GPC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-amino acid import (GO:0043092)5.49662735
2positive regulation of vascular permeability (GO:0043117)5.34994016
3regulation of synapse structural plasticity (GO:0051823)5.18943681
4alanine transport (GO:0032328)5.13917095
5amino acid import (GO:0043090)5.08243958
6locomotory exploration behavior (GO:0035641)4.71174454
7gamma-aminobutyric acid transport (GO:0015812)4.53968470
8C4-dicarboxylate transport (GO:0015740)4.50546433
9neuron cell-cell adhesion (GO:0007158)4.47625906
10response to auditory stimulus (GO:0010996)4.35067901
11neurotransmitter-gated ion channel clustering (GO:0072578)4.34680346
12cAMP catabolic process (GO:0006198)4.23137092
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.19683234
14glutamate receptor signaling pathway (GO:0007215)4.18145868
15G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.15891075
16cellular potassium ion homeostasis (GO:0030007)4.15887460
17establishment of nucleus localization (GO:0040023)4.15829705
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.12318804
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.10209304
20vocalization behavior (GO:0071625)4.09899072
21L-serine transport (GO:0015825)4.09299122
22auditory behavior (GO:0031223)3.98411283
23regulation of short-term neuronal synaptic plasticity (GO:0048172)3.97935054
24cyclic nucleotide catabolic process (GO:0009214)3.97766146
25proline transport (GO:0015824)3.95720009
26prepulse inhibition (GO:0060134)3.86867477
27postsynaptic membrane organization (GO:0001941)3.86855964
28positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.83110798
29negative regulation of synaptic transmission, GABAergic (GO:0032229)3.82206324
30axon ensheathment in central nervous system (GO:0032291)3.81205828
31central nervous system myelination (GO:0022010)3.81205828
32transmission of nerve impulse (GO:0019226)3.79512545
33regulation of glutamate receptor signaling pathway (GO:1900449)3.76496979
34synaptic transmission, glutamatergic (GO:0035249)3.74711652
35negative regulation of oligodendrocyte differentiation (GO:0048715)3.71984868
36neuronal action potential propagation (GO:0019227)3.71318333
37presynaptic membrane assembly (GO:0097105)3.69554390
38negative regulation of astrocyte differentiation (GO:0048712)3.68355724
39positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.62745180
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.59998750
41glutamate secretion (GO:0014047)3.58884491
42sodium ion export (GO:0071436)3.58684452
43atrial cardiac muscle cell action potential (GO:0086014)3.57876059
44protein localization to synapse (GO:0035418)3.56390663
45regulation of axon regeneration (GO:0048679)3.53779273
46regulation of neuron projection regeneration (GO:0070570)3.53779273
47positive regulation of cellular amide metabolic process (GO:0034250)3.49806641
48exploration behavior (GO:0035640)3.49442154
49synaptic vesicle exocytosis (GO:0016079)3.48239088
50serine transport (GO:0032329)3.45693617
51cell communication by electrical coupling (GO:0010644)3.45071135
52cochlea development (GO:0090102)3.42406535
53glial cell proliferation (GO:0014009)3.42300299
54synaptic vesicle maturation (GO:0016188)3.41405336
55negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.40894859
56negative regulation of heart rate (GO:0010459)3.40851076
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.40032934
58regulation of beta-amyloid formation (GO:1902003)3.37955291
59regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.37101844
60regulation of neuronal synaptic plasticity (GO:0048168)3.33896482
61regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.33696756
62cAMP-mediated signaling (GO:0019933)3.32134458
63cellular response to cholesterol (GO:0071397)3.31248142
64presynaptic membrane organization (GO:0097090)3.31129936
65neurotransmitter uptake (GO:0001504)3.30115002
66regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.28110414
67neuron-neuron synaptic transmission (GO:0007270)3.27051472
68layer formation in cerebral cortex (GO:0021819)3.26923119
69regulation of female receptivity (GO:0045924)3.26407495
70long-term memory (GO:0007616)3.24622782
71acidic amino acid transport (GO:0015800)3.24410511
72positive regulation of action potential (GO:0045760)3.21373297
73regulation of long-term neuronal synaptic plasticity (GO:0048169)3.20416826
74positive regulation of potassium ion transmembrane transport (GO:1901381)3.18714904
75mechanosensory behavior (GO:0007638)3.17264830
76positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.16617842
77chondroitin sulfate catabolic process (GO:0030207)3.14641648
78positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.13732138
79long-term synaptic potentiation (GO:0060291)3.11493651
80dendritic spine morphogenesis (GO:0060997)3.10942553
81positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.07715983
