GPHA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.33621301
2synapsis (GO:0007129)9.07818170
3interferon-gamma secretion (GO:0072643)7.96848490
4DNA methylation involved in gamete generation (GO:0043046)7.26961862
5male meiosis I (GO:0007141)7.01969080
6chromosome organization involved in meiosis (GO:0070192)6.72290336
7ribosomal small subunit biogenesis (GO:0042274)6.58723398
8hemidesmosome assembly (GO:0031581)6.39470488
9xenobiotic catabolic process (GO:0042178)6.38784691
10male meiosis (GO:0007140)6.35900815
11establishment of skin barrier (GO:0061436)5.99293214
12regulation of cell proliferation involved in kidney development (GO:1901722)5.90842036
13synaptonemal complex assembly (GO:0007130)5.85588128
14meiosis I (GO:0007127)5.77462241
15viral transcription (GO:0019083)5.76265233
16meiotic nuclear division (GO:0007126)5.65134615
17regulation of water loss via skin (GO:0033561)5.64638628
18translational termination (GO:0006415)5.54230423
19positive regulation of meiosis (GO:0045836)5.54177834
20ribosomal large subunit biogenesis (GO:0042273)5.48976257
21female gamete generation (GO:0007292)5.48170106
22mitotic chromosome condensation (GO:0007076)5.44631861
23maturation of SSU-rRNA (GO:0030490)5.33572296
24ribosomal small subunit assembly (GO:0000028)5.31384973
25synaptonemal complex organization (GO:0070193)5.28497699
26DNA synthesis involved in DNA repair (GO:0000731)5.26583443
27meiotic cell cycle (GO:0051321)5.23860670
28positive regulation of meiotic cell cycle (GO:0051446)5.21227698
29gene silencing by RNA (GO:0031047)5.15827596
30negative regulation of meiosis (GO:0045835)5.02813873
31regulation of DNA methylation (GO:0044030)4.99850151
32CENP-A containing nucleosome assembly (GO:0034080)4.97179587
33meiotic cell cycle process (GO:1903046)4.92127192
34chromatin remodeling at centromere (GO:0031055)4.91840603
35negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.81932644
36sister chromatid cohesion (GO:0007062)4.80412063
37oogenesis (GO:0048477)4.74586061
38mitotic sister chromatid cohesion (GO:0007064)4.72025258
39translational elongation (GO:0006414)4.69932920
40keratinocyte proliferation (GO:0043616)4.67567866
41pharyngeal system development (GO:0060037)4.60096074
42ear development (GO:0043583)4.57041737
43response to nitrosative stress (GO:0051409)4.50622455
44negative regulation of kidney development (GO:0090185)4.49559489
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.46424044
46DNA replication checkpoint (GO:0000076)4.46314703
47cardiac right ventricle morphogenesis (GO:0003215)4.45364625
48viral life cycle (GO:0019058)4.44488051
49gonadal mesoderm development (GO:0007506)4.44061195
50regulation of histone H3-K9 methylation (GO:0051570)4.44003255
51regulation of meiosis (GO:0040020)4.43493624
52mitotic metaphase plate congression (GO:0007080)4.42975031
53keratinocyte development (GO:0003334)4.38123959
54cotranslational protein targeting to membrane (GO:0006613)4.35331133
55protein targeting to ER (GO:0045047)4.35238649
56histone exchange (GO:0043486)4.33520441
57uronic acid metabolic process (GO:0006063)4.31227440
58glucuronate metabolic process (GO:0019585)4.31227440
59somatic hypermutation of immunoglobulin genes (GO:0016446)4.28864112
60somatic diversification of immune receptors via somatic mutation (GO:0002566)4.28864112
61purine ribonucleotide transport (GO:0015868)4.26391635
62regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.24481675
63multicellular organismal water homeostasis (GO:0050891)4.24451655
64adenine nucleotide transport (GO:0051503)4.23360965
65cellular protein complex disassembly (GO:0043624)4.19114838
66regulation of meiotic cell cycle (GO:0051445)4.15147492
67establishment of protein localization to endoplasmic reticulum (GO:0072599)4.14610915
68regulation of retinoic acid receptor signaling pathway (GO:0048385)4.12903662
69nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.10875353
70protein localization to endoplasmic reticulum (GO:0070972)4.07395289
71cellular response to interferon-alpha (GO:0035457)4.04589677
72regulation of female gonad development (GO:2000194)4.00819008
73regulation of phospholipase A2 activity (GO:0032429)4.00800727
74cyclooxygenase pathway (GO:0019371)4.00507143
75myoblast migration (GO:0051451)3.98617848
76positive regulation of male gonad development (GO:2000020)3.97601967
77positive regulation of catenin import into nucleus (GO:0035413)3.97523470
78one-carbon compound transport (GO:0019755)3.94626310
79translational initiation (GO:0006413)3.91607188
80regulation of chemokine secretion (GO:0090196)3.91282950
81regulation of cardioblast proliferation (GO:0003264)3.90766526
82regulation of secondary heart field cardioblast proliferation (GO:0003266)3.90766526
83negative regulation of axon extension involved in axon guidance (GO:0048843)3.88405193
84regulation of ruffle assembly (GO:1900027)3.88392913
85DNA replication-independent nucleosome organization (GO:0034724)3.88278319
86DNA replication-independent nucleosome assembly (GO:0006336)3.88278319
87telomere maintenance via semi-conservative replication (GO:0032201)3.87760944
88resolution of meiotic recombination intermediates (GO:0000712)3.85545291
89folic acid transport (GO:0015884)3.80822720
90sphingoid metabolic process (GO:0046519)3.79165205
91prostaglandin metabolic process (GO:0006693)3.79137195
92prostanoid metabolic process (GO:0006692)3.79137195
93oocyte development (GO:0048599)3.78218846
94metaphase plate congression (GO:0051310)3.72035981
95positive regulation of embryonic development (GO:0040019)3.68570580
96prostaglandin biosynthetic process (GO:0001516)3.65566841
97prostanoid biosynthetic process (GO:0046457)3.65566841
98water homeostasis (GO:0030104)3.62614607
99regulation of histone H3-K27 methylation (GO:0061085)3.57279182
100positive regulation of chromosome segregation (GO:0051984)3.57099832
101regulation of mesonephros development (GO:0061217)3.56156156
102protein localization to chromosome, centromeric region (GO:0071459)3.55452486
103positive regulation of actin filament depolymerization (GO:0030836)3.55301612
104purine nucleotide transport (GO:0015865)3.55189292
105regulation of DNA endoreduplication (GO:0032875)3.53781230
106mesonephros development (GO:0001823)3.49772531
107regulation of cardioblast differentiation (GO:0051890)3.45499987
108protein complex disassembly (GO:0043241)3.42638084
109DNA strand elongation involved in DNA replication (GO:0006271)3.40850980
110rRNA modification (GO:0000154)3.40670301
111meiotic chromosome segregation (GO:0045132)3.40375744
112regulation of double-strand break repair via homologous recombination (GO:0010569)3.37066473
113glutathione derivative metabolic process (GO:1901685)3.36184326
114glutathione derivative biosynthetic process (GO:1901687)3.36184326
115regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.36071942
116lateral sprouting from an epithelium (GO:0060601)3.34745096
117DNA strand elongation (GO:0022616)3.32805199
118ribonucleoprotein complex biogenesis (GO:0022613)3.31186568
119positive regulation of T cell migration (GO:2000406)3.29824924
120positive regulation of mitotic sister chromatid separation (GO:1901970)3.29103805
121positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.29103805
122positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.29103805
123protein localization to chromosome (GO:0034502)3.29033958
124protein localization to kinetochore (GO:0034501)3.28547640
125metanephric mesenchyme development (GO:0072075)3.28306876
126positive regulation of gastrulation (GO:2000543)3.27820397
127bundle of His cell to Purkinje myocyte communication (GO:0086069)3.27355319
128gene silencing (GO:0016458)3.27228755
129negative regulation of gene silencing (GO:0060969)3.26876689
130attachment of spindle microtubules to kinetochore (GO:0008608)3.24264158
131regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.23851090
132peptidyl-histidine modification (GO:0018202)3.22445394
133telomere maintenance via recombination (GO:0000722)3.21674971
134negative regulation of meiotic cell cycle (GO:0051447)3.20204356
135macromolecular complex disassembly (GO:0032984)3.19553028
136reciprocal DNA recombination (GO:0035825)3.19315818
137reciprocal meiotic recombination (GO:0007131)3.19315818
138proteasome assembly (GO:0043248)3.18437609
139kinetochore organization (GO:0051383)3.17860995
140establishment of chromosome localization (GO:0051303)3.17560419
141cellular glucuronidation (GO:0052695)3.15248035
142glucosamine-containing compound catabolic process (GO:1901072)3.15206153
143nucleotide-excision repair, DNA gap filling (GO:0006297)3.14712004
144regulation of chromosome segregation (GO:0051983)3.14506379
145DNA methylation (GO:0006306)3.12376708
146DNA alkylation (GO:0006305)3.12376708
147oocyte maturation (GO:0001556)3.10344115
148regulation of glomerulus development (GO:0090192)3.09591862
149generation of neurons (GO:0048699)3.08225625
150atrioventricular valve morphogenesis (GO:0003181)3.04442833
151centriole replication (GO:0007099)3.04394714
152regulation of male gonad development (GO:2000018)3.03654872
153mitotic recombination (GO:0006312)3.02646896
154lung-associated mesenchyme development (GO:0060484)3.02453371
155androgen biosynthetic process (GO:0006702)3.01772524
156intestinal epithelial cell development (GO:0060576)3.01477946
157negative regulation of nuclear division (GO:0051784)3.00565904
158regulation of transforming growth factor beta1 production (GO:0032908)3.00072444
159binding of sperm to zona pellucida (GO:0007339)2.99918235
160positive regulation of mesonephros development (GO:0061213)2.99504174
161positive regulation of respiratory burst (GO:0060267)2.96879476
162DNA replication initiation (GO:0006270)2.95631376
163germ cell development (GO:0007281)2.95471513
164regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.95218859
165protein targeting to membrane (GO:0006612)2.95142347
166amino sugar catabolic process (GO:0046348)2.94539845
167mesenchymal to epithelial transition (GO:0060231)2.93920448
168keratinization (GO:0031424)2.93797195
169positive regulation of chemokine secretion (GO:0090197)2.92856040
170kinetochore assembly (GO:0051382)2.92700917
171positive regulation of cellular amine metabolic process (GO:0033240)2.92194778
172negative regulation of histone methylation (GO:0031061)2.92158958
173glutathione metabolic process (GO:0006749)2.92015249
174negative regulation of DNA-dependent DNA replication (GO:2000104)2.91641706
175telomere maintenance via telomere lengthening (GO:0010833)2.91575167
176regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.91128709
177regulation of mitotic metaphase/anaphase transition (GO:0030071)2.91128709
178regulation of helicase activity (GO:0051095)2.90851711
179regulation of mitotic sister chromatid separation (GO:0010965)2.90504553
180regulation of mitotic sister chromatid segregation (GO:0033047)2.90504553
181regulation of sister chromatid segregation (GO:0033045)2.90504553
182chromosome organization (GO:0051276)2.89917603
183spindle checkpoint (GO:0031577)2.89896610
184negative regulation of chromosome segregation (GO:0051985)2.89860963
185hyperosmotic salinity response (GO:0042538)2.89694529
186histone H2A acetylation (GO:0043968)2.88907384
187protein K6-linked ubiquitination (GO:0085020)2.87918955
188kidney mesenchyme development (GO:0072074)2.87801520
189DNA replication-dependent nucleosome organization (GO:0034723)2.87053962
190DNA replication-dependent nucleosome assembly (GO:0006335)2.87053962
191negative regulation of keratinocyte proliferation (GO:0010839)2.86884507
192negative regulation of mitotic sister chromatid segregation (GO:0033048)2.86635113
193sodium-independent organic anion transport (GO:0043252)2.86395175
194wound healing, spreading of cells (GO:0044319)2.85743546
195epidermis development (GO:0008544)2.83173711
196negative regulation of axon guidance (GO:1902668)2.82981022
197protein heterotetramerization (GO:0051290)2.82963459
198regulation of meiosis I (GO:0060631)11.3511385
199piRNA metabolic process (GO:0034587)11.0209306

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.11397967
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.47560662
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.28011360
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.91319866
5EZH2_22144423_ChIP-Seq_EOC_Human3.60115976
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.48239075
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45837906
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.43426205
9TRIM28_21343339_ChIP-Seq_HEK293_Human3.11644005
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.10615893
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.94892689
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.73420279
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.61702159
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.55529713
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.54834634
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.54834634
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.54834634
18HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.41381213
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.35186292
20SOX9_24532713_ChIP-Seq_HFSC_Mouse2.32657630
21P63_26484246_Chip-Seq_KERATINOCYTES_Human2.29873098
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.18964353
23ESR2_21235772_ChIP-Seq_MCF-7_Human2.15111066
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.13924577
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.09278333
26CDX2_20551321_ChIP-Seq_CACO-2_Human2.00519939
27TP63_17297297_ChIP-ChIP_HaCaT_Human15.2246469
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98630567
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96803103
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.92933648
31SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.86980394
32SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.86980394
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.85732882
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85342917
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.76429853
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.76420196
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.75968010
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75216405
39ZNF274_21170338_ChIP-Seq_K562_Hela1.75142389
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73228501
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.68801968
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66395836
43ZNF263_19887448_ChIP-Seq_K562_Human1.65969539
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.65206104
45FOXP3_21729870_ChIP-Seq_TREG_Human1.64574805
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64475938
47VDR_23849224_ChIP-Seq_CD4+_Human1.62682759
48TCF3_18692474_ChIP-Seq_MEFs_Mouse1.58169679
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57950928
50NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.57691574
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56187945
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.54754295
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54642150
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.54559733
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54367103
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53594138
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52528799
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.49927330
59TTF2_22483619_ChIP-Seq_HELA_Human1.49816085
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47199312
61DCP1A_22483619_ChIP-Seq_HELA_Human1.46918505
62IGF1R_20145208_ChIP-Seq_DFB_Human1.46840459
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.46533421
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.42095752
65NANOG_18692474_ChIP-Seq_MEFs_Mouse1.41547984
66CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.40801520
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.39083769
68AR_21909140_ChIP-Seq_LNCAP_Human1.37346219
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36703553
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.35531099
71RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34686235
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34274194
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33616924
74CJUN_26792858_Chip-Seq_BT549_Human1.33196938
75SOX2_20726797_ChIP-Seq_SW620_Human1.31937258
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30659881
77IRF1_19129219_ChIP-ChIP_H3396_Human1.30540505
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.30110375
79GABP_19822575_ChIP-Seq_HepG2_Human1.29089801
80KLF5_25053715_ChIP-Seq_YYC3_Human1.27704280
81SOX2_18692474_ChIP-Seq_MEFs_Mouse1.25898116
82HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25755400
83RUNX1_27514584_Chip-Seq_MCF-7_Human1.21363591
84VDR_22108803_ChIP-Seq_LS180_Human1.20402724
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19288135
86ELK1_19687146_ChIP-ChIP_HELA_Human1.16646118
87MYC_18940864_ChIP-ChIP_HL60_Human1.12600936
88BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.11157532
89MYC_18555785_ChIP-Seq_MESCs_Mouse1.11040119
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10509901
91OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10171471
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07132268
93UBF1/2_26484160_Chip-Seq_HMECs_Human1.06971409
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03587707
95GATA3_24758297_ChIP-Seq_MCF-7_Human1.02987275
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02444884
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01058467
98SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00573403
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.99785832
100TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.99486729
101PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99074110
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98723770
103RNF2_27304074_Chip-Seq_NSC_Mouse0.97572359
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97131320
105SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97128164
106NANOG_16153702_ChIP-ChIP_HESCs_Human0.96634092
107EWS_26573619_Chip-Seq_HEK293_Human0.96232895
108GATA6_25053715_ChIP-Seq_YYC3_Human0.95635539
109BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95629405
110NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93027721
111TP53_22573176_ChIP-Seq_HFKS_Human0.92595900
112GATA4_25053715_ChIP-Seq_YYC3_Human0.92093607
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.91895428
114TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91780047
115ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91681696
116TP53_18474530_ChIP-ChIP_U2OS_Human0.91291116
117TCF3_18692474_ChIP-Seq_MESCs_Mouse0.89270054
118UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88649904
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88470856
120GABP_17652178_ChIP-ChIP_JURKAT_Human0.88333692
121SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88266612
122CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88211543
123SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.87792114
124ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.87575410
125HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86985851
126NANOG_18692474_ChIP-Seq_MESCs_Mouse0.85332497
127RACK7_27058665_Chip-Seq_MCF-7_Human0.85119798
128HTT_18923047_ChIP-ChIP_STHdh_Human0.84312460
129POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83420373
130SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.82296469
131KAP1_22055183_ChIP-Seq_ESCs_Mouse0.82039619
132JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81791620
133FLI1_27457419_Chip-Seq_LIVER_Mouse0.81689363
134ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81460410
135EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.81354787
136STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79087895
137E2F1_17053090_ChIP-ChIP_MCF-7_Human0.78515208
138GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.77671594
139XRN2_22483619_ChIP-Seq_HELA_Human0.77554931
140HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.77125896
141ZNF217_24962896_ChIP-Seq_MCF-7_Human0.76570376
142ATF3_27146783_Chip-Seq_COLON_Human0.76501586
143JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75793242
144SOX17_20123909_ChIP-Seq_XEN_Mouse0.75387273
145SOX2_16153702_ChIP-ChIP_HESCs_Human0.75324761
146PPAR_26484153_Chip-Seq_NCI-H1993_Human0.74968697
147AHR_22903824_ChIP-Seq_MCF-7_Human0.74351628
148SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.74336024
149RBPJ_21746931_ChIP-Seq_IB4_Human0.74320737
150SOX2_27498859_Chip-Seq_STOMACH_Mouse0.73657131
151EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.73421288
152EED_16625203_ChIP-ChIP_MESCs_Mouse0.72513829
153CLOCK_20551151_ChIP-Seq_293T_Human0.72349557
154ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.72349522
155FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.71771257
156* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.71750717
157CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.71456199
158NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71184922
159ESR1_15608294_ChIP-ChIP_MCF-7_Human0.70604408
160CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70214871
161HIF1A_21447827_ChIP-Seq_MCF-7_Human0.69632730
162E2F1_18555785_ChIP-Seq_MESCs_Mouse0.69471953
163GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.69405227
164ETS1_20019798_ChIP-Seq_JURKAT_Human0.69236088
165TP63_23658742_ChIP-Seq_EP156T_Human0.69165723
166CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.68844479
167ERG_20887958_ChIP-Seq_HPC-7_Mouse0.67148977
168PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.66936901
169FOXA1_25329375_ChIP-Seq_VCAP_Human0.66816714
170FOXA1_27270436_Chip-Seq_PROSTATE_Human0.66816714
171CREB1_15753290_ChIP-ChIP_HEK293T_Human0.66748445
172ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.66250602
173FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.66142996
174RBPJ_22232070_ChIP-Seq_NCS_Mouse0.66014691
175ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.65475797
176ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.64874723
177TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.64786972
178NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.64136840
179PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.63907381

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.65906042
2MP0002254_reproductive_system_inflammat5.09897244
3MP0000383_abnormal_hair_follicle5.00223105
4MP0004381_abnormal_hair_follicle4.27488999
5MP0009379_abnormal_foot_pigmentation4.12112557
6MP0010678_abnormal_skin_adnexa3.89562356
7MP0008058_abnormal_DNA_repair3.87793574
8MP0002796_impaired_skin_barrier3.85294588
9MP0001346_abnormal_lacrimal_gland3.83218050
10MP0003941_abnormal_skin_development3.69227895
11MP0010030_abnormal_orbit_morphology3.64457823
12MP0010368_abnormal_lymphatic_system3.47707754
13MP0010234_abnormal_vibrissa_follicle3.42164835
14MP0008789_abnormal_olfactory_epithelium3.38935989
15MP0002210_abnormal_sex_determination3.32507066
16MP0005394_taste/olfaction_phenotype3.19724862
17MP0005499_abnormal_olfactory_system3.19724862
18MP0008057_abnormal_DNA_replication2.99003523
19MP0001929_abnormal_gametogenesis2.95014694
20MP0002098_abnormal_vibrissa_morphology2.86947568
21MP0010094_abnormal_chromosome_stability2.83217058
22MP0003136_yellow_coat_color2.80337192
23MP0003111_abnormal_nucleus_morphology2.68590608
24MP0002160_abnormal_reproductive_system2.62016363
25MP0002009_preneoplasia2.61859018
26MP0003077_abnormal_cell_cycle2.55201603
27MP0000653_abnormal_sex_gland2.54076052
28MP0002877_abnormal_melanocyte_morpholog2.52708988
29MP0001145_abnormal_male_reproductive2.51531059
30MP0000566_synostosis2.47666356
31MP0000762_abnormal_tongue_morphology2.39418296
32MP0003453_abnormal_keratinocyte_physiol2.39292890
33MP0002060_abnormal_skin_morphology2.28960787
34MP0000467_abnormal_esophagus_morphology2.24698367
35MP0000647_abnormal_sebaceous_gland2.17742215
36MP0003698_abnormal_male_reproductive2.13438896
37MP0001216_abnormal_epidermal_layer1.98661297
38MP0005451_abnormal_body_composition1.88773984
39MP0003699_abnormal_female_reproductive1.88628525
40MP0000678_abnormal_parathyroid_gland1.87858517
41MP0005501_abnormal_skin_physiology1.84236096
42MP0008932_abnormal_embryonic_tissue1.80290041
43MP0000579_abnormal_nail_morphology1.79120573
44MP0003123_paternal_imprinting1.72840707
45MP0001730_embryonic_growth_arrest1.72705119
46MP0002161_abnormal_fertility/fecundity1.69418206
47MP0005409_darkened_coat_color1.68512858
48MP0001119_abnormal_female_reproductive1.66643094
49MP0005395_other_phenotype1.65638592
50MP0005389_reproductive_system_phenotype1.62455371
51MP0010771_integument_phenotype1.62289646
52MP0010307_abnormal_tumor_latency1.61606473
53MP0002277_abnormal_respiratory_mucosa1.61281630
54MP0002139_abnormal_hepatobiliary_system1.54727208
55MP0000613_abnormal_salivary_gland1.54004574
56MP0002233_abnormal_nose_morphology1.52295481
57MP0003938_abnormal_ear_development1.39884124
58MP0004782_abnormal_surfactant_physiolog1.37440633
59MP0003786_premature_aging1.37147148
60MP0005275_abnormal_skin_tensile1.37115186
61MP0000377_abnormal_hair_follicle1.36893839
62MP0002132_abnormal_respiratory_system1.36479876
63MP0008260_abnormal_autophagy1.35316714
64MP0001188_hyperpigmentation1.35301504
65MP0005410_abnormal_fertilization1.34333103
66MP0003693_abnormal_embryo_hatching1.33114539
67MP0000372_irregular_coat_pigmentation1.32712299
68MP0001984_abnormal_olfaction1.31672966
69MP0003567_abnormal_fetal_cardiomyocyte1.29657248
70MP0001666_abnormal_nutrient_absorption1.25640048
71MP0003950_abnormal_plasma_membrane1.23451851
72MP0002249_abnormal_larynx_morphology1.23322526
73MP0000350_abnormal_cell_proliferation1.21473503
74MP0000427_abnormal_hair_cycle1.21457096
75MP0003119_abnormal_digestive_system1.20084584
76MP0005023_abnormal_wound_healing1.18077612
77MP0005360_urolithiasis1.16406878
78MP0003828_pulmonary_edema1.15669995
79MP0008875_abnormal_xenobiotic_pharmacok1.15346559
80MP0003646_muscle_fatigue1.14927941
81MP0001293_anophthalmia1.14752826
82MP0004264_abnormal_extraembryonic_tissu1.13453107
83MP0003121_genomic_imprinting1.13318587
84MP0001672_abnormal_embryogenesis/_devel1.07728162
85MP0005380_embryogenesis_phenotype1.07728162
86MP0005647_abnormal_sex_gland1.07243412
87MP0005174_abnormal_tail_pigmentation1.06208547
88MP0003195_calcinosis1.02839943
89MP0009250_abnormal_appendicular_skeleto1.02599145
90MP0002084_abnormal_developmental_patter1.01992657
91MP0010352_gastrointestinal_tract_polyps1.00750557
92MP0002751_abnormal_autonomic_nervous0.98532873
93MP0004019_abnormal_vitamin_homeostasis0.98424214
94MP0002876_abnormal_thyroid_physiology0.95550165
95MP0002085_abnormal_embryonic_tissue0.95496375
96MP0006035_abnormal_mitochondrial_morpho0.94548930
97MP0000627_abnormal_mammary_gland0.93194276
98MP0001340_abnormal_eyelid_morphology0.92823975
99MP0001697_abnormal_embryo_size0.92673821
100MP0004947_skin_inflammation0.91489027
101MP0003186_abnormal_redox_activity0.90608680
102MP0000631_abnormal_neuroendocrine_gland0.88512382
103MP0000049_abnormal_middle_ear0.88346386
104MP0002295_abnormal_pulmonary_circulatio0.87600647
105MP0002006_tumorigenesis0.85214538
106MP0000537_abnormal_urethra_morphology0.85212731
107MP0003755_abnormal_palate_morphology0.82696659
108MP0001191_abnormal_skin_condition0.81005498
109MP0009931_abnormal_skin_appearance0.80291478
110MP0008995_early_reproductive_senescence0.79917063
111MP0003937_abnormal_limbs/digits/tail_de0.78321275
112MP0002166_altered_tumor_susceptibility0.76432597
113MP0000534_abnormal_ureter_morphology0.76220920
114MP0009278_abnormal_bone_marrow0.76012190
115MP0006072_abnormal_retinal_apoptosis0.75695162
116MP0003566_abnormal_cell_adhesion0.75465451
117MP0000313_abnormal_cell_death0.74597823
118MP0005075_abnormal_melanosome_morpholog0.74582554
119MP0002080_prenatal_lethality0.74013221
120MP0001853_heart_inflammation0.73883244
121MP0003183_abnormal_peptide_metabolism0.70925555
122MP0000681_abnormal_thyroid_gland0.70352966
123MP0001851_eye_inflammation0.69477857
124MP0000358_abnormal_cell_content/0.68253781
125MP0001986_abnormal_taste_sensitivity0.67713805
126MP0005408_hypopigmentation0.66905916
127MP0001177_atelectasis0.66532422
128MP0000367_abnormal_coat/_hair0.66110889
129MP0005551_abnormal_eye_electrophysiolog0.65607624
130MP0003984_embryonic_growth_retardation0.65406189
131MP0001661_extended_life_span0.65072394
132MP0000465_gastrointestinal_hemorrhage0.64363282
133MP0003315_abnormal_perineum_morphology0.64107932
134MP0002088_abnormal_embryonic_growth/wei0.63036888
135MP0001919_abnormal_reproductive_system0.62417504
136MP0004142_abnormal_muscle_tone0.61395017
137MP0001243_abnormal_dermal_layer0.60841652
138MP0002234_abnormal_pharynx_morphology0.60470938
139MP0003861_abnormal_nervous_system0.60447443
140MP0004147_increased_porphyrin_level0.59661237
141MP0009053_abnormal_anal_canal0.59600058
142MP0004197_abnormal_fetal_growth/weight/0.57877905
143MP0003942_abnormal_urinary_system0.57665445
144MP0003724_increased_susceptibility_to0.56371064
145MP0006292_abnormal_olfactory_placode0.56303485
146MP0001879_abnormal_lymphatic_vessel0.55778165
147MP0003718_maternal_effect0.55645191
148MP0003936_abnormal_reproductive_system0.54022645
149MP0002089_abnormal_postnatal_growth/wei0.52586511
150MP0008007_abnormal_cellular_replicative0.51428743
151MP0002177_abnormal_outer_ear0.51397309
152MP0001324_abnormal_eye_pigmentation0.50404655
153MP0001545_abnormal_hematopoietic_system0.48844796
154MP0005397_hematopoietic_system_phenotyp0.48844796
155MP0002095_abnormal_skin_pigmentation0.48226030
156MP0003890_abnormal_embryonic-extraembry0.48009299
157MP0003879_abnormal_hair_cell0.47772910
158MP0002163_abnormal_gland_morphology0.46441237
159MP0000428_abnormal_craniofacial_morphol0.46235512
160MP0000490_abnormal_crypts_of0.45984070
161MP0004957_abnormal_blastocyst_morpholog0.45572704
162MP0002697_abnormal_eye_size0.45501534
163MP0000538_abnormal_urinary_bladder0.45380666
164MP0003935_abnormal_craniofacial_develop0.44998379
165MP0002111_abnormal_tail_morphology0.44175013
166MP0005365_abnormal_bile_salt0.43931026
167MP0002090_abnormal_vision0.43414189
168MP0005508_abnormal_skeleton_morphology0.42241200
169MP0002133_abnormal_respiratory_system0.41764219

Predicted human phenotypes

RankGene SetZ-score
1Lip pit (HP:0100267)6.68081611
2Osteomalacia (HP:0002749)5.42051003
3Stenosis of the external auditory canal (HP:0000402)5.41097438
4Fragile nails (HP:0001808)4.61350498
5Abnormal hemoglobin (HP:0011902)4.47595064
6Hypotrichosis (HP:0001006)4.46372582
7Chromsome breakage (HP:0040012)4.44250007
8Supernumerary spleens (HP:0009799)4.38576166
9Plantar hyperkeratosis (HP:0007556)4.35991681
10Chromosomal breakage induced by crosslinking agents (HP:0003221)4.32193459
11Abnormality of the labia minora (HP:0012880)4.11742740
12Gonadotropin excess (HP:0000837)4.04717753
13Abnormality of the axillary hair (HP:0100134)3.98637808
14Abnormality of secondary sexual hair (HP:0009888)3.98637808
15Milia (HP:0001056)3.94706380
16Abnormality of cells of the erythroid lineage (HP:0012130)3.94376087
17Onycholysis (HP:0001806)3.77269345
18Sparse eyelashes (HP:0000653)3.66311110
19Parakeratosis (HP:0001036)3.58823080
20Volvulus (HP:0002580)3.55901967
21Congenital, generalized hypertrichosis (HP:0004540)3.53639663
22Reticulocytopenia (HP:0001896)3.50956166
23Conical tooth (HP:0000698)3.42055185
24Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.39869664
25Degeneration of the lateral corticospinal tracts (HP:0002314)3.39869664
26Abnormal lung lobation (HP:0002101)3.38425753
27Ridged nail (HP:0001807)3.35519914
28Atrophic scars (HP:0001075)3.30496353
29Nasolacrimal duct obstruction (HP:0000579)3.30058736
30Carpal bone hypoplasia (HP:0001498)3.29487900
31Oligodactyly (hands) (HP:0001180)3.26221509
32Palmoplantar hyperkeratosis (HP:0000972)3.23754797
33Azoospermia (HP:0000027)3.23020008
34Shoulder girdle muscle weakness (HP:0003547)3.19325948
35Sparse scalp hair (HP:0002209)3.19284173
36Palmar hyperkeratosis (HP:0010765)3.18253984
37Abnormal number of erythroid precursors (HP:0012131)3.16673106
38Thick nail (HP:0001805)3.12077415
39Natal tooth (HP:0000695)3.04846716
40Woolly hair (HP:0002224)3.01420193
41Down-sloping shoulders (HP:0200021)3.01194457
42Nail dystrophy (HP:0008404)3.00038978
43Selective tooth agenesis (HP:0001592)2.99889533
44Alopecia of scalp (HP:0002293)2.99117396
45Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.97559066
46Macrocytic anemia (HP:0001972)2.96022649
47Congenital ichthyosiform erythroderma (HP:0007431)2.94930420
48Agnosia (HP:0010524)2.92801840
49Right ventricular cardiomyopathy (HP:0011663)2.92207623
50Concave nail (HP:0001598)2.89504442
51Facial hemangioma (HP:0000329)2.89142961
52Short tibia (HP:0005736)2.87261350
53Septo-optic dysplasia (HP:0100842)2.83987175
54Meckel diverticulum (HP:0002245)2.80351446
55Ectopic kidney (HP:0000086)2.76791957
56Abnormality of the corticospinal tract (HP:0002492)2.76395039
57Abnormality of the lacrimal duct (HP:0011481)2.71159135
58Popliteal pterygium (HP:0009756)2.71071822
59Pili torti (HP:0003777)2.69393371
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.69301981
61Hypohidrosis (HP:0000966)2.66827527
62Bifid scrotum (HP:0000048)2.63912960
63Stomach cancer (HP:0012126)2.63621844
64Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.63572830
65Abnormal spermatogenesis (HP:0008669)2.62583803
66Abnormality of the ileum (HP:0001549)2.62039385
67Abnormality of chromosome stability (HP:0003220)2.61567339
68Rhabdomyosarcoma (HP:0002859)2.60613314
69Horseshoe kidney (HP:0000085)2.60240330
70Male infertility (HP:0003251)2.60209362
71Absent radius (HP:0003974)2.58988290
72Abdominal situs inversus (HP:0003363)2.56359348
73Abnormality of abdominal situs (HP:0011620)2.56359348
74Abnormality of the lower motor neuron (HP:0002366)2.55400006
75Cupped ear (HP:0000378)2.55232203
76Duodenal stenosis (HP:0100867)2.55191463
77Small intestinal stenosis (HP:0012848)2.55191463
78Corneal erosion (HP:0200020)2.53687861
79Abnormal blistering of the skin (HP:0008066)2.53464983
80Capillary hemangiomas (HP:0005306)2.49857519
81Impulsivity (HP:0100710)2.47196310
82Aplasia cutis congenita (HP:0001057)2.46621008
83Absent eyebrow (HP:0002223)2.45570278
84Amyotrophic lateral sclerosis (HP:0007354)2.45424288
85Absent septum pellucidum (HP:0001331)2.45381568
86Aplasia/Hypoplasia of the tibia (HP:0005772)2.44565069
87Aplasia involving bones of the upper limbs (HP:0009823)2.44440334
88Aplasia of the phalanges of the hand (HP:0009802)2.44440334
89Aplasia involving bones of the extremities (HP:0009825)2.44440334
90Premature ovarian failure (HP:0008209)2.43688429
91Morphological abnormality of the middle ear (HP:0008609)2.43662061
92Ependymoma (HP:0002888)2.43631411
93Median cleft lip (HP:0000161)2.43327297
94Septate vagina (HP:0001153)2.41964518
95Gonadal dysgenesis (HP:0000133)2.40444295
96Aplasia involving forearm bones (HP:0009822)2.39473833
97Absent forearm bone (HP:0003953)2.39473833
98Abnormality of the nasolacrimal system (HP:0000614)2.39257734
99Pallor (HP:0000980)2.35788464
100Split foot (HP:0001839)2.31826810
101Hyperglycinemia (HP:0002154)2.31115821
102Oligodactyly (HP:0012165)2.29244080
103Abnormality of the preputium (HP:0100587)2.28522091
104Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.28492408
105Rickets (HP:0002748)2.28178605
106Facial cleft (HP:0002006)2.27161467
107Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.26614229
108Abnormality of the phalanges of the 2nd finger (HP:0009541)2.25733622
109Hyperglycinuria (HP:0003108)2.25624716
110Oligodontia (HP:0000677)2.25226555
111Medulloblastoma (HP:0002885)2.24914203
112Sex reversal (HP:0012245)2.24790733
113Abnormal sex determination (HP:0012244)2.24790733
114Nephroblastoma (Wilms tumor) (HP:0002667)2.23533163
115Absent thumb (HP:0009777)2.21556410
116Esophageal atresia (HP:0002032)2.21313360
117Neoplasm of the oral cavity (HP:0100649)2.20677483
118Erythema (HP:0010783)2.18932777
119Trismus (HP:0000211)2.18376770
120Increased nuchal translucency (HP:0010880)2.15378921
121Papillary thyroid carcinoma (HP:0002895)2.14712331
122Biliary tract neoplasm (HP:0100574)2.13731972
123Hypophosphatemic rickets (HP:0004912)2.12435214
124Abnormality of the septum pellucidum (HP:0007375)2.11435676
125Aplasia/hypoplasia of the uterus (HP:0008684)2.11156660
126Embryonal renal neoplasm (HP:0011794)2.10851949
127Abnormality of the duodenum (HP:0002246)2.10178018
128Abnormality of nail color (HP:0100643)2.09734633
129Colon cancer (HP:0003003)2.08954487
130Hypoplastic labia majora (HP:0000059)2.08639853
131Duplication of thumb phalanx (HP:0009942)2.08245800
132Premature skin wrinkling (HP:0100678)2.07515953
133Metaphyseal irregularity (HP:0003025)2.07502527
134Abnormality of the phalanges of the 5th finger (HP:0004213)2.07299785
135Bicornuate uterus (HP:0000813)2.06639538
136Abnormality of cochlea (HP:0000375)2.05773618
137Blepharitis (HP:0000498)2.05653235
138Asymmetry of the thorax (HP:0001555)2.05459532
139Delayed epiphyseal ossification (HP:0002663)2.04484971
140Breast hypoplasia (HP:0003187)2.04323350
141Rimmed vacuoles (HP:0003805)2.04278693
142Partial duplication of thumb phalanx (HP:0009944)2.03570540
143Advanced eruption of teeth (HP:0006288)2.03505030
144Hypoplastic nipples (HP:0002557)2.02574330
145Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.02046016
146Horizontal nystagmus (HP:0000666)2.01374123
147Cleft eyelid (HP:0000625)1.99529105
148Infertility (HP:0000789)1.99461287
149Pruritus (HP:0000989)1.99105731
150Proximal tubulopathy (HP:0000114)1.98970864
151Hypoplasia of the ulna (HP:0003022)1.98860190
152Pterygium (HP:0001059)1.98277244
153Seborrheic dermatitis (HP:0001051)1.98155030
154Dry hair (HP:0011359)1.96675657
155Cheilitis (HP:0100825)1.96151999
156Acanthosis nigricans (HP:0000956)1.95738120
157Distal lower limb muscle weakness (HP:0009053)1.95675558
158Pustule (HP:0200039)1.95646038
159Cutaneous finger syndactyly (HP:0010554)1.95496962
160Upper motor neuron abnormality (HP:0002127)1.95195260
161Impaired vibration sensation in the lower limbs (HP:0002166)1.95100034
162Hypercortisolism (HP:0001578)1.94402431
163Abnormality of DNA repair (HP:0003254)1.93795829
164Abnormality of glycine metabolism (HP:0010895)1.92520636
165Abnormality of serine family amino acid metabolism (HP:0010894)1.92520636
166Preauricular pit (HP:0004467)1.92442485
167Periauricular skin pits (HP:0100277)1.92442485
168Abnormality of the renal collecting system (HP:0004742)1.91561502
169Atrophy/Degeneration involving motor neurons (HP:0007373)1.90693894
170Renal dysplasia (HP:0000110)1.89340893
171Hypoplasia of the uterus (HP:0000013)1.89149585
172Ventricular tachycardia (HP:0004756)1.88307463
173Enlarged penis (HP:0000040)1.87888535
174Scotoma (HP:0000575)1.87813730
175Abnormality of the 2nd finger (HP:0004100)1.87031797
176Abnormal hair laboratory examination (HP:0003328)1.86543593
177Triphalangeal thumb (HP:0001199)1.86337555
178Birth length less than 3rd percentile (HP:0003561)1.86262487
179Rectovaginal fistula (HP:0000143)1.85589595
180Rectal fistula (HP:0100590)1.85589595
181Abnormality of the labia majora (HP:0012881)1.85236062
182Abnormal umbilical cord blood vessels (HP:0011403)1.84828522
183Single umbilical artery (HP:0001195)1.84828522
184Abnormality of the fetal cardiovascular system (HP:0010948)1.84828522
185Hypodontia (HP:0000668)1.84764543
186Embryonal neoplasm (HP:0002898)1.83738616
187Skin pits (HP:0100276)1.83730777
188Abnormality of the fovea (HP:0000493)1.81238969
189Neoplasm of the colon (HP:0100273)1.81164512
190Aplasia/Hypoplasia of the sternum (HP:0006714)1.78584298
191Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77953025

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.07887505
2CDK194.46032430
3ACVR1B4.30989841
4PNCK4.19301085
5MST44.14922176
6MAP3K34.02087085
7RPS6KB23.81743367
8CDC73.31811770
9ZAK3.28578686
10MAP3K93.26981027
11ARAF2.93661771
12MAP2K22.66487180
13PBK2.56421740
14MST1R2.56000197
15MAPKAPK32.54081315
16BRAF2.38803740
17MAP3K22.33503999
18PLK12.17922338
19MAP3K132.17504554
20IRAK32.06640427
21BUB12.00060095
22MAPK151.90836470
23WEE11.84853025
24NME21.82789284
25STK38L1.76535551
26MAP3K11.68588393
27STK101.57632465
28MAP2K61.57238608
29EIF2AK31.55597041
30KSR21.53831116
31STK31.53585214
32BRSK11.47150644
33CDK71.44068893
34FGFR21.38671816
35LRRK21.38530810
36ERBB31.36051927
37CDK91.35268991
38STK161.35176820
39FER1.34009628
40TRPM71.28299668
41TESK11.26581607
42STK241.26048906
43RAF11.24406023
44CDK121.22261895
45NME11.22000029
46MAP3K111.21600435
47TTK1.21377709
48WNK11.19578358
49MAPKAPK51.18463700
50ATR1.16044017
51PDK21.15339370
52VRK11.15111276
53MET1.14649891
54CHEK21.13672945
55CHEK11.12271052
56TAF11.12023011
57EPHA41.10266651
58TNK21.06766816
59STK391.02680584
60ATM1.02010504
61TAOK21.01262051
62CDK81.00728234
63RPS6KA41.00659568
64MAP2K30.99160142
65AURKA0.98988933
66NEK20.96918253
67IRAK20.96772250
68MAP3K120.95947030
69BMPR1B0.95393628
70PIM20.93687280
71PLK40.93406012
72CLK10.91970339
73TYK20.91736521
74TAOK10.91066936
75NTRK30.90169787
76TIE10.87793073
77NLK0.86659111
78WNK40.84929852
79RPS6KL10.82850155
80RPS6KC10.82850155
81RIPK10.81952029
82RPS6KA60.81352651
83PRKCI0.81336690
84MAP2K10.80732478
85MARK10.80217842
86EPHB20.79144156
87MATK0.78602392
88CDK40.76316883
89MKNK20.75907857
90GRK70.75459187
91RPS6KA20.74611814
92VRK20.73508766
93IRAK40.72553435
94IKBKB0.71567237
95NEK90.70241955
96CDK20.69903493
97CAMK1G0.69729830
98PIM10.69493675
99BMPR20.69482682
100BRSK20.69400332
101MAPKAPK20.68877291
102MOS0.68866803
103LATS10.68093356
104KSR10.63749347
105PASK0.63506401
106PLK30.60730948
107DYRK20.60384884
108RPS6KA50.60166275
109CDK10.60064535
110CHUK0.59296532
111MELK0.58440827
112ADRBK20.58216979
113SRPK10.57666158
114NUAK10.57561293
115CDK30.55563715
116YES10.55228374
117AKT30.54559656
118PINK10.53734957
119TYRO30.51801450
120CSNK2A20.51319852
121TRIM280.50825932
122IRAK10.50470206
123MKNK10.49762185
124OXSR10.49510744
125HIPK20.49051478
126INSRR0.48909497
127CSNK1G10.47770269
128MAP3K50.46483339
129EIF2AK20.45741090
130ADRBK10.43955538
131NTRK20.43614931
132TSSK60.43514151
133TGFBR10.43068424
134PRKG10.43056562
135CSNK1G20.41963470
136EGFR0.41700890
137BCKDK0.41055678
138RPS6KB10.39924299
139PLK20.38946398
140CAMK10.38571150
141TAOK30.37758885
142RPS6KA10.37090086
143PRKDC0.36668906
144CDK60.34535981
145WNK30.32363034
146ROCK20.32036413
147PAK10.31790101
148MAP3K40.30726146
149DYRK30.30530125
150CDK11A0.30235281
151TGFBR20.30012456
152BMX0.29628242
153AURKB0.29580674
154FGR0.29485346
155CSNK1D0.28647057
156STK380.28451445
157CSNK2A10.27505631
158DYRK1A0.26662052
159CSNK1E0.26393162
160PRKCE0.26383731
161IKBKE0.26145432
162LATS20.25579405
163STK40.25508171
164MAP3K80.25074656
165SGK10.25027369
166PRKACB0.24602106
167MAPK70.23940075
168MAP3K140.22373843
169PRKCA0.21040262
170ABL20.20834162
171NEK60.20559332
172MAPK30.20092081

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.59338630
2Mismatch repair_Homo sapiens_hsa034305.34006876
3DNA replication_Homo sapiens_hsa030304.80068504
4Sulfur metabolism_Homo sapiens_hsa009204.02422781
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.98910433
6Cyanoamino acid metabolism_Homo sapiens_hsa004603.74657573
7Base excision repair_Homo sapiens_hsa034103.72085069
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.60735593
9Cell cycle_Homo sapiens_hsa041103.54438517
10Basal transcription factors_Homo sapiens_hsa030223.49837524
11Pentose and glucuronate interconversions_Homo sapiens_hsa000403.30435583
12Chemical carcinogenesis_Homo sapiens_hsa052043.24346890
13Homologous recombination_Homo sapiens_hsa034403.21803960
14Glutathione metabolism_Homo sapiens_hsa004803.12645148
15Fanconi anemia pathway_Homo sapiens_hsa034602.87895696
16Nucleotide excision repair_Homo sapiens_hsa034202.87192181
17Proteasome_Homo sapiens_hsa030502.81129677
18Steroid hormone biosynthesis_Homo sapiens_hsa001402.81045943
19Oocyte meiosis_Homo sapiens_hsa041142.35183559
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.26125563
21RNA polymerase_Homo sapiens_hsa030202.24270730
22Non-homologous end-joining_Homo sapiens_hsa034502.23690707
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.01927900
24Sulfur relay system_Homo sapiens_hsa041221.99827938
25Retinol metabolism_Homo sapiens_hsa008301.94544678
26Arachidonic acid metabolism_Homo sapiens_hsa005901.89587848
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.77023157
28mRNA surveillance pathway_Homo sapiens_hsa030151.76410561
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.74350148
30Butanoate metabolism_Homo sapiens_hsa006501.71626167
31Circadian rhythm_Homo sapiens_hsa047101.59038152
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56815200
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.56700693
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52705439
35Linoleic acid metabolism_Homo sapiens_hsa005911.50944314
36Dorso-ventral axis formation_Homo sapiens_hsa043201.47692252
37Sphingolipid metabolism_Homo sapiens_hsa006001.47626099
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43296097
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.42851524
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.29896565
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.24114613
42Steroid biosynthesis_Homo sapiens_hsa001001.22611326
43Fatty acid elongation_Homo sapiens_hsa000621.21140079
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.17190977
45Propanoate metabolism_Homo sapiens_hsa006401.12790369
46Asthma_Homo sapiens_hsa053101.12193867
47Folate biosynthesis_Homo sapiens_hsa007901.11642131
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10796214
49Basal cell carcinoma_Homo sapiens_hsa052171.08016092
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05516269
51Hedgehog signaling pathway_Homo sapiens_hsa043401.04789156
52Galactose metabolism_Homo sapiens_hsa000521.03973322
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99517632
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98096622
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96275707
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93728860
57Purine metabolism_Homo sapiens_hsa002300.92285783
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92192444
59Tight junction_Homo sapiens_hsa045300.89512554
60Hippo signaling pathway_Homo sapiens_hsa043900.87163984
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80839878
62Ether lipid metabolism_Homo sapiens_hsa005650.80254612
63Oxidative phosphorylation_Homo sapiens_hsa001900.78901983
64p53 signaling pathway_Homo sapiens_hsa041150.78722027
65Vitamin digestion and absorption_Homo sapiens_hsa049770.77760806
66Vitamin B6 metabolism_Homo sapiens_hsa007500.75811925
67RNA degradation_Homo sapiens_hsa030180.75722388
68One carbon pool by folate_Homo sapiens_hsa006700.73111829
69Phototransduction_Homo sapiens_hsa047440.71712869
70Phenylalanine metabolism_Homo sapiens_hsa003600.71707528
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69870363
72Pyrimidine metabolism_Homo sapiens_hsa002400.69551726
73Peroxisome_Homo sapiens_hsa041460.68555861
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67993340
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.63828140
76RNA transport_Homo sapiens_hsa030130.58741205
77ECM-receptor interaction_Homo sapiens_hsa045120.57497440
78Rheumatoid arthritis_Homo sapiens_hsa053230.56690658
79ABC transporters_Homo sapiens_hsa020100.56178779
80Prostate cancer_Homo sapiens_hsa052150.56104920
81Fat digestion and absorption_Homo sapiens_hsa049750.55540643
82Olfactory transduction_Homo sapiens_hsa047400.55108236
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54975071
84Huntingtons disease_Homo sapiens_hsa050160.54350513
85TGF-beta signaling pathway_Homo sapiens_hsa043500.53455889
86Mineral absorption_Homo sapiens_hsa049780.51632303
87Adherens junction_Homo sapiens_hsa045200.51539681
88Cardiac muscle contraction_Homo sapiens_hsa042600.50734591
89Arginine and proline metabolism_Homo sapiens_hsa003300.50645091
90Selenocompound metabolism_Homo sapiens_hsa004500.47105223
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46369416
92Pyruvate metabolism_Homo sapiens_hsa006200.44353354
93Histidine metabolism_Homo sapiens_hsa003400.44227348
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.43983192
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43727230
96Ovarian steroidogenesis_Homo sapiens_hsa049130.41708785
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.40716683
98Spliceosome_Homo sapiens_hsa030400.40702233
99Protein export_Homo sapiens_hsa030600.40693607
100Fatty acid degradation_Homo sapiens_hsa000710.40538129
101Parkinsons disease_Homo sapiens_hsa050120.40120693
102Epstein-Barr virus infection_Homo sapiens_hsa051690.39628125
103Nicotine addiction_Homo sapiens_hsa050330.38656210
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.37722257
105Fructose and mannose metabolism_Homo sapiens_hsa000510.36804811
106Collecting duct acid secretion_Homo sapiens_hsa049660.36597168
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36175285
108Regulation of autophagy_Homo sapiens_hsa041400.35846837
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35771457
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35640443
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35452749
112Small cell lung cancer_Homo sapiens_hsa052220.34694986
113HTLV-I infection_Homo sapiens_hsa051660.33846626
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31000173
115Bladder cancer_Homo sapiens_hsa052190.30704484
116Proteoglycans in cancer_Homo sapiens_hsa052050.30078112
117Tyrosine metabolism_Homo sapiens_hsa003500.29739065
118Fatty acid metabolism_Homo sapiens_hsa012120.29001389
119Caffeine metabolism_Homo sapiens_hsa002320.28859165
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28197561
121Metabolic pathways_Homo sapiens_hsa011000.28056663
122Amoebiasis_Homo sapiens_hsa051460.27365286
123mTOR signaling pathway_Homo sapiens_hsa041500.26878370
124N-Glycan biosynthesis_Homo sapiens_hsa005100.26688965
125beta-Alanine metabolism_Homo sapiens_hsa004100.24707821
126Thyroid cancer_Homo sapiens_hsa052160.23599670
127Alzheimers disease_Homo sapiens_hsa050100.23536680
128TNF signaling pathway_Homo sapiens_hsa046680.22839577
129Hepatitis C_Homo sapiens_hsa051600.22416040
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.22350896
131Axon guidance_Homo sapiens_hsa043600.21716275
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21164505
133Starch and sucrose metabolism_Homo sapiens_hsa005000.20236175
134Melanogenesis_Homo sapiens_hsa049160.20135062
135NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19843549
136Notch signaling pathway_Homo sapiens_hsa043300.19106090
137MicroRNAs in cancer_Homo sapiens_hsa052060.15541995
138Gap junction_Homo sapiens_hsa045400.14337794
139Glycerolipid metabolism_Homo sapiens_hsa005610.13464756
140Pathways in cancer_Homo sapiens_hsa052000.13148692
141Prolactin signaling pathway_Homo sapiens_hsa049170.13145491
142Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.12688306
143Wnt signaling pathway_Homo sapiens_hsa043100.12534192
144Toxoplasmosis_Homo sapiens_hsa051450.12358483
145Lysine degradation_Homo sapiens_hsa003100.10342301
146Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.08204048
147Inositol phosphate metabolism_Homo sapiens_hsa005620.08087159
148Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.08070354
149Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.06749254
150Arginine biosynthesis_Homo sapiens_hsa002200.05717202
151Taste transduction_Homo sapiens_hsa047420.05299794
152Protein digestion and absorption_Homo sapiens_hsa049740.05039551
153Melanoma_Homo sapiens_hsa052180.04684622
154Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.01521568

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