GPD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.52457456
2sperm motility (GO:0030317)6.35832410
3cell wall macromolecule catabolic process (GO:0016998)5.71240306
4cell wall macromolecule metabolic process (GO:0044036)5.71240306
5nuclear pore organization (GO:0006999)5.45703743
6fusion of sperm to egg plasma membrane (GO:0007342)5.18669958
7NADH metabolic process (GO:0006734)5.16910533
8carnitine shuttle (GO:0006853)5.04451582
9pore complex assembly (GO:0046931)4.91993124
10acrosome assembly (GO:0001675)4.78599730
11carnitine transmembrane transport (GO:1902603)4.77855417
12negative regulation of inclusion body assembly (GO:0090084)4.71270139
13acrosome reaction (GO:0007340)4.71174678
14mitotic sister chromatid cohesion (GO:0007064)4.68389784
15carnitine transport (GO:0015879)4.65843180
16amino-acid betaine transport (GO:0015838)4.65843180
17biotin metabolic process (GO:0006768)4.64244189
18spermatid development (GO:0007286)4.58514078
19CDP-diacylglycerol metabolic process (GO:0046341)4.54894310
20sperm-egg recognition (GO:0035036)4.52841277
21fatty acid transmembrane transport (GO:1902001)4.45059720
22regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.36961077
23CDP-diacylglycerol biosynthetic process (GO:0016024)4.34288460
24mitotic chromosome condensation (GO:0007076)4.32483385
25plasma membrane fusion (GO:0045026)4.31313121
26multicellular organism reproduction (GO:0032504)4.30134284
27triglyceride biosynthetic process (GO:0019432)4.04909069
28cell-cell recognition (GO:0009988)4.03351389
29tricarboxylic acid cycle (GO:0006099)4.02968582
30regulation of centriole replication (GO:0046599)4.01249542
31fructose metabolic process (GO:0006000)4.00637081
32reproduction (GO:0000003)3.99791950
33binding of sperm to zona pellucida (GO:0007339)3.98826678
34sperm capacitation (GO:0048240)3.94234887
35protein localization to endosome (GO:0036010)3.91463946
36DNA unwinding involved in DNA replication (GO:0006268)3.90016419
37acylglycerol biosynthetic process (GO:0046463)3.86421430
38neutral lipid biosynthetic process (GO:0046460)3.86421430
39epithelial cilium movement (GO:0003351)3.83800878
40regulation of acyl-CoA biosynthetic process (GO:0050812)3.79073722
41regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.78587668
42calcium ion-dependent exocytosis (GO:0017156)3.70311920
43regulation of inclusion body assembly (GO:0090083)3.66719763
44regulation of cilium movement (GO:0003352)3.66329967
45nucleobase-containing small molecule interconversion (GO:0015949)3.65715553
46regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.62598467
47regulation of sequestering of triglyceride (GO:0010889)3.61070147
48axonemal dynein complex assembly (GO:0070286)3.59430117
49cilium or flagellum-dependent cell motility (GO:0001539)3.58398453
50regulation of coenzyme metabolic process (GO:0051196)3.56986931
51regulation of cofactor metabolic process (GO:0051193)3.56986931
52mitotic sister chromatid segregation (GO:0000070)3.56071826
53synaptonemal complex assembly (GO:0007130)3.53333901
54synaptonemal complex organization (GO:0070193)3.46185813
55hemidesmosome assembly (GO:0031581)3.44835707
56negative regulation of protein localization to plasma membrane (GO:1903077)3.40201922
57cellular protein complex localization (GO:0034629)3.39135119
58peptidyl-threonine dephosphorylation (GO:0035970)3.38013168
59sister chromatid segregation (GO:0000819)3.35423915
60pantothenate metabolic process (GO:0015939)3.32692731
61desmosome organization (GO:0002934)3.31076986
62cytoskeletal anchoring at plasma membrane (GO:0007016)3.30409733
63quaternary ammonium group transport (GO:0015697)3.29763796
64regulation of transforming growth factor beta2 production (GO:0032909)3.28105537
65thioester biosynthetic process (GO:0035384)3.26631762
66acyl-CoA biosynthetic process (GO:0071616)3.26631762
67organic cation transport (GO:0015695)3.25631489
68intestinal absorption (GO:0050892)3.25125944
69Golgi transport vesicle coating (GO:0048200)3.23424380
70COPI coating of Golgi vesicle (GO:0048205)3.23424380
71positive regulation of glycolytic process (GO:0045821)3.23065673
72bundle of His cell to Purkinje myocyte communication (GO:0086069)3.20064091
73alanine transport (GO:0032328)3.16983674
74epithelial cell-cell adhesion (GO:0090136)3.13436133
75protein complex localization (GO:0031503)3.10949298
76positive regulation of Cdc42 GTPase activity (GO:0043089)3.09793752
77glycine transport (GO:0015816)3.09540500
78proline transport (GO:0015824)3.09314241
79metaphase plate congression (GO:0051310)3.08892881
80protein localization to chromosome, centromeric region (GO:0071459)3.08608401
81fatty-acyl-CoA biosynthetic process (GO:0046949)3.07897659
82vitamin transmembrane transport (GO:0035461)3.06953377
83establishment of chromosome localization (GO:0051303)3.06622189
84fatty acid beta-oxidation (GO:0006635)3.04892517
85cell adhesion mediated by integrin (GO:0033627)3.03933978
86chaperone-mediated protein complex assembly (GO:0051131)3.00989652
87mitotic metaphase plate congression (GO:0007080)2.98794405
88purine nucleobase biosynthetic process (GO:0009113)2.96231838
89* alditol metabolic process (GO:0019400)2.96168255
90low-density lipoprotein particle clearance (GO:0034383)2.94610604
91sexual reproduction (GO:0019953)2.93593784
92intracellular lipid transport (GO:0032365)2.92802693
93regulation of sulfur metabolic process (GO:0042762)2.91930930
94long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.91086965
95mammary gland epithelial cell proliferation (GO:0033598)2.90983909
96deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.90308505
97protein localization to kinetochore (GO:0034501)2.87948533
98NLS-bearing protein import into nucleus (GO:0006607)2.87005488
99fatty acid catabolic process (GO:0009062)2.86808952
100hypotonic response (GO:0006971)2.86316127
101regulation of triglyceride catabolic process (GO:0010896)2.84995387
102cilium movement (GO:0003341)2.84637828
103neuronal action potential propagation (GO:0019227)2.84089830
104deoxyribonucleotide biosynthetic process (GO:0009263)2.83768152
105fatty-acyl-CoA metabolic process (GO:0035337)2.83691125
106positive regulation of chromosome segregation (GO:0051984)2.83329575
107alpha-linolenic acid metabolic process (GO:0036109)2.81089507
108motile cilium assembly (GO:0044458)2.79403989
109protein targeting to Golgi (GO:0000042)2.79099921
110angiotensin maturation (GO:0002003)2.76783487
111intestinal epithelial cell development (GO:0060576)2.76197985
112negative regulation of DNA repair (GO:0045738)2.74480133
113modified amino acid transport (GO:0072337)2.73092777
114regulation of microtubule-based movement (GO:0060632)2.73038839
115long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.72247126
116hippo signaling (GO:0035329)2.72236581
117phosphatidic acid biosynthetic process (GO:0006654)2.72121390
118phosphatidic acid metabolic process (GO:0046473)2.72121390
119mitotic spindle organization (GO:0007052)2.71888308
120positive regulation of lipid catabolic process (GO:0050996)2.70205428
121regulation of early endosome to late endosome transport (GO:2000641)2.70175872
122chromosome condensation (GO:0030261)2.66717035
123paraxial mesoderm development (GO:0048339)2.66017688
124glycerol ether metabolic process (GO:0006662)2.66012637
125nucleoside diphosphate biosynthetic process (GO:0009133)2.65885257
126fatty acid oxidation (GO:0019395)2.65358192
127regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.65180557
128regulation of sister chromatid cohesion (GO:0007063)2.64881967
129lipid oxidation (GO:0034440)2.64787313
130nuclear envelope disassembly (GO:0051081)2.64102119
131membrane disassembly (GO:0030397)2.64102119
132acylglycerol catabolic process (GO:0046464)2.63294851
133neutral lipid catabolic process (GO:0046461)2.63294851
134positive regulation of protein autophosphorylation (GO:0031954)2.62730121
135regulation of fatty acid oxidation (GO:0046320)2.61970826
136C4-dicarboxylate transport (GO:0015740)2.61620710
137L-amino acid import (GO:0043092)2.60543498
138epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.59619897
139mitotic nuclear envelope disassembly (GO:0007077)2.59173105
140cell-substrate junction assembly (GO:0007044)2.58478752
141acetyl-CoA metabolic process (GO:0006084)2.57270528
142cytoskeleton-dependent cytokinesis (GO:0061640)2.57145371
143negative regulation of keratinocyte proliferation (GO:0010839)2.56712259
144single fertilization (GO:0007338)2.56689387
145establishment of protein localization to Golgi (GO:0072600)2.56592915
146labyrinthine layer development (GO:0060711)2.56475679
147folic acid transport (GO:0015884)2.55923661
148amino acid transmembrane transport (GO:0003333)2.55621230
149regulation of protein localization to plasma membrane (GO:1903076)2.55572206
150* glycerol metabolic process (GO:0006071)2.54560386
151triglyceride catabolic process (GO:0019433)2.53865932
152mitotic G2 DNA damage checkpoint (GO:0007095)2.53527867
153cellular potassium ion homeostasis (GO:0030007)2.53402167
154spermatogenesis (GO:0007283)2.53024004
155dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.51607576
156mitotic G2/M transition checkpoint (GO:0044818)2.51392623
157positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.51342941
158regulation of RIG-I signaling pathway (GO:0039535)2.50549421
159positive regulation of hormone biosynthetic process (GO:0046886)2.48622562
160attachment of spindle microtubules to kinetochore (GO:0008608)2.48436677
161regulation of mitotic spindle organization (GO:0060236)2.48265073
162keratinocyte proliferation (GO:0043616)2.47769316
163protein export from nucleus (GO:0006611)2.47507989
164negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.47372473
165establishment of integrated proviral latency (GO:0075713)2.46299298
166positive regulation of macroautophagy (GO:0016239)2.45066778
167notochord development (GO:0030903)2.44710527
168regulation of centrosome duplication (GO:0010824)2.44156917
169negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.43167362
170ribosome assembly (GO:0042255)2.42942447
171positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.42848576
172mRNA transcription (GO:0009299)2.41482740
173regulation of glomerular filtration (GO:0003093)2.40644276
174activation of Rac GTPase activity (GO:0032863)2.40634636
175regulation of centrosome cycle (GO:0046605)2.40116815
176vesicle coating (GO:0006901)2.39677543
177iron ion import (GO:0097286)2.39477460
178cytoplasmic mRNA processing body assembly (GO:0033962)2.38268531
179regulation of Rac protein signal transduction (GO:0035020)2.37850233
180DNA duplex unwinding (GO:0032508)2.37541766
181cellular response to thyroid hormone stimulus (GO:0097067)2.37412896
182COPII vesicle coating (GO:0048208)2.37133822
183glycosphingolipid catabolic process (GO:0046479)2.36615569
184DNA packaging (GO:0006323)2.35650931
185DNA strand elongation (GO:0022616)2.35470944
186UDP-N-acetylglucosamine metabolic process (GO:0006047)2.33201078
187positive regulation of cytokinesis (GO:0032467)2.32656054
188cell-cell junction assembly (GO:0007043)2.30399371
189osteoclast differentiation (GO:0030316)2.29957219
190positive regulation of keratinocyte differentiation (GO:0045618)2.29379942
191positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.28644415
192positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.28644415
193positive regulation of mitotic sister chromatid separation (GO:1901970)2.28644415
194regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.26746772
195regulation of keratinocyte differentiation (GO:0045616)2.26288597
196regulation of glucocorticoid metabolic process (GO:0031943)2.25717706
197regulation of chromosome segregation (GO:0051983)2.24263522
198peptidyl-threonine modification (GO:0018210)2.23588477
199non-recombinational repair (GO:0000726)2.22625949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.26588728
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.26140199
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.72571097
4* PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.05829106
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.46370033
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.32159283
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.17670358
8EZH2_22144423_ChIP-Seq_EOC_Human3.15096325
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.07848389
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.05926773
11ZNF274_21170338_ChIP-Seq_K562_Hela2.92721790
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.86637783
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.78154957
14GATA1_22025678_ChIP-Seq_K562_Human2.59375377
15REST_21632747_ChIP-Seq_MESCs_Mouse2.58772025
16ZNF263_19887448_ChIP-Seq_K562_Human2.52972551
17* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.50694176
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.35414480
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.34817642
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.25936665
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.24666871
22VDR_22108803_ChIP-Seq_LS180_Human2.23319814
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.18334904
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.11151696
25PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.04231023
26CLOCK_20551151_ChIP-Seq_293T_Human2.03789509
27* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.02961908
28* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.02961908
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.96718643
30SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.94513282
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91518552
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91190980
33TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.90417246
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89725005
35* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.88350337
36* LXR_22158963_ChIP-Seq_LIVER_Mouse1.83951893
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82458389
38ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.81028893
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.79849067
40SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.75855789
41CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.74772498
42SALL4_18804426_ChIP-ChIP_XEN_Mouse1.74010292
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.72343931
44RXR_22158963_ChIP-Seq_LIVER_Mouse1.72092831
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.72023534
46FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.70949530
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.69452292
48PPARA_22158963_ChIP-Seq_LIVER_Mouse1.64267675
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.62579580
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59872157
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.58116473
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.57602842
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56321070
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56308094
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54330000
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.49446838
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48361295
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47752635
59FOXO3_23340844_ChIP-Seq_DLD1_Human1.46980613
60CTNNB1_20460455_ChIP-Seq_HCT116_Human1.45712031
61* E2F1_21310950_ChIP-Seq_MCF-7_Human1.44220894
62BRD4_25478319_ChIP-Seq_HGPS_Human1.42672172
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.40832377
64KAP1_22055183_ChIP-Seq_ESCs_Mouse1.40250935
65* CBP_20019798_ChIP-Seq_JUKART_Human1.38962523
66* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38962523
67NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.38827699
68SOX9_24532713_ChIP-Seq_HFSC_Mouse1.38287837
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38211373
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38211373
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.37206650
72* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.32848243
73KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.31838269
74ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30941538
75TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.30592527
76* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30313043
77FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.29543079
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29293755
79AHR_22903824_ChIP-Seq_MCF-7_Human1.26665631
80PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.24180018
81GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.23672377
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23123583
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22928125
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22900194
85CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22386350
86FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22022512
87KLF4_19829295_ChIP-Seq_ESCs_Human1.21860634
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21467360
89SOX2_20726797_ChIP-Seq_SW620_Human1.19606304
90RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18977703
91NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17730394
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17210496
93TFEB_21752829_ChIP-Seq_HELA_Human1.15844665
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15718706
95* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15042911
96FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15035604
97CJUN_26792858_Chip-Seq_BT549_Human1.14467000
98FOXH1_21741376_ChIP-Seq_ESCs_Human1.13726583
99SALL1_21062744_ChIP-ChIP_HESCs_Human1.12823201
100* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12264503
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11420997
102SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.10974249
103TP53_22573176_ChIP-Seq_HFKS_Human1.10661319
104* TCF4_18268006_ChIP-ChIP_LS174T_Human1.10648472
105TP53_16413492_ChIP-PET_HCT116_Human1.10224983
106STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09342046
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08744600
108KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07205345
109ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07159109
110FLI1_21867929_ChIP-Seq_TH2_Mouse1.06652972
111POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06563492
112SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06510869
113LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.06417725
114NFE2_27457419_Chip-Seq_LIVER_Mouse1.05981860
115GATA1_26923725_Chip-Seq_HPCs_Mouse1.05800729
116ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05050639
117* TP63_23658742_ChIP-Seq_EP156T_Human1.04011121
118* STAT3_23295773_ChIP-Seq_U87_Human1.03988534
119GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.02992846
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02973158
121* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02180965
122CDX2_22108803_ChIP-Seq_LS180_Human1.01464146
123FUS_26573619_Chip-Seq_HEK293_Human1.00397852
124AR_25329375_ChIP-Seq_VCAP_Human1.00052001
125EP300_21415370_ChIP-Seq_HL-1_Mouse1.00047968
126* NANOG_18555785_Chip-Seq_ESCs_Mouse0.98821194
127TAF15_26573619_Chip-Seq_HEK293_Human0.98817750
128* ARNT_22903824_ChIP-Seq_MCF-7_Human0.98383587
129NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98142437
130* SMAD4_21799915_ChIP-Seq_A2780_Human0.97854370
131SMAD4_21741376_ChIP-Seq_EPCs_Human0.97165560
132* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97021071
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96707752
134MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96579265
135ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96370723
136MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96306088
137* GATA3_24758297_ChIP-Seq_MCF-7_Human0.95799528
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94530497
139* GATA6_25053715_ChIP-Seq_YYC3_Human0.94321159
140* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93990427
141CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93629789
142* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92967797
143PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92695218
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92482532
145* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92327120
146P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91953991
147STAT1_17558387_ChIP-Seq_HELA_Human0.91909055
148NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91690514
149SOX17_20123909_ChIP-Seq_XEN_Mouse0.91589025
150* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91036231
151AR_21909140_ChIP-Seq_LNCAP_Human0.90346201
152GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89207229
153SOX2_22085726_ChIP-Seq_NPCs_Mouse0.88786118
154NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88368858
155TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87659586
156OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87445745
157AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87213784
158CHD1_26751641_Chip-Seq_LNCaP_Human0.87002204
159* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86478096
160TBX20_22080862_ChIP-Seq_HEART_Mouse0.86320971
161TBX20_22328084_ChIP-Seq_HEART_Mouse0.86320971
162FLI1_21867929_ChIP-Seq_CD8_Mouse0.85763270
163* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85573037
164NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.84967188
165ATF3_27146783_Chip-Seq_COLON_Human0.84792933
166GF1B_26923725_Chip-Seq_HPCs_Mouse0.83847370
167HTT_18923047_ChIP-ChIP_STHdh_Human0.83722187
168WDR5_24793694_ChIP-Seq_LNCAP_Human0.83676092
169* SOX2_18555785_Chip-Seq_ESCs_Mouse0.83481414
170TP53_18474530_ChIP-ChIP_U2OS_Human0.83455119
171PU_27001747_Chip-Seq_BMDM_Mouse0.83402177
172* CMYC_18555785_Chip-Seq_ESCs_Mouse0.83382527
173* NANOG_16518401_ChIP-PET_MESCs_Mouse0.82184283
174* P53_22387025_ChIP-Seq_ESCs_Mouse0.81973632
175SMAD3_21741376_ChIP-Seq_EPCs_Human0.81653137
176STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.81577679
177CRX_20693478_ChIP-Seq_RETINA_Mouse0.81267896
178* P300_18555785_Chip-Seq_ESCs_Mouse0.81034193
179BCAT_22108803_ChIP-Seq_LS180_Human0.80986369
180NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.80876157
181SMAD1_18555785_Chip-Seq_ESCs_Mouse0.80868125
182ER_23166858_ChIP-Seq_MCF-7_Human0.80862124
183PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80603063
184* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.79915310
185AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79681475
186JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.79433120

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.88132033
2MP0010352_gastrointestinal_tract_polyps4.87836028
3MP0004859_abnormal_synaptic_plasticity3.81168611
4MP0005670_abnormal_white_adipose3.54816810
5MP0003705_abnormal_hypodermis_morpholog3.46304100
6MP0003329_amyloid_beta_deposits3.32843988
7MP0004270_analgesia3.30441606
8MP0008057_abnormal_DNA_replication2.99601900
9MP0010678_abnormal_skin_adnexa2.99016447
10MP0004043_abnormal_pH_regulation2.78793171
11MP0003941_abnormal_skin_development2.67604760
12MP0003566_abnormal_cell_adhesion2.54415768
13MP0005360_urolithiasis2.50395912
14MP0002796_impaired_skin_barrier2.48992596
15MP0003950_abnormal_plasma_membrane2.43666762
16MP0004957_abnormal_blastocyst_morpholog2.42480389
17MP0003453_abnormal_keratinocyte_physiol2.41064396
18MP0000383_abnormal_hair_follicle2.37417832
19MP0005666_abnormal_adipose_tissue2.34310448
20MP0000013_abnormal_adipose_tissue2.30484129
21MP0010329_abnormal_lipoprotein_level2.24919334
22MP0004130_abnormal_muscle_cell2.23568902
23MP0002139_abnormal_hepatobiliary_system2.22018269
24MP0003646_muscle_fatigue2.20555292
25MP0005451_abnormal_body_composition2.16450917
26MP0003635_abnormal_synaptic_transmissio2.10782414
27MP0003880_abnormal_central_pattern2.08443750
28MP0010094_abnormal_chromosome_stability2.06773139
29MP0000604_amyloidosis2.06432406
30MP0003191_abnormal_cellular_cholesterol2.06137829
31* MP0005535_abnormal_body_temperature2.05058823
32MP0003698_abnormal_male_reproductive2.04510763
33MP0010307_abnormal_tumor_latency2.01690842
34* MP0002971_abnormal_brown_adipose2.01520150
35MP0009840_abnormal_foam_cell1.91412089
36* MP0002118_abnormal_lipid_homeostasis1.88442816
37MP0009780_abnormal_chondrocyte_physiolo1.82156260
38MP0005248_abnormal_Harderian_gland1.78585531
39MP0005375_adipose_tissue_phenotype1.76329027
40MP0005365_abnormal_bile_salt1.72382214
41MP0006036_abnormal_mitochondrial_physio1.72056780
42MP0001929_abnormal_gametogenesis1.71746508
43MP0005085_abnormal_gallbladder_physiolo1.71063545
44MP0008260_abnormal_autophagy1.70473407
45MP0003091_abnormal_cell_migration1.68758033
46* MP0005332_abnormal_amino_acid1.66855085
47MP0002063_abnormal_learning/memory/cond1.66340253
48MP0009046_muscle_twitch1.66004766
49MP0001501_abnormal_sleep_pattern1.64536309
50MP0003806_abnormal_nucleotide_metabolis1.64421845
51MP0004185_abnormal_adipocyte_glucose1.63829620
52MP0000569_abnormal_digit_pigmentation1.61375094
53MP0005257_abnormal_intraocular_pressure1.61207423
54MP0003111_abnormal_nucleus_morphology1.60706736
55MP0003077_abnormal_cell_cycle1.60706370
56MP0005501_abnormal_skin_physiology1.57708722
57* MP0002078_abnormal_glucose_homeostasis1.57496600
58MP0000003_abnormal_adipose_tissue1.53935731
59MP0009745_abnormal_behavioral_response1.49026932
60MP0001440_abnormal_grooming_behavior1.48854869
61MP0001216_abnormal_epidermal_layer1.48246795
62MP0005076_abnormal_cell_differentiation1.47254661
63MP0001666_abnormal_nutrient_absorption1.46086306
64MP0002837_dystrophic_cardiac_calcinosis1.45831579
65MP0003690_abnormal_glial_cell1.43138374
66MP0002909_abnormal_adrenal_gland1.42693280
67MP0000579_abnormal_nail_morphology1.41931142
68MP0002064_seizures1.41780996
69MP0002060_abnormal_skin_morphology1.40948815
70MP0000627_abnormal_mammary_gland1.39505910
71MP0002876_abnormal_thyroid_physiology1.39344038
72MP0004145_abnormal_muscle_electrophysio1.37153006
73MP0005167_abnormal_blood-brain_barrier1.35078419
74MP0001661_extended_life_span1.34668934
75MP0008932_abnormal_embryonic_tissue1.34119086
76MP0002734_abnormal_mechanical_nocicepti1.33572726
77MP0001730_embryonic_growth_arrest1.32598949
78MP0001849_ear_inflammation1.31407136
79MP0009697_abnormal_copulation1.29021234
80MP0001486_abnormal_startle_reflex1.28335175
81MP0000377_abnormal_hair_follicle1.27956732
82MP0010234_abnormal_vibrissa_follicle1.27494155
83MP0001765_abnormal_ion_homeostasis1.27413408
84MP0002272_abnormal_nervous_system1.26433812
85MP0002572_abnormal_emotion/affect_behav1.25739304
86MP0003633_abnormal_nervous_system1.24886808
87MP0003828_pulmonary_edema1.24646226
88MP0005409_darkened_coat_color1.24430862
89MP0000350_abnormal_cell_proliferation1.23948212
90MP0005448_abnormal_energy_balance1.23524603
91* MP0002161_abnormal_fertility/fecundity1.21038967
92MP0002098_abnormal_vibrissa_morphology1.19073965
93* MP0002693_abnormal_pancreas_physiology1.18313346
94MP0003195_calcinosis1.17328127
95MP0004233_abnormal_muscle_weight1.14250366
96MP0003693_abnormal_embryo_hatching1.13278340
97MP0000427_abnormal_hair_cycle1.12290022
98MP0003631_nervous_system_phenotype1.11805524
99MP0003448_altered_tumor_morphology1.11639178
100MP0002822_catalepsy1.11152636
101MP0004264_abnormal_extraembryonic_tissu1.10533968
102MP0005621_abnormal_cell_physiology1.08769742
103MP0002877_abnormal_melanocyte_morpholog1.07676030
104* MP0000609_abnormal_liver_physiology1.07519809
105MP0005408_hypopigmentation1.06075089
106MP0004019_abnormal_vitamin_homeostasis1.05924967
107MP0000747_muscle_weakness1.05172759
108MP0005584_abnormal_enzyme/coenzyme_acti1.04921377
109MP0002896_abnormal_bone_mineralization1.04428858
110MP0003879_abnormal_hair_cell1.04324742
111* MP0005334_abnormal_fat_pad1.04320281
112MP0003890_abnormal_embryonic-extraembry1.03511716
113MP0001944_abnormal_pancreas_morphology1.02137100
114MP0008872_abnormal_physiological_respon1.01880906
115MP0004885_abnormal_endolymph0.99992161
116MP0001968_abnormal_touch/_nociception0.99527895
117MP0003718_maternal_effect0.98756627
118MP0002086_abnormal_extraembryonic_tissu0.98711171
119MP0003632_abnormal_nervous_system0.97987425
120MP0005379_endocrine/exocrine_gland_phen0.97497298
121MP0001672_abnormal_embryogenesis/_devel0.97408618
122MP0005380_embryogenesis_phenotype0.97408618
123* MP0003953_abnormal_hormone_level0.96665119
124MP0001764_abnormal_homeostasis0.95632660
125MP0006035_abnormal_mitochondrial_morpho0.95563845
126MP0010771_integument_phenotype0.95091230
127MP0002733_abnormal_thermal_nociception0.94446239
128MP0002009_preneoplasia0.93918226
129MP0005023_abnormal_wound_healing0.90267937
130MP0008569_lethality_at_weaning0.90004956
131MP0000733_abnormal_muscle_development0.89751237
132MP0008007_abnormal_cellular_replicative0.89529768
133MP0003183_abnormal_peptide_metabolism0.89399449
134MP0000428_abnormal_craniofacial_morphol0.89312154
135MP0003221_abnormal_cardiomyocyte_apopto0.89067177
136MP0002090_abnormal_vision0.88499131
137MP0006138_congestive_heart_failure0.88037440
138MP0001697_abnormal_embryo_size0.87414647
139MP0002269_muscular_atrophy0.87383468
140MP0005266_abnormal_metabolism0.87173436
141MP0008877_abnormal_DNA_methylation0.86964605
142MP0009672_abnormal_birth_weight0.86589037
143MP0000749_muscle_degeneration0.86513181
144MP0005623_abnormal_meninges_morphology0.86508303
145MP0008875_abnormal_xenobiotic_pharmacok0.86358323
146MP0003984_embryonic_growth_retardation0.85743993
147MP0005386_behavior/neurological_phenoty0.85456656
148MP0004924_abnormal_behavior0.85456656
149* MP0005319_abnormal_enzyme/_coenzyme0.84286837
150MP0005165_increased_susceptibility_to0.83664223
151MP0005384_cellular_phenotype0.83329978
152MP0000462_abnormal_digestive_system0.82987969
153MP0002088_abnormal_embryonic_growth/wei0.82038731
154MP0009643_abnormal_urine_homeostasis0.81872598
155MP0004036_abnormal_muscle_relaxation0.81165651
156* MP0002080_prenatal_lethality0.80861737
157MP0002736_abnormal_nociception_after0.80532320
158MP0004272_abnormal_basement_membrane0.80462508
159MP0005197_abnormal_uvea_morphology0.80429024
160MP0003303_peritoneal_inflammation0.79907896
161MP0001881_abnormal_mammary_gland0.78966894
162* MP0009115_abnormal_fat_cell0.78874410
163MP0001191_abnormal_skin_condition0.78719308
164MP0004510_myositis0.76489395
165MP0000647_abnormal_sebaceous_gland0.75512922
166MP0005058_abnormal_lysosome_morphology0.75430163
167MP0004808_abnormal_hematopoietic_stem0.75224755
168MP0005647_abnormal_sex_gland0.74696030
169MP0002332_abnormal_exercise_endurance0.74493076
170* MP0005452_abnormal_adipose_tissue0.74079562
171MP0002067_abnormal_sensory_capabilities0.74072130
172MP0002066_abnormal_motor_capabilities/c0.73680764
173MP0003656_abnormal_erythrocyte_physiolo0.73575037
174MP0000015_abnormal_ear_pigmentation0.73569166
175MP0001851_eye_inflammation0.73343848
176MP0005636_abnormal_mineral_homeostasis0.72771162
177MP0001145_abnormal_male_reproductive0.72241582
178MP0004087_abnormal_muscle_fiber0.72209322
179MP0004858_abnormal_nervous_system0.72189758
180MP0003075_altered_response_to0.72059910
181MP0008004_abnormal_stomach_pH0.71757342
182MP0004197_abnormal_fetal_growth/weight/0.70545847
183MP0000358_abnormal_cell_content/0.70162571
184MP0006054_spinal_hemorrhage0.69685986
185MP0005464_abnormal_platelet_physiology0.68981978
186MP0001299_abnormal_eye_distance/0.68142810

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)5.35356746
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.19556332
3Absent/shortened dynein arms (HP:0200106)5.19556332
4Abnormality of glycine metabolism (HP:0010895)4.46438624
5Abnormality of serine family amino acid metabolism (HP:0010894)4.46438624
6Hypoglycemic coma (HP:0001325)4.44462805
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.32899225
8Hyperglycinemia (HP:0002154)4.24484775
9Insulin-resistant diabetes mellitus (HP:0000831)4.01219104
10Papillary thyroid carcinoma (HP:0002895)3.91521874
11Osteolytic defects of the hand bones (HP:0009699)3.86566621
12Osteolytic defects of the phalanges of the hand (HP:0009771)3.86566621
13Focal motor seizures (HP:0011153)3.75244641
14Myoglobinuria (HP:0002913)3.68877106
15Hyperinsulinemic hypoglycemia (HP:0000825)3.56085012
16Global brain atrophy (HP:0002283)3.43841283
17Abnormal respiratory epithelium morphology (HP:0012253)3.40480721
18Abnormal respiratory motile cilium morphology (HP:0005938)3.40480721
19Chromsome breakage (HP:0040012)3.35321678
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.34036458
21Ankyloglossia (HP:0010296)3.29379057
22Cerebral inclusion bodies (HP:0100314)3.26564423
23Hyperglycemia (HP:0003074)3.23881874
24Neurofibrillary tangles (HP:0002185)3.16790082
25Rhabdomyolysis (HP:0003201)3.15241894
26Abnormality of oral frenula (HP:0000190)3.03091984
27Right ventricular cardiomyopathy (HP:0011663)3.00631272
28Chronic bronchitis (HP:0004469)3.00287375
29Spastic tetraparesis (HP:0001285)2.92758747
30Abnormal respiratory motile cilium physiology (HP:0012261)2.92133926
31Nemaline bodies (HP:0003798)2.81821314
32Subacute progressive viral hepatitis (HP:0006572)2.81221152
33Exercise-induced myalgia (HP:0003738)2.81195792
34Infertility (HP:0000789)2.77176696
35Visual hallucinations (HP:0002367)2.76659759
36Hypoglycemic seizures (HP:0002173)2.74092950
37Progressive external ophthalmoplegia (HP:0000590)2.74023939
38Tetraplegia (HP:0002445)2.73879604
39Short nail (HP:0001799)2.70878248
40Volvulus (HP:0002580)2.66195876
41Abnormality of dicarboxylic acid metabolism (HP:0010995)2.65709390
42Dicarboxylic aciduria (HP:0003215)2.65709390
43Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.63003124
44Leiomyosarcoma (HP:0100243)2.61818006
45Uterine leiomyosarcoma (HP:0002891)2.61818006
46Thyroid carcinoma (HP:0002890)2.61783318
47Ketoacidosis (HP:0001993)2.61210006
48Bundle branch block (HP:0011710)2.58967247
49Absent frontal sinuses (HP:0002688)2.57512169
50Muscle fiber inclusion bodies (HP:0100299)2.53335828
51Gout (HP:0001997)2.52538915
52Rhinitis (HP:0012384)2.51960580
53Distal lower limb amyotrophy (HP:0008944)2.51349988
54Abnormality of fatty-acid metabolism (HP:0004359)2.51293828
55Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.50151436
56Transitional cell carcinoma of the bladder (HP:0006740)2.48538030
57Deep philtrum (HP:0002002)2.48378066
58Ketosis (HP:0001946)2.45533724
59Autoamputation (HP:0001218)2.44248645
60Gastrointestinal carcinoma (HP:0002672)2.43983263
61Malignant gastrointestinal tract tumors (HP:0006749)2.43983263
62Difficulty running (HP:0009046)2.42192017
63Male infertility (HP:0003251)2.42179171
64Hyperammonemia (HP:0001987)2.40683879
65Abnormal auditory evoked potentials (HP:0006958)2.39213078
66Urethral obstruction (HP:0000796)2.38439687
67Microglossia (HP:0000171)2.37792015
68Tetraparesis (HP:0002273)2.37290299
69Delusions (HP:0000746)2.36830424
70Glucose intolerance (HP:0000833)2.36244895
71Insulin resistance (HP:0000855)2.33868614
72Bladder neoplasm (HP:0009725)2.33712582
73Bladder carcinoma (HP:0002862)2.33712582
74Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.31715663
75Hyperventilation (HP:0002883)2.30032179
76Hypobetalipoproteinemia (HP:0003563)2.29192726
77Abnormality of serum amino acid levels (HP:0003112)2.28354049
78Hydroxyprolinuria (HP:0003080)2.26730546
79Abnormality of proline metabolism (HP:0010907)2.26730546
80Increased mean platelet volume (HP:0011877)2.26430738
81Focal seizures (HP:0007359)2.25548803
82Methylmalonic aciduria (HP:0012120)2.25521526
83Confusion (HP:0001289)2.23737547
84Athetosis (HP:0002305)2.23361374
85Curly hair (HP:0002212)2.22510994
86Lower limb amyotrophy (HP:0007210)2.18966789
87Vertebral arch anomaly (HP:0008438)2.18558150
88Abnormality of glycolipid metabolism (HP:0010969)2.18466169
89Abnormality of liposaccharide metabolism (HP:0010968)2.18466169
90Abnormality of glycosphingolipid metabolism (HP:0004343)2.18466169
91Urinary bladder sphincter dysfunction (HP:0002839)2.18259204
92Dialeptic seizures (HP:0011146)2.17778972
93Impaired vibration sensation in the lower limbs (HP:0002166)2.17400761
94Hemiparesis (HP:0001269)2.16206691
95Distal lower limb muscle weakness (HP:0009053)2.16026980
96Abnormal ciliary motility (HP:0012262)2.15660510
97Selective tooth agenesis (HP:0001592)2.14873858
98Scanning speech (HP:0002168)2.14801318
99Impulsivity (HP:0100710)2.14413186
100Irritability (HP:0000737)2.13998358
101Rhabdomyosarcoma (HP:0002859)2.12146043
102Oligomenorrhea (HP:0000876)2.11139477
103Abnormal glucose tolerance (HP:0001952)2.10900944
104Termporal pattern (HP:0011008)2.10725822
105Insidious onset (HP:0003587)2.10725822
106Medulloblastoma (HP:0002885)2.10089632
107Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.09983132
108Hypolipoproteinemia (HP:0010981)2.09671994
109Spinal cord lesions (HP:0100561)2.09018534
110Syringomyelia (HP:0003396)2.09018534
111Exercise-induced muscle cramps (HP:0003710)2.08281978
112Absence seizures (HP:0002121)2.06138749
113Periodontitis (HP:0000704)2.04301270
114Symptomatic seizures (HP:0011145)2.04039558
115Uterine neoplasm (HP:0010784)2.03883975
116Biliary tract neoplasm (HP:0100574)2.01938867
117Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.01631762
118Xanthomatosis (HP:0000991)2.00955524
119Micronodular cirrhosis (HP:0001413)1.98846764
120Lethargy (HP:0001254)1.97391212
121Increased purine levels (HP:0004368)1.96249279
122Hyperuricemia (HP:0002149)1.96249279
123Abnormality of the lower motor neuron (HP:0002366)1.96202723
124Dysautonomia (HP:0002459)1.96083868
125Limb hypertonia (HP:0002509)1.95839293
126Restlessness (HP:0000711)1.95219095
127Relative macrocephaly (HP:0004482)1.94714574
128Difficulty climbing stairs (HP:0003551)1.93307260
129Hyperkalemia (HP:0002153)1.93297200
130Abnormality of chromosome stability (HP:0003220)1.92985593
131Abnormality of the distal phalanges of the toes (HP:0010182)1.92921546
132Neoplasm of the small intestine (HP:0100833)1.92820027
133Orthostatic hypotension (HP:0001278)1.92682497
134Generalized tonic-clonic seizures (HP:0002069)1.90736072
135Dysmetric saccades (HP:0000641)1.90376018
136Epileptic encephalopathy (HP:0200134)1.90145592
137Impaired smooth pursuit (HP:0007772)1.89398708
138Abnormality of glutamine family amino acid metabolism (HP:0010902)1.89057004
139Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88648711
140Abnormality of alanine metabolism (HP:0010916)1.88648711
141Hyperalaninemia (HP:0003348)1.88648711
142Atonic seizures (HP:0010819)1.88484522
143Neurodegeneration (HP:0002180)1.88444234
144Abnormal platelet volume (HP:0011876)1.86514579
145Renal cell carcinoma (HP:0005584)1.85569325
146Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.84925654
147Abnormality of purine metabolism (HP:0004352)1.84561482
148Resting tremor (HP:0002322)1.84310044
149Myocardial infarction (HP:0001658)1.83442920
150Increased nuchal translucency (HP:0010880)1.82798845
151Ileus (HP:0002595)1.82746782
152Pheochromocytoma (HP:0002666)1.82575777
153Impaired social interactions (HP:0000735)1.81554952
154Abnormal social behavior (HP:0012433)1.81554952
155Hypoalphalipoproteinemia (HP:0003233)1.79822890
156Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.78802692
157Abnormality of the corticospinal tract (HP:0002492)1.78607291
158Increased connective tissue (HP:0009025)1.78143948
159Progressive sensorineural hearing impairment (HP:0000408)1.77768415
160Generalized aminoaciduria (HP:0002909)1.77199075
161Acute myeloid leukemia (HP:0004808)1.76934782
162Myopathic facies (HP:0002058)1.76521687
163Supranuclear gaze palsy (HP:0000605)1.76473812
164Subaortic stenosis (HP:0001682)1.76303762
165Abnormality of the left ventricular outflow tract (HP:0011103)1.76303762
166Centrally nucleated skeletal muscle fibers (HP:0003687)1.76253936
167Deviation of the thumb (HP:0009603)1.76136236
168Morphological abnormality of the pyramidal tract (HP:0002062)1.74451360
169Thick nail (HP:0001805)1.74078250
170Apathy (HP:0000741)1.72669945
171Abnormality of the salivary glands (HP:0010286)1.72450994
172Progressive cerebellar ataxia (HP:0002073)1.72388562
173Abnormality of vitamin B metabolism (HP:0004340)1.71702607
174Glioma (HP:0009733)1.71548107
175Abnormality of vision evoked potentials (HP:0000649)1.71297711
176Abnormality of the astrocytes (HP:0100707)1.70935593
177Astrocytoma (HP:0009592)1.70935593
178Abnormality of the preputium (HP:0100587)1.70510448
179Flat acetabular roof (HP:0003180)1.69419425
180Freckling (HP:0001480)1.67019416
181Neoplasm of the thyroid gland (HP:0100031)1.66540027
182Aplasia cutis congenita (HP:0001057)1.66091178
183Pelvic girdle muscle weakness (HP:0003749)1.65800272
184Progressive hearing impairment (HP:0001730)1.64733555
185Large earlobe (HP:0009748)1.62960505
186Milia (HP:0001056)1.62743191
187Bone pain (HP:0002653)1.61240097
188Natal tooth (HP:0000695)1.60027438
189Axonal loss (HP:0003447)1.58558297
190Hyperacusis (HP:0010780)1.58145261
191Decreased motor nerve conduction velocity (HP:0003431)1.57557241
192Malnutrition (HP:0004395)1.57313578
193Proximal placement of thumb (HP:0009623)1.57166039
194Cystic hygroma (HP:0000476)1.55773071

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.51101794
2PDK46.51101794
3PDK24.55310521
4PNCK3.63950753
5PRKD33.53787537
6SCYL23.22492905
7EPHA42.99315774
8MST42.46562176
9NTRK32.44827366
10RIPK42.41384128
11MET2.39772249
12AKT32.33962059
13BCKDK2.15421285
14MAP3K92.01386974
15MAP3K121.97094394
16PLK41.92123819
17TTN1.76951055
18MAP3K21.55290720
19KSR21.54365855
20YES11.54194511
21EPHA21.53629929
22TRIM281.53568843
23FRK1.53292128
24WEE11.49944851
25STK241.47572042
26PDGFRA1.44786109
27INSRR1.44201437
28TESK11.44162658
29CAMK1G1.43040997
30EIF2AK11.40471681
31ARAF1.39417467
32CDC71.38035292
33PAK41.37864511
34ERBB41.36456594
35PDPK11.35021625
36NME11.33910756
37PDK11.27582804
38STK38L1.21009740
39NEK11.19237802
40ERBB31.18043321
41STK31.17700874
42IRAK21.15468523
43BUB11.15233819
44CAMK1D1.14780159
45NEK91.14157725
46STK381.11774736
47MINK11.11082175
48TRPM71.10886222
49EEF2K1.06677947
50TSSK61.05560128
51SIK31.03091526
52PTK2B1.00550665
53ACVR1B0.99076912
54LATS10.96354094
55STK390.93683658
56MAP2K40.93474647
57ALK0.93105924
58OBSCN0.91251914
59NTRK10.90932546
60PRKCG0.89800024
61PAK60.89795613
62IRAK30.89261339
63BRD40.89082345
64STK100.88911410
65TTK0.87666080
66PASK0.86356058
67RIPK10.85636285
68CDK60.84303167
69DAPK20.83211105
70LMTK20.83000194
71BMX0.82520869
72MAP3K40.82427685
73MELK0.82392176
74NME20.82287818
75MAP3K30.82102200
76ROCK20.79333952
77RPS6KB20.77771512
78MARK10.76772732
79PINK10.76617599
80PDGFRB0.76370213
81PTK20.76343394
82CAMKK10.75490388
83CDK120.75225295
84MAP3K130.74849014
85MAP3K80.71671497
86PLK20.68634404
87DMPK0.66109344
88BRSK10.65746735
89KSR10.64071705
90PLK30.63107669
91MAP2K10.63101305
92CDK50.60953900
93BRSK20.60041330
94WNK40.58243293
95MAPKAPK30.57302937
96CAMK2B0.56349079
97BMPR20.54035422
98ICK0.53635580
99MAP3K10.52349012
100CAMKK20.51365318
101TRIB30.51297300
102MAP3K140.51012938
103SRPK10.50853948
104FGFR10.50176736
105RAF10.49722072
106CCNB10.49610665
107MKNK10.49284408
108PRKAA10.49195560
109BRAF0.48124363
110AKT20.46513643
111PBK0.44053601
112AURKB0.42033412
113FGR0.42004161
114PRKAA20.41648995
115CAMK2A0.40950771
116PIK3CG0.40533641
117PKN20.40429141
118OXSR10.39913824
119CDK140.39753751
120TAF10.38564359
121MST1R0.38181411
122MOS0.38138245
123PRKG20.38111913
124PRKACG0.36437328
125RPS6KA40.36412702
126FER0.36332807
127PHKG10.35789987
128PHKG20.35789987
129CAMK2G0.35679792
130MTOR0.35583862
131RPS6KA30.35457433
132EIF2AK20.35409709
133GRK50.35240209
134TYK20.35099041
135NEK60.34283636
136DAPK10.34202579
137CAMK2D0.33554326
138WNK30.33299638
139CSNK1E0.33228791
140NEK20.33162983
141PAK20.31793696
142RPS6KB10.31766228
143MAP2K70.31674016
144CDK150.31439952
145MAP2K60.31189756
146CSNK1A10.30731766
147PRKCZ0.30597831
148STK110.30523097
149JAK10.30426531
150MAPK100.30419420
151CHEK20.29551301
152TAOK20.29456115
153CDK70.29381904
154CHEK10.28239954
155CDK180.27731819
156EIF2AK30.27008206
157MAP3K50.26214635
158BCR0.25884127
159LATS20.24675664
160PRKCE0.24615730
161SGK10.24512631
162PLK10.23635237

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.52112769
2Vitamin B6 metabolism_Homo sapiens_hsa007503.29572923
3Fatty acid biosynthesis_Homo sapiens_hsa000613.23378151
4Propanoate metabolism_Homo sapiens_hsa006403.01641099
5Nitrogen metabolism_Homo sapiens_hsa009102.75747286
6Fatty acid metabolism_Homo sapiens_hsa012122.71519162
7Fatty acid degradation_Homo sapiens_hsa000712.52675320
8Adherens junction_Homo sapiens_hsa045202.40455634
9Thyroid cancer_Homo sapiens_hsa052162.33692984
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.25229725
11PPAR signaling pathway_Homo sapiens_hsa033202.16185147
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.13660002
13Fat digestion and absorption_Homo sapiens_hsa049751.97028185
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94725810
15Pyruvate metabolism_Homo sapiens_hsa006201.93045265
16Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.88893575
17Carbon metabolism_Homo sapiens_hsa012001.85000793
18Cell cycle_Homo sapiens_hsa041101.81879495
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.80867991
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80251720
21Glycerolipid metabolism_Homo sapiens_hsa005611.79536805
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.74357423
23Non-homologous end-joining_Homo sapiens_hsa034501.70339084
24Carbohydrate digestion and absorption_Homo sapiens_hsa049731.70039939
25* Glycerophospholipid metabolism_Homo sapiens_hsa005641.69294946
26Renal cell carcinoma_Homo sapiens_hsa052111.63057484
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.61710187
28Glucagon signaling pathway_Homo sapiens_hsa049221.61619049
29Mineral absorption_Homo sapiens_hsa049781.61204969
30Fructose and mannose metabolism_Homo sapiens_hsa000511.61203533
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.59949851
32Long-term potentiation_Homo sapiens_hsa047201.59896383
33Insulin secretion_Homo sapiens_hsa049111.54233705
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.53303837
35Endometrial cancer_Homo sapiens_hsa052131.52007446
36Proteoglycans in cancer_Homo sapiens_hsa052051.45692987
37Sulfur metabolism_Homo sapiens_hsa009201.45542510
38Amphetamine addiction_Homo sapiens_hsa050311.44650667
39Butanoate metabolism_Homo sapiens_hsa006501.41546157
40Small cell lung cancer_Homo sapiens_hsa052221.40812519
41Pancreatic cancer_Homo sapiens_hsa052121.39623442
42DNA replication_Homo sapiens_hsa030301.39476810
43Sphingolipid metabolism_Homo sapiens_hsa006001.38853678
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.38674152
45Chronic myeloid leukemia_Homo sapiens_hsa052201.36732581
46Mismatch repair_Homo sapiens_hsa034301.33567188
47MicroRNAs in cancer_Homo sapiens_hsa052061.32307575
48Vitamin digestion and absorption_Homo sapiens_hsa049771.32007671
49Fatty acid elongation_Homo sapiens_hsa000621.28435867
50Bile secretion_Homo sapiens_hsa049761.27397822
51Salivary secretion_Homo sapiens_hsa049701.23609646
52Pentose phosphate pathway_Homo sapiens_hsa000301.23048915
53Type II diabetes mellitus_Homo sapiens_hsa049301.19275753
54Focal adhesion_Homo sapiens_hsa045101.18880757
55Nicotine addiction_Homo sapiens_hsa050331.18177343
56Amoebiasis_Homo sapiens_hsa051461.13081636
57Lysosome_Homo sapiens_hsa041421.12289877
58Tight junction_Homo sapiens_hsa045301.11387754
59Dorso-ventral axis formation_Homo sapiens_hsa043201.11140004
60Gastric acid secretion_Homo sapiens_hsa049711.08857449
61Glioma_Homo sapiens_hsa052141.08679466
62Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07866124
63Folate biosynthesis_Homo sapiens_hsa007901.07209579
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03376360
65Oocyte meiosis_Homo sapiens_hsa041141.02521848
66Circadian entrainment_Homo sapiens_hsa047131.01491372
67Bladder cancer_Homo sapiens_hsa052191.01469452
68Leukocyte transendothelial migration_Homo sapiens_hsa046701.01376653
69Renin-angiotensin system_Homo sapiens_hsa046141.00953485
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00845511
71Gap junction_Homo sapiens_hsa045400.99539216
72Prostate cancer_Homo sapiens_hsa052150.99324652
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99154839
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98842761
75Starch and sucrose metabolism_Homo sapiens_hsa005000.98268646
76Biosynthesis of amino acids_Homo sapiens_hsa012300.96948382
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96884232
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.96315198
79Non-small cell lung cancer_Homo sapiens_hsa052230.95447035
80Glutamatergic synapse_Homo sapiens_hsa047240.95383493
81Glutathione metabolism_Homo sapiens_hsa004800.95136666
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94227355
83ErbB signaling pathway_Homo sapiens_hsa040120.93856518
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92675387
85Salmonella infection_Homo sapiens_hsa051320.92084663
86Renin secretion_Homo sapiens_hsa049240.91048890
87TGF-beta signaling pathway_Homo sapiens_hsa043500.90338564
88RNA transport_Homo sapiens_hsa030130.89553441
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87093865
90Synaptic vesicle cycle_Homo sapiens_hsa047210.85818952
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84189637
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84071676
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83514905
94Viral carcinogenesis_Homo sapiens_hsa052030.83451868
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82820193
96Galactose metabolism_Homo sapiens_hsa000520.82788595
97GABAergic synapse_Homo sapiens_hsa047270.82390541
98ECM-receptor interaction_Homo sapiens_hsa045120.82099659
99Platelet activation_Homo sapiens_hsa046110.80816245
100p53 signaling pathway_Homo sapiens_hsa041150.80592843
101Prolactin signaling pathway_Homo sapiens_hsa049170.80112236
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.79576002
103AMPK signaling pathway_Homo sapiens_hsa041520.78032814
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77911297
105Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77483845
106Hippo signaling pathway_Homo sapiens_hsa043900.76324525
107Legionellosis_Homo sapiens_hsa051340.75709141
108Thyroid hormone synthesis_Homo sapiens_hsa049180.75184589
109Colorectal cancer_Homo sapiens_hsa052100.74616965
110Shigellosis_Homo sapiens_hsa051310.73304203
111Regulation of autophagy_Homo sapiens_hsa041400.72707764
112Endocytosis_Homo sapiens_hsa041440.72439468
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71392971
114Nucleotide excision repair_Homo sapiens_hsa034200.70621237
115HIF-1 signaling pathway_Homo sapiens_hsa040660.70515484
116Selenocompound metabolism_Homo sapiens_hsa004500.69992224
117Hepatitis C_Homo sapiens_hsa051600.69843987
118Vibrio cholerae infection_Homo sapiens_hsa051100.68712063
119Arginine biosynthesis_Homo sapiens_hsa002200.68307892
120Dopaminergic synapse_Homo sapiens_hsa047280.66454725
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65703766
122Hepatitis B_Homo sapiens_hsa051610.65413228
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.64949021
124Pancreatic secretion_Homo sapiens_hsa049720.64776733
125mTOR signaling pathway_Homo sapiens_hsa041500.64636817
126mRNA surveillance pathway_Homo sapiens_hsa030150.63118885
127Pathways in cancer_Homo sapiens_hsa052000.62891719
128Calcium signaling pathway_Homo sapiens_hsa040200.62057026
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.61692946
130Estrogen signaling pathway_Homo sapiens_hsa049150.60914953
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60165267
132Peroxisome_Homo sapiens_hsa041460.59780302
133Apoptosis_Homo sapiens_hsa042100.59398116
134Long-term depression_Homo sapiens_hsa047300.59365631
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58844512
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.58257928
137Taste transduction_Homo sapiens_hsa047420.57446085
138Fanconi anemia pathway_Homo sapiens_hsa034600.55771265
139Choline metabolism in cancer_Homo sapiens_hsa052310.54720933
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54566032
141Circadian rhythm_Homo sapiens_hsa047100.52995141
142beta-Alanine metabolism_Homo sapiens_hsa004100.52382092
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52072833
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51747481
145Insulin signaling pathway_Homo sapiens_hsa049100.51413841
146Insulin resistance_Homo sapiens_hsa049310.50965821
147Alcoholism_Homo sapiens_hsa050340.50885387
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50403445
149Morphine addiction_Homo sapiens_hsa050320.49655557
150Melanoma_Homo sapiens_hsa052180.49228461
151Rap1 signaling pathway_Homo sapiens_hsa040150.49135721
152Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48893081
153Linoleic acid metabolism_Homo sapiens_hsa005910.47949224
154Tryptophan metabolism_Homo sapiens_hsa003800.45667331
155Type I diabetes mellitus_Homo sapiens_hsa049400.45524098
156Cocaine addiction_Homo sapiens_hsa050300.43934772
157Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42284888
158Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41651844
159Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40849101
160Oxytocin signaling pathway_Homo sapiens_hsa049210.40809812
161Primary bile acid biosynthesis_Homo sapiens_hsa001200.40165347
162Collecting duct acid secretion_Homo sapiens_hsa049660.38668798
163GnRH signaling pathway_Homo sapiens_hsa049120.37782782
164Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37744075
165Metabolic pathways_Homo sapiens_hsa011000.36620239
166Inositol phosphate metabolism_Homo sapiens_hsa005620.36572880
167cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35253992
168Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34523654
169cAMP signaling pathway_Homo sapiens_hsa040240.33672567
170Purine metabolism_Homo sapiens_hsa002300.32923538
171Ether lipid metabolism_Homo sapiens_hsa005650.30731530

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »