limbs/digits/tail_de1.24436767
81MP0003091_abnormal_cell_migration1.24218801
82MP0004381_abnormal_hair_follicle1.24112231
83MP0001486_abnormal_startle_reflex1.23551098
84MP0005551_abnormal_eye_electrophysiolog1.22707124
85MP0005310_abnormal_salivary_gland1.22007671
86MP0000371_diluted_coat_color1.21316738
87MP0002751_abnormal_autonomic_nervous1.20708390
88MP0000703_abnormal_thymus_morphology1.18808791
89MP0001984_abnormal_olfaction1.17952173
90MP0001533_abnormal_skeleton_physiology1.16824215
91MP0003121_genomic_imprinting1.16230948
92MP0001845_abnormal_inflammatory_respons1.15667232
93MP0003566_abnormal_cell_adhesion1.15665497
94MP0002148_abnormal_hypersensitivity_rea1.12939683
95MP0000631_abnormal_neuroendocrine_gland1.12221300
96MP0002102_abnormal_ear_morphology1.10993060
97MP0005187_abnormal_penis_morphology1.09926194
98MP0005166_decreased_susceptibility_to1.09348078
99MP0002837_dystrophic_cardiac_calcinosis1.06511635
100MP0005623_abnormal_meninges_morphology1.06182286
101MP0000733_abnormal_muscle_development1.05982165
102MP0000465_gastrointestinal_hemorrhage1.05838196
103MP0001299_abnormal_eye_distance/1.04847484
104MP0000920_abnormal_myelination1.03671138
105MP0005646_abnormal_pituitary_gland1.03341145
106MP0004084_abnormal_cardiac_muscle1.03296924
107MP0003880_abnormal_central_pattern1.03076924
108MP0010155_abnormal_intestine_physiology1.03060347
109MP0004142_abnormal_muscle_tone1.02257320
110MP0005379_endocrine/exocrine_gland_phen1.01993315
111MP0005386_behavior/neurological_phenoty1.01954632
112MP0004924_abnormal_behavior1.01954632
113MP0001873_stomach_inflammation1.01863770
114MP0000647_abnormal_sebaceous_gland1.01773314
115MP0006292_abnormal_olfactory_placode1.01258308
116MP0004484_altered_response_of0.99930138
117MP0000428_abnormal_craniofacial_morphol0.98095885
118MP0004858_abnormal_nervous_system0.95133846
119MP0001915_intracranial_hemorrhage0.94911839
120MP0002067_abnormal_sensory_capabilities0.94584121
121MP0009697_abnormal_copulation0.94468605
122MP0002998_abnormal_bone_remodeling0.93222504
123MP0002233_abnormal_nose_morphology0.89819154
124MP0001348_abnormal_lacrimal_gland0.89803912
125MP0004811_abnormal_neuron_physiology0.88238530
126MP0006054_spinal_hemorrhage0.87712393
127MP0003656_abnormal_erythrocyte_physiolo0.87648612
128MP0000858_altered_metastatic_potential0.87642021
129MP0008569_lethality_at_weaning0.87010043
130MP0005499_abnormal_olfactory_system0.84441416
131MP0005394_taste/olfaction_phenotype0.84441416
132MP0004197_abnormal_fetal_growth/weight/0.84424178
133MP0003943_abnormal_hepatobiliary_system0.82673273
134MP0005621_abnormal_cell_physiology0.82371268
135MP0002095_abnormal_skin_pigmentation0.81997392
136MP0004036_abnormal_muscle_relaxation0.81796361
137MP0009703_decreased_birth_body0.81729136
138MP0004134_abnormal_chest_morphology0.81382178
139MP0001851_eye_inflammation0.81011020
140MP0006072_abnormal_retinal_apoptosis0.79159810
141MP0002090_abnormal_vision0.78425992
142MP0001853_heart_inflammation0.77568058
143MP0003635_abnormal_synaptic_transmissio0.77536247
144MP0000955_abnormal_spinal_cord0.77333501
145MP0003866_abnormal_defecation0.77305981
146MP0003136_yellow_coat_color0.76529486
147MP0005395_other_phenotype0.76503156
148MP0005167_abnormal_blood-brain_barrier0.75638425
149MP0003935_abnormal_craniofacial_develop0.75558142
150MP0001286_abnormal_eye_development0.75402039
151MP0005023_abnormal_wound_healing0.75378962
152MP0005174_abnormal_tail_pigmentation0.74692340
153MP0009333_abnormal_splenocyte_physiolog0.74512427
154MP0009745_abnormal_behavioral_response0.74116466
155MP0005391_vision/eye_phenotype0.74056887
156MP0002332_abnormal_exercise_endurance0.73294690
157MP0003633_abnormal_nervous_system0.72990381
