GPBAR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Notch signaling involved in heart development (GO:0061314)7.58367649
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.32714928
3negative regulation of cell killing (GO:0031342)6.32714928
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.16138673
5neutrophil activation involved in immune response (GO:0002283)5.97961735
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.97087857
7positive regulation by organism of defense response of other organism involved in symbiotic interact5.97087857
8modulation by symbiont of host immune response (GO:0052553)5.97087857
9positive regulation by symbiont of host defense response (GO:0052509)5.97087857
10modulation by symbiont of host defense response (GO:0052031)5.97087857
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.97087857
12positive regulation of gamma-delta T cell activation (GO:0046645)5.70922172
13antigen processing and presentation of endogenous antigen (GO:0019883)5.44351678
14glomerulus development (GO:0032835)5.35160582
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.33482675
16detection of other organism (GO:0098543)5.32325279
17neural crest cell development (GO:0014032)5.22087010
18detection of bacterium (GO:0016045)5.21056308
19response to peptidoglycan (GO:0032494)5.16854256
20nephron tubule development (GO:0072080)5.12518865
21macrophage activation involved in immune response (GO:0002281)5.11545254
22regulation of apoptotic process involved in morphogenesis (GO:1902337)4.84887947
23negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.83007687
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.77783929
25cardiac right ventricle morphogenesis (GO:0003215)4.67027590
26nephron epithelium development (GO:0072009)4.63477670
27leukocyte aggregation (GO:0070486)4.62074383
28cell surface receptor signaling pathway involved in heart development (GO:0061311)4.57956260
29mesenchymal cell development (GO:0014031)4.55929635
30negative regulation of interleukin-12 production (GO:0032695)4.54859416
31atrioventricular valve morphogenesis (GO:0003181)4.53367580
32negative regulation of metanephros development (GO:0072217)4.50558544
33leukocyte migration involved in inflammatory response (GO:0002523)4.46569435
34renal tubule development (GO:0061326)4.44501047
35auditory receptor cell differentiation (GO:0042491)4.42318933
36detection of external biotic stimulus (GO:0098581)4.41247261
37response to muramyl dipeptide (GO:0032495)4.35626925
38heart valve morphogenesis (GO:0003179)4.34021921
39regulation of B cell receptor signaling pathway (GO:0050855)4.33015586
40immunoglobulin mediated immune response (GO:0016064)4.30737609
41neutrophil activation (GO:0042119)4.24067652
42respiratory burst (GO:0045730)4.23480546
43nephron tubule formation (GO:0072079)4.23218490
44negative regulation of lymphocyte mediated immunity (GO:0002707)4.16054618
45regulation of mast cell degranulation (GO:0043304)4.14456791
46regulation of gamma-delta T cell activation (GO:0046643)4.14084843
47regulation of interferon-beta biosynthetic process (GO:0045357)4.09618216
48cranial suture morphogenesis (GO:0060363)4.07582171
49aorta morphogenesis (GO:0035909)4.05788203
50detection of molecule of bacterial origin (GO:0032490)4.05457987
51cellular extravasation (GO:0045123)4.04985735
52cell adhesion mediated by integrin (GO:0033627)4.04594338
53microglial cell activation (GO:0001774)4.01530854
54response to host immune response (GO:0052572)4.01153565
55response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.01153565
56positive regulation of mast cell activation (GO:0033005)3.98015874
57embryonic retina morphogenesis in camera-type eye (GO:0060059)3.96932587
58myeloid cell activation involved in immune response (GO:0002275)3.94665350
59negative regulation of chondrocyte differentiation (GO:0032331)3.93261380
60granulocyte activation (GO:0036230)3.91072951
61detection of biotic stimulus (GO:0009595)3.87001784
62regulation of myeloid leukocyte mediated immunity (GO:0002886)3.85353663
63regulation of T cell tolerance induction (GO:0002664)3.84792621
64neuronal stem cell maintenance (GO:0097150)3.84564471
65epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.83978747
66morphogenesis of an epithelial sheet (GO:0002011)3.82901767
67regulation of mast cell activation involved in immune response (GO:0033006)3.82877984
68positive regulation of SMAD protein import into nucleus (GO:0060391)3.78623726
69negative regulation of leukocyte mediated immunity (GO:0002704)3.77019799
70chondrocyte proliferation (GO:0035988)3.75024735
71positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.73617211
72macrophage activation (GO:0042116)3.72467437
73cell proliferation involved in metanephros development (GO:0072203)3.71832279
74regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.69501492
75regulation of leukocyte degranulation (GO:0043300)3.69055290
76regulation of SMAD protein import into nucleus (GO:0060390)3.67877918
77negative regulation of erythrocyte differentiation (GO:0045647)3.67628692
78cell proliferation involved in kidney development (GO:0072111)3.66779178
79response to host defenses (GO:0052200)3.66525608
80response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.66525608
81response to host (GO:0075136)3.66525608
82mesodermal cell differentiation (GO:0048333)3.65033844
83nephron tubule morphogenesis (GO:0072078)3.64552230
84nephron epithelium morphogenesis (GO:0072088)3.64552230
85regulation of tolerance induction (GO:0002643)3.63650707
86stem cell development (GO:0048864)3.61818510
87regulation of mast cell activation (GO:0033003)3.60353495
88regulation of tight junction assembly (GO:2000810)3.60303482
89negative regulation of T cell mediated immunity (GO:0002710)3.59763869
90endocardial cushion development (GO:0003197)3.59369649
91positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.57125755
92extracellular matrix assembly (GO:0085029)3.56575802
93regulation of mesenchymal cell apoptotic process (GO:2001053)3.54527663
94negative regulation of stem cell proliferation (GO:2000647)3.50445293
95response to interleukin-15 (GO:0070672)3.49502323
96antigen processing and presentation via MHC class Ib (GO:0002475)3.48964849
97negative regulation of phagocytosis (GO:0050765)3.48776378
98metanephric mesenchyme development (GO:0072075)3.47369954
99positive regulation of mast cell degranulation (GO:0043306)3.47368776
100positive regulation of mast cell activation involved in immune response (GO:0033008)3.47368776
101cardiac epithelial to mesenchymal transition (GO:0060317)3.46321830
102regulation of stem cell maintenance (GO:2000036)3.41662097
103cellular response to type I interferon (GO:0071357)3.41610967
104type I interferon signaling pathway (GO:0060337)3.41610967
105negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.40650324
