GPBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiquitously expressed. This protein is suggested to play a role in the development of atherosclerosis. Studies in mice suggest that it may also function as a GC-rich promoter-specific trans-activating transcription factor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.91255806
2monoubiquitinated protein deubiquitination (GO:0035520)5.84814493
3mitotic sister chromatid cohesion (GO:0007064)5.26833247
4mitotic chromosome condensation (GO:0007076)5.18873481
5nuclear pore complex assembly (GO:0051292)5.15196664
6metaphase plate congression (GO:0051310)5.15121821
7nuclear pore organization (GO:0006999)4.93638393
8synapsis (GO:0007129)4.87349275
9protein localization to kinetochore (GO:0034501)4.64273060
10protein localization to chromosome, centromeric region (GO:0071459)4.49728322
11positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.48215783
12positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.48215783
13positive regulation of mitotic sister chromatid separation (GO:1901970)4.48215783
14establishment of chromosome localization (GO:0051303)4.43421324
15regulation of spindle organization (GO:0090224)4.40835479
16sister chromatid cohesion (GO:0007062)4.37313341
17meiotic chromosome segregation (GO:0045132)4.36640802
18regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.32641052
19attachment of spindle microtubules to kinetochore (GO:0008608)4.29888823
20regulation of RNA export from nucleus (GO:0046831)4.27198140
21piRNA metabolic process (GO:0034587)4.26470413
22regulation of sister chromatid cohesion (GO:0007063)4.25417736
23DNA double-strand break processing (GO:0000729)4.17992165
24kinetochore organization (GO:0051383)4.07765877
25positive regulation of chromosome segregation (GO:0051984)4.04663956
26histone H2A monoubiquitination (GO:0035518)4.01198689
27DNA replication checkpoint (GO:0000076)3.91693827
28mitotic nuclear envelope disassembly (GO:0007077)3.90091524
29regulation of meiosis I (GO:0060631)3.82830663
30mitotic sister chromatid segregation (GO:0000070)3.81494659
31pore complex assembly (GO:0046931)3.75987352
32regulation of chromosome segregation (GO:0051983)3.75842740
33protein localization to chromosome (GO:0034502)3.74194983
34membrane disassembly (GO:0030397)3.73810901
35nuclear envelope disassembly (GO:0051081)3.73810901
36sister chromatid segregation (GO:0000819)3.70496857
37neural tube formation (GO:0001841)3.70377838
38histone exchange (GO:0043486)3.70237340
39DNA replication-independent nucleosome organization (GO:0034724)3.70149986
40DNA replication-independent nucleosome assembly (GO:0006336)3.70149986
41CENP-A containing nucleosome assembly (GO:0034080)3.68057850
42negative regulation of DNA recombination (GO:0045910)3.67754871
43chromatin remodeling at centromere (GO:0031055)3.67514812
44centriole replication (GO:0007099)3.66846004
45kinetochore assembly (GO:0051382)3.64356871
46regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.63433118
47regulation of mitotic spindle checkpoint (GO:1903504)3.63433118
48spindle checkpoint (GO:0031577)3.61179396
49RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.59611827
50synaptonemal complex assembly (GO:0007130)3.55889584
51chromosome segregation (GO:0007059)3.54003975
52maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.53652965
53histone H2A acetylation (GO:0043968)3.53522214
54male meiosis (GO:0007140)3.51775128
55regulation of mitotic metaphase/anaphase transition (GO:0030071)3.50650734
56regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.44570059
57microtubule depolymerization (GO:0007019)3.44000943
58regulation of mitotic spindle organization (GO:0060236)3.41990196
59negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.41393004
60protein K6-linked ubiquitination (GO:0085020)3.41120096
61regulation of nucleobase-containing compound transport (GO:0032239)3.39794289
62negative regulation of histone methylation (GO:0031061)3.38292605
63regulation of DNA endoreduplication (GO:0032875)3.37952817
64regulation of sister chromatid segregation (GO:0033045)3.36809532
65regulation of mitotic sister chromatid separation (GO:0010965)3.36809532
66regulation of mitotic sister chromatid segregation (GO:0033047)3.36809532
67protein K11-linked deubiquitination (GO:0035871)3.35906648
68negative regulation of fibroblast apoptotic process (GO:2000270)3.30376430
69resolution of meiotic recombination intermediates (GO:0000712)3.28120568
70regulation of establishment of cell polarity (GO:2000114)3.27693078
71male meiosis I (GO:0007141)3.27502560
72synaptonemal complex organization (GO:0070193)3.27468555
73mitotic spindle checkpoint (GO:0071174)3.24644140
74somatic hypermutation of immunoglobulin genes (GO:0016446)3.23982415
75somatic diversification of immune receptors via somatic mutation (GO:0002566)3.23982415
76regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23420919
77spindle assembly checkpoint (GO:0071173)3.23394615
78negative regulation of chromosome segregation (GO:0051985)3.23007485
79meiotic nuclear division (GO:0007126)3.22975635
80negative regulation of mitotic sister chromatid segregation (GO:0033048)3.22158409
81negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.22158409
82negative regulation of sister chromatid segregation (GO:0033046)3.22158409
83negative regulation of mitotic sister chromatid separation (GO:2000816)3.22158409
84DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.21381768
85gene silencing by RNA (GO:0031047)3.21143187
86mitotic spindle assembly checkpoint (GO:0007094)3.20550002
87DNA damage response, signal transduction resulting in transcription (GO:0042772)3.19867848
88negative regulation of DNA-dependent DNA replication (GO:2000104)3.17720216
89chromosome organization involved in meiosis (GO:0070192)3.17135315
90chromatin assembly or disassembly (GO:0006333)3.16609924