158MP0009115_abnormal_fat_cell0.72922174
159MP0002735_abnormal_chemical_nociception0.72773807
160MP0002229_neurodegeneration0.72690837
161MP0008469_abnormal_protein_level0.72343127
162MP0004185_abnormal_adipocyte_glucose0.71948628
163MP0004215_abnormal_myocardial_fiber0.71299803
164MP0001177_atelectasis0.70740914
165MP0002184_abnormal_innervation0.69904899
166MP0002272_abnormal_nervous_system0.69520221
167MP0003632_abnormal_nervous_system0.69455632
168MP0008058_abnormal_DNA_repair0.69242293
169MP0006276_abnormal_autonomic_nervous0.68415325
170MP0002928_abnormal_bile_duct0.68053843
171MP0005266_abnormal_metabolism0.67722867
172MP0003634_abnormal_glial_cell0.67219354
173MP0001968_abnormal_touch/_nociception0.66884221
174MP0001485_abnormal_pinna_reflex0.65652961
175MP0002557_abnormal_social/conspecific_i0.65512168
176MP0010386_abnormal_urinary_bladder0.65190539
177MP0003631_nervous_system_phenotype0.64290357
178MP0009046_muscle_twitch0.62971508
179MP0002019_abnormal_tumor_incidence0.61030052
180MP0010630_abnormal_cardiac_muscle0.60900088

Predicted human phenotypes

RankGene SetZ-score
1Intestinal atresia (HP:0011100)3.96177720
2Gaze-evoked nystagmus (HP:0000640)3.36766578
3Recurrent viral infections (HP:0004429)3.31336838
4Chronic hepatic failure (HP:0100626)3.24344912
5Papillary thyroid carcinoma (HP:0002895)3.18179402
6Recurrent abscess formation (HP:0002722)3.15302660
7Protruding tongue (HP:0010808)3.14764960
8Recurrent bacterial skin infections (HP:0005406)3.11477669
9Hyperventilation (HP:0002883)3.11248510
10Chronic otitis media (HP:0000389)3.10393362
11Submucous cleft hard palate (HP:0000176)3.08481563
12Chin dimple (HP:0010751)3.08308641
13Disinhibition (HP:0000734)2.99288879
14Volvulus (HP:0002580)2.96090706
15Increased cerebral lipofuscin (HP:0011813)2.95924052
16Genetic anticipation (HP:0003743)2.94685276
17Widely spaced teeth (HP:0000687)2.94500941
18Recurrent fungal infections (HP:0002841)2.90118801
19Aqueductal stenosis (HP:0002410)2.85743553
20Pancreatic cysts (HP:0001737)2.84960997
21Cellulitis (HP:0100658)2.84494616
22Abnormality of the fingertips (HP:0001211)2.84066391
23Cerebral aneurysm (HP:0004944)2.74212038
24Eczematoid dermatitis (HP:0000976)2.73269265
25Febrile seizures (HP:0002373)2.69658462
26Supranuclear gaze palsy (HP:0000605)2.67402799
27Keratoconus (HP:0000563)2.60483114
28Increased corneal curvature (HP:0100692)2.60483114
29Abnormality of the renal cortex (HP:0011035)2.58926521
30Colitis (HP:0002583)2.57721153
31Progressive cerebellar ataxia (HP:0002073)2.57011718
32Nephronophthisis (HP:0000090)2.56658787
33Abnormal hair whorl (HP:0010721)2.56194004
34Fair hair (HP:0002286)2.53432801
35Tubulointerstitial nephritis (HP:0001970)2.52025328
36Macroorchidism (HP:0000053)2.50883601
37Hyperacusis (HP:0010780)2.49899654
38Broad-based gait (HP:0002136)2.49722004
39Abnormality of the renal medulla (HP:0100957)2.48810767
40Myositis (HP:0100614)2.42667250
41Fatigue (HP:0012378)2.38261312
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.36538601
43Agammaglobulinemia (HP:0004432)2.35915872
44Papilledema (HP:0001085)2.35575587
45Truncal obesity (HP:0001956)2.34227296
46Papilloma (HP:0012740)2.32542298
47Verrucae (HP:0200043)2.32542298
48Drooling (HP:0002307)2.31733329
49Cupped ear (HP:0000378)2.31218549
50Elevated erythrocyte sedimentation rate (HP:0003565)2.30683900
51True hermaphroditism (HP:0010459)2.29485611
52Recurrent skin infections (HP:0001581)2.26329030
53Inappropriate behavior (HP:0000719)2.26296646
54Pancreatic fibrosis (HP:0100732)2.23671208
55Interstitial pulmonary disease (HP:0006530)2.21840470
56Lower limb amyotrophy (HP:0007210)2.21731104
57Overlapping toe (HP:0001845)2.21171186
58Dilatation of the ascending aorta (HP:0005111)2.19445616
