GPBP1L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)3.54887693
2negative regulation of erythrocyte differentiation (GO:0045647)3.52727525
3positive regulation of gamma-delta T cell activation (GO:0046645)3.42146172
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.40753441
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.30435557
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.30435557
7nuclear pore organization (GO:0006999)3.18966690
8antigen processing and presentation of endogenous antigen (GO:0019883)3.13674423
9regulation of gamma-delta T cell differentiation (GO:0045586)3.09274482
10hepatocyte apoptotic process (GO:0097284)3.07086224
11regulation of histone H3-K27 methylation (GO:0061085)3.03792457
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.01499922
13negative regulation of cell killing (GO:0031342)3.01499922
14regulation of nucleobase-containing compound transport (GO:0032239)3.00362135
15pore complex assembly (GO:0046931)2.94207693
16embryonic process involved in female pregnancy (GO:0060136)2.90048362
17neutrophil activation involved in immune response (GO:0002283)2.89149145
18regulation of gamma-delta T cell activation (GO:0046643)2.87398828
19detection of other organism (GO:0098543)2.85244675
20detection of bacterium (GO:0016045)2.74629701
21hypotonic response (GO:0006971)2.72969388
22pre-miRNA processing (GO:0031054)2.67893215
23regulation of B cell receptor signaling pathway (GO:0050855)2.66428261
24regulation of protein polyubiquitination (GO:1902914)2.64839734
25valine metabolic process (GO:0006573)2.64656547
26histone lysine demethylation (GO:0070076)2.60263988
27histone H3-K36 demethylation (GO:0070544)2.57345432
28negative regulation of DNA repair (GO:0045738)2.56705691
29cytoplasmic mRNA processing body assembly (GO:0033962)2.55868914
30histone H3-K9 demethylation (GO:0033169)2.54706209
313-UTR-mediated mRNA stabilization (GO:0070935)2.54387939
32cellular hyperosmotic response (GO:0071474)2.53719296
33regulation of histone H3-K9 methylation (GO:0051570)2.51625315
34B cell receptor signaling pathway (GO:0050853)2.50456641
35regulation of necroptotic process (GO:0060544)2.49941579
36phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.49180614
37histone demethylation (GO:0016577)2.48437948
38modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.48019107
39positive regulation by organism of defense response of other organism involved in symbiotic interact2.48019107
40modulation by symbiont of host immune response (GO:0052553)2.48019107
41positive regulation by symbiont of host defense response (GO:0052509)2.48019107
42modulation by symbiont of host defense response (GO:0052031)2.48019107
43modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.48019107
44bundle of His cell to Purkinje myocyte communication (GO:0086069)2.44864066
45COPII vesicle coating (GO:0048208)2.44837170
46cellular extravasation (GO:0045123)2.44680057
47positive regulation of granulocyte differentiation (GO:0030854)2.42159751
48positive regulation of protein import into nucleus, translocation (GO:0033160)2.40605631
49negative T cell selection (GO:0043383)2.40428077
50growth hormone receptor signaling pathway (GO:0060396)2.38510182
51urea metabolic process (GO:0019627)2.38231091
52urea cycle (GO:0000050)2.38231091
53desmosome organization (GO:0002934)2.36139853
54response to peptidoglycan (GO:0032494)2.35972137
55megakaryocyte development (GO:0035855)2.34684333
56positive thymic T cell selection (GO:0045059)2.34323142
57mRNA modification (GO:0016556)2.33548250
58detection of external biotic stimulus (GO:0098581)2.32331909
59production of molecular mediator involved in inflammatory response (GO:0002532)2.32306315
60regulation of transforming growth factor beta2 production (GO:0032909)2.32293788
61positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.31718341
62positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.31718341
63positive regulation of mitotic sister chromatid separation (GO:1901970)2.31718341
64embryonic placenta development (GO:0001892)2.31622274
65response to muramyl dipeptide (GO:0032495)2.30357286
66negative thymic T cell selection (GO:0045060)2.29383229
67poly(A)+ mRNA export from nucleus (GO:0016973)2.28909273
68phospholipid homeostasis (GO:0055091)2.26331554
69nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.24793748
70germinal center formation (GO:0002467)2.23503081
71negative regulation of fatty acid biosynthetic process (GO:0045717)2.23075182
72mitotic sister chromatid cohesion (GO:0007064)2.22553346
73pinocytosis (GO:0006907)2.21608790
74negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.21265688
75mitotic chromosome condensation (GO:0007076)2.20142787
76cellular response to zinc ion (GO:0071294)2.20063345
77cellular response to ethanol (GO:0071361)2.19971637
78regulation of RNA export from nucleus (GO:0046831)2.19054601
79protein demethylation (GO:0006482)2.18489818
80protein dealkylation (GO:0008214)2.18489818
81response to interleukin-15 (GO:0070672)2.17780662
82positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.17684550
83definitive hemopoiesis (GO:0060216)2.16868211
84positive regulation of histone deacetylation (GO:0031065)2.16555449
85regulation of posttranscriptional gene silencing (GO:0060147)2.16071626
86regulation of gene silencing by miRNA (GO:0060964)2.16071626
87regulation of gene silencing by RNA (GO:0060966)2.16071626
88positive regulation of B cell differentiation (GO:0045579)2.14549738
89regulation of chromatin binding (GO:0035561)2.14409429
90cellular glucuronidation (GO:0052695)2.13896469
91negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.13288279
92negative regulation of T-helper cell differentiation (GO:0045623)2.13288279
93regulation of interleukin-12 biosynthetic process (GO:0045075)2.12477700
94regulation of response to interferon-gamma (GO:0060330)2.12115579
95epithelial cell differentiation involved in prostate gland development (GO:0060742)2.11857261
96positive regulation of interferon-alpha production (GO:0032727)2.11458078
97cytokine secretion (GO:0050663)2.11455806
98cellular response to thyroid hormone stimulus (GO:0097067)2.11315923
99fatty acid transmembrane transport (GO:1902001)2.10918164
100regulation of chromatin silencing (GO:0031935)2.10418934
101regulation of histone methylation (GO:0031060)2.10332020
102fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.08733336
103negative regulation of B cell proliferation (GO:0030889)2.08607959
104detection of molecule of bacterial origin (GO:0032490)2.08471183
105peptidyl-threonine modification (GO:0018210)2.07780739
106positive regulation of Cdc42 GTPase activity (GO:0043089)2.07526353
107necroptotic process (GO:0070266)2.07207853
108regulation of cholesterol homeostasis (GO:2000188)2.06997855
109cysteine metabolic process (GO:0006534)2.06872078
110negative regulation of histone methylation (GO:0031061)2.06768724
111regulation of fibroblast apoptotic process (GO:2000269)2.06755636
112macrophage activation involved in immune response (GO:0002281)2.06500807
113negative regulation of protein localization to plasma membrane (GO:1903077)2.06200644
114negative regulation of myotube differentiation (GO:0010832)2.06059636
115negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.05827477
116JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.05712251
117regulation of cholesterol storage (GO:0010885)2.05539203
118chromatin assembly (GO:0031497)2.05150382
119iron ion import (GO:0097286)2.04920947
120positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.04755722
121regulation of triglyceride catabolic process (GO:0010896)2.04409099
122tryptophan metabolic process (GO:0006568)2.04311607
123regulation of interferon-beta biosynthetic process (GO:0045357)2.04223235
124thymic T cell selection (GO:0045061)2.04151696
125positive regulation of cellular amide metabolic process (GO:0034250)2.04094404
126negative regulation of T cell mediated immunity (GO:0002710)2.03924823
127natural killer cell differentiation (GO:0001779)2.03604082
128regulation of mRNA stability (GO:0043488)2.03447427
129phospholipid efflux (GO:0033700)2.03372048
130nitrogen cycle metabolic process (GO:0071941)2.03254019
131cellular response to growth hormone stimulus (GO:0071378)2.02763036
132peptidyl-threonine phosphorylation (GO:0018107)2.02689688
133homocysteine metabolic process (GO:0050667)2.02411225
134necrotic cell death (GO:0070265)2.02361692
135sulfur amino acid catabolic process (GO:0000098)2.02170352
136regulation of B cell differentiation (GO:0045577)2.00578270
137dosage compensation (GO:0007549)2.00535606
138regulation of superoxide anion generation (GO:0032928)2.00353510
139trophectodermal cell differentiation (GO:0001829)2.00180369
140intestinal epithelial cell development (GO:0060576)2.00094249
141regulation of interferon-alpha production (GO:0032647)2.00017909
142serine family amino acid catabolic process (GO:0009071)1.99610928
143T cell selection (GO:0045058)1.99463905
144hormone catabolic process (GO:0042447)1.98427125
145RNA stabilization (GO:0043489)1.97324705
146mRNA stabilization (GO:0048255)1.97324705
147regulation of gene silencing (GO:0060968)1.97173841
148positive regulation of natural killer cell differentiation (GO:0032825)1.97152102
149carnitine shuttle (GO:0006853)1.96742615
150indole-containing compound catabolic process (GO:0042436)1.96173270
151indolalkylamine catabolic process (GO:0046218)1.96173270
152tryptophan catabolic process (GO:0006569)1.96173270
153regulation of interferon-gamma-mediated signaling pathway (GO:0060334)1.94928540
154meiotic chromosome segregation (GO:0045132)1.94821938
155negative regulation of retinoic acid receptor signaling pathway (GO:0048387)1.93558416
156histone mRNA catabolic process (GO:0071044)1.93432674
157response to UV-C (GO:0010225)1.93373366
158positive regulation of interferon-beta production (GO:0032728)1.93137807
159negative regulation of lipid storage (GO:0010888)1.92992680
160positive regulation of fatty acid beta-oxidation (GO:0032000)1.92552165
161intracellular lipid transport (GO:0032365)1.92128246
162dendritic cell chemotaxis (GO:0002407)1.92073519
163response to nitrosative stress (GO:0051409)1.91745678
164monoubiquitinated protein deubiquitination (GO:0035520)1.89752964
165protein K6-linked ubiquitination (GO:0085020)1.89465732
166dendritic cell migration (GO:0036336)1.88415913
167plasma lipoprotein particle assembly (GO:0034377)1.87871134

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.22997008
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.56121854
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.11272139
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.08071425
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.03390850
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.70232394
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.63012826
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.61717643
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.54194620
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.48639857
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.47852789
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.45956486
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.32320656
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.31454994
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.23906549
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.17717891
17LXR_22158963_ChIP-Seq_LIVER_Mouse2.07239118
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.01366336
19TP63_17297297_ChIP-ChIP_HaCaT_Human1.89960446
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87632237
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87122566
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.77518708
23GATA1_22025678_ChIP-Seq_K562_Human1.74167456
24* MYB_26560356_Chip-Seq_TH2_Human1.70928878
25MYC_22102868_ChIP-Seq_BL_Human1.69661611
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.68999899
27* MYB_26560356_Chip-Seq_TH1_Human1.67764674
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65709265
29RUNX_20019798_ChIP-Seq_JUKART_Human1.64341291
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.63828143
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62982735
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59452817
33SALL4_18804426_ChIP-ChIP_XEN_Mouse1.58677102
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.58130017
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57302575
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.55882342
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51475033
38* MAF_26560356_Chip-Seq_TH1_Human1.51166692
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.50955433
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.49878220
41SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.49336499
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49053137
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47866626
44CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.46572891
45* CHD1_26751641_Chip-Seq_LNCaP_Human1.43877195
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.42832408
47GATA1_19941826_ChIP-Seq_K562_Human1.41759413
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41310025
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38810705
50CLOCK_20551151_ChIP-Seq_293T_Human1.35678413
51SCL_19346495_ChIP-Seq_HPC-7_Human1.35603444
52GATA2_19941826_ChIP-Seq_K562_Human1.35519200
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32962263
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32962263
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32962263
56TCF7_22412390_ChIP-Seq_EML_Mouse1.29750491
57UTX_26944678_Chip-Seq_JUKART_Human1.29652133
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29045672
59FOXO3_23340844_ChIP-Seq_DLD1_Human1.27136938
60SPI1_23127762_ChIP-Seq_K562_Human1.26938988
61* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.26762099
62* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23790557
63* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23370983
64GATA6_25053715_ChIP-Seq_YYC3_Human1.23349063
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.22823296
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21988511
67SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21254023
68SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20233058
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.19630567
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18954167
71RUNX1_22412390_ChIP-Seq_EML_Mouse1.18403524
72TFEB_21752829_ChIP-Seq_HELA_Human1.15889333
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12478163
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11501232
75* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.11315863
76* SPI1_23547873_ChIP-Seq_NB4_Human1.11234446
77PU_27001747_Chip-Seq_BMDM_Mouse1.09966911
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09361198
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.08395903
80* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08326562
81VDR_21846776_ChIP-Seq_THP-1_Human1.07817879
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07117681
83GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06917150
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.05358222
85AR_21909140_ChIP-Seq_LNCAP_Human1.04723817
86SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04523336
87SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04523336
88E2F1_21310950_ChIP-Seq_MCF-7_Human1.04254417
89GATA3_27048872_Chip-Seq_THYMUS_Human1.03277950
90FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03263231
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02861615
92* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02668667
93SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01453306
94PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00759448
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98019143
96GATA4_25053715_ChIP-Seq_YYC3_Human0.97390957
97VDR_24787735_ChIP-Seq_THP-1_Human0.96357898
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95717981
99TCF4_18268006_ChIP-ChIP_LS174T_Human0.94611607
100PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94551691
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93717181
102HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91477410
103TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91337532
104CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90840619
105FOXA2_19822575_ChIP-Seq_HepG2_Human0.89458612
106* NCOR1_26117541_ChIP-Seq_K562_Human0.88901760
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88646334
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88577366
109* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88563152
110ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87612841
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87595266
112VDR_24763502_ChIP-Seq_THP-1_Human0.87127257
113ESR1_21235772_ChIP-Seq_MCF-7_Human0.86824743
114FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.86657614
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86028654
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85730150
117NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82331877
118HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82178617
119BP1_19119308_ChIP-ChIP_Hs578T_Human0.81912391
120E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.81731607
121ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81622550
122TCF3_18692474_ChIP-Seq_MESCs_Mouse0.81230248
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81062193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system2.36324875
2MP0005360_urolithiasis2.34793270
3MP0010234_abnormal_vibrissa_follicle2.21677902
4MP0002166_altered_tumor_susceptibility2.19810179
5MP0005451_abnormal_body_composition2.19566089
6MP0001835_abnormal_antigen_presentation2.19224185
7MP0005085_abnormal_gallbladder_physiolo1.97198508
8MP0005365_abnormal_bile_salt1.95425791
9MP0010352_gastrointestinal_tract_polyps1.92821996
10MP0003300_gastrointestinal_ulcer1.82604362
11MP0002006_tumorigenesis1.82473756
12MP0002009_preneoplasia1.82102292
13MP0003252_abnormal_bile_duct1.81891627
14MP0003656_abnormal_erythrocyte_physiolo1.77657660
15MP0004264_abnormal_extraembryonic_tissu1.71105446
16MP0003763_abnormal_thymus_physiology1.68581323
17MP0000685_abnormal_immune_system1.68136744
18MP0001800_abnormal_humoral_immune1.65412248
19MP0003705_abnormal_hypodermis_morpholog1.65388720
20MP0003191_abnormal_cellular_cholesterol1.60730758
21MP0010155_abnormal_intestine_physiology1.58900112
22MP0002877_abnormal_melanocyte_morpholog1.58259964
23MP0002254_reproductive_system_inflammat1.57796031
24MP0010307_abnormal_tumor_latency1.55775739
25MP0004957_abnormal_blastocyst_morpholog1.55516874
26MP0003183_abnormal_peptide_metabolism1.53606435
27MP0001790_abnormal_immune_system1.47927745
28MP0005387_immune_system_phenotype1.47927745
29MP0003436_decreased_susceptibility_to1.47232427
30MP0005671_abnormal_response_to1.46810850
31MP0005076_abnormal_cell_differentiation1.43019709
32MP0008057_abnormal_DNA_replication1.41425413
33MP0002396_abnormal_hematopoietic_system1.39210535
34MP0002452_abnormal_antigen_presenting1.38356074
35MP0008875_abnormal_xenobiotic_pharmacok1.35028626
36MP0003806_abnormal_nucleotide_metabolis1.33181639
37MP0006054_spinal_hemorrhage1.29645207
38MP0003453_abnormal_keratinocyte_physiol1.29533124
39MP0004947_skin_inflammation1.29481067
40MP0002138_abnormal_hepatobiliary_system1.29028164
41MP0002723_abnormal_immune_serum1.27805849
42MP0000609_abnormal_liver_physiology1.26350891
43MP0009785_altered_susceptibility_to1.25320974
44MP0005000_abnormal_immune_tolerance1.24248470
45MP0005025_abnormal_response_to1.23977792
46MP0005409_darkened_coat_color1.23592782
47MP0001851_eye_inflammation1.23580130
48MP0001873_stomach_inflammation1.22472536
49MP0002420_abnormal_adaptive_immunity1.22237089
50MP0001730_embryonic_growth_arrest1.22235009
51MP0002398_abnormal_bone_marrow1.22145236
52MP0001819_abnormal_immune_cell1.21702182
53MP0004808_abnormal_hematopoietic_stem1.20244023
54MP0008260_abnormal_autophagy1.18019214
55MP0006082_CNS_inflammation1.17294717
56MP0008007_abnormal_cellular_replicative1.15596882
57MP0002405_respiratory_system_inflammati1.14414749
58MP0003566_abnormal_cell_adhesion1.13547094
59MP0003724_increased_susceptibility_to1.12003074
60MP0003693_abnormal_embryo_hatching1.11078459
61MP0003303_peritoneal_inflammation1.10399629
62MP0010094_abnormal_chromosome_stability1.10120227
63MP0010329_abnormal_lipoprotein_level1.10093151
64MP0003941_abnormal_skin_development1.09927114
65MP0000716_abnormal_immune_system1.09661430
66MP0003091_abnormal_cell_migration1.08819165
67MP0002419_abnormal_innate_immunity1.07970217
68MP0009053_abnormal_anal_canal1.07855540
69MP0003984_embryonic_growth_retardation1.06345020
70MP0002148_abnormal_hypersensitivity_rea1.06235538
71MP0001666_abnormal_nutrient_absorption1.05743608
72MP0005501_abnormal_skin_physiology1.05482580
73MP0001845_abnormal_inflammatory_respons1.05443896
74MP0000689_abnormal_spleen_morphology1.05320256
75MP0002722_abnormal_immune_system1.05084788
76MP0003866_abnormal_defecation1.03586957
77MP0005464_abnormal_platelet_physiology1.03170039
78MP0000490_abnormal_crypts_of1.03142786
79MP0001853_heart_inflammation1.03067369
80MP0002088_abnormal_embryonic_growth/wei1.02897464
81MP0004185_abnormal_adipocyte_glucose1.02509724
82MP0001545_abnormal_hematopoietic_system0.99530704
83MP0005397_hematopoietic_system_phenotyp0.99530704
84MP0009115_abnormal_fat_cell0.99490632
85MP0003077_abnormal_cell_cycle0.98830955
86MP0003221_abnormal_cardiomyocyte_apopto0.96511145
87MP0005310_abnormal_salivary_gland0.94154153
88MP0002429_abnormal_blood_cell0.93943964
89MP0005380_embryogenesis_phenotype0.93403909
90MP0001672_abnormal_embryogenesis/_devel0.93403909
91MP0009333_abnormal_splenocyte_physiolog0.93099090
92MP0009278_abnormal_bone_marrow0.92956781
93MP0005666_abnormal_adipose_tissue0.92876282
94MP0000465_gastrointestinal_hemorrhage0.91542375
95MP0000703_abnormal_thymus_morphology0.90573610
96MP0001216_abnormal_epidermal_layer0.87799145
97MP0009643_abnormal_urine_homeostasis0.87737524
98MP0002060_abnormal_skin_morphology0.87402754
99MP0005621_abnormal_cell_physiology0.87017668
100MP0002998_abnormal_bone_remodeling0.86983135
101MP0003448_altered_tumor_morphology0.85686376
102MP0002019_abnormal_tumor_incidence0.84127606
103MP0005023_abnormal_wound_healing0.83951569
104MP0002086_abnormal_extraembryonic_tissu0.83556088
105MP0005408_hypopigmentation0.82950036
106MP0009763_increased_sensitivity_to0.82637880
107MP0002136_abnormal_kidney_physiology0.82433785
108MP0000377_abnormal_hair_follicle0.81771229
109MP0008469_abnormal_protein_level0.81321716
110MP0010630_abnormal_cardiac_muscle0.81302381
111MP0002796_impaired_skin_barrier0.81176978
112MP0003868_abnormal_feces_composition0.81109428
113MP0003828_pulmonary_edema0.80864630
114MP0008995_early_reproductive_senescence0.80848464
115MP0000383_abnormal_hair_follicle0.80409064
116MP0003111_abnormal_nucleus_morphology0.78705423
117MP0001661_extended_life_span0.78105293
118MP0002132_abnormal_respiratory_system0.78092871
119MP0003186_abnormal_redox_activity0.77829666
120MP0000350_abnormal_cell_proliferation0.76383634
121MP0005647_abnormal_sex_gland0.75485881
122MP0000858_altered_metastatic_potential0.75070921
123MP0000598_abnormal_liver_morphology0.74497535
124MP0001915_intracranial_hemorrhage0.74167005
125MP0010678_abnormal_skin_adnexa0.73231412
126MP0005670_abnormal_white_adipose0.72583635
127MP0002098_abnormal_vibrissa_morphology0.72481452

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.56913926
2Papillary thyroid carcinoma (HP:0002895)3.30565812
3Flat acetabular roof (HP:0003180)2.88604599
4T lymphocytopenia (HP:0005403)2.80571708
5Myocardial infarction (HP:0001658)2.79135729
6Autoimmune thrombocytopenia (HP:0001973)2.77663347
7Abnormality of T cell number (HP:0011839)2.76115805
8Recurrent viral infections (HP:0004429)2.75683211
9Intrahepatic cholestasis (HP:0001406)2.71093218
10Curly hair (HP:0002212)2.69790248
11Hematochezia (HP:0002573)2.67426212
12Lip pit (HP:0100267)2.58455066
13Abnormality of monocarboxylic acid metabolism (HP:0010996)2.54853675
14Ankyloglossia (HP:0010296)2.53944970
15Eczematoid dermatitis (HP:0000976)2.53759104
16Pustule (HP:0200039)2.51563445
17Recurrent fungal infections (HP:0002841)2.48195044
18Malnutrition (HP:0004395)2.47275109
19Increased IgE level (HP:0003212)2.46832793
20Colitis (HP:0002583)2.43367084
21Chronic diarrhea (HP:0002028)2.37177777
22Progressive external ophthalmoplegia (HP:0000590)2.35448692
23Hypochromic microcytic anemia (HP:0004840)2.33367146
24Acanthocytosis (HP:0001927)2.33109507
25Hypoglycemic coma (HP:0001325)2.30555971
26Esophageal varix (HP:0002040)2.29710831
27Gastrointestinal infarctions (HP:0005244)2.25348636
28Thyroid carcinoma (HP:0002890)2.23228455
29Dysmetric saccades (HP:0000641)2.21089842
30Abnormality of macrophages (HP:0004311)2.20460723
31Abnormality of T cells (HP:0002843)2.19791354
32Recurrent abscess formation (HP:0002722)2.17530412
33Neonatal hypoglycemia (HP:0001998)2.16522481
34Abnormality of oral frenula (HP:0000190)2.13764555
35Gingivitis (HP:0000230)2.12158580
36Recurrent bronchitis (HP:0002837)2.12008330
37Abnormality of the left ventricular outflow tract (HP:0011103)2.11999712
38Subaortic stenosis (HP:0001682)2.11999712
39Abnormality of the nasal septum (HP:0000419)2.11440817
40Viral hepatitis (HP:0006562)2.10719328
41IgA deficiency (HP:0002720)2.10477670
42Recurrent bacterial skin infections (HP:0005406)2.09993570
43IgM deficiency (HP:0002850)2.09538890
44Autoimmune hemolytic anemia (HP:0001890)2.08900068
45Fatigue (HP:0012378)2.08336365
46Prolonged bleeding time (HP:0003010)2.08145422
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.07088738
48Abnormal platelet volume (HP:0011876)2.06627517
49Spontaneous hematomas (HP:0007420)2.04550893
50Recurrent gram-negative bacterial infections (HP:0005420)2.04077557
51Hyperglycinuria (HP:0003108)2.03522649
52Inflammation of the large intestine (HP:0002037)2.03252313
53Thickened calvaria (HP:0002684)2.00679611
54Biliary tract neoplasm (HP:0100574)1.99533997
55Chromsome breakage (HP:0040012)1.98644776
56Syringomyelia (HP:0003396)1.98109236
57Spinal cord lesions (HP:0100561)1.98109236
58Complement deficiency (HP:0004431)1.97925061
59Neoplasm of the tracheobronchial system (HP:0100552)1.97640203
60Arterial thrombosis (HP:0004420)1.96162722
61Vertebral arch anomaly (HP:0008438)1.95778374
62Prostate neoplasm (HP:0100787)1.94784245
63Abnormality of glutamine family amino acid metabolism (HP:0010902)1.94651645
64Recurrent skin infections (HP:0001581)1.94308488
65Joint hemorrhage (HP:0005261)1.94306572
66Combined immunodeficiency (HP:0005387)1.94017822
67Increased mean platelet volume (HP:0011877)1.93689418
68Abnormality of T cell physiology (HP:0011840)1.93582065
69Metaphyseal cupping (HP:0003021)1.93370291
70Thyroiditis (HP:0100646)1.91979013
71Right ventricular cardiomyopathy (HP:0011663)1.91570656
72Acute myeloid leukemia (HP:0004808)1.91484459
73Periodontitis (HP:0000704)1.91103814
74Poikilocytosis (HP:0004447)1.90256721
75Uterine leiomyosarcoma (HP:0002891)1.89804448
76Leiomyosarcoma (HP:0100243)1.89804448
77Abnormality of the salivary glands (HP:0010286)1.89279468
78Subacute progressive viral hepatitis (HP:0006572)1.88757707
79Gingival bleeding (HP:0000225)1.88711643
80Deep venous thrombosis (HP:0002625)1.88600776
81Hypoalphalipoproteinemia (HP:0003233)1.88265964
82Agammaglobulinemia (HP:0004432)1.87885157
83Volvulus (HP:0002580)1.87716430
84Cellulitis (HP:0100658)1.87709163
85Nephroblastoma (Wilms tumor) (HP:0002667)1.86604146
86Hypochromic anemia (HP:0001931)1.86252844
87Abnormality of the common coagulation pathway (HP:0010990)1.85957226
88Transitional cell carcinoma of the bladder (HP:0006740)1.85920342
89Abnormality of the vasculature of the conjunctiva (HP:0008054)1.85251672
90Neoplasm of the small intestine (HP:0100833)1.84077857
91Abnormality of the distal phalanges of the toes (HP:0010182)1.83878028
92Conjunctival telangiectasia (HP:0000524)1.81766854
93Gastrointestinal inflammation (HP:0004386)1.81360868
94Coarse hair (HP:0002208)1.80675810
95Myositis (HP:0100614)1.80436966
96Abnormality of pyrimidine metabolism (HP:0004353)1.80365461
97Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.79378458
98Abnormal biliary tract morphology (HP:0012440)1.79082969
99Epistaxis (HP:0000421)1.77954253
100Hypoplasia of the thymus (HP:0000778)1.77354490
101Osteolytic defects of the hand bones (HP:0009699)1.77302949
102Osteolytic defects of the phalanges of the hand (HP:0009771)1.77302949
103Abnormal foot bone ossification (HP:0010675)1.76885020
104Renal cortical cysts (HP:0000803)1.76303134
105Polycythemia (HP:0001901)1.75542002
106Epidermoid cyst (HP:0200040)1.75510411
107Urticaria (HP:0001025)1.75500775
108Bladder carcinoma (HP:0002862)1.75480984
109Bladder neoplasm (HP:0009725)1.75480984
110Alveolar cell carcinoma (HP:0006519)1.75236989
111Hypobetalipoproteinemia (HP:0003563)1.74973255
112Nasal polyposis (HP:0100582)1.73583372
113Xanthomatosis (HP:0000991)1.73226567
114Abnormality of sulfur amino acid metabolism (HP:0004339)1.73083298
115Hepatocellular carcinoma (HP:0001402)1.71444356
116Gastrointestinal carcinoma (HP:0002672)1.70344959
117Malignant gastrointestinal tract tumors (HP:0006749)1.70344959
118Fat malabsorption (HP:0002630)1.69795582
119Amaurosis fugax (HP:0100576)1.69778868
120Urethral obstruction (HP:0000796)1.68822490
121Uterine neoplasm (HP:0010784)1.68124820
122Segmental peripheral demyelination/remyelination (HP:0003481)1.67989093
123Rectal prolapse (HP:0002035)1.67223912
124Hypolipoproteinemia (HP:0010981)1.66201436
125Recurrent sinusitis (HP:0011108)1.65949852
126Vasculitis (HP:0002633)1.65220651
127Osteomyelitis (HP:0002754)1.64990643
128Meningitis (HP:0001287)1.64864651
129Rhabdomyosarcoma (HP:0002859)1.64771520
130Embryonal renal neoplasm (HP:0011794)1.64465970
131Severe combined immunodeficiency (HP:0004430)1.64448550
132Lower limb hyperreflexia (HP:0002395)1.64263530
133Abnormality of small intestinal villus morphology (HP:0011472)1.64160447
134Villous atrophy (HP:0011473)1.64160447
135Eosinophilia (HP:0001880)1.64141860
136Orchitis (HP:0100796)1.64114341
137Verrucae (HP:0200043)1.63546821
138Papilloma (HP:0012740)1.63546821
139Intestinal fistula (HP:0100819)1.63479890
140Nephritis (HP:0000123)1.63361653
141Hyperactive renin-angiotensin system (HP:0000841)1.63262023
142Pseudobulbar signs (HP:0002200)1.62279612
143Hyperkalemia (HP:0002153)1.61721723
144Cystic hygroma (HP:0000476)1.60083370
145Mediastinal lymphadenopathy (HP:0100721)1.58497151
146Chromosomal breakage induced by crosslinking agents (HP:0003221)1.58203356
147Deep philtrum (HP:0002002)1.58115394
148Short 1st metacarpal (HP:0010034)1.57963926
149Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.57963926
150Thrombocytosis (HP:0001894)1.57344478
151Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.57197073
152Lymphopenia (HP:0001888)1.57157544
153Hypercholesterolemia (HP:0003124)1.56839693
154Abnormality of the nasal mucosa (HP:0000433)1.56252889
155Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.56224693
156Abnormality of complement system (HP:0005339)1.55990232

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.67884345
2PRPF4B2.85790945
3RIPK42.57150492
4MAP3K142.28344861
5MAP4K12.27593412
6ACVR1B2.25335964
7FRK2.21861579
8MAP3K102.08049181
9TYK22.01457694
10LATS12.00055937
11MAP3K21.94830971
12STK101.90979748
13TXK1.84597726
14JAK31.78392100
15FGFR41.77325059
16FGFR31.76101427
17STK41.70106011
18MAP3K131.67970348
19PIM11.58318023
20MST41.53773309
21BRD41.51117330
22NEK91.49657282
23IKBKE1.46355605
24JAK11.43305597
25FLT31.43279852
26IRAK31.42958915
27SMG11.42777252
28ERN11.42594448
29EEF2K1.39910165
30PKN21.39057205
31KSR21.38031621
32CDK61.37112760
33IKBKB1.36126209
34CHUK1.33563378
35CSK1.31906579
36STK31.30770284
37PBK1.27640805
38TAOK31.26744368
39NLK1.21679005
40PTK61.21309153
41IRAK41.20757276
42NUAK11.19934270
43GRK61.19102164
44CDK91.19030390
45RPS6KB21.17394496
46INSRR1.17288847
47BRSK21.16890245
48NEK21.16562651
49EIF2AK31.15527984
50RIPK11.12640755
51WNK11.11473020
52TGFBR21.09782626
53ITK1.09265898
54FGR1.07407141
55MAP3K61.05246895
56CAMK1G1.03626672
57ZAK1.02243216
58MAP3K10.99699615
59PDK20.99138469
60CDK40.99095158
61EPHA20.98800877
62ZAP700.97657306
63SIK10.97036525
64TBK10.96653284
65TAF10.95596460
66EIF2AK10.94232739
67TRPM70.92298038
68PASK0.91975542
69SGK30.91950358
70CAMK1D0.89460592
71RPS6KA40.89197417
72LRRK20.85451569
73JAK20.84958609
74SCYL20.84869626
75RET0.83094342
76FGFR20.82739563
77CSF1R0.80567657
78AKT30.80330809
79MELK0.79246604
80TRIB30.78996045
81EPHB10.77719403
82KIT0.77356806
83BTK0.77120182
84TEC0.76476866
85PRKAA20.76402818
86MAP3K70.72932990
87ICK0.72840192
88SIK30.71442213
89MAP3K30.69579562
90LCK0.68912118
91MARK30.68672212
92MET0.68438167
93TTN0.68227932
94IRAK10.68178189
95EPHA30.68085729
96PDGFRB0.67928936
97MTOR0.66447485
98NEK60.66050386
99MST1R0.65832344
100BLK0.65223535
101MKNK10.63931603
102GSK3A0.63352522
103BMX0.61872597
104STK240.61527880
105RPS6KB10.60214804
106ATR0.59946994
107MAPK110.59466386
108MKNK20.59318408
109DMPK0.59159403
110MAP3K80.56871711
111PIK3CA0.56231140
112BCKDK0.55912830
113MAP2K30.55755775
114CDC70.55193556
115SGK20.55082933
116ATM0.54946577
117SRPK10.54877275
118HIPK20.54550019
119TTK0.54297612
120RAF10.53973041
121KSR10.53574032
122TGFBR10.53243527
123MATK0.52837668
124AURKB0.52230513
125CDK70.52100979
126HCK0.51769044
127TLK10.50569824
128PDGFRA0.50162356
129SYK0.50028246
130YES10.48579333
131MAPK150.48173569
132PIK3CG0.47761528
133FGFR10.46991834
134LYN0.46746528
135CHEK10.45976716
136BMPR20.44819490
137DYRK1B0.44575921

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.13070640
2Thyroid cancer_Homo sapiens_hsa052162.05118076
3NF-kappa B signaling pathway_Homo sapiens_hsa040641.88810659
4Pentose and glucuronate interconversions_Homo sapiens_hsa000401.88683071
5Nitrogen metabolism_Homo sapiens_hsa009101.82214236
6Primary immunodeficiency_Homo sapiens_hsa053401.81906960
7Non-small cell lung cancer_Homo sapiens_hsa052231.77815337
8Staphylococcus aureus infection_Homo sapiens_hsa051501.74607665
9Fatty acid degradation_Homo sapiens_hsa000711.74140031
10Selenocompound metabolism_Homo sapiens_hsa004501.68113650
11Primary bile acid biosynthesis_Homo sapiens_hsa001201.67518678
12Renal cell carcinoma_Homo sapiens_hsa052111.66370567
13Caffeine metabolism_Homo sapiens_hsa002321.65960649
14Lysine degradation_Homo sapiens_hsa003101.64995363
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.54401675
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.51325818
17Tryptophan metabolism_Homo sapiens_hsa003801.49192262
18Antigen processing and presentation_Homo sapiens_hsa046121.46331378
19Endometrial cancer_Homo sapiens_hsa052131.43824163
20Complement and coagulation cascades_Homo sapiens_hsa046101.41813445
21Measles_Homo sapiens_hsa051621.34903384
22Systemic lupus erythematosus_Homo sapiens_hsa053221.33124093
23PPAR signaling pathway_Homo sapiens_hsa033201.30242295
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29439356
25Herpes simplex infection_Homo sapiens_hsa051681.24042381
26One carbon pool by folate_Homo sapiens_hsa006701.24004142
27Leishmaniasis_Homo sapiens_hsa051401.20949053
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19746416
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19537268
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19441594
31ABC transporters_Homo sapiens_hsa020101.17780828
32Chemical carcinogenesis_Homo sapiens_hsa052041.17742625
33Arginine biosynthesis_Homo sapiens_hsa002201.15639310
34mTOR signaling pathway_Homo sapiens_hsa041501.14758769
35Other glycan degradation_Homo sapiens_hsa005111.14752945
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11216796
37Prolactin signaling pathway_Homo sapiens_hsa049171.10990993
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10591336
39Small cell lung cancer_Homo sapiens_hsa052221.07197431
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07085679
41Inositol phosphate metabolism_Homo sapiens_hsa005621.06780198
42Osteoclast differentiation_Homo sapiens_hsa043801.05498417
43Non-homologous end-joining_Homo sapiens_hsa034501.05449249
44B cell receptor signaling pathway_Homo sapiens_hsa046621.04360066
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.03271376
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.03049758
47Toxoplasmosis_Homo sapiens_hsa051451.02941725
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02089701
49Retinol metabolism_Homo sapiens_hsa008301.02019292
50Colorectal cancer_Homo sapiens_hsa052101.01280321
51Influenza A_Homo sapiens_hsa051641.01099475
52VEGF signaling pathway_Homo sapiens_hsa043701.00962105
53Propanoate metabolism_Homo sapiens_hsa006401.00554715
54Sulfur metabolism_Homo sapiens_hsa009200.98913380
55Hematopoietic cell lineage_Homo sapiens_hsa046400.97959667
56Starch and sucrose metabolism_Homo sapiens_hsa005000.97822121
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96756252
58Viral carcinogenesis_Homo sapiens_hsa052030.95413631
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95308149
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.94818797
61Histidine metabolism_Homo sapiens_hsa003400.93568488
62Choline metabolism in cancer_Homo sapiens_hsa052310.93371026
63Fatty acid metabolism_Homo sapiens_hsa012120.91832593
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91679158
65Chemokine signaling pathway_Homo sapiens_hsa040620.90980200
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90719729
67Insulin signaling pathway_Homo sapiens_hsa049100.90384688
68Legionellosis_Homo sapiens_hsa051340.90366954
69T cell receptor signaling pathway_Homo sapiens_hsa046600.89946406
70Dorso-ventral axis formation_Homo sapiens_hsa043200.89209726
71Adherens junction_Homo sapiens_hsa045200.88646587
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88633754
73Insulin resistance_Homo sapiens_hsa049310.88500968
74Peroxisome_Homo sapiens_hsa041460.87875435
75beta-Alanine metabolism_Homo sapiens_hsa004100.87540012
76Fat digestion and absorption_Homo sapiens_hsa049750.86892189
77HIF-1 signaling pathway_Homo sapiens_hsa040660.86665273
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86370574
79ErbB signaling pathway_Homo sapiens_hsa040120.86365012
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85025119
81Fatty acid biosynthesis_Homo sapiens_hsa000610.84837654
82Acute myeloid leukemia_Homo sapiens_hsa052210.84792221
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.84035810
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.83545258
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83298680
86TNF signaling pathway_Homo sapiens_hsa046680.82134022
87Apoptosis_Homo sapiens_hsa042100.80303487
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79933128
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78892430
90Vitamin digestion and absorption_Homo sapiens_hsa049770.77632877
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76786260
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.75871879
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74406923
94Notch signaling pathway_Homo sapiens_hsa043300.74158714
95Graft-versus-host disease_Homo sapiens_hsa053320.72575163
96p53 signaling pathway_Homo sapiens_hsa041150.71817814
97MicroRNAs in cancer_Homo sapiens_hsa052060.71400424
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.71074375
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69462175
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.68257251
101Phenylalanine metabolism_Homo sapiens_hsa003600.67511939
102Proteoglycans in cancer_Homo sapiens_hsa052050.66589154
103Fanconi anemia pathway_Homo sapiens_hsa034600.66365792
104Cell cycle_Homo sapiens_hsa041100.66167800
105Prostate cancer_Homo sapiens_hsa052150.66139049
106Chronic myeloid leukemia_Homo sapiens_hsa052200.65945578
107Amoebiasis_Homo sapiens_hsa051460.64938435
108Hepatitis C_Homo sapiens_hsa051600.64477427
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64246552
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64128338
111Allograft rejection_Homo sapiens_hsa053300.63264452
112Bladder cancer_Homo sapiens_hsa052190.62846298
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61064682
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60988793
115Glioma_Homo sapiens_hsa052140.60706894
116Viral myocarditis_Homo sapiens_hsa054160.60405121
117Circadian rhythm_Homo sapiens_hsa047100.59297747
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58387488
119Pancreatic cancer_Homo sapiens_hsa052120.58099443
120Hepatitis B_Homo sapiens_hsa051610.57811220
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55478987
122Shigellosis_Homo sapiens_hsa051310.55457785
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55450335
124GnRH signaling pathway_Homo sapiens_hsa049120.55330359
125FoxO signaling pathway_Homo sapiens_hsa040680.53713211
126Sphingolipid metabolism_Homo sapiens_hsa006000.53012279
127Glycerolipid metabolism_Homo sapiens_hsa005610.52385659
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.52350726
129Epstein-Barr virus infection_Homo sapiens_hsa051690.50852646
130Sulfur relay system_Homo sapiens_hsa041220.49309565
131Type II diabetes mellitus_Homo sapiens_hsa049300.49239962
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.49198066
133mRNA surveillance pathway_Homo sapiens_hsa030150.48850373
134Bile secretion_Homo sapiens_hsa049760.47648548
135HTLV-I infection_Homo sapiens_hsa051660.45542840
136Pentose phosphate pathway_Homo sapiens_hsa000300.43846512
137AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42071543
138Renin-angiotensin system_Homo sapiens_hsa046140.41400211
139Autoimmune thyroid disease_Homo sapiens_hsa053200.40858861
140Platelet activation_Homo sapiens_hsa046110.40629201
141Tuberculosis_Homo sapiens_hsa051520.39299499
142Tyrosine metabolism_Homo sapiens_hsa003500.38917188

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