91maturation of 5.8S rRNA (GO:0000460)3.15227619
92negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.15127309
93meiosis I (GO:0007127)3.14775224
94ATP-dependent chromatin remodeling (GO:0043044)3.14090002
95dosage compensation (GO:0007549)3.12301603
96retinal cone cell development (GO:0046549)3.10187038
97regulation of histone H3-K9 methylation (GO:0051570)3.09715086
98regulation of chromatin silencing (GO:0031935)3.09529901
99chromosome condensation (GO:0030261)3.07524637
100regulation of centrosome cycle (GO:0046605)3.07135000
101histone H2A ubiquitination (GO:0033522)3.05430413
102DNA synthesis involved in DNA repair (GO:0000731)3.05124032
103meiotic cell cycle process (GO:1903046)3.04085235
104snRNA transcription (GO:0009301)3.02613228
105DNA replication-dependent nucleosome assembly (GO:0006335)3.00967032
106DNA replication-dependent nucleosome organization (GO:0034723)3.00967032
107DNA methylation involved in gamete generation (GO:0043046)2.99837033
108oocyte maturation (GO:0001556)2.99740628
109somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.99683243
110isotype switching (GO:0045190)2.99683243
111somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.99683243
112purine nucleobase biosynthetic process (GO:0009113)2.95391126
113DNA packaging (GO:0006323)2.95383765
114regulation of transcription from RNA polymerase I promoter (GO:0006356)2.95048492
115replication fork processing (GO:0031297)2.94447359
116regulation of centriole replication (GO:0046599)2.94002020
117intraciliary transport (GO:0042073)2.93522817
118reciprocal meiotic recombination (GO:0007131)2.92545624
119reciprocal DNA recombination (GO:0035825)2.92545624
120negative regulation of meiosis (GO:0045835)2.91618673
121histone mRNA catabolic process (GO:0071044)2.90443006
122meiotic cell cycle (GO:0051321)2.87996881
123regulation of helicase activity (GO:0051095)2.87700280
124acrosome assembly (GO:0001675)2.85581139
125microtubule anchoring (GO:0034453)2.84893613
126positive regulation of histone H3-K4 methylation (GO:0051571)2.84258849
127negative regulation of translation, ncRNA-mediated (GO:0040033)2.83391530
128regulation of translation, ncRNA-mediated (GO:0045974)2.83391530
129negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.83391530
130double-strand break repair via homologous recombination (GO:0000724)2.82063234
131recombinational repair (GO:0000725)2.81308864
132epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72696607
133negative regulation of JUN kinase activity (GO:0043508)2.71821509
134regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.70973982
135regulation of protein glycosylation (GO:0060049)2.70877353
136postreplication repair (GO:0006301)2.64606394
137positive regulation of mRNA processing (GO:0050685)2.64061407
138response to pheromone (GO:0019236)2.63918497
139regulation of nuclear cell cycle DNA replication (GO:0033262)2.63900868
140presynaptic membrane assembly (GO:0097105)2.61211386
141positive regulation of mitochondrial fission (GO:0090141)2.60166732
142somatic recombination of immunoglobulin gene segments (GO:0016447)2.60113470
143genitalia morphogenesis (GO:0035112)2.59340110
144somatic diversification of immunoglobulins (GO:0016445)2.58521767
145protein localization to cilium (GO:0061512)2.57270030
146histone mRNA metabolic process (GO:0008334)2.56878392
147positive regulation of mRNA metabolic process (GO:1903313)2.56104380
148protein K48-linked ubiquitination (GO:0070936)2.55218784
149single strand break repair (GO:0000012)2.53546628
150exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.52538038

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.70380894
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.89691803
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.28216803
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.80661094
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.48172157
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.46497741
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.30500035
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.88866798
9IGF1R_20145208_ChIP-Seq_DFB_Human2.77533639
10AR_21909140_ChIP-Seq_LNCAP_Human2.76227787
11ZNF274_21170338_ChIP-Seq_K562_Hela2.75431414
12TAF15_26573619_Chip-Seq_HEK293_Human2.51279550
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.42930661
14* E2F1_21310950_ChIP-Seq_MCF-7_Human2.42125811
15VDR_22108803_ChIP-Seq_LS180_Human2.38406956
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.37320384
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.35963087
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.32779078
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.30887244
20GBX2_23144817_ChIP-Seq_PC3_Human2.30281236
21* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23668537
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19443566
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16832699
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.10440707
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06056401
26P300_19829295_ChIP-Seq_ESCs_Human2.05853292
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93381750
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.88403662
29* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85266238
30* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.84832332
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.84021817
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83801981
33VDR_23849224_ChIP-Seq_CD4+_Human1.83060483
34MYC_22102868_ChIP-Seq_BL_Human1.75295512
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74780132
36* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72841472
37ELK1_19687146_ChIP-ChIP_HELA_Human1.71323236
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70397986
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69548863
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67621466
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67440356
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.64957669
43ER_23166858_ChIP-Seq_MCF-7_Human1.64511653
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64108909
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.60637152
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59582553
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.56746821
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56729780
49* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56071214
50KDM5A_27292631_Chip-Seq_BREAST_Human1.55665234
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.55326664
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54735391
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52827967
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52702643
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48813939
56* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.46781353
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.46311047
58* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46094926
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45893591
60FOXP3_21729870_ChIP-Seq_TREG_Human1.44879657
61CBP_20019798_ChIP-Seq_JUKART_Human1.44794127
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44794127
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.44361013
64XRN2_22483619_ChIP-Seq_HELA_Human1.43079027
65* SMAD4_21799915_ChIP-Seq_A2780_Human1.42407582
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.39020600
67* STAT3_23295773_ChIP-Seq_U87_Human1.37965501
68* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37481207
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36978784
70CIITA_25753668_ChIP-Seq_RAJI_Human1.34205619
71BCAT_22108803_ChIP-Seq_LS180_Human1.32156104
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31434745
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31424485
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30673223
75SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.30263978
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30177518
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.29723050
78* TCF4_23295773_ChIP-Seq_U87_Human1.28843472
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25662432
80IRF1_19129219_ChIP-ChIP_H3396_Human1.25570162
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25136863
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24803321
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.24713507
84ETS1_20019798_ChIP-Seq_JURKAT_Human1.24126532
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24006156
86EZH2_22144423_ChIP-Seq_EOC_Human1.22730936
87KAP1_22055183_ChIP-Seq_ESCs_Mouse1.22481476
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.22397834
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.22201345
90* GABP_19822575_ChIP-Seq_HepG2_Human1.21481388
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20685996
92AR_25329375_ChIP-Seq_VCAP_Human1.20039218
93SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19798747
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19364003
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18038825
96* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17804119
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16763499
98FLI1_27457419_Chip-Seq_LIVER_Mouse1.16386882
99* TCF4_22108803_ChIP-Seq_LS180_Human1.16327647
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14437297
101* FLI1_21867929_ChIP-Seq_TH2_Mouse1.14187712
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14110368
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14110368
104NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13749665
105RUNX2_22187159_ChIP-Seq_PCA_Human1.12576986
106E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12311960
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11782771
108CRX_20693478_ChIP-Seq_RETINA_Mouse1.10983861
109FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10945740
110MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10781289
111PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09829580
112E2F1_18555785_Chip-Seq_ESCs_Mouse1.09571330
113SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09205327
114NANOG_21062744_ChIP-ChIP_HESCs_Human1.09204528
115NOTCH1_21737748_ChIP-Seq_TLL_Human1.09155067
116SOX2_19829295_ChIP-Seq_ESCs_Human1.08794471
117NANOG_19829295_ChIP-Seq_ESCs_Human1.08794471
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08674111
119P53_22387025_ChIP-Seq_ESCs_Mouse1.08250796
120ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08140305
121TP53_22573176_ChIP-Seq_HFKS_Human1.07516635
122PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07087366
123EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.06819485
124* RNF2_27304074_Chip-Seq_NSC_Mouse1.05232762
125FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04982791
126SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04978723
127FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04897016
128* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04896702
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04785184
130NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04648719
131SMAD_19615063_ChIP-ChIP_OVARY_Human1.03808514
132TTF2_22483619_ChIP-Seq_HELA_Human1.02982131
133CMYC_18555785_Chip-Seq_ESCs_Mouse1.02733218
134CDX2_22108803_ChIP-Seq_LS180_Human1.02699250
135FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02476946
136TAL1_26923725_Chip-Seq_HPCs_Mouse1.01917937
137P300_18555785_Chip-Seq_ESCs_Mouse1.01789029
138HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00981573
139MYB_26560356_Chip-Seq_TH1_Human0.99407682
140DCP1A_22483619_ChIP-Seq_HELA_Human0.99138740
141OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99081876
142MYB_26560356_Chip-Seq_TH2_Human0.97370330
143HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.97015884
144IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.93968354
145STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92297887
146JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.90003864
147STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.87791952
148* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87127641
149CHD1_26751641_Chip-Seq_LNCaP_Human0.85947029
150POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85448274
151FUS_26573619_Chip-Seq_HEK293_Human0.84779920
152HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.84761891
153* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84712926
154EWS_26573619_Chip-Seq_HEK293_Human0.84004916
155MYC_18940864_ChIP-ChIP_HL60_Human0.83739277
156* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.83578265
157SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83125652
158TFEB_21752829_ChIP-Seq_HELA_Human0.83053171
159* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82987197
160FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81355202
161SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.75114324
162ERG_20887958_ChIP-Seq_HPC-7_Mouse0.72885515
163STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.72157006
164SPI1_23547873_ChIP-Seq_NB4_Human0.70854397
165ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.70399134
166HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.69227547
167TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.69167090
168* TCF7_22412390_ChIP-Seq_EML_Mouse0.68089215
169CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.67632202
170MYB_21317192_ChIP-Seq_ERMYB_Mouse0.65699138

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.60094068
2MP0003693_abnormal_embryo_hatching4.29001266
3MP0010094_abnormal_chromosome_stability4.20134900
4MP0008057_abnormal_DNA_replication3.94407344
5MP0003077_abnormal_cell_cycle3.76605540
6MP0003111_abnormal_nucleus_morphology3.68371205
7MP0008007_abnormal_cellular_replicative3.37967725
8MP0004957_abnormal_blastocyst_morpholog3.33710940
9MP0008058_abnormal_DNA_repair2.99645726
10MP0003787_abnormal_imprinting2.74361745
11MP0010307_abnormal_tumor_latency2.65658474
12MP0003123_paternal_imprinting2.52568022
13MP0000350_abnormal_cell_proliferation2.29679271
14MP0001730_embryonic_growth_arrest2.28200754
15MP0003121_genomic_imprinting2.17808215
16MP0002396_abnormal_hematopoietic_system2.17609495
17MP0003880_abnormal_central_pattern2.16505865
18MP0002210_abnormal_sex_determination1.94479542
19MP0004808_abnormal_hematopoietic_stem1.92424110
20MP0005075_abnormal_melanosome_morpholog1.90402632
21MP0001929_abnormal_gametogenesis1.89749524
22MP0005076_abnormal_cell_differentiation1.88048531
23MP0004147_increased_porphyrin_level1.82543981
24MP0005380_embryogenesis_phenotype1.80259047
25MP0001672_abnormal_embryogenesis/_devel1.80259047
26MP0008932_abnormal_embryonic_tissue1.78412632
27MP0000427_abnormal_hair_cycle1.76714254
28MP0010352_gastrointestinal_tract_polyps1.70855719
29MP0001697_abnormal_embryo_size1.67691156
30MP0006072_abnormal_retinal_apoptosis1.65552591
31MP0003763_abnormal_thymus_physiology1.64939705
32MP0003984_embryonic_growth_retardation1.62140452
33MP0001188_hyperpigmentation1.61416541
34MP0002084_abnormal_developmental_patter1.59348724
35MP0002088_abnormal_embryonic_growth/wei1.58025934
36MP0000653_abnormal_sex_gland1.57632379
37MP0002877_abnormal_melanocyte_morpholog1.57409547
38MP0003718_maternal_effect1.56736065
39MP0001145_abnormal_male_reproductive1.55830284
40MP0001984_abnormal_olfaction1.55306286
41MP0002009_preneoplasia1.55015988
42MP0003786_premature_aging1.53945783
43MP0000383_abnormal_hair_follicle1.51163232
44MP0002085_abnormal_embryonic_tissue1.49707580
45MP0002086_abnormal_extraembryonic_tissu1.48733434
46MP0003890_abnormal_embryonic-extraembry1.47123410
47MP0002254_reproductive_system_inflammat1.44968464
48MP0008995_early_reproductive_senescence1.43467487
49MP0001119_abnormal_female_reproductive1.42879629
50MP0005253_abnormal_eye_physiology1.42216797
51MP0003195_calcinosis1.41673139
52MP0010678_abnormal_skin_adnexa1.35438016
53MP0005551_abnormal_eye_electrophysiolog1.33286104
54MP0002653_abnormal_ependyma_morphology1.32270600
55MP0002080_prenatal_lethality1.32045089
56MP0002638_abnormal_pupillary_reflex1.29984822
57MP0004264_abnormal_extraembryonic_tissu1.28889424
58MP0008789_abnormal_olfactory_epithelium1.27813121
59MP0002019_abnormal_tumor_incidence1.26913276
60MP0001486_abnormal_startle_reflex1.24697760
61MP0004197_abnormal_fetal_growth/weight/1.23335882
62MP0005397_hematopoietic_system_phenotyp1.23056741
63MP0001545_abnormal_hematopoietic_system1.23056741
64MP0003122_maternal_imprinting1.21550578
65MP0009333_abnormal_splenocyte_physiolog1.20772501
66MP0000647_abnormal_sebaceous_gland1.19559870
67MP0000631_abnormal_neuroendocrine_gland1.16236825
68MP0000703_abnormal_thymus_morphology1.15688475
69MP0002398_abnormal_bone_marrow1.14812813
70MP0001529_abnormal_vocalization1.14434523
71MP0000313_abnormal_cell_death1.13913926
72MP0000490_abnormal_crypts_of1.13835533
73MP0003698_abnormal_male_reproductive1.13133049
74MP0006276_abnormal_autonomic_nervous1.10847751
75MP0005174_abnormal_tail_pigmentation1.10453322
76MP0000569_abnormal_digit_pigmentation1.09905854
77MP0003937_abnormal_limbs/digits/tail_de1.09607995
78MP0005646_abnormal_pituitary_gland1.09448434
79MP0002006_tumorigenesis1.09241131
80MP0003699_abnormal_female_reproductive1.07920290
81MP0002736_abnormal_nociception_after1.06453000
82MP0005394_taste/olfaction_phenotype1.05345443
83MP0005499_abnormal_olfactory_system1.05345443
84MP0003567_abnormal_fetal_cardiomyocyte1.05334300
85MP0001501_abnormal_sleep_pattern1.03923601
86MP0002751_abnormal_autonomic_nervous1.03885448
87MP0002272_abnormal_nervous_system1.03829921
88MP0000778_abnormal_nervous_system1.03648441
89MP0002837_dystrophic_cardiac_calcinosis1.02506747
90MP0001986_abnormal_taste_sensitivity1.02029779
91MP0010234_abnormal_vibrissa_follicle1.01860814
92MP0002166_altered_tumor_susceptibility1.01486982
93MP0000372_irregular_coat_pigmentation0.97180405
94MP0006035_abnormal_mitochondrial_morpho0.95776100
95MP0005621_abnormal_cell_physiology0.95651617
96MP0005084_abnormal_gallbladder_morpholo0.95250609
97MP0009672_abnormal_birth_weight0.95079239
98MP0006292_abnormal_olfactory_placode0.94897570
99MP0005367_renal/urinary_system_phenotyp0.94003584
100MP0000516_abnormal_urinary_system0.94003584
101MP0002102_abnormal_ear_morphology0.93447449
102MP0003943_abnormal_hepatobiliary_system0.93308417
103MP0004142_abnormal_muscle_tone0.92380768
104MP0009745_abnormal_behavioral_response0.92366690
105MP0002161_abnormal_fertility/fecundity0.92078528
106MP0003136_yellow_coat_color0.91454051
107MP0002233_abnormal_nose_morphology0.90452152
108MP0002163_abnormal_gland_morphology0.89795323
109MP0009046_muscle_twitch0.89643911
110MP0004215_abnormal_myocardial_fiber0.89299384
111MP0003221_abnormal_cardiomyocyte_apopto0.86998801
112MP0005248_abnormal_Harderian_gland0.85810591
113MP0001177_atelectasis0.85729105
114MP0002722_abnormal_immune_system0.85295785
115MP0002160_abnormal_reproductive_system0.85235368
116MP0000689_abnormal_spleen_morphology0.85078372
117MP0001915_intracranial_hemorrhage0.83980109
118MP0005389_reproductive_system_phenotype0.83864596
119MP0005408_hypopigmentation0.83043166
120MP0009703_decreased_birth_body0.82571998
121MP0001968_abnormal_touch/_nociception0.81542649
122MP0003315_abnormal_perineum_morphology0.81368285
123MP0001324_abnormal_eye_pigmentation0.80923592
124MP0005645_abnormal_hypothalamus_physiol0.79212371
125MP0001849_ear_inflammation0.76930271
126MP0005384_cellular_phenotype0.76814922
127MP0003646_muscle_fatigue0.76527383
128MP0002095_abnormal_skin_pigmentation0.73145947
129MP0002090_abnormal_vision0.72624773
130MP0003935_abnormal_craniofacial_develop0.72504112
131MP0000716_abnormal_immune_system0.71980445
132MP0002735_abnormal_chemical_nociception0.70618439
133MP0000015_abnormal_ear_pigmentation0.70321736
134MP0000627_abnormal_mammary_gland0.69608521
135MP0003755_abnormal_palate_morphology0.69540852
136MP0001800_abnormal_humoral_immune0.69270192
137MP0004924_abnormal_behavior0.69003533
138MP0005386_behavior/neurological_phenoty0.69003533
139MP0009697_abnormal_copulation0.68041785
140MP0002429_abnormal_blood_cell0.67709881
141MP0001485_abnormal_pinna_reflex0.67369849
142MP0005671_abnormal_response_to0.67171796
143MP0003119_abnormal_digestive_system0.65948610
144MP0002067_abnormal_sensory_capabilities0.65619300
145MP0005187_abnormal_penis_morphology0.65376343
146MP0005310_abnormal_salivary_gland0.63491036
147MP0002925_abnormal_cardiovascular_devel0.63447779
148MP0003448_altered_tumor_morphology0.63348824
149MP0000432_abnormal_head_morphology0.63336341
150MP0001293_anophthalmia0.62877803
151MP0006054_spinal_hemorrhage0.62372002
152MP0003115_abnormal_respiratory_system0.61592276
153MP0005395_other_phenotype0.60654757
154MP0001919_abnormal_reproductive_system0.60589611
155MP0000733_abnormal_muscle_development0.59980539
156MP0005451_abnormal_body_composition0.59617089
157MP0000428_abnormal_craniofacial_morphol0.57798126
158MP0009053_abnormal_anal_canal0.57424075
159MP0003936_abnormal_reproductive_system0.57061003

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)4.48792272
2Chromsome breakage (HP:0040012)4.41928775
3Birth length less than 3rd percentile (HP:0003561)4.34590694
4Volvulus (HP:0002580)4.17656882
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.08241342
6Facial hemangioma (HP:0000329)3.65102550
7Abnormality of the fingertips (HP:0001211)3.48966822
8Abnormality of the labia minora (HP:0012880)3.39030731
9Patellar aplasia (HP:0006443)3.32866815
10Abnormality of chromosome stability (HP:0003220)3.26954971
11Acute myeloid leukemia (HP:0004808)3.25499496
12Capillary hemangiomas (HP:0005306)3.22585126
13Abnormal spermatogenesis (HP:0008669)3.10935907
14Aplasia/Hypoplasia of the patella (HP:0006498)3.08695606
15Gonadotropin excess (HP:0000837)3.07911249
16Prostate neoplasm (HP:0100787)2.96777706
17Thyroid carcinoma (HP:0002890)2.94836739
18Myelodysplasia (HP:0002863)2.88467894
19Breast hypoplasia (HP:0003187)2.84317427
20Pancreatic cysts (HP:0001737)2.81440002
21Azoospermia (HP:0000027)2.78000661
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.74407713
23Pancreatic fibrosis (HP:0100732)2.73508878
24Meckel diverticulum (HP:0002245)2.73304215
25Degeneration of the lateral corticospinal tracts (HP:0002314)2.71306370
26Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.71306370
27Abnormality of the preputium (HP:0100587)2.62739776
28Male infertility (HP:0003251)2.62402526
29Ectopic kidney (HP:0000086)2.58637917
30Shawl scrotum (HP:0000049)2.54161172
31Impulsivity (HP:0100710)2.54026955
32Medial flaring of the eyebrow (HP:0010747)2.53921839
33True hermaphroditism (HP:0010459)2.53313740
34Intestinal atresia (HP:0011100)2.53202909
35Medulloblastoma (HP:0002885)2.52822896
36Abnormality of the ileum (HP:0001549)2.52395991
37Abnormality of midbrain morphology (HP:0002418)2.52315176
38Molar tooth sign on MRI (HP:0002419)2.52315176
39Amyotrophic lateral sclerosis (HP:0007354)2.44643782
40Nephronophthisis (HP:0000090)2.40909941
41Prominent nose (HP:0000448)2.40260386
42Abnormal hair whorl (HP:0010721)2.39788315
43Chronic hepatic failure (HP:0100626)2.38631810
44Tubulointerstitial nephritis (HP:0001970)2.32402829
45Small intestinal stenosis (HP:0012848)2.28605208
46Duodenal stenosis (HP:0100867)2.28605208
47Sandal gap (HP:0001852)2.27111935
48Oligodactyly (hands) (HP:0001180)2.22645344
49Stomach cancer (HP:0012126)2.22013283
50Abnormality of the renal medulla (HP:0100957)2.20959433
51Genital tract atresia (HP:0001827)2.19662721
