GPATCH8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains an RNA-processing domain, a zinc finger domain, a lysine-rich region and a serine-rich region. A mutation in the serine-rich region of the protein is thought to be associated with hyperuricemia (PMID: 21594610). Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cAMP-mediated signaling (GO:0043951)5.42329955
2ER overload response (GO:0006983)5.40663813
3microtubule nucleation (GO:0007020)5.37238791
4positive regulation of macrophage activation (GO:0043032)5.31627334
5regulation of translation in response to stress (GO:0043555)5.14749694
6embryonic retina morphogenesis in camera-type eye (GO:0060059)5.06845405
7regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.78701946
8atrial cardiac muscle cell action potential (GO:0086014)4.67864503
9phosphatidylinositol phosphorylation (GO:0046854)4.09702491
10positive regulation of chemokine secretion (GO:0090197)4.04409310
11genitalia morphogenesis (GO:0035112)3.97931796
12histone H3-K4 trimethylation (GO:0080182)3.88413264
13negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.83859773
14ionotropic glutamate receptor signaling pathway (GO:0035235)3.82785672
15regulation of short-term neuronal synaptic plasticity (GO:0048172)3.82394801
16regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.82198524
17regulation of interleukin-13 production (GO:0032656)3.76066613
18histone mRNA catabolic process (GO:0071044)3.74268755
19lipid phosphorylation (GO:0046834)3.62216226
20negative regulation of chromatin modification (GO:1903309)3.59631391
21regulation of RNA export from nucleus (GO:0046831)3.59401699
22negative regulation of histone methylation (GO:0031061)3.58528998
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.55393536
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.54881582
25axon ensheathment in central nervous system (GO:0032291)3.53582500
26central nervous system myelination (GO:0022010)3.53582500
27positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.53563402
28toxin transport (GO:1901998)3.51836049
29neuron cell-cell adhesion (GO:0007158)3.50571396
30forebrain neuron differentiation (GO:0021879)3.50530575
31radial glial cell differentiation (GO:0060019)3.50513772
32cerebellar Purkinje cell differentiation (GO:0021702)3.48833750
33regulation of immunoglobulin secretion (GO:0051023)3.48649251
34histone lysine demethylation (GO:0070076)3.47219357
35primitive streak formation (GO:0090009)3.46892523
36negative regulation of histone modification (GO:0031057)3.42110706
37regulation of chemokine secretion (GO:0090196)3.37831859
38cell wall macromolecule catabolic process (GO:0016998)3.36932681
39glutamate receptor signaling pathway (GO:0007215)3.36599814
40cellular response to cholesterol (GO:0071397)3.36470976
41synaptic transmission, glutamatergic (GO:0035249)3.34581305
42centriole replication (GO:0007099)3.33587969
43negative regulation of mRNA processing (GO:0050686)3.31169447
44dendritic spine morphogenesis (GO:0060997)3.30322543
45locomotory exploration behavior (GO:0035641)3.29835603
46postsynaptic membrane organization (GO:0001941)3.29798026
47nucleosome disassembly (GO:0006337)3.23895009
48protein-DNA complex disassembly (GO:0032986)3.23895009
49regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.23531130
50histone demethylation (GO:0016577)3.23466449
51cellular response to sterol (GO:0036315)3.23441638
52regulation of nuclear cell cycle DNA replication (GO:0033262)3.18328123
53cerebellar granule cell differentiation (GO:0021707)3.18248958
54regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.16694940
55neuron-neuron synaptic transmission (GO:0007270)3.14210015
56synaptic vesicle maturation (GO:0016188)3.13821695
57positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.12794555
58positive regulation of cell cycle G2/M phase transition (GO:1902751)3.12794555
59lysosome localization (GO:0032418)3.09808821
60regulation of DNA endoreduplication (GO:0032875)3.09542162
61transmission of nerve impulse (GO:0019226)3.09524769
62pyrimidine dimer repair (GO:0006290)3.09427774
63histone H3-K36 demethylation (GO:0070544)3.07864268
64vocalization behavior (GO:0071625)3.06931753
65negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04897854
66neuron recognition (GO:0008038)3.01515889
67heart valve formation (GO:0003188)3.01153071
68positive regulation of gene expression, epigenetic (GO:0045815)3.00941737
69neuronal action potential propagation (GO:0019227)3.00623011
70presynaptic membrane assembly (GO:0097105)2.99508339
71regulation of non-canonical Wnt signaling pathway (GO:2000050)2.99323728
72negative regulation of smooth muscle cell differentiation (GO:0051151)2.96071170
73protein demethylation (GO:0006482)2.95455791
74protein dealkylation (GO:0008214)2.95455791
75cerebral cortex radially oriented cell migration (GO:0021799)2.94962068
76neurotransmitter-gated ion channel clustering (GO:0072578)2.93741214
77neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.93646904
78axonal fasciculation (GO:0007413)2.92298177
79neuroblast proliferation (GO:0007405)2.91172504
80protein localization to synapse (GO:0035418)2.90020491
81single strand break repair (GO:0000012)2.89606724
82auditory behavior (GO:0031223)2.89483505
83synaptic vesicle exocytosis (GO:0016079)2.88966086
84macroautophagy (GO:0016236)2.88660649
85peptidyl-glutamic acid carboxylation (GO:0017187)2.86598446
86protein carboxylation (GO:0018214)2.86598446
87synaptic vesicle endocytosis (GO:0048488)2.85990758
88negative regulation of RNA splicing (GO:0033119)2.85432074
89regulation of meiosis I (GO:0060631)2.84678150
90presynaptic membrane organization (GO:0097090)2.83249840
