GPATCH3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)6.84764093
2regulation of retinoic acid receptor signaling pathway (GO:0048385)5.87173477
3folic acid-containing compound biosynthetic process (GO:0009396)4.03437606
4DNA deamination (GO:0045006)3.92412061
5folic acid metabolic process (GO:0046655)3.89898307
6protein localization to kinetochore (GO:0034501)3.88747350
7necroptotic process (GO:0070266)3.71998958
8protein localization to chromosome, centromeric region (GO:0071459)3.65064425
9negative regulation of cell killing (GO:0031342)3.59958868
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.59958868
11lipopolysaccharide-mediated signaling pathway (GO:0031663)3.55119608
12positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.44320153
13nucleobase biosynthetic process (GO:0046112)3.40473737
14tolerance induction (GO:0002507)3.39652164
15positive regulation of interleukin-17 production (GO:0032740)3.37471988
16T-helper 1 type immune response (GO:0042088)3.31059559
17mitotic nuclear envelope disassembly (GO:0007077)3.29065472
18neutrophil activation involved in immune response (GO:0002283)3.28531267
19mitotic metaphase plate congression (GO:0007080)3.23698445
20programmed necrotic cell death (GO:0097300)3.20433944
21sleep (GO:0030431)3.19164554
22purine nucleobase biosynthetic process (GO:0009113)3.16155799
23negative regulation of erythrocyte differentiation (GO:0045647)3.14370554
24positive regulation of endothelial cell apoptotic process (GO:2000353)3.13011422
253-UTR-mediated mRNA stabilization (GO:0070935)3.11732043
26formation of translation preinitiation complex (GO:0001731)3.09705178
27germinal center formation (GO:0002467)3.09681584
28cellular anion homeostasis (GO:0030002)3.09555811
29regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.07050993
30positive regulation of prostaglandin secretion (GO:0032308)3.06137005
31mitotic sister chromatid segregation (GO:0000070)3.05988880
32nuclear pore complex assembly (GO:0051292)3.05980502
33ribosome biogenesis (GO:0042254)3.05323409
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04271502
35mitotic chromosome condensation (GO:0007076)3.03774907
36nuclear envelope disassembly (GO:0051081)3.02789582
37membrane disassembly (GO:0030397)3.02789582
38regulation of mast cell degranulation (GO:0043304)3.02726098
39leukocyte apoptotic process (GO:0071887)3.02041532
40negative regulation of myeloid cell apoptotic process (GO:0033033)3.01732156
41regulation of hypersensitivity (GO:0002883)3.01211351
42regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.95800809
43nuclear pore organization (GO:0006999)2.95050923
44necrotic cell death (GO:0070265)2.93936081
45DNA replication-dependent nucleosome assembly (GO:0006335)2.93546748
46DNA replication-dependent nucleosome organization (GO:0034723)2.93546748
47positive regulation by symbiont of host defense response (GO:0052509)2.89989561
48modulation by symbiont of host defense response (GO:0052031)2.89989561
49modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.89989561
50modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.89989561
51positive regulation by organism of defense response of other organism involved in symbiotic interact2.89989561
52modulation by symbiont of host immune response (GO:0052553)2.89989561
53DNA replication initiation (GO:0006270)2.87823338
54regulation of spindle organization (GO:0090224)2.87204658
55T cell apoptotic process (GO:0070231)2.83994934
56leukocyte aggregation (GO:0070486)2.83044450
57natural killer cell mediated immunity (GO:0002228)2.82589747
58natural killer cell mediated cytotoxicity (GO:0042267)2.82589747
59negative regulation of type I interferon production (GO:0032480)2.81150110
60DNA replication checkpoint (GO:0000076)2.80899467
61negative regulation of histone methylation (GO:0031061)2.80336181
62maturation of SSU-rRNA (GO:0030490)2.80156417
63poly(A)+ mRNA export from nucleus (GO:0016973)2.80116798
64regulation of translational termination (GO:0006449)2.80097837
65negative regulation of cytokine production involved in immune response (GO:0002719)2.79298087
66pyrimidine nucleoside salvage (GO:0043097)2.76290018
67pyrimidine-containing compound salvage (GO:0008655)2.76290018
68positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.75671037
69positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.75492518
70negative regulation of interleukin-12 production (GO:0032695)2.73971846
71regulation of protein heterodimerization activity (GO:0043497)2.72704070
72response to muramyl dipeptide (GO:0032495)2.72025391
73DNA unwinding involved in DNA replication (GO:0006268)2.71386822
74negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.69583716
75negative regulation of innate immune response (GO:0045824)2.69381337
76positive regulation of NF-kappaB import into nucleus (GO:0042346)2.69360699
77IMP biosynthetic process (GO:0006188)2.69326991
78regulation of leukocyte degranulation (GO:0043300)2.67323626
79mRNA stabilization (GO:0048255)2.67092477
80RNA stabilization (GO:0043489)2.67092477
81regulation of mast cell activation involved in immune response (GO:0033006)2.66883734
82myeloid dendritic cell differentiation (GO:0043011)2.65794135
83sister chromatid segregation (GO:0000819)2.65554527
84negative regulation of interleukin-2 production (GO:0032703)2.65022171
85regulation of superoxide anion generation (GO:0032928)2.63127940
86cellular response to arsenic-containing substance (GO:0071243)2.61471351
87regulation of interleukin-17 production (GO:0032660)2.61041276
