GPD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sequestering of triglyceride (GO:0010889)6.07190204
2diacylglycerol metabolic process (GO:0046339)5.87914816
3alpha-linolenic acid metabolic process (GO:0036109)5.51907849
4fatty acid transmembrane transport (GO:1902001)5.43302525
5fatty acid beta-oxidation (GO:0006635)5.38535107
6carnitine shuttle (GO:0006853)5.31299359
7biotin metabolic process (GO:0006768)5.28793326
8L-phenylalanine catabolic process (GO:0006559)5.13205813
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.13205813
10transcytosis (GO:0045056)5.09344459
11regulation of triglyceride catabolic process (GO:0010896)5.07927256
12acetyl-CoA metabolic process (GO:0006084)4.97012196
13valine metabolic process (GO:0006573)4.96143898
14lysine metabolic process (GO:0006553)4.95960626
15lysine catabolic process (GO:0006554)4.95960626
16lipid storage (GO:0019915)4.95154099
17L-phenylalanine metabolic process (GO:0006558)4.95026773
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.95026773
19fatty acid oxidation (GO:0019395)4.91242078
20low-density lipoprotein particle clearance (GO:0034383)4.89709419
21positive regulation of fatty acid beta-oxidation (GO:0032000)4.88558461
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.85503062
23fatty acid catabolic process (GO:0009062)4.84619148
24lipid oxidation (GO:0034440)4.82464943
25triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.76439555
26triglyceride catabolic process (GO:0019433)4.68429755
27oxaloacetate metabolic process (GO:0006107)4.68140197
28positive regulation of fatty acid oxidation (GO:0046321)4.63412440
29acylglycerol catabolic process (GO:0046464)4.51028347
30neutral lipid catabolic process (GO:0046461)4.51028347
31branched-chain amino acid catabolic process (GO:0009083)4.49459357
32lipid particle organization (GO:0034389)4.47250723
33short-chain fatty acid metabolic process (GO:0046459)4.43221539
34sulfur amino acid catabolic process (GO:0000098)4.36780919
35positive regulation of lipid storage (GO:0010884)4.36103863
36regulation of fatty acid oxidation (GO:0046320)4.32576785
37positive regulation of lipid catabolic process (GO:0050996)4.31093720
38branched-chain amino acid metabolic process (GO:0009081)4.29726195
39carnitine transmembrane transport (GO:1902603)4.29399508
40amino-acid betaine metabolic process (GO:0006577)4.28549830
41aromatic amino acid family catabolic process (GO:0009074)4.27935577
42monocarboxylic acid catabolic process (GO:0072329)4.27883290
43acyl-CoA biosynthetic process (GO:0071616)4.26596451
44thioester biosynthetic process (GO:0035384)4.26596451
45carnitine transport (GO:0015879)4.24743361
46amino-acid betaine transport (GO:0015838)4.24743361
47plasma lipoprotein particle clearance (GO:0034381)4.20049309
48response to dietary excess (GO:0002021)4.17831894
49triglyceride homeostasis (GO:0070328)4.14282223
50acylglycerol homeostasis (GO:0055090)4.14282223
51fatty-acyl-CoA biosynthetic process (GO:0046949)4.11865560
52glyoxylate metabolic process (GO:0046487)4.11551050
53cysteine metabolic process (GO:0006534)4.09550633
54positive regulation of lipoprotein lipase activity (GO:0051006)4.08556640
55positive regulation of triglyceride lipase activity (GO:0061365)4.08556640
56creatine metabolic process (GO:0006600)4.07580991
57regulation of fatty acid beta-oxidation (GO:0031998)4.03293797
58ethanol metabolic process (GO:0006067)3.98758918
59carnitine metabolic process (GO:0009437)3.98089993
60regulation of glycogen (starch) synthase activity (GO:2000465)3.97716209
61polyol transport (GO:0015791)3.94737561
62regulation of cAMP-dependent protein kinase activity (GO:2000479)3.93653157
63tricarboxylic acid cycle (GO:0006099)3.93382247
642-oxoglutarate metabolic process (GO:0006103)3.92807703
65negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.92583930
66white fat cell differentiation (GO:0050872)3.91940083
67bile acid biosynthetic process (GO:0006699)3.90509897
68cellular response to epinephrine stimulus (GO:0071872)3.88451874
69complement activation, alternative pathway (GO:0006957)3.87967604
70tricarboxylic acid metabolic process (GO:0072350)3.84117753
71fatty-acyl-CoA metabolic process (GO:0035337)3.81769461
72positive regulation of cholesterol efflux (GO:0010875)3.79504796
73CDP-diacylglycerol biosynthetic process (GO:0016024)3.79124072
74urea cycle (GO:0000050)3.78748248
75urea metabolic process (GO:0019627)3.78748248
76brown fat cell differentiation (GO:0050873)3.76934144
77primary alcohol metabolic process (GO:0034308)3.75367707
78response to phenylpropanoid (GO:0080184)3.75280884
79thioester metabolic process (GO:0035383)3.71779101
80acyl-CoA metabolic process (GO:0006637)3.71779101
81glycerol metabolic process (GO:0006071)3.71505653
82aspartate family amino acid catabolic process (GO:0009068)3.70021083
83long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.69135409
84protein heterotrimerization (GO:0070208)3.68152817
85positive regulation of triglyceride metabolic process (GO:0090208)3.65764388
86* triglyceride biosynthetic process (GO:0019432)3.65180703