59Absent speech (HP:0001344)2.18059410
60Molar tooth sign on MRI (HP:0002419)2.17813352
61Abnormality of midbrain morphology (HP:0002418)2.17813352
62Tented upper lip vermilion (HP:0010804)2.16893679
63Viral hepatitis (HP:0006562)2.16389161
64Medial flaring of the eyebrow (HP:0010747)2.15780064
65Cerebellar dysplasia (HP:0007033)2.15522293
66Mutism (HP:0002300)2.14776494
67Excessive salivation (HP:0003781)2.13725117
68Poor coordination (HP:0002370)2.13128799
69Subaortic stenosis (HP:0001682)2.12026379
70Abnormality of the left ventricular outflow tract (HP:0011103)2.12026379
71Facial diplegia (HP:0001349)2.11678784
72Panhypogammaglobulinemia (HP:0003139)2.10591761
73Arterial tortuosity (HP:0005116)2.10085686
74Tubular atrophy (HP:0000092)2.09131663
75Mitral valve prolapse (HP:0001634)2.08874441
76Recurrent cutaneous fungal infections (HP:0011370)2.08488538
77Chronic mucocutaneous candidiasis (HP:0002728)2.08488538
78Short chin (HP:0000331)2.07771757
79Abnormality of macrophages (HP:0004311)2.07680743
80Mediastinal lymphadenopathy (HP:0100721)2.05427300
81Aortic aneurysm (HP:0004942)2.04493201
82Thyroid carcinoma (HP:0002890)2.03802412
83Abnormality of the ischium (HP:0003174)2.03424736
84Heterotopia (HP:0002282)2.03418678
85Frequent falls (HP:0002359)2.03251994
86Attenuation of retinal blood vessels (HP:0007843)2.03137325
87Cutaneous melanoma (HP:0012056)2.01678627
88Gastrointestinal atresia (HP:0002589)2.01674711
89Apathy (HP:0000741)2.01427701
90Distal arthrogryposis (HP:0005684)1.99816973
91Inflammation of the large intestine (HP:0002037)1.97171698
92Thyroiditis (HP:0100646)1.96884174
93Bony spicule pigmentary retinopathy (HP:0007737)1.96763518
94Gait imbalance (HP:0002141)1.96464212
95Focal seizures (HP:0007359)1.95945194
96Dysmetric saccades (HP:0000641)1.95233152
97Congenital primary aphakia (HP:0007707)1.95155730
98Clumsiness (HP:0002312)1.94030816
99Recurrent gram-negative bacterial infections (HP:0005420)1.93888694
100Gastrointestinal inflammation (HP:0004386)1.93821327
101Hypoplastic ischia (HP:0003175)1.93094363
102Hypoplastic iliac wings (HP:0002866)1.92647860
103Recurrent bronchitis (HP:0002837)1.92641483
104Urinary urgency (HP:0000012)1.92559456
105Distal upper limb amyotrophy (HP:0007149)1.92316356
106Upper limb amyotrophy (HP:0009129)1.92316356
107Dandy-Walker malformation (HP:0001305)1.92067549
108Genital tract atresia (HP:0001827)1.92044842
109Oligodactyly (hands) (HP:0001180)1.91758631
110Postural instability (HP:0002172)1.91709287
111Arterial thrombosis (HP:0004420)1.91471415
112Striae distensae (HP:0001065)1.90873906
113Neoplasm of the adrenal cortex (HP:0100641)1.90471341
114Hand muscle atrophy (HP:0009130)1.90094490
115Stomach cancer (HP:0012126)1.89324980
116Autoimmune thrombocytopenia (HP:0001973)1.89288166
117Clubbing of toes (HP:0100760)1.89051679
118Renal cortical cysts (HP:0000803)1.88682314
119Generalized hypopigmentation of hair (HP:0011358)1.88538306
120Hematochezia (HP:0002573)1.87937180
121Thoracolumbar scoliosis (HP:0002944)1.87897036
122Acute lymphatic leukemia (HP:0006721)1.87220278
123Abnormality of incisor morphology (HP:0011063)1.86668419
124Gingival bleeding (HP:0000225)1.86399135
125Mitral stenosis (HP:0001718)1.86083312
126Centrally nucleated skeletal muscle fibers (HP:0003687)1.85935553
127Sandal gap (HP:0001852)1.85768088
128Vaginal atresia (HP:0000148)1.85674849
129Vasculitis (HP:0002633)1.85053884
130Amyotrophic lateral sclerosis (HP:0007354)1.84277866
131Acute myeloid leukemia (HP:0004808)1.84138211
132Nephrogenic diabetes insipidus (HP:0009806)1.82833497
133Medulloblastoma (HP:0002885)1.82775126
134Diminished motivation (HP:0000745)1.81907839
135Nasal polyposis (HP:0100582)1.81889428
136Progressive inability to walk (HP:0002505)1.81881451