88ribonucleoprotein complex biogenesis (GO:0022613)2.60272716
89DNA strand elongation involved in DNA replication (GO:0006271)2.59957438
90macrophage activation involved in immune response (GO:0002281)2.58857909
91regulation of prostaglandin secretion (GO:0032306)2.57774552
92transcription from mitochondrial promoter (GO:0006390)2.56885722
93regulation of monocyte differentiation (GO:0045655)2.56743177
94ribosome assembly (GO:0042255)2.56734471
95regulation of mitotic spindle organization (GO:0060236)2.56500053
96regulation of myeloid leukocyte mediated immunity (GO:0002886)2.56266887
97positive regulation of gamma-delta T cell activation (GO:0046645)2.55931657
98amino sugar catabolic process (GO:0046348)2.55882153
99regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.55664662
100intracellular pH reduction (GO:0051452)2.55402538
101regulation of chronic inflammatory response (GO:0002676)2.54904071
102pore complex assembly (GO:0046931)2.53500119
103positive regulation of B cell differentiation (GO:0045579)2.52071640
104folic acid-containing compound metabolic process (GO:0006760)2.51691017
105granulocyte activation (GO:0036230)2.51275487
106positive regulation of chromosome segregation (GO:0051984)2.51234795
107negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.50909473
108protein localization to chromosome (GO:0034502)2.50121182
109positive regulation of protein homooligomerization (GO:0032464)2.49368694
110regulation of translation in response to stress (GO:0043555)2.49311191
111metaphase plate congression (GO:0051310)2.49092262
112NIK/NF-kappaB signaling (GO:0038061)2.49003963
113heterochromatin organization (GO:0070828)2.48753757
114regulation of RNA export from nucleus (GO:0046831)2.48260013
115myeloid dendritic cell activation (GO:0001773)2.47885647
116modulation by symbiont of host cellular process (GO:0044068)2.47162612
117DNA strand elongation (GO:0022616)2.45887180
118spliceosomal tri-snRNP complex assembly (GO:0000244)2.45788668
119regulation of T-helper 1 cell differentiation (GO:0045625)2.43836114
120pteridine-containing compound biosynthetic process (GO:0042559)2.43684125
121regulation of vitamin D biosynthetic process (GO:0060556)2.43471659
122response to protozoan (GO:0001562)2.42457312
123pinocytosis (GO:0006907)2.41877431
124negative regulation of T cell mediated immunity (GO:0002710)2.41850464
125regulation of posttranscriptional gene silencing (GO:0060147)2.41049104
126regulation of gene silencing by miRNA (GO:0060964)2.41049104
127regulation of gene silencing by RNA (GO:0060966)2.41049104
128chaperone mediated protein folding requiring cofactor (GO:0051085)2.40540067
129negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.40532855
130cell migration involved in heart development (GO:0060973)2.40242169
131regulation of histone H3-K9 methylation (GO:0051570)2.39853371
132positive regulation of protein import into nucleus, translocation (GO:0033160)2.39797496
133mitotic G1 DNA damage checkpoint (GO:0031571)2.39504602
134glycosphingolipid catabolic process (GO:0046479)2.37781307
135nuclear envelope organization (GO:0006998)2.37166446
136B cell mediated immunity (GO:0019724)2.36756872
137rRNA modification (GO:0000154)2.36554451
138chromatin assembly or disassembly (GO:0006333)2.36174585
139G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.36115115
140regulation of chromatin binding (GO:0035561)2.35438184
141regulation of podosome assembly (GO:0071801)2.34946924
142negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.34815801
143pH reduction (GO:0045851)2.34773821
144negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.34736620
145IMP metabolic process (GO:0046040)2.34319237
146response to peptidoglycan (GO:0032494)2.34088022
147regulation of alpha-beta T cell proliferation (GO:0046640)2.33932790
148DNA duplex unwinding (GO:0032508)2.33834224
149regulation of gamma-delta T cell activation (GO:0046643)2.32831465
150DNA geometric change (GO:0032392)2.32777502
151positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.31673146
152defense response to protozoan (GO:0042832)2.31651373
153DNA damage response, signal transduction resulting in transcription (GO:0042772)2.31139782
154meiotic chromosome segregation (GO:0045132)2.30596004
155lymphocyte apoptotic process (GO:0070227)2.29472835
156tetrahydrofolate metabolic process (GO:0046653)2.29084074
157extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)2.29029831
158negative regulation of interleukin-1 beta production (GO:0032691)2.28679920
159regulation of cytokine secretion involved in immune response (GO:0002739)2.28481779
160hydrogen peroxide biosynthetic process (GO:0050665)2.27623629
161positive regulation of alpha-beta T cell proliferation (GO:0046641)2.27430837
162negative regulation of nitric oxide biosynthetic process (GO:0045019)2.27429786
163positive regulation of lymphocyte apoptotic process (GO:0070230)2.26718558
164telomere maintenance via semi-conservative replication (GO:0032201)2.26512761
165negative regulation of leukocyte mediated immunity (GO:0002704)2.26495954
166immunoglobulin mediated immune response (GO:0016064)2.26021307
167regulation of integrin activation (GO:0033623)2.25615104
168establishment of chromosome localization (GO:0051303)2.25419931
169regulation of natural killer cell activation (GO:0032814)2.24732770
170positive regulation of interferon-beta production (GO:0032728)2.24645018
171rRNA processing (GO:0006364)2.24635075
172DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.23453663