106kidney mesenchyme development (GO:0072074)3.39549559
107response to type I interferon (GO:0034340)3.38948817
108regulation of gamma-delta T cell differentiation (GO:0045586)3.38514013
109inner ear receptor cell differentiation (GO:0060113)3.37857479
110lymphangiogenesis (GO:0001946)3.37329261
111response to laminar fluid shear stress (GO:0034616)3.34793197
112B cell mediated immunity (GO:0019724)3.34255736
113positive regulation of p38MAPK cascade (GO:1900745)3.32173980
114kidney epithelium development (GO:0072073)3.30739002
115positive regulation of cartilage development (GO:0061036)3.30667254
116cardiac septum morphogenesis (GO:0060411)3.30548828
117response to fluid shear stress (GO:0034405)3.28270078
118mesenchymal cell proliferation (GO:0010463)3.28165110
119neutrophil mediated immunity (GO:0002446)3.27108967
120regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.26588250
121regulation of hippo signaling (GO:0035330)3.26137513
122leukocyte degranulation (GO:0043299)3.25643680
123cell migration involved in heart development (GO:0060973)3.24621380
124regulation of T-helper 2 cell differentiation (GO:0045628)3.21796133
125production of molecular mediator involved in inflammatory response (GO:0002532)3.20968876
126regulation of regulated secretory pathway (GO:1903305)3.18734518
127respiratory tube development (GO:0030323)3.17837238
128regulation of mesonephros development (GO:0061217)3.13638358
129negative regulation of cytokine production involved in immune response (GO:0002719)3.13605800
130embryonic viscerocranium morphogenesis (GO:0048703)3.13604985
131interferon-gamma-mediated signaling pathway (GO:0060333)3.12872728
132positive regulation of tolerance induction (GO:0002645)3.12512376
133defense response to protozoan (GO:0042832)3.09765672
134positive regulation of endothelial cell apoptotic process (GO:2000353)3.09187347
135B cell receptor signaling pathway (GO:0050853)3.08744939
136basement membrane organization (GO:0071711)3.07642419
137regulation of gastrulation (GO:0010470)3.06789547
138positive regulation of epithelial to mesenchymal transition (GO:0010718)3.06729820
139cellular response to interleukin-15 (GO:0071350)3.05036938
140regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.04047987
141fibril organization (GO:0097435)3.03982663
142craniofacial suture morphogenesis (GO:0097094)3.03544908
143negative regulation of innate immune response (GO:0045824)3.02889671
144negative regulation of cartilage development (GO:0061037)3.02508243
145positive regulation of B cell differentiation (GO:0045579)3.02232996
146body morphogenesis (GO:0010171)3.01587993
147negative regulation of interleukin-6 production (GO:0032715)3.01575883
148actin filament depolymerization (GO:0030042)3.01480934
149regulation of dendritic cell antigen processing and presentation (GO:0002604)3.01453019
150cartilage morphogenesis (GO:0060536)3.00719528
151Golgi transport vesicle coating (GO:0048200)3.00307240
152COPI coating of Golgi vesicle (GO:0048205)3.00307240
153regulation of antigen processing and presentation (GO:0002577)3.00149011
154lipopolysaccharide-mediated signaling pathway (GO:0031663)3.00047596
155positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.99723427
156positive regulation of cellular amide metabolic process (GO:0034250)2.99659963
157outflow tract septum morphogenesis (GO:0003148)2.99488471
158negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.98930153
159regulation of B cell differentiation (GO:0045577)2.97892673
160mechanoreceptor differentiation (GO:0042490)2.95726377
161regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.95343077
162negative regulation of alpha-beta T cell activation (GO:0046636)2.93343238
163regulation of metanephros development (GO:0072215)2.93137827
164cardiac ventricle morphogenesis (GO:0003208)2.92830312
165corticosteroid receptor signaling pathway (GO:0031958)2.91888190
166regulation of T cell mediated cytotoxicity (GO:0001914)2.91703838
167positive regulation of antigen processing and presentation (GO:0002579)2.90799910
168collagen fibril organization (GO:0030199)2.90090654
169myeloid leukocyte activation (GO:0002274)2.89608107
170positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.89217889
171negative regulation of type 2 immune response (GO:0002829)2.88007781
172negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.87935975
173germinal center formation (GO:0002467)2.87573658
174endoderm formation (GO:0001706)2.87547800
175mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.87509833
176ureteric bud development (GO:0001657)2.87456189
177regulation of natural killer cell mediated immunity (GO:0002715)2.86794229
178regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.86794229
179mesonephric tubule development (GO:0072164)2.85877493
180myeloid leukocyte mediated immunity (GO:0002444)2.84353919
181sequestering of extracellular ligand from receptor (GO:0035581)2.84266383
182renal tubule morphogenesis (GO:0061333)2.82587695
183tolerance induction (GO:0002507)2.80741904
184positive regulation of T cell mediated cytotoxicity (GO:0001916)2.80688870
185endocardial cushion morphogenesis (GO:0003203)2.79934869
186regulation of cell fate specification (GO:0042659)2.79828490
187wound healing, spreading of cells (GO:0044319)2.79454499
188wound healing, spreading of epidermal cells (GO:0035313)2.77622567
189epithelial to mesenchymal transition (GO:0001837)2.77534167
190xenobiotic catabolic process (GO:0042178)2.76950145
191blood vessel remodeling (GO:0001974)2.76654314
192mesonephric epithelium development (GO:0072163)2.76504694
193lung morphogenesis (GO:0060425)2.75462534
194positive regulation of osteoblast differentiation (GO:0045669)2.71812116
195cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.71720802
196regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.70199123
197positive regulation of collagen biosynthetic process (GO:0032967)2.70035747
198Notch receptor processing (GO:0007220)2.69346651
199lateral sprouting from an epithelium (GO:0060601)2.68981801

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.77742419
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.54571804
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.36187685
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.21424430
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.08567875
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.89919618
7CLOCK_20551151_ChIP-Seq_293T_Human3.75458620
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.61730920
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.20289248
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.12925031
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.08533042
12VDR_21846776_ChIP-Seq_THP-1_Human3.06242937
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.80620869
14VDR_24763502_ChIP-Seq_THP-1_Human2.80473120