87regulation of cholesterol storage (GO:0010885)3.63745215
88cellular ketone body metabolic process (GO:0046950)3.63391241
89CDP-diacylglycerol metabolic process (GO:0046341)3.63036674
90quaternary ammonium group transport (GO:0015697)3.62934221
91succinate metabolic process (GO:0006105)3.62240546
92positive regulation of glomerulus development (GO:0090193)3.62068795
93organic acid catabolic process (GO:0016054)3.61996118
94carboxylic acid catabolic process (GO:0046395)3.61996118
95negative regulation of granulocyte differentiation (GO:0030853)3.61205620
96negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.60953385
97homocysteine metabolic process (GO:0050667)3.56747403
98* acylglycerol biosynthetic process (GO:0046463)3.56305041
99* neutral lipid biosynthetic process (GO:0046460)3.56305041
100regulation of triglyceride metabolic process (GO:0090207)3.55505906
101positive regulation of fatty acid metabolic process (GO:0045923)3.55484578
102negative regulation of lipase activity (GO:0060192)3.55309221
103indolalkylamine catabolic process (GO:0046218)3.54913089
104tryptophan catabolic process (GO:0006569)3.54913089
105indole-containing compound catabolic process (GO:0042436)3.54913089
106serine family amino acid catabolic process (GO:0009071)3.54407128
107* triglyceride metabolic process (GO:0006641)3.54301352
108kynurenine metabolic process (GO:0070189)3.53675909
109nitrogen cycle metabolic process (GO:0071941)3.52888873
110regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.52313782
111alpha-amino acid catabolic process (GO:1901606)3.49319220
112ethanol oxidation (GO:0006069)3.46901346
113glycogen catabolic process (GO:0005980)3.46218805
114cellular amino acid catabolic process (GO:0009063)3.44958215
115positive regulation of cholesterol transport (GO:0032376)3.43763320
116positive regulation of sterol transport (GO:0032373)3.43763320
117regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.43619017
118regulation of macrophage derived foam cell differentiation (GO:0010743)3.42819826
119bile acid metabolic process (GO:0008206)3.41327916
120response to epinephrine (GO:0071871)3.40481186
121regulation of lipoprotein metabolic process (GO:0050746)3.39738588
122glucan catabolic process (GO:0009251)3.39033474
123regulation of cholesterol metabolic process (GO:0090181)3.39028231
124glycerolipid catabolic process (GO:0046503)3.38176698
125high-density lipoprotein particle remodeling (GO:0034375)3.37030179
126* acylglycerol metabolic process (GO:0006639)3.35263269
127tryptophan metabolic process (GO:0006568)3.35210376
128negative regulation of fatty acid biosynthetic process (GO:0045717)3.35035214
129cGMP-mediated signaling (GO:0019934)3.33801153
130fructose metabolic process (GO:0006000)3.30768900
131* neutral lipid metabolic process (GO:0006638)3.30693995
132long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.30228757
133coenzyme catabolic process (GO:0009109)3.29046742
134coenzyme A metabolic process (GO:0015936)3.28560856
135fatty acid homeostasis (GO:0055089)3.27650751
136alditol metabolic process (GO:0019400)3.27413169
137coenzyme A biosynthetic process (GO:0015937)3.26060542
138retinol metabolic process (GO:0042572)3.25710640
139phospholipid homeostasis (GO:0055091)3.24477014
140ovulation from ovarian follicle (GO:0001542)3.18741953
141* NADH metabolic process (GO:0006734)3.16149866
142cellular polysaccharide catabolic process (GO:0044247)3.15630525
143regulation of lipid storage (GO:0010883)3.13324922
144negative regulation of macrophage differentiation (GO:0045650)3.11809689
145muscle filament sliding (GO:0030049)3.11780169
146actin-myosin filament sliding (GO:0033275)3.11780169
147positive regulation of glucose import (GO:0046326)3.09651774
148lipoprotein transport (GO:0042953)3.08283592
149negative regulation of protein autophosphorylation (GO:0031953)3.01356459
150retina vasculature morphogenesis in camera-type eye (GO:0061299)3.00643375
151positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.99690935
152regulation of cholesterol transport (GO:0032374)2.98579648
153regulation of sterol transport (GO:0032371)2.98579648
154negative regulation of smooth muscle cell migration (GO:0014912)2.92758515

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.30066287
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.17066718
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.36114618
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.00303906
5* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.65123350
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.93832289
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.82668517
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.41137739
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.95550123
10CLOCK_20551151_ChIP-Seq_293T_Human2.87583134
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.12148379
12* PPARG_19300518_ChIP-PET_3T3-L1_Mouse10.0014759
13ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.83825883
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.74345463
15RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54720889
16* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.53098189
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.51854916
18ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.45022393
19ZNF263_19887448_ChIP-Seq_K562_Human1.38279567
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34952840
21GATA1_22025678_ChIP-Seq_K562_Human1.29610798
22BP1_19119308_ChIP-ChIP_Hs578T_Human1.29609084
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28430652
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27764410
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22664264
26* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.22567382
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.20510543
28BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20461917
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.18862677
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16382348
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15781039
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15269270
33* HNF4A_19822575_ChIP-Seq_HepG2_Human1.14042464
34PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.10462540
35* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.10138360
36CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07145643
37SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06111114
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05741548
39RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05693616
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05328507
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05328507
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.03374310
43NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03245385
44* CTCF_27219007_Chip-Seq_Bcells_Human1.02096955
45EZH2_22144423_ChIP-Seq_EOC_Human0.98322895
46NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96198149
47TBX20_22328084_ChIP-Seq_HEART_Mouse0.94657332
48TBX20_22080862_ChIP-Seq_HEART_Mouse0.94657332
49TRIM28_21343339_ChIP-Seq_HEK293_Human0.93933655
50* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.91249472
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90819408
52CJUN_26792858_Chip-Seq_BT549_Human0.89893154
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.89250976
54SA1_22415368_ChIP-Seq_MEFs_Mouse0.89234701
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88517529
56NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88517529
57FOXO3_23340844_ChIP-Seq_DLD1_Human0.87687770
58KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86960372
59* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86020693
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.85364105
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.85031972
62AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84962740
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84172362
64* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.83865897
65SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.83722952
66ELK3_25401928_ChIP-Seq_HUVEC_Human0.83505149
67SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83303954
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81614669
69GATA4_25053715_ChIP-Seq_YYC3_Human0.81016562
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.80885335
71CDX2_19796622_ChIP-Seq_MESCs_Mouse0.79279684
72NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.77041605
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76126083
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.75890225
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.75833895
76MYC_27129775_Chip-Seq_CORNEA_Mouse0.74703769
77* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.73938742
78CDX2_20551321_ChIP-Seq_CACO-2_Human0.73778021
79LXR_22292898_ChIP-Seq_THP-1_Human0.73633872
80GATA1_19941826_ChIP-Seq_K562_Human0.73071032
81* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.72266629
82* SA1_27219007_Chip-Seq_Bcells_Human0.71755860
83EP300_21415370_ChIP-Seq_HL-1_Mouse0.70698850
84KDM2B_26808549_Chip-Seq_K562_Human0.70397742
85AUTS2_25519132_ChIP-Seq_293T-REX_Human0.69115703
86CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.68913388
87EED_16625203_ChIP-ChIP_MESCs_Mouse0.68709520
88* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.68669698
89LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.68171600
90BCAT_22108803_ChIP-Seq_LS180_Human0.68036546
91HTT_18923047_ChIP-ChIP_STHdh_Human0.67795646
92RXR_22108803_ChIP-Seq_LS180_Human0.67514493
93STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.67233711
94JARID2_20075857_ChIP-Seq_MESCs_Mouse0.66470323
95TP53_20018659_ChIP-ChIP_R1E_Mouse0.66251864
96STAT1_20625510_ChIP-Seq_HELA_Human0.65903528
97TET1_21490601_ChIP-Seq_MESCs_Mouse0.65876397
98GATA2_19941826_ChIP-Seq_K562_Human0.65621644
99CEBPB_22108803_ChIP-Seq_LS180_Human0.65397354
100RXRA_24833708_ChIP-Seq_LIVER_Mouse0.64835344
101ESR1_21235772_ChIP-Seq_MCF-7_Human0.64582970
102RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63384655