173response to UV-C (GO:0010225)2.23363922
174antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.20948411
175antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.20948411
176attachment of spindle microtubules to kinetochore (GO:0008608)2.19349494
177rRNA metabolic process (GO:0016072)2.18722098
178modulation by virus of host process (GO:0019054)2.18377317
179glycine metabolic process (GO:0006544)2.18132801
180negative regulation of gene expression, epigenetic (GO:0045814)2.17670899
181negative regulation of cell size (GO:0045792)2.16919900
182regulation of SMAD protein import into nucleus (GO:0060390)2.16821821

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.74138380
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.96839105
3MYC_18555785_ChIP-Seq_MESCs_Mouse2.91108695
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.83774924
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.80510957
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.68506680
7MYC_22102868_ChIP-Seq_BL_Human2.53346555
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.45142414
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41419974
10VDR_21846776_ChIP-Seq_THP-1_Human2.02380409
11MYC_19030024_ChIP-ChIP_MESCs_Mouse1.98566118
12MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97464074
13MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96205946
14NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92628090
15* XRN2_22483619_ChIP-Seq_HELA_Human1.89636068
16ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.87332023
17ZNF263_19887448_ChIP-Seq_K562_Human1.84441304
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83747981
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74879236
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72723526
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.71950512
22TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71163941
23STAT3_1855785_ChIP-Seq_MESCs_Mouse1.70802756
24BP1_19119308_ChIP-ChIP_Hs578T_Human1.69062069
25* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.67991290
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64848605
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61690247
28VDR_23849224_ChIP-Seq_CD4+_Human1.61356478
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.58037503
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.57451299
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.51672542
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51433820
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.50748107
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49936637
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49267772
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.48080991
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47471803
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47265138
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46959230
40LXR_22292898_ChIP-Seq_THP-1_Human1.45646559
41SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44698192
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44633722
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43724416
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43500600
45DCP1A_22483619_ChIP-Seq_HELA_Human1.43060226
46CIITA_25753668_ChIP-Seq_RAJI_Human1.42112549
47TCF7_22412390_ChIP-Seq_EML_Mouse1.40698279
48TFEB_21752829_ChIP-Seq_HELA_Human1.40174969
49* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38625257
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37451828
51* KDM5A_27292631_Chip-Seq_BREAST_Human1.37252153
52FOXP3_21729870_ChIP-Seq_TREG_Human1.37144112
53GABP_19822575_ChIP-Seq_HepG2_Human1.35715223
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35682009
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35031191
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34209383
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.32944663
58KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32457173
59UTX_26944678_Chip-Seq_JUKART_Human1.32061377
60* MAF_26560356_Chip-Seq_TH1_Human1.31786245
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.31496515
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30445825
63SPI1_23547873_ChIP-Seq_NB4_Human1.30002135
64HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27745932
65BCOR_27268052_Chip-Seq_Bcells_Human1.25586072
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25276810
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25217107
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24592822
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.24167700
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23524255
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23197308
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23097051
73MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22977071
74* YY1_21170310_ChIP-Seq_MESCs_Mouse1.22727277
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21914455
76* MYB_26560356_Chip-Seq_TH1_Human1.21425506
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21381323
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20820584
79AR_21909140_ChIP-Seq_LNCAP_Human1.20730762
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20084119
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20014954
82BCL6_27268052_Chip-Seq_Bcells_Human1.19675193
83P68_20966046_ChIP-Seq_HELA_Human1.19353183
84* TTF2_22483619_ChIP-Seq_HELA_Human1.19303064
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.18641134