137Aplasia/Hypoplasia of the tibia (HP:0005772)1.81695209
138Abnormality of liposaccharide metabolism (HP:0010968)1.81099895
139Abnormality of glycosphingolipid metabolism (HP:0004343)1.81099895
140Abnormality of glycolipid metabolism (HP:0010969)1.81099895
141Vascular tortuosity (HP:0004948)1.80106623
142Loss of speech (HP:0002371)1.79683104
143Abnormality of chromosome stability (HP:0003220)1.78977104
144Chest pain (HP:0100749)1.78114728
145Embryonal renal neoplasm (HP:0011794)1.77880808
146Cortical dysplasia (HP:0002539)1.77103828
147Hip dysplasia (HP:0001385)1.77074776
148Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.77059725
149Difficulty running (HP:0009046)1.76843481
150Orchitis (HP:0100796)1.76829227
151Dialeptic seizures (HP:0011146)1.76356265
152Astigmatism (HP:0000483)1.76075385
153Absent frontal sinuses (HP:0002688)1.76067347
154Ectopic kidney (HP:0000086)1.76064549
155Cutaneous finger syndactyly (HP:0010554)1.75022439
156Subacute progressive viral hepatitis (HP:0006572)1.74938168
157Abnormal platelet volume (HP:0011876)1.74864943
158Pointed chin (HP:0000307)1.74845822
159Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.74688270
160Spondylolisthesis (HP:0003302)1.74640024
161Distal lower limb amyotrophy (HP:0008944)1.73756206
162Hypoplastic labia majora (HP:0000059)1.73692763
163Rhabdomyosarcoma (HP:0002859)1.73517836
164Cerebral inclusion bodies (HP:0100314)1.73492552
165Neuronal loss in central nervous system (HP:0002529)1.73214683
166Increased mean platelet volume (HP:0011877)1.73030029
167Transitional cell carcinoma of the bladder (HP:0006740)1.72905013
168Hepatoblastoma (HP:0002884)1.72817050
169T lymphocytopenia (HP:0005403)1.72716995
170Short foot (HP:0001773)1.72623968
171Tubulointerstitial abnormality (HP:0001969)1.72026350
172Action tremor (HP:0002345)1.71994894
173Resting tremor (HP:0002322)1.71381788
174Insomnia (HP:0100785)1.70911688
175Abnormal delayed hypersensitivity skin test (HP:0002963)1.70630113
176Adactyly (HP:0009776)1.70599997
177Gastrointestinal stroma tumor (HP:0100723)1.70589776
178Nephroblastoma (Wilms tumor) (HP:0002667)1.70456665
179Highly arched eyebrow (HP:0002553)1.69676519
180Type II lissencephaly (HP:0007260)1.69145563
181Bladder carcinoma (HP:0002862)1.69124348
182Bladder neoplasm (HP:0009725)1.69124348
183Urinary bladder sphincter dysfunction (HP:0002839)1.69035321
184Renal hypoplasia (HP:0000089)1.68871972
185Osteolytic defects of the hand bones (HP:0009699)1.68666266
186Osteolytic defects of the phalanges of the hand (HP:0009771)1.68666266
187Hemiplegia (HP:0002301)1.68086143
188Atonic seizures (HP:0010819)1.66635138
189Abnormality of the labia majora (HP:0012881)1.65687509
190Periodontitis (HP:0000704)1.65408535
191Meningitis (HP:0001287)1.64453215
192Growth hormone deficiency (HP:0000824)1.64167908
193Neoplasm of striated muscle (HP:0009728)1.64030055
194Myocardial infarction (HP:0001658)1.62617789
195Abnormality of T cell number (HP:0011839)1.61254935
196Retrobulbar optic neuritis (HP:0100654)1.59992597
197Optic neuritis (HP:0100653)1.59992597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.67658273
2TRIB33.42813115
3MAP4K13.34430833
4ACVR1B3.22362864
5BMPR1B3.20193563
6BRD42.66831304
7PKN22.62863100
8MAP3K102.61792612
9MKNK22.43959998
10TNIK2.41464979
11EEF2K2.33497633
12CASK2.33441148
13MAP3K92.22732659
14AKT32.17727828
15EPHB12.03155135
16RIPK11.98304595
17TBK11.96911613
18NEK91.95082132
19RIPK41.92148695
20MAPK131.86695332
21STK101.82166992
22MAP4K21.74295323
23SGK21.73002571
24ICK1.70536013
25TYK21.65937304
26WNK31.64828514
27SIK21.61445074
28JAK11.60908610
29ERBB31.60045105
30MELK1.58902183
31OBSCN1.56005429
32CSF1R1.54053349
33STK38L1.53819102
34MAP3K131.51379047
