GPHN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.99067501
2L-phenylalanine catabolic process (GO:0006559)4.99067501
3L-phenylalanine metabolic process (GO:0006558)4.49817483
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.49817483
5aromatic amino acid family catabolic process (GO:0009074)4.33522255
6establishment of mitochondrion localization (GO:0051654)3.96893149
7indole-containing compound catabolic process (GO:0042436)3.79497027
8indolalkylamine catabolic process (GO:0046218)3.79497027
9tryptophan catabolic process (GO:0006569)3.79497027
10cellular ketone body metabolic process (GO:0046950)3.79113538
11bile acid biosynthetic process (GO:0006699)3.72635833
12postsynaptic membrane organization (GO:0001941)3.68671372
13dendritic spine morphogenesis (GO:0060997)3.66967719
14neuron recognition (GO:0008038)3.65362366
15axonal fasciculation (GO:0007413)3.61860797
16kynurenine metabolic process (GO:0070189)3.56218637
17tryptophan metabolic process (GO:0006568)3.53492778
18urea metabolic process (GO:0019627)3.52436030
19urea cycle (GO:0000050)3.52436030
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.48635793
21auditory behavior (GO:0031223)3.43469546
22alpha-linolenic acid metabolic process (GO:0036109)3.38965341
23pyrimidine nucleobase catabolic process (GO:0006208)3.38678545
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.36097746
25regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.35709470
26coenzyme catabolic process (GO:0009109)3.35617889
27glutamate metabolic process (GO:0006536)3.35430618
28glyoxylate metabolic process (GO:0046487)3.33470511
29righting reflex (GO:0060013)3.32966561
30behavioral response to nicotine (GO:0035095)3.29597089
31ketone body metabolic process (GO:1902224)3.28852281
32mitochondrion transport along microtubule (GO:0047497)3.24961334
33establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.24961334
34neuron cell-cell adhesion (GO:0007158)3.24518136
35vocalization behavior (GO:0071625)3.23376748
36regulation of short-term neuronal synaptic plasticity (GO:0048172)3.23212243
37* neurotransmitter-gated ion channel clustering (GO:0072578)3.20394026
38cysteine metabolic process (GO:0006534)3.20035072
39nitrogen cycle metabolic process (GO:0071941)3.19508132
40synapse assembly (GO:0007416)3.18387330
41gamma-aminobutyric acid transport (GO:0015812)3.18323463
42high-density lipoprotein particle remodeling (GO:0034375)3.17411248
43dicarboxylic acid biosynthetic process (GO:0043650)3.16338333
44positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.15915196
45bile acid metabolic process (GO:0008206)3.14196503
46synaptic vesicle exocytosis (GO:0016079)3.06971250
47nucleobase catabolic process (GO:0046113)3.05800905
48negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05496220
49central nervous system projection neuron axonogenesis (GO:0021952)3.04855079
50startle response (GO:0001964)3.01984575
51aromatic amino acid family metabolic process (GO:0009072)3.01181351
52tyrosine metabolic process (GO:0006570)3.00874961
53alpha-amino acid catabolic process (GO:1901606)2.93387348
54synaptic vesicle docking involved in exocytosis (GO:0016081)2.93325530
55complement activation, alternative pathway (GO:0006957)2.91302282
56regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.90088039
57negative regulation of cytosolic calcium ion concentration (GO:0051481)2.89328252
58mechanosensory behavior (GO:0007638)2.89306801
59regulation of bile acid biosynthetic process (GO:0070857)2.88659934
60glutamate secretion (GO:0014047)2.87353375
61regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.86856403
62presynaptic membrane assembly (GO:0097105)2.86431636
63neuromuscular synaptic transmission (GO:0007274)2.86108712
64behavioral response to cocaine (GO:0048148)2.85986397
65neuronal ion channel clustering (GO:0045161)2.85473561
66ionotropic glutamate receptor signaling pathway (GO:0035235)2.83728240
67regulation of fibrinolysis (GO:0051917)2.81973894
68peptidyl-glutamic acid carboxylation (GO:0017187)2.81943279
69protein carboxylation (GO:0018214)2.81943279
70short-chain fatty acid metabolic process (GO:0046459)2.81887239
71macromolecular complex remodeling (GO:0034367)2.81820226
72plasma lipoprotein particle remodeling (GO:0034369)2.81820226
73protein-lipid complex remodeling (GO:0034368)2.81820226
74neurotransmitter secretion (GO:0007269)2.81562367
75C4-dicarboxylate transport (GO:0015740)2.81316177
76glutamate receptor signaling pathway (GO:0007215)2.81102988
77drug catabolic process (GO:0042737)2.80230218
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.79667422
79regulation of dendritic spine morphogenesis (GO:0061001)2.79504670
80regulation of protein activation cascade (GO:2000257)2.79176489
81indolalkylamine metabolic process (GO:0006586)2.78965115
82lysine catabolic process (GO:0006554)2.78902533
83lysine metabolic process (GO:0006553)2.78902533
84sulfur amino acid catabolic process (GO:0000098)2.77983794
85dicarboxylic acid catabolic process (GO:0043649)2.77896642
86transmission of nerve impulse (GO:0019226)2.77071919
87cellular amino acid catabolic process (GO:0009063)2.75945056
88reverse cholesterol transport (GO:0043691)2.75921923
89presynaptic membrane organization (GO:0097090)2.75368885
90negative regulation of fibrinolysis (GO:0051918)2.74902431
91regulation of glutamate receptor signaling pathway (GO:1900449)2.74377083
92positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.73349595
93positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.72879490
94cellular modified amino acid catabolic process (GO:0042219)2.72462215
95retinal ganglion cell axon guidance (GO:0031290)2.71087351
96protein localization to synapse (GO:0035418)2.70827533
97response to auditory stimulus (GO:0010996)2.69625400
98amine catabolic process (GO:0009310)2.69394910
99cellular biogenic amine catabolic process (GO:0042402)2.69394910
100regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.69070459
101low-density lipoprotein particle remodeling (GO:0034374)2.68953702
102cerebellar granule cell differentiation (GO:0021707)2.68680522
103regulation of cholesterol esterification (GO:0010872)2.68375428
104homocysteine metabolic process (GO:0050667)2.67176047
105regulation of synaptic vesicle exocytosis (GO:2000300)2.67107967
106locomotory exploration behavior (GO:0035641)2.66954942
107neuron-neuron synaptic transmission (GO:0007270)2.66582826
108regulation of neurotransmitter levels (GO:0001505)2.66549891
109negative regulation of synaptic transmission, GABAergic (GO:0032229)2.66391193
110positive regulation of dendritic spine morphogenesis (GO:0061003)2.66137139
111fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.64864674
112acylglycerol homeostasis (GO:0055090)2.63363121
113triglyceride homeostasis (GO:0070328)2.63363121
114exogenous drug catabolic process (GO:0042738)2.63330426
115limb bud formation (GO:0060174)2.63097609
116membrane depolarization during action potential (GO:0086010)2.62532759
117regulation of synapse structural plasticity (GO:0051823)2.61705101
118behavioral response to ethanol (GO:0048149)2.61682290
119serine family amino acid catabolic process (GO:0009071)2.61072736
120fatty acid elongation (GO:0030497)2.59013552
121regulation of female receptivity (GO:0045924)2.58296338
122nonmotile primary cilium assembly (GO:0035058)2.57825290
123regulation of complement activation (GO:0030449)2.57547010
124cell migration in hindbrain (GO:0021535)2.56837660
125acetyl-CoA metabolic process (GO:0006084)2.56349166
126synaptic transmission, glutamatergic (GO:0035249)2.56281423
127succinate metabolic process (GO:0006105)2.55545793
128regulation of triglyceride catabolic process (GO:0010896)2.54660965
129female mating behavior (GO:0060180)2.54548867
130indole-containing compound metabolic process (GO:0042430)2.53902811
131protein polyglutamylation (GO:0018095)2.53279557
132dendrite morphogenesis (GO:0048813)2.53205397
133positive regulation of synapse assembly (GO:0051965)2.52964170
134cholesterol efflux (GO:0033344)2.52759007
135synaptic vesicle maturation (GO:0016188)2.52029575
136cofactor catabolic process (GO:0051187)2.51294320
137aspartate family amino acid catabolic process (GO:0009068)2.51254415
138central nervous system neuron axonogenesis (GO:0021955)2.51229531
139regulation of respiratory system process (GO:0044065)2.50314521
140neuronal action potential propagation (GO:0019227)2.49957653
141very long-chain fatty acid metabolic process (GO:0000038)2.49599447
142benzene-containing compound metabolic process (GO:0042537)2.48740187
143* synapse organization (GO:0050808)2.48709906
144synaptic vesicle endocytosis (GO:0048488)2.47151020
145neurotransmitter transport (GO:0006836)2.46340798
146dendritic spine organization (GO:0097061)2.46210405
147negative regulation of dendrite development (GO:2000171)2.45252127
148reflex (GO:0060004)2.45051712
149regulation of synaptic transmission, glutamatergic (GO:0051966)2.43535494
150adult walking behavior (GO:0007628)2.41957846
151positive regulation of mitochondrial fission (GO:0090141)2.41779035
152water-soluble vitamin biosynthetic process (GO:0042364)2.40990643
153proline transport (GO:0015824)2.40454454
154hippocampus development (GO:0021766)2.39963489
155calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.39505728
156regulation of synaptic vesicle transport (GO:1902803)2.34189009
157adult behavior (GO:0030534)2.33886958
158central nervous system myelination (GO:0022010)2.33744356
159axon ensheathment in central nervous system (GO:0032291)2.33744356
160cerebral cortex radially oriented cell migration (GO:0021799)2.31391615
161behavioral defense response (GO:0002209)2.29556086
162behavioral fear response (GO:0001662)2.29556086
163regulation of synapse assembly (GO:0051963)2.28403178
164sympathetic nervous system development (GO:0048485)2.28322345
165synaptic transmission, cholinergic (GO:0007271)2.27181686
166regulation of postsynaptic membrane potential (GO:0060078)2.26612039
167neurotransmitter catabolic process (GO:0042135)2.24464693
168exploration behavior (GO:0035640)2.23713806
169regulation of collateral sprouting (GO:0048670)2.23561100
170synaptic transmission (GO:0007268)2.23428466
171negative regulation of axon extension (GO:0030517)2.22365386

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.64898722
2EZH2_22144423_ChIP-Seq_EOC_Human3.57709553
3* GBX2_23144817_ChIP-Seq_PC3_Human3.40420962
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.64985032
5TAF15_26573619_Chip-Seq_HEK293_Human2.46071174
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.43050757
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.36687047
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36015011
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.23444281
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.23286638
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.11111201
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.07571727
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00637036
14PPARA_22158963_ChIP-Seq_LIVER_Mouse1.99069705
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98090584
16MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94499499
17* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94262060
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.92184275
19* REST_21632747_ChIP-Seq_MESCs_Mouse1.91075351
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89542078
21RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89542078
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89541590
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.86528677
24* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79903221
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78923442
26* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77536573
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77269350
28AR_21572438_ChIP-Seq_LNCaP_Human1.76689780
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.76238938
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.75313225
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75010685
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.72922729
33RNF2_27304074_Chip-Seq_NSC_Mouse1.70980774
34P300_19829295_ChIP-Seq_ESCs_Human1.61754586
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.60794799
36* SMAD4_21799915_ChIP-Seq_A2780_Human1.59974702
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.59094509
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58650328
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58559247
40DROSHA_22980978_ChIP-Seq_HELA_Human1.58521618
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.55304180
42* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54409084
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53406584
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.53236350
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52166121
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49497837
47EWS_26573619_Chip-Seq_HEK293_Human1.47603693
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45624839
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.45601436
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45286223
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45170182
52* RARB_27405468_Chip-Seq_BRAIN_Mouse1.44492830
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43720169
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38559210
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37002656
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34859257
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31815712
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.31607562
59AR_25329375_ChIP-Seq_VCAP_Human1.28905682
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.24236700
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23082568
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21903173
63* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21574104
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21349402
65RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21293536
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21060423
67* STAT3_23295773_ChIP-Seq_U87_Human1.19521264
68* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19070272
69* SOX9_26525672_Chip-Seq_HEART_Mouse1.18883767
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18301805
71TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17249612
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16402456
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.15261520
74TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15021265
75IRF1_19129219_ChIP-ChIP_H3396_Human1.14840155
76HTT_18923047_ChIP-ChIP_STHdh_Human1.14712312
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14159117
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.12775270
79* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12596756
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10785909
81BCAT_22108803_ChIP-Seq_LS180_Human1.10016838
82IGF1R_20145208_ChIP-Seq_DFB_Human1.07432655
83* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07168170
84NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06824148
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06824148
86AHR_22903824_ChIP-Seq_MCF-7_Human1.06625529
87* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06533660
88KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06283564
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04734671
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04682021
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04682021
92* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03801073
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03026454
94RUNX2_22187159_ChIP-Seq_PCA_Human1.02084124
95* TCF4_23295773_ChIP-Seq_U87_Human1.01936922
96ZNF274_21170338_ChIP-Seq_K562_Hela1.01863523
97* ER_23166858_ChIP-Seq_MCF-7_Human1.01403331
98FUS_26573619_Chip-Seq_HEK293_Human1.01373356
99TAL1_26923725_Chip-Seq_HPCs_Mouse1.00642872
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.00156810
101ERG_21242973_ChIP-ChIP_JURKAT_Human0.99914021
102* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99525950
103TP53_22573176_ChIP-Seq_HFKS_Human0.98683615
104FOXA2_19822575_ChIP-Seq_HepG2_Human0.98456634
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98084844
106* AR_19668381_ChIP-Seq_PC3_Human0.97065755
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96814473
108* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96727701
109MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96004187
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95641961
111KDM2B_26808549_Chip-Seq_REH_Human0.95545330
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95365463
113CBP_20019798_ChIP-Seq_JUKART_Human0.95312083
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95312083
115* RING1B_27294783_Chip-Seq_ESCs_Mouse0.94922507
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94832682
117TP53_18474530_ChIP-ChIP_U2OS_Human0.93108839
118CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93053787
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92679735
120PRDM14_20953172_ChIP-Seq_ESCs_Human0.92355660
121FLI1_27457419_Chip-Seq_LIVER_Mouse0.92100185
122VDR_22108803_ChIP-Seq_LS180_Human0.91630299
123MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90910268
124* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90363080
125SMAD4_21741376_ChIP-Seq_HESCs_Human0.89096805
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89016812
127TCF4_22108803_ChIP-Seq_LS180_Human0.87472216

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.85092612
2MP0005360_urolithiasis4.63909695
3MP0005085_abnormal_gallbladder_physiolo3.72967644
4MP0005365_abnormal_bile_salt3.57246164
5MP0004859_abnormal_synaptic_plasticity3.35791115
6MP0003880_abnormal_central_pattern3.30396844
7MP0008875_abnormal_xenobiotic_pharmacok3.23044965
8MP0002822_catalepsy2.96938391
9MP0003635_abnormal_synaptic_transmissio2.62786593
10MP0004270_analgesia2.48306454
11MP0009745_abnormal_behavioral_response2.41930843
12MP0002063_abnormal_learning/memory/cond2.23087050
13MP0002064_seizures2.20612237
14MP0010329_abnormal_lipoprotein_level2.15864326
15MP0009046_muscle_twitch2.12866256
16MP0002572_abnormal_emotion/affect_behav1.98809794
17MP0003252_abnormal_bile_duct1.98133125
18MP0003122_maternal_imprinting1.96386777
19MP0003329_amyloid_beta_deposits1.95135538
20MP0001486_abnormal_startle_reflex1.90888806
21MP0003195_calcinosis1.90845671
22* MP0002272_abnormal_nervous_system1.89947064
23MP0003787_abnormal_imprinting1.89689060
24MP0001501_abnormal_sleep_pattern1.88159392
25MP0009780_abnormal_chondrocyte_physiolo1.82910608
26MP0005332_abnormal_amino_acid1.80306434
27MP0001984_abnormal_olfaction1.76339233
28MP0005423_abnormal_somatic_nervous1.72317374
29MP0002102_abnormal_ear_morphology1.71149366
30MP0001968_abnormal_touch/_nociception1.68691180
31MP0001440_abnormal_grooming_behavior1.68599111
32MP0002876_abnormal_thyroid_physiology1.68062675
33MP0002734_abnormal_mechanical_nocicepti1.64840083
34MP0005187_abnormal_penis_morphology1.64244047
35MP0000566_synostosis1.62038675
36MP0005646_abnormal_pituitary_gland1.58147605
37MP0003690_abnormal_glial_cell1.55672038
38MP0003806_abnormal_nucleotide_metabolis1.53253744
39MP0002837_dystrophic_cardiac_calcinosis1.53217322
40MP0005083_abnormal_biliary_tract1.52120079
41MP0000631_abnormal_neuroendocrine_gland1.44633810