GPC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Mutations in this gene are associated with omodysplasia 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lateral sprouting from an epithelium (GO:0060601)5.42812230
2bone trabecula formation (GO:0060346)4.88164643
3metanephric mesenchyme development (GO:0072075)4.55809961
4chondrocyte development (GO:0002063)4.51356964
5chondrocyte proliferation (GO:0035988)4.48493885
6head development (GO:0060322)4.48437893
7sequestering of extracellular ligand from receptor (GO:0035581)4.40726302
8kidney mesenchyme development (GO:0072074)4.36638380
9regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.24241270
10mesenchymal cell differentiation involved in renal system development (GO:2001012)4.09181698
11mesenchymal cell differentiation involved in kidney development (GO:0072161)4.09181698
12regulation of non-canonical Wnt signaling pathway (GO:2000050)3.95794376
13cell proliferation involved in metanephros development (GO:0072203)3.94377458
14middle ear morphogenesis (GO:0042474)3.90524070
15collagen fibril organization (GO:0030199)3.87958792
16embryonic skeletal joint morphogenesis (GO:0060272)3.86344227
17cell proliferation involved in kidney development (GO:0072111)3.77905467
18somite development (GO:0061053)3.75270556
19planar cell polarity pathway involved in neural tube closure (GO:0090179)3.65999377
20G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.62552515
21mesenchymal-epithelial cell signaling (GO:0060638)3.62434977
22regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.56764095
23craniofacial suture morphogenesis (GO:0097094)3.49013756
24mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.46162164
25embryonic cranial skeleton morphogenesis (GO:0048701)3.45404679
26neuron projection extension involved in neuron projection guidance (GO:1902284)3.42134838
27axon extension involved in axon guidance (GO:0048846)3.42134838
28extracellular regulation of signal transduction (GO:1900115)3.38253668
29extracellular negative regulation of signal transduction (GO:1900116)3.38253668
30mesenchymal cell differentiation (GO:0048762)3.34025599
31dermatan sulfate biosynthetic process (GO:0030208)3.32638825
32mesenchyme morphogenesis (GO:0072132)3.32234370
33mesonephros development (GO:0001823)3.31388142
34epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.27018525
35neural crest cell development (GO:0014032)3.23736112
36anterior/posterior axis specification, embryo (GO:0008595)3.21328409
37positive regulation of mesenchymal cell proliferation (GO:0002053)3.19775347
38regulation of mesenchymal cell proliferation (GO:0010464)3.19388330
39mesenchymal cell proliferation (GO:0010463)3.18167719
40embryonic foregut morphogenesis (GO:0048617)3.17645320
41negative regulation of chondrocyte differentiation (GO:0032331)3.16356808
42mesenchymal cell development (GO:0014031)3.14355496
43negative regulation of cartilage development (GO:0061037)3.12863860
44limb bud formation (GO:0060174)3.12824737
45negative regulation of axon extension involved in axon guidance (GO:0048843)3.11502726
46body morphogenesis (GO:0010171)3.10412705
47endocardial cushion morphogenesis (GO:0003203)3.10247642
48embryonic forelimb morphogenesis (GO:0035115)3.09893269
49dermatan sulfate metabolic process (GO:0030205)3.07511165
50regulation of glomerulus development (GO:0090192)3.06230423
51regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.03155717
52cochlea morphogenesis (GO:0090103)3.02234056
53outer ear morphogenesis (GO:0042473)3.01970524
54axonal fasciculation (GO:0007413)3.01727601
55regulation of transforming growth factor beta2 production (GO:0032909)3.01170776
56cranial nerve morphogenesis (GO:0021602)2.99821215
57cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.93849960
58cardiac epithelial to mesenchymal transition (GO:0060317)2.93156555
59glomerulus development (GO:0032835)2.92128783
60positive regulation of smoothened signaling pathway (GO:0045880)2.91357894
61glomerular filtration (GO:0003094)2.90855563
62cell differentiation involved in kidney development (GO:0061005)2.90077875
63Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.89516044
64retina vasculature morphogenesis in camera-type eye (GO:0061299)2.89435279
65forelimb morphogenesis (GO:0035136)2.88669037
66negative regulation of catenin import into nucleus (GO:0035414)2.88640404
67regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.87357036
68regulation of establishment of planar polarity (GO:0090175)2.87219931
69regulation of axon extension involved in axon guidance (GO:0048841)2.85239111
70cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.84868008
71embryonic skeletal system morphogenesis (GO:0048704)2.83483665
72camera-type eye morphogenesis (GO:0048593)2.82890161
73convergent extension (GO:0060026)2.81693069
74face morphogenesis (GO:0060325)2.81554299
75embryonic digit morphogenesis (GO:0042733)2.80870445
76bone morphogenesis (GO:0060349)2.80864795
77protein heterotrimerization (GO:0070208)2.80519112
78dorsal/ventral axis specification (GO:0009950)2.79424195
79positive regulation of cartilage development (GO:0061036)2.78986250
80smooth muscle tissue development (GO:0048745)2.78745390
81positive regulation of glomerulus development (GO:0090193)2.78123988
82regulation of cardioblast differentiation (GO:0051890)2.78030432
83regulation of chondrocyte differentiation (GO:0032330)2.77898879
84cell migration involved in heart development (GO:0060973)2.77511308
85regulation of cartilage development (GO:0061035)2.76721263
86notochord development (GO:0030903)2.76074716
87regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.76053063
88stem cell development (GO:0048864)2.75278014
89response to follicle-stimulating hormone (GO:0032354)2.74314418
90embryonic body morphogenesis (GO:0010172)2.72517291
91glomerular basement membrane development (GO:0032836)2.72415323
92negative regulation of axon guidance (GO:1902668)2.72213590
93hippo signaling (GO:0035329)2.72073632
94mesenchyme development (GO:0060485)2.71347550
95chondrocyte differentiation (GO:0002062)2.68865899
96response to BMP (GO:0071772)2.67745821
97cellular response to BMP stimulus (GO:0071773)2.67745821
98negative regulation of stem cell proliferation (GO:2000647)2.67248876
99regulation of mesonephros development (GO:0061217)2.66776838
100negative chemotaxis (GO:0050919)2.66629900
101branching involved in ureteric bud morphogenesis (GO:0001658)2.65142314
102heart morphogenesis (GO:0003007)2.64439223
103palate development (GO:0060021)2.64401190
104metanephros development (GO:0001656)2.63218192
105regulation of axon guidance (GO:1902667)2.62906567
106paraxial mesoderm development (GO:0048339)2.62530448
107radial glial cell differentiation (GO:0060019)2.60945025
108positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.60910974
109appendage morphogenesis (GO:0035107)2.60666427
110anterior/posterior axis specification (GO:0009948)2.59600254
111regulation of fibrinolysis (GO:0051917)2.56014449
112cholesterol biosynthetic process (GO:0006695)2.53112333
113reverse cholesterol transport (GO:0043691)2.50712362
114presynaptic membrane assembly (GO:0097105)2.49088965
115embryonic retina morphogenesis in camera-type eye (GO:0060059)2.48791632
116gastrulation with mouth forming second (GO:0001702)2.48100178
117regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.47719848
118kidney morphogenesis (GO:0060993)2.45591875
119primitive streak formation (GO:0090009)2.43167137
120cell migration involved in sprouting angiogenesis (GO:0002042)2.41710257
121positive regulation of male gonad development (GO:2000020)2.39995783
122regulation of gastrulation (GO:0010470)2.39316818
123ganglion development (GO:0061548)2.38920306
124COPII vesicle coating (GO:0048208)2.37969969
125artery development (GO:0060840)2.37553004
126nephron epithelium morphogenesis (GO:0072088)2.36762894
127nephron tubule morphogenesis (GO:0072078)2.36762894
128cranial suture morphogenesis (GO:0060363)2.32425827
129positive regulation of catenin import into nucleus (GO:0035413)2.28116834
130endodermal cell differentiation (GO:0035987)2.27177443
131female gonad development (GO:0008585)2.25796394
132cellular response to cholesterol (GO:0071397)2.25201364
133protein carboxylation (GO:0018214)2.24452614
134peptidyl-glutamic acid carboxylation (GO:0017187)2.24452614
135high-density lipoprotein particle remodeling (GO:0034375)2.23788251
136lung-associated mesenchyme development (GO:0060484)2.23449986
137regulation of plasminogen activation (GO:0010755)2.23291720
138embryonic digestive tract morphogenesis (GO:0048557)2.22665262
139male genitalia development (GO:0030539)2.22472500
140sterol biosynthetic process (GO:0016126)2.21432981
141positive regulation of SMAD protein import into nucleus (GO:0060391)2.19494523
142regulation of mesoderm development (GO:2000380)2.18482276
143negative regulation of activin receptor signaling pathway (GO:0032926)2.16501523
144nodal signaling pathway (GO:0038092)2.15709482
145genitalia morphogenesis (GO:0035112)2.13986466
146positive regulation of gastrulation (GO:2000543)2.13677815
147axis elongation (GO:0003401)2.13145204
148positive regulation of hormone biosynthetic process (GO:0046886)2.12635372
149organ induction (GO:0001759)2.12533745
150non-canonical Wnt signaling pathway (GO:0035567)2.11910932
151negative regulation of fibrinolysis (GO:0051918)2.10840750
152vascular smooth muscle contraction (GO:0014829)2.09919224
153positive regulation of cardiac muscle cell proliferation (GO:0060045)2.09403462
154intraciliary transport (GO:0042073)2.08308901
155prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.07063439
156substrate adhesion-dependent cell spreading (GO:0034446)2.06747429
157cholesterol efflux (GO:0033344)2.06634598
158ureteric bud development (GO:0001657)2.05750258
159regulation of protein activation cascade (GO:2000257)2.05710639
160organ formation (GO:0048645)2.05088137
161DNA strand renaturation (GO:0000733)2.03907183
162renal tubule morphogenesis (GO:0061333)2.03866259
163cell surface receptor signaling pathway involved in heart development (GO:0061311)2.03661866
164regulation of cell fate specification (GO:0042659)2.03577784

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.25015012
2EZH2_22144423_ChIP-Seq_EOC_Human3.11146000
3EED_16625203_ChIP-ChIP_MESCs_Mouse3.03937889
4GBX2_23144817_ChIP-Seq_PC3_Human2.96871244
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.75769181
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.75629190
7* EZH2_27304074_Chip-Seq_ESCs_Mouse2.70926890
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.68998460
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.64473827
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63514012
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63514012
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.50615421
13* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45950057
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42154259
15AR_21572438_ChIP-Seq_LNCaP_Human2.41548955
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39717882
17PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.39356078
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.35006964
19* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33117970
20RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.31977411
21CBX2_27304074_Chip-Seq_ESCs_Mouse2.22562659
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.13974889
23* RNF2_27304074_Chip-Seq_ESCs_Mouse2.06225308
24WT1_19549856_ChIP-ChIP_CCG9911_Human2.03360240
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.99762570
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.92659763
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.90862627
28* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87166185
29* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82808000
30ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.81855556
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.79332454
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.79223150
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.76270318
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.72741554
35* TP53_18474530_ChIP-ChIP_U2OS_Human1.71684604
36* EZH2_27294783_Chip-Seq_ESCs_Mouse1.70875662
37AR_21909140_ChIP-Seq_LNCAP_Human1.63802002
38* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61575048
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.61513034
40* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59876758
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56701413
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56254800
43* P300_19829295_ChIP-Seq_ESCs_Human1.56174345
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54656215
45* TP53_20018659_ChIP-ChIP_R1E_Mouse1.54453486
46* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53455826
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.50923654
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50473697
49EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49647988
50* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.48754915
51EP300_21415370_ChIP-Seq_HL-1_Mouse1.47741133
52* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.46860514
53* SMAD3_21741376_ChIP-Seq_EPCs_Human1.46846640
54* FUS_26573619_Chip-Seq_HEK293_Human1.46041167
55SMAD4_21799915_ChIP-Seq_A2780_Human1.45882311
56* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.45253048
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44888712
58* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.43193159
59* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.43101063
60HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42612834
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41625756
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38241842
63* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38167586
64TP53_16413492_ChIP-PET_HCT116_Human1.35923198
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35446307
66RING1B_27294783_Chip-Seq_NPCs_Mouse1.34753393
67* NANOG_16153702_ChIP-ChIP_HESCs_Human1.32984043
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32928726
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.32006877
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31956338
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30036698
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29073736
73* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28475960
74* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28139920
75* RNF2_27304074_Chip-Seq_NSC_Mouse1.27406749
76BRD4_25478319_ChIP-Seq_HGPS_Human1.27346023
77* RING1B_27294783_Chip-Seq_ESCs_Mouse1.27140361
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25449999
79* ISL1_27105846_Chip-Seq_CPCs_Mouse1.25067957
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.24211901
81* EWS_26573619_Chip-Seq_HEK293_Human1.24068448
82* CJUN_26792858_Chip-Seq_BT549_Human1.24035571
83DROSHA_22980978_ChIP-Seq_HELA_Human1.23759987
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23250401
85* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22733225
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21934436
87* ARNT_22903824_ChIP-Seq_MCF-7_Human1.21191708
88* TAF15_26573619_Chip-Seq_HEK293_Human1.20213070
89* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19419559
90* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19419559
91ZNF274_21170338_ChIP-Seq_K562_Hela1.18736227
92WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18182042
93* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17696253
94IGF1R_20145208_ChIP-Seq_DFB_Human1.17282794
95BCAT_22108803_ChIP-Seq_LS180_Human1.17156171
96PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16002423
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15558193
98SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.14349947
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13750605
100SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13612363
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13608310
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13608310
103SOX9_26525672_Chip-Seq_HEART_Mouse1.13516101
104* SMAD3_21741376_ChIP-Seq_HESCs_Human1.13489246
105* AHR_22903824_ChIP-Seq_MCF-7_Human1.11409238
106ER_23166858_ChIP-Seq_MCF-7_Human1.11181103
107NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10431832
108VDR_22108803_ChIP-Seq_LS180_Human1.09424984
109TCF4_18268006_ChIP-ChIP_LS174T_Human1.07997639
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07702358
111* AR_25329375_ChIP-Seq_VCAP_Human1.06509703
112* SMAD4_21741376_ChIP-Seq_HESCs_Human1.06345913
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06061141
114* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05539421
115SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.03818065
116* RUNX2_22187159_ChIP-Seq_PCA_Human1.03437342
117NANOG_18555785_Chip-Seq_ESCs_Mouse1.02724575
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02671920
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02413784
120TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01742458
121ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01609145
122* STAT3_23295773_ChIP-Seq_U87_Human1.00626381
123* AR_19668381_ChIP-Seq_PC3_Human0.99794655
124TCF4_22108803_ChIP-Seq_LS180_Human0.99285714
125FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99029542
126SMAD4_21741376_ChIP-Seq_EPCs_Human0.98641131
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97013497
128* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96902262
129* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96794925
130* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96484438
131NFE2_27457419_Chip-Seq_LIVER_Mouse0.95661964
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94604831
133CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93535206
134SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.93396193
135* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93332601
136* SOX2_16153702_ChIP-ChIP_HESCs_Human0.92362539
137P53_22387025_ChIP-Seq_ESCs_Mouse0.92340991

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology4.92077267
2MP0008438_abnormal_cutaneous_collagen3.82358553
3MP0009250_abnormal_appendicular_skeleto3.17808224
4MP0003122_maternal_imprinting2.89152875
5MP0003385_abnormal_body_wall2.88527973
6MP0000049_abnormal_middle_ear2.85545678
7MP0009384_cardiac_valve_regurgitation2.80383265
8MP0002249_abnormal_larynx_morphology2.76141901
9MP0005275_abnormal_skin_tensile2.61660064
10MP0010030_abnormal_orbit_morphology2.61424837
11MP0000566_synostosis2.52136390
12MP0003942_abnormal_urinary_system2.41630889
13MP0004272_abnormal_basement_membrane2.29075100
14MP0003890_abnormal_embryonic-extraembry2.26313278
15MP0003937_abnormal_limbs/digits/tail_de2.23969516
16MP0002282_abnormal_trachea_morphology2.13836944
17MP0004134_abnormal_chest_morphology2.12680873
18MP0005508_abnormal_skeleton_morphology2.11497157
19MP0003279_aneurysm2.09913326
20MP0009053_abnormal_anal_canal2.08937670
21MP0003755_abnormal_palate_morphology2.05561006
22MP0000534_abnormal_ureter_morphology2.04100495
23MP0002938_white_spotting2.03640435
24MP0002254_reproductive_system_inflammat1.90601719
25MP0002108_abnormal_muscle_morphology1.90311421
26MP0000762_abnormal_tongue_morphology1.88233942
27MP0003938_abnormal_ear_development1.82405806
28MP0005623_abnormal_meninges_morphology1.77010124
29MP0003941_abnormal_skin_development1.76321686
30MP0000163_abnormal_cartilage_morphology1.72589621
31MP0002932_abnormal_joint_morphology1.72171461
32MP0003121_genomic_imprinting1.65802318
33MP0000428_abnormal_craniofacial_morphol1.63399722
34MP0003935_abnormal_craniofacial_develop1.62180553
35MP0005248_abnormal_Harderian_gland1.61352945
36MP0002116_abnormal_craniofacial_bone1.61248414
37MP0001299_abnormal_eye_distance/1.61230702
38MP0003283_abnormal_digestive_organ1.60067551
39MP0002233_abnormal_nose_morphology1.59896686
40MP0002109_abnormal_limb_morphology1.59339102
41MP0001958_emphysema1.56930703
42MP0000537_abnormal_urethra_morphology1.47847407
43MP0003123_paternal_imprinting1.46950439
44MP0005257_abnormal_intraocular_pressure1.46785461
45MP0002115_abnormal_skeleton_extremities1.46119666
46MP0000432_abnormal_head_morphology1.45848808
47MP0004133_heterotaxia1.40623928
48MP0005171_absent_coat_pigmentation1.39563842
49MP0001270_distended_abdomen1.35793880
50MP0003195_calcinosis1.35296665
51MP0002896_abnormal_bone_mineralization1.29028480
52MP0002139_abnormal_hepatobiliary_system1.28399926
53MP0002177_abnormal_outer_ear1.27905819
54MP0002113_abnormal_skeleton_development1.27470116
55MP0009780_abnormal_chondrocyte_physiolo1.23233206
56MP0000516_abnormal_urinary_system1.19277340
57MP0005367_renal/urinary_system_phenotyp1.19277340
58MP0003115_abnormal_respiratory_system1.17137546
59MP0003567_abnormal_fetal_cardiomyocyte1.16412778
60MP0001346_abnormal_lacrimal_gland1.13496361
61MP0002295_abnormal_pulmonary_circulatio1.11947153
62MP0002114_abnormal_axial_skeleton1.09370474
63MP0000639_abnormal_adrenal_gland1.09236558
64MP0001286_abnormal_eye_development1.08624169
65MP0010368_abnormal_lymphatic_system1.07773030
66MP0003136_yellow_coat_color1.07604645
67MP0001293_anophthalmia1.04396075
68MP0001340_abnormal_eyelid_morphology1.03942685
69MP0002102_abnormal_ear_morphology1.02885303
70MP0002092_abnormal_eye_morphology1.02117351
71MP0002084_abnormal_developmental_patter1.01888708
72MP0005409_darkened_coat_color1.00814435
73MP0001879_abnormal_lymphatic_vessel1.00409690
74MP0000631_abnormal_neuroendocrine_gland1.00295554
75MP0006292_abnormal_olfactory_placode0.98146101
76MP0000767_abnormal_smooth_muscle0.97304626
77MP0000026_abnormal_inner_ear0.97031473
78MP0003705_abnormal_hypodermis_morpholog0.96486092
79MP0002751_abnormal_autonomic_nervous0.96433310
80MP0002111_abnormal_tail_morphology0.94053840
81MP0005408_hypopigmentation0.93949783
82MP0001915_intracranial_hemorrhage0.93893187
83MP0000733_abnormal_muscle_development0.93890426
84MP0009697_abnormal_copulation0.93412014
85MP0004145_abnormal_muscle_electrophysio0.92491615
86MP0000462_abnormal_digestive_system0.91289466
87MP0000678_abnormal_parathyroid_gland0.91172442
88MP0000778_abnormal_nervous_system0.90524078
89MP0003868_abnormal_feces_composition0.90101341
90MP0003119_abnormal_digestive_system0.87859104
91MP0000613_abnormal_salivary_gland0.87727071
92MP0005390_skeleton_phenotype0.87199012