35LRRK21.47512135
36NUAK11.46428844
37ALK1.42185943
38CAMKK11.41779535
39TTN1.41595646
40NLK1.41198709
41TRPM71.39164856
42FGFR21.35371502
43KIT1.34196531
44BRSK21.33892612
45RET1.33311686
46CAMK1G1.32607192
47KSR21.32441953
48ITK1.29055702
49CAMK1D1.29048170
50ERN11.28863089
51SCYL21.27324085
52PTK61.24551695
53PDK11.24274941
54PNCK1.23353558
55TGFBR11.23175778
56MKNK11.19796447
57FGFR41.17742239
58TEC1.17447222
59HCK1.15947502
60FGFR31.14815516
61SYK1.14242226
62BCR1.12222518
63INSRR1.11565480
64MARK11.09997988
65MAP3K141.09070351
66FES1.08848326
67JAK31.06235475
68TRIM281.06046293
69PIK3CG1.04367175
70PLK41.03795954
71ZAP701.01539228
72PINK11.01068649
73TAOK31.00730704
74GRK61.00079450
75SGK2230.98895861
76SGK4940.98895861
77PRKCH0.98487650
78TAOK10.98328113
79TGFBR20.97517456
80STK30.96373987
81ADRBK20.96290280
82TXK0.92989839
83WNK10.92628028
84LATS10.90479572
85CDK60.90050390
86MARK20.90022651
87IKBKE0.89807356
88JAK20.89479801
89PDGFRB0.85612874
90DMPK0.85241167
91PDK20.85035204
92FLT30.84832093
93PLK20.82807842
94MAP3K20.78239777
95SGK30.76394126
96OXSR10.76285060
97PDPK10.76216327
98NTRK30.75804437
99LCK0.75540541
100STK390.74665251
101EPHA30.74594863
102STK160.74239228
103BTK0.73245516
104PRKD30.73057938
105STK40.72708809
106CHUK0.72349064
107CAMK40.71297487
108PAK60.71297337
109DYRK1A0.70887569
110CDK120.69578701
111CSK0.69006660
112CSNK1A1L0.66987242
113DAPK20.64901728
114TYRO30.64266027
115MAP3K70.64213168
116PRKAA20.63255408
117PAK30.61787267
118FYN0.60888826
119IKBKB0.60697634
120STK240.59503335
121MINK10.58804358
122YES10.58791352
123SIK10.58040428
124WEE10.57286536
125ATM0.55792460
126PTK2B0.54837434
127CDK40.54619524
128RPS6KA20.54215284
129GRK10.53862151
130IRAK10.53253441
131FER0.53132359
132BMX0.53020607
133CDK30.52842699
134MAPK120.52728745
135CSNK1G20.52411130
136SGK10.52287591
137BLK0.52020807
138PRKCQ0.52014858
139MTOR0.51095723
140CSNK1G10.51033587
141FGFR10.50923449
142MAP2K70.50361419
143PRKCE0.49476508
144MAP2K30.48182632
145ZAK0.47656717
146EGFR0.47501908
147CAMKK20.47336596
148CSNK1D0.46629868
149STK110.44880808
150TAF10.44695480
151CLK10.43953691
152CDK50.43037212
153KSR10.43006248
154PDK40.42241238
155PDK30.42241238
156EIF2AK30.41727081
157MARK30.40687218
158MAP3K40.39784837
159NEK20.39608353
160PDGFRA0.39074508
161MATK0.38862711
162IRAK40.37682578
163RAF10.37623237
164MAP3K80.37364479
165PRKAA10.35484854
166PRKG10.34041233
167PKN10.33409374
168PIK3CA0.32813094
169ADRBK10.30024874

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.39635685
2Circadian rhythm_Homo sapiens_hsa047102.02672659
3Osteoclast differentiation_Homo sapiens_hsa043801.95125309
4Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.89886655
5Leishmaniasis_Homo sapiens_hsa051401.81808740
6Lysine degradation_Homo sapiens_hsa003101.81148041
7Phototransduction_Homo sapiens_hsa047441.80580868
8Non-homologous end-joining_Homo sapiens_hsa034501.77069388
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.64695662
10Chronic myeloid leukemia_Homo sapiens_hsa052201.59013823
11Neurotrophin signaling pathway_Homo sapiens_hsa047221.54962286
12mTOR signaling pathway_Homo sapiens_hsa041501.46863413
13Pancreatic cancer_Homo sapiens_hsa052121.46648035
14T cell receptor signaling pathway_Homo sapiens_hsa046601.43572464
15Non-small cell lung cancer_Homo sapiens_hsa052231.40932736
16Toxoplasmosis_Homo sapiens_hsa051451.40117113
17Taste transduction_Homo sapiens_hsa047421.38781123
18Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36843310
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.36838827
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36703635
21Glioma_Homo sapiens_hsa052141.35699228
22Chemokine signaling pathway_Homo sapiens_hsa040621.34605070