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.76701692
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71215448
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.71142726
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.68441827
19SPI1_23127762_ChIP-Seq_K562_Human2.64180649
20SPI1_23547873_ChIP-Seq_NB4_Human2.60368520
21RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.58694102
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.57629153
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.53604138
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.51913656
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41382248
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41091765
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.33959257
28MAF_26560356_Chip-Seq_TH1_Human2.33400898
29RUNX_20019798_ChIP-Seq_JUKART_Human2.29139183
30RUNX1_22412390_ChIP-Seq_EML_Mouse2.27912127
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.25578825
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22488115
33CJUN_26792858_Chip-Seq_BT549_Human2.19494795
34SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.18382515
35SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.18382515
36SCL_19346495_ChIP-Seq_HPC-7_Human2.14289387
37UTX_26944678_Chip-Seq_JUKART_Human2.11427904
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.10817630
39ESR1_21235772_ChIP-Seq_MCF-7_Human2.10187517
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.09960225
41KDM2B_26808549_Chip-Seq_SUP-B15_Human2.09682872
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.09246033
43HIF1A_21447827_ChIP-Seq_MCF-7_Human2.09181219
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.06167357
45AR_21909140_ChIP-Seq_LNCAP_Human2.05995149
46* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.05351290
47BRD4_27068464_Chip-Seq_AML-cells_Mouse2.03688729
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.03406442
49CDX2_20551321_ChIP-Seq_CACO-2_Human2.03153999
50MYC_22102868_ChIP-Seq_BL_Human2.02434799
51STAT4_19710469_ChIP-ChIP_TH1__Mouse2.01992426
52CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.00844051
53SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.98990504
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.94679464
55* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.92788537
56MYB_26560356_Chip-Seq_TH2_Human1.92137029
57ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.91464132
58TCF7_22412390_ChIP-Seq_EML_Mouse1.91117719
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.90582124
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.90253914
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.87449828
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.87146306
63MAF_26560356_Chip-Seq_TH2_Human1.82268393
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.82110461
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.81669867
66KDM2B_26808549_Chip-Seq_DND41_Human1.79242422
67SOX2_20726797_ChIP-Seq_SW620_Human1.79157570
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79029348
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.73797813
70CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.73663329
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.73365757
72LXR_22292898_ChIP-Seq_THP-1_Human1.72620399
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71290048
74* MYB_26560356_Chip-Seq_TH1_Human1.70534871
75* BRD4_25478319_ChIP-Seq_HGPS_Human1.69449887
76Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.69422404
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.68940364
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66417288
79ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.64535945
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.64446550
81* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64407164
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.61409653
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.60122588
84NRF2_20460467_ChIP-Seq_MEFs_Mouse1.60122588
85VDR_24787735_ChIP-Seq_THP-1_Human1.57452696
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.54709586
87UBF1/2_26484160_Chip-Seq_HMECs_Human1.53237629
88GATA1_19941827_ChIP-Seq_MEL_Mouse1.52687576
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.50979253
90GATA2_21666600_ChIP-Seq_HMVEC_Human1.50180561
91KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48640575
92KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48640575
93KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48640575
94* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48390673
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48261663
96SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47655427
97ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.46662895
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46288696
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46055249
100* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45128363
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42799411
102TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41639673
103GATA3_27048872_Chip-Seq_THYMUS_Human1.40590656
104TCF3_18692474_ChIP-Seq_MEFs_Mouse1.39988193
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39879216
106* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37893650
107EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.37737056
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37305877
109TP53_22127205_ChIP-Seq_IMR90_Human1.37282426
110SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37086085
111BCL6_27268052_Chip-Seq_Bcells_Human1.35956552
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35848386
113GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34014246
114ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33331485
115* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32797016
116* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32394326
117TP53_18474530_ChIP-ChIP_U2OS_Human1.32069648
118MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.31401357
119SMC1_22415368_ChIP-Seq_MEFs_Mouse1.31204556
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30062106
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30009156
122BCOR_27268052_Chip-Seq_Bcells_Human1.29617820
123PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28227432
124RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27857074
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27108477
126RACK7_27058665_Chip-Seq_MCF-7_Human1.26046590
127GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26041838
128TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25992176
129GATA1_19941826_ChIP-Seq_K562_Human1.25155564
130EP300_21415370_ChIP-Seq_HL-1_Mouse1.24903639
131* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24647377
132SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23725634
133SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.22304755
134PU_27001747_Chip-Seq_BMDM_Mouse1.18712697
135ATF3_27146783_Chip-Seq_COLON_Human1.18458258
136KDM2B_26808549_Chip-Seq_JURKAT_Human1.17685085
137* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16424755
138ELK1_22589737_ChIP-Seq_MCF10A_Human1.16231371
139VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15921336
140PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13634456
141KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11725572
142TP53_16413492_ChIP-PET_HCT116_Human1.11590926
143GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11379905
144PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11054108
145HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10853798
146ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10209739
147STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09820611
148WT1_19549856_ChIP-ChIP_CCG9911_Human1.09068720
149JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08405689
150TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08246124
151FOXO3_23340844_ChIP-Seq_DLD1_Human1.08242445
152CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07566424
153PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07132620
154UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06938090
155GATA3_24758297_ChIP-Seq_MCF-7_Human1.05226329
156GATA3_26560356_Chip-Seq_TH2_Human1.03680393
157SA1_27219007_Chip-Seq_ERYTHROID_Human1.03634888
158SMAD_19615063_ChIP-ChIP_OVARY_Human1.03502843
159TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02236017
160GATA6_25053715_ChIP-Seq_YYC3_Human1.02156526
161ELF1_20517297_ChIP-Seq_JURKAT_Human1.01724616
162SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01530771
163P68_20966046_ChIP-Seq_HELA_Human1.01090209
164* SPI1_20517297_ChIP-Seq_HL60_Human0.99788862
165TP63_19390658_ChIP-ChIP_HaCaT_Human0.99074955
166SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98545268
167CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98231444
168POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97903349
169PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97485686
170DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94600529
171NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94408547
172NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94221514
173ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93731728
174P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93206194
175RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92991656
176NFI_21473784_ChIP-Seq_ESCs_Mouse0.92696683
177SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90222090
178SA1_22415368_ChIP-Seq_MEFs_Mouse0.90171495
179ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90111303
180GATA2_19941826_ChIP-Seq_K562_Human0.89651898
181KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88725124
182NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88424406
183SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87993072
184TP53_23651856_ChIP-Seq_MEFs_Mouse0.87617602
185KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87302141
186JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87064226
187GATA4_25053715_ChIP-Seq_YYC3_Human0.86728731
188NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85008127
189NCOR1_26117541_ChIP-Seq_K562_Human0.84743610

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology5.15297299
2MP0003724_increased_susceptibility_to4.92236150
3MP0003436_decreased_susceptibility_to4.37154960
4MP0003303_peritoneal_inflammation3.75686503
5MP0001835_abnormal_antigen_presentation3.72408798
6MP0002139_abnormal_hepatobiliary_system3.59624753
7MP0003705_abnormal_hypodermis_morpholog3.45816134
8MP0006082_CNS_inflammation3.35753895
9MP0002419_abnormal_innate_immunity3.23929760
10MP0003279_aneurysm3.04924231
11MP0002138_abnormal_hepatobiliary_system2.92598649
12MP0005025_abnormal_response_to2.92058804
13MP0008438_abnormal_cutaneous_collagen2.90438451
14MP0009785_altered_susceptibility_to2.90065413
15MP0005671_abnormal_response_to2.89976837
16MP0001790_abnormal_immune_system2.85912732
17MP0005387_immune_system_phenotype2.85912732
18MP0005000_abnormal_immune_tolerance2.84117148
19MP0010368_abnormal_lymphatic_system2.74836294
20MP0001800_abnormal_humoral_immune2.72930104
21MP0004272_abnormal_basement_membrane2.70734978
22MP0000685_abnormal_immune_system2.70330491
23MP0009384_cardiac_valve_regurgitation2.67741488
24MP0003300_gastrointestinal_ulcer2.56713695
25MP0005503_abnormal_tendon_morphology2.55755189
26MP0002723_abnormal_immune_serum2.53822995
27MP0002452_abnormal_antigen_presenting2.45127232
28MP0002420_abnormal_adaptive_immunity2.43558699
29MP0001819_abnormal_immune_cell2.41618803
30MP0005623_abnormal_meninges_morphology2.37515291
31MP0002148_abnormal_hypersensitivity_rea2.37436503
32MP0000566_synostosis2.35798106
33MP0005257_abnormal_intraocular_pressure2.32568033
34MP0003385_abnormal_body_wall2.31957874
35MP0005464_abnormal_platelet_physiology2.28422480
36MP0000767_abnormal_smooth_muscle2.27099124
37MP0001533_abnormal_skeleton_physiology2.26275491
38* MP0002928_abnormal_bile_duct2.24606768
39MP0003566_abnormal_cell_adhesion2.14173081
40MP0002009_preneoplasia2.08592730
41MP0001879_abnormal_lymphatic_vessel2.07828396
42MP0002405_respiratory_system_inflammati2.05557043
43* MP0005084_abnormal_gallbladder_morpholo2.03596282
44MP0005058_abnormal_lysosome_morphology1.98162964
45MP0003941_abnormal_skin_development1.96349513
46* MP0003943_abnormal_hepatobiliary_system1.92553771
47MP0009840_abnormal_foam_cell1.88200768
48MP0003806_abnormal_nucleotide_metabolis1.87496397
49MP0003172_abnormal_lysosome_physiology1.84820945
50MP0005508_abnormal_skeleton_morphology1.83588405
51MP0010155_abnormal_intestine_physiology1.81401231
52MP0003252_abnormal_bile_duct1.79513351
53MP0001845_abnormal_inflammatory_respons1.77277700
54MP0003011_delayed_dark_adaptation1.76585381
55MP0000716_abnormal_immune_system1.76395086
56MP0002132_abnormal_respiratory_system1.75009397
57MP0002398_abnormal_bone_marrow1.73788636
58MP0000534_abnormal_ureter_morphology1.71301627
59MP0005023_abnormal_wound_healing1.71215315
60MP0003763_abnormal_thymus_physiology1.70679733
61MP0009278_abnormal_bone_marrow1.70526972
62MP0004510_myositis1.69720849
63MP0003183_abnormal_peptide_metabolism1.67737263
64MP0009053_abnormal_anal_canal1.66772757
65MP0006054_spinal_hemorrhage1.64272882
66* MP0005085_abnormal_gallbladder_physiolo1.62624166
67MP0003122_maternal_imprinting1.61199625
68MP0003942_abnormal_urinary_system1.60229157
69MP0008260_abnormal_autophagy1.59297952
70MP0000465_gastrointestinal_hemorrhage1.58505280
71MP0004947_skin_inflammation1.58496665
72MP0005275_abnormal_skin_tensile1.57002475
73MP0002282_abnormal_trachea_morphology1.56297651
74MP0001958_emphysema1.55799917