103ERG_21242973_ChIP-ChIP_JURKAT_Human0.62768070
104ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.62699019
105EGR1_19032775_ChIP-ChIP_M12_Human0.61589569
106RACK7_27058665_Chip-Seq_MCF-7_Human0.60752317
107FOXA1_25552417_ChIP-Seq_VCAP_Human0.58721934
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.58129681
109FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.56915036
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.56762715
111SALL4_18804426_ChIP-ChIP_XEN_Mouse0.56598456
112PIAS1_25552417_ChIP-Seq_VCAP_Human0.56132610
113GATA2_21666600_ChIP-Seq_HMVEC_Human0.56130012
114GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.55502881
115ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.55398438
116SOX2_20726797_ChIP-Seq_SW620_Human0.54887263
117CBP_21632823_ChIP-Seq_H3396_Human0.54399959
118IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.53823822
119SOX9_24532713_ChIP-Seq_HFSC_Mouse0.52977632
120* KLF4_19829295_ChIP-Seq_ESCs_Human0.51818257
121GATA3_24758297_ChIP-Seq_MCF-7_Human0.51544216
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.50745922
123KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.50097756
124ERG_20517297_ChIP-Seq_VCAP_Human0.49626946
125P63_26484246_Chip-Seq_KERATINOCYTES_Human0.49087226
126P300_27058665_Chip-Seq_ZR-75-30cells_Human0.48844259
127CBP_20019798_ChIP-Seq_JUKART_Human0.48844016
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.48844016
129* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.48617480
130MTF2_20144788_ChIP-Seq_MESCs_Mouse0.48274099
131DNAJC2_21179169_ChIP-ChIP_NT2_Human0.47796389
132NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.47248177
133SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47136981
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.46654856

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.97856899
2MP0005360_urolithiasis5.67812002
3MP0005670_abnormal_white_adipose4.84476609
4MP0005365_abnormal_bile_salt4.57127358
5MP0005085_abnormal_gallbladder_physiolo4.12701469
6MP0010329_abnormal_lipoprotein_level3.70902803
7MP0004130_abnormal_muscle_cell3.52086788
8MP0005666_abnormal_adipose_tissue3.49999303
9MP0008875_abnormal_xenobiotic_pharmacok3.08745121
10MP0004185_abnormal_adipocyte_glucose2.83305499
11MP0005332_abnormal_amino_acid2.73373992
12MP0002971_abnormal_brown_adipose2.71346173
13MP0003252_abnormal_bile_duct2.65442733
14MP0002118_abnormal_lipid_homeostasis2.62166893
15MP0003806_abnormal_nucleotide_metabolis2.52131169
16MP0003191_abnormal_cellular_cholesterol2.47815733
17MP0005375_adipose_tissue_phenotype2.38179596
18MP0009840_abnormal_foam_cell2.25514539
19MP0002837_dystrophic_cardiac_calcinosis2.25480137
20MP0000609_abnormal_liver_physiology2.07824292
21MP0004145_abnormal_muscle_electrophysio2.07078355
22MP0001666_abnormal_nutrient_absorption2.00330815
23MP0003195_calcinosis1.97870095
24MP0005535_abnormal_body_temperature1.92152984
25MP0003828_pulmonary_edema1.81545234
26MP0005334_abnormal_fat_pad1.77046698
27MP0006036_abnormal_mitochondrial_physio1.75101932
28* MP0005584_abnormal_enzyme/coenzyme_acti1.73864324
29MP0004019_abnormal_vitamin_homeostasis1.73404434
30MP0005319_abnormal_enzyme/_coenzyme1.64400247
31MP0005083_abnormal_biliary_tract1.58275493
32MP0009115_abnormal_fat_cell1.57702809
33MP0000003_abnormal_adipose_tissue1.57023890
34MP0000013_abnormal_adipose_tissue1.56954086
35MP0003646_muscle_fatigue1.56076415
36MP0002108_abnormal_muscle_morphology1.50052207
37MP0002876_abnormal_thyroid_physiology1.47271352
38MP0008438_abnormal_cutaneous_collagen1.47086933
39MP0003705_abnormal_hypodermis_morpholog1.44057822
40MP0009643_abnormal_urine_homeostasis1.43392493
41MP0002078_abnormal_glucose_homeostasis1.42309935
42MP0002970_abnormal_white_adipose1.38849787
43MP0003186_abnormal_redox_activity1.38523285
44MP0001661_extended_life_span1.38052717
45MP0005448_abnormal_energy_balance1.34169765
46MP0002106_abnormal_muscle_physiology1.31605981
47MP0001764_abnormal_homeostasis1.31595473
48MP0003690_abnormal_glial_cell1.31225464
49MP0005369_muscle_phenotype1.28968626
50MP0002638_abnormal_pupillary_reflex1.25092787
51MP0004043_abnormal_pH_regulation1.24306650
52MP0004215_abnormal_myocardial_fiber1.22332928
53MP0003950_abnormal_plasma_membrane1.21531222
54MP0004084_abnormal_cardiac_muscle1.19242859
55MP0000343_altered_response_to1.14196586
56MP0002972_abnormal_cardiac_muscle1.13915151
57MP0005503_abnormal_tendon_morphology1.11817986
58MP0003959_abnormal_lean_body1.04832499
59MP0000604_amyloidosis1.03098927
60MP0000750_abnormal_muscle_regeneration1.02518065
61MP0003329_amyloid_beta_deposits0.98354535
62MP0001756_abnormal_urination0.96643478
63MP0003011_delayed_dark_adaptation0.96276495
64MP0005451_abnormal_body_composition0.95375580
65MP0005452_abnormal_adipose_tissue0.94857594
66MP0002254_reproductive_system_inflammat0.91215821
67MP0002138_abnormal_hepatobiliary_system0.90095504
68MP0003948_abnormal_gas_homeostasis0.88483151
69MP0005275_abnormal_skin_tensile0.87508551
70MP0005330_cardiomyopathy0.87426547
71MP0003879_abnormal_hair_cell0.86204706
72MP0000598_abnormal_liver_morphology0.85872879