91histone H3-K9 modification (GO:0061647)2.83106102
92protein K48-linked deubiquitination (GO:0071108)2.82780821
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.79851073
94regulation of glutamate receptor signaling pathway (GO:1900449)2.78949241
95mannose metabolic process (GO:0006013)2.77862470
96positive regulation of CREB transcription factor activity (GO:0032793)2.76994732
97positive regulation of interleukin-4 production (GO:0032753)2.76686704
98myelination (GO:0042552)2.76375528
99regulation of respiratory system process (GO:0044065)2.76220411
100regulation of histone H3-K27 methylation (GO:0061085)2.76074064
101regulation of interleukin-5 production (GO:0032674)2.75591081
102regulation of excitatory postsynaptic membrane potential (GO:0060079)2.73911033
103negative regulation of neurotransmitter transport (GO:0051589)2.73872951
104ensheathment of neurons (GO:0007272)2.73390118
105axon ensheathment (GO:0008366)2.73390118
106cell migration in hindbrain (GO:0021535)2.71873803
107negative regulation of mRNA metabolic process (GO:1903312)2.71227236
108membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.71014347
109adult walking behavior (GO:0007628)2.70945043
110peptidyl-lysine trimethylation (GO:0018023)2.70717958
111regulation of nucleobase-containing compound transport (GO:0032239)2.70592535
112gamma-aminobutyric acid signaling pathway (GO:0007214)2.70497272
113regulation of chromatin silencing (GO:0031935)2.69849354
114histone H3-K4 methylation (GO:0051568)2.69691156
115regulation of postsynaptic membrane potential (GO:0060078)2.69575359
116regulation of histone H3-K4 methylation (GO:0051569)2.69132292
117regulation of synaptic vesicle exocytosis (GO:2000300)2.68089351
118protein K63-linked deubiquitination (GO:0070536)2.68047803
119cell differentiation in hindbrain (GO:0021533)2.67040639
120membrane hyperpolarization (GO:0060081)2.66927324
121negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.66619952
122peptidyl-lysine methylation (GO:0018022)2.65322583
123L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.65216010
124neuronal ion channel clustering (GO:0045161)2.64519513
125regulation of neuronal synaptic plasticity (GO:0048168)2.64506252
126histone H3-K9 demethylation (GO:0033169)2.64189775
127positive regulation by host of viral transcription (GO:0043923)2.63944226
128positive regulation of type 2 immune response (GO:0002830)2.63813424
129glutamate secretion (GO:0014047)2.63553785
130positive regulation of DNA-dependent DNA replication (GO:2000105)2.63405635
131negative regulation of translation, ncRNA-mediated (GO:0040033)2.62334286
132regulation of translation, ncRNA-mediated (GO:0045974)2.62334286
133negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.62334286
134mechanosensory behavior (GO:0007638)2.61708636
135central nervous system projection neuron axonogenesis (GO:0021952)2.60721722
136histone H4-K16 acetylation (GO:0043984)2.60347680
137lateral sprouting from an epithelium (GO:0060601)2.58872804
138regulation of long-term neuronal synaptic plasticity (GO:0048169)2.58223234
139dendrite morphogenesis (GO:0048813)2.58037824
140regulation of respiratory gaseous exchange (GO:0043576)2.57223213
141ectodermal placode formation (GO:0060788)2.56866699
142regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.56523222
143long-term memory (GO:0007616)2.56263220
144regulation of dendritic spine morphogenesis (GO:0061001)2.54886699
145secretory granule organization (GO:0033363)2.54755457
146response to folic acid (GO:0051593)2.54590758
147negative regulation of neurotransmitter secretion (GO:0046929)2.54413821
148cell wall macromolecule metabolic process (GO:0044036)2.53746180
149amino-acid betaine metabolic process (GO:0006577)2.53615306
150layer formation in cerebral cortex (GO:0021819)2.53475366
151monoubiquitinated protein deubiquitination (GO:0035520)2.52594304
152peptidyl-tyrosine autophosphorylation (GO:0038083)2.52345630
153convergent extension (GO:0060026)2.52154598
154L-amino acid import (GO:0043092)2.51146836
155startle response (GO:0001964)2.51138723
156histone H3-K9 methylation (GO:0051567)2.50650322
157synaptic vesicle docking involved in exocytosis (GO:0016081)2.50000953
158mitotic sister chromatid cohesion (GO:0007064)2.48802037
159positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.48126047
160histone lysine methylation (GO:0034968)2.47673125
161regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.47355299
162apical protein localization (GO:0045176)2.46313721
163negative regulation of protein localization to cell surface (GO:2000009)2.43872776
164membrane depolarization (GO:0051899)2.40996248
165limb bud formation (GO:0060174)2.40737116
166response to auditory stimulus (GO:0010996)2.39650061
167exploration behavior (GO:0035640)2.39571873
168positive regulation of meiosis (GO:0045836)2.38183209
169negative regulation of cytosolic calcium ion concentration (GO:0051481)2.37937081
170regulation of synaptic transmission, glutamatergic (GO:0051966)2.36104592
171regulation of voltage-gated calcium channel activity (GO:1901385)2.34803980
172cellular potassium ion homeostasis (GO:0030007)2.34264163
173head development (GO:0060322)2.34207800
174asymmetric protein localization (GO:0008105)2.33888660
175negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.33644871
176positive regulation of membrane potential (GO:0045838)2.31685332
177membrane depolarization during action potential (GO:0086010)2.31553989
178striatum development (GO:0021756)2.31157127
179nonmotile primary cilium assembly (GO:0035058)2.30954689
180cytoplasmic mRNA processing body assembly (GO:0033962)2.30715809
181righting reflex (GO:0060013)2.29405235
182regulation of neurotransmitter secretion (GO:0046928)2.27572004
183negative regulation of axonogenesis (GO:0050771)2.27530473
184innervation (GO:0060384)2.27448594
185neurotransmitter secretion (GO:0007269)2.26784497
186synapse assembly (GO:0007416)2.25860828
187synapse organization (GO:0050808)2.25676176

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.51113567
2GBX2_23144817_ChIP-Seq_PC3_Human3.73010970
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81510691
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.74262482
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.44467991
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42660155
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36348068
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.29006861
9DROSHA_22980978_ChIP-Seq_HELA_Human2.24808103
10* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.24543245
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17011481
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17011481
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.15870138
14* DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.10996195
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09591056
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.07926355
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.05516120
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04624451
19TAF15_26573619_Chip-Seq_HEK293_Human2.00491957
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.95451255
21* RARB_27405468_Chip-Seq_BRAIN_Mouse1.95364365
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.95351048
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95021844
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.92212508
25RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.89378114
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.88253604
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85488328
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84985151
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.81441035
30FUS_26573619_Chip-Seq_HEK293_Human1.80983482
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77243009
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.75669007
33REST_21632747_ChIP-Seq_MESCs_Mouse1.72397373
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.71626695
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71274039
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.69954662
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.68492151
38AR_21572438_ChIP-Seq_LNCaP_Human1.68385633
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67917689
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67769881
41* SMAD4_21799915_ChIP-Seq_A2780_Human1.66063859
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61832027
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59264559
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.58318335
45* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.58187349
46P300_19829295_ChIP-Seq_ESCs_Human1.56843283
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.56134453
48* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55621413
49IGF1R_20145208_ChIP-Seq_DFB_Human1.54640284
50* SMAD3_21741376_ChIP-Seq_EPCs_Human1.53714168
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53296331
52* STAT3_23295773_ChIP-Seq_U87_Human1.51963257
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51306325
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.50306686
55* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50232871
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46720740
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.45790002
58RNF2_27304074_Chip-Seq_NSC_Mouse1.45274737
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44908502
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42434233
61MYC_22102868_ChIP-Seq_BL_Human1.40359273
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39650103
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39207715
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39207715
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37822622
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37071405
67* TCF4_23295773_ChIP-Seq_U87_Human1.36938352
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36417509
69* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35921594
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34934628
71TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34636972
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.32775752
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32487591
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30922540
75YAP1_20516196_ChIP-Seq_MESCs_Mouse1.28736524
76CIITA_25753668_ChIP-Seq_RAJI_Human1.28682486
77E2F7_22180533_ChIP-Seq_HELA_Human1.28440788
78EWS_26573619_Chip-Seq_HEK293_Human1.28396055
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.26713427
80GATA1_26923725_Chip-Seq_HPCs_Mouse1.26568742
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.26565595
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25988540
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25165199
84CTNNB1_20460455_ChIP-Seq_HCT116_Human1.24687081
85* RING1B_27294783_Chip-Seq_NPCs_Mouse1.24652310
86AR_19668381_ChIP-Seq_PC3_Human1.24021728
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22699099
88FOXA2_19822575_ChIP-Seq_HepG2_Human1.22478001
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21800942
90PKCTHETA_26484144_Chip-Seq_BREAST_Human1.21747326
91* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21435332