52Nephroblastoma (Wilms tumor) (HP:0002667)2.18891709
53Gait imbalance (HP:0002141)2.18639580
54Congenital primary aphakia (HP:0007707)2.18148524
55Colon cancer (HP:0003003)2.18073593
56Truncal obesity (HP:0001956)2.17947997
57Aplasia/Hypoplasia of the sternum (HP:0006714)2.16109142
58Aplasia/Hypoplasia of the tibia (HP:0005772)2.15981417
59Deviation of the thumb (HP:0009603)2.15926709
60Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.15640001
61Short 4th metacarpal (HP:0010044)2.15640001
62Abnormality of chromosome segregation (HP:0002916)2.15491092
63Long eyelashes (HP:0000527)2.14781456
64Oligodactyly (HP:0012165)2.14665212
65Ependymoma (HP:0002888)2.14531618
66Nephrogenic diabetes insipidus (HP:0009806)2.13615466
67Increased nuchal translucency (HP:0010880)2.12890797
68Cafe-au-lait spot (HP:0000957)2.12848497
69Methylmalonic acidemia (HP:0002912)2.11370915
70Impaired vibration sensation in the lower limbs (HP:0002166)2.09457787
71Cutaneous melanoma (HP:0012056)2.09394310
72Glioma (HP:0009733)2.09003934
73Abnormality of the corticospinal tract (HP:0002492)2.06859837
74Rhabdomyosarcoma (HP:0002859)2.06653497
75Agnosia (HP:0010524)2.06646068
76Short tibia (HP:0005736)2.05981715
77Carpal bone hypoplasia (HP:0001498)2.05921131
78Proximal placement of thumb (HP:0009623)2.05043140
79Biliary tract neoplasm (HP:0100574)2.04756526
80Sloping forehead (HP:0000340)2.02974676
81Embryonal renal neoplasm (HP:0011794)2.02605578
82Progressive inability to walk (HP:0002505)2.01611362
83Abnormality of the carotid arteries (HP:0005344)1.98856532
84Vaginal atresia (HP:0000148)1.97397304
85Abnormality of the anterior horn cell (HP:0006802)1.96167311
86Degeneration of anterior horn cells (HP:0002398)1.96167311
87Clubbing of toes (HP:0100760)1.95402426
88Cystic hygroma (HP:0000476)1.93948591
89Hyperventilation (HP:0002883)1.93494079
90Atrophy/Degeneration involving motor neurons (HP:0007373)1.93077550
91Thrombocytosis (HP:0001894)1.92947960
92Aplastic anemia (HP:0001915)1.92827027
93Pelvic girdle muscle weakness (HP:0003749)1.92249659
94Enlarged penis (HP:0000040)1.91625191
95Cortical dysplasia (HP:0002539)1.91429631
96Gaze-evoked nystagmus (HP:0000640)1.91348838
97Abnormality of the renal cortex (HP:0011035)1.88791776
98Abnormality of the prostate (HP:0008775)1.87899704
99Neoplasm of the oral cavity (HP:0100649)1.87417828
100Febrile seizures (HP:0002373)1.86430454
101Acute lymphatic leukemia (HP:0006721)1.85806575
102Blepharitis (HP:0000498)1.84943592
103Deep philtrum (HP:0002002)1.82835708
104Cutis marmorata (HP:0000965)1.82774034
105Short thumb (HP:0009778)1.82575422
106Median cleft lip (HP:0000161)1.82509283
107Microglossia (HP:0000171)1.80608836
108Abnormality of the astrocytes (HP:0100707)1.80561459
109Astrocytoma (HP:0009592)1.80561459
110Hip dysplasia (HP:0001385)1.79646147
111Absent frontal sinuses (HP:0002688)1.78754219
112Inappropriate behavior (HP:0000719)1.77623847
113Supernumerary spleens (HP:0009799)1.77251140
114Neoplasm of the pancreas (HP:0002894)1.76727006
115Broad-based gait (HP:0002136)1.76428474
116Fair hair (HP:0002286)1.76083776
117Basal cell carcinoma (HP:0002671)1.75814729
118Heterotopia (HP:0002282)1.75418140
119Bone marrow hypocellularity (HP:0005528)1.75007112
120Horizontal nystagmus (HP:0000666)1.74969417
121Limb hypertonia (HP:0002509)1.74378488
122Aplasia/Hypoplasia of the tongue (HP:0010295)1.74054615
123Abnormality of the duodenum (HP:0002246)1.73887694
124Gastrointestinal carcinoma (HP:0002672)1.73860056
125Malignant gastrointestinal tract tumors (HP:0006749)1.73860056
126Lip pit (HP:0100267)1.73711524
127Abnormality of vitamin B metabolism (HP:0004340)1.73432379
128Drooling (HP:0002307)1.72926598
129Hyperglycinemia (HP:0002154)1.72252013
130Transitional cell carcinoma of the bladder (HP:0006740)1.72177279
131Abnormal lung lobation (HP:0002101)1.71506416
132Oral leukoplakia (HP:0002745)1.71294282
133Shoulder girdle muscle weakness (HP:0003547)1.71146305
134Absent speech (HP:0001344)1.70838386
135Amaurosis fugax (HP:0100576)1.70392135
136Postaxial foot polydactyly (HP:0001830)1.70093861
137Breast aplasia (HP:0100783)1.70086426
138Neoplasm of the small intestine (HP:0100833)1.69616135
139Breast carcinoma (HP:0003002)1.69554244
140Neoplasm of striated muscle (HP:0009728)1.69552407
141Poor coordination (HP:0002370)1.69500533
142Preaxial hand polydactyly (HP:0001177)1.68695305
143Abnormality of male internal genitalia (HP:0000022)1.68688141
144Abnormality of lateral ventricle (HP:0030047)1.66838358
145Squamous cell carcinoma (HP:0002860)1.66179475
146Subacute progressive viral hepatitis (HP:0006572)1.66006582
147Abnormal biliary tract morphology (HP:0012440)1.65635839
148Hypoplastic labia majora (HP:0000059)1.65233918
149Anencephaly (HP:0002323)1.64414700
150Posterior subcapsular cataract (HP:0007787)1.63983443
151Postaxial hand polydactyly (HP:0001162)1.63479730
152Atresia of the external auditory canal (HP:0000413)1.63368916
153Arteriovenous malformation (HP:0100026)1.63213741
154Sparse lateral eyebrow (HP:0005338)1.62758985
155Thyroiditis (HP:0100646)1.62533361
156Dynein arm defect of respiratory motile cilia (HP:0012255)1.62099389
157Absent/shortened dynein arms (HP:0200106)1.62099389
158Narrow forehead (HP:0000341)1.60604994
159Abnormality of the vitamin B12 metabolism (HP:0004341)1.60526091
160Hyperinsulinemic hypoglycemia (HP:0000825)1.60109127
161Lissencephaly (HP:0001339)1.59159149
162Abolished electroretinogram (ERG) (HP:0000550)1.58418993
163Atonic seizures (HP:0010819)1.57803841
164Excessive salivation (HP:0003781)1.57184840
165Cupped ear (HP:0000378)1.57080004
166Hypothermia (HP:0002045)1.57018511
167Male pseudohermaphroditism (HP:0000037)1.56585716
168Abnormal glycosylation (HP:0012345)1.56388938
169Abnormal protein N-linked glycosylation (HP:0012347)1.56388938

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.64301859
2LATS13.86869812
3NEK23.29256143
4TRIM283.27179964
5ACVR1B2.97277259
6STK38L2.94131653
7BRSK22.89631016
8LATS22.83209350
9TNIK2.74473524
10CDK122.71953212
11WNK32.67635846
12MST42.64443411
13PLK42.63774184
14WEE12.54993358
15SRPK12.45786496
16BCR2.31585649
17STK32.29563049
18PNCK2.23950623
19CASK1.98467950
20EIF2AK11.97576022
21TTK1.97217033
22MAP4K21.92331339
23PLK11.88933915
24CHEK21.87744907
25DYRK31.85002621
26PLK31.84511417
27MAP3K61.60663721
28MKNK21.60122439
29RPS6KA41.58592919
30BUB11.57789318
31AURKB1.57595162
32MELK1.52571482
33MAPK131.52481511
34MKNK11.50775089
35FRK1.48311395
36BRSK11.47804667
37CHEK11.47299346
38ATR1.39035238
39STK101.31256822
40OXSR11.26261901
41EEF2K1.23976281
42CDK41.23457711
43NEK11.22913281
44PINK11.22566743
45JAK31.22026892
46ATM1.22001290
47BMPR1B1.21318621
48PBK1.18897033
49EPHA41.18784636
50CDK91.16540284
51SIK31.15352874
52CDK81.12255386
53PDK21.10401937
54VRK11.06285324
55FGFR31.01979200
56CDK70.96434701
57CDK190.93177534
58PAK30.91619626
59NUAK10.91294610
60PDK40.91184456
61PDK30.91184456
62NEK60.90502199
63CDK60.89828712
64CCNB10.89704510
65CDK20.88694277
66GRK10.87718393
67NEK90.85853066
68TSSK60.83110500
69PIM10.82567674
70ERBB40.82528296
71MARK30.82320121
72STK390.82138335
73RPS6KB20.81545866
74STK40.81041195
75RAF10.79402989
76STK240.78928462
77KSR10.78716992
78CHUK0.78148294
79MAP3K80.77316923
80CSNK1G30.77076899
81MINK10.76228070
82CDK10.74836094
83CDK30.73506731
84TAOK30.71752001
85TAOK10.70689986
86EIF2AK30.70391977
87TGFBR10.70296373
88MAP4K10.69771514
89MAP2K70.68697656
90PASK0.66132413
91PRKCE0.65742526
92BMPR20.62754319
93PRKD30.62309236
94EIF2AK20.60354564
95CSNK1A1L0.60291944
96MAP3K40.60060309
97DYRK20.59916016
98MARK10.58633098
99MAP3K50.58058648
100DYRK1A0.57454656
101TXK0.57020809
102TYRO30.56386889
103EPHA30.55997179
104SGK20.55673976
105FER0.55237733
106IKBKE0.54952110
107ADRBK20.54022378
108BRD40.54021286
109ALK0.51995672
110FGR0.49187737
111EGFR0.49064582
112STK380.48787582
113ERBB30.48759115
114KSR20.48290224
115AURKA0.47112695
116YES10.46764367
117PRKAA10.45562279
118CSNK1G10.45204535
119INSRR0.44211748
120MAPK140.43778002
121PDGFRB0.42050872
122TEC0.40695474
123CSNK1E0.40502236
124MAPK100.39506704
125IRAK10.39427496
126AKT30.39243893
127PRKCG0.38912839
128MAP2K40.38768761
129RPS6KB10.38739105
130SCYL20.36651213
131SGK30.34259830
132NTRK20.32335785
133PRKCI0.30882814
134RPS6KA50.30836912
135PKN10.30757283
136BRAF0.30608064
137CSNK1D0.30386922
138CSNK1G20.30357556
139NLK0.30009556
140TAF10.29954368
141FGFR20.29750325
142TYK20.29241853
143AKT10.29188723
144MTOR0.28758749
145ZAK0.28606915
146PLK20.28299411
147MET0.27636806
148GSK3B0.27292219
149PRKACB0.27254938

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.55613924
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.49264119
3RNA transport_Homo sapiens_hsa030133.03247097
4Basal transcription factors_Homo sapiens_hsa030222.92539411
5Protein export_Homo sapiens_hsa030602.88429922
6Mismatch repair_Homo sapiens_hsa034302.51557839
7DNA replication_Homo sapiens_hsa030302.49357092
8Propanoate metabolism_Homo sapiens_hsa006402.46456270
9RNA degradation_Homo sapiens_hsa030182.45904161
10Fanconi anemia pathway_Homo sapiens_hsa034602.38918360
11RNA polymerase_Homo sapiens_hsa030202.37377499
12mRNA surveillance pathway_Homo sapiens_hsa030152.34589222
13Spliceosome_Homo sapiens_hsa030402.33537380
14Homologous recombination_Homo sapiens_hsa034402.30861135
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.25626827
16p53 signaling pathway_Homo sapiens_hsa041152.08945088
17Phototransduction_Homo sapiens_hsa047442.00974255
18Nucleotide excision repair_Homo sapiens_hsa034201.88737542
19Non-homologous end-joining_Homo sapiens_hsa034501.88285007
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.83389272
21Oocyte meiosis_Homo sapiens_hsa041141.82748890
22Base excision repair_Homo sapiens_hsa034101.80065227
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.77404246
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63642581
25Herpes simplex infection_Homo sapiens_hsa051681.60724001
26Regulation of autophagy_Homo sapiens_hsa041401.52319872
27Nicotine addiction_Homo sapiens_hsa050331.50714962
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46899335
29Butanoate metabolism_Homo sapiens_hsa006501.43434888
30Steroid biosynthesis_Homo sapiens_hsa001001.42291872
31Epstein-Barr virus infection_Homo sapiens_hsa051691.41581496
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40903603
33MicroRNAs in cancer_Homo sapiens_hsa052061.38531173
34Fatty acid elongation_Homo sapiens_hsa000621.38223024
35Proteasome_Homo sapiens_hsa030501.32714566
36Pancreatic cancer_Homo sapiens_hsa052121.29854825
37TGF-beta signaling pathway_Homo sapiens_hsa043501.29665382
38Viral carcinogenesis_Homo sapiens_hsa052031.28928311
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26002544
40Vitamin B6 metabolism_Homo sapiens_hsa007501.25412794
41Ether lipid metabolism_Homo sapiens_hsa005651.24680190
42Circadian rhythm_Homo sapiens_hsa047101.23881797
43Antigen processing and presentation_Homo sapiens_hsa046121.23420212
44Pyrimidine metabolism_Homo sapiens_hsa002401.21061015
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17758064
46Colorectal cancer_Homo sapiens_hsa052101.17012890
47Caffeine metabolism_Homo sapiens_hsa002321.15263196
48HTLV-I infection_Homo sapiens_hsa051661.10222225
49mTOR signaling pathway_Homo sapiens_hsa041501.09594331
50Small cell lung cancer_Homo sapiens_hsa052221.05427713
51Hepatitis B_Homo sapiens_hsa051611.05247253
52Nitrogen metabolism_Homo sapiens_hsa009101.02649608
53Measles_Homo sapiens_hsa051620.99570743
54Chronic myeloid leukemia_Homo sapiens_hsa052200.99517501
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.99474539
56Prolactin signaling pathway_Homo sapiens_hsa049170.98900852
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98292822
58Influenza A_Homo sapiens_hsa051640.98108209
59FoxO signaling pathway_Homo sapiens_hsa040680.97769917
60Primary immunodeficiency_Homo sapiens_hsa053400.93720723
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92991221
62One carbon pool by folate_Homo sapiens_hsa006700.92943670
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.92917081
64Linoleic acid metabolism_Homo sapiens_hsa005910.91278473
65Thyroid cancer_Homo sapiens_hsa052160.91260664
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89688947
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83050037
68Non-small cell lung cancer_Homo sapiens_hsa052230.82618322
69Prostate cancer_Homo sapiens_hsa052150.82542615
70Purine metabolism_Homo sapiens_hsa002300.82456992
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82176808
72Olfactory transduction_Homo sapiens_hsa047400.81462200
73Endometrial cancer_Homo sapiens_hsa052130.80249274
74Systemic lupus erythematosus_Homo sapiens_hsa053220.80077630
75T cell receptor signaling pathway_Homo sapiens_hsa046600.79303555
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78892711
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76907843
78Peroxisome_Homo sapiens_hsa041460.76559535
79Adherens junction_Homo sapiens_hsa045200.75813850
80Collecting duct acid secretion_Homo sapiens_hsa049660.75202440
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74147498
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.73947728
83Taste transduction_Homo sapiens_hsa047420.73146921
84Dorso-ventral axis formation_Homo sapiens_hsa043200.72644122
85Long-term depression_Homo sapiens_hsa047300.72322366
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72208654
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71200052
88Hippo signaling pathway_Homo sapiens_hsa043900.70949952
89Tryptophan metabolism_Homo sapiens_hsa003800.70948181
90Pentose phosphate pathway_Homo sapiens_hsa000300.69756004
91Dopaminergic synapse_Homo sapiens_hsa047280.69696086
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68633357
93Shigellosis_Homo sapiens_hsa051310.68237899
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.65492406
95beta-Alanine metabolism_Homo sapiens_hsa004100.65257292
96Renal cell carcinoma_Homo sapiens_hsa052110.64649831
97Toxoplasmosis_Homo sapiens_hsa051450.64456275
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64402956
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.63199077
100Viral myocarditis_Homo sapiens_hsa054160.62942443
101TNF signaling pathway_Homo sapiens_hsa046680.61690300
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59406143
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59366910
104Amphetamine addiction_Homo sapiens_hsa050310.57931297
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57386060
106Folate biosynthesis_Homo sapiens_hsa007900.55887824
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55150151
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55017314
109B cell receptor signaling pathway_Homo sapiens_hsa046620.53730899
110Apoptosis_Homo sapiens_hsa042100.53638532
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52178660
112Legionellosis_Homo sapiens_hsa051340.51364014
113Pathways in cancer_Homo sapiens_hsa052000.50071615
114Serotonergic synapse_Homo sapiens_hsa047260.50011951
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49883443
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48029800
117Choline metabolism in cancer_Homo sapiens_hsa052310.46501789
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45271959
119Inositol phosphate metabolism_Homo sapiens_hsa005620.45021609
120Acute myeloid leukemia_Homo sapiens_hsa052210.44961784
121HIF-1 signaling pathway_Homo sapiens_hsa040660.44776920
122Alcoholism_Homo sapiens_hsa050340.43461331
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.43274564
124VEGF signaling pathway_Homo sapiens_hsa043700.43201332
125Leishmaniasis_Homo sapiens_hsa051400.43181016
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42730422
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.42674448
128GABAergic synapse_Homo sapiens_hsa047270.41702390
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41520881
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41221463
131Platelet activation_Homo sapiens_hsa046110.41113126
132MAPK signaling pathway_Homo sapiens_hsa040100.40567178
133Glutamatergic synapse_Homo sapiens_hsa047240.40531089
134Glioma_Homo sapiens_hsa052140.40258708
135Osteoclast differentiation_Homo sapiens_hsa043800.40088267
136Lysine degradation_Homo sapiens_hsa003100.39888259
137Chemokine signaling pathway_Homo sapiens_hsa040620.39293565
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38840549
139Selenocompound metabolism_Homo sapiens_hsa004500.38803482
140Notch signaling pathway_Homo sapiens_hsa043300.38271819
141Sphingolipid metabolism_Homo sapiens_hsa006000.37487687
142Proteoglycans in cancer_Homo sapiens_hsa052050.37133241
143Allograft rejection_Homo sapiens_hsa053300.36700920
144Type I diabetes mellitus_Homo sapiens_hsa049400.36426671
145Morphine addiction_Homo sapiens_hsa050320.36373744
146Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35971708
147Wnt signaling pathway_Homo sapiens_hsa043100.35549692
148Hematopoietic cell lineage_Homo sapiens_hsa046400.34993467
149Circadian entrainment_Homo sapiens_hsa047130.34002509
150Asthma_Homo sapiens_hsa053100.31609364
151Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31351828
152Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30163559
153Fatty acid metabolism_Homo sapiens_hsa012120.29312338
154Hedgehog signaling pathway_Homo sapiens_hsa043400.27119165
155ABC transporters_Homo sapiens_hsa020100.26161076
156Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24063411
157Metabolic pathways_Homo sapiens_hsa011000.18552464
158Parkinsons disease_Homo sapiens_hsa050120.18305144

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