73MP0008961_abnormal_basal_metabolism0.85152674
74MP0003724_increased_susceptibility_to0.83693914
75MP0000249_abnormal_blood_vessel0.83245958
76MP0005595_abnormal_vascular_smooth0.83182957
77MP0001881_abnormal_mammary_gland0.80902577
78MP0005636_abnormal_mineral_homeostasis0.80194155
79MP0003868_abnormal_feces_composition0.78273354
80MP0010630_abnormal_cardiac_muscle0.77979971
81MP0009642_abnormal_blood_homeostasis0.77413419
82MP0003953_abnormal_hormone_level0.77359958
83MP0003656_abnormal_erythrocyte_physiolo0.76946515
84MP0004087_abnormal_muscle_fiber0.76576690
85MP0005379_endocrine/exocrine_gland_phen0.76561779
86MP0002332_abnormal_exercise_endurance0.75872973
87MP0000733_abnormal_muscle_development0.74223231
88MP0000230_abnormal_systemic_arterial0.73431015
89MP0006138_congestive_heart_failure0.73355182
90MP0000751_myopathy0.73312259
91MP0004147_increased_porphyrin_level0.73285932
92MP0002796_impaired_skin_barrier0.73123830
93MP0009763_increased_sensitivity_to0.73072223
94MP0005266_abnormal_metabolism0.72918968
95MP0006035_abnormal_mitochondrial_morpho0.71282810
96MP0005647_abnormal_sex_gland0.71076697
97MP0004484_altered_response_of0.70991448
98MP0005620_abnormal_muscle_contractility0.70579026
99MP0005376_homeostasis/metabolism_phenot0.70489188
100MP0003221_abnormal_cardiomyocyte_apopto0.70401436
101MP0001501_abnormal_sleep_pattern0.70150002
102MP0009780_abnormal_chondrocyte_physiolo0.69493486
103MP0000747_muscle_weakness0.67788331
104MP0003279_aneurysm0.67435482
105MP0002909_abnormal_adrenal_gland0.67189071
106MP0002269_muscular_atrophy0.67000250
107MP0000749_muscle_degeneration0.65338665
108MP0005164_abnormal_response_to0.61859556
109MP0001879_abnormal_lymphatic_vessel0.59367975
110MP0002933_joint_inflammation0.59212353
111MP0008775_abnormal_heart_ventricle0.59140265
112MP0001544_abnormal_cardiovascular_syste0.59052408
113MP0005385_cardiovascular_system_phenoty0.59052408
114MP0001727_abnormal_embryo_implantation0.58729212
115MP0008872_abnormal_physiological_respon0.58538048
116MP0005058_abnormal_lysosome_morphology0.58268260
117MP0000759_abnormal_skeletal_muscle0.57221261
118MP0004782_abnormal_surfactant_physiolog0.54690734
119MP0002136_abnormal_kidney_physiology0.54687333
120MP0010368_abnormal_lymphatic_system0.54423379
121MP0004036_abnormal_muscle_relaxation0.53683679
122MP0009764_decreased_sensitivity_to0.52807510
123MP0002822_catalepsy0.52481007
124MP0002168_other_aberrant_phenotype0.52063716
125MP0002295_abnormal_pulmonary_circulatio0.51821340
126MP0003075_altered_response_to0.51395828
127MP0008469_abnormal_protein_level0.51326408
128MP0001765_abnormal_ion_homeostasis0.51310586
129MP0009672_abnormal_birth_weight0.51272509
130MP0005084_abnormal_gallbladder_morpholo0.50370848
131MP0004272_abnormal_basement_membrane0.50334553
132MP0005167_abnormal_blood-brain_barrier0.49779763

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)6.03255536
2Muscle fiber inclusion bodies (HP:0100299)5.71820275
3Nemaline bodies (HP:0003798)5.60377494
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.40201506
5Abnormality of glycine metabolism (HP:0010895)5.38931635
6Abnormality of serine family amino acid metabolism (HP:0010894)5.38931635
7Type 1 muscle fiber predominance (HP:0003803)5.09318229
8Increased variability in muscle fiber diameter (HP:0003557)4.95893685
9Hypoglycemic coma (HP:0001325)4.91329377
10Abnormality of skeletal muscle fiber size (HP:0012084)4.85939641
11Abnormality of fatty-acid metabolism (HP:0004359)4.85349575
12Xanthomatosis (HP:0000991)4.78780231
13Hyperammonemia (HP:0001987)4.73777634
14Ketosis (HP:0001946)4.67531290
15Hyperglycinemia (HP:0002154)4.45681412
16Abnormality of aromatic amino acid family metabolism (HP:0004338)4.30775916
17Myoglobinuria (HP:0002913)4.29579499
18Muscle fiber splitting (HP:0003555)4.22979576
19Ketoacidosis (HP:0001993)4.22103913
20Hyperlipoproteinemia (HP:0010980)4.17092031
21Intrahepatic cholestasis (HP:0001406)4.15423189
22Dicarboxylic aciduria (HP:0003215)4.08474480
23Abnormality of dicarboxylic acid metabolism (HP:0010995)4.08474480
24Deep venous thrombosis (HP:0002625)4.06348174
25Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.05016370
26Abnormality of glutamine family amino acid metabolism (HP:0010902)4.02356555
27Complement deficiency (HP:0004431)3.91144429
28Neck muscle weakness (HP:0000467)3.86148756
29Hypoalphalipoproteinemia (HP:0003233)3.85908277
30Epidermoid cyst (HP:0200040)3.81938545
31Rhabdomyolysis (HP:0003201)3.56255805
32Hypolipoproteinemia (HP:0010981)3.56249821
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.54168217
34Oligomenorrhea (HP:0000876)3.53617336
35Hypobetalipoproteinemia (HP:0003563)3.51982102
36Hydroxyprolinuria (HP:0003080)3.48759017
37Abnormality of proline metabolism (HP:0010907)3.48759017
38Exercise-induced muscle cramps (HP:0003710)3.47775180
39Abnormality of monocarboxylic acid metabolism (HP:0010996)3.43664417
40Hyporeflexia of lower limbs (HP:0002600)3.39684868
41Frequent falls (HP:0002359)3.29683829
42Generalized aminoaciduria (HP:0002909)3.29538386