92REST_18959480_ChIP-ChIP_MESCs_Mouse1.21344304
93AHR_22903824_ChIP-Seq_MCF-7_Human1.20770883
94NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.19904530
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.19811361
96KDM2B_26808549_Chip-Seq_JURKAT_Human1.19061930
97EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18981998
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17326339
99ISL1_27105846_Chip-Seq_CPCs_Mouse1.15371587
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14877863
101TP53_16413492_ChIP-PET_HCT116_Human1.13890512
102SOX9_26525672_Chip-Seq_HEART_Mouse1.12355118
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.11936012
104* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10923835
105KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10872264
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10716173
107AR_25329375_ChIP-Seq_VCAP_Human1.09109194
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09020620
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08645425
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07942252
111RUNX2_22187159_ChIP-Seq_PCA_Human1.06795571
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.06665240
113CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06483987
114HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06392067
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06351171
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05425998
117E2F1_18555785_Chip-Seq_ESCs_Mouse1.05273354
118RING1B_27294783_Chip-Seq_ESCs_Mouse1.04986406
119NFE2_27457419_Chip-Seq_LIVER_Mouse1.04912534
120* ER_23166858_ChIP-Seq_MCF-7_Human1.04892197
121TCF7_22412390_ChIP-Seq_EML_Mouse1.04862974
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04645752
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04618694
124STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02815794
125* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01920000
126WDR5_24793694_ChIP-Seq_LNCAP_Human1.01879935
127SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01503003
128STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00108197
129TP63_19390658_ChIP-ChIP_HaCaT_Human0.99843751
130TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.99754630
131OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98861361
132NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98523174
133DPY_21335234_ChIP-Seq_ESCs_Mouse0.97867727
134CMYC_18555785_Chip-Seq_ESCs_Mouse0.96872661
135STAT3_18555785_ChIP-Seq_MESCs_Mouse0.94668808
136* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93975165
137SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.93319612
138POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.91027721
139FLI1_21867929_ChIP-Seq_TH2_Mouse0.90350837
140* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88660775
141SMAD4_21741376_ChIP-Seq_HESCs_Human0.88355753
142TBX3_20139965_ChIP-Seq_ESCs_Mouse0.87867639
143TBX3_20139965_ChIP-Seq_MESCs_Mouse0.87604752
144WT1_19549856_ChIP-ChIP_CCG9911_Human0.87585796
145P53_22387025_ChIP-Seq_ESCs_Mouse0.86781037
146POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86718628

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.11613345
2MP0003880_abnormal_central_pattern3.32515773
3MP0000015_abnormal_ear_pigmentation2.97455385
4MP0004270_analgesia2.72005350
5MP0003635_abnormal_synaptic_transmissio2.71384328
6MP0002254_reproductive_system_inflammat2.50155044
7MP0001486_abnormal_startle_reflex2.37496471
8MP0003787_abnormal_imprinting2.35703093
9MP0008057_abnormal_DNA_replication2.29357196
10MP0009046_muscle_twitch2.25512952
11MP0005409_darkened_coat_color2.21869513
12MP0009745_abnormal_behavioral_response2.21690631
13MP0002064_seizures2.21480792
14MP0002272_abnormal_nervous_system2.17541297
15MP0002063_abnormal_learning/memory/cond2.15105587
16MP0005423_abnormal_somatic_nervous2.12906627
17MP0000778_abnormal_nervous_system2.12012475
18MP0002009_preneoplasia2.11722554
19MP0008877_abnormal_DNA_methylation2.10541615
20MP0002572_abnormal_emotion/affect_behav2.10473051
21MP0006292_abnormal_olfactory_placode2.02368454
22MP0000569_abnormal_digit_pigmentation2.01399656
23MP0004885_abnormal_endolymph1.92681078
24MP0005551_abnormal_eye_electrophysiolog1.90757867
25MP0002822_catalepsy1.85315850
26MP0002095_abnormal_skin_pigmentation1.80504287
27MP0008961_abnormal_basal_metabolism1.78241065
28MP0009703_decreased_birth_body1.77723544
29MP0001529_abnormal_vocalization1.74252757
30MP0002734_abnormal_mechanical_nocicepti1.73607706
31MP0005499_abnormal_olfactory_system1.72012571
32MP0005394_taste/olfaction_phenotype1.72012571
33MP0001968_abnormal_touch/_nociception1.68032107
34MP0000920_abnormal_myelination1.67645167
35MP0002067_abnormal_sensory_capabilities1.64561166
36MP0000566_synostosis1.64042110
37MP0002735_abnormal_chemical_nociception1.61462762
38MP0003283_abnormal_digestive_organ1.61301677
39MP0008995_early_reproductive_senescence1.58529236
40MP0002184_abnormal_innervation1.58075608
41MP0003121_genomic_imprinting1.56346007
42MP0003122_maternal_imprinting1.56251238
43MP0008569_lethality_at_weaning1.54649811
44MP0006072_abnormal_retinal_apoptosis1.54450201
45MP0002882_abnormal_neuron_morphology1.48646220
46MP0001188_hyperpigmentation1.44348087
47MP0001440_abnormal_grooming_behavior1.44289217
48MP0008789_abnormal_olfactory_epithelium1.43944716
49MP0002557_abnormal_social/conspecific_i1.43441260
50MP0004742_abnormal_vestibular_system1.43314733
51MP0000955_abnormal_spinal_cord1.42913854
52MP0001984_abnormal_olfaction1.41353970
53MP0001501_abnormal_sleep_pattern1.35548848
54MP0005386_behavior/neurological_phenoty1.33784891
55MP0004924_abnormal_behavior1.33784891
56MP0003890_abnormal_embryonic-extraembry1.29099158
57MP0005253_abnormal_eye_physiology1.26913485
58MP0002736_abnormal_nociception_after1.24651409
59MP0002638_abnormal_pupillary_reflex1.24544349
60MP0000631_abnormal_neuroendocrine_gland1.23616158
61MP0005187_abnormal_penis_morphology1.22028499
62MP0002152_abnormal_brain_morphology1.21434219
63MP0008058_abnormal_DNA_repair1.20103047
64MP0001970_abnormal_pain_threshold1.19726842
65MP0001299_abnormal_eye_distance/1.18032868
66MP0001905_abnormal_dopamine_level1.17885815
67MP0010030_abnormal_orbit_morphology1.17057869
68MP0004811_abnormal_neuron_physiology1.17036538
69MP0003950_abnormal_plasma_membrane1.15431029
70MP0005646_abnormal_pituitary_gland1.15000277
71MP0003861_abnormal_nervous_system1.14788221
72MP0004145_abnormal_muscle_electrophysio1.14725983
73MP0002752_abnormal_somatic_nervous1.14135721
74MP0003567_abnormal_fetal_cardiomyocyte1.12122427
75MP0001485_abnormal_pinna_reflex1.11405435
76MP0002733_abnormal_thermal_nociception1.11211295
77MP0002938_white_spotting1.11197364
78MP0002066_abnormal_motor_capabilities/c1.07522698
79MP0001293_anophthalmia1.07232109
80MP0005452_abnormal_adipose_tissue1.02667438
81MP0005076_abnormal_cell_differentiation1.02548385
82MP0002653_abnormal_ependyma_morphology1.02050351
83MP0003938_abnormal_ear_development1.01600477
84MP0002109_abnormal_limb_morphology1.01387749
85MP0001986_abnormal_taste_sensitivity0.99675557
86MP0002229_neurodegeneration0.99302302
87MP0003385_abnormal_body_wall0.99137146
88MP0005171_absent_coat_pigmentation0.98770650
89MP0003123_paternal_imprinting0.98281842
90MP0003632_abnormal_nervous_system0.98195700
91MP0003937_abnormal_limbs/digits/tail_de0.98146126
92MP0003077_abnormal_cell_cycle0.97248953
93MP0002970_abnormal_white_adipose0.97054713
94MP0003634_abnormal_glial_cell0.96639750
95MP0005645_abnormal_hypothalamus_physiol0.96378612
96MP0002114_abnormal_axial_skeleton0.95490532
97MP0009780_abnormal_chondrocyte_physiolo0.95389570
98MP0006035_abnormal_mitochondrial_morpho0.94939084
99MP0004197_abnormal_fetal_growth/weight/0.92092747
100MP0005367_renal/urinary_system_phenotyp0.92063111
101MP0000516_abnormal_urinary_system0.92063111
102MP0004142_abnormal_muscle_tone0.91913695
103MP0002106_abnormal_muscle_physiology0.91374781
104MP0005174_abnormal_tail_pigmentation0.90772836
105MP0005195_abnormal_posterior_eye0.90713701
106MP0010094_abnormal_chromosome_stability0.90503021
107MP0003755_abnormal_palate_morphology0.90441274
108MP0001270_distended_abdomen0.90406175
109MP0001502_abnormal_circadian_rhythm0.90194058
110MP0001943_abnormal_respiration0.90056766
111MP0005075_abnormal_melanosome_morpholog0.88950354
112MP0006276_abnormal_autonomic_nervous0.88591593
113MP0010770_preweaning_lethality0.88136960
114MP0002082_postnatal_lethality0.88136960
115MP0005369_muscle_phenotype0.85576863
116MP0001963_abnormal_hearing_physiology0.84028823
117MP0002115_abnormal_skeleton_extremities0.83985154
118MP0010769_abnormal_survival0.83219192
119MP0003935_abnormal_craniofacial_develop0.83045085
120MP0010768_mortality/aging0.82700734
121MP0002084_abnormal_developmental_patter0.81944841
122MP0002396_abnormal_hematopoietic_system0.81821098
123MP0004085_abnormal_heartbeat0.80847102
124MP0001286_abnormal_eye_development0.78408330
125MP0003136_yellow_coat_color0.78337401
126MP0003631_nervous_system_phenotype0.77693990
127MP0003984_embryonic_growth_retardation0.75902626
128MP0002751_abnormal_autonomic_nervous0.75387271
129MP0009115_abnormal_fat_cell0.75135196
130MP0000049_abnormal_middle_ear0.75033496
131MP0002088_abnormal_embryonic_growth/wei0.74533377
132MP0000432_abnormal_head_morphology0.74290710
133MP0002697_abnormal_eye_size0.74274927
134MP0000026_abnormal_inner_ear0.73425917
135MP0005391_vision/eye_phenotype0.72987644
136MP0003115_abnormal_respiratory_system0.72499726
137MP0000751_myopathy0.72134169
138MP0000428_abnormal_craniofacial_morphol0.71559121
139MP0002971_abnormal_brown_adipose0.71554271
140MP0003137_abnormal_impulse_conducting0.70175558
141MP0000647_abnormal_sebaceous_gland0.70173801
142MP0002081_perinatal_lethality0.68962426
143MP0002116_abnormal_craniofacial_bone0.68649222
144MP0001177_atelectasis0.68269767
145MP0002177_abnormal_outer_ear0.68027167
146MP0005248_abnormal_Harderian_gland0.67425836
147MP0004134_abnormal_chest_morphology0.66615434
148MP0004233_abnormal_muscle_weight0.66300677

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the right ventricle (HP:0001707)4.25053999
2Hip dysplasia (HP:0001385)4.00098680
3Conjugated hyperbilirubinemia (HP:0002908)3.79999554
4Rectal prolapse (HP:0002035)3.75798350
511 pairs of ribs (HP:0000878)3.73706870
6Long clavicles (HP:0000890)3.54240944
7Hypoplastic ischia (HP:0003175)3.41411658
8Focal motor seizures (HP:0011153)3.40885294
9Papilledema (HP:0001085)3.03560027
10Abnormality of the ischium (HP:0003174)2.95694610
11Abnormality of the renal cortex (HP:0011035)2.92442371
12Epileptic encephalopathy (HP:0200134)2.88230454
13Volvulus (HP:0002580)2.87302774
14Morphological abnormality of the inner ear (HP:0011390)2.85651199
15Febrile seizures (HP:0002373)2.83575058
16Focal seizures (HP:0007359)2.79915759
17Vitreoretinal degeneration (HP:0000655)2.78367826
18Progressive cerebellar ataxia (HP:0002073)2.77067360
19Abnormality of the aortic arch (HP:0012303)2.74621966
20Cerebral hypomyelination (HP:0006808)2.73179997
21Aqueductal stenosis (HP:0002410)2.69355968
22Degeneration of the lateral corticospinal tracts (HP:0002314)2.64034224
23Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.64034224
24Gaze-evoked nystagmus (HP:0000640)2.62278864
25Hypoplastic iliac wings (HP:0002866)2.61930132
26Atonic seizures (HP:0010819)2.61603062