93MP0001529_abnormal_vocalization0.86391334
94MP0001666_abnormal_nutrient_absorption0.85963222
95MP0002933_joint_inflammation0.84944383
96MP0002085_abnormal_embryonic_tissue0.84730803
97MP0001188_hyperpigmentation0.82777903
98MP0003011_delayed_dark_adaptation0.82239193
99MP0005085_abnormal_gallbladder_physiolo0.81167529
100MP0002089_abnormal_postnatal_growth/wei0.80697445
101MP0006072_abnormal_retinal_apoptosis0.80328600
102MP0001661_extended_life_span0.80323777
103MP0005595_abnormal_vascular_smooth0.79387288
104MP0010329_abnormal_lipoprotein_level0.79320216
105MP0003861_abnormal_nervous_system0.78329098
106MP0008789_abnormal_olfactory_epithelium0.77813808
107MP0002234_abnormal_pharynx_morphology0.77771930
108MP0005391_vision/eye_phenotype0.77609978
109MP0001177_atelectasis0.76728355
110MP0000647_abnormal_sebaceous_gland0.75906082
111MP0002697_abnormal_eye_size0.75382847
112MP0000569_abnormal_digit_pigmentation0.74628355
113MP0003787_abnormal_imprinting0.72804883
114MP0002127_abnormal_cardiovascular_syste0.72801130
115MP0003566_abnormal_cell_adhesion0.72460880
116MP0001175_abnormal_lung_morphology0.71419513
117MP0000751_myopathy0.71246520
118MP0002081_perinatal_lethality0.70747305
119MP0003315_abnormal_perineum_morphology0.70699569
120MP0000579_abnormal_nail_morphology0.69916959
121MP0008932_abnormal_embryonic_tissue0.69597545
122MP0002060_abnormal_skin_morphology0.69076399
123MP0006138_congestive_heart_failure0.65401066
124MP0006054_spinal_hemorrhage0.65232883
125MP0004484_altered_response_of0.64885552
126MP0009703_decreased_birth_body0.64587093
127MP0005187_abnormal_penis_morphology0.64074936
128MP0005388_respiratory_system_phenotype0.62841231
129MP0002133_abnormal_respiratory_system0.62841231
130MP0002184_abnormal_innervation0.62539058
131MP0005197_abnormal_uvea_morphology0.62106424

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)4.47364856
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.47364856
3Protrusio acetabuli (HP:0003179)3.72499072
4Premature rupture of membranes (HP:0001788)3.41327826
5Morphological abnormality of the middle ear (HP:0008609)3.38026598
6Abnormality of the nasal septum (HP:0000419)3.31791355
7Abnormality of the 4th metacarpal (HP:0010012)3.30016009
8Shallow orbits (HP:0000586)3.26042704
9Broad metatarsal (HP:0001783)3.11848025
10Neonatal short-limb short stature (HP:0008921)3.00948315
11Microglossia (HP:0000171)2.98700365
12Vitreoretinal degeneration (HP:0000655)2.87892024
13Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.86599980
14Hepatoblastoma (HP:0002884)2.80300787
15Cutaneous finger syndactyly (HP:0010554)2.78596797
16Bifid tongue (HP:0010297)2.77785518
17Hypoplastic ischia (HP:0003175)2.74814867
18Epiphyseal dysplasia (HP:0002656)2.73789759
19Abnormality of the middle phalanges of the toes (HP:0010183)2.73481977
20Abnormality of the phalanges of the 2nd finger (HP:0009541)2.71720095
21Asymmetry of the thorax (HP:0001555)2.69561509
22Broad toe (HP:0001837)2.66633336
23Midline defect of the nose (HP:0004122)2.58393546
24Abnormality of the parietal bone (HP:0002696)2.55918756
25Bell-shaped thorax (HP:0001591)2.47903560
26Aortic dissection (HP:0002647)2.46567117
27Abnormality of the phalanges of the 5th finger (HP:0004213)2.45866698
28Short hallux (HP:0010109)2.44276701
29Humeroradial synostosis (HP:0003041)2.39651022
30Synostosis involving the elbow (HP:0003938)2.39651022
31Arterial tortuosity (HP:0005116)2.39488199
32Abnormality of the proximal phalanges of the hand (HP:0009834)2.38841508
33Abnormality of the ischium (HP:0003174)2.38048979
34Mesomelia (HP:0003027)2.37773621
35Aplasia involving bones of the upper limbs (HP:0009823)2.37398790
36Aplasia of the phalanges of the hand (HP:0009802)2.37398790
37Aplasia involving bones of the extremities (HP:0009825)2.37398790
38Cutaneous syndactyly (HP:0012725)2.37278358
39Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.35755427
40Broad hallux (HP:0010055)2.34768379
41Coronal craniosynostosis (HP:0004440)2.34194085
42Soft skin (HP:0000977)2.32076102
43Wide anterior fontanel (HP:0000260)2.25897381
44Abnormality of incisor morphology (HP:0011063)2.25593487
45Broad ribs (HP:0000885)2.23381282
46Broad long bones (HP:0005622)2.21678165
47Abnormality of the nasolacrimal system (HP:0000614)2.21279266
48Broad thumb (HP:0011304)2.20158912
49Abnormality of the pubic bones (HP:0003172)2.18782115
50Aortic aneurysm (HP:0004942)2.17785941
51Tracheomalacia (HP:0002779)2.17220680
52Spinal cord lesions (HP:0100561)2.14496669
53Syringomyelia (HP:0003396)2.14496669
54Aplasia/Hypoplasia of the hallux (HP:0008362)2.13628940
55Arthropathy (HP:0003040)2.12213028
56Abnormality of dentin (HP:0010299)2.12009266
57Broad phalanx (HP:0006009)2.11455095
58Long nose (HP:0003189)2.11150654
59Mitral stenosis (HP:0001718)2.10391237
60Abnormality of the lacrimal duct (HP:0011481)2.08776128
61Myelomeningocele (HP:0002475)2.08288594
62Septo-optic dysplasia (HP:0100842)2.07863836
63Overgrowth (HP:0001548)2.07665608
64Nasolacrimal duct obstruction (HP:0000579)2.06730781
65Mild short stature (HP:0003502)2.03892382
66Bladder diverticulum (HP:0000015)2.03312725
67Broad finger (HP:0001500)2.01511755
68Abnormal tarsal ossification (HP:0008369)2.01354603
69Follicular hyperkeratosis (HP:0007502)2.01276186
70Intestinal atresia (HP:0011100)2.00490204
71Abnormality of the 2nd finger (HP:0004100)2.00477405
72Prolonged partial thromboplastin time (HP:0003645)1.99746730
73Supernumerary spleens (HP:0009799)1.99688127
74Hip contracture (HP:0003273)1.99141139
75Absent frontal sinuses (HP:0002688)1.98133285
76Abnormality of the phalanges of the hallux (HP:0010057)1.96688405