43Myopathic facies (HP:0002058)3.19680542
44EMG: myopathic abnormalities (HP:0003458)3.19453339
45Hypertriglyceridemia (HP:0002155)3.17799730
46Muscle hypertrophy of the lower extremities (HP:0008968)3.13618716
47Prolonged partial thromboplastin time (HP:0003645)3.11201714
48Spinal rigidity (HP:0003306)3.09927120
49Asymmetric septal hypertrophy (HP:0001670)3.06542898
50Rimmed vacuoles (HP:0003805)3.05847684
51Distal arthrogryposis (HP:0005684)3.04851125
52Increased muscle lipid content (HP:0009058)3.01662373
53Metabolic acidosis (HP:0001942)2.98304591
54Abnormality of serum amino acid levels (HP:0003112)2.96477710
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.93733771
56Abnormality of purine metabolism (HP:0004352)2.93042763
57Lethargy (HP:0001254)2.93007441
58Round ear (HP:0100830)2.92415940
59Protrusio acetabuli (HP:0003179)2.91551250
60Acanthosis nigricans (HP:0000956)2.91516575
61Myotonia (HP:0002486)2.76991587
62Proximal tubulopathy (HP:0000114)2.75171112
63Hypercholesterolemia (HP:0003124)2.75142985
64Nausea (HP:0002018)2.74818396
65Cerebral edema (HP:0002181)2.73533875
66Hepatic necrosis (HP:0002605)2.69416027
67Exercise-induced myalgia (HP:0003738)2.67659280
68Calf muscle hypertrophy (HP:0008981)2.67077653
69Centrally nucleated skeletal muscle fibers (HP:0003687)2.67071336
70Abnormality of complement system (HP:0005339)2.66618129
71Gowers sign (HP:0003391)2.60684402
72Abnormality of sulfur amino acid metabolism (HP:0004339)2.57122991
73Vomiting (HP:0002013)2.56956217
74Lipoatrophy (HP:0100578)2.54973256
75Skin nodule (HP:0200036)2.53206138
76Back pain (HP:0003418)2.51913749
77Gout (HP:0001997)2.49644799
78Increased purine levels (HP:0004368)2.47217521
79Hyperuricemia (HP:0002149)2.47217521
80Ulnar deviation of the wrist (HP:0003049)2.45898084
81Abnormality of the common coagulation pathway (HP:0010990)2.45429202
82Pancreatitis (HP:0001733)2.45293723
83Abnormality of the calf musculature (HP:0001430)2.45283398
84Myocardial infarction (HP:0001658)2.42437495
85Abnormality of nucleobase metabolism (HP:0010932)2.38902338
86Difficulty running (HP:0009046)2.38635841
87Bulbar palsy (HP:0001283)2.37714342
88Delayed CNS myelination (HP:0002188)2.37290100
89Methylmalonic aciduria (HP:0012120)2.32294510
90Axonal loss (HP:0003447)2.32291503
91Mildly elevated creatine phosphokinase (HP:0008180)2.32275052
92Renal cortical cysts (HP:0000803)2.32142534
93Fat malabsorption (HP:0002630)2.30916241
94Hypoglycemic seizures (HP:0002173)2.30673743
95Distal lower limb muscle weakness (HP:0009053)2.30288031
96Growth hormone excess (HP:0000845)2.26759673
97Abnormality of glycolysis (HP:0004366)2.25321069
98Increased serum pyruvate (HP:0003542)2.25321069
99Joint hemorrhage (HP:0005261)2.23546314
100Reduced subcutaneous adipose tissue (HP:0003758)2.22689378
101Insulin-resistant diabetes mellitus (HP:0000831)2.21364408
102Muscle stiffness (HP:0003552)2.21060177
103Scapular winging (HP:0003691)2.17927606
104Ileus (HP:0002595)2.17384441
105Hypercortisolism (HP:0001578)2.16054621
106Abnormality of methionine metabolism (HP:0010901)2.15778093
107Abnormal eating behavior (HP:0100738)2.14262071
108Polycythemia (HP:0001901)2.11786345
109Abnormality of the left ventricular outflow tract (HP:0011103)2.11117338
110Subaortic stenosis (HP:0001682)2.11117338
111Dilated cardiomyopathy (HP:0001644)2.09505729
112Hyperbilirubinemia (HP:0002904)2.09144504
113Hyperglycemia (HP:0003074)2.07603542
114Hemorrhage of the eye (HP:0011885)2.06886904
115Cholelithiasis (HP:0001081)2.05818814
116Vertebral compression fractures (HP:0002953)2.05584372
117Hyperinsulinemic hypoglycemia (HP:0000825)2.05484307
118Brushfield spots (HP:0001088)2.05430530
119Abnormal gallbladder morphology (HP:0012437)2.03991426
120Insulin resistance (HP:0000855)2.03944031
121Subcapsular cataract (HP:0000523)2.03749771
122Abnormality of urine glucose concentration (HP:0011016)2.03440131
123Glycosuria (HP:0003076)2.03440131
124Sensorimotor neuropathy (HP:0007141)2.02678054
125Abnormal gallbladder physiology (HP:0012438)2.02550695
126Cholecystitis (HP:0001082)2.02550695
127Acute encephalopathy (HP:0006846)2.02470891
128Abnormality of the intrinsic pathway (HP:0010989)2.02432310
129Slender build (HP:0001533)2.02188009
130Foot dorsiflexor weakness (HP:0009027)1.98062487
131Polar cataract (HP:0010696)1.96644265
132Abnormal cartilage morphology (HP:0002763)1.95983606
133Generalized muscle weakness (HP:0003324)1.95895813
134Infantile muscular hypotonia (HP:0008947)1.95060612
135Neonatal onset (HP:0003623)1.93332939
136Sudden death (HP:0001699)1.91868108
137Atrioventricular block (HP:0001678)1.91576726
138Distal lower limb amyotrophy (HP:0008944)1.91424517
139Irritability (HP:0000737)1.91233384
140Stridor (HP:0010307)1.91153928
141Easy fatigability (HP:0003388)1.90935217
142Abnormality of the foot musculature (HP:0001436)1.90523886
143Pigmentary retinal degeneration (HP:0001146)1.89076922
144Abnormality of alanine metabolism (HP:0010916)1.86043235
145Hyperalaninemia (HP:0003348)1.86043235
146Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86043235
147Methylmalonic acidemia (HP:0002912)1.83810779
148Abnormal atrioventricular conduction (HP:0005150)1.83027276
149EMG: neuropathic changes (HP:0003445)1.82951892
150Limb hypertonia (HP:0002509)1.82057681
151Conjugated hyperbilirubinemia (HP:0002908)1.81327029
152Late onset (HP:0003584)1.81201745
153Lactic acidosis (HP:0003128)1.80820684
154Cerebral hemorrhage (HP:0001342)1.80582154
155Heart block (HP:0012722)1.79767498
156Hepatocellular carcinoma (HP:0001402)1.77453500
157Increased connective tissue (HP:0009025)1.77023323
158Systemic lupus erythematosus (HP:0002725)1.76089530
159Turricephaly (HP:0000262)1.75454261
160Tachypnea (HP:0002789)1.72686711
161Bone cyst (HP:0012062)1.72075613

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.39842950
2TRIB34.18823338
3CAMK1D4.10881904
4SIK14.02733421
5PDK43.47597101
6PDK33.47597101
7CAMK1G3.08385806
8ERN12.72096151
9DDR22.29364028
10PDK22.27030024
11INSRR2.16771505
12FGFR41.92303585
13MST1R1.82394284
14PRKAA21.82056348
15TESK11.79012281
16RIPK11.74656599
17MYLK1.67851041
18PKN21.56531241
19MAPKAPK31.55481921
20EEF2K1.51233432
21PINK11.49355152
22LMTK21.48617395
23FGFR21.40580920
24FRK1.37936918
25MAP2K41.33731520
26PHKG21.32788091
27PHKG11.32788091
28EPHA31.28453406
29TRPM71.24405601
30PDPK11.19408242
31MAP3K131.15928732
32LATS11.15387079
33MAPK111.12783052
34WNK41.12730292
35PRKAA11.12031947
36MOS1.09707207
37OBSCN1.01975693
38MAP3K71.00088097
39EPHB10.98977202
40ARAF0.97105419
41PRPF4B0.96322265
42DAPK20.95627933
43OXSR10.94419443
44PDK10.92778835
45TTN0.92591640
46MET0.91920235
47MAP2K10.91856925
48ERBB40.88620166
49GRK50.88219769
50TIE10.87823420
51PIK3CA0.87511341
52MAPK70.87163886
53NLK0.87057505
54PTK60.84909373
55PRKG10.83658946
56PDGFRA0.83184452
57STK390.80770959
58PIK3CG0.78600374
59PRKACG0.76850187
60JAK10.75293549
61JAK20.75226734
62NEK90.75047194
63CDK90.73583834
64KSR20.72556589
65SGK4940.72468609
66SGK2230.72468609
67GSK3A0.71463769
68FLT30.69241211
69MARK10.69107932
70MAPK120.68921066
71FGFR30.68143960
72ABL20.67934278
73PRKCH0.67786646
74MAP2K30.67080656
75CDK60.65747519
76CAMKK20.63380737
77PRKD30.63084972
78CSK0.62007321
79SGK30.61806048
80RET0.61646311
81MAP3K10.61342966
82TBK10.60420321
83AKT20.59848072
84CDC42BPA0.58389464
85TGFBR20.56602030
86RIPK40.54446649
87DYRK1B0.54126540
88ICK0.53930324
89MAP3K60.53490831
90BMX0.52367873
91STK38L0.51130321
92PRKD10.50789957
93PRKCZ0.50124804
94STK380.49481903
95CAMK2G0.49078708
96PKN10.47016689
97NEK10.46659878
98MAPK30.46518728
99PRKACB0.46337242
100MTOR0.45675701
101MAP3K20.45100264
102DMPK0.44302859
103ADRBK10.43610149
104MAP2K60.43079304
105FER0.42186879
106ILK0.41555783
107WNK30.41534116
108TAOK30.41313326
109PAK60.40469319
110MAPK40.39825406
111PRKG20.39070542
112MUSK0.38491570
113LATS20.38236922
114IGF1R0.37963205
115CDK40.37098704
116ZAP700.36436258
117KIT0.35938629
118CAMK40.35656313
119PTK2B0.35394709
120CAMK10.34053300
121DAPK30.33239981
122TYK20.32959740
123MAP3K30.32559804
124STK110.32422374
125MAP3K110.32337699
126FGFR10.31378906
127NTRK10.31211810
128EPHB20.29730433
129PAK30.27954613
130EPHA40.27524849
131RPS6KA30.27052185
132SGK20.26535036
133IRAK30.25520997
134PRKACA0.25488451
135PDGFRB0.25213555
136PTK20.24181070
137WNK10.24114293

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.77595686
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.44146355
3Fatty acid degradation_Homo sapiens_hsa000713.42877862
4Fatty acid metabolism_Homo sapiens_hsa012123.14465254
5Nitrogen metabolism_Homo sapiens_hsa009103.11387953
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.03850173
7PPAR signaling pathway_Homo sapiens_hsa033202.96645332
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.91484048
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.85005136
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.76271485
11Butanoate metabolism_Homo sapiens_hsa006502.44315563
12Fatty acid biosynthesis_Homo sapiens_hsa000612.36592099
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.35790414
14Pyruvate metabolism_Homo sapiens_hsa006202.23908019
15Tryptophan metabolism_Homo sapiens_hsa003802.20431845
16Arginine biosynthesis_Homo sapiens_hsa002202.10949193
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.09890110
18Peroxisome_Homo sapiens_hsa041462.03466293
19Fatty acid elongation_Homo sapiens_hsa000621.95646052
20beta-Alanine metabolism_Homo sapiens_hsa004101.95451923
21Carbon metabolism_Homo sapiens_hsa012001.92604315
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.92324540
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.81512217
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64764417
25Fat digestion and absorption_Homo sapiens_hsa049751.52895275
26Glycerolipid metabolism_Homo sapiens_hsa005611.52315676
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.46779383
28Complement and coagulation cascades_Homo sapiens_hsa046101.46311032
29Caffeine metabolism_Homo sapiens_hsa002321.44374547
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.37642421
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36259357