27Broad palm (HP:0001169)2.59916629
28Thickened calvaria (HP:0002684)2.58006385
29Broad-based gait (HP:0002136)2.55605814
30Trigonocephaly (HP:0000243)2.54496083
31Abnormality of the 4th metacarpal (HP:0010012)2.53248313
32Alacrima (HP:0000522)2.51339071
33Genetic anticipation (HP:0003743)2.50988766
34Thin ribs (HP:0000883)2.50380380
35Tubulointerstitial fibrosis (HP:0005576)2.45327900
36High anterior hairline (HP:0009890)2.44681188
37Short chin (HP:0000331)2.43995487
38Abnormality of the labia minora (HP:0012880)2.39835783
39Decreased lacrimation (HP:0000633)2.38558734
40Increased nuchal translucency (HP:0010880)2.38449770
41Poikiloderma (HP:0001029)2.38014542
42Midline defect of the nose (HP:0004122)2.37753382
43Overlapping toe (HP:0001845)2.36987794
44Nephrogenic diabetes insipidus (HP:0009806)2.36897698
45Shawl scrotum (HP:0000049)2.35101149
46Metabolic alkalosis (HP:0200114)2.33209247
47Abnormality of the corticospinal tract (HP:0002492)2.33035891
48Thick eyebrow (HP:0000574)2.30100099
49Large hands (HP:0001176)2.29537964
50Myokymia (HP:0002411)2.28860145
51Entropion (HP:0000621)2.27357572
52Progressive sensorineural hearing impairment (HP:0000408)2.27177076
53Missing ribs (HP:0000921)2.24231005
54Urinary bladder sphincter dysfunction (HP:0002839)2.23354507
55Abnormality of the wing of the ilium (HP:0011867)2.22898248
56Action tremor (HP:0002345)2.22114238
57Supernumerary bones of the axial skeleton (HP:0009144)2.20298026
58Abnormality of the renal medulla (HP:0100957)2.18639006
59Abnormality of the nasal septum (HP:0000419)2.17537809
60Hypoplastic ilia (HP:0000946)2.14055086
61Widely spaced teeth (HP:0000687)2.13739055
62Truncal obesity (HP:0001956)2.13052704
63Basal cell carcinoma (HP:0002671)2.11798133
64Abnormality of chromosome segregation (HP:0002916)2.11640451
65Anophthalmia (HP:0000528)2.10484204
66Dysmetria (HP:0001310)2.09223589
67Blepharitis (HP:0000498)2.07775651
68Obstructive sleep apnea (HP:0002870)2.06966743
69Wide anterior fontanel (HP:0000260)2.04767856
70Fibular hypoplasia (HP:0003038)2.04618689
71Short 4th metacarpal (HP:0010044)2.04456723
72Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.04456723
73Cutaneous finger syndactyly (HP:0010554)2.04367346
74Urethral obstruction (HP:0000796)2.03571350
75Excessive salivation (HP:0003781)2.02454127
76Drooling (HP:0002307)2.02454127
77Highly arched eyebrow (HP:0002553)2.00389593
78Oligodactyly (hands) (HP:0001180)1.99868495
79Tented upper lip vermilion (HP:0010804)1.97638032
80Congenital stationary night blindness (HP:0007642)1.97003883
81Obsessive-compulsive behavior (HP:0000722)1.96603442
82Gastroesophageal reflux (HP:0002020)1.92938147
83Cutaneous melanoma (HP:0012056)1.92294752
84Abnormality of the parietal bone (HP:0002696)1.91974385
85Dysdiadochokinesis (HP:0002075)1.91883466
86Hypokalemic alkalosis (HP:0001949)1.91456416
87Oligodactyly (HP:0012165)1.89122389
88Abnormal hair whorl (HP:0010721)1.89009527
89Renal hypoplasia (HP:0000089)1.88509702
90Peripheral hypomyelination (HP:0007182)1.87519789
91Cupped ear (HP:0000378)1.87308404
92Absent frontal sinuses (HP:0002688)1.86689550
93Tubulointerstitial abnormality (HP:0001969)1.86590828
94Cutis marmorata (HP:0000965)1.86459721
95Spastic gait (HP:0002064)1.86280352
96Abnormality of chloride homeostasis (HP:0011422)1.86022688
97Irregular epiphyses (HP:0010582)1.86018134
98Broad face (HP:0000283)1.85722286
99Genital tract atresia (HP:0001827)1.85472067
100Small hand (HP:0200055)1.85358735
101Abnormality of incisor morphology (HP:0011063)1.85152709
102Tapered finger (HP:0001182)1.85047978
103Abnormality of the left ventricular outflow tract (HP:0011103)1.85027279
104Subaortic stenosis (HP:0001682)1.85027279
105Hypoplastic labia majora (HP:0000059)1.84620811
106Vaginal atresia (HP:0000148)1.84054744
107Hypoplastic nipples (HP:0002557)1.83477283
108Truncal ataxia (HP:0002078)1.83055376
109Absent speech (HP:0001344)1.82170635
110Termporal pattern (HP:0011008)1.81573183
111Insidious onset (HP:0003587)1.81573183
112Vertebral arch anomaly (HP:0008438)1.81484379
113Lissencephaly (HP:0001339)1.80247453
114Broad alveolar ridges (HP:0000187)1.78822970
115Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.78772105
116Absence seizures (HP:0002121)1.77483988
117Mitral regurgitation (HP:0001653)1.77173595
118Proximal placement of thumb (HP:0009623)1.75882596
119Premature ovarian failure (HP:0008209)1.75773134
120Protruding tongue (HP:0010808)1.75541165
121Cutaneous syndactyly (HP:0012725)1.75491611
122Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.75418241
123Vertebral hypoplasia (HP:0008417)1.75418241
124Macroorchidism (HP:0000053)1.73277531
125Arthropathy (HP:0003040)1.72154079
126Bowel incontinence (HP:0002607)1.71951454
127Abnormality of the fingertips (HP:0001211)1.71107984
128Labial hypoplasia (HP:0000066)1.71076273
129Round face (HP:0000311)1.70625510
130Sensory axonal neuropathy (HP:0003390)1.70346082
131Abnormality of the calcaneus (HP:0008364)1.70187762
132Morphological abnormality of the middle ear (HP:0008609)1.69993884
133Long eyelashes (HP:0000527)1.69466112
134Ankle clonus (HP:0011448)1.69094767
135Anteriorly placed anus (HP:0001545)1.68594851
136Narrow palate (HP:0000189)1.68010469
137Abnormality of the labia majora (HP:0012881)1.67852630
138Dialeptic seizures (HP:0011146)1.66122047
139Bell-shaped thorax (HP:0001591)1.65601346
140Abnormally folded helix (HP:0008544)1.65325889
141Ectopic kidney (HP:0000086)1.64601445
142Abnormality of the incisor (HP:0000676)1.64482908
143Aplasia/Hypoplasia of the sternum (HP:0006714)1.64420635
144Scanning speech (HP:0002168)1.63995106
145Supernumerary ribs (HP:0005815)1.63604501
146Anal stenosis (HP:0002025)1.62884826
147Overfolded helix (HP:0000396)1.62445140
148Hepatoblastoma (HP:0002884)1.61059179
149Hyperventilation (HP:0002883)1.60089539
150Impaired smooth pursuit (HP:0007772)1.59777872
151Vesicoureteral reflux (HP:0000076)1.59727477
152Hemiparesis (HP:0001269)1.59405917
153Supranuclear gaze palsy (HP:0000605)1.59326809
154Chin dimple (HP:0010751)1.57903409
155Gait imbalance (HP:0002141)1.57161841
156Neoplasm of the heart (HP:0100544)1.55680637
157Abnormal large intestine physiology (HP:0012700)1.55062218
158Papillary thyroid carcinoma (HP:0002895)1.54613730
159Thickened helices (HP:0000391)1.54423432
160Megalencephaly (HP:0001355)1.54422869
161Dysmetric saccades (HP:0000641)1.54111592
162Absent eyebrow (HP:0002223)1.53990217
163Bony spicule pigmentary retinopathy (HP:0007737)1.53584607
164Generalized tonic-clonic seizures (HP:0002069)1.53529668
165Abnormality of the columella (HP:0009929)1.53428092
166Septo-optic dysplasia (HP:0100842)1.52834711
167Urinary urgency (HP:0000012)1.52589481
168Esophageal atresia (HP:0002032)1.52583267
169Abnormality of the nasolacrimal system (HP:0000614)1.52016290
170Hypoplastic female external genitalia (HP:0012815)1.51827384

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK3.21538554
2FGFR33.19143916
3NTRK32.93765000
4EPHA42.74946744
5CAMK1G2.55168490
6MAP3K42.34398153
7ICK2.29732905
8BRD42.23197291
9NLK2.14319827
10CDK122.13933771
11WNK12.10676664
12FGFR22.05519682
13MAPK121.95777374
14STK391.93826030
15TNIK1.92682080
16SIK21.74693366
17NEK61.68598653
18MAPK131.60911007
19MARK11.56885080
20DMPK1.56431681
21PRPF4B1.50385701
22OXSR11.46184716
23BCR1.46172895
24PAK61.41020001
25NTRK21.38691896
26MARK21.38035374
27SGK4941.36646323
28SGK2231.36646323
29CAMK1D1.35408045
30UHMK11.34649441
31SIK31.29320709
32SGK21.27731355
33SIK11.25761800
34PLK21.25203991
35NUAK11.24166077
36MARK31.22029043
37CSNK1A1L1.21840499
38TYRO31.21172363
39MAP2K71.18115274
40CASK1.16575181
41MAP3K101.16511150
42MAP2K61.08310689
43LATS11.07457753
44KSR11.05083807
45PRKD31.04848651
46MINK11.01772305
47SGK30.99624336
48CDK50.96550835
49STK40.96189798
50MTOR0.94135055
51SGK10.91222270
52CSNK1G20.90049192
53CDC42BPA0.89936638
54STK30.89562819
55PRKD20.87926953
56CDK30.87439989
57PRKCH0.87058527
58CSNK1G30.86396313
59RIPK40.86148246
60PKN10.83804592
61FES0.80652350
62FGR0.80582132
63AKT30.79771329
64MAP3K90.79473757
65MAP2K40.79404593
66STK110.77957168
67DYRK1A0.77118639
68TAOK10.76749056
69MAP3K130.75425973
70MELK0.75149808
71FGFR40.74887490
72MAPKAPK50.72791681
73CAMK40.71895985
74CSNK1G10.71809996
75CAMK10.71456415
76MAPK100.70300136
77IRAK20.70201290
78HIPK20.70033615
79ROCK20.69710948
80YES10.69057627
81CAMK2A0.68765192
82FRK0.68389227
83CHUK0.66265528
84DAPK20.65899935
85WNK30.65674070
86CSNK1D0.65589187
87GSK3B0.65465757
88PTK2B0.65114802
89CAMK2B0.64413203
90PAK30.63892825
91CLK10.63395990
92EEF2K0.63152563
93MKNK20.60615908
94MKNK10.60534452
95CDK190.60487486
96BMPR1B0.58344289
97ERBB20.58283548
98BMPR20.57877373
99RPS6KA30.57806511
100MAP3K70.56371571
101CDC70.56059943
102CDK20.55889923
103ATR0.55361586
104ATM0.54384813
105CAMKK10.54294800
106FGFR10.54237430
107DYRK1B0.54234548
108MAPK80.53968260
109CSNK1E0.53776855
110EIF2AK10.53246787
111CDK10.53008113
112MAPK90.52364862
113CDK90.51569376
114CAMK2D0.51313466
115PRKAA10.50844139
116CHEK10.50745719
117CDK60.50500773
118CDK180.50253499
119MAPK140.50088519
120MAPK10.48670648
121PRKCE0.48551435
122NTRK10.48290287
123MAPK70.47735885
124AKT10.47731300
125PRKCB0.47524929
126CSNK1A10.47439210
127CDK150.47291863
128MAP4K10.47215318
129PDGFRB0.46988021
130PIM10.46008851
131IKBKE0.45023472
132TXK0.43365824
133WEE10.40220758
134MAP2K20.39202376
135STK380.38933962
136PRKDC0.38715568
137OBSCN0.38361274
138MAPK30.37211683
139MAP2K30.36733532
140RPS6KA60.35918158
141CDK80.35035432
142RPS6KC10.34751224

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.56591600
2Nicotine addiction_Homo sapiens_hsa050333.03518743
3Phototransduction_Homo sapiens_hsa047442.37500083
4Glutamatergic synapse_Homo sapiens_hsa047242.30164027
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22235965
6Circadian entrainment_Homo sapiens_hsa047132.15940445
7Morphine addiction_Homo sapiens_hsa050322.10473496
8GABAergic synapse_Homo sapiens_hsa047272.08417392
9Long-term potentiation_Homo sapiens_hsa047202.03854042
10Axon guidance_Homo sapiens_hsa043601.84842332
11Amphetamine addiction_Homo sapiens_hsa050311.82258674
12Dopaminergic synapse_Homo sapiens_hsa047281.79752229
13Long-term depression_Homo sapiens_hsa047301.74558741
14Olfactory transduction_Homo sapiens_hsa047401.67206389
15Cocaine addiction_Homo sapiens_hsa050301.64407739
16Serotonergic synapse_Homo sapiens_hsa047261.60637140
17Cholinergic synapse_Homo sapiens_hsa047251.58798178
18Synaptic vesicle cycle_Homo sapiens_hsa047211.57600274
19FoxO signaling pathway_Homo sapiens_hsa040681.57237144
20Salivary secretion_Homo sapiens_hsa049701.54371799
21Taste transduction_Homo sapiens_hsa047421.47351472
22Dorso-ventral axis formation_Homo sapiens_hsa043201.40518009
23Oxytocin signaling pathway_Homo sapiens_hsa049211.39264574
24Insulin secretion_Homo sapiens_hsa049111.38103332
25Renin secretion_Homo sapiens_hsa049241.36656927
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31765358
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28408345
28Calcium signaling pathway_Homo sapiens_hsa040201.27391553
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25064569
30cAMP signaling pathway_Homo sapiens_hsa040241.24612281
31Gastric acid secretion_Homo sapiens_hsa049711.21833008
32Type II diabetes mellitus_Homo sapiens_hsa049301.21577940
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.19821805
34GnRH signaling pathway_Homo sapiens_hsa049121.18516006
35ErbB signaling pathway_Homo sapiens_hsa040121.17527989
36Chronic myeloid leukemia_Homo sapiens_hsa052201.16569263
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15232931
38Wnt signaling pathway_Homo sapiens_hsa043101.14122321
39Basal cell carcinoma_Homo sapiens_hsa052171.13473760
40Hedgehog signaling pathway_Homo sapiens_hsa043401.11024244
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08974120
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08207475
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08084204
44Gap junction_Homo sapiens_hsa045401.07981220
45Melanogenesis_Homo sapiens_hsa049161.06288461
46Fanconi anemia pathway_Homo sapiens_hsa034601.05673817
47Non-homologous end-joining_Homo sapiens_hsa034501.04809642
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03290827
49RNA transport_Homo sapiens_hsa030131.02106347
50MAPK signaling pathway_Homo sapiens_hsa040101.00709240
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00497008
52Renal cell carcinoma_Homo sapiens_hsa052110.99818301
53Dilated cardiomyopathy_Homo sapiens_hsa054140.98246175
54Cell cycle_Homo sapiens_hsa041100.96015097
55Spliceosome_Homo sapiens_hsa030400.93435613
56Oocyte meiosis_Homo sapiens_hsa041140.93392663
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.92299567
58Glioma_Homo sapiens_hsa052140.92169716
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91770106
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90894013
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.89946337
62Choline metabolism in cancer_Homo sapiens_hsa052310.89412754
63Acute myeloid leukemia_Homo sapiens_hsa052210.88849404
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87218998
65Estrogen signaling pathway_Homo sapiens_hsa049150.87212189
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84846049
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84516678
68mRNA surveillance pathway_Homo sapiens_hsa030150.83724491
69Inositol phosphate metabolism_Homo sapiens_hsa005620.83263523
70Glucagon signaling pathway_Homo sapiens_hsa049220.83126084
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79903652
72Homologous recombination_Homo sapiens_hsa034400.77655912
73Ras signaling pathway_Homo sapiens_hsa040140.76851394
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76425857
75Insulin resistance_Homo sapiens_hsa049310.76366950
76Base excision repair_Homo sapiens_hsa034100.75769793
77Prolactin signaling pathway_Homo sapiens_hsa049170.74050040
78Colorectal cancer_Homo sapiens_hsa052100.73694693
79Basal transcription factors_Homo sapiens_hsa030220.73346515
80T cell receptor signaling pathway_Homo sapiens_hsa046600.73208553
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72052972
82Hippo signaling pathway_Homo sapiens_hsa043900.71973192
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71825241
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.71447780
85Rap1 signaling pathway_Homo sapiens_hsa040150.70585164
86Endometrial cancer_Homo sapiens_hsa052130.70561702
87Circadian rhythm_Homo sapiens_hsa047100.69903125
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69495740
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69062859
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68892090
91B cell receptor signaling pathway_Homo sapiens_hsa046620.67909986
92Notch signaling pathway_Homo sapiens_hsa043300.67830326
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67477666
94Hepatitis B_Homo sapiens_hsa051610.66411854
95Selenocompound metabolism_Homo sapiens_hsa004500.66356960
96Tight junction_Homo sapiens_hsa045300.65581464
97Alcoholism_Homo sapiens_hsa050340.65488085
98Pancreatic secretion_Homo sapiens_hsa049720.65128444
99Lysine degradation_Homo sapiens_hsa003100.63769990
100Ovarian steroidogenesis_Homo sapiens_hsa049130.63445317
101MicroRNAs in cancer_Homo sapiens_hsa052060.63249275
102Platelet activation_Homo sapiens_hsa046110.62588958
103Insulin signaling pathway_Homo sapiens_hsa049100.62572089
104Ether lipid metabolism_Homo sapiens_hsa005650.62327281
105AMPK signaling pathway_Homo sapiens_hsa041520.61490309
106Adherens junction_Homo sapiens_hsa045200.61431920
107Prostate cancer_Homo sapiens_hsa052150.61368721
108Cardiac muscle contraction_Homo sapiens_hsa042600.60901777
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59261254
110Chemokine signaling pathway_Homo sapiens_hsa040620.59231062
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59108722
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58653370
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57486881
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57080200
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57065703
116HTLV-I infection_Homo sapiens_hsa051660.56067928
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.55978158
118mTOR signaling pathway_Homo sapiens_hsa041500.54697189
119Non-small cell lung cancer_Homo sapiens_hsa052230.54023829
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53086936
121Pathways in cancer_Homo sapiens_hsa052000.50447089
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50374099
123VEGF signaling pathway_Homo sapiens_hsa043700.50066199
124Endocytosis_Homo sapiens_hsa041440.47446680
125Collecting duct acid secretion_Homo sapiens_hsa049660.47114591
126Melanoma_Homo sapiens_hsa052180.46203769
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45308250
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44944074
129Proteoglycans in cancer_Homo sapiens_hsa052050.43013757

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