86MAF_26560356_Chip-Seq_TH2_Human1.18251827
87KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17142951
88KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16745901
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.16514483
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16200538
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15932347
92PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15453395
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.15259662
94SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15082495
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15076203
96CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14062503
97LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13274035
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12803807
99TET1_21451524_ChIP-Seq_MESCs_Mouse1.12798915
100NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12604745
101* SRF_21415370_ChIP-Seq_HL-1_Mouse1.12490720
102CTCF_26484167_Chip-Seq_Bcells_Mouse1.12174678
103CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12166023
104RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11664536
105CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11396844
106GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10911998
107PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10358132
108GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10050976
109* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09037365
110E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08534539
111MYB_26560356_Chip-Seq_TH2_Human1.04835874
112CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04715052
113ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03887944
114THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01428891
115VDR_24763502_ChIP-Seq_THP-1_Human1.01260468
116NCOR1_26117541_ChIP-Seq_K562_Human1.01222471
117KDM2B_26808549_Chip-Seq_DND41_Human1.01101367
118STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01029863
119SCL_19346495_ChIP-Seq_HPC-7_Human0.99603941
120IRF8_27001747_Chip-Seq_BMDM_Mouse0.99349768
121TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98676825
122HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98488369
123* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97212629
124GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96801513
125NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.96400955
126CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96073282
127BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96071983
128PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94950307

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.71807333
2MP0005451_abnormal_body_composition3.29721431
3MP0003111_abnormal_nucleus_morphology3.15729918
4MP0003077_abnormal_cell_cycle2.73879217
5MP0010094_abnormal_chromosome_stability2.62603148
6MP0004957_abnormal_blastocyst_morpholog2.58169480
7MP0008260_abnormal_autophagy2.56904556
8MP0003705_abnormal_hypodermis_morpholog2.53526143
9MP0010352_gastrointestinal_tract_polyps2.52848488
10MP0003724_increased_susceptibility_to2.52194852
11MP0008057_abnormal_DNA_replication2.38705558
12MP0000465_gastrointestinal_hemorrhage2.36916147
13MP0003436_decreased_susceptibility_to2.34660980
14MP0009840_abnormal_foam_cell2.29246781
15MP0010307_abnormal_tumor_latency2.25637838
16MP0003303_peritoneal_inflammation2.22443554
17MP0000685_abnormal_immune_system2.06985695
18MP0001835_abnormal_antigen_presentation1.95188207
19MP0005076_abnormal_cell_differentiation1.94467042
20MP0002254_reproductive_system_inflammat1.87381463
21MP0009333_abnormal_splenocyte_physiolog1.84380390
22MP0006082_CNS_inflammation1.81752556
23MP0001800_abnormal_humoral_immune1.81671801
24MP0009278_abnormal_bone_marrow1.76710156
25MP0008007_abnormal_cellular_replicative1.76632586
26MP0000350_abnormal_cell_proliferation1.75549828
27MP0008058_abnormal_DNA_repair1.71707465
28MP0005397_hematopoietic_system_phenotyp1.69818040
29MP0001545_abnormal_hematopoietic_system1.69818040
30MP0002452_abnormal_antigen_presenting1.69201836
31MP0001730_embryonic_growth_arrest1.64906055
32MP0002398_abnormal_bone_marrow1.64810204
33MP0002138_abnormal_hepatobiliary_system1.59652903
34MP0009764_decreased_sensitivity_to1.54837762
35MP0002396_abnormal_hematopoietic_system1.53969704
36MP0003075_altered_response_to1.53635181
37MP0000490_abnormal_crypts_of1.53541312
38MP0004510_myositis1.52399770
39MP0000604_amyloidosis1.51602684
40MP0005000_abnormal_immune_tolerance1.50745642
41MP0002723_abnormal_immune_serum1.50674409
42MP0000689_abnormal_spleen_morphology1.50535165
43MP0003763_abnormal_thymus_physiology1.50334680
44MP0002722_abnormal_immune_system1.47403186
45MP0001819_abnormal_immune_cell1.45667311
46MP0002420_abnormal_adaptive_immunity1.45548724
47MP0000343_altered_response_to1.40394820
48MP0004947_skin_inflammation1.40374807
49MP0003566_abnormal_cell_adhesion1.39025766
50MP0000716_abnormal_immune_system1.38702788
51MP0003656_abnormal_erythrocyte_physiolo1.37123487
52MP0001790_abnormal_immune_system1.35612585
53MP0005387_immune_system_phenotype1.35612585
54MP0009785_altered_susceptibility_to1.35212234
55MP0002419_abnormal_innate_immunity1.33249834
56MP0002429_abnormal_blood_cell1.32879157
57MP0005025_abnormal_response_to1.32241220
58MP0005310_abnormal_salivary_gland1.31806158
59MP0002019_abnormal_tumor_incidence1.31271536
60MP0008932_abnormal_embryonic_tissue1.31001076
61MP0000703_abnormal_thymus_morphology1.30836145
62MP0005380_embryogenesis_phenotype1.29948786
