GPHB5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: GPHB5 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exocrine pancreas development (GO:0031017)9.31613331
2barbed-end actin filament capping (GO:0051016)9.27065139
3peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)7.96869270
4regulation of respiratory burst (GO:0060263)7.90533637
5cellular response to cadmium ion (GO:0071276)7.67125852
6opsonization (GO:0008228)7.18869005
7positive regulation of macrophage cytokine production (GO:0060907)6.96542723
8male sex determination (GO:0030238)6.79099106
9protein heterotetramerization (GO:0051290)6.67711597
10keratan sulfate catabolic process (GO:0042340)5.93726673
11positive regulation of glycolytic process (GO:0045821)5.81481758
12phosphorylated carbohydrate dephosphorylation (GO:0046838)5.52863732
13inositol phosphate dephosphorylation (GO:0046855)5.52863732
14positive regulation of glycogen biosynthetic process (GO:0045725)5.47362946
15response to folic acid (GO:0051593)5.34155680
16inositol phosphate catabolic process (GO:0071545)5.06016610
17necroptotic process (GO:0070266)4.94156094
18dermatan sulfate biosynthetic process (GO:0030208)4.83956776
19positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610814.78481715
20positive regulation of glycogen metabolic process (GO:0070875)4.71162999
21positive regulation of smoothened signaling pathway (GO:0045880)4.67637720
22production of molecular mediator involved in inflammatory response (GO:0002532)4.53777092
23regulation of macrophage cytokine production (GO:0010935)4.50517217
24nucleoside diphosphate catabolic process (GO:0009134)4.46404081
25dermatan sulfate metabolic process (GO:0030205)4.43591729
26actin filament capping (GO:0051693)4.32373347
27activation of protein kinase B activity (GO:0032148)4.14199907
28protein heterotrimerization (GO:0070208)4.02121038
29negative regulation of actin filament depolymerization (GO:0030835)3.86118979
30glomerulus development (GO:0032835)3.75587113
31modulation by virus of host morphology or physiology (GO:0019048)3.68318043
32positive regulation of nitric oxide biosynthetic process (GO:0045429)3.68113738
33defense response to fungus (GO:0050832)3.63655138
34sex determination (GO:0007530)3.62472548
35chondroitin sulfate catabolic process (GO:0030207)3.59799184
36regulation of female receptivity (GO:0045924)3.58186126
37mitotic cytokinesis (GO:0000281)3.56296886
38response to prostaglandin E (GO:0034695)3.51397932
39myeloid leukocyte mediated immunity (GO:0002444)3.43937694
40definitive hemopoiesis (GO:0060216)3.43652592
41keratan sulfate biosynthetic process (GO:0018146)3.42603376
42sulfur compound catabolic process (GO:0044273)3.37894580
43keratan sulfate metabolic process (GO:0042339)3.30217367
44positive regulation of prostaglandin secretion (GO:0032308)3.29227088
45positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.13410663
46programmed necrotic cell death (GO:0097300)3.08378018
47phosphatidylinositol dephosphorylation (GO:0046856)3.06065502
48regulation of glycolytic process (GO:0006110)2.98069894
49positive regulation of viral genome replication (GO:0045070)2.96361287
50regulation of actin filament depolymerization (GO:0030834)2.94503761
51positive regulation of interleukin-17 production (GO:0032740)2.92183711
52phospholipid dephosphorylation (GO:0046839)2.90333757
53female mating behavior (GO:0060180)2.88756800
54necrotic cell death (GO:0070265)2.88566227
55negative regulation of actin filament polymerization (GO:0030837)2.88280515
56mitochondrial calcium ion transport (GO:0006851)2.80917555
57oligodendrocyte development (GO:0014003)2.80685061
58drug transmembrane transport (GO:0006855)2.78483487