23Fanconi anemia pathway_Homo sapiens_hsa034601.33936973
24Dorso-ventral axis formation_Homo sapiens_hsa043201.33546644
25VEGF signaling pathway_Homo sapiens_hsa043701.32810675
26Platelet activation_Homo sapiens_hsa046111.31683892
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.30073118
28Glutamatergic synapse_Homo sapiens_hsa047241.28574311
29Tuberculosis_Homo sapiens_hsa051521.27952858
30Primary immunodeficiency_Homo sapiens_hsa053401.25377988
31Colorectal cancer_Homo sapiens_hsa052101.24654923
32Basal transcription factors_Homo sapiens_hsa030221.23467276
33Olfactory transduction_Homo sapiens_hsa047401.22949516
34Viral myocarditis_Homo sapiens_hsa054161.22910607
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22838662
36Antigen processing and presentation_Homo sapiens_hsa046121.21424999
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20816564
38Prostate cancer_Homo sapiens_hsa052151.20535385
39Renal cell carcinoma_Homo sapiens_hsa052111.19416809
40RNA degradation_Homo sapiens_hsa030181.18306870
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.17959547
42Type II diabetes mellitus_Homo sapiens_hsa049301.17448897
43Measles_Homo sapiens_hsa051621.17305267
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17074982
45Regulation of autophagy_Homo sapiens_hsa041401.17056079
46Long-term depression_Homo sapiens_hsa047301.14560964
47Nicotine addiction_Homo sapiens_hsa050331.14497195
48Acute myeloid leukemia_Homo sapiens_hsa052211.11889037
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11157887
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08700195
51Endocytosis_Homo sapiens_hsa041441.07211135
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07101833
53Pertussis_Homo sapiens_hsa051331.06476300
54Hepatitis B_Homo sapiens_hsa051611.04857525
55Calcium signaling pathway_Homo sapiens_hsa040201.04538501
56Estrogen signaling pathway_Homo sapiens_hsa049151.04262697
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03698506
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02977988
59TNF signaling pathway_Homo sapiens_hsa046681.02273102
60Shigellosis_Homo sapiens_hsa051311.02214308
61Apoptosis_Homo sapiens_hsa042101.00386631
62ABC transporters_Homo sapiens_hsa020100.99527223
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99400303
64Long-term potentiation_Homo sapiens_hsa047200.99142231
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98046294
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98008195
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97659891
68Influenza A_Homo sapiens_hsa051640.97252533
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96480829
70Endometrial cancer_Homo sapiens_hsa052130.96130821
71Salivary secretion_Homo sapiens_hsa049700.96043424
72Ether lipid metabolism_Homo sapiens_hsa005650.95426860
73Renin secretion_Homo sapiens_hsa049240.95283641
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93724337
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93137045
76Insulin secretion_Homo sapiens_hsa049110.91976320
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.91238681
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.91173213
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90911814
80Prolactin signaling pathway_Homo sapiens_hsa049170.90747116
81Amoebiasis_Homo sapiens_hsa051460.90390680
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89308290
83Salmonella infection_Homo sapiens_hsa051320.89261967
84Lysosome_Homo sapiens_hsa041420.89004704
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88769122
86Staphylococcus aureus infection_Homo sapiens_hsa051500.87978578
87Insulin resistance_Homo sapiens_hsa049310.87717924
88MAPK signaling pathway_Homo sapiens_hsa040100.86895161
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86709694
90cAMP signaling pathway_Homo sapiens_hsa040240.86385736
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.85134679
92Synaptic vesicle cycle_Homo sapiens_hsa047210.84200686
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.84122320
94TGF-beta signaling pathway_Homo sapiens_hsa043500.83493738
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.83455497
96Oxytocin signaling pathway_Homo sapiens_hsa049210.83418811
97Proteoglycans in cancer_Homo sapiens_hsa052050.83169804
98ErbB signaling pathway_Homo sapiens_hsa040120.83145800
99Legionellosis_Homo sapiens_hsa051340.83076601
100FoxO signaling pathway_Homo sapiens_hsa040680.80801395
101Dopaminergic synapse_Homo sapiens_hsa047280.80651434
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80365638
103Nitrogen metabolism_Homo sapiens_hsa009100.80253198
104Butanoate metabolism_Homo sapiens_hsa006500.80130438
105Morphine addiction_Homo sapiens_hsa050320.78978337
106Cholinergic synapse_Homo sapiens_hsa047250.78344203
107HIF-1 signaling pathway_Homo sapiens_hsa040660.77544147
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77515147
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.77185465
110Viral carcinogenesis_Homo sapiens_hsa052030.76276348
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.75389216
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74287259
113Serotonergic synapse_Homo sapiens_hsa047260.73717881
114Inositol phosphate metabolism_Homo sapiens_hsa005620.73314090
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72734088
116Small cell lung cancer_Homo sapiens_hsa052220.72612834
117Hedgehog signaling pathway_Homo sapiens_hsa043400.72199446
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72125926
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71947672
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.71418857
121Insulin signaling pathway_Homo sapiens_hsa049100.70304831
122Adherens junction_Homo sapiens_hsa045200.70119405
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70062068
124Choline metabolism in cancer_Homo sapiens_hsa052310.69627398
125GnRH signaling pathway_Homo sapiens_hsa049120.69089263
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68881911
127Ras signaling pathway_Homo sapiens_hsa040140.68299603
128mRNA surveillance pathway_Homo sapiens_hsa030150.68276598
129MicroRNAs in cancer_Homo sapiens_hsa052060.67919847
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67491605
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67481544
132p53 signaling pathway_Homo sapiens_hsa041150.66819022
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66751202
134Hepatitis C_Homo sapiens_hsa051600.66047424
135Fatty acid biosynthesis_Homo sapiens_hsa000610.65311646
136Melanoma_Homo sapiens_hsa052180.65037950
137Homologous recombination_Homo sapiens_hsa034400.64862440
138Propanoate metabolism_Homo sapiens_hsa006400.64827795
139Hematopoietic cell lineage_Homo sapiens_hsa046400.64768085
140Glycosaminoglycan degradation_Homo sapiens_hsa005310.64474426
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63309758
142Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63078931
143RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61404627
144Thyroid hormone synthesis_Homo sapiens_hsa049180.61375859
145Circadian entrainment_Homo sapiens_hsa047130.60658176
146GABAergic synapse_Homo sapiens_hsa047270.60636643
147Focal adhesion_Homo sapiens_hsa045100.60565329
148Glucagon signaling pathway_Homo sapiens_hsa049220.60256910
149Gastric acid secretion_Homo sapiens_hsa049710.60240293
150Herpes simplex infection_Homo sapiens_hsa051680.60209974

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