63MP0001672_abnormal_embryogenesis/_devel1.29948786
64MP0004808_abnormal_hematopoietic_stem1.28206376
65MP0000313_abnormal_cell_death1.26590906
66MP0005464_abnormal_platelet_physiology1.26583215
67MP0003984_embryonic_growth_retardation1.22962956
68MP0002080_prenatal_lethality1.22730826
69MP0002405_respiratory_system_inflammati1.22008328
70MP0006292_abnormal_olfactory_placode1.21824177
71MP0002088_abnormal_embryonic_growth/wei1.21472260
72MP0005360_urolithiasis1.20526066
73MP0005058_abnormal_lysosome_morphology1.20281816
74MP0003646_muscle_fatigue1.18690422
75MP0002998_abnormal_bone_remodeling1.17748714
76MP0001697_abnormal_embryo_size1.16479416
77MP0002086_abnormal_extraembryonic_tissu1.16477622
78MP0010155_abnormal_intestine_physiology1.10896469
79MP0005023_abnormal_wound_healing1.10812555
80MP0003448_altered_tumor_morphology1.10130416
81MP0001851_eye_inflammation1.08429008
82MP0003806_abnormal_nucleotide_metabolis1.08214250
83MP0001845_abnormal_inflammatory_respons1.07262987
84MP0000858_altered_metastatic_potential1.06788646
85MP0001986_abnormal_taste_sensitivity1.05902354
86MP0003191_abnormal_cellular_cholesterol1.05849600
87MP0003172_abnormal_lysosome_physiology1.05021939
88MP0004185_abnormal_adipocyte_glucose1.04642385
89MP0003300_gastrointestinal_ulcer1.02318068
90MP0004197_abnormal_fetal_growth/weight/1.01652808
91MP0005621_abnormal_cell_physiology1.00746713
92MP0005671_abnormal_response_to1.00558859
93MP0002933_joint_inflammation1.00135229
94MP0006036_abnormal_mitochondrial_physio0.98516067
95MP0003828_pulmonary_edema0.98288065
96MP0003453_abnormal_keratinocyte_physiol0.98116120
97MP0003221_abnormal_cardiomyocyte_apopto0.97311980
98MP0003123_paternal_imprinting0.97277335
99MP0002085_abnormal_embryonic_tissue0.96953642
100MP0000609_abnormal_liver_physiology0.96417576
101MP0002084_abnormal_developmental_patter0.94527011
102MP0002332_abnormal_exercise_endurance0.93198503
103MP0008004_abnormal_stomach_pH0.93142187
104MP0003329_amyloid_beta_deposits0.92346579
105MP0008469_abnormal_protein_level0.91537908
106MP0001853_heart_inflammation0.90958348
107MP0002139_abnormal_hepatobiliary_system0.90725588
108MP0000598_abnormal_liver_morphology0.88556519
109MP0001293_anophthalmia0.88135419
110MP0002166_altered_tumor_susceptibility0.88131135
111MP0003091_abnormal_cell_migration0.87396345
112MP0001663_abnormal_digestive_system0.85446021
113MP0005666_abnormal_adipose_tissue0.84654073
114MP0000358_abnormal_cell_content/0.83495561
115MP0002148_abnormal_hypersensitivity_rea0.81961493
116MP0001873_stomach_inflammation0.81321782
117MP0001533_abnormal_skeleton_physiology0.81057214
118MP0005384_cellular_phenotype0.80771249
119MP0001727_abnormal_embryo_implantation0.80595995
120MP0003786_premature_aging0.79764516
121MP0004264_abnormal_extraembryonic_tissu0.79687582
122MP0003567_abnormal_fetal_cardiomyocyte0.79000239
123MP0001915_intracranial_hemorrhage0.78912546
124MP0008995_early_reproductive_senescence0.77196754
125MP0002877_abnormal_melanocyte_morpholog0.76750526
126MP0009763_increased_sensitivity_to0.76657701
127MP0005647_abnormal_sex_gland0.75734005
128MP0008874_decreased_physiological_sensi0.73864034
129MP0002653_abnormal_ependyma_morphology0.73390079
130MP0004233_abnormal_muscle_weight0.73055693
131MP0003186_abnormal_redox_activity0.70531142
132MP0005166_decreased_susceptibility_to0.69874982
133MP0005319_abnormal_enzyme/_coenzyme0.69802212
134MP0006054_spinal_hemorrhage0.69273002
135MP0006035_abnormal_mitochondrial_morpho0.68376073
136MP0002132_abnormal_respiratory_system0.67913938
137MP0002234_abnormal_pharynx_morphology0.67899334
138MP0005390_skeleton_phenotype0.66151933

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune hemolytic anemia (HP:0001890)4.54458233
2Abnormality of glycolipid metabolism (HP:0010969)4.49785784
3Abnormality of liposaccharide metabolism (HP:0010968)4.49785784
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.49785784
5Abnormal delayed hypersensitivity skin test (HP:0002963)4.42124503
6Recurrent abscess formation (HP:0002722)3.71886524
7Loss of speech (HP:0002371)3.68416289
8Recurrent bacterial skin infections (HP:0005406)3.66394193
9Granulocytopenia (HP:0001913)3.63918567
10Increased cerebral lipofuscin (HP:0011813)3.62056788
11Ragged-red muscle fibers (HP:0003200)3.48792118
12Hypochromic anemia (HP:0001931)3.47783363
13Eosinophilia (HP:0001880)3.47549701
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.46786300
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.46786300
16Ependymoma (HP:0002888)3.37128819
17Dysostosis multiplex (HP:0000943)3.25502967
18Eczematoid dermatitis (HP:0000976)3.21250360
19Pustule (HP:0200039)3.16749114
20Autoimmune thrombocytopenia (HP:0001973)3.10253456
21Increased neuronal autofluorescent lipopigment (HP:0002074)3.09327669
22Abnormality of T cell number (HP:0011839)2.99625146
23Urticaria (HP:0001025)2.86769681
24Abnormality of the columella (HP:0009929)2.80169150
25Multiple enchondromatosis (HP:0005701)2.75840666
26Petechiae (HP:0000967)2.72532044
27Agnosia (HP:0010524)2.71879639
28Progressive external ophthalmoplegia (HP:0000590)2.68985399
29Carpal bone hypoplasia (HP:0001498)2.68675276
30Optic neuritis (HP:0100653)2.67897880
31Retrobulbar optic neuritis (HP:0100654)2.67897880
32Stomatitis (HP:0010280)2.65637591
33Recurrent gram-negative bacterial infections (HP:0005420)2.64605201
34Hepatosplenomegaly (HP:0001433)2.64254759
35Vasculitis (HP:0002633)2.59308074
36Pseudobulbar signs (HP:0002200)2.57662937
37Myositis (HP:0100614)2.56609699
38Abnormality of mucopolysaccharide metabolism (HP:0011020)2.56404171
39Abnormality of polysaccharide metabolism (HP:0011012)2.56404171
40Abnormality of glycosaminoglycan metabolism (HP:0004371)2.56404171
41Elevated erythrocyte sedimentation rate (HP:0003565)2.55122141
42Obstructive lung disease (HP:0006536)2.51572517
43Chronic obstructive pulmonary disease (HP:0006510)2.51572517
44Abnormality of eosinophils (HP:0001879)2.50399667
45Poikiloderma (HP:0001029)2.49596977
46Conjunctival telangiectasia (HP:0000524)2.48493414
47Vacuolated lymphocytes (HP:0001922)2.47799314
48Myocardial infarction (HP:0001658)2.47180886
49Hematochezia (HP:0002573)2.40631269
50Breast hypoplasia (HP:0003187)2.39561280
51Thrombocytosis (HP:0001894)2.37244258
52Abnormality of macrophages (HP:0004311)2.37017373
53Neonatal hypoglycemia (HP:0001998)2.34332014
54Hypergammaglobulinemia (HP:0010702)2.34208489
55Systemic lupus erythematosus (HP:0002725)2.33892126
56Personality changes (HP:0000751)2.33553730
57Entropion (HP:0000621)2.33392018
58Recurrent fungal infections (HP:0002841)2.31943574
59Mucopolysacchariduria (HP:0008155)2.31464959
60Urinary glycosaminoglycan excretion (HP:0003541)2.31464959
61Meningitis (HP:0001287)2.31273211
62Birth length less than 3rd percentile (HP:0003561)2.30866724
63Upper motor neuron abnormality (HP:0002127)2.25313106
64Gingivitis (HP:0000230)2.22608407
65Recurrent viral infections (HP:0004429)2.21922299
66Prominent nose (HP:0000448)2.20250821
67Abnormality of the astrocytes (HP:0100707)2.18075482
68Astrocytoma (HP:0009592)2.18075482
69Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.17783814
70Thoracic kyphosis (HP:0002942)2.15229530
71Abnormality of the vasculature of the conjunctiva (HP:0008054)2.15040180
72Agammaglobulinemia (HP:0004432)2.14589063
73Ulnar bowing (HP:0003031)2.14393371
74Abnormal gallbladder physiology (HP:0012438)2.13969769
75Cholecystitis (HP:0001082)2.13969769
76Apathy (HP:0000741)2.13944654
77Facial hemangioma (HP:0000329)2.13687220
78Mediastinal lymphadenopathy (HP:0100721)2.12032273
79Patellar aplasia (HP:0006443)2.10536062
80Diminished motivation (HP:0000745)2.09424189
81Easy fatigability (HP:0003388)2.09410678
82Cellulitis (HP:0100658)2.08996439
83Recurrent skin infections (HP:0001581)2.08649702
84Selective tooth agenesis (HP:0001592)2.07045092
85Fatigue (HP:0012378)2.06908897
86Myelodysplasia (HP:0002863)2.06073833
87Abnormality of the fingertips (HP:0001211)2.05993722
88Global brain atrophy (HP:0002283)2.05433012
89Chromsome breakage (HP:0040012)2.05159438
90Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04164003
91Chromosomal breakage induced by crosslinking agents (HP:0003221)2.03709738
92Increased serum ferritin (HP:0003281)2.03121290
93Increased IgM level (HP:0003496)2.02787259
94Abnormality of pyrimidine metabolism (HP:0004353)2.00289554
95Nasal polyposis (HP:0100582)1.99691051
96Abnormality of cells of the lymphoid lineage (HP:0012140)1.99641583
97Purpura (HP:0000979)1.99379229
98Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98251084
99Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97593841
100Premature skin wrinkling (HP:0100678)1.94274831
101Hypertensive crisis (HP:0100735)1.92594442
102Aplasia/Hypoplasia of the patella (HP:0006498)1.91466827
103Neutropenia (HP:0001875)1.91304664
104Premature ovarian failure (HP:0008209)1.91301905
105Colitis (HP:0002583)1.90587888
106Reticulocytopenia (HP:0001896)1.90362722
107Abnormality of the lower motor neuron (HP:0002366)1.90335187
108Bone marrow hypocellularity (HP:0005528)1.90182547
109Encephalitis (HP:0002383)1.89881124
110Osteomyelitis (HP:0002754)1.88412708
111Abnormality of the intervertebral disk (HP:0005108)1.87316016
112Neoplasm of striated muscle (HP:0009728)1.86440703
113Neuronal loss in central nervous system (HP:0002529)1.85787300
114Basal cell carcinoma (HP:0002671)1.85032941
115Abnormality of T cell physiology (HP:0011840)1.83769102
116Disinhibition (HP:0000734)1.83327808
117Hypergonadotropic hypogonadism (HP:0000815)1.82152921
118Microretrognathia (HP:0000308)1.81963091
119Abnormality of reticulocytes (HP:0004312)1.81890094
120Keratoconjunctivitis sicca (HP:0001097)1.81842816
121Abnormality of the thoracic spine (HP:0100711)1.81802912
122Impulsivity (HP:0100710)1.81400291
123Mutism (HP:0002300)1.80747807
124Progressive muscle weakness (HP:0003323)1.78391673
125Hand muscle atrophy (HP:0009130)1.77204437
126Reticulocytosis (HP:0001923)1.77124240
127Cafe-au-lait spot (HP:0000957)1.75498610
128Proximal placement of thumb (HP:0009623)1.75215943
129Medulloblastoma (HP:0002885)1.74846443
130Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.74668624
131Gastrointestinal infarctions (HP:0005244)1.74445870
132Abnormality of homocysteine metabolism (HP:0010919)1.73980490
133Homocystinuria (HP:0002156)1.73980490
134Orchitis (HP:0100796)1.72748191
135Rough bone trabeculation (HP:0100670)1.72691315
136Enlarged epiphyses (HP:0010580)1.72666764
137Leukocytosis (HP:0001974)1.72585382
138Emphysema (HP:0002097)1.72408311
139Abnormality of iron homeostasis (HP:0011031)1.72238807
140Rhabdomyosarcoma (HP:0002859)1.72218095
141Keratoconjunctivitis (HP:0001096)1.71557204
142Abnormality of T cells (HP:0002843)1.71413002
143Polyneuropathy (HP:0001271)1.71019583
144Impaired platelet aggregation (HP:0003540)1.70678224
145Abnormal platelet function (HP:0011869)1.70678224
146Deviation of the thumb (HP:0009603)1.70073287
147Nausea (HP:0002018)1.70003548
148Impaired proprioception (HP:0010831)1.69517714
149Lymphoma (HP:0002665)1.67971709
150Vertebral fusion (HP:0002948)1.67706739
151Nuclear cataract (HP:0100018)1.67621407
152Sparse lateral eyebrow (HP:0005338)1.67096691
153Increased muscle lipid content (HP:0009058)1.66916050
154Microvesicular hepatic steatosis (HP:0001414)1.66817600
155Abnormality of DNA repair (HP:0003254)1.66750547
156Anomalous pulmonary venous return (HP:0010772)1.66010623
157Poor head control (HP:0002421)1.65440509
158Abnormality of transition element cation homeostasis (HP:0011030)1.64760219
159Abnormal neuron morphology (HP:0012757)1.64661882
160Abnormality of the motor neurons (HP:0002450)1.64661882
161Pallor (HP:0000980)1.64616964
162Polycythemia (HP:0001901)1.64529560
163Abnormality of the nasal mucosa (HP:0000433)1.63666127
164Anorexia (HP:0002039)1.62882988
165Overlapping toe (HP:0001845)1.62771941
166Abnormality of chromosome stability (HP:0003220)1.62719642

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.85350171
2INSRR3.19501955
3PRPF4B3.05231150
4NEK22.68654643
5TAOK22.39668009
6TRIB32.35844325
7BUB12.28865714
8MAP3K102.11610970
9MAP4K12.08680533
10EEF2K2.02952451
11DYRK32.02419459
12TESK21.96683342
13CDK191.90667151
14CDC71.89503740
15PIK3CA1.86670690
16PKN21.83387478
17STK101.80310366
18ERN11.72481624
19WEE11.71571879
20GRK71.68929515
21NME21.67467275
22SRPK11.65333735
23TBK11.63593603
24PIM11.57547738
25TYK21.56248180
26RPS6KA41.53905766
27FES1.52757708
28MAP2K31.52122417
29MATK1.50437784
30TAOK11.49452518
31EIF2AK11.44208572
32BMPR21.42537944
33IRAK31.41383248
34BRD41.39644123
35MOS1.38103449
36PLK41.33978827
37CDK41.33191340
38TGFBR21.31898049
39SCYL21.27852966
40TTK1.25873025
41ZAP701.25094959
42FGR1.22252555
43SIK31.20716586
44CDK71.20287089
45CAMK1D1.17829772
46MAP3K61.14808418
47TSSK61.13571919
48DYRK1B1.11244303
49IRAK21.06991033
50MAP2K21.06459477
51CAMKK21.06178463
52STK41.04558397
53GRK61.03880962
54AURKB1.03318349
55TLK11.02721538
56LATS21.02456361
57MAP3K81.02408079
58MARK31.02237848
59RPS6KB21.00989229
60MAPK121.00755606
61MAP3K111.00715951
62PAK41.00685480
63ALK1.00372194
64TXK1.00268401
65CHEK20.99945335
66PLK10.99226934
67IKBKB0.98053507
68RIPK40.96691186
69MELK0.95918068
70JAK30.94973155
71SMG10.94664863
72PIM20.90525389
73STK30.88789250
74CSK0.88611387
75ACVR1B0.87922378
76TESK10.87411748
77MAP2K60.85980436
78PRKD20.85638612
79MAP3K140.83710884
80MAP3K30.83492392
81CSF1R0.83377410
82IKBKE0.81986558
83MAPKAPK30.80183574
84LCK0.79716837
85MAP3K10.79335796
86RIPK10.77493565
87PBK0.76758016
88ATR0.76185105
89CDK60.76144952
90PDK20.73563919
91FLT30.73562347
92CLK10.73561822
93BLK0.73042959
94SIK10.73031329
95BRSK20.72787258
96EIF2AK30.72025821
97MTOR0.71315391
98EPHA20.70994914
99IRAK40.70953202
100RET0.70416109
101CHEK10.69060915
102BMX0.68891775
103LRRK20.67084665
104SYK0.65904229
105LYN0.65311559
106CHUK0.64808656
107MAP2K40.62866708
108NLK0.59583646
109KIT0.59345968
110BTK0.58235497
111ABL20.58065562
112PAK10.57512002
113JAK10.57126637
114ICK0.57096868
115MAP3K50.56088895
116AURKA0.55704471
117PTK60.55479775
118CDK20.55244370
119JAK20.55220279
120LATS10.54535007
121MARK20.52847065
122ARAF0.52711140
123TAOK30.52516549
124HCK0.51968007
125KSR20.51576299
126KDR0.50709067
127BRAF0.49109898
128RAF10.48902773
129TTN0.48411533
130MAPKAPK20.47801218
131CDK90.47784846
132MAPK110.47533448
133TNK20.45781599
134NEK10.44304432
135BCKDK0.43601837
136ATM0.41982499
137MUSK0.40626545
138EPHB10.39947402
139SIK20.35066131
140PRKD10.30385584
141VRK20.29984668
142AKT20.29743321
143MAPK70.27880733
144CDC42BPA0.27650212
145RPS6KC10.26429777
146RPS6KL10.26429777

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.83565853
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.73980270
3African trypanosomiasis_Homo sapiens_hsa051432.37638282
4Sulfur relay system_Homo sapiens_hsa041222.37108717
5One carbon pool by folate_Homo sapiens_hsa006702.29644426
6RNA polymerase_Homo sapiens_hsa030202.28455785
7Mismatch repair_Homo sapiens_hsa034302.24105511
8RNA transport_Homo sapiens_hsa030132.21162634
9Autoimmune thyroid disease_Homo sapiens_hsa053202.17658672
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.10208857
11Cell cycle_Homo sapiens_hsa041101.94505933
12Spliceosome_Homo sapiens_hsa030401.92081058
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87671065
14p53 signaling pathway_Homo sapiens_hsa041151.83094397
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.80444774
16Rheumatoid arthritis_Homo sapiens_hsa053231.79378405
17Folate biosynthesis_Homo sapiens_hsa007901.75087623
18Base excision repair_Homo sapiens_hsa034101.74294769
19Pyrimidine metabolism_Homo sapiens_hsa002401.68255178
20Type I diabetes mellitus_Homo sapiens_hsa049401.67874554
21Antigen processing and presentation_Homo sapiens_hsa046121.60236169
22Herpes simplex infection_Homo sapiens_hsa051681.55114426
23Homologous recombination_Homo sapiens_hsa034401.53084775
24Ribosome_Homo sapiens_hsa030101.52038606
25Pentose phosphate pathway_Homo sapiens_hsa000301.47584534
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.45046721
27Epstein-Barr virus infection_Homo sapiens_hsa051691.44694629
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44590635
29Leishmaniasis_Homo sapiens_hsa051401.42129856
30Proteasome_Homo sapiens_hsa030501.41750557
31Apoptosis_Homo sapiens_hsa042101.39713778
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39492364
33Systemic lupus erythematosus_Homo sapiens_hsa053221.33790355
34B cell receptor signaling pathway_Homo sapiens_hsa046621.31140787
35Selenocompound metabolism_Homo sapiens_hsa004501.28954835