82response to histamine (GO:0034776)3.07052510
83neuronal stem cell maintenance (GO:0097150)3.06642355
84neuronal action potential (GO:0019228)3.05013099
85regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.04874959
86detection of mechanical stimulus involved in sensory perception (GO:0050974)3.04826894
87neurotransmitter secretion (GO:0007269)3.03772567
88regulation of synaptic vesicle exocytosis (GO:2000300)3.03621595
89dendrite morphogenesis (GO:0048813)3.00062780
90cGMP-mediated signaling (GO:0019934)2.98993633
91potassium ion import (GO:0010107)2.98614459
92startle response (GO:0001964)2.97511731
93glycine transport (GO:0015816)2.94533043
94heart valve formation (GO:0003188)2.94336958
95cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.91912269
96regulation of neurotransmitter levels (GO:0001505)2.90727704
97regulation of excitatory postsynaptic membrane potential (GO:0060079)2.90523316
98gamma-aminobutyric acid signaling pathway (GO:0007214)2.89493040
99cyclic-nucleotide-mediated signaling (GO:0019935)2.89443664
100regulation of amyloid precursor protein catabolic process (GO:1902991)2.89128846
101cellular sodium ion homeostasis (GO:0006883)2.88374333
102negative regulation of glial cell differentiation (GO:0045686)2.87663872
103regulation of phospholipid biosynthetic process (GO:0071071)2.87396541
104detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.86663490
105positive regulation of synaptic transmission, GABAergic (GO:0032230)2.86577599
106regulation of cardiac muscle cell contraction (GO:0086004)2.86482460
107neuron fate determination (GO:0048664)2.86108913
108neuron recognition (GO:0008038)2.85677308
109brain morphogenesis (GO:0048854)2.84411972
110potassium ion homeostasis (GO:0055075)2.82927333
111tachykinin receptor signaling pathway (GO:0007217)2.82544236
112negative regulation of heart contraction (GO:0045822)2.82473584
113synaptic vesicle docking involved in exocytosis (GO:0016081)2.81926738
114positive regulation of dendritic spine development (GO:0060999)2.81681597
115negative regulation of vascular permeability (GO:0043116)2.81397683
116membrane depolarization during action potential (GO:0086010)2.81259963
117oligodendrocyte differentiation (GO:0048709)2.80624382
118regulation of heat generation (GO:0031650)2.79958584
119female mating behavior (GO:0060180)2.79352594
120L-glutamate transport (GO:0015813)2.79115769
121synaptic vesicle endocytosis (GO:0048488)2.79007688
122neurotransmitter transport (GO:0006836)2.78914763
123regulation of dendritic spine morphogenesis (GO:0061001)2.78297123
124regulation of respiratory system process (GO:0044065)2.77595322
125regulation of inositol phosphate biosynthetic process (GO:0010919)2.76935702
126regulation of synaptic plasticity (GO:0048167)2.76612809
127positive regulation of synapse assembly (GO:0051965)2.76231065
128regulation of synaptic vesicle transport (GO:1902803)2.75892971
129regulation of postsynaptic membrane potential (GO:0060078)2.75614264
130negative regulation of axon extension (GO:0030517)2.74590963
131membrane repolarization (GO:0086009)2.74281854
132cerebellar granule cell differentiation (GO:0021707)2.73917558
133neuromuscular synaptic transmission (GO:0007274)2.73302162
134dermatan sulfate biosynthetic process (GO:0030208)2.72982236
135regulation of cell communication by electrical coupling (GO:0010649)2.72225849
136negative regulation of dendrite development (GO:2000171)2.71712423
137nucleus localization (GO:0051647)2.70459824
138regulation of neurotransmitter secretion (GO:0046928)2.70436100
139retinal cone cell development (GO:0046549)2.66553263
140hyperosmotic salinity response (GO:0042538)2.64155671
141regulation of astrocyte differentiation (GO:0048710)2.63554509
142SMAD protein signal transduction (GO:0060395)2.59482485

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.70079103
2GBX2_23144817_ChIP-Seq_PC3_Human3.70614007
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07606952
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06781483
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96300373
6* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.75978580
7AR_21572438_ChIP-Seq_LNCaP_Human2.66197442
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.64035555
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60947867
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58755999
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57764809
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57764809
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52371811
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43765875
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.43478759
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42322381
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31929882
18REST_21632747_ChIP-Seq_MESCs_Mouse2.25828226
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.18658680
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.17700047
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.14169844
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10398292
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.08305278
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07108579
25DROSHA_22980978_ChIP-Seq_HELA_Human2.07017307
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.88953198
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78949555
28* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77563466
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.74303590
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.69350746
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69275964
32P300_19829295_ChIP-Seq_ESCs_Human1.64560068
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63541208
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62031290
35* EWS_26573619_Chip-Seq_HEK293_Human1.61981439
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.61004423
37SMAD4_21799915_ChIP-Seq_A2780_Human1.58961642
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.58408451
39* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56469352
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.54864106
41TAF15_26573619_Chip-Seq_HEK293_Human1.54227197
42* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53262364
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45028081
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42115290
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40134180
46* SMAD3_21741376_ChIP-Seq_EPCs_Human1.39441457
47* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38794725
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.35051741
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34008464
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33677602
51* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32605202
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.31680657
53AR_25329375_ChIP-Seq_VCAP_Human1.31279575
54* RING1B_27294783_Chip-Seq_ESCs_Mouse1.30761069
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30693513
56* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29161571
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26740144
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26282427
59* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25603930
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24418443
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.22456035
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21795351
63TP53_16413492_ChIP-PET_HCT116_Human1.21155591
64* STAT3_23295773_ChIP-Seq_U87_Human1.20962810
65TAL1_26923725_Chip-Seq_HPCs_Mouse1.20795410
66* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18437109
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.18289906
68* SOX2_21211035_ChIP-Seq_LN229_Gbm1.17347338
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17189136
70MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16427191
71TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15629343
72STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15624034
73CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15302921
74TP53_18474530_ChIP-ChIP_U2OS_Human1.14588672
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14093548
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13052337
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12997005
78* JUN_21703547_ChIP-Seq_K562_Human1.12253277
79SOX9_26525672_Chip-Seq_HEART_Mouse1.12086648
80BCAT_22108803_ChIP-Seq_LS180_Human1.11915343
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11851065
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.11026345
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10651505
84* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10117435
85* AR_19668381_ChIP-Seq_PC3_Human1.09947751
86* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08190349
87TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07747853
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07245587
89TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06690736
90* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05781841
91* TCF4_23295773_ChIP-Seq_U87_Human1.05644167
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04720571
93* RUNX2_22187159_ChIP-Seq_PCA_Human1.04413523
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04263821
95* RNF2_27304074_Chip-Seq_NSC_Mouse1.03130659
96* FUS_26573619_Chip-Seq_HEK293_Human1.02205309
97E2F1_18555785_Chip-Seq_ESCs_Mouse1.01849846
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01735753
99* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01448627
100RXR_22108803_ChIP-Seq_LS180_Human1.01320678
101SOX2_18555785_Chip-Seq_ESCs_Mouse1.01176779
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01164638
103RING1B_27294783_Chip-Seq_NPCs_Mouse1.01149509
104P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01105006
105* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00720542
106IGF1R_20145208_ChIP-Seq_DFB_Human0.99843536
107* PRDM14_20953172_ChIP-Seq_ESCs_Human0.98579450
108SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98490712
109ARNT_22903824_ChIP-Seq_MCF-7_Human0.98396375
110* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98000162
111TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94346702
112CMYC_18555785_Chip-Seq_ESCs_Mouse0.93981232
113ER_23166858_ChIP-Seq_MCF-7_Human0.93500560
114VDR_22108803_ChIP-Seq_LS180_Human0.92955562
115* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92586127
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92490605
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92490605
118ZNF274_21170338_ChIP-Seq_K562_Hela0.92389016
119EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92182148
120P53_22387025_ChIP-Seq_ESCs_Mouse0.92168023
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91390407
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90908604
123TP53_20018659_ChIP-ChIP_R1E_Mouse0.88050293

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.74174719
2MP0003136_yellow_coat_color4.12802974
3MP0003880_abnormal_central_pattern3.72922385
4MP0003635_abnormal_synaptic_transmissio3.32059053
5MP0001486_abnormal_startle_reflex3.12319472
6MP0004270_analgesia3.00823481
7MP0005171_absent_coat_pigmentation2.97568141
8MP0009745_abnormal_behavioral_response2.90135321
9MP0000569_abnormal_digit_pigmentation2.78848465
10MP0009046_muscle_twitch2.68453895
11MP0002064_seizures2.68240104
12MP0002063_abnormal_learning/memory/cond2.63021792
13MP0005423_abnormal_somatic_nervous2.57940115
14MP0002572_abnormal_emotion/affect_behav2.52333112
15MP0004858_abnormal_nervous_system2.45742731
16MP0001968_abnormal_touch/_nociception2.43130504
17MP0003690_abnormal_glial_cell2.31516398
18MP0005646_abnormal_pituitary_gland2.28702108
19MP0004885_abnormal_endolymph2.23918570
20MP0003329_amyloid_beta_deposits2.19582488
21MP0002272_abnormal_nervous_system2.17654641
22MP0002734_abnormal_mechanical_nocicepti2.16461348
23MP0001440_abnormal_grooming_behavior2.16088787
24MP0002736_abnormal_nociception_after2.12503032
25MP0010386_abnormal_urinary_bladder1.98580579
26MP0002254_reproductive_system_inflammat1.96588156
27MP0001501_abnormal_sleep_pattern1.96290104
28MP0002234_abnormal_pharynx_morphology1.91453158
29MP0001502_abnormal_circadian_rhythm1.90225192
30MP0008569_lethality_at_weaning1.84755646
31MP0002733_abnormal_thermal_nociception1.79464243
32MP0002067_abnormal_sensory_capabilities1.79362024
33MP0005645_abnormal_hypothalamus_physiol1.78140384
34MP0000778_abnormal_nervous_system1.78008396
35MP0001970_abnormal_pain_threshold1.77947049
36MP0001346_abnormal_lacrimal_gland1.76889301
37MP0002557_abnormal_social/conspecific_i1.74913485
38MP0002653_abnormal_ependyma_morphology1.72396810
39MP0002638_abnormal_pupillary_reflex1.69000605
40MP0009780_abnormal_chondrocyte_physiolo1.59542305
41MP0002735_abnormal_chemical_nociception1.58912093
42MP0001984_abnormal_olfaction1.56196092
43MP0005623_abnormal_meninges_morphology1.54627627
44MP0004142_abnormal_muscle_tone1.48587896
45MP0001188_hyperpigmentation1.47888325
46MP0001485_abnormal_pinna_reflex1.47603330
47MP0001905_abnormal_dopamine_level1.44129455
48MP0002928_abnormal_bile_duct1.43248706
49MP0003634_abnormal_glial_cell1.40389226
50MP0006292_abnormal_olfactory_placode1.36949721
51MP0003633_abnormal_nervous_system1.36691145
52MP0001529_abnormal_vocalization1.34366872
53MP0002882_abnormal_neuron_morphology1.33716411
54MP0004742_abnormal_vestibular_system1.33221512
55MP0004924_abnormal_behavior1.32821280
56MP0005386_behavior/neurological_phenoty1.32821280
57MP0002822_catalepsy1.32571741
58MP0002184_abnormal_innervation1.31886707
59MP0003631_nervous_system_phenotype1.31767319
60MP0000013_abnormal_adipose_tissue1.31031579
61MP0008057_abnormal_DNA_replication1.31025854
62MP0003868_abnormal_feces_composition1.28555889
63MP0003632_abnormal_nervous_system1.28049451
64MP0001963_abnormal_hearing_physiology1.27239145
65MP0005551_abnormal_eye_electrophysiolog1.26420024
66MP0000920_abnormal_myelination1.23773647
67MP0000955_abnormal_spinal_cord1.23698918
68MP0002066_abnormal_motor_capabilities/c1.19659193
69MP0005187_abnormal_penis_morphology1.16074233
70MP0001986_abnormal_taste_sensitivity1.15648943
71MP0003122_maternal_imprinting1.13539706
72MP0006276_abnormal_autonomic_nervous1.10664672
73MP0008058_abnormal_DNA_repair1.10525532
74MP0005409_darkened_coat_color1.08642235
75MP0000026_abnormal_inner_ear1.06792332
76MP0000604_amyloidosis1.05104647
77MP0002909_abnormal_adrenal_gland1.03609631
78MP0003075_altered_response_to1.02869607
79MP0003121_genomic_imprinting1.01527296
80MP0002152_abnormal_brain_morphology1.01253012
81MP0004811_abnormal_neuron_physiology0.96541800
82MP0002229_neurodegeneration0.96163852
83MP0009384_cardiac_valve_regurgitation0.95324198
84MP0001664_abnormal_digestion0.95259317
85MP0005379_endocrine/exocrine_gland_phen0.94736400
86MP0003137_abnormal_impulse_conducting0.94698993
87MP0000566_synostosis0.92862578
88MP0002752_abnormal_somatic_nervous0.91716618
89MP0002751_abnormal_autonomic_nervous0.91680886
90MP0000579_abnormal_nail_morphology0.90748088
91MP0005377_hearing/vestibular/ear_phenot0.89710130
92MP0003878_abnormal_ear_physiology0.89710130
93MP0005253_abnormal_eye_physiology0.88833555
94MP0001177_atelectasis0.88218630
95MP0003183_abnormal_peptide_metabolism0.86968637
96MP0005503_abnormal_tendon_morphology0.85834385
97MP0005595_abnormal_vascular_smooth0.83417443
98MP0000631_abnormal_neuroendocrine_gland0.83190269
99MP0003283_abnormal_digestive_organ0.82325169
100MP0003879_abnormal_hair_cell0.78005782
101MP0002069_abnormal_eating/drinking_beha0.76198994
102MP0005084_abnormal_gallbladder_morpholo0.75822003
103MP0004215_abnormal_myocardial_fiber0.73673430
104MP0000049_abnormal_middle_ear0.73370480
105MP0001299_abnormal_eye_distance/0.73091407
106MP0004147_increased_porphyrin_level0.73025519
107MP0002090_abnormal_vision0.72472026
108MP0000383_abnormal_hair_follicle0.71971565
109MP0006072_abnormal_retinal_apoptosis0.71596976
110MP0002938_white_spotting0.69727109
111MP0008877_abnormal_DNA_methylation0.68483917
112MP0005410_abnormal_fertilization0.68385780
113MP0000465_gastrointestinal_hemorrhage0.66579417
114MP0005167_abnormal_blood-brain_barrier0.66233316
115MP0005195_abnormal_posterior_eye0.65655258
116MP0005174_abnormal_tail_pigmentation0.64916400
117MP0003119_abnormal_digestive_system0.64515984
118MP0008872_abnormal_physiological_respon0.62984025
119MP0003787_abnormal_imprinting0.62242954
120MP0008874_decreased_physiological_sensi0.61537715
121MP0005535_abnormal_body_temperature0.60980698
122MP0004085_abnormal_heartbeat0.59592130
123MP0000751_myopathy0.58401708
124MP0003938_abnormal_ear_development0.58333865
125MP0000462_abnormal_digestive_system0.58091818
126MP0002249_abnormal_larynx_morphology0.57496173

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.15693985
2Megalencephaly (HP:0001355)5.77831323
3Aplasia involving bones of the upper limbs (HP:0009823)5.33599297
4Aplasia of the phalanges of the hand (HP:0009802)5.33599297
5Aplasia involving bones of the extremities (HP:0009825)5.33599297
6Myokymia (HP:0002411)4.47702700
7Neurofibrillary tangles (HP:0002185)4.29727524
8Epileptic encephalopathy (HP:0200134)4.02484926
9Focal seizures (HP:0007359)3.93182736
10Oligodactyly (hands) (HP:0001180)3.83614652
11Hemiparesis (HP:0001269)3.62077040
12Abnormality of binocular vision (HP:0011514)3.52073256
13Diplopia (HP:0000651)3.52073256
14Morphological abnormality of the inner ear (HP:0011390)3.27651103
15Clumsiness (HP:0002312)3.27462566
16Cerebral inclusion bodies (HP:0100314)3.21606082
17Abnormality of secondary sexual hair (HP:0009888)3.20476210
18Abnormality of the axillary hair (HP:0100134)3.20476210
19Progressive cerebellar ataxia (HP:0002073)3.19624949
20Generalized tonic-clonic seizures (HP:0002069)3.17328417
21Febrile seizures (HP:0002373)3.11866494
22Anterior segment dysgenesis (HP:0007700)3.07430407
23Hyperventilation (HP:0002883)3.06141430
24Supranuclear gaze palsy (HP:0000605)3.03284261
25Hemiplegia (HP:0002301)2.95014179
26Hypoplastic left heart (HP:0004383)2.94461295
27Abnormality of cochlea (HP:0000375)2.93766615
28Action tremor (HP:0002345)2.84089890
29Pheochromocytoma (HP:0002666)2.83096841
30Blue irides (HP:0000635)2.80842332
31Atonic seizures (HP:0010819)2.78766930
32Molar tooth sign on MRI (HP:0002419)2.75104627
33Abnormality of midbrain morphology (HP:0002418)2.75104627
34Postural instability (HP:0002172)2.69193393
35Visual hallucinations (HP:0002367)2.68120440
36Abnormal eating behavior (HP:0100738)2.63421951
37Esophageal atresia (HP:0002032)2.62141644
38Decreased central vision (HP:0007663)2.61537004
39Truncal ataxia (HP:0002078)2.61250105
40Long nose (HP:0003189)2.60138161
41Dialeptic seizures (HP:0011146)2.59260925
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.58270015
43Absent/shortened dynein arms (HP:0200106)2.58270015
44Mixed hearing impairment (HP:0000410)2.58145335
45Absence seizures (HP:0002121)2.55309246
46Abnormality of alanine metabolism (HP:0010916)2.54607325
47Hyperalaninemia (HP:0003348)2.54607325
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54607325
49White forelock (HP:0002211)2.51359250
50Oligodactyly (HP:0012165)2.50208276
51Stomach cancer (HP:0012126)2.43118641
52Status epilepticus (HP:0002133)2.38509396
53Polyphagia (HP:0002591)2.38407994
54Abnormality of the dental pulp (HP:0006479)2.37467823
55Postural tremor (HP:0002174)2.37438731
56Dysdiadochokinesis (HP:0002075)2.36276718
57Ulnar claw (HP:0001178)2.35558431
58Broad-based gait (HP:0002136)2.34182054
59Abnormal auditory evoked potentials (HP:0006958)2.31465125
60Absent hair (HP:0002298)2.29390036
61Patchy hypopigmentation of hair (HP:0011365)2.28742828
62Amblyopia (HP:0000646)2.26333402
63Abnormality of the labia minora (HP:0012880)2.26146897
64Hypoplastic heart (HP:0001961)2.25304746
65Split foot (HP:0001839)2.24505381
66Neuroendocrine neoplasm (HP:0100634)2.23270669
67Humeroradial synostosis (HP:0003041)2.22346102
68Synostosis involving the elbow (HP:0003938)2.22346102
69Nephronophthisis (HP:0000090)2.18960745
70Drooling (HP:0002307)2.17708954
71Excessive salivation (HP:0003781)2.17708954
72Dysmetria (HP:0001310)2.17118762
73Anophthalmia (HP:0000528)2.16099115
74Cutaneous syndactyly (HP:0012725)2.14105900
75Gastrointestinal atresia (HP:0002589)2.11864506
76Abnormal ciliary motility (HP:0012262)2.10435879
77Abnormality of permanent molar morphology (HP:0011071)2.09611698
78Abnormality of the dental root (HP:0006486)2.09611698
79Taurodontia (HP:0000679)2.09611698
80Paraparesis (HP:0002385)2.08314749
81Spastic paraparesis (HP:0002313)2.07325981
82Ankle clonus (HP:0011448)2.07118448
83Delusions (HP:0000746)2.06083772
84Papillary thyroid carcinoma (HP:0002895)2.06006624
85Large for gestational age (HP:0001520)2.05167115
86Gaze-evoked nystagmus (HP:0000640)2.04605305
87Abnormality of molar (HP:0011077)2.04530404
88Abnormality of molar morphology (HP:0011070)2.04530404
89Anxiety (HP:0000739)2.03530538
90Abnormality of the middle phalanges of the toes (HP:0010183)2.02689152
91Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.02624303
92Narrow nasal bridge (HP:0000446)2.01078095
93Urinary urgency (HP:0000012)1.95460458
94Decreased lacrimation (HP:0000633)1.93437622
95Depression (HP:0000716)1.90585960
96Midline defect of the nose (HP:0004122)1.89806758
97Tubular atrophy (HP:0000092)1.89787901
98Impaired vibration sensation in the lower limbs (HP:0002166)1.89394035
99Metabolic alkalosis (HP:0200114)1.87735180
100Intention tremor (HP:0002080)1.86417863
101Increased circulating renin level (HP:0000848)1.86066516
102Thickened helices (HP:0000391)1.84727576
103Cerebral hypomyelination (HP:0006808)1.83099315
104Aplasia/Hypoplasia of the fibula (HP:0006492)1.82809838
105Cutaneous finger syndactyly (HP:0010554)1.82061554
106Lower limb muscle weakness (HP:0007340)1.81660704
107True hermaphroditism (HP:0010459)1.81469744
108Urinary bladder sphincter dysfunction (HP:0002839)1.81040994
109Peripheral hypomyelination (HP:0007182)1.80628501
110CNS hypomyelination (HP:0003429)1.80475619
111Polydipsia (HP:0001959)1.79111786
112Abnormal drinking behavior (HP:0030082)1.79111786
113Fibular aplasia (HP:0002990)1.79092768
114Limb dystonia (HP:0002451)1.78773684
115Myelomeningocele (HP:0002475)1.78156547
116Chronic hepatic failure (HP:0100626)1.78138598
117Ventricular fibrillation (HP:0001663)1.78099668
118Gait imbalance (HP:0002141)1.77080288
119Progressive inability to walk (HP:0002505)1.76852163
120Retinal dysplasia (HP:0007973)1.76080901
121Recurrent corneal erosions (HP:0000495)1.74541765
122Generalized myoclonic seizures (HP:0002123)1.74164093
123Bifid tongue (HP:0010297)1.73872233
124Rigidity (HP:0002063)1.73599228
125Abnormality of the renal medulla (HP:0100957)1.73424458
126Thyroid carcinoma (HP:0002890)1.73175459
127Stereotypic behavior (HP:0000733)1.72390050
128Spastic gait (HP:0002064)1.72240277
129EEG with generalized epileptiform discharges (HP:0011198)1.72186880
130Fair hair (HP:0002286)1.72090355
131Abnormal social behavior (HP:0012433)1.71872171
132Impaired social interactions (HP:0000735)1.71872171
133Bradykinesia (HP:0002067)1.70881941
134Alacrima (HP:0000522)1.70850939
135Poor eye contact (HP:0000817)1.70300887
136Protruding tongue (HP:0010808)1.69651031
137Median cleft lip (HP:0000161)1.69384701
138Genital tract atresia (HP:0001827)1.68872977
139Intellectual disability, profound (HP:0002187)1.68492097
140Fibular hypoplasia (HP:0003038)1.67576346
141Abnormality of salivation (HP:0100755)1.66132068
142Vaginal atresia (HP:0000148)1.64637055
143Morphological abnormality of the middle ear (HP:0008609)1.63741510
144Hypsarrhythmia (HP:0002521)1.63127398
145Confusion (HP:0001289)1.63038527
146Epileptiform EEG discharges (HP:0011182)1.62385808
147Abnormality of the ischium (HP:0003174)1.61074686
148Pancreatic fibrosis (HP:0100732)1.59933913
149Aplasia/Hypoplasia of the tibia (HP:0005772)1.59888405
150Abnormal respiratory motile cilium physiology (HP:0012261)1.59789803
151Mutism (HP:0002300)1.59430423
152Cerebellar dysplasia (HP:0007033)1.58887172
153Short hallux (HP:0010109)1.57183416
154Abnormality of the 4th metacarpal (HP:0010012)1.56827846
155Hamartoma (HP:0010566)1.56769260
156Abnormality of the astrocytes (HP:0100707)1.56207943
157Medial flaring of the eyebrow (HP:0010747)1.56106205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.24885224
2EPHA45.42346505
3TNIK3.69792298
4NTRK33.40117669
5LMTK23.39683819
6CASK3.33243523
7NTRK23.11573558
8PRKD33.03077892
9PHKG12.97737106
10PHKG22.97737106
11TSSK62.67963160
12MUSK2.25663556
13MARK12.24260698
14MAP2K72.19415311
15MAPKAPK51.95393739
16MAPK131.94562929
17MAP3K41.93809685
18VRK11.88354547
19MINK11.72569617
20PDK21.68562371
21PRPF4B1.59499288
22CAMKK21.56463414
23SGK21.53353101
24SGK4941.49994944
25SGK2231.49994944
26MAP3K91.49727104
27RIPK41.45924750
28WEE11.41996370
29NTRK11.33298855
30PINK11.30993114
31TLK11.28371120
32CDK51.26569657
33PAK61.26290572
34CSNK1G31.23407585
35PRKCG1.22227249
36TRIM281.19848755
37MKNK11.19302689
38WNK41.18113974
39STK241.16887950
40SGK31.14644864
41CSNK1G11.14301618
42OXSR11.13849487
43CSNK1A1L1.13000896
44FES1.12427420
45DAPK21.09217434
46FGR1.08790343
47RPS6KB21.08655013
48MAP3K131.08523579
49MAP3K121.07864794
50MAP2K41.07168008
51ZAK1.02251943
52PNCK1.00838067
53CDK191.00706473
54CDC70.98305597
55SIK20.95061518
56CAMK2A0.94150825
57PLK20.93700603
58PRKCE0.92581440
59PRKCH0.85652019
60NEK60.84792096
61PKN10.83050966
62MAPK120.81949228
63GRK50.78999000
64CAMKK10.78674121
65SGK10.77655751
66AKT30.77426069
67STK390.76081142
68TNK20.75565782
69SIK10.74058022
70MAP3K70.74045504
71FRK0.72274078
72TIE10.72042847
73BCR0.70323448
74CAMK10.70244895
75BMPR20.69558212
76STK380.68735907
77DYRK1A0.67504474
78PAK20.67245169
79PAK30.65747678
80INSRR0.65216675
81TYRO30.65045598
82ADRBK10.64127734
83CAMK2B0.63877348
84GRK70.61026909
85CAMK1G0.57945684
86RPS6KA50.57868287
87EEF2K0.57454862
88PRKCQ0.57184945
89PRKD20.57086571
90ADRBK20.56968177
91UHMK10.55800676
92RPS6KB10.55574440
93MARK20.51932300
94MET0.50864228
95PBK0.50637604
96ROCK20.50075805
97CDK30.49985869
98CAMK2G0.49238885
99CDK150.49194821
100PLK30.48930292
101CDK80.48892000
102CDK180.48878672
103STK110.48800874
104MAPK70.47636786
105MATK0.47577449
106KSR10.47540033
107WNK10.47513871
108PRKACA0.45762946
109DDR20.45262506
110SCYL20.45026934
111PRKD10.44880164
112AURKA0.44825050
113CSNK1G20.44620412
114RPS6KA30.44475746
115ERBB20.43939621
116CCNB10.43887073
117PRKG10.43266607
118FGFR20.42910281
119ROCK10.42836563
120PRKCA0.42571189
121KSR20.41217940
122CDK140.40910309
123CDC42BPA0.40580175
124CDK11A0.40339505
125FYN0.40179467
126PRKCZ0.39694928
127MAPK40.38705434
128DAPK10.37577831
129CSNK1E0.37239752
130MAPK100.37205865
131CSNK1A10.36786364
132ARAF0.36750462
133DAPK30.36310891
134NME10.35707165
135CAMK2D0.35349033
136PDPK10.34851037
137MAPKAPK30.34799235
138LATS20.34458713
139GRK10.34289001
140STK160.33854046
141DMPK0.33682646
142CAMK1D0.32751247
143PRKACB0.32210526
144AKT20.31720901
145ERBB30.28766883

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.83760833
2Nitrogen metabolism_Homo sapiens_hsa009103.06665533
3Fatty acid biosynthesis_Homo sapiens_hsa000612.91548461
4Glutamatergic synapse_Homo sapiens_hsa047242.72454961
5GABAergic synapse_Homo sapiens_hsa047272.68405766
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.40137640
7Morphine addiction_Homo sapiens_hsa050322.37738935
8Circadian entrainment_Homo sapiens_hsa047132.31907689
9Olfactory transduction_Homo sapiens_hsa047402.31675734
10Salivary secretion_Homo sapiens_hsa049702.22746575
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.17287883
12Insulin secretion_Homo sapiens_hsa049112.00870843
13Synaptic vesicle cycle_Homo sapiens_hsa047211.97082934
14Amphetamine addiction_Homo sapiens_hsa050311.92156164
15Gastric acid secretion_Homo sapiens_hsa049711.90033923
16Long-term potentiation_Homo sapiens_hsa047201.86898155
17Cocaine addiction_Homo sapiens_hsa050301.83026656
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77949643
19Calcium signaling pathway_Homo sapiens_hsa040201.75447644
20Taste transduction_Homo sapiens_hsa047421.69927053
21Systemic lupus erythematosus_Homo sapiens_hsa053221.66890372
22Serotonergic synapse_Homo sapiens_hsa047261.63393009
23Dopaminergic synapse_Homo sapiens_hsa047281.53523373
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52690723
25Renin secretion_Homo sapiens_hsa049241.45148311
26Cholinergic synapse_Homo sapiens_hsa047251.41687640
27Long-term depression_Homo sapiens_hsa047301.37283775
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32572783
29cAMP signaling pathway_Homo sapiens_hsa040241.30204392
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.25781890
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17851474
32Steroid biosynthesis_Homo sapiens_hsa001001.16434928
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15234374
34Oxytocin signaling pathway_Homo sapiens_hsa049211.12396886
35Axon guidance_Homo sapiens_hsa043601.12241626
36Circadian rhythm_Homo sapiens_hsa047101.10731375
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08146066
38Melanogenesis_Homo sapiens_hsa049161.08067708
39Fatty acid metabolism_Homo sapiens_hsa012121.07786390
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02326530
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01020839
42Gap junction_Homo sapiens_hsa045401.00032172
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99976683
44Pancreatic secretion_Homo sapiens_hsa049720.99182297
45GnRH signaling pathway_Homo sapiens_hsa049120.98557835
46ABC transporters_Homo sapiens_hsa020100.95651825
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93168746
48Hippo signaling pathway_Homo sapiens_hsa043900.92614029
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91161871
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90747081
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.88855418
52Oocyte meiosis_Homo sapiens_hsa041140.88703483
53Collecting duct acid secretion_Homo sapiens_hsa049660.86534357
54Arginine biosynthesis_Homo sapiens_hsa002200.86436271
55Cardiac muscle contraction_Homo sapiens_hsa042600.84823580
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84575004
57Sphingolipid metabolism_Homo sapiens_hsa006000.84358030
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82400217
59Bile secretion_Homo sapiens_hsa049760.79825047
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79288702
61Phototransduction_Homo sapiens_hsa047440.78183749
62Ether lipid metabolism_Homo sapiens_hsa005650.77331119
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77223464
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76545132
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.75303165
66Dorso-ventral axis formation_Homo sapiens_hsa043200.74672017
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72785430
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.72586572
69Thyroid hormone synthesis_Homo sapiens_hsa049180.71167654
70Mineral absorption_Homo sapiens_hsa049780.70897387
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67964986
72Fatty acid elongation_Homo sapiens_hsa000620.66345111
73Purine metabolism_Homo sapiens_hsa002300.66224927
74ErbB signaling pathway_Homo sapiens_hsa040120.65968498
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64006868
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63299289
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63160914
78Estrogen signaling pathway_Homo sapiens_hsa049150.62850164
79Linoleic acid metabolism_Homo sapiens_hsa005910.61231603
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59520703
81African trypanosomiasis_Homo sapiens_hsa051430.58243165
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57152212
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57077308
84Tryptophan metabolism_Homo sapiens_hsa003800.57030931
85Dilated cardiomyopathy_Homo sapiens_hsa054140.57011532
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56492565
87Choline metabolism in cancer_Homo sapiens_hsa052310.53281328
88Glioma_Homo sapiens_hsa052140.51904817
89Fatty acid degradation_Homo sapiens_hsa000710.51869433
90Rap1 signaling pathway_Homo sapiens_hsa040150.51737147
91Ras signaling pathway_Homo sapiens_hsa040140.51414258
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51270936
93MAPK signaling pathway_Homo sapiens_hsa040100.49259797
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.48944820
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.48483982
96Ovarian steroidogenesis_Homo sapiens_hsa049130.48347775
97Type II diabetes mellitus_Homo sapiens_hsa049300.48191741
98Wnt signaling pathway_Homo sapiens_hsa043100.47870159
99Type I diabetes mellitus_Homo sapiens_hsa049400.47696960
100Protein digestion and absorption_Homo sapiens_hsa049740.47419359
101Butanoate metabolism_Homo sapiens_hsa006500.46497098
102Histidine metabolism_Homo sapiens_hsa003400.45659212
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44229758
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43837806
105Glucagon signaling pathway_Homo sapiens_hsa049220.43716244
106PPAR signaling pathway_Homo sapiens_hsa033200.42658935
107beta-Alanine metabolism_Homo sapiens_hsa004100.42601461
108Folate biosynthesis_Homo sapiens_hsa007900.42572309
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42075606
110Alzheimers disease_Homo sapiens_hsa050100.38713370
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38469866
112Parkinsons disease_Homo sapiens_hsa050120.37728424
113Tight junction_Homo sapiens_hsa045300.35919228
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.35701235
115Vibrio cholerae infection_Homo sapiens_hsa051100.35506548
116Basal cell carcinoma_Homo sapiens_hsa052170.34801411
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33461438
118Hedgehog signaling pathway_Homo sapiens_hsa043400.32178601
119TGF-beta signaling pathway_Homo sapiens_hsa043500.29519243
120Vitamin digestion and absorption_Homo sapiens_hsa049770.29008643
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28899299
122Peroxisome_Homo sapiens_hsa041460.28199248
123Alcoholism_Homo sapiens_hsa050340.27014860
124Cysteine and methionine metabolism_Homo sapiens_hsa002700.26627459
125Fanconi anemia pathway_Homo sapiens_hsa034600.25659636
126RNA polymerase_Homo sapiens_hsa030200.24425914
127ECM-receptor interaction_Homo sapiens_hsa045120.24394400

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