77Vascular tortuosity (HP:0004948)1.96032848
78Broad phalanges of the hand (HP:0009768)1.95674352
79Abnormality of the middle phalanges of the hand (HP:0009833)1.94784970
80Preaxial foot polydactyly (HP:0001841)1.94578512
81Trigonocephaly (HP:0000243)1.92595338
82Ankle contracture (HP:0006466)1.92284011
83Increased number of teeth (HP:0011069)1.91903990
84* Limited hip movement (HP:0008800)1.91141562
85Abnormality of carpal bone ossification (HP:0006257)1.90034334
86Renal hypoplasia (HP:0000089)1.89640434
87Abnormal delivery (HP:0001787)1.89272523
88Supernumerary ribs (HP:0005815)1.89147061
89Metaphyseal dysplasia (HP:0100255)1.89105152
90Short clavicles (HP:0000894)1.88499940
91Atrophic scars (HP:0001075)1.87401561
92Lip pit (HP:0100267)1.85755890
93Abnormal lung lobation (HP:0002101)1.83885909
94Hypobetalipoproteinemia (HP:0003563)1.83746181
95Fibular aplasia (HP:0002990)1.83597937
96Genital tract atresia (HP:0001827)1.81425078
97Joint laxity (HP:0001388)1.81344742
98Osteoarthritis (HP:0002758)1.81190034
99Aplasia/Hypoplasia of the clavicles (HP:0006710)1.80864498
100Synostosis of carpal bones (HP:0005048)1.80858377
101Abnormality of the incisor (HP:0000676)1.79928970
102Small epiphyses (HP:0010585)1.77739333
103Cervical subluxation (HP:0003308)1.77472316
104Vaginal atresia (HP:0000148)1.77374139
105Wormian bones (HP:0002645)1.76715836
106Anophthalmia (HP:0000528)1.76626702
107Embryonal renal neoplasm (HP:0011794)1.76245394
108Irregular epiphyses (HP:0010582)1.76035440
109Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.75813505
110Delayed cranial suture closure (HP:0000270)1.75749924
111Absent eyebrow (HP:0002223)1.75513666
112Spondylolisthesis (HP:0003302)1.74641242
113Deep venous thrombosis (HP:0002625)1.74558351
114Abnormal umbilical cord blood vessels (HP:0011403)1.74555837
115Single umbilical artery (HP:0001195)1.74555837
116Abnormality of the fetal cardiovascular system (HP:0010948)1.74555837
117Infantile muscular hypotonia (HP:0008947)1.74387612
118Diastasis recti (HP:0001540)1.74308062
119Renal duplication (HP:0000075)1.74219707
120Omphalocele (HP:0001539)1.73687763
121Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.73122535
122Abnormality of the distal phalanx of the thumb (HP:0009617)1.73103134
123Hypolipoproteinemia (HP:0010981)1.73075622
124Hypoplasia of the maxilla (HP:0000327)1.72499555
125Short middle phalanx of the 5th finger (HP:0004220)1.72411409
126Keratoconus (HP:0000563)1.71141626
127Increased corneal curvature (HP:0100692)1.71141626
128Broad palm (HP:0001169)1.69998623
129Hyperglycinemia (HP:0002154)1.67022552
130Vertebral clefting (HP:0008428)1.65296214
131Hypoalphalipoproteinemia (HP:0003233)1.65259049
132Hypoplastic pelvis (HP:0008839)1.65201962
133Abnormal hand bone ossification (HP:0010660)1.64095158
134Choanal stenosis (HP:0000452)1.61931739
135Bilateral microphthalmos (HP:0007633)1.59489356
136Pulmonic stenosis (HP:0001642)1.58925943
137Partial duplication of the phalanx of hand (HP:0009999)1.57946812
138Abnormal foot bone ossification (HP:0010675)1.57298750
139Short middle phalanx of finger (HP:0005819)1.57003515
140Ulnar bowing (HP:0003031)1.56055832
141Mitral valve prolapse (HP:0001634)1.53764916
142Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.53226020
143Absent epiphyses (HP:0010577)1.53226020
144Abnormality of the aortic arch (HP:0012303)1.52982165
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.52656677
146Blue sclerae (HP:0000592)1.50518129
147Proximal tubulopathy (HP:0000114)1.49804111
148Cupped ribs (HP:0000887)1.49706799
149Abnormal ossification of hand bones (HP:0005921)1.48059835
150Occipital encephalocele (HP:0002085)1.46103270
151Alacrima (HP:0000522)1.45556947
152Broad alveolar ridges (HP:0000187)1.45527359
153Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.45158025
154Colon cancer (HP:0003003)1.44883167
155Arnold-Chiari malformation (HP:0002308)1.44299806
156Abnormal connection of the cardiac segments (HP:0011545)1.44250433
157Abnormal ventriculo-arterial connection (HP:0011563)1.44250433
158Transposition of the great arteries (HP:0001669)1.44250433
159Bicornuate uterus (HP:0000813)1.44169143
160Postaxial hand polydactyly (HP:0001162)1.44146487

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA35.98871664
2DDR24.22292059
3LATS14.14876387
4CASK3.28919154
5EPHB22.72058312
6INSRR2.59803396
7NUAK12.56513142
8WNK32.38712612
9SIK12.11774896
10MKNK22.11614055
11DMPK1.96504367
12EPHA41.93036621
13CAMK1G1.83361287
14PDGFRA1.80231468
15NEK11.69724349
16NEK91.67734075
17LATS21.67324391
18TTK1.64775574
19MKNK11.63383317
20WEE11.61211414
21MAP4K21.53776124
22TRIM281.51187257
23STK38L1.41577624
24PIK3CA1.40077609
25ACVR1B1.39401880
26STK31.39193278
27PLK41.39158983
28TNIK1.38334269
29NTRK31.34112577
30PLK21.33672503
31CAMK1D1.32579870
32WNK11.32233351
33ZAK1.29316967
34BRSK21.27570973
35EIF2AK31.25286340
36FGFR21.21502348
37ERBB31.19088497
38MAP3K121.18807940
39NLK1.16104263
40BMPR1B1.13088660
41FGFR11.13010645
42FLT31.11926189
43FER1.11708918
44CLK11.10886278
45AKT31.10283958
46PRPF4B1.08288613
47PAK31.04966532
48EIF2AK21.03281469
49FGFR41.03035959
50MAPK131.02159960
51PTK21.02080044
52NEK20.97919996
53ROCK10.96754095
54PAK20.94438182
55CDK30.94413390
56MAP3K40.94394224
57PKN10.94027870
58FRK0.93045606
59PNCK0.91548466
60TTN0.91240677
61STK160.91011315
62TGFBR10.90665535
63GRK10.86880959
64TSSK60.86830547
65STK390.86760507
66BCR0.85446846
67PRKCE0.84547588
68ERBB20.83434171
69NEK60.83260131
70MELK0.82813184
71MET0.82731604
72PKN20.82489098
73TAOK20.80530010
74LIMK10.79626822
75ROCK20.78198091
76TAF10.77072479
77FGFR30.76677650
78BUB10.76531253
79PLK10.75329510
80CDC42BPA0.75235858
81CSNK1A1L0.74884287
82PDGFRB0.74342453
83PRKD20.73757056
84SRPK10.72494442
85ADRBK10.71144334
86EIF2AK10.65904066
87VRK10.65372593
88CDK80.64510431
89MAP3K100.64425115
90MUSK0.63438752
91CSNK1G20.59272032
92BRD40.58451952
93PHKG20.57561643
94PHKG10.57561643
95PRKG10.57251358
96PAK40.57169519
97PRKAA20.56828068
98KSR10.55417887
99BMX0.55210943
100DYRK30.54802861
101CSNK1G10.53505389
102PLK30.52915015
103ATM0.52602828
104CSNK1G30.51791660
105PTK2B0.51708503
106CAMK2A0.50927929
107DYRK1A0.49682043
108NTRK20.47501608
109INSR0.46571340
110NTRK10.46551627
111STK240.46277579
112PRKD30.46266275
113CDK120.44935533
114IRAK10.44584533
115BRSK10.44248596
116YES10.44003889
117MYLK0.43812492
118ICK0.43683894
119DYRK20.43208680
120GSK3A0.42871978
121STK380.42133328
122TYRO30.41665039
123CAMK2D0.41495935
124PBK0.41403071
125CAMK40.40405561
126TRPM70.40167319
127ERBB40.39596009
128PRKD10.37881140
129SGK20.37725035
130WNK40.37676969
131PRKCH0.37078789
132CAMK10.37051680
133IGF1R0.36494242
134ADRBK20.36203867
135SIK30.35986522
136MAPK70.35643884
137TGFBR20.35352874
138PRKCG0.34406559
139MTOR0.34026717
140SRC0.33417108
141CDK70.32585214
142SGK10.32397406
143MAPK100.30808064

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.02607004
2Basal cell carcinoma_Homo sapiens_hsa052173.00453503
3Steroid biosynthesis_Homo sapiens_hsa001002.95276362
4Hedgehog signaling pathway_Homo sapiens_hsa043402.54324626
5Axon guidance_Homo sapiens_hsa043602.35101697
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.33050861
7Propanoate metabolism_Homo sapiens_hsa006402.18978315
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.16919378
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.10396774
10Protein digestion and absorption_Homo sapiens_hsa049742.08600763
11Complement and coagulation cascades_Homo sapiens_hsa046102.03909833
12TGF-beta signaling pathway_Homo sapiens_hsa043502.03447750
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.01465813
14Wnt signaling pathway_Homo sapiens_hsa043102.01262985
15Protein export_Homo sapiens_hsa030601.99491702
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.95247021
17Dilated cardiomyopathy_Homo sapiens_hsa054141.92295286
18Focal adhesion_Homo sapiens_hsa045101.91340814
19Hippo signaling pathway_Homo sapiens_hsa043901.91190386
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.81918348
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.81410812
22Nicotine addiction_Homo sapiens_hsa050331.79873383
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.79443988
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78042047
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67479086
26Vitamin B6 metabolism_Homo sapiens_hsa007501.63823651
27Adherens junction_Homo sapiens_hsa045201.59994783
28Melanoma_Homo sapiens_hsa052181.58400683
29Melanogenesis_Homo sapiens_hsa049161.56249440
30Proteoglycans in cancer_Homo sapiens_hsa052051.55434227
31MicroRNAs in cancer_Homo sapiens_hsa052061.51065826
32Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.47577714
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.46894747
34Phototransduction_Homo sapiens_hsa047441.42304075
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41549613
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.38011871
37PI3K-Akt signaling pathway_Homo sapiens_hsa041511.34706764
38Butanoate metabolism_Homo sapiens_hsa006501.33680106
39Fatty acid metabolism_Homo sapiens_hsa012121.31076817
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.30428824
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.29782827
42Fatty acid degradation_Homo sapiens_hsa000711.28353004
43Circadian entrainment_Homo sapiens_hsa047131.28333027
44Fat digestion and absorption_Homo sapiens_hsa049751.27630129
45Cocaine addiction_Homo sapiens_hsa050301.27625641
46Renin secretion_Homo sapiens_hsa049241.27316724
47Fatty acid elongation_Homo sapiens_hsa000621.27221394
48Prostate cancer_Homo sapiens_hsa052151.26472509
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.22743715
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21336039
51Morphine addiction_Homo sapiens_hsa050321.20529126
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20424012
53Glutamatergic synapse_Homo sapiens_hsa047241.20378981
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.20231798
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19343454
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18914943
57cAMP signaling pathway_Homo sapiens_hsa040241.18752266
58Retinol metabolism_Homo sapiens_hsa008301.18108564
59Rap1 signaling pathway_Homo sapiens_hsa040151.17440512
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17347346
61Salivary secretion_Homo sapiens_hsa049701.17331362
62Pathways in cancer_Homo sapiens_hsa052001.15255052
63Long-term depression_Homo sapiens_hsa047301.15208481
64Steroid hormone biosynthesis_Homo sapiens_hsa001401.12723230
65Pyruvate metabolism_Homo sapiens_hsa006201.12129067
66Vascular smooth muscle contraction_Homo sapiens_hsa042701.11822861
67Gap junction_Homo sapiens_hsa045401.10776281
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10461693
69Malaria_Homo sapiens_hsa051441.09620011
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09581488
71GABAergic synapse_Homo sapiens_hsa047271.08107587
72Calcium signaling pathway_Homo sapiens_hsa040201.07803716
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07238440
74Non-homologous end-joining_Homo sapiens_hsa034501.05380861
75Taste transduction_Homo sapiens_hsa047421.05065870
76Amphetamine addiction_Homo sapiens_hsa050311.03206312
77Vitamin digestion and absorption_Homo sapiens_hsa049771.02914411
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02914294
79Serotonergic synapse_Homo sapiens_hsa047261.01267404
80Selenocompound metabolism_Homo sapiens_hsa004501.01264968
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00686974
82N-Glycan biosynthesis_Homo sapiens_hsa005101.00393937
83Amoebiasis_Homo sapiens_hsa051460.98377543
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97946905
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97863512
86Chemical carcinogenesis_Homo sapiens_hsa052040.97723909
87Ovarian steroidogenesis_Homo sapiens_hsa049130.96611010
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96450087
89Ras signaling pathway_Homo sapiens_hsa040140.96146283
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.95825390
91One carbon pool by folate_Homo sapiens_hsa006700.90688388
92Oxytocin signaling pathway_Homo sapiens_hsa049210.90356296
93Cholinergic synapse_Homo sapiens_hsa047250.90162571
94Dorso-ventral axis formation_Homo sapiens_hsa043200.88098774
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87679190
96Small cell lung cancer_Homo sapiens_hsa052220.87666366
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86232813
98Insulin secretion_Homo sapiens_hsa049110.85661340
99Arginine biosynthesis_Homo sapiens_hsa002200.85054177
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83037049
101Glioma_Homo sapiens_hsa052140.81312756
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80293293
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79132102
104Tryptophan metabolism_Homo sapiens_hsa003800.78961146
105PPAR signaling pathway_Homo sapiens_hsa033200.78915380
106Gastric acid secretion_Homo sapiens_hsa049710.78168580
107Tight junction_Homo sapiens_hsa045300.77595340
108Glutathione metabolism_Homo sapiens_hsa004800.77413413
109MAPK signaling pathway_Homo sapiens_hsa040100.77180491
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75930222
111Fanconi anemia pathway_Homo sapiens_hsa034600.74546355
112Olfactory transduction_Homo sapiens_hsa047400.74303658
113Dopaminergic synapse_Homo sapiens_hsa047280.73819595
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73218096
115Basal transcription factors_Homo sapiens_hsa030220.71628226
116Arginine and proline metabolism_Homo sapiens_hsa003300.71324264
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70361712
118Peroxisome_Homo sapiens_hsa041460.69600169
119Starch and sucrose metabolism_Homo sapiens_hsa005000.69526679
120Histidine metabolism_Homo sapiens_hsa003400.68587503
121Sulfur metabolism_Homo sapiens_hsa009200.68033114
122Renal cell carcinoma_Homo sapiens_hsa052110.67970072
123GnRH signaling pathway_Homo sapiens_hsa049120.67945969
124Biosynthesis of amino acids_Homo sapiens_hsa012300.67169183
125Nitrogen metabolism_Homo sapiens_hsa009100.65519346
126ErbB signaling pathway_Homo sapiens_hsa040120.64290211
127Estrogen signaling pathway_Homo sapiens_hsa049150.63871254
128Cell cycle_Homo sapiens_hsa041100.63141579
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62950658
130Colorectal cancer_Homo sapiens_hsa052100.62674425
131Lysine degradation_Homo sapiens_hsa003100.62666926
132Carbon metabolism_Homo sapiens_hsa012000.62497742
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.62364262
134Thyroid hormone synthesis_Homo sapiens_hsa049180.61932131
135Viral myocarditis_Homo sapiens_hsa054160.61565469
136Notch signaling pathway_Homo sapiens_hsa043300.60781144
137p53 signaling pathway_Homo sapiens_hsa041150.60778379
138Long-term potentiation_Homo sapiens_hsa047200.60734860
139Folate biosynthesis_Homo sapiens_hsa007900.60179538
140Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59196460
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59096726
142Choline metabolism in cancer_Homo sapiens_hsa052310.57184839
143beta-Alanine metabolism_Homo sapiens_hsa004100.56719329
144Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56544780
145Mismatch repair_Homo sapiens_hsa034300.56262893
146Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56145141
147Tyrosine metabolism_Homo sapiens_hsa003500.55006900
148Circadian rhythm_Homo sapiens_hsa047100.54638339
149Caffeine metabolism_Homo sapiens_hsa002320.54206732
150Type II diabetes mellitus_Homo sapiens_hsa049300.53083338
151Renin-angiotensin system_Homo sapiens_hsa046140.52523721
152HTLV-I infection_Homo sapiens_hsa051660.51087523
153Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50425196
154Nucleotide excision repair_Homo sapiens_hsa034200.50235916
155Bile secretion_Homo sapiens_hsa049760.48907323
156Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48384597
157Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48378358
158Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48170377
159Metabolic pathways_Homo sapiens_hsa011000.47812076
160Platelet activation_Homo sapiens_hsa046110.47582107
161Mineral absorption_Homo sapiens_hsa049780.47146859
162African trypanosomiasis_Homo sapiens_hsa051430.46776702
163Cardiac muscle contraction_Homo sapiens_hsa042600.45599112
164Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45238143
165Sphingolipid metabolism_Homo sapiens_hsa006000.44793128
166Pancreatic secretion_Homo sapiens_hsa049720.44524360
167Fatty acid biosynthesis_Homo sapiens_hsa000610.43666447
168Bladder cancer_Homo sapiens_hsa052190.43296154
169Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42468346
170Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42047432
171Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40484681

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