75MP0009333_abnormal_splenocyte_physiolog1.53090324
76MP0008469_abnormal_protein_level1.52793758
77MP0002295_abnormal_pulmonary_circulatio1.51146383
78MP0000689_abnormal_spleen_morphology1.49677871
79MP0003828_pulmonary_edema1.45423461
80MP0009764_decreased_sensitivity_to1.45307022
81MP0002722_abnormal_immune_system1.44567288
82MP0003115_abnormal_respiratory_system1.41880395
83MP0001851_eye_inflammation1.41646902
84MP0003866_abnormal_defecation1.41585336
85MP0005310_abnormal_salivary_gland1.39636382
86MP0002932_abnormal_joint_morphology1.39255382
87MP0002429_abnormal_blood_cell1.38108931
88MP0000762_abnormal_tongue_morphology1.37830079
89MP0000343_altered_response_to1.35839965
90MP0002998_abnormal_bone_remodeling1.34546330
91MP0003075_altered_response_to1.32015899
92MP0003690_abnormal_glial_cell1.30337843
93MP0006138_congestive_heart_failure1.30073774
94MP0003091_abnormal_cell_migration1.28974412
95MP0002877_abnormal_melanocyte_morpholog1.28256629
96MP0000013_abnormal_adipose_tissue1.26093721
97MP0001915_intracranial_hemorrhage1.26081311
98MP0002277_abnormal_respiratory_mucosa1.25381661
99MP0005197_abnormal_uvea_morphology1.24950901
100MP0003123_paternal_imprinting1.22838954
101MP0008004_abnormal_stomach_pH1.22808211
102MP0000703_abnormal_thymus_morphology1.19672203
103MP0003937_abnormal_limbs/digits/tail_de1.18662594
104MP0003191_abnormal_cellular_cholesterol1.09927886
105MP0008007_abnormal_cellular_replicative1.09758745
106MP0005451_abnormal_body_composition1.09744985
107MP0000163_abnormal_cartilage_morphology1.09539893
108MP0000049_abnormal_middle_ear1.07897049
109MP0001545_abnormal_hematopoietic_system1.06309413
110MP0005397_hematopoietic_system_phenotyp1.06309413
111MP0004381_abnormal_hair_follicle1.05722892
112MP0008775_abnormal_heart_ventricle1.04706055
113MP0006292_abnormal_olfactory_placode1.02799835
114MP0005390_skeleton_phenotype1.02616282
115MP0001849_ear_inflammation1.02454570
116MP0001614_abnormal_blood_vessel1.01948370
117MP0001986_abnormal_taste_sensitivity1.00885095
118MP0002925_abnormal_cardiovascular_devel0.99538106
119MP0001243_abnormal_dermal_layer0.98925041
120MP0003448_altered_tumor_morphology0.97928141
121MP0009250_abnormal_appendicular_skeleto0.97834923
122MP0005166_decreased_susceptibility_to0.97347226
123MP0002396_abnormal_hematopoietic_system0.97015219
124MP0001663_abnormal_digestive_system0.96799409
125MP0000604_amyloidosis0.96152338
126MP0004130_abnormal_muscle_cell0.94816480
127MP0002128_abnormal_blood_circulation0.94572828
128MP0005388_respiratory_system_phenotype0.92626160
129MP0002133_abnormal_respiratory_system0.92626160
130MP0004883_abnormal_blood_vessel0.91214404
131MP0009672_abnormal_birth_weight0.91098102
132MP0002249_abnormal_larynx_morphology0.91023302
133MP0003755_abnormal_palate_morphology0.90353772
134MP0010630_abnormal_cardiac_muscle0.89386809
135MP0005595_abnormal_vascular_smooth0.89120192
136MP0000537_abnormal_urethra_morphology0.88182423
137MP0005164_abnormal_response_to0.88054278
138MP0009763_increased_sensitivity_to0.87468586
139MP0001299_abnormal_eye_distance/0.87076748
140MP0002938_white_spotting0.85460005
141MP0002233_abnormal_nose_morphology0.84747701
142MP0004134_abnormal_chest_morphology0.84323547
143MP0002060_abnormal_skin_morphology0.84316341
144MP0004808_abnormal_hematopoietic_stem0.83943864
145MP0004197_abnormal_fetal_growth/weight/0.83401026
146MP0001853_heart_inflammation0.81790213
147MP0000003_abnormal_adipose_tissue0.81344339
148MP0000490_abnormal_crypts_of0.80956125
149MP0003935_abnormal_craniofacial_develop0.80149102
150MP0005248_abnormal_Harderian_gland0.79128171
151MP0000858_altered_metastatic_potential0.78618915
152MP0000266_abnormal_heart_morphology0.78585942
153MP0001784_abnormal_fluid_regulation0.78548694
154MP0004233_abnormal_muscle_weight0.77242712
155MP0000733_abnormal_muscle_development0.77169083
156MP0002092_abnormal_eye_morphology0.76601180
157MP0001177_atelectasis0.76527892
158MP0003984_embryonic_growth_retardation0.75748320
159MP0001873_stomach_inflammation0.75515946
160MP0002088_abnormal_embryonic_growth/wei0.75032125
161MP0003119_abnormal_digestive_system0.74348212
162MP0000678_abnormal_parathyroid_gland0.74254125
163MP0002933_joint_inflammation0.73518473
164MP0002086_abnormal_extraembryonic_tissu0.71569379
165MP0002113_abnormal_skeleton_development0.71390579
166MP0002127_abnormal_cardiovascular_syste0.71362486
167MP0001175_abnormal_lung_morphology0.70848730
168MP0000249_abnormal_blood_vessel0.67755101
169MP0003795_abnormal_bone_structure0.62859043
170MP0009765_abnormal_xenobiotic_induced0.62591206
171MP0005666_abnormal_adipose_tissue0.60379230
172MP0005319_abnormal_enzyme/_coenzyme0.56443339
173MP0004858_abnormal_nervous_system0.55996744
174MP0003221_abnormal_cardiomyocyte_apopto0.55678863
175MP0005167_abnormal_blood-brain_barrier0.54293003
176MP0005075_abnormal_melanosome_morpholog0.53255585
177MP0000015_abnormal_ear_pigmentation0.53069272
178MP0001542_abnormal_bone_strength0.52681708
179* MP0008874_decreased_physiological_sensi0.52574423
180MP0005377_hearing/vestibular/ear_phenot0.52357929
181MP0003878_abnormal_ear_physiology0.52357929
182MP0005381_digestive/alimentary_phenotyp0.51358512
183MP0002166_altered_tumor_susceptibility0.50842516
184MP0002971_abnormal_brown_adipose0.50751604
185MP0005535_abnormal_body_temperature0.50346570

Predicted human phenotypes

RankGene SetZ-score
1Abnormal pancreas size (HP:0012094)7.06263731
2Eczematoid dermatitis (HP:0000976)6.83698512
3Recurrent abscess formation (HP:0002722)6.30267133
4Recurrent bacterial skin infections (HP:0005406)6.10468694
5Abnormality of macrophages (HP:0004311)5.99795384
6Myositis (HP:0100614)5.67414465
7Recurrent gram-negative bacterial infections (HP:0005420)5.49962735
8Orchitis (HP:0100796)5.21696268
9Stomatitis (HP:0010280)4.99140980
10Retrobulbar optic neuritis (HP:0100654)4.81099357
11Optic neuritis (HP:0100653)4.81099357
12Elevated erythrocyte sedimentation rate (HP:0003565)4.55608336
13Vertebral arch anomaly (HP:0008438)4.39175951
14Chorioretinal atrophy (HP:0000533)4.31728856
15Spontaneous hematomas (HP:0007420)4.24648746
16Obstructive lung disease (HP:0006536)4.11079499
17Chronic obstructive pulmonary disease (HP:0006510)4.11079499
18Pulmonary artery stenosis (HP:0004415)4.10811487
19Mediastinal lymphadenopathy (HP:0100721)4.02132886
20Recurrent fungal infections (HP:0002841)3.97669021
21Recurrent skin infections (HP:0001581)3.95905928
22Aortic aneurysm (HP:0004942)3.94921289
23Gastrointestinal infarctions (HP:0005244)3.92487946
24Short nail (HP:0001799)3.90042749
25Meningitis (HP:0001287)3.84057891
26Premature rupture of membranes (HP:0001788)3.83349609
27Prolonged bleeding time (HP:0003010)3.79181312
28Spinal cord lesions (HP:0100561)3.78294994
29Syringomyelia (HP:0003396)3.78294994
30Prolonged neonatal jaundice (HP:0006579)3.73902684
31Hypochromic microcytic anemia (HP:0004840)3.69038007