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31653973
33Starch and sucrose metabolism_Homo sapiens_hsa005001.22002266
34Sulfur metabolism_Homo sapiens_hsa009201.20371653
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20080914
36Biosynthesis of amino acids_Homo sapiens_hsa012301.19073391
37Histidine metabolism_Homo sapiens_hsa003401.17533365
38Phenylalanine metabolism_Homo sapiens_hsa003601.17387019
39Bile secretion_Homo sapiens_hsa049761.17360697
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09602602
41Tyrosine metabolism_Homo sapiens_hsa003501.07789921
42Chemical carcinogenesis_Homo sapiens_hsa052041.07542483
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05933413
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03160763
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.97959045
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97337799
47Adipocytokine signaling pathway_Homo sapiens_hsa049200.96362652
48Retinol metabolism_Homo sapiens_hsa008300.94586088
49Staphylococcus aureus infection_Homo sapiens_hsa051500.91662203
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.91149707
51Vitamin B6 metabolism_Homo sapiens_hsa007500.90823223
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89613447
53ABC transporters_Homo sapiens_hsa020100.87868046
54Dilated cardiomyopathy_Homo sapiens_hsa054140.87499527
55Lysine degradation_Homo sapiens_hsa003100.84370651
56Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79705549
57AMPK signaling pathway_Homo sapiens_hsa041520.77102289
58Pentose phosphate pathway_Homo sapiens_hsa000300.76964170
59Selenocompound metabolism_Homo sapiens_hsa004500.73976616
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.72844601
61Vitamin digestion and absorption_Homo sapiens_hsa049770.69903102
62Folate biosynthesis_Homo sapiens_hsa007900.69856861
63Insulin resistance_Homo sapiens_hsa049310.68361154
64Arginine and proline metabolism_Homo sapiens_hsa003300.63917453
65Glucagon signaling pathway_Homo sapiens_hsa049220.59377841
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.59285379
67ECM-receptor interaction_Homo sapiens_hsa045120.55129572
68Sulfur relay system_Homo sapiens_hsa041220.54424626
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.53261788
70Circadian rhythm_Homo sapiens_hsa047100.52373183
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52109569
72Steroid biosynthesis_Homo sapiens_hsa001000.52068905
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50890833
74Glutathione metabolism_Homo sapiens_hsa004800.50459428
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50324590
76Fructose and mannose metabolism_Homo sapiens_hsa000510.49243846
77Insulin signaling pathway_Homo sapiens_hsa049100.46094798
78Metabolic pathways_Homo sapiens_hsa011000.44276180
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44019026
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43914579
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40541260
82* Glycerophospholipid metabolism_Homo sapiens_hsa005640.39396492
83Galactose metabolism_Homo sapiens_hsa000520.38854012
84Focal adhesion_Homo sapiens_hsa045100.36644282
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.36589094
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30528862
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23278712
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23040238
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18292302
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.16183340
91Oxytocin signaling pathway_Homo sapiens_hsa049210.14972605
92Malaria_Homo sapiens_hsa051440.14849912
93Oxidative phosphorylation_Homo sapiens_hsa001900.14450821
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.12998534
95Protein digestion and absorption_Homo sapiens_hsa049740.11605736
96Type II diabetes mellitus_Homo sapiens_hsa049300.11509514
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.10677150
98GnRH signaling pathway_Homo sapiens_hsa049120.10545735
99cAMP signaling pathway_Homo sapiens_hsa040240.09932214
100Alzheimers disease_Homo sapiens_hsa050100.09116629
101Prion diseases_Homo sapiens_hsa050200.09114200
102Parkinsons disease_Homo sapiens_hsa050120.09005169
103FoxO signaling pathway_Homo sapiens_hsa040680.08720993
104Linoleic acid metabolism_Homo sapiens_hsa005910.08381921
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.07586384
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.06961687
107Renin-angiotensin system_Homo sapiens_hsa046140.04564207
108Renin secretion_Homo sapiens_hsa049240.02493441
109Thyroid hormone synthesis_Homo sapiens_hsa049180.01522527
110Ovarian steroidogenesis_Homo sapiens_hsa049130.00135091
111Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1171877
112Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0991571
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0915400
114Cardiac muscle contraction_Homo sapiens_hsa04260-0.0885091
115Mineral absorption_Homo sapiens_hsa04978-0.0286288
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0263605

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »