GPER1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1coronary vasculature morphogenesis (GO:0060977)6.49676174
2lymph vessel development (GO:0001945)5.59909283
3Notch signaling involved in heart development (GO:0061314)5.57125678
4negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.38988118
5mesenchymal cell development (GO:0014031)5.27501515
6ventricular trabecula myocardium morphogenesis (GO:0003222)5.22335035
7focal adhesion assembly (GO:0048041)5.02273428
8cell-substrate adherens junction assembly (GO:0007045)5.02273428
9endothelium development (GO:0003158)4.99647557
10L-phenylalanine metabolic process (GO:0006558)4.93852761
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.93852761
12heart valve formation (GO:0003188)4.73379673
13cardiac left ventricle morphogenesis (GO:0003214)4.68611408
14low-density lipoprotein particle clearance (GO:0034383)4.64418172
15regulation of extracellular matrix disassembly (GO:0010715)4.56125266
16cardiac right ventricle morphogenesis (GO:0003215)4.53417364
17peptidyl-glutamic acid carboxylation (GO:0017187)4.45737854
18protein carboxylation (GO:0018214)4.45737854
19stem cell development (GO:0048864)4.42921103
20heart trabecula morphogenesis (GO:0061384)4.42737873
21regulation of fibrinolysis (GO:0051917)4.41730848
22adherens junction assembly (GO:0034333)4.38231900
23atrial cardiac muscle cell action potential (GO:0086014)4.38028358
24neural crest cell development (GO:0014032)4.36753564
25negative regulation of fibrinolysis (GO:0051918)4.36391219
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.23255617
27L-phenylalanine catabolic process (GO:0006559)4.23255617
28tonic smooth muscle contraction (GO:0014820)4.17434677
29basement membrane organization (GO:0071711)4.13528598
30heart trabecula formation (GO:0060347)4.04274081
31regulation of plasminogen activation (GO:0010755)4.04138253
32negative regulation of fatty acid transport (GO:2000192)4.03431892
33trabecula morphogenesis (GO:0061383)3.94885461
34negative regulation of striated muscle cell apoptotic process (GO:0010664)3.90290563
35atrial septum morphogenesis (GO:0060413)3.85967646
36aorta morphogenesis (GO:0035909)3.84950440
37ventricular septum morphogenesis (GO:0060412)3.84030003
38cochlea development (GO:0090102)3.80037694
39negative regulation of cell size (GO:0045792)3.78373986
40regulation of vasculogenesis (GO:2001212)3.73701252
41regulation of heart morphogenesis (GO:2000826)3.69249363
42embryonic heart tube development (GO:0035050)3.69243983
43regulation of fatty acid beta-oxidation (GO:0031998)3.69041864
44positive regulation of lipoprotein lipase activity (GO:0051006)3.63901389
45positive regulation of triglyceride lipase activity (GO:0061365)3.63901389
46cardiac ventricle morphogenesis (GO:0003208)3.61597847
47cell adhesion mediated by integrin (GO:0033627)3.58525963
48regulation of secondary heart field cardioblast proliferation (GO:0003266)3.57880078
49regulation of cardioblast proliferation (GO:0003264)3.57880078
50artery smooth muscle contraction (GO:0014824)3.55055727
51cardiac muscle cell proliferation (GO:0060038)3.53247946
52positive regulation of extracellular matrix organization (GO:1903055)3.50045861
53vascular endothelial growth factor signaling pathway (GO:0038084)3.48490517
54regulation of cholesterol homeostasis (GO:2000188)3.47469966
55lymphangiogenesis (GO:0001946)3.46983726
56smooth muscle cell differentiation (GO:0051145)3.44876503
57vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.42675843
58positive regulation of protein dephosphorylation (GO:0035307)3.40688807
59cardiac chamber morphogenesis (GO:0003206)3.39234127
60gap junction assembly (GO:0016264)3.38954537
61regulation of extracellular matrix organization (GO:1903053)3.38329397
62outflow tract morphogenesis (GO:0003151)3.35609738
63endothelial cell differentiation (GO:0045446)3.33914636
64heart valve morphogenesis (GO:0003179)3.33540751
65cell-substrate junction assembly (GO:0007044)3.30703943
66negative regulation of stress fiber assembly (GO:0051497)3.29333019
67urea metabolic process (GO:0019627)3.28425387
68urea cycle (GO:0000050)3.27953114
69ventricular cardiac muscle cell development (GO:0055015)3.27622319
70negative regulation of smooth muscle cell differentiation (GO:0051151)3.27586064
71regulation of cholesterol biosynthetic process (GO:0045540)3.24537061
72plasma lipoprotein particle clearance (GO:0034381)3.23024315
73endocardial cushion morphogenesis (GO:0003203)3.19552411
74maternal placenta development (GO:0001893)3.18914734
75negative regulation of Rho protein signal transduction (GO:0035024)3.18245936
76regulation of cell proliferation involved in kidney development (GO:1901722)3.18138289
77proline biosynthetic process (GO:0006561)3.17607597
78negative regulation of smooth muscle cell migration (GO:0014912)3.14654795
79regulation of protein activation cascade (GO:2000257)3.14232969
80retina vasculature morphogenesis in camera-type eye (GO:0061299)3.13639735
81proline metabolic process (GO:0006560)3.12061409
82regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.11602541
83germ cell migration (GO:0008354)3.10294890
84protein retention in ER lumen (GO:0006621)3.10178206
85artery morphogenesis (GO:0048844)3.08202932
86cell proliferation involved in kidney development (GO:0072111)3.07345051
87patterning of blood vessels (GO:0001569)3.06730702
88cholesterol efflux (GO:0033344)3.06653327
89cell surface receptor signaling pathway involved in heart development (GO:0061311)3.06081346
90regulation of complement activation (GO:0030449)3.05744896
91cardiac epithelial to mesenchymal transition (GO:0060317)3.04267081
92nitrogen cycle metabolic process (GO:0071941)3.03787788
93transcytosis (GO:0045056)3.03700567
94insulin-like growth factor receptor signaling pathway (GO:0048009)3.00517834
95positive regulation of heart rate (GO:0010460)2.98821933
96vascular smooth muscle contraction (GO:0014829)2.98819686
97negative regulation of catenin import into nucleus (GO:0035414)2.98684977
98collagen fibril organization (GO:0030199)2.97267920
99acylglycerol catabolic process (GO:0046464)2.97082326
100neutral lipid catabolic process (GO:0046461)2.97082326
101regulation of cholesterol esterification (GO:0010872)2.96945530
102auditory receptor cell differentiation (GO:0042491)2.96263123
103NADH metabolic process (GO:0006734)2.95626288
104fibrinolysis (GO:0042730)2.95131102
105regulation of cardiac muscle cell apoptotic process (GO:0010665)2.94619072
106muscle cell proliferation (GO:0033002)2.93974959
107cardiac muscle adaptation (GO:0014887)2.93374089
108cardiac muscle hypertrophy in response to stress (GO:0014898)2.93374089
109muscle hypertrophy in response to stress (GO:0003299)2.93374089
110oligosaccharide catabolic process (GO:0009313)2.93176883
111negative regulation of vascular permeability (GO:0043116)2.92673174
112cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.91382405
113triglyceride catabolic process (GO:0019433)2.89928432
114regulation of apoptotic process involved in morphogenesis (GO:1902337)2.88541536
115Golgi transport vesicle coating (GO:0048200)2.88404457
116COPI coating of Golgi vesicle (GO:0048205)2.88404457
117striated muscle cell proliferation (GO:0014855)2.88361454
118maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.88089901
119positive regulation of astrocyte differentiation (GO:0048711)2.87253502
120regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.86278880
121regulation of bile acid biosynthetic process (GO:0070857)2.86108864
122regulation of glucose import in response to insulin stimulus (GO:2001273)2.86053980
123positive regulation of muscle hypertrophy (GO:0014742)2.85777264
124positive regulation of cardiac muscle hypertrophy (GO:0010613)2.85777264
125biotin metabolic process (GO:0006768)2.84237977
126glomerular basement membrane development (GO:0032836)2.83998096
127glucose 6-phosphate metabolic process (GO:0051156)2.83988409
128trabecula formation (GO:0060343)2.83546122
129positive regulation of lipid catabolic process (GO:0050996)2.83128925
130negative regulation of fatty acid biosynthetic process (GO:0045717)2.82503870
131negative regulation of glial cell proliferation (GO:0060253)2.81949556
132regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.80471291
133amino-acid betaine metabolic process (GO:0006577)2.79285229
134labyrinthine layer blood vessel development (GO:0060716)2.78042178
135negative regulation of muscle cell apoptotic process (GO:0010656)2.77840092
136atrioventricular valve morphogenesis (GO:0003181)2.77681731
137embryonic process involved in female pregnancy (GO:0060136)2.77333140
138protein maturation by protein folding (GO:0022417)2.77288854
139regulation of endothelial cell chemotaxis (GO:2001026)2.74306683
140embryonic foregut morphogenesis (GO:0048617)2.74170387
141negative regulation of lipase activity (GO:0060192)2.72769201
142acylglycerol homeostasis (GO:0055090)2.71876033
143triglyceride homeostasis (GO:0070328)2.71876033
144plasma lipoprotein particle remodeling (GO:0034369)2.71117802
145protein-lipid complex remodeling (GO:0034368)2.71117802
146macromolecular complex remodeling (GO:0034367)2.71117802
147regulation of cholesterol storage (GO:0010885)2.70876472
148cell proliferation involved in metanephros development (GO:0072203)2.70369090
149regulation of striated muscle cell apoptotic process (GO:0010662)2.69968162
150carnitine metabolic process (GO:0009437)2.69480296
151glomerular filtration (GO:0003094)2.68498410
152kidney mesenchyme development (GO:0072074)2.67968039
153protein localization to endosome (GO:0036010)2.67085065
154positive regulation of fatty acid beta-oxidation (GO:0032000)2.66697281
155negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.66605412
156metanephric mesenchyme development (GO:0072075)2.66215798
157positive regulation of smooth muscle cell migration (GO:0014911)2.66167655
158high-density lipoprotein particle remodeling (GO:0034375)2.65966986
159branching involved in mammary gland duct morphogenesis (GO:0060444)2.65893725
160potassium ion import (GO:0010107)2.63023583
161cellular zinc ion homeostasis (GO:0006882)2.61816874
162positive regulation of cellular amine metabolic process (GO:0033240)2.61495115
163intestinal cholesterol absorption (GO:0030299)2.60334042
164cGMP-mediated signaling (GO:0019934)2.60214431
165negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.59941151
166negative regulation of cholesterol transport (GO:0032375)2.59519787
167negative regulation of sterol transport (GO:0032372)2.59519787
168renal filtration (GO:0097205)2.59046551
169regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.58771601
170positive regulation of Cdc42 GTPase activity (GO:0043089)2.58648745
171dicarboxylic acid biosynthetic process (GO:0043650)2.56994932
172negative regulation of lipid transport (GO:0032369)2.56990041
173regulation of cholesterol metabolic process (GO:0090181)2.56655486
174hypotonic response (GO:0006971)2.56612935
175blood vessel morphogenesis (GO:0048514)2.56342546
176exocrine pancreas development (GO:0031017)2.56031192
177vasculogenesis (GO:0001570)2.55694065
178diacylglycerol metabolic process (GO:0046339)2.54565827
179ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.53122089
180GDP-mannose metabolic process (GO:0019673)2.52780779
181positive regulation of fatty acid biosynthetic process (GO:0045723)2.52728956
182embryonic viscerocranium morphogenesis (GO:0048703)2.50979190
183cardiac muscle hypertrophy (GO:0003300)2.50924329
184regulation of fatty acid oxidation (GO:0046320)2.50792798
185endothelial cell chemotaxis (GO:0035767)2.49846967
186triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.49639561
187positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.48455745
188reverse cholesterol transport (GO:0043691)2.48267038
189cardiac ventricle formation (GO:0003211)2.48128607
190chondrocyte proliferation (GO:0035988)2.47726158
191phagocytosis, recognition (GO:0006910)2.47544086
192secondary heart field specification (GO:0003139)2.47355251
193heart field specification (GO:0003128)2.47355251
194blood coagulation, intrinsic pathway (GO:0007597)2.46134476
195muscle cell migration (GO:0014812)2.45573624
196endodermal cell differentiation (GO:0035987)2.45007429

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.33540423
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.78632632
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.70216763
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.68246357
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.45342377
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.81416211
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.65105728
8LXR_22292898_ChIP-Seq_THP-1_Human2.64032942
9ZNF263_19887448_ChIP-Seq_K562_Human2.61724185
10RACK7_27058665_Chip-Seq_MCF-7_Human2.55450232
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.52714394
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.40255180
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34684431
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28421120
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.28095540
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.24826470
17MYC_22102868_ChIP-Seq_BL_Human2.24054540
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.20003101
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19338493
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.16409056
21WT1_19549856_ChIP-ChIP_CCG9911_Human2.12118050
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.10125978
23CDX2_19796622_ChIP-Seq_MESCs_Mouse2.06489951
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95826872
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92634595
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.90394387
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.90394387
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.89060337
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.88750176
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88222697
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87627770
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.87525503
33LXR_22158963_ChIP-Seq_LIVER_Mouse1.87524289
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84808039
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84665578
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84136680
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.81053634
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.80475657
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.80096516
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.79965937
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.77626313
42CLOCK_20551151_ChIP-Seq_293T_Human1.76126153
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.75061745
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.74869839
45ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.74319603
46VDR_21846776_ChIP-Seq_THP-1_Human1.71190343
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67967363
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66530996
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.61851345
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.61337796
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.59788035
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59702291
53SOX2_20726797_ChIP-Seq_SW620_Human1.59554467
54SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57921120
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56235664
56TCF7_22412390_ChIP-Seq_EML_Mouse1.53096222
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51904843
58CJUN_26792858_Chip-Seq_BT549_Human1.51332452
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51069524
60TP53_16413492_ChIP-PET_HCT116_Human1.50977913
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.50860973
62EZH2_22144423_ChIP-Seq_EOC_Human1.47375817
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43144401
64FOXA2_19822575_ChIP-Seq_HepG2_Human1.42642767
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.42401225
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.39891451
67DROSHA_22980978_ChIP-Seq_HELA_Human1.39569362
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39461211
69ISL1_27105846_Chip-Seq_CPCs_Mouse1.38473127
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37597781
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37130593
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37130593
73ATF3_27146783_Chip-Seq_COLON_Human1.36466675
74SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.36086401
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34489891
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33198256
77AHR_22903824_ChIP-Seq_MCF-7_Human1.33164917
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.32057198
79TBX20_22328084_ChIP-Seq_HEART_Mouse1.31770403
80TBX20_22080862_ChIP-Seq_HEART_Mouse1.31770403
81CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31158919
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.30103375
83P68_20966046_ChIP-Seq_HELA_Human1.30036181
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.28809804
85ESR1_20079471_ChIP-ChIP_T-47D_Human1.28036375
86FOXO3_23340844_ChIP-Seq_DLD1_Human1.26123974
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.24321789
88SMC4_20622854_ChIP-Seq_HELA_Human1.23893232
89KDM2B_26808549_Chip-Seq_DND41_Human1.22730928
90SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.22479568
91SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21931157
92EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21226597
93PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20870009
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20711874
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19338997
96TP53_18474530_ChIP-ChIP_U2OS_Human1.18497349
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17647422
98EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17496013
99TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.17440851
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17311035
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17040870
102TP53_22127205_ChIP-Seq_IMR90_Human1.16854899
103RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16705314
104ERG_21242973_ChIP-ChIP_JURKAT_Human1.13727138
105WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13523141
106CDX2_20551321_ChIP-Seq_CACO-2_Human1.12945055
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12449488
108E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12444423
109SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11774923
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11388622
111SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11118240
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10750921
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10508733
114UBF1/2_26484160_Chip-Seq_HMECs_Human1.10114979
115NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09816398
116KDM2B_26808549_Chip-Seq_K562_Human1.09368164
117PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07713205
118DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07200625
119TP53_20018659_ChIP-ChIP_R1E_Mouse1.07052206
120RING1B_27294783_Chip-Seq_NPCs_Mouse1.06880940
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06786007
122CBX2_27304074_Chip-Seq_ESCs_Mouse1.06689813
123KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06453094
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04443682
125GATA1_22025678_ChIP-Seq_K562_Human1.04357752
126SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02498473
127SA1_27219007_Chip-Seq_ERYTHROID_Human1.01825453
128RARB_24833708_ChIP-Seq_LIVER_Mouse1.01464798
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01143471
130TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00821799
131P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99284866
132CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99047157
133RING1B_27294783_Chip-Seq_ESCs_Mouse0.99035587
134KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98494470
135CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97978470
136GATA3_24758297_ChIP-Seq_MCF-7_Human0.97560343
137P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97398054
138BCAT_22108803_ChIP-Seq_LS180_Human0.96707144
139CREB1_26743006_Chip-Seq_LNCaP_Human0.96107905
140KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95945042
141ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95243876
142BRD4_25478319_ChIP-Seq_HGPS_Human0.94796119
143JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.94752112
144PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94714636
145HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93684846
146RUNX1_27514584_Chip-Seq_MCF-7_Human0.93429598
147PIAS1_25552417_ChIP-Seq_VCAP_Human0.93100718
148NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93096141
149RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92576394
150CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.91796541
151CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90883612
152HNF4A_19822575_ChIP-Seq_HepG2_Human0.90447289
153BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90273696
154RARA_24833708_ChIP-Seq_LIVER_Mouse0.90241027
155SMC1_22415368_ChIP-Seq_MEFs_Mouse0.89638014
156SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89552629
157STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88905087
158CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88272387
159AR_19668381_ChIP-Seq_PC3_Human0.87801749
160STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87157146
161GATA4_25053715_ChIP-Seq_YYC3_Human0.86473133
162KDM2B_26808549_Chip-Seq_JURKAT_Human0.86108635
163BCOR_27268052_Chip-Seq_Bcells_Human0.85956467
164OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84988704
165SMAD4_21741376_ChIP-Seq_HESCs_Human0.84930080
166OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84764183
167SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.84681400
168SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.84681400
169FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83792808
170BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83415761
171MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.81247502

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009384_cardiac_valve_regurgitation5.19132985
2MP0002139_abnormal_hepatobiliary_system5.14261147
3MP0005623_abnormal_meninges_morphology4.41321219
4MP0004272_abnormal_basement_membrane3.89108555
5MP0003705_abnormal_hypodermis_morpholog3.75711473
6MP0005084_abnormal_gallbladder_morpholo3.53352913
7MP0005360_urolithiasis3.37900361
8MP0002009_preneoplasia3.34196568
9MP0009840_abnormal_foam_cell3.03692643
10MP0005670_abnormal_white_adipose2.95002410
11MP0008004_abnormal_stomach_pH2.90438104
12MP0009379_abnormal_foot_pigmentation2.89999860
13MP0003191_abnormal_cellular_cholesterol2.67676503
14MP0005058_abnormal_lysosome_morphology2.57193742
15MP0001879_abnormal_lymphatic_vessel2.45551432
16MP0008438_abnormal_cutaneous_collagen2.42303085
17MP0005451_abnormal_body_composition2.42092901
18MP0005365_abnormal_bile_salt2.41292833
19MP0005083_abnormal_biliary_tract2.38075156
20MP0003279_aneurysm2.32519459
21MP0005167_abnormal_blood-brain_barrier2.31802178
22MP0005076_abnormal_cell_differentiation2.17057812
23MP0005257_abnormal_intraocular_pressure2.16915058
24MP0010329_abnormal_lipoprotein_level2.12053255
25MP0002127_abnormal_cardiovascular_syste2.08197680
26MP0001661_extended_life_span2.01590996
27MP0008875_abnormal_xenobiotic_pharmacok2.01583731
28MP0005085_abnormal_gallbladder_physiolo2.01321686
29MP0000013_abnormal_adipose_tissue1.99528085
30MP0010368_abnormal_lymphatic_system1.98254174
31MP0003283_abnormal_digestive_organ1.92433057
32MP0006138_congestive_heart_failure1.74916076
33MP0001664_abnormal_digestion1.74654317
34MP0005375_adipose_tissue_phenotype1.71242117
35MP0003300_gastrointestinal_ulcer1.70966855
36MP0005666_abnormal_adipose_tissue1.69495434
37MP0002928_abnormal_bile_duct1.66324577
38MP0003252_abnormal_bile_duct1.64956379
39MP0010030_abnormal_orbit_morphology1.64416508
40MP0003868_abnormal_feces_composition1.64029117
41MP0001346_abnormal_lacrimal_gland1.62350967
42MP0002896_abnormal_bone_mineralization1.62170549
43MP0003123_paternal_imprinting1.62167598
44MP0002282_abnormal_trachea_morphology1.59546321
45MP0000767_abnormal_smooth_muscle1.56035971
46MP0004484_altered_response_of1.49325979
47MP0005503_abnormal_tendon_morphology1.49164464
48MP0003091_abnormal_cell_migration1.48690620
49MP0005332_abnormal_amino_acid1.48148051
50MP0006054_spinal_hemorrhage1.47910962
51MP0002972_abnormal_cardiac_muscle1.45200585
52MP0001666_abnormal_nutrient_absorption1.44332724
53MP0004215_abnormal_myocardial_fiber1.43286712
54MP0002138_abnormal_hepatobiliary_system1.43245764
55MP0005330_cardiomyopathy1.41257677
56MP0005620_abnormal_muscle_contractility1.40870738
57MP0003195_calcinosis1.40406022
58MP0000609_abnormal_liver_physiology1.39147066
59MP0003950_abnormal_plasma_membrane1.39079915
60MP0000462_abnormal_digestive_system1.37254381
61MP0004085_abnormal_heartbeat1.35594650
62MP0003787_abnormal_imprinting1.35313387
63MP0003172_abnormal_lysosome_physiology1.33074386
64MP0005165_increased_susceptibility_to1.32817421
65MP0002118_abnormal_lipid_homeostasis1.32559141
66MP0005595_abnormal_vascular_smooth1.29596852
67MP0002295_abnormal_pulmonary_circulatio1.28093775
68MP0009780_abnormal_chondrocyte_physiolo1.24427872
69MP0000516_abnormal_urinary_system1.22660351
70MP0005367_renal/urinary_system_phenotyp1.22660351
71MP0001299_abnormal_eye_distance/1.22010648
72MP0010630_abnormal_cardiac_muscle1.21201941
73MP0009115_abnormal_fat_cell1.20965226
74MP0002970_abnormal_white_adipose1.20056810
75MP0000749_muscle_degeneration1.20047737
76MP0000751_myopathy1.18892572
77MP0010386_abnormal_urinary_bladder1.14742490
78MP0005584_abnormal_enzyme/coenzyme_acti1.13506762
79MP0000750_abnormal_muscle_regeneration1.10055753
80MP0004185_abnormal_adipocyte_glucose1.09089533
81MP0003137_abnormal_impulse_conducting1.08400154
82MP0005164_abnormal_response_to1.07698611
83MP0001958_emphysema1.07569241
84MP0000163_abnormal_cartilage_morphology1.06708127
85MP0002166_altered_tumor_susceptibility1.06583825
86MP0000003_abnormal_adipose_tissue1.06320751
87MP0002108_abnormal_muscle_morphology1.05772946
88MP0009643_abnormal_urine_homeostasis1.05380987
89MP0004233_abnormal_muscle_weight1.05094901
90MP0002971_abnormal_brown_adipose1.04701951
91MP0010234_abnormal_vibrissa_follicle1.03283635
92MP0005409_darkened_coat_color1.03245631
93MP0002925_abnormal_cardiovascular_devel1.01787511
94MP0005508_abnormal_skeleton_morphology1.00154925
95MP0005319_abnormal_enzyme/_coenzyme0.99720989
96MP0002751_abnormal_autonomic_nervous0.98696564
97MP0003828_pulmonary_edema0.97581203
98MP0000762_abnormal_tongue_morphology0.97279882
99MP0008569_lethality_at_weaning0.97102289
100MP0004084_abnormal_cardiac_muscle0.96691865
101MP0000537_abnormal_urethra_morphology0.95497917
102MP0005220_abnormal_exocrine_pancreas0.95296878
103MP0003879_abnormal_hair_cell0.95000730
104MP0002269_muscular_atrophy0.94625815
105MP0009250_abnormal_appendicular_skeleto0.94425983
106MP0003329_amyloid_beta_deposits0.94225819
107MP0004087_abnormal_muscle_fiber0.93704173
108MP0002909_abnormal_adrenal_gland0.93372171
109MP0000747_muscle_weakness0.93241340
110MP0005408_hypopigmentation0.90903570
111MP0002837_dystrophic_cardiac_calcinosis0.90484218
112MP0004858_abnormal_nervous_system0.88832964
113MP0001544_abnormal_cardiovascular_syste0.88615045
114MP0005385_cardiovascular_system_phenoty0.88615045
115MP0002128_abnormal_blood_circulation0.87889239
116MP0002876_abnormal_thyroid_physiology0.87888995
117MP0003075_altered_response_to0.87820981
118MP0000049_abnormal_middle_ear0.87607168
119MP0003959_abnormal_lean_body0.86756761
120MP0000733_abnormal_muscle_development0.86568505
121MP0004883_abnormal_blood_vessel0.85726139
122MP0002249_abnormal_larynx_morphology0.85309280
123MP0005501_abnormal_skin_physiology0.84960335
124MP0004264_abnormal_extraembryonic_tissu0.84401853
125MP0005275_abnormal_skin_tensile0.84330126
126MP0000534_abnormal_ureter_morphology0.83578448
127MP0003045_fibrosis0.82977355
128MP0001614_abnormal_blood_vessel0.81362650
129MP0002796_impaired_skin_barrier0.81214514
130MP0004134_abnormal_chest_morphology0.80069034
131MP0002078_abnormal_glucose_homeostasis0.79923869
132MP0003566_abnormal_cell_adhesion0.79438033
133MP0000598_abnormal_liver_morphology0.79288938
134MP0002060_abnormal_skin_morphology0.78846106
135MP0009697_abnormal_copulation0.78646144
136MP0001270_distended_abdomen0.77330233
137MP0002877_abnormal_melanocyte_morpholog0.76284575
138MP0001873_stomach_inflammation0.76183719
139MP0000230_abnormal_systemic_arterial0.75260152
140MP0003942_abnormal_urinary_system0.74852698
141MP0005381_digestive/alimentary_phenotyp0.74298597
142MP0002938_white_spotting0.74092255
143MP0001849_ear_inflammation0.72773743
144MP0009278_abnormal_bone_marrow0.72392986
145MP0001915_intracranial_hemorrhage0.72186461
146MP0002089_abnormal_postnatal_growth/wei0.71913009
147MP0000249_abnormal_blood_vessel0.71824152
148MP0005452_abnormal_adipose_tissue0.71767905
149MP0001944_abnormal_pancreas_morphology0.71502353
150MP0003935_abnormal_craniofacial_develop0.71327392
151MP0000685_abnormal_immune_system0.70823558
152MP0005023_abnormal_wound_healing0.69366201
153MP0003638_abnormal_response/metabolism_0.66771191
154MP0005423_abnormal_somatic_nervous0.59654128
155MP0004130_abnormal_muscle_cell0.58980464
156MP0010678_abnormal_skin_adnexa0.57619161

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.03215743
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.14428883
3J-shaped sella turcica (HP:0002680)4.05174660
4Aortic aneurysm (HP:0004942)3.99105851
5Microglossia (HP:0000171)3.95226338
6Prolonged partial thromboplastin time (HP:0003645)3.92446211
7Short hallux (HP:0010109)3.86882590
8Broad metatarsal (HP:0001783)3.84119265
9Premature rupture of membranes (HP:0001788)3.68216119
10Aortic dissection (HP:0002647)3.65634898
11Aplasia/Hypoplasia of the hallux (HP:0008362)3.62831013
12Hypoplastic ischia (HP:0003175)3.59977546
13Hemorrhage of the eye (HP:0011885)3.56853665
14Joint hemorrhage (HP:0005261)3.48727387
15Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.39245351
16Prolonged neonatal jaundice (HP:0006579)3.37031428
17Abnormality of monocarboxylic acid metabolism (HP:0010996)3.33090582
18Spinal rigidity (HP:0003306)3.28273425
19Abnormality of the ischium (HP:0003174)3.24809777
20Ventricular fibrillation (HP:0001663)3.22607751
21Vertebral compression fractures (HP:0002953)3.12888196
22Asymmetry of the thorax (HP:0001555)3.12515857
23Epiphyseal dysplasia (HP:0002656)3.11340693
24Increased connective tissue (HP:0009025)3.09639730
25Glucose intolerance (HP:0000833)3.09133356
26Protrusio acetabuli (HP:0003179)3.01412962
27Hypercholesterolemia (HP:0003124)2.90231119
28Hyperacusis (HP:0010780)2.87406768
29Xanthomatosis (HP:0000991)2.76433945
30Vascular calcification (HP:0004934)2.74247697
31Cerebral aneurysm (HP:0004944)2.73832398
32Ankle contracture (HP:0006466)2.72981988
33Deformed sella turcica (HP:0002681)2.72916176
34Arterial tortuosity (HP:0005116)2.72028770
35Venous insufficiency (HP:0005293)2.70861807
36Mucopolysacchariduria (HP:0008155)2.67322416
37Urinary glycosaminoglycan excretion (HP:0003541)2.67322416
38Abnormality of dentin (HP:0010299)2.65309259
39Congenital, generalized hypertrichosis (HP:0004540)2.64558331
40Metaphyseal dysplasia (HP:0100255)2.63938618
41Cardiovascular calcification (HP:0011915)2.63069705
42Complement deficiency (HP:0004431)2.62036923
43Vascular tortuosity (HP:0004948)2.60265383
44Hypercortisolism (HP:0001578)2.59784155
45Cervical subluxation (HP:0003308)2.57218450
46Abnormality of complement system (HP:0005339)2.55516591
47Abnormality of polysaccharide metabolism (HP:0011012)2.52949531
48Abnormality of glycosaminoglycan metabolism (HP:0004371)2.52949531
49Abnormality of mucopolysaccharide metabolism (HP:0011020)2.52949531
50Infantile muscular hypotonia (HP:0008947)2.52258512
51Abnormal hemoglobin (HP:0011902)2.50116002
52Mitral stenosis (HP:0001718)2.50066027
53Venous abnormality (HP:0002624)2.47979114
54Shallow orbits (HP:0000586)2.47644778
55Abnormality of the sella turcica (HP:0002679)2.44585557
56Hypertriglyceridemia (HP:0002155)2.43348461
57Hydroureter (HP:0000072)2.42981243
58Prolonged QT interval (HP:0001657)2.40960736
59Type 1 muscle fiber predominance (HP:0003803)2.39987727
60Abnormality of the Achilles tendon (HP:0005109)2.39899810
61Fragile skin (HP:0001030)2.38950923
62Absent toe (HP:0010760)2.37925159
63Neonatal short-limb short stature (HP:0008921)2.37127545
64Spondylolisthesis (HP:0003302)2.35677154
65Distal lower limb amyotrophy (HP:0008944)2.34726820
66Acanthosis nigricans (HP:0000956)2.34606674
67Nuclear cataract (HP:0100018)2.34312410
68Wormian bones (HP:0002645)2.32569961
69Cerebral hemorrhage (HP:0001342)2.31903289
70Adactyly (HP:0009776)2.31425781
71Hypoalphalipoproteinemia (HP:0003233)2.30516954
72Bone cyst (HP:0012062)2.27175267
73Myocardial infarction (HP:0001658)2.27064112
74Back pain (HP:0003418)2.24973862
75Mildly elevated creatine phosphokinase (HP:0008180)2.24434740
76Vertebral arch anomaly (HP:0008438)2.21977955
77Abnormality of the calf musculature (HP:0001430)2.21595771
78Micronodular cirrhosis (HP:0001413)2.21515290
79Hypoventilation (HP:0002791)2.17592704
80Dysostosis multiplex (HP:0000943)2.17407406
81Striae distensae (HP:0001065)2.16597868
82Achilles tendon contracture (HP:0001771)2.16152141
83Scapular winging (HP:0003691)2.13998920
84Abnormal tarsal ossification (HP:0008369)2.12974557
85Increased variability in muscle fiber diameter (HP:0003557)2.12107516
86Agitation (HP:0000713)2.11042172
87Pheochromocytoma (HP:0002666)2.10871243
88Hypobetalipoproteinemia (HP:0003563)2.10459685
89Pulmonary artery stenosis (HP:0004415)2.09960033
90Buphthalmos (HP:0000557)2.09693527
91Hypoglycemic coma (HP:0001325)2.09578263
92Esophageal varix (HP:0002040)2.09188523
93Spinal cord compression (HP:0002176)2.07497741
94Renovascular hypertension (HP:0100817)2.06998681
95Hypoplasia of the iris (HP:0007676)2.06228463
96Distal lower limb muscle weakness (HP:0009053)2.06093592
97Abnormal glucose tolerance (HP:0001952)2.05744000
98Abnormality of the common coagulation pathway (HP:0010990)2.05725985
99Insomnia (HP:0100785)2.05310488
100Tetraparesis (HP:0002273)2.05168732
101Menorrhagia (HP:0000132)2.04797710
102Lymphangioma (HP:0100764)2.04004804
103Abnormality of lateral ventricle (HP:0030047)2.02938110
104Axonal loss (HP:0003447)2.02612008
105Abnormality of carpal bone ossification (HP:0006257)2.01928421
106Hypolipoproteinemia (HP:0010981)2.00347367
107Cardiomegaly (HP:0001640)1.99138623
108Limb-girdle muscle atrophy (HP:0003797)1.97763925
109Mesangial abnormality (HP:0001966)1.94965136
110Long toe (HP:0010511)1.94120854
111Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.93778889
112Septate vagina (HP:0001153)1.93679089
113Abnormality of calcium-phosphate metabolism (HP:0100530)1.91248421
114Abnormality of cells of the erythroid lineage (HP:0012130)1.91000385
115Hyperlipoproteinemia (HP:0010980)1.90695252
116Stroke (HP:0001297)1.90416023
117Soft skin (HP:0000977)1.90205246
118Cupped ribs (HP:0000887)1.89962138
119Subcapsular cataract (HP:0000523)1.89935490
120Insulin resistance (HP:0000855)1.89555504
121Glomerulonephritis (HP:0000099)1.88708524
122Hypoplastic nipples (HP:0002557)1.88498705
123Abnormal ossification of hand bones (HP:0005921)1.88478159
124Retinal dysplasia (HP:0007973)1.88410437
125Short nail (HP:0001799)1.87999466
126Prominent supraorbital ridges (HP:0000336)1.87406032
127Advanced eruption of teeth (HP:0006288)1.85066525
128Sparse lateral eyebrow (HP:0005338)1.84830496
129Abnormal foot bone ossification (HP:0010675)1.84625711
130Severe short stature (HP:0003510)1.84486917
131Entropion (HP:0000621)1.83977648
132Hip contracture (HP:0003273)1.83678835
133Biconcave vertebral bodies (HP:0004586)1.83325810
134Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.83111875
135Absent hand (HP:0004050)1.81991768
136Hypercalcemia (HP:0003072)1.80620473
137Congenital sensorineural hearing impairment (HP:0008527)1.79340154
138Knee flexion contracture (HP:0006380)1.78511727
139Difficulty climbing stairs (HP:0003551)1.78461217
140Renal duplication (HP:0000075)1.78445205
141Lower limb amyotrophy (HP:0007210)1.78431104
142Abnormal vertebral ossification (HP:0100569)1.78307642
143Atrial fibrillation (HP:0005110)1.78132091
144Distal upper limb amyotrophy (HP:0007149)1.77977109
145Upper limb amyotrophy (HP:0009129)1.77977109
146Overriding aorta (HP:0002623)1.77469173
147Abnormality of the intrinsic pathway (HP:0010989)1.76987701
148Aneurysm (HP:0002617)1.76625700
149Resting tremor (HP:0002322)1.75979480
150Ventricular tachycardia (HP:0004756)1.75416966
151Polygenic inheritance (HP:0010982)1.74614882
152Systemic lupus erythematosus (HP:0002725)1.74236637
153Glossoptosis (HP:0000162)1.74118404
154Testicular atrophy (HP:0000029)1.74093829
155Menstrual irregularities (HP:0000858)1.73861279
156Growth hormone excess (HP:0000845)1.73672111
157Hepatocellular carcinoma (HP:0001402)1.72882573
158Thin bony cortex (HP:0002753)1.72800473
159Abnormal hand bone ossification (HP:0010660)1.72192048
160Focal segmental glomerulosclerosis (HP:0000097)1.71996815
161Flat acetabular roof (HP:0003180)1.71915753
162Atrophic scars (HP:0001075)1.71736625
163Abnormality of skeletal muscle fiber size (HP:0012084)1.71613090
164Late onset (HP:0003584)1.70996749
165Chondrocalcinosis (HP:0000934)1.70269618
166Platyspondyly (HP:0000926)1.70148490
167Ovoid vertebral bodies (HP:0003300)1.70131685
168Mesomelia (HP:0003027)1.69348932
169Ectopia lentis (HP:0001083)1.68857862
170Hepatoblastoma (HP:0002884)1.67632949
171Bicuspid aortic valve (HP:0001647)1.67528247
172Hemangiomatosis (HP:0007461)1.67500233
173Conjugated hyperbilirubinemia (HP:0002908)1.67168797
174Abnormality of the anterior chamber (HP:0000593)1.66509602
175Macroorchidism (HP:0000053)1.66492003
176Bladder diverticulum (HP:0000015)1.66345370
177Supraventricular arrhythmia (HP:0005115)1.65346270
178Abnormality of Sharpey fibers (HP:0100685)1.65228639
179Muscle stiffness (HP:0003552)1.65152479
180Pigmentary retinal degeneration (HP:0001146)1.65003178
181Short distal phalanx of finger (HP:0009882)1.64736137
182Down-sloping shoulders (HP:0200021)1.64434071
183Emphysema (HP:0002097)1.62160095
184Abnormality of glutamine family amino acid metabolism (HP:0010902)1.60762425
185Abdominal distention (HP:0003270)1.60075739
186Natal tooth (HP:0000695)1.59955710

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK5.00096887
2MAPK154.31102952
3NUAK13.79909427
4FRK3.34179654
5MST43.30699795
6TAF13.03658755
7RIPK13.00157466
8SMG12.65437631
9ICK2.63624214
10PAK22.56905236
11PDGFRA2.33564771
12WNK32.23798669
13LMTK22.22860556
14EPHA22.16838619
15PIM22.12896996
16FGFR42.10098696
17MAPKAPK32.08180606
18DDR22.01303092
19PIK3CG2.00793709
20TTN1.99943229
21DMPK1.99732309
22PRPF4B1.95743322
23ARAF1.92436474
24STK391.88988343
25PAK31.86936748
26MAP3K91.85091511
27IRAK31.83451681
28ZAK1.81753998
29PRKG21.78361260
30WNK41.71720283
31PRKD31.67653444
32TIE11.66786680
33PTK2B1.62496064
34PTK21.55819451
35EPHB21.53813335
36RPS6KB21.53812742
37SCYL21.51048172
38ROCK11.43212802
39KSR21.43024717
40MET1.36319367
41CDC42BPA1.34294910
42NTRK11.25857279
43MAP3K131.24159879
44FER1.23750338
45TESK11.23203100
46MAP2K11.21310845
47MAP2K21.19042756
48CDK121.18537909
49WNK11.17793459
50DAPK31.16874501
51PDGFRB1.16582009
52TRIB31.13457469
53TAOK11.12063761
54PRKD21.09920520
55TESK21.09757593
56BCR1.04390184
57MAP3K101.03304334
58PDPK11.03207351
59MAPK111.00425088
60PRKD10.98218522
61SIK10.92646512
62TBK10.91553430
63TRPM70.91358038
64MAPK120.91079520
65MARK20.89678954
66AKT30.89305231
67ABL20.85908779
68SIK20.85702497
69ROCK20.85661054
70DAPK20.85162903
71ILK0.83924876
72MELK0.83383798
73PKN20.82683015
74MUSK0.82583264
75CDK80.81646622
76UHMK10.80093682
77MAP3K20.77485125
78TAOK20.76412153
79PRKCE0.76079155
80PTK60.75386254
81NTRK20.74565901
82CSF1R0.74150398
83TGFBR20.73021811
84LIMK10.72974262
85ZAP700.69506487
86CHUK0.67138618
87FGFR30.67048100
88LRRK20.66075578
89MAP3K30.62866440
90CDK70.61663587
91RET0.61043594
92INSR0.60806363
93PHKG10.60253097
94PHKG20.60253097
95PRKCI0.59477876
96RPS6KB10.59396494
97MAP3K120.58474221
98LATS10.58378444
99MAPKAPK50.57818079
100GSK3A0.57131623
101RPS6KA20.56582531
102PDK10.56476772
103ERBB20.54217594
104PAK40.54198675
105MAP3K10.53033828
106IRAK40.52872334
107NME20.51394542
108ADRBK10.50994762
109AKT20.49773879
110RAF10.48637507
111CAMK10.48291353
112ERN10.47852418
113OXSR10.47221328
114CAMK2G0.44435417
115DYRK1B0.44014037
116ERBB30.43861477
117PRKCH0.43174224
118BMX0.43052498
119PIK3CA0.42875393
120MAP3K110.42518300
121IGF1R0.41177543
122VRK20.40475462
123SIK30.40221017
124CAMK2A0.40079818
125PAK60.39538336
126CAMK1D0.38798226
127MAPKAPK20.38721207
128FGR0.38698629
129MAPK70.38687445
130FGFR20.38592045
131CDK90.38539829
132CCNB10.38319711
133CDK50.37881898
134ITK0.37556096
135NEK60.37302531
136HIPK20.36230443
137DAPK10.35907513
138PRKAA20.35170036
139CAMK2D0.34068991
140GRK60.33756642
141CDK60.33647376
142MST1R0.33561231
143IRAK20.33074776
144SRC0.32751030
145PRKACB0.32343161
146LATS20.32325033
147AURKA0.31890035
148EEF2K0.30986476
149MOS0.30423937
150BCKDK0.30286709
151MAP2K30.29732145
152CSNK1G10.29720054
153PAK10.29425477
154BRAF0.28755135
155CAMKK10.28213557
156MTOR0.27428615
157PLK20.26380234
158CDK140.26314965
159PRKG10.25914872
160ABL10.25604609
161PRKCZ0.25146584
162NEK90.25131650
163SGK2230.25010617
164MAP3K80.24720587

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046102.90605154
2ECM-receptor interaction_Homo sapiens_hsa045122.64993040
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.59405791
4Other glycan degradation_Homo sapiens_hsa005112.49533350
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.48655224
6Protein digestion and absorption_Homo sapiens_hsa049742.43563681
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.37824858
8Pancreatic secretion_Homo sapiens_hsa049722.37403509
9Phenylalanine metabolism_Homo sapiens_hsa003602.29907865
10Vascular smooth muscle contraction_Homo sapiens_hsa042702.20274186
11Focal adhesion_Homo sapiens_hsa045102.15466387
12Renin secretion_Homo sapiens_hsa049242.13033516
13Sulfur relay system_Homo sapiens_hsa041222.06824386
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.02412201
15Dilated cardiomyopathy_Homo sapiens_hsa054142.02317099
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.00501090
17Gastric acid secretion_Homo sapiens_hsa049711.83243008
18Prion diseases_Homo sapiens_hsa050201.82771555
19Protein export_Homo sapiens_hsa030601.80929800
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.79138445
21ABC transporters_Homo sapiens_hsa020101.76839395
22Arginine biosynthesis_Homo sapiens_hsa002201.73212923
23PPAR signaling pathway_Homo sapiens_hsa033201.69803843
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.68966162
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.68838855
26Vitamin B6 metabolism_Homo sapiens_hsa007501.65499419
27Insulin secretion_Homo sapiens_hsa049111.65472450
28cGMP-PKG signaling pathway_Homo sapiens_hsa040221.60628816
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59834170
30Notch signaling pathway_Homo sapiens_hsa043301.59377467
31Gap junction_Homo sapiens_hsa045401.58515942
32Tight junction_Homo sapiens_hsa045301.57933589
33Histidine metabolism_Homo sapiens_hsa003401.57427628
34Fructose and mannose metabolism_Homo sapiens_hsa000511.57022503
35Adherens junction_Homo sapiens_hsa045201.56347977
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50759786
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.47039595
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.45702777
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.45220520
40Biosynthesis of amino acids_Homo sapiens_hsa012301.38427195
41Sulfur metabolism_Homo sapiens_hsa009201.37728369
42AMPK signaling pathway_Homo sapiens_hsa041521.37395053
43Thyroid hormone synthesis_Homo sapiens_hsa049181.36805349
44Proteoglycans in cancer_Homo sapiens_hsa052051.36759632
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.35450625
46Tyrosine metabolism_Homo sapiens_hsa003501.33434519
47Salivary secretion_Homo sapiens_hsa049701.33129494
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32323732
49Galactose metabolism_Homo sapiens_hsa000521.30830951
50N-Glycan biosynthesis_Homo sapiens_hsa005101.28764991
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25554882
52Circadian entrainment_Homo sapiens_hsa047131.24836244
53Pyruvate metabolism_Homo sapiens_hsa006201.24158923
54Oxytocin signaling pathway_Homo sapiens_hsa049211.22474502
55Fat digestion and absorption_Homo sapiens_hsa049751.22073597
56Pentose phosphate pathway_Homo sapiens_hsa000301.22049815
57Insulin signaling pathway_Homo sapiens_hsa049101.21021428
58Insulin resistance_Homo sapiens_hsa049311.20278469
59Axon guidance_Homo sapiens_hsa043601.19041476
60Vibrio cholerae infection_Homo sapiens_hsa051101.17758143
61cAMP signaling pathway_Homo sapiens_hsa040241.13980320
62Cardiac muscle contraction_Homo sapiens_hsa042601.10498927
63Endometrial cancer_Homo sapiens_hsa052131.09555307
64Oxidative phosphorylation_Homo sapiens_hsa001901.08116383
65Cocaine addiction_Homo sapiens_hsa050301.07497298
66Alzheimers disease_Homo sapiens_hsa050101.07028345
67Carbon metabolism_Homo sapiens_hsa012001.06947575
68Amoebiasis_Homo sapiens_hsa051461.05616176
69Sphingolipid metabolism_Homo sapiens_hsa006001.02892763
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02319554
71Cholinergic synapse_Homo sapiens_hsa047251.02151023
72Adipocytokine signaling pathway_Homo sapiens_hsa049201.01692226
73Melanogenesis_Homo sapiens_hsa049161.00606799
74Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00330486
75* Estrogen signaling pathway_Homo sapiens_hsa049151.00064027
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95746407
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95586370
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95112942
79GnRH signaling pathway_Homo sapiens_hsa049120.94531928
80Rap1 signaling pathway_Homo sapiens_hsa040150.93677515
81Dorso-ventral axis formation_Homo sapiens_hsa043200.92730185
82Ribosome_Homo sapiens_hsa030100.92145781
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91758265
84Calcium signaling pathway_Homo sapiens_hsa040200.91618483
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90268264
86Arginine and proline metabolism_Homo sapiens_hsa003300.89557446
87ErbB signaling pathway_Homo sapiens_hsa040120.89385561
88Acute myeloid leukemia_Homo sapiens_hsa052210.87391209
89Non-small cell lung cancer_Homo sapiens_hsa052230.87130455
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86460983
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.85597501
92Platelet activation_Homo sapiens_hsa046110.85398063
93Glioma_Homo sapiens_hsa052140.84654601
94Fatty acid metabolism_Homo sapiens_hsa012120.84177394
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83908760
96Amphetamine addiction_Homo sapiens_hsa050310.83245444
97Parkinsons disease_Homo sapiens_hsa050120.82056111
98Bile secretion_Homo sapiens_hsa049760.81628354
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81392678
100Long-term depression_Homo sapiens_hsa047300.80896696
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80864758
102Lysosome_Homo sapiens_hsa041420.80056023
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80040222
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80010170
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79039159
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78881032
107Dopaminergic synapse_Homo sapiens_hsa047280.77875764
108B cell receptor signaling pathway_Homo sapiens_hsa046620.77830314
109Serotonergic synapse_Homo sapiens_hsa047260.76028358
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74967457
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73599292
112Fatty acid biosynthesis_Homo sapiens_hsa000610.73351285
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72979178
114Systemic lupus erythematosus_Homo sapiens_hsa053220.72809764
115Ras signaling pathway_Homo sapiens_hsa040140.72525440
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.71782549
117mTOR signaling pathway_Homo sapiens_hsa041500.70688980
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70628728
119Wnt signaling pathway_Homo sapiens_hsa043100.70424435
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70395405
121MicroRNAs in cancer_Homo sapiens_hsa052060.69669572
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69660131
123Thyroid cancer_Homo sapiens_hsa052160.68481239
124TGF-beta signaling pathway_Homo sapiens_hsa043500.67235413
125Renal cell carcinoma_Homo sapiens_hsa052110.66607543
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66052979
127Prostate cancer_Homo sapiens_hsa052150.65999464
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65598529
129Mineral absorption_Homo sapiens_hsa049780.65172431
130Starch and sucrose metabolism_Homo sapiens_hsa005000.65104629
131Melanoma_Homo sapiens_hsa052180.65080779
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64353205
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.64336661
134Hippo signaling pathway_Homo sapiens_hsa043900.63992126
135Glutamatergic synapse_Homo sapiens_hsa047240.63122185
136Ovarian steroidogenesis_Homo sapiens_hsa049130.62888227
137Small cell lung cancer_Homo sapiens_hsa052220.62578824
138Drug metabolism - other enzymes_Homo sapiens_hsa009830.62108277
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61558510
140Chronic myeloid leukemia_Homo sapiens_hsa052200.60772171
141Tryptophan metabolism_Homo sapiens_hsa003800.60467371
142Inositol phosphate metabolism_Homo sapiens_hsa005620.60415049
143Pathways in cancer_Homo sapiens_hsa052000.60233979
144GABAergic synapse_Homo sapiens_hsa047270.59356783
145Chemical carcinogenesis_Homo sapiens_hsa052040.58782576
146beta-Alanine metabolism_Homo sapiens_hsa004100.58078744
147Fatty acid elongation_Homo sapiens_hsa000620.57683016
148Folate biosynthesis_Homo sapiens_hsa007900.56261214
149Basal cell carcinoma_Homo sapiens_hsa052170.55568335
150Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55359593
151Morphine addiction_Homo sapiens_hsa050320.54855741
152Bladder cancer_Homo sapiens_hsa052190.54529529
153Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54191913
154Alcoholism_Homo sapiens_hsa050340.53314997
155Fatty acid degradation_Homo sapiens_hsa000710.53265621
156Lysine degradation_Homo sapiens_hsa003100.52611558
157Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52266637
158Arachidonic acid metabolism_Homo sapiens_hsa005900.50506047
159Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50392834
160Hedgehog signaling pathway_Homo sapiens_hsa043400.49993270
161Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49925631
162Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49034103
163Glucagon signaling pathway_Homo sapiens_hsa049220.47495610
164VEGF signaling pathway_Homo sapiens_hsa043700.47113692
165Huntingtons disease_Homo sapiens_hsa050160.46347463
166Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46283685
167Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45211412
168Retinol metabolism_Homo sapiens_hsa008300.45087329
169HIF-1 signaling pathway_Homo sapiens_hsa040660.43975699

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