32Abnormal delayed hypersensitivity skin test (HP:0002963)3.68626441
33Protrusio acetabuli (HP:0003179)3.62255925
34Gingivitis (HP:0000230)3.52779858
35Encephalitis (HP:0002383)3.47706568
36Increased IgE level (HP:0003212)3.46382292
37Urticaria (HP:0001025)3.42979872
38Keratoconjunctivitis sicca (HP:0001097)3.41623160
39Recurrent cutaneous fungal infections (HP:0011370)3.41437207
40Chronic mucocutaneous candidiasis (HP:0002728)3.41437207
41Glucose intolerance (HP:0000833)3.40344545
42Anterior segment dysgenesis (HP:0007700)3.38203305
43Mesomelia (HP:0003027)3.37384900
44Hypochromic anemia (HP:0001931)3.35641639
45Papillary thyroid carcinoma (HP:0002895)3.33449396
46Petechiae (HP:0000967)3.27515433
47Periauricular skin pits (HP:0100277)3.26167026
48Preauricular pit (HP:0004467)3.26167026
49Vasculitis (HP:0002633)3.26014188
50Long nose (HP:0003189)3.21318991
51Exocrine pancreatic insufficiency (HP:0001738)3.16736632
52Keratoconjunctivitis (HP:0001096)3.15232485
53Episodic fever (HP:0001954)3.14314109
54Bicornuate uterus (HP:0000813)3.07016568
55Shawl scrotum (HP:0000049)3.05439698
56Epistaxis (HP:0000421)3.04313872
57Gingival bleeding (HP:0000225)3.03246906
58Purpura (HP:0000979)3.03135184
59Amyloidosis (HP:0011034)2.99893524
60Cellulitis (HP:0100658)2.98782641
61Hemoptysis (HP:0002105)2.96454072
62Chest pain (HP:0100749)2.93441736
63Unilateral renal agenesis (HP:0000122)2.86423406
64Cerebral aneurysm (HP:0004944)2.86133624
65Abnormality of glycolipid metabolism (HP:0010969)2.81724538
66Abnormality of liposaccharide metabolism (HP:0010968)2.81724538
67Abnormality of glycosphingolipid metabolism (HP:0004343)2.81724538
68Increased cerebral lipofuscin (HP:0011813)2.81175852
69Pulmonary infiltrates (HP:0002113)2.80884173
70Inflammation of the large intestine (HP:0002037)2.79130971
71Wormian bones (HP:0002645)2.74151830
72Increased IgM level (HP:0003496)2.71153225
73Renal tubular acidosis (HP:0001947)2.70214364
7411 pairs of ribs (HP:0000878)2.69896642
75Gastrointestinal inflammation (HP:0004386)2.69510275
76Anorexia (HP:0002039)2.65507844
77Renal hypoplasia (HP:0000089)2.65038213
78Hepatoblastoma (HP:0002884)2.64979487
79Pustule (HP:0200039)2.62161908
80Abnormality of dentin (HP:0010299)2.61447283
81Radial bowing (HP:0002986)2.61091797
82Short hallux (HP:0010109)2.60542032
83Leukocytosis (HP:0001974)2.58423634
84Gout (HP:0001997)2.57913306
85Aortic dissection (HP:0002647)2.57778754
86Right ventricular cardiomyopathy (HP:0011663)2.56580812
87Pulmonary embolism (HP:0002204)2.55654686
88Aplasia/Hypoplasia of the hallux (HP:0008362)2.54136963
89Distal lower limb muscle weakness (HP:0009053)2.54133349
90Fibular hypoplasia (HP:0003038)2.53756220
91Annular pancreas (HP:0001734)2.52306310
92Loss of speech (HP:0002371)2.52215930
93Abnormality of the phalanges of the 2nd finger (HP:0009541)2.51069223
94Recurrent viral infections (HP:0004429)2.49025539
95Arterial thrombosis (HP:0004420)2.47942868
96Renal duplication (HP:0000075)2.47461774
97Increased serum ferritin (HP:0003281)2.47022742
98Vascular tortuosity (HP:0004948)2.46804132
99Microcytic anemia (HP:0001935)2.40870436
100Abnormal glucose tolerance (HP:0001952)2.40645516
101Panhypogammaglobulinemia (HP:0003139)2.40609972
102Renal dysplasia (HP:0000110)2.39915389
103Broad toe (HP:0001837)2.37673071
104Blue sclerae (HP:0000592)2.37070949
105Abnormal platelet volume (HP:0011876)2.37055284
106Dilatation of the ascending aorta (HP:0005111)2.36035588
107T lymphocytopenia (HP:0005403)2.35116355
108Osteomyelitis (HP:0002754)2.33078775
109Broad distal phalanx of finger (HP:0009836)2.32483471
110Hepatocellular carcinoma (HP:0001402)2.32081593
111Dysostosis multiplex (HP:0000943)2.31725379
112Abnormality of T cell number (HP:0011839)2.30263347
113Diastasis recti (HP:0001540)2.29756328
114Spinal rigidity (HP:0003306)2.27595630
115Colitis (HP:0002583)2.27350958
116Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.27098439
117Increased neuronal autofluorescent lipopigment (HP:0002074)2.24750745
118Abnormality of iron homeostasis (HP:0011031)2.24262012
119Hepatosplenomegaly (HP:0001433)2.23312104
120Soft skin (HP:0000977)2.23287337
121Abnormality of the pleura (HP:0002103)2.21937471
122Lymphopenia (HP:0001888)2.20602139
123Mitral regurgitation (HP:0001653)2.20296423
124Deformed tarsal bones (HP:0008119)2.19372354
125Hypergammaglobulinemia (HP:0010702)2.18617995
126Premature loss of primary teeth (HP:0006323)2.16845784
127Skin pits (HP:0100276)2.15453794
128Systemic lupus erythematosus (HP:0002725)2.15367967
129Missing ribs (HP:0000921)2.14920012
130Shallow orbits (HP:0000586)2.14093539
131Progressive sensorineural hearing impairment (HP:0000408)2.13140146
132Sepsis (HP:0100806)2.13060578
133Increased connective tissue (HP:0009025)2.12819060
134Hypercholesterolemia (HP:0003124)2.12610551
135Malnutrition (HP:0004395)2.12442176
136Abnormality of T cells (HP:0002843)2.12291678
137Nonimmune hydrops fetalis (HP:0001790)2.11742205
138Abnormality of the anterior chamber (HP:0000593)2.11585763
139Abnormality of the middle phalanges of the toes (HP:0010183)2.11420700
140Granulocytopenia (HP:0001913)2.11107677
141Bowed forearm bones (HP:0003956)2.11063667
142Bowing of the arm (HP:0006488)2.11063667
143Disinhibition (HP:0000734)2.11053549
144Peritonitis (HP:0002586)2.09188912
145Abnormality of the distal phalanges of the toes (HP:0010182)2.08379658
146Vertigo (HP:0002321)2.07673569
147Polyneuropathy (HP:0001271)2.06561408
148Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.06553685
149Fragile skin (HP:0001030)2.05920852
150Glomerulopathy (HP:0100820)2.05059241
151Gangrene (HP:0100758)2.04577516
152Upper motor neuron abnormality (HP:0002127)2.03477976
153Abnormality of cells of the lymphoid lineage (HP:0012140)2.03021933
154Polycythemia (HP:0001901)1.99138917
155Ankle contracture (HP:0006466)1.98456021
156Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.98117170
157Short 4th metacarpal (HP:0010044)1.98117170
158Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.96648559
159Hypoplasia of the uterus (HP:0000013)1.96300047
160Abnormal hemoglobin (HP:0011902)1.95966712
161Thyroid carcinoma (HP:0002890)1.95128864
162Vacuolated lymphocytes (HP:0001922)1.94090775
163Skin ulcer (HP:0200042)1.94043305
164Hematochezia (HP:0002573)1.93923597
165Acne (HP:0001061)1.93782001
166Ureteral stenosis (HP:0000071)1.92325237
167Abnormality of the endocardium (HP:0004306)1.91930390
168Hemivertebrae (HP:0002937)1.91472478
169Abnormality of the pericardium (HP:0001697)1.91307424
170Hypoplasia of the ulna (HP:0003022)1.90848690
171Abnormality of T cell physiology (HP:0011840)1.90067112
172Asymmetry of the thorax (HP:0001555)1.89709610
173Broad metatarsal (HP:0001783)1.89302062
174Abnormality of the peritoneum (HP:0002585)1.89301263
175Chondrocalcinosis (HP:0000934)1.88483500
176Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87779649
177Atrophic scars (HP:0001075)1.87511805
178Abnormality of the 2nd finger (HP:0004100)1.87464369
179Hypertriglyceridemia (HP:0002155)1.87017922
180Stillbirth (HP:0003826)1.86503141
181Recurrent pneumonia (HP:0006532)1.84530947
182Cheilitis (HP:0100825)1.84129719
183Aplasia/Hypoplasia of the fibula (HP:0006492)1.83829465
184Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83730415
185Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83730415
186Biconcave vertebral bodies (HP:0004586)1.81744028
187Ureteral obstruction (HP:0006000)1.81362267
188Femoral bowing (HP:0002980)1.81171768
189Bladder diverticulum (HP:0000015)1.80750053
190Abnormality of the calcaneus (HP:0008364)1.80232267
191Abnormality of the proximal phalanges of the hand (HP:0009834)1.80018867
192Abnormality of Sharpey fibers (HP:0100685)1.78402793
193Fibular aplasia (HP:0002990)1.77841202
194Pancreatic islet-cell hyperplasia (HP:0004510)1.77228114
195Hallux valgus (HP:0001822)1.73870062
196Coarctation of aorta (HP:0001680)1.73545206
197Distal lower limb amyotrophy (HP:0008944)1.73413674
198Vertebral compression fractures (HP:0002953)1.73162545
199Broad phalanges of the hand (HP:0009768)1.71655551

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.99595828
2TAOK23.83040736
3ZAK3.82774355
4LATS13.65119126
5MAP4K13.51564000
6ERN13.43693116
7BLK3.27555700
8EPHA33.04018190
9IRAK42.90143335
10FRK2.86680534
11CSK2.81262892
12MAP3K32.74720057
13CLK12.67243133
14FES2.61890378
15TNK22.57671368
16NUAK12.42659788
17LATS22.36704066
18TRPM72.33646770
19ERBB32.28601578
20MAP2K32.28150539
21ZAP702.22212119
22GRK62.13196935
23MYLK2.10416002
24TESK12.09030048
25TTN1.93321822
26LIMK11.93020649
27FGR1.88018873
28BTK1.87914303
29EPHB21.83723339
30EPHA21.79625501
31HCK1.76767575
32PKN21.76225718
33PAK21.67909853
34MAP3K141.66284122
35SYK1.65201487
36TESK21.64537750
37TRIB31.57806084
38TBK11.47561519
39PDGFRA1.46994810
40MET1.46054129
41TXK1.42813401
42PTK61.41429801
43PTK21.36272434
44IKBKE1.35387301
45LYN1.35053507
46CSF1R1.34972029
47PIK3CA1.33685366
48TAOK11.32278986
49PIM21.28103018
50TGFBR11.26442268
51JAK21.26404831
52EIF2AK31.26100981
53RIPK11.26037070
54MAP3K11.18921084
55JAK11.16167852
56LCK1.15871090
57PTK2B1.15764334
58KSR21.14600940
59DDR21.13434268
60FLT31.13144597
61MARK21.10534594
62STK101.09177706
63PRKD21.09089492
64FGFR11.08131249
65PAK41.06316555
66PDPK11.02191938
67YES11.01729796
68PDK11.01224532
69NEK61.00711316
70CDK121.00590352
71ITK0.98720585
72PAK30.96687471
73MARK30.94508755
74SIK20.93543778
75IKBKB0.93174948
76ROCK10.92715028
77EPHB10.92659189
78TEC0.92117174
79MAP3K130.91914643
80JAK30.90739266
81TAOK30.90326289
82CDK190.88433742
83PRKG20.87670632
84LRRK20.87492706
85MAP3K80.87382101
86MATK0.86806699
87RPS6KA40.85514540
88MAP3K60.81022469
89ERBB40.80737314
90TLK10.80247359
91SIK30.79013188
92ILK0.78880615
93MAP3K100.71560584
94SIK10.71301767
95MAPK120.71295644
96MAP3K70.68006562
97BCR0.67650750
98FYN0.67035793
99PLK20.66599425
100PRPF4B0.66465621
101CAMKK20.65130782
102MAP2K40.63583242
103DAPK30.63291762
104IRAK20.62553838
105MAPK70.61979948
106CDC42BPA0.60896962
107PDGFRB0.60354124
108KDR0.59408326
109FGFR20.58845244
110IRAK10.56810687
111PRKCQ0.56740991
112TSSK60.56170933
113BMX0.56003439
114CDK80.55760700
115ROCK20.54697841
116BMPR20.53520814
117STK110.52888763
118STK30.52785490
119SCYL20.52658598
120TIE10.52154667
121DYRK1B0.50988409
122MTOR0.49506030
123AKT30.49191989
124TGFBR20.48994688
125GRK70.48779367
126ABL20.48767541
127CAMKK10.48397431
128RPS6KC10.47339167
129RPS6KL10.47339167
130NME10.46481434
131MAP3K50.45760703
132CHUK0.45594493
133CHEK20.45325224
134MAP3K110.44388171
135RPS6KB20.44211228
136HIPK20.43451263
137SMG10.42764483
138NTRK10.41929002
139ARAF0.40530622
140INSR0.40514550
141MOS0.40111575
142PLK30.40110434
143RPS6KA60.39980859
144DAPK20.38690308
145RET0.38493695
146STK380.37994514
147RAF10.37685742
148MAPKAPK50.37385359
149SGK20.36869660
150PIK3CG0.36759832
151PAK10.35468343
152TYK20.35131719
153SRPK10.34443250
154BRD40.34004644
155DMPK0.32524399
156CDK180.31486147
157PRKCD0.31030136
158RPS6KA20.30987953
159SGK30.30867294
160FGFR40.30638245
161MAP3K20.30309230
162MAP2K60.29807330
163CDK60.28987414
164CDK150.27943468
165CDK140.26585427
166MAPKAPK20.26391658
167PRKD10.25888507
168KIT0.25807682
169FER0.25650033

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043803.22204590
2Staphylococcus aureus infection_Homo sapiens_hsa051503.03338476
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.02079438
4Chronic myeloid leukemia_Homo sapiens_hsa052202.40951309
5Graft-versus-host disease_Homo sapiens_hsa053322.39914675
6Allograft rejection_Homo sapiens_hsa053302.36890074
7TGF-beta signaling pathway_Homo sapiens_hsa043502.33064462
8Hippo signaling pathway_Homo sapiens_hsa043902.32872320
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.30222902
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.23230854
11Tuberculosis_Homo sapiens_hsa051522.21374372
12Focal adhesion_Homo sapiens_hsa045102.21024845
13Autoimmune thyroid disease_Homo sapiens_hsa053202.18612573
14Proteoglycans in cancer_Homo sapiens_hsa052052.16180642
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.12236988
16ECM-receptor interaction_Homo sapiens_hsa045122.11765434
17Adherens junction_Homo sapiens_hsa045202.10730888
18B cell receptor signaling pathway_Homo sapiens_hsa046622.10345930
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04148772
20Protein export_Homo sapiens_hsa030602.02358361
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.99227057
22Notch signaling pathway_Homo sapiens_hsa043301.99091951
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.93376607
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.89269355
25Primary immunodeficiency_Homo sapiens_hsa053401.87894105
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.87360074
27Dilated cardiomyopathy_Homo sapiens_hsa054141.85800232
28Small cell lung cancer_Homo sapiens_hsa052221.81514232
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.79235760
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.78952733
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.78877349
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.76101462
33Other glycan degradation_Homo sapiens_hsa005111.75760956
34Bladder cancer_Homo sapiens_hsa052191.74340498
35Chemokine signaling pathway_Homo sapiens_hsa040621.73040183
36Type I diabetes mellitus_Homo sapiens_hsa049401.71115115
37Hematopoietic cell lineage_Homo sapiens_hsa046401.70396065
38Antigen processing and presentation_Homo sapiens_hsa046121.69124554
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.68170238
40Phenylalanine metabolism_Homo sapiens_hsa003601.59873489
41Shigellosis_Homo sapiens_hsa051311.57435900
42Regulation of actin cytoskeleton_Homo sapiens_hsa048101.57229255
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57080950
44Measles_Homo sapiens_hsa051621.56479402
45MicroRNAs in cancer_Homo sapiens_hsa052061.56230835
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.55449239
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.49865247
48Glutathione metabolism_Homo sapiens_hsa004801.47505894
49T cell receptor signaling pathway_Homo sapiens_hsa046601.46940500
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41133009
51Prostate cancer_Homo sapiens_hsa052151.39179434
52Intestinal immune network for IgA production_Homo sapiens_hsa046721.36914103
53Leishmaniasis_Homo sapiens_hsa051401.32451220
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.32356730
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32096463
56African trypanosomiasis_Homo sapiens_hsa051431.31214979
57Tight junction_Homo sapiens_hsa045301.30787878
58Systemic lupus erythematosus_Homo sapiens_hsa053221.30652018
59Basal cell carcinoma_Homo sapiens_hsa052171.30223306
60Chemical carcinogenesis_Homo sapiens_hsa052041.30134468
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28719175
62Herpes simplex infection_Homo sapiens_hsa051681.25449100
63Asthma_Homo sapiens_hsa053101.25358760
64Pertussis_Homo sapiens_hsa051331.24905105
65TNF signaling pathway_Homo sapiens_hsa046681.24018497
66Galactose metabolism_Homo sapiens_hsa000521.23178612
67Thyroid cancer_Homo sapiens_hsa052161.21182091
68Jak-STAT signaling pathway_Homo sapiens_hsa046301.20872933
69Lysosome_Homo sapiens_hsa041421.20063381
70Platelet activation_Homo sapiens_hsa046111.19848526
71Amoebiasis_Homo sapiens_hsa051461.18825805
72Rap1 signaling pathway_Homo sapiens_hsa040151.15746116
73Toxoplasmosis_Homo sapiens_hsa051451.12366988
74Rheumatoid arthritis_Homo sapiens_hsa053231.11889495
75HTLV-I infection_Homo sapiens_hsa051661.10376539
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09993409
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09956813
78Viral myocarditis_Homo sapiens_hsa054161.09795314
79Pathways in cancer_Homo sapiens_hsa052001.05456401
80Pancreatic cancer_Homo sapiens_hsa052121.01834991
81Viral carcinogenesis_Homo sapiens_hsa052031.01422700
82PI3K-Akt signaling pathway_Homo sapiens_hsa041511.01410788
83Malaria_Homo sapiens_hsa051441.00728624
84Hepatitis C_Homo sapiens_hsa051600.97154284
85Salmonella infection_Homo sapiens_hsa051320.97062653
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.94902685
87Cell cycle_Homo sapiens_hsa041100.94850402
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91254764
89Sulfur metabolism_Homo sapiens_hsa009200.90754032
90VEGF signaling pathway_Homo sapiens_hsa043700.90300290
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90124750
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90071266
93Endocytosis_Homo sapiens_hsa041440.89138253
94Melanoma_Homo sapiens_hsa052180.88135421
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86610487
96Apoptosis_Homo sapiens_hsa042100.84969991
97p53 signaling pathway_Homo sapiens_hsa041150.82607105
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78370150
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78115910
100MAPK signaling pathway_Homo sapiens_hsa040100.76775656
101Phagosome_Homo sapiens_hsa041450.76455747
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75146724
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.74621391
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74539692
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.73900352
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.73116880
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72931312
108Glioma_Homo sapiens_hsa052140.72230903
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.71371248
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.68972447
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68195901
112Axon guidance_Homo sapiens_hsa043600.67601783
113Prolactin signaling pathway_Homo sapiens_hsa049170.67139520
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.66109452
115Alcoholism_Homo sapiens_hsa050340.65964722
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65278881
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64927710
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64897041
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60745668
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.59207014
121Inositol phosphate metabolism_Homo sapiens_hsa005620.58828277
122HIF-1 signaling pathway_Homo sapiens_hsa040660.56225851
123Tyrosine metabolism_Homo sapiens_hsa003500.55768021
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55702833
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.55240998
126Regulation of autophagy_Homo sapiens_hsa041400.55089787
127Epstein-Barr virus infection_Homo sapiens_hsa051690.54188493
128Renal cell carcinoma_Homo sapiens_hsa052110.53686152
129Wnt signaling pathway_Homo sapiens_hsa043100.52204978
130GnRH signaling pathway_Homo sapiens_hsa049120.51903489
131FoxO signaling pathway_Homo sapiens_hsa040680.50897709
132Choline metabolism in cancer_Homo sapiens_hsa052310.50279069
133Endometrial cancer_Homo sapiens_hsa052130.49820530
134Spliceosome_Homo sapiens_hsa030400.49607785
135Collecting duct acid secretion_Homo sapiens_hsa049660.49163067
136Thyroid hormone synthesis_Homo sapiens_hsa049180.48526420
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47940645
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47263721
139Type II diabetes mellitus_Homo sapiens_hsa049300.47040871
140NF-kappa B signaling pathway_Homo sapiens_hsa040640.47035366
141Legionellosis_Homo sapiens_hsa051340.47003413
142Acute myeloid leukemia_Homo sapiens_hsa052210.46342791
143Hedgehog signaling pathway_Homo sapiens_hsa043400.44812044
144Hepatitis B_Homo sapiens_hsa051610.44375463
145Non-small cell lung cancer_Homo sapiens_hsa052230.41882523
146Vibrio cholerae infection_Homo sapiens_hsa051100.41783448
147Insulin resistance_Homo sapiens_hsa049310.41614937
148Gap junction_Homo sapiens_hsa045400.41338652
149Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40676314
150Complement and coagulation cascades_Homo sapiens_hsa046100.40268591
151RNA transport_Homo sapiens_hsa030130.40207975
152Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39992057
153Protein digestion and absorption_Homo sapiens_hsa049740.38814307
154Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38097980
155Base excision repair_Homo sapiens_hsa034100.38083399
156Influenza A_Homo sapiens_hsa051640.37927500
157Colorectal cancer_Homo sapiens_hsa052100.37263310
158Dorso-ventral axis formation_Homo sapiens_hsa043200.36041972
159mTOR signaling pathway_Homo sapiens_hsa041500.35729212
160Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35687394
161Insulin signaling pathway_Homo sapiens_hsa049100.33831471
162Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33698035

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