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28502392
37Salmonella infection_Homo sapiens_hsa051321.27103656
38Fanconi anemia pathway_Homo sapiens_hsa034601.26806370
39Nucleotide excision repair_Homo sapiens_hsa034201.26802071
40Viral carcinogenesis_Homo sapiens_hsa052031.23235084
41Legionellosis_Homo sapiens_hsa051341.19063676
42Vitamin B6 metabolism_Homo sapiens_hsa007501.17604141
43Staphylococcus aureus infection_Homo sapiens_hsa051501.16090363
44Osteoclast differentiation_Homo sapiens_hsa043801.14655135
45Chronic myeloid leukemia_Homo sapiens_hsa052201.12623663
46mRNA surveillance pathway_Homo sapiens_hsa030151.12398435
47Fructose and mannose metabolism_Homo sapiens_hsa000511.12002724
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05647864
49RNA degradation_Homo sapiens_hsa030181.05033602
50Acute myeloid leukemia_Homo sapiens_hsa052211.05021037
51Measles_Homo sapiens_hsa051621.03995501
52Intestinal immune network for IgA production_Homo sapiens_hsa046721.03468303
53Shigellosis_Homo sapiens_hsa051311.02802963
54Biosynthesis of amino acids_Homo sapiens_hsa012301.01475045
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01388589
56Basal transcription factors_Homo sapiens_hsa030221.01107558
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00236394
58mTOR signaling pathway_Homo sapiens_hsa041500.98140893
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.96549042
60Primary immunodeficiency_Homo sapiens_hsa053400.95024294
61Hepatitis B_Homo sapiens_hsa051610.94740484
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94277621
63Influenza A_Homo sapiens_hsa051640.94246444
64Regulation of autophagy_Homo sapiens_hsa041400.91132722
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90869635
66Small cell lung cancer_Homo sapiens_hsa052220.89403523
67TNF signaling pathway_Homo sapiens_hsa046680.88296917
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86730575
69Tuberculosis_Homo sapiens_hsa051520.86357000
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.85727534
71MicroRNAs in cancer_Homo sapiens_hsa052060.83906903
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83832331
73Hepatitis C_Homo sapiens_hsa051600.82565099
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80806177
75Pancreatic cancer_Homo sapiens_hsa052120.79411502
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77140888
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75982164
78Toxoplasmosis_Homo sapiens_hsa051450.74705129
79Non-homologous end-joining_Homo sapiens_hsa034500.72598041
80Phagosome_Homo sapiens_hsa041450.71771569
81Malaria_Homo sapiens_hsa051440.70692964
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68860190
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68669141
84HTLV-I infection_Homo sapiens_hsa051660.68361570
85Chemokine signaling pathway_Homo sapiens_hsa040620.68070033
86Pertussis_Homo sapiens_hsa051330.65313034
87Prolactin signaling pathway_Homo sapiens_hsa049170.65268185
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64404415
89T cell receptor signaling pathway_Homo sapiens_hsa046600.63035112
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.62839652
91Colorectal cancer_Homo sapiens_hsa052100.62614642
92Allograft rejection_Homo sapiens_hsa053300.61815824
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60999959
94Caffeine metabolism_Homo sapiens_hsa002320.59560282
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.59496627
96Bladder cancer_Homo sapiens_hsa052190.58691817
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58125772
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.57892436
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57469753
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56755203
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56382498
102Lysine degradation_Homo sapiens_hsa003100.55077951
103Asthma_Homo sapiens_hsa053100.54050354
104Notch signaling pathway_Homo sapiens_hsa043300.52034025
105HIF-1 signaling pathway_Homo sapiens_hsa040660.51783343
106Prion diseases_Homo sapiens_hsa050200.51637520
107FoxO signaling pathway_Homo sapiens_hsa040680.51320952
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50669810
109Hematopoietic cell lineage_Homo sapiens_hsa046400.50144379
110Viral myocarditis_Homo sapiens_hsa054160.50002010
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.49803124
112Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49746550
113Non-small cell lung cancer_Homo sapiens_hsa052230.49286826
114Purine metabolism_Homo sapiens_hsa002300.49192480
115Graft-versus-host disease_Homo sapiens_hsa053320.49069010
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48545877
117Lysosome_Homo sapiens_hsa041420.48143388
118Galactose metabolism_Homo sapiens_hsa000520.47594399
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46900198
120Insulin resistance_Homo sapiens_hsa049310.46825958
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46476517
122Other glycan degradation_Homo sapiens_hsa005110.45600925
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.44993114
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44280939
125VEGF signaling pathway_Homo sapiens_hsa043700.44022186
126Prostate cancer_Homo sapiens_hsa052150.43866841
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.41795118
128Sphingolipid metabolism_Homo sapiens_hsa006000.38598371
129Collecting duct acid secretion_Homo sapiens_hsa049660.35916711
130Endocytosis_Homo sapiens_hsa041440.31787547

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