GPC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)6.67269063
2sarcomere organization (GO:0045214)6.62474379
3muscle filament sliding (GO:0030049)6.38694880
4actin-myosin filament sliding (GO:0033275)6.38694880
5cardiac myofibril assembly (GO:0055003)6.03211990
6myofibril assembly (GO:0030239)5.56781025
7negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.53227203
8actin-mediated cell contraction (GO:0070252)5.43052050
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.98535464
10negative regulation of potassium ion transmembrane transport (GO:1901380)4.98138129
11regulation of skeletal muscle contraction (GO:0014819)4.71689311
12actomyosin structure organization (GO:0031032)4.55543612
13regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.49070784
14cardiac muscle cell development (GO:0055013)4.45643628
15cardiac muscle contraction (GO:0060048)4.42267296
16regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.42249777
17cardiac cell development (GO:0055006)4.34470207
18sarcoplasmic reticulum calcium ion transport (GO:0070296)4.33780594
19actin filament-based movement (GO:0030048)4.31113682
20regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.28244889
21planar cell polarity pathway involved in neural tube closure (GO:0090179)4.27933753
22cell-substrate junction assembly (GO:0007044)4.04381544
23regulation of relaxation of muscle (GO:1901077)4.03390272
24striated muscle contraction (GO:0006941)4.03326116
25regulation of cell communication by electrical coupling (GO:0010649)4.02194727
26regulation of actin filament-based movement (GO:1903115)3.97460054
27regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.95172174
28regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.90170154
29skeletal muscle contraction (GO:0003009)3.85904807
30regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.84038586
31skin morphogenesis (GO:0043589)3.81437953
32desmosome organization (GO:0002934)3.80964591
33cardiac muscle tissue morphogenesis (GO:0055008)3.72993562
34response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.70472355
35ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.70199248
36adult heart development (GO:0007512)3.68479594
37muscle tissue morphogenesis (GO:0060415)3.54994909
38regulation of striated muscle contraction (GO:0006942)3.52694359
39regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.51323768
40response to inactivity (GO:0014854)3.47024953
41ventricular cardiac muscle cell action potential (GO:0086005)3.45044903
42myoblast fusion (GO:0007520)3.44542049
43heart trabecula formation (GO:0060347)3.43458441
44adherens junction assembly (GO:0034333)3.42214077
45semaphorin-plexin signaling pathway (GO:0071526)3.40839110
46collagen fibril organization (GO:0030199)3.35965085
47regulation of membrane repolarization (GO:0060306)3.35953837
48muscle cell fate commitment (GO:0042693)3.35349891
49basement membrane organization (GO:0071711)3.34445492
50dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.34172260
51focal adhesion assembly (GO:0048041)3.32795229
52cell-substrate adherens junction assembly (GO:0007045)3.32795229
53positive regulation of myotube differentiation (GO:0010831)3.32625265
54regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.31228739
55striated muscle cell development (GO:0055002)3.28498858
56skeletal muscle fiber development (GO:0048741)3.26656304
57cell adhesion mediated by integrin (GO:0033627)3.24079845
58protein heterotrimerization (GO:0070208)3.23780713
59bundle of His cell to Purkinje myocyte communication (GO:0086069)3.23670042
60negative regulation of protein localization to cell surface (GO:2000009)3.23180275
61negative regulation of chondrocyte differentiation (GO:0032331)3.20606974
62cell communication involved in cardiac conduction (GO:0086065)3.20117177
63muscle contraction (GO:0006936)3.19603494
64protein retention in ER lumen (GO:0006621)3.18843525
65regulation of sarcomere organization (GO:0060297)3.18344079
66cardiac muscle hypertrophy (GO:0003300)3.17517098
67negative regulation of striated muscle cell apoptotic process (GO:0010664)3.16917025
68syncytium formation by plasma membrane fusion (GO:0000768)3.15847861
69negative regulation of catenin import into nucleus (GO:0035414)3.12801344
70atrioventricular valve morphogenesis (GO:0003181)3.11546600
71cell migration involved in heart development (GO:0060973)3.07327558
72syncytium formation (GO:0006949)3.05720737
73Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.05094471
74maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.05030921
75muscle cell cellular homeostasis (GO:0046716)3.04383899
76negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.03711448
77striated muscle hypertrophy (GO:0014897)3.03234247
78muscle fiber development (GO:0048747)3.02634245
79kidney mesenchyme development (GO:0072074)3.01472328
80trabecula formation (GO:0060343)2.96212030
81cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.95818604
82synaptic vesicle docking involved in exocytosis (GO:0016081)2.95501386
83cell communication by electrical coupling (GO:0010644)2.92104312
84muscle cell development (GO:0055001)2.91883742
85muscle system process (GO:0003012)2.91359319
86neuron projection extension involved in neuron projection guidance (GO:1902284)2.90861236
87axon extension involved in axon guidance (GO:0048846)2.90861236
88regulation of establishment of planar polarity (GO:0090175)2.90493479
89endodermal cell differentiation (GO:0035987)2.90304723
90extracellular matrix assembly (GO:0085029)2.90197271
91positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.89112891
92regulation of axon extension involved in axon guidance (GO:0048841)2.86580247
93negative regulation of cell size (GO:0045792)2.85399226
94regulation of calcium ion transmembrane transport (GO:1903169)2.84545967
95regulation of calcium ion transmembrane transporter activity (GO:1901019)2.84545967
96collagen metabolic process (GO:0032963)2.84388011
97type B pancreatic cell proliferation (GO:0044342)2.84157262
98ventricular cardiac muscle cell development (GO:0055015)2.83487741
99endothelial cell morphogenesis (GO:0001886)2.82553639
100Golgi transport vesicle coating (GO:0048200)2.80840302
101COPI coating of Golgi vesicle (GO:0048205)2.80840302
102regulation of the force of heart contraction (GO:0002026)2.80687887
103axon extension (GO:0048675)2.80478569
104protein localization to endosome (GO:0036010)2.80378079
105tricarboxylic acid cycle (GO:0006099)2.77320013
106bone trabecula formation (GO:0060346)2.74511982
107epithelial cell-cell adhesion (GO:0090136)2.73459747
108dermatan sulfate metabolic process (GO:0030205)2.73357776
109regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.72741665
110regulation of heart rate (GO:0002027)2.72575932
111regulation of cardiac muscle cell contraction (GO:0086004)2.72008323
112adhesion of symbiont to host (GO:0044406)2.71379227
113collagen catabolic process (GO:0030574)2.71160717
114cochlea morphogenesis (GO:0090103)2.70823090
115negative regulation of potassium ion transport (GO:0043267)2.70096078
116vascular endothelial growth factor signaling pathway (GO:0038084)2.69423892
117metanephric mesenchyme development (GO:0072075)2.69379295
118regulation of cardiac muscle contraction (GO:0055117)2.69323460
119myotube cell development (GO:0014904)2.68550169
120muscle hypertrophy (GO:0014896)2.67436074
121positive regulation of blood vessel endothelial cell migration (GO:0043536)2.66663840
122muscle organ development (GO:0007517)2.65125428
123negative regulation of axon extension involved in axon guidance (GO:0048843)2.63956913
124multicellular organismal macromolecule metabolic process (GO:0044259)2.63532541
125cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.63443247
126stress fiber assembly (GO:0043149)2.63005723
127muscle structure development (GO:0061061)2.61235604
128atrial septum morphogenesis (GO:0060413)2.60080071
129cardiac muscle cell action potential involved in contraction (GO:0086002)2.60021854
130extracellular matrix disassembly (GO:0022617)2.59809691
131chondrocyte proliferation (GO:0035988)2.59545717
132positive regulation of myoblast differentiation (GO:0045663)2.57533865
133heart process (GO:0003015)2.57141918
134heart contraction (GO:0060047)2.57141918
135sodium ion export (GO:0071436)2.56566961
136hemidesmosome assembly (GO:0031581)2.56127474
137regulation of cardioblast differentiation (GO:0051890)2.56016163
138negative regulation of fatty acid transport (GO:2000192)2.55960680
139positive regulation of receptor recycling (GO:0001921)2.55384137
140regulation of striated muscle cell apoptotic process (GO:0010662)2.55325368
141cytoskeletal anchoring at plasma membrane (GO:0007016)2.54426095
142convergent extension (GO:0060026)2.54285232
143neuromuscular junction development (GO:0007528)2.53898172
144establishment of apical/basal cell polarity (GO:0035089)2.53541208
145regulation of heart contraction (GO:0008016)2.53288773
146barbed-end actin filament capping (GO:0051016)2.52846232
147cardiac muscle cell action potential (GO:0086001)2.52519874
148protein targeting to plasma membrane (GO:0072661)2.52318792
149cardiac muscle cell proliferation (GO:0060038)2.51635038
150positive regulation of axon extension (GO:0045773)2.51371776
151polarized epithelial cell differentiation (GO:0030859)2.50672294
152dermatan sulfate biosynthetic process (GO:0030208)2.49142413
153endothelial cell chemotaxis (GO:0035767)2.48437210
154neuron projection extension (GO:1990138)2.47980732
155vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.47727646
156venous blood vessel morphogenesis (GO:0048845)2.47517963
157paraxial mesoderm development (GO:0048339)2.47320640
158regulation of early endosome to late endosome transport (GO:2000641)2.46689238
159multicellular organismal metabolic process (GO:0044236)2.45930387
160chondroitin sulfate biosynthetic process (GO:0030206)2.45799952
161regulation of axon guidance (GO:1902667)2.44787024
162multicellular organismal catabolic process (GO:0044243)2.42590601
163non-canonical Wnt signaling pathway (GO:0035567)2.41261380
164establishment of tissue polarity (GO:0007164)2.40104229
165establishment of planar polarity (GO:0001736)2.40104229
166adherens junction organization (GO:0034332)2.39648961
167negative regulation of cartilage development (GO:0061037)2.38859976
168positive regulation of astrocyte differentiation (GO:0048711)2.37497019
169adhesion of symbiont to host cell (GO:0044650)2.37473373
170virion attachment to host cell (GO:0019062)2.37473373
171substrate-dependent cell migration (GO:0006929)2.36741334
172endocytic recycling (GO:0032456)2.36561059
173cell migration involved in sprouting angiogenesis (GO:0002042)2.36516373
174heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.36292725
175cellular response to vitamin (GO:0071295)2.35969272
176glial cell migration (GO:0008347)2.33671455
177insulin-like growth factor receptor signaling pathway (GO:0048009)2.32641124
178extracellular matrix organization (GO:0030198)2.31499844
179tooth mineralization (GO:0034505)2.31220852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.70738172
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.32693752
3EZH2_22144423_ChIP-Seq_EOC_Human3.15584110
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.13820568
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.95198022
6EP300_21415370_ChIP-Seq_HL-1_Mouse2.89321584
7EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.49565870
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40229964
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40229964
10* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34233180
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.25042114
12* EZH2_27304074_Chip-Seq_ESCs_Mouse2.17538116
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14036815
14TBX20_22328084_ChIP-Seq_HEART_Mouse2.13121388
15TBX20_22080862_ChIP-Seq_HEART_Mouse2.13121388
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.04958939
17WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.04160404
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.99820178
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.96550562
20WT1_19549856_ChIP-ChIP_CCG9911_Human1.95901056
21RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.95364118
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.93479526
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.90136209
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87114837
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.86676716
26* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86227690
27* EZH2_27294783_Chip-Seq_ESCs_Mouse1.84877039
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.79675326
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.78326181
30ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.76798658
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.76159098
32* RNF2_27304074_Chip-Seq_ESCs_Mouse1.75878228
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.65577333
34* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65153445
35* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65025799
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.63361294
37MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.62689521
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.62387862
39* TP53_20018659_ChIP-ChIP_R1E_Mouse1.61128013
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.60684715
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58089281
42* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55337422
43CJUN_26792858_Chip-Seq_BT549_Human1.54110606
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54042683
45DROSHA_22980978_ChIP-Seq_HELA_Human1.53781837
46KDM2B_26808549_Chip-Seq_K562_Human1.52789974
47CLOCK_20551151_ChIP-Seq_293T_Human1.52681778
48* TP53_22127205_ChIP-Seq_IMR90_Human1.50932204
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48763858
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.46056293
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42631730
52ZNF263_19887448_ChIP-Seq_K562_Human1.41314140
53TET1_21490601_ChIP-Seq_MESCs_Mouse1.39215803
54* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38284617
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35094826
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34533406
57* RING1B_27294783_Chip-Seq_ESCs_Mouse1.32645990
58UBF1/2_26484160_Chip-Seq_HMECs_Human1.30819854
59* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28433467
60SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28427037
61* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.27415336
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26807298
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26807298
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25984679
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25389037
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25388750
67P63_26484246_Chip-Seq_KERATINOCYTES_Human1.25058150
68ISL1_27105846_Chip-Seq_CPCs_Mouse1.24671250
69NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23688336
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23189595
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21985397
72* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21754529
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.21209662
74SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20721787
75* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.17816295
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17656802
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16174381
78TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15516479
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13952262
80* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12959528
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12795385
82KDM2B_26808549_Chip-Seq_DND41_Human1.12274849
83AR_21572438_ChIP-Seq_LNCaP_Human1.12159838
84* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11889934
85* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11889934
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11356655
87ESR1_21235772_ChIP-Seq_MCF-7_Human1.09375090
88* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09234380
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09070856
90TP53_18474530_ChIP-ChIP_U2OS_Human1.09015052
91TP53_23651856_ChIP-Seq_MEFs_Mouse1.08984191
92* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08877887
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.08839859
94* RING1B_27294783_Chip-Seq_NPCs_Mouse1.08626016
95AHR_22903824_ChIP-Seq_MCF-7_Human1.08262283
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08159516
97* LXR_22292898_ChIP-Seq_THP-1_Human1.07499245
98* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07013412
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06314959
100* ATF3_27146783_Chip-Seq_COLON_Human1.06075320
101OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05602575
102NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05244088
103TET1_21451524_ChIP-Seq_MESCs_Mouse1.04563290
104SMC4_20622854_ChIP-Seq_HELA_Human1.04336568
105RACK7_27058665_Chip-Seq_MCF-7_Human1.04148660
106RARB_27405468_Chip-Seq_BRAIN_Mouse1.02804762
107SA1_27219007_Chip-Seq_ERYTHROID_Human1.02686318
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02346654
109CTCF_27219007_Chip-Seq_Bcells_Human1.02044069
110PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00711117
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00025766
112* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99952859
113* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99891644
114TP63_22573176_ChIP-Seq_HFKS_Human0.99794044
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99749214
116BRD4_25478319_ChIP-Seq_HGPS_Human0.99680641
117CREB1_26743006_Chip-Seq_LNCaP_Human0.99150066
118KDM2B_26808549_Chip-Seq_JURKAT_Human0.98896556
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98149247
120* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.97703434
121SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97229390
122TP53_16413492_ChIP-PET_HCT116_Human0.95980929
123CBX2_27304074_Chip-Seq_ESCs_Mouse0.94508137
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92095902
125DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91239925
126GATA4_21415370_ChIP-Seq_HL-1_Mouse0.91178182
127ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.90930779
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90867021

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy5.33984480
2MP0002837_dystrophic_cardiac_calcinosis5.03089635
3MP0003646_muscle_fatigue3.90083764
4MP0000749_muscle_degeneration3.90032239
5MP0004084_abnormal_cardiac_muscle3.73413939
6MP0008438_abnormal_cutaneous_collagen3.55320946
7MP0000750_abnormal_muscle_regeneration2.90634101
8MP0004036_abnormal_muscle_relaxation2.79906370
9MP0004087_abnormal_muscle_fiber2.76639062
10MP0004215_abnormal_myocardial_fiber2.74683694
11MP0005503_abnormal_tendon_morphology2.59715795
12MP0005330_cardiomyopathy2.44386233
13MP0002106_abnormal_muscle_physiology2.40981769
14MP0004145_abnormal_muscle_electrophysio2.37520501
15MP0005275_abnormal_skin_tensile2.31807596
16MP0000759_abnormal_skeletal_muscle2.26034794
17MP0005623_abnormal_meninges_morphology2.25922812
18MP0000579_abnormal_nail_morphology2.25391895
19MP0002972_abnormal_cardiac_muscle2.16409913
20MP0005369_muscle_phenotype2.15989908
21MP0000733_abnormal_muscle_development2.13861800
22MP0003279_aneurysm2.13612866
23MP0003705_abnormal_hypodermis_morpholog2.12155769
24MP0005620_abnormal_muscle_contractility2.03078294
25MP0000747_muscle_weakness2.01177116
26MP0002269_muscular_atrophy1.98760728
27MP0010030_abnormal_orbit_morphology1.95632546
28MP0003137_abnormal_impulse_conducting1.90937904
29MP0001849_ear_inflammation1.82194057
30MP0010630_abnormal_cardiac_muscle1.79268061
31MP0002108_abnormal_muscle_morphology1.78699430
32MP0004233_abnormal_muscle_weight1.77913787
33MP0010368_abnormal_lymphatic_system1.76994786
34MP0008775_abnormal_heart_ventricle1.76879016
35MP0002234_abnormal_pharynx_morphology1.73545368
36MP0006138_congestive_heart_failure1.71357715
37MP0005385_cardiovascular_system_phenoty1.62049294
38MP0001544_abnormal_cardiovascular_syste1.62049294
39MP0001299_abnormal_eye_distance/1.60534652
40MP0005409_darkened_coat_color1.55748906
41MP0005023_abnormal_wound_healing1.55081028
42MP0004272_abnormal_basement_membrane1.52906800
43MP0009250_abnormal_appendicular_skeleto1.52007982
44MP0003941_abnormal_skin_development1.51999658
45MP0004484_altered_response_of1.45469081
46MP0009053_abnormal_anal_canal1.41079140
47MP0004510_myositis1.40695684
48MP0004085_abnormal_heartbeat1.33587298
49MP0003385_abnormal_body_wall1.30418425
50MP0004130_abnormal_muscle_cell1.26763837
51MP0000467_abnormal_esophagus_morphology1.26553083
52MP0001958_emphysema1.23397110
53MP0000003_abnormal_adipose_tissue1.22237507
54MP0003950_abnormal_plasma_membrane1.19130608
55MP0003566_abnormal_cell_adhesion1.18996150
56MP0004858_abnormal_nervous_system1.17900600
57MP0009384_cardiac_valve_regurgitation1.15098120
58MP0003329_amyloid_beta_deposits1.13990207
59MP0002896_abnormal_bone_mineralization1.10035112
60MP0000462_abnormal_digestive_system1.07673634
61MP0003091_abnormal_cell_migration1.07516716
62MP0003828_pulmonary_edema1.07159264
63MP0000767_abnormal_smooth_muscle1.06999235
64MP0001542_abnormal_bone_strength1.02714832
65MP0005595_abnormal_vascular_smooth1.02401681
66MP0005508_abnormal_skeleton_morphology1.01881994
67MP0004134_abnormal_chest_morphology1.00075226
68MP0002877_abnormal_melanocyte_morpholog1.00059657
69MP0000762_abnormal_tongue_morphology0.99785473
70MP0004270_analgesia0.99627305
71MP0001243_abnormal_dermal_layer0.99299754
72MP0003453_abnormal_keratinocyte_physiol0.98283030
73MP0009780_abnormal_chondrocyte_physiolo0.97418040
74MP0004185_abnormal_adipocyte_glucose0.95840830
75MP0005257_abnormal_intraocular_pressure0.95687910
76MP0000049_abnormal_middle_ear0.92207470
77MP0000428_abnormal_craniofacial_morphol0.91423609
78MP0002282_abnormal_trachea_morphology0.88447843
79MP0003221_abnormal_cardiomyocyte_apopto0.87315702
80MP0003283_abnormal_digestive_organ0.86533859
81MP0000534_abnormal_ureter_morphology0.86320901
82MP0002796_impaired_skin_barrier0.85141968
83MP0003942_abnormal_urinary_system0.84830940
84MP0000163_abnormal_cartilage_morphology0.84657374
85MP0002332_abnormal_exercise_endurance0.84464013
86MP0001348_abnormal_lacrimal_gland0.84344628
87MP0002249_abnormal_larynx_morphology0.82360111
88MP0000266_abnormal_heart_morphology0.81658336
89MP0010234_abnormal_vibrissa_follicle0.81102117
90MP0003634_abnormal_glial_cell0.80769231
91MP0003755_abnormal_palate_morphology0.80211371
92MP0000566_synostosis0.78038285
93MP0010771_integument_phenotype0.77099467
94MP0005501_abnormal_skin_physiology0.77012766
95MP0002128_abnormal_blood_circulation0.76816983
96MP0000678_abnormal_parathyroid_gland0.75610497
97MP0005666_abnormal_adipose_tissue0.73212866
98MP0000432_abnormal_head_morphology0.72710031
99MP0002127_abnormal_cardiovascular_syste0.71306995
100MP0002115_abnormal_skeleton_extremities0.71059900
101MP0000778_abnormal_nervous_system0.70347946
102MP0003935_abnormal_craniofacial_develop0.69140450
103MP0005076_abnormal_cell_differentiation0.68652344
104MP0006054_spinal_hemorrhage0.67090520
105MP0002933_joint_inflammation0.66747060
106MP0002932_abnormal_joint_morphology0.65174912
107MP0005197_abnormal_uvea_morphology0.64805932
108MP0002116_abnormal_craniofacial_bone0.63336447
109MP0000537_abnormal_urethra_morphology0.63315874
110MP0002697_abnormal_eye_size0.62734056
111MP0000343_altered_response_to0.62054601
112MP0001346_abnormal_lacrimal_gland0.61523244
113MP0005375_adipose_tissue_phenotype0.61322467
114MP0001614_abnormal_blood_vessel0.61040031
115MP0001879_abnormal_lymphatic_vessel0.59336372
116MP0002233_abnormal_nose_morphology0.59305131
117MP0001915_intracranial_hemorrhage0.57995204
118MP0002113_abnormal_skeleton_development0.57020675
119MP0002295_abnormal_pulmonary_circulatio0.56633630
120MP0003567_abnormal_fetal_cardiomyocyte0.56334749
121MP0002925_abnormal_cardiovascular_devel0.55857673
122MP0003115_abnormal_respiratory_system0.55758354
123MP0002089_abnormal_postnatal_growth/wei0.54873973
124MP0005165_increased_susceptibility_to0.54034529
125MP0000013_abnormal_adipose_tissue0.53745624
126MP0004859_abnormal_synaptic_plasticity0.53381765
127MP0002114_abnormal_axial_skeleton0.53025497
128MP0002060_abnormal_skin_morphology0.52715928
129MP0002184_abnormal_innervation0.52511443

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)4.94655405
2Type 1 muscle fiber predominance (HP:0003803)4.92131991
3Muscle fiber splitting (HP:0003555)4.72644459
4Abnormality of the calf musculature (HP:0001430)4.66401433
5Calf muscle hypertrophy (HP:0008981)4.47067106
6Increased connective tissue (HP:0009025)4.33808111
7Muscle hypertrophy of the lower extremities (HP:0008968)4.17855607
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.96458808
9Hyporeflexia of lower limbs (HP:0002600)3.87369549
10Ventricular tachycardia (HP:0004756)3.80443663
11Premature rupture of membranes (HP:0001788)3.78289805
12Exercise-induced muscle cramps (HP:0003710)3.77959475
13Muscle fiber inclusion bodies (HP:0100299)3.76823007
14EMG: myopathic abnormalities (HP:0003458)3.76206153
15Fetal akinesia sequence (HP:0001989)3.71794202
16Difficulty climbing stairs (HP:0003551)3.71437889
17Exercise-induced myalgia (HP:0003738)3.65734039
18Protrusio acetabuli (HP:0003179)3.60066596
19Atrial fibrillation (HP:0005110)3.49615726
20Right ventricular cardiomyopathy (HP:0011663)3.49290625
21Increased variability in muscle fiber diameter (HP:0003557)3.48959092
22Difficulty running (HP:0009046)3.44979098
23Abnormality of skeletal muscle fiber size (HP:0012084)3.44532977
24Vascular tortuosity (HP:0004948)3.40620367
25Mildly elevated creatine phosphokinase (HP:0008180)3.39881783
26Primary atrial arrhythmia (HP:0001692)3.29362805
27Nemaline bodies (HP:0003798)3.29126514
28Aortic dissection (HP:0002647)3.28337347
29Lipoatrophy (HP:0100578)3.20685743
30Arterial tortuosity (HP:0005116)3.19397493
31Supraventricular tachycardia (HP:0004755)3.13365776
32Popliteal pterygium (HP:0009756)3.11110655
33Supraventricular arrhythmia (HP:0005115)3.10106199
34Scapular winging (HP:0003691)3.04972116
35Abnormality of the left ventricular outflow tract (HP:0011103)3.01831517
36Subaortic stenosis (HP:0001682)3.01831517
37Aortic aneurysm (HP:0004942)2.99763673
38Ulnar bowing (HP:0003031)2.99251480
39Abnormality of dentin (HP:0010299)2.97676134
40Distal lower limb amyotrophy (HP:0008944)2.93483796
41Follicular hyperkeratosis (HP:0007502)2.92499550
42Hypoplastic ischia (HP:0003175)2.90957289
43Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.90705759
44Round ear (HP:0100830)2.90503156
45Spinal rigidity (HP:0003306)2.89958281
46Aplasia of the musculature (HP:0100854)2.86855328
47Limb-girdle muscle atrophy (HP:0003797)2.85428285
48Soft skin (HP:0000977)2.81045182
49Wormian bones (HP:0002645)2.80578968
50Myotonia (HP:0002486)2.79341100
51Cervical subluxation (HP:0003308)2.77789382
52Abnormality of the neuromuscular junction (HP:0003398)2.76885627
53Fatigable weakness (HP:0003473)2.76885627
54Thin ribs (HP:0000883)2.74547274
55Cerebral aneurysm (HP:0004944)2.74411122
56Hip contracture (HP:0003273)2.71880501
57Hyperacusis (HP:0010780)2.67023133
58Malignant hyperthermia (HP:0002047)2.66623170
59Mitral regurgitation (HP:0001653)2.65160876
60Gowers sign (HP:0003391)2.65117578
61Ankle contracture (HP:0006466)2.63197713
62Abnormality of the ischium (HP:0003174)2.58289597
63Distal upper limb amyotrophy (HP:0007149)2.54239694
64Upper limb amyotrophy (HP:0009129)2.54239694
65Lower limb amyotrophy (HP:0007210)2.51560165
66Bowel diverticulosis (HP:0005222)2.51517430
67Distal arthrogryposis (HP:0005684)2.51209103
68Broad metatarsal (HP:0001783)2.50828466
69Genu recurvatum (HP:0002816)2.48691311
70Dilated cardiomyopathy (HP:0001644)2.45680555
71Obstructive sleep apnea (HP:0002870)2.44036853
72Pterygium (HP:0001059)2.42426836
73Shallow orbits (HP:0000586)2.38727011
74Amniotic constriction ring (HP:0009775)2.37510153
75Abnormality of placental membranes (HP:0011409)2.37510153
76Bundle branch block (HP:0011710)2.37340673
77Ulnar deviation of the wrist (HP:0003049)2.34653916
78Blue sclerae (HP:0000592)2.30642094
79Prolonged QT interval (HP:0001657)2.30549818
80Aortic regurgitation (HP:0001659)2.29530310
81Biconcave vertebral bodies (HP:0004586)2.29162846
82Distal lower limb muscle weakness (HP:0009053)2.28318257
83Weak cry (HP:0001612)2.28289028
84Slender build (HP:0001533)2.27873059
85Limited hip movement (HP:0008800)2.25876070
86Vertebral compression fractures (HP:0002953)2.23901433
87Ventricular arrhythmia (HP:0004308)2.23819996
88Neck muscle weakness (HP:0000467)2.23256314
89Syncope (HP:0001279)2.21474551
90Broad face (HP:0000283)2.20714418
91Natal tooth (HP:0000695)2.20416740
92Hypoventilation (HP:0002791)2.19882421
93Achilles tendon contracture (HP:0001771)2.19592144
94Hypoplastic heart (HP:0001961)2.18811243
95Atrophic scars (HP:0001075)2.17761411
96Elbow flexion contracture (HP:0002987)2.15091677
97Myoglobinuria (HP:0002913)2.14828123
98Short nail (HP:0001799)2.14496575
99Dilatation of the ascending aorta (HP:0005111)2.13577774
100Mitral valve prolapse (HP:0001634)2.13177453
101Fragile skin (HP:0001030)2.12968514
102Asymmetric septal hypertrophy (HP:0001670)2.10238961
103Limb-girdle muscle weakness (HP:0003325)2.10225242
104Generalized muscle weakness (HP:0003324)2.09417955
105Generalized amyotrophy (HP:0003700)2.08956741
106Turricephaly (HP:0000262)2.08841293
107Akinesia (HP:0002304)2.07873814
108Abnormal atrioventricular conduction (HP:0005150)2.05960606
109Myopathic facies (HP:0002058)2.05079635
110Coronal craniosynostosis (HP:0004440)2.04610041
111Insomnia (HP:0100785)2.04473559
112Hyperextensible skin (HP:0000974)2.03980561
113Joint laxity (HP:0001388)2.03534473
114Neonatal short-limb short stature (HP:0008921)2.01936953
115Palpitations (HP:0001962)2.00145699
116Calcaneovalgus deformity (HP:0001848)2.00070050
117Centrally nucleated skeletal muscle fibers (HP:0003687)1.98447776
118Wrist flexion contracture (HP:0001239)1.97310754
119Cupped ribs (HP:0000887)1.93555354
120Stridor (HP:0010307)1.93522485
121Cystic hygroma (HP:0000476)1.93484828
122Deformed tarsal bones (HP:0008119)1.93350151
123Bulbar palsy (HP:0001283)1.93101240
124Absent phalangeal crease (HP:0006109)1.92922601
125Bowing of the arm (HP:0006488)1.91898171
126Bowed forearm bones (HP:0003956)1.91898171
127Exostoses (HP:0100777)1.91645158
128Bladder diverticulum (HP:0000015)1.91336494
129Milia (HP:0001056)1.90204282
130Lymphangioma (HP:0100764)1.89622446
131Foot dorsiflexor weakness (HP:0009027)1.89362863
132Hand muscle atrophy (HP:0009130)1.88730647
133Infantile muscular hypotonia (HP:0008947)1.88704043
134Wide anterior fontanel (HP:0000260)1.88241169
135Aneurysm (HP:0002617)1.87881555
136Abnormality of the shoulder girdle musculature (HP:0001435)1.87848342
137Abnormality of the Achilles tendon (HP:0005109)1.87775110
138Abnormality of the foot musculature (HP:0001436)1.87287517
139Peritonitis (HP:0002586)1.86081725
140Renal duplication (HP:0000075)1.85666728
141Vertebral arch anomaly (HP:0008438)1.84876194
142Disproportionate tall stature (HP:0001519)1.84647591
143Heart block (HP:0012722)1.83667771
144Overgrowth (HP:0001548)1.83601798
145Aplasia involving bones of the extremities (HP:0009825)1.82946786
146Aplasia involving bones of the upper limbs (HP:0009823)1.82946786
147Aplasia of the phalanges of the hand (HP:0009802)1.82946786
148Muscular dystrophy (HP:0003560)1.80677762
149Epiphyseal dysplasia (HP:0002656)1.80275456
150Bell-shaped thorax (HP:0001591)1.79742921
151Waddling gait (HP:0002515)1.77538248
152Long toe (HP:0010511)1.77168980
153Mitral stenosis (HP:0001718)1.74893020
154Advanced eruption of teeth (HP:0006288)1.74521196
155Ectopia lentis (HP:0001083)1.72122062
156Spondylolisthesis (HP:0003302)1.71783703
157Tibial bowing (HP:0002982)1.69574898
158Hallux valgus (HP:0001822)1.68931610
159Joint stiffness (HP:0001387)1.68911243
160Fragile nails (HP:0001808)1.68634680
161Deviation of the hallux (HP:0010051)1.67811087

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN6.16712825
2TRIB33.94657786
3DDR23.23390633
4PHKG23.14182567
5PHKG13.14182567
6OBSCN2.94101588
7PKN22.86444060
8MUSK2.60998436
9LMTK22.39887338
10DMPK2.31956088
11EPHA22.07938429
12TESK11.95486406
13MYLK1.91788990
14EPHB11.86613110
15MST1R1.81699589
16PDGFRA1.81470349
17EPHB21.80549217
18LATS21.71061986
19PAK31.64060449
20ROCK11.61757577
21ICK1.57901203
22ILK1.55242181
23ROCK21.52275914
24ERN11.50075701
25TRPM71.48026851
26PIK3CA1.46505170
27ARAF1.40529565
28MOS1.30905295
29LIMK11.30554089
30SMG11.28848262
31RIPK11.26921205
32PRKD21.26427802
33PDK41.25764066
34PDK31.25764066
35FER1.24679140
36PAK61.20952683
37PRPF4B1.18747082
38MAP3K61.18696221
39LATS11.17722514
40NEK11.16824437
41ERBB31.15872412
42ERBB41.06138054
43SIK11.05177616
44PTK2B1.04540947
45PRKD31.02615655
46PTK61.01676212
47NEK90.99517093
48BMX0.99004882
49STK38L0.98533379
50CAMK2D0.98426037
51PIM20.96071071
52PIK3CG0.95961947
53PRKD10.94448492
54STK240.92903689
55RPS6KA20.86380865
56PAK40.86108136
57TAOK20.84343571
58CAMK2G0.83090605
59CDC42BPA0.82161865
60KSR20.81193960
61RPS6KC10.79766805
62RPS6KL10.79766805
63MAP2K10.78424895
64FGFR40.77066849
65MARK20.76969561
66EPHA30.76842963
67DAPK30.72417824
68FLT30.70439956
69MAP3K70.67984819
70EPHA40.67850921
71ABL20.67183159
72RPS6KA60.66922186
73IRAK30.66790143
74MAP3K90.66240334
75CAMK2B0.66220663
76PKN10.65010149
77MARK10.64459516
78NTRK10.63926348
79CDK120.63548069
80PDK20.61826760
81CAMK2A0.61786353
82MTOR0.61033722
83MAP3K30.60296918
84PINK10.60153278
85PAK20.59303626
86PTK20.57915129
87PRKCE0.57887991
88NTRK30.57198165
89MAPK150.57130111
90MAPK120.56696428
91RET0.55869234
92PRKCH0.54800501
93PLK20.53757639
94ADRBK10.52370783
95BRAF0.51534318
96MAPKAPK30.51441263
97NTRK20.51174230
98LRRK20.51117387
99MAP3K100.50481528
100STK380.50313725
101FGFR10.49951540
102CDK140.47976149
103DYRK1B0.47765502
104PDGFRB0.46564586
105WNK40.46185720
106CDK150.45566406
107CDK180.45467915
108NME10.45312876
109TGFBR20.44396129
110EEF2K0.43435874
111CAMK40.43081886
112TYRO30.42872186
113CAMKK10.42132356
114KSR10.40920871
115MAPK70.40143855
116UHMK10.38945238
117RPS6KA10.38916857
118MINK10.38209567
119WNK10.37310405
120MET0.36956159
121PRKG20.35833461
122PDPK10.35646329
123CDK11A0.35351437
124MAP3K110.34696015
125MAP3K130.32030839
126MAPK40.31912349
127AKT20.31829320
128ERBB20.31688333
129GRK70.31515820
130STK390.31095378
131TGFBR10.30650781
132PRKAA10.29761050
133MAP3K50.29638474

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054144.08715366
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.96017862
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.43297675
4Cardiac muscle contraction_Homo sapiens_hsa042603.19483277
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.79347627
6ECM-receptor interaction_Homo sapiens_hsa045122.64772608
7Focal adhesion_Homo sapiens_hsa045102.15259111
8Viral myocarditis_Homo sapiens_hsa054162.10872099
9Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.98846966
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.98249612
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.57342458
12Parkinsons disease_Homo sapiens_hsa050121.46784637
13Axon guidance_Homo sapiens_hsa043601.42350273
14Prion diseases_Homo sapiens_hsa050201.41514232
15* Proteoglycans in cancer_Homo sapiens_hsa052051.38339651
16Tight junction_Homo sapiens_hsa045301.30449870
17Alzheimers disease_Homo sapiens_hsa050101.29425329
18Oxidative phosphorylation_Homo sapiens_hsa001901.28964379
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.27944457
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27085204
21Oxytocin signaling pathway_Homo sapiens_hsa049211.26836911
22Basal cell carcinoma_Homo sapiens_hsa052171.26431682
23Amoebiasis_Homo sapiens_hsa051461.24440307
24Adherens junction_Homo sapiens_hsa045201.23310150
25Gap junction_Homo sapiens_hsa045401.20446075
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16188694
27Hippo signaling pathway_Homo sapiens_hsa043901.11490862
28Hedgehog signaling pathway_Homo sapiens_hsa043401.11075597
29cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10324586
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02937743
31Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01539309
32Protein digestion and absorption_Homo sapiens_hsa049741.01213518
33Insulin signaling pathway_Homo sapiens_hsa049101.00633747
34Melanogenesis_Homo sapiens_hsa049160.99815212
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98960233
36Glioma_Homo sapiens_hsa052140.98162530
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94687383
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94352802
39GnRH signaling pathway_Homo sapiens_hsa049120.91886129
40Cocaine addiction_Homo sapiens_hsa050300.91452316
41Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90886644
42Melanoma_Homo sapiens_hsa052180.90167949
43Circadian entrainment_Homo sapiens_hsa047130.89124726
44PI3K-Akt signaling pathway_Homo sapiens_hsa041510.88112738
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86909977
46Calcium signaling pathway_Homo sapiens_hsa040200.86108772
47Central carbon metabolism in cancer_Homo sapiens_hsa052300.85782583
48Renal cell carcinoma_Homo sapiens_hsa052110.84888232
49Cholinergic synapse_Homo sapiens_hsa047250.84699193
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84176194
51Gastric acid secretion_Homo sapiens_hsa049710.81640322
52Renin secretion_Homo sapiens_hsa049240.81137450
53MicroRNAs in cancer_Homo sapiens_hsa052060.81099919
54Dorso-ventral axis formation_Homo sapiens_hsa043200.80916986
55Vibrio cholerae infection_Homo sapiens_hsa051100.80508659
56Notch signaling pathway_Homo sapiens_hsa043300.80035337
57Huntingtons disease_Homo sapiens_hsa050160.78234779
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78198592
59HIF-1 signaling pathway_Homo sapiens_hsa040660.77566379
60Estrogen signaling pathway_Homo sapiens_hsa049150.76998151
61Synaptic vesicle cycle_Homo sapiens_hsa047210.76975906
62Endometrial cancer_Homo sapiens_hsa052130.76706112
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.75303771
64Bladder cancer_Homo sapiens_hsa052190.75184150
65Insulin resistance_Homo sapiens_hsa049310.74541918
66Chronic myeloid leukemia_Homo sapiens_hsa052200.73750083
67Carbon metabolism_Homo sapiens_hsa012000.72924073
68VEGF signaling pathway_Homo sapiens_hsa043700.72264471
69Glucagon signaling pathway_Homo sapiens_hsa049220.71887343
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71447205
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.69373010
72Olfactory transduction_Homo sapiens_hsa047400.69132280
73Bile secretion_Homo sapiens_hsa049760.68437362
74Thyroid cancer_Homo sapiens_hsa052160.68401716
75MAPK signaling pathway_Homo sapiens_hsa040100.67405300
76Wnt signaling pathway_Homo sapiens_hsa043100.67384601
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.67351484
78AMPK signaling pathway_Homo sapiens_hsa041520.67242160
79Galactose metabolism_Homo sapiens_hsa000520.66322146
80Pentose phosphate pathway_Homo sapiens_hsa000300.66181849
81Endocytosis_Homo sapiens_hsa041440.66045744
82Type II diabetes mellitus_Homo sapiens_hsa049300.66045424
83Rap1 signaling pathway_Homo sapiens_hsa040150.65963727
84Pancreatic cancer_Homo sapiens_hsa052120.65933549
85Thyroid hormone synthesis_Homo sapiens_hsa049180.64643635
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64208959
87Small cell lung cancer_Homo sapiens_hsa052220.63129133
88ErbB signaling pathway_Homo sapiens_hsa040120.62925288
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.62439799
90Other glycan degradation_Homo sapiens_hsa005110.61935079
91Glutamatergic synapse_Homo sapiens_hsa047240.61774294
92cAMP signaling pathway_Homo sapiens_hsa040240.61760748
93Vitamin B6 metabolism_Homo sapiens_hsa007500.60850031
94Salivary secretion_Homo sapiens_hsa049700.60802747
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60754442
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60182358
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60010559
98Amphetamine addiction_Homo sapiens_hsa050310.59569727
99Choline metabolism in cancer_Homo sapiens_hsa052310.58825814
100TGF-beta signaling pathway_Homo sapiens_hsa043500.58437454
101Platelet activation_Homo sapiens_hsa046110.58208355
102Insulin secretion_Homo sapiens_hsa049110.58175259
103Propanoate metabolism_Homo sapiens_hsa006400.57705980
104mTOR signaling pathway_Homo sapiens_hsa041500.57051958
105Salmonella infection_Homo sapiens_hsa051320.55900059
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55480581
107Non-small cell lung cancer_Homo sapiens_hsa052230.55478779
108Pathways in cancer_Homo sapiens_hsa052000.55154548
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.54874225
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54121337
111Biosynthesis of amino acids_Homo sapiens_hsa012300.52175662
112Long-term potentiation_Homo sapiens_hsa047200.50697518
113Prostate cancer_Homo sapiens_hsa052150.50644553
114Dopaminergic synapse_Homo sapiens_hsa047280.50540528
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50084884
116Long-term depression_Homo sapiens_hsa047300.49931558
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48335335
118Fatty acid degradation_Homo sapiens_hsa000710.47676597
119Ras signaling pathway_Homo sapiens_hsa040140.45946286
120Ovarian steroidogenesis_Homo sapiens_hsa049130.45183715
121Fatty acid metabolism_Homo sapiens_hsa012120.43194706
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42751760
123Toxoplasmosis_Homo sapiens_hsa051450.42323130
124Starch and sucrose metabolism_Homo sapiens_hsa005000.41904721

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