59regulation of prostaglandin secretion (GO:0032306)2.78269850
60positive regulation of DNA-templated transcription, initiation (GO:2000144)2.77572987
61cytoskeleton-dependent cytokinesis (GO:0061640)2.77546633
62regulation of plasminogen activation (GO:0010755)2.77012519
63indolalkylamine metabolic process (GO:0006586)2.76458227
64polyol catabolic process (GO:0046174)2.75315806
65regulation of nitric oxide biosynthetic process (GO:0045428)2.75122898
66keratinocyte development (GO:0003334)2.74458538
67response to prostaglandin (GO:0034694)2.71619987
68lateral sprouting from an epithelium (GO:0060601)2.69458028
69positive regulation of hormone biosynthetic process (GO:0046886)2.68371476
70modification by symbiont of host morphology or physiology (GO:0044003)2.68051001
71positive regulation of glucose import (GO:0046326)2.64773555
72positive regulation of cell-substrate adhesion (GO:0010811)2.62972921
73positive regulation of natural killer cell differentiation (GO:0032825)2.58189533
74type I interferon signaling pathway (GO:0060337)2.57606082
75cellular response to type I interferon (GO:0071357)2.57606082
76regulation of glycogen biosynthetic process (GO:0005979)2.57457064
77regulation of glucan biosynthetic process (GO:0010962)2.57457064
78cellular response to interleukin-6 (GO:0071354)2.55750339
79regulation of activation of Janus kinase activity (GO:0010533)2.52137068
80response to type I interferon (GO:0034340)2.49972077
81glycosaminoglycan catabolic process (GO:0006027)2.48625872
82dendritic cell migration (GO:0036336)2.47068930
83regulation of dendritic cell antigen processing and presentation (GO:0002604)2.46095573
84positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.45600136
85glycosaminoglycan biosynthetic process (GO:0006024)2.44757093
86behavioral response to ethanol (GO:0048149)2.43857730
87membrane assembly (GO:0071709)2.43774660
88histone H3-K36 demethylation (GO:0070544)2.42041787
89response to cadmium ion (GO:0046686)2.40006222
90aminoglycan catabolic process (GO:0006026)2.39890199
91substrate-dependent cell migration (GO:0006929)2.39210172
92peptidyl-glutamic acid carboxylation (GO:0017187)2.38893921
93protein carboxylation (GO:0018214)2.38893921
94aminoglycan biosynthetic process (GO:0006023)2.38726784
95response to interferon-alpha (GO:0035455)2.37985532
96quinone metabolic process (GO:1901661)2.37746848
97response to copper ion (GO:0046688)2.36551082
98planar cell polarity pathway involved in neural tube closure (GO:0090179)2.36344135
99positive regulation of respiratory burst (GO:0060267)18.0192433
100peptidyl-tyrosine autophosphorylation (GO:0038083)10.3747229

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.10988564
2AR_21572438_ChIP-Seq_LNCaP_Human3.88265034
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.53620779
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.18829602
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.93874699
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.83953878
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.31637024
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.27378266
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.21937207
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.21008967
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.10652333
12DROSHA_22980978_ChIP-Seq_HELA_Human2.07831801
13GATA1_22025678_ChIP-Seq_K562_Human11.9779795
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.97909590
15HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.97815331
16EED_16625203_ChIP-ChIP_MESCs_Mouse1.96032849
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.92543712
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.89540128
19VDR_22108803_ChIP-Seq_LS180_Human1.87552662
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87118117
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.86988542
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.83288396
23GBX2_23144817_ChIP-Seq_PC3_Human1.82240262
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79366484
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79366484
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.75973026
27TP53_18474530_ChIP-ChIP_U2OS_Human1.72035858
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53695016
29TP53_16413492_ChIP-PET_HCT116_Human1.44401445
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40455325
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37700060
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.35694359
33CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.32650736
34TP53_20018659_ChIP-ChIP_R1E_Mouse1.32611240
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.29201026
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.27953645
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27426975
38AR_25329375_ChIP-Seq_VCAP_Human1.18470957
39SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.16142884
40BCAT_22108803_ChIP-Seq_LS180_Human1.15498687
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14667893
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14653670
43BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12962195
44AHR_22903824_ChIP-Seq_MCF-7_Human1.12576185
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.11323255
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10299295
47CJUN_26792858_Chip-Seq_BT549_Human1.09832170
48VDR_24787735_ChIP-Seq_THP-1_Human1.09287710
49ER_23166858_ChIP-Seq_MCF-7_Human1.07193302
50P300_19829295_ChIP-Seq_ESCs_Human1.00775366
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00228244
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99769197
53CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99437609
54SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94764840
55EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93957263
56FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.92897671
57SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90144064
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89171599
59IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87256905
60SOX2_20726797_ChIP-Seq_SW620_Human0.86960802
61* RUNX2_22187159_ChIP-Seq_PCA_Human0.86927980
62* TAL1_26923725_Chip-Seq_HPCs_Mouse0.85722774
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.85622019
64RING1B_27294783_Chip-Seq_NPCs_Mouse0.85552227
65FUS_26573619_Chip-Seq_HEK293_Human0.84610218
66SMAD3_21741376_ChIP-Seq_EPCs_Human0.84463528
67* FLI1_21867929_ChIP-Seq_TH2_Mouse0.84459060
68TAF15_26573619_Chip-Seq_HEK293_Human0.83057792
69TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.82928414
70* P300_27268052_Chip-Seq_Bcells_Human0.80421028
71RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80392856
72* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79096363
73PIAS1_25552417_ChIP-Seq_VCAP_Human0.78298832
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.78239251
75* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.77752937
76ARNT_22903824_ChIP-Seq_MCF-7_Human0.77406877
77ESR1_20079471_ChIP-ChIP_T-47D_Human0.76713366
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.76473611
79CRX_20693478_ChIP-Seq_RETINA_Mouse0.76269547
80SMAD4_21799915_ChIP-Seq_A2780_Human0.74046487
81RING1B_27294783_Chip-Seq_ESCs_Mouse0.73856440
82CDX2_19796622_ChIP-Seq_MESCs_Mouse0.73237202
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.71085878
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.70381516
85JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69915496
86* PRDM14_20953172_ChIP-Seq_ESCs_Human0.69325571
87FOXM1_26456572_ChIP-Seq_MCF-7_Human0.69286585
88PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.68806008
89EZH2_27294783_Chip-Seq_NPCs_Mouse0.67977910
90TP63_17297297_ChIP-ChIP_HaCaT_Human0.67813499
91KLF5_25053715_ChIP-Seq_YYC3_Human0.67611569
92* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.66914064
93* LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.65410161
94CTBP2_25329375_ChIP-Seq_LNCAP_Human0.64839169
95* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.64069143
96POU5F1_16153702_ChIP-ChIP_HESCs_Human0.64019356
97ESR1_21235772_ChIP-Seq_MCF-7_Human0.63792715
98PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.63411590
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.63234149
100OCT4_21477851_ChIP-Seq_ESCs_Mouse0.62222773

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005084_abnormal_gallbladder_morpholo5.50461355
2MP0005275_abnormal_skin_tensile4.90965322
3MP0008438_abnormal_cutaneous_collagen4.70412463
4MP0005365_abnormal_bile_salt4.00938753
5MP0004147_increased_porphyrin_level3.58249135
6MP0003941_abnormal_skin_development3.03723998
7MP0002108_abnormal_muscle_morphology2.95881711
8MP0003950_abnormal_plasma_membrane2.93689445
9MP0005623_abnormal_meninges_morphology2.66872324
10MP0005508_abnormal_skeleton_morphology2.46112675
11MP0009764_decreased_sensitivity_to2.26263081
12MP0005503_abnormal_tendon_morphology10.1676875
13MP0003724_increased_susceptibility_to1.98713728
14MP0000749_muscle_degeneration1.97090159
15MP0003566_abnormal_cell_adhesion1.78872456
16MP0000751_myopathy1.75017247
17MP0003385_abnormal_body_wall1.72810963
18MP0004272_abnormal_basement_membrane1.71775832
19MP0001346_abnormal_lacrimal_gland1.69752594
20MP0003075_altered_response_to1.57155044
21MP0010386_abnormal_urinary_bladder1.48749371
22MP0004859_abnormal_synaptic_plasticity1.48033595
23MP0003252_abnormal_bile_duct1.47239992
24MP0008875_abnormal_xenobiotic_pharmacok1.46441824
25MP0002876_abnormal_thyroid_physiology1.37972562
26MP0005390_skeleton_phenotype1.36710404
27MP0005646_abnormal_pituitary_gland1.29875377
28MP0001533_abnormal_skeleton_physiology1.29002140
29MP0005023_abnormal_wound_healing1.27184292
30MP0002138_abnormal_hepatobiliary_system1.22063170
31MP0005165_increased_susceptibility_to1.20005887
32MP0000685_abnormal_immune_system1.19309922
33MP0001958_emphysema1.16445307
34MP0001756_abnormal_urination1.12174556
35MP0005451_abnormal_body_composition1.12102132
36MP0002295_abnormal_pulmonary_circulatio1.11124737
37MP0003763_abnormal_thymus_physiology1.08182780
38MP0001293_anophthalmia1.06942631
39MP0009780_abnormal_chondrocyte_physiolo1.04104765
40MP0001790_abnormal_immune_system1.03605422
41MP0005387_immune_system_phenotype1.03605422
42MP0010368_abnormal_lymphatic_system1.03422859
43MP0000613_abnormal_salivary_gland1.02325627
44MP0009765_abnormal_xenobiotic_induced1.00195011
45MP0008961_abnormal_basal_metabolism0.99908512
46MP0002249_abnormal_larynx_morphology0.99778458
47MP0005171_absent_coat_pigmentation0.99686526
48MP0002998_abnormal_bone_remodeling0.96135369
49MP0002115_abnormal_skeleton_extremities0.94299754
50MP0009672_abnormal_birth_weight0.91421327
51MP0000163_abnormal_cartilage_morphology0.90448931
52MP0001243_abnormal_dermal_layer0.90143925
53MP0006054_spinal_hemorrhage0.89630350
54MP0005257_abnormal_intraocular_pressure0.87455060
55MP0003279_aneurysm0.86001565
56MP0003938_abnormal_ear_development0.85510047
57MP0008260_abnormal_autophagy0.79884816
58MP0001348_abnormal_lacrimal_gland0.77102497
59MP0000920_abnormal_myelination0.75813297
60MP0009703_decreased_birth_body0.73957022
61MP0002113_abnormal_skeleton_development0.73049814
62MP0000538_abnormal_urinary_bladder0.70606436
63MP0001286_abnormal_eye_development0.70566851
64MP0000858_altered_metastatic_potential0.70294964
65MP0002139_abnormal_hepatobiliary_system0.69301916
66MP0006035_abnormal_mitochondrial_morpho0.68513278
67MP0003122_maternal_imprinting0.66638963
68MP0002419_abnormal_innate_immunity0.66481977
69MP0005334_abnormal_fat_pad0.64635779
70MP0002089_abnormal_postnatal_growth/wei0.64608715
71MP0002060_abnormal_skin_morphology0.61103205
72MP0000358_abnormal_cell_content/0.59946305
73MP0000470_abnormal_stomach_morphology0.58695675
74MP0000534_abnormal_ureter_morphology0.57853969
75MP0002109_abnormal_limb_morphology0.57623882
76MP0009785_altered_susceptibility_to0.56597352
77MP0002092_abnormal_eye_morphology0.55312529
78MP0002163_abnormal_gland_morphology0.54631002
79MP0001119_abnormal_female_reproductive0.54296242
80MP0005671_abnormal_response_to0.53071802
81MP0003091_abnormal_cell_migration0.52915438
82MP0000627_abnormal_mammary_gland0.51474883
83MP0000767_abnormal_smooth_muscle0.51077518
84MP0002136_abnormal_kidney_physiology0.49527699
85MP0000681_abnormal_thyroid_gland0.48731989
86MP0002933_joint_inflammation0.48455536
87MP0002069_abnormal_eating/drinking_beha0.48347064
88MP0008469_abnormal_protein_level0.48166464
89MP0003795_abnormal_bone_structure0.46890192
90MP0002272_abnormal_nervous_system0.46781623
91MP0001835_abnormal_antigen_presentation0.45653148
92MP0005025_abnormal_response_to0.45469032
93MP0000249_abnormal_blood_vessel0.45454861
94MP0000013_abnormal_adipose_tissue0.44837719
95MP0002168_other_aberrant_phenotype0.44342571
96MP0003011_delayed_dark_adaptation0.43698514
97MP0000467_abnormal_esophagus_morphology0.42915523
98MP0003879_abnormal_hair_cell0.42558027
99MP0005369_muscle_phenotype0.41304217
100MP0009643_abnormal_urine_homeostasis0.40665655

Predicted human phenotypes

RankGene SetZ-score
1Neonatal short-limb short stature (HP:0008921)7.97330259
2Ileus (HP:0002595)7.21458478
3Pancreatic islet-cell hyperplasia (HP:0004510)6.92070680
4Long foot (HP:0001833)6.58357100
5Chronic hepatic failure (HP:0100626)6.16203837
6Hypoglycemic seizures (HP:0002173)5.94671304
7Enlarged penis (HP:0000040)5.91018749
8Thick nail (HP:0001805)5.89396793
9Advanced eruption of teeth (HP:0006288)5.79181634
10Conical tooth (HP:0000698)5.78977410
11Natal tooth (HP:0000695)5.60686067
12Abnormal number of incisors (HP:0011064)5.58155905
13Congenital, generalized hypertrichosis (HP:0004540)5.19198458
14Mild short stature (HP:0003502)5.12467031
15Elfin facies (HP:0004428)5.11887628
16Retinal dysplasia (HP:0007973)5.09109790
17Hyperinsulinemic hypoglycemia (HP:0000825)4.95194925
18Hypoglycemic coma (HP:0001325)4.94061467
19Scanning speech (HP:0002168)4.38245207
20Symptomatic seizures (HP:0011145)4.30394003
21Abnormality of the pancreatic islet cells (HP:0006476)4.25585318
22Abnormality of endocrine pancreas physiology (HP:0012093)4.25585318
23Amyloidosis (HP:0011034)4.07347383
24Insulin-resistant diabetes mellitus (HP:0000831)3.91420793
25Reduced subcutaneous adipose tissue (HP:0003758)3.81406448
26Protruding tongue (HP:0010808)3.79647371
27Growth hormone excess (HP:0000845)3.78179008
28Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)3.67195258
29Bulbar palsy (HP:0001283)3.27898954
30Abnormality of the dental pulp (HP:0006479)3.22459403
31Abnormality of the dental root (HP:0006486)3.22434158
32Taurodontia (HP:0000679)3.22434158
33Abnormality of permanent molar morphology (HP:0011071)3.22434158
34Facial cleft (HP:0002006)3.20494984
35Abnormality of molar (HP:0011077)3.09598158
36Abnormality of molar morphology (HP:0011070)3.09598158
37Ketoacidosis (HP:0001993)3.09437910
38Hyperglycemia (HP:0003074)2.96993862
39Dysmetric saccades (HP:0000641)2.93001992
40Large hands (HP:0001176)2.90135202
41Abnormality of the incisor (HP:0000676)2.86846379
42Right ventricular cardiomyopathy (HP:0011663)2.84141420
43Insulin resistance (HP:0000855)2.83551742
44Abnormality of the alveolar ridges (HP:0006477)2.83289408
45Impaired smooth pursuit (HP:0007772)2.82034286
46Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.81667797
47Intellectual disability, moderate (HP:0002342)2.79609628
48Clitoromegaly (HP:0000057)2.78229424
49Hepatocellular carcinoma (HP:0001402)2.68429979
50Acanthosis nigricans (HP:0000956)2.67305873
51Synostosis of carpal bones (HP:0005048)2.58502135
52Neoplasm of the liver (HP:0002896)2.54681549
53Diaphragmatic weakness (HP:0009113)2.53936231
54Cubitus valgus (HP:0002967)2.52772308
55Molar tooth sign on MRI (HP:0002419)2.47599223
56Abnormality of midbrain morphology (HP:0002418)2.47599223
57Complete atrioventricular canal defect (HP:0001674)2.46714667
58Spinal rigidity (HP:0003306)2.44840769
59Carpal synostosis (HP:0009702)2.42620353
60Gastrointestinal dysmotility (HP:0002579)2.38317607
61Abnormality of the heme biosynthetic pathway (HP:0010472)2.34882436
62Abnormality of the epiphyses of the hand (HP:0005924)2.33687457
63Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.24011708
64Tachypnea (HP:0002789)2.12344721
65Optic nerve coloboma (HP:0000588)2.11363817
66Portal hypertension (HP:0001409)2.11273725
67Emphysema (HP:0002097)2.06282626
68Abnormality of the antihelix (HP:0009738)2.04702222
69Genetic anticipation (HP:0003743)2.03780113
70Abnormality of saccadic eye movements (HP:0000570)2.00476514
71Synostosis involving bones of the hand (HP:0004278)1.98719801
72Abnormality of the hepatic vasculature (HP:0006707)1.98195422
73Slow saccadic eye movements (HP:0000514)1.96461300
74Self-mutilation (HP:0000742)1.94303928
75Microdontia (HP:0000691)1.94295835
76Postaxial foot polydactyly (HP:0001830)1.93899061
77Bradycardia (HP:0001662)1.92410575
78Abnormality of ocular smooth pursuit (HP:0000617)1.88313843
79Follicular hyperkeratosis (HP:0007502)1.87134422
80Eosinophilia (HP:0001880)1.83613153
81Esophageal neoplasm (HP:0100751)1.82234958
82Neoplasm of head and neck (HP:0012288)1.82234958
83Insomnia (HP:0100785)1.81626401
84Type 1 muscle fiber predominance (HP:0003803)1.81261132
85Slender build (HP:0001533)1.79301658
86Corneal dystrophy (HP:0001131)1.78878767
87Ankle contracture (HP:0006466)1.77126065
88Subacute progressive viral hepatitis (HP:0006572)1.73381044
89Atrioventricular canal defect (HP:0006695)1.73298578
90Retrobulbar optic neuritis (HP:0100654)1.72093856
91Optic neuritis (HP:0100653)1.72093856
92Abnormality of the clitoris (HP:0000056)1.71969258
93Ketosis (HP:0001946)1.71627896
94Orchitis (HP:0100796)1.70632058
95Pulmonary artery stenosis (HP:0004415)1.65782104
96Cervical subluxation (HP:0003308)1.61185568
97Ventricular tachycardia (HP:0004756)1.56869391
98Short tibia (HP:0005736)1.47004597
99Hyperpituitarism (HP:0010514)1.46249914
100Nausea (HP:0002018)1.45638501

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRPM74.46743966
2MAP2K72.60263232
3PINK12.53788259
4EPHA32.19895624
5INSRR14.1312752
6PDGFRA1.92289099
7FLT31.78109106
8NTRK11.70181019
9MAP3K51.66184766
10ZAK1.63615127
11CSK1.37478179
12CCNB11.35642416
13MAP3K41.33381289
14EPHB11.31420096
15MET1.30269162
16TNK21.19170211
17PRPF4B1.01894499
18FGFR41.01850247
19NLK0.94878471
20DYRK20.94394407
21TYK20.89705992
22JAK30.85055465
23JAK10.76138072
24BMPR20.75988637
25ERBB30.73235891
26TXK0.69790063
27MAP2K40.65900645
28MAP3K140.64200815
29CASK0.61671800
30STK240.59380205
31BCR0.58304606
32MOS0.57323409
33FER0.55349103
34STK38L0.53365891
35PRKCH0.53010737
36MAPK130.52911835
37PDGFRB0.48032375
38TAOK30.45595179
39ZAP700.42383843
40IRAK10.41861905
41VRK10.39882674
42EIF2AK30.39103342
43MAP2K20.37335704
44NTRK30.36905089
45PLK20.35975459
46EPHB20.35629052
47IGF1R0.34197560
48SGK20.33284636
49LATS20.30819763
50TGFBR20.29936881
51LYN0.29577828
52RET0.29548250
53IKBKB0.29227804
54MAP3K130.29128465
55PRKCE0.26672175
56MAP3K120.24875478
57TNIK0.24596429
58TIE10.24260405
59PAK60.23862928
60HIPK20.23772881
61PLK40.23754951
62EIF2AK10.23739230
63CAMKK20.23729933
64CAMK1G0.21676480
65SGK4940.21448386
66SGK2230.21448386
67GRK10.21293868
68IRAK30.19982759
69MAP3K10.19276811
70LCK0.18861851
71EIF2AK20.18581353
72TAOK20.18437609
73PKN10.18008196
74MAPK30.17186176
75INSR0.17019899
76SGK30.16822687
77RIPK40.16588282
78ALK0.16110244
79FGFR30.15375039
80SRC0.15190863
81MAPK40.14145030
82MAPK100.13902257
83MAPKAPK20.13896574
84PTK20.12572120
85MAPK120.12044404
86JAK20.10249840
87MAPK90.09887473
88PRKACA0.09610704
89CHUK0.09232410
90PRKCD0.08764628
91MAPK150.08600204
92DAPK20.08239612
93PAK20.08176272
94MAPK140.07211934
95SYK0.06975394
96HCK0.06729884
97NEK60.06604585
98CAMK2D0.06490130
99YES10.05841688
100MAP3K30.05830891

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.39853746
2Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005343.37501316
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.26184117
4Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049603.16470464
5Ovarian steroidogenesis_Homo sapiens_hsa049132.75444319
6Sulfur metabolism_Homo sapiens_hsa009202.64919862
7Vitamin B6 metabolism_Homo sapiens_hsa007502.57987465
8Type II diabetes mellitus_Homo sapiens_hsa049302.41281023
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.01741780
10Tryptophan metabolism_Homo sapiens_hsa003801.92780157
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.82435758
12Thyroid hormone synthesis_Homo sapiens_hsa049181.66602360
13Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.52119038
14Allograft rejection_Homo sapiens_hsa053301.51564357
15Graft-versus-host disease_Homo sapiens_hsa053321.51437484
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.45324634
17Mineral absorption_Homo sapiens_hsa049781.40332446
18Lysine degradation_Homo sapiens_hsa003101.30766693
19Adherens junction_Homo sapiens_hsa045201.24493186
20Arachidonic acid metabolism_Homo sapiens_hsa005901.24435850
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23007547
22Autoimmune thyroid disease_Homo sapiens_hsa053201.22657625
23Apoptosis_Homo sapiens_hsa042101.22390698
24Focal adhesion_Homo sapiens_hsa045101.20342369
25TNF signaling pathway_Homo sapiens_hsa046681.15711015
26Taste transduction_Homo sapiens_hsa047421.13138147
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12188411
28Phospholipase D signaling pathway_Homo sapiens_hsa040721.08987561
29Type I diabetes mellitus_Homo sapiens_hsa049401.08102642
30Glutathione metabolism_Homo sapiens_hsa004801.05867269
31Steroid biosynthesis_Homo sapiens_hsa001001.05047288
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03711600
33Ras signaling pathway_Homo sapiens_hsa040141.02957463
34Herpes simplex infection_Homo sapiens_hsa051681.02565853
35Tyrosine metabolism_Homo sapiens_hsa003500.99936495
36NF-kappa B signaling pathway_Homo sapiens_hsa040640.98070689
37ECM-receptor interaction_Homo sapiens_hsa045120.96170814
38Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92859979
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89950344
40Jak-STAT signaling pathway_Homo sapiens_hsa046300.89478799
41Toxoplasmosis_Homo sapiens_hsa051450.85660578
42Other glycan degradation_Homo sapiens_hsa005110.82504067
43Rheumatoid arthritis_Homo sapiens_hsa053230.81352994
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79692800
45Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76575933
46Insulin resistance_Homo sapiens_hsa049310.75711647
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75642173
48Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73720211
49FoxO signaling pathway_Homo sapiens_hsa040680.72995647
50Prolactin signaling pathway_Homo sapiens_hsa049170.72609396
51Retinol metabolism_Homo sapiens_hsa008300.71908852
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71545393
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.70599108
54Measles_Homo sapiens_hsa051620.68547420
55Prostate cancer_Homo sapiens_hsa052150.67608015
56Chemical carcinogenesis_Homo sapiens_hsa052040.66858631
57Viral myocarditis_Homo sapiens_hsa054160.66656341
58Morphine addiction_Homo sapiens_hsa050320.66011986
59Complement and coagulation cascades_Homo sapiens_hsa046100.65691637
60Cocaine addiction_Homo sapiens_hsa050300.62573172
61Inositol phosphate metabolism_Homo sapiens_hsa005620.61266533
62Legionellosis_Homo sapiens_hsa051340.60445611
63Glioma_Homo sapiens_hsa052140.59970195
64Amoebiasis_Homo sapiens_hsa051460.58813052
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57344707
66Hepatitis B_Homo sapiens_hsa051610.57204505
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56111704
68Histidine metabolism_Homo sapiens_hsa003400.55105747
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52699732
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.52501966
71PPAR signaling pathway_Homo sapiens_hsa033200.51907020
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50461664
73Protein digestion and absorption_Homo sapiens_hsa049740.49568342
74Chemokine signaling pathway_Homo sapiens_hsa040620.48942214
75MAPK signaling pathway_Homo sapiens_hsa040100.48909552
76Amphetamine addiction_Homo sapiens_hsa050310.47796986
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47681212
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46916935
79Pertussis_Homo sapiens_hsa051330.46858810
80African trypanosomiasis_Homo sapiens_hsa051430.46852149
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45588217
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44949595
83TGF-beta signaling pathway_Homo sapiens_hsa043500.44404348
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43359425
85Osteoclast differentiation_Homo sapiens_hsa043800.42577546
86Proteoglycans in cancer_Homo sapiens_hsa052050.42423904
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41674475
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41004873
89HIF-1 signaling pathway_Homo sapiens_hsa040660.39199085
90Phenylalanine metabolism_Homo sapiens_hsa003600.38779459
91Renin-angiotensin system_Homo sapiens_hsa046140.38656522
92Rap1 signaling pathway_Homo sapiens_hsa040150.38557613
93Dilated cardiomyopathy_Homo sapiens_hsa054140.38037729
94beta-Alanine metabolism_Homo sapiens_hsa004100.37777394
95Choline metabolism in cancer_Homo sapiens_hsa052310.37182861
96Olfactory transduction_Homo sapiens_hsa047400.37131696
97Hepatitis C_Homo sapiens_hsa051600.35760572
98Small cell lung cancer_Homo sapiens_hsa052220.35576328
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35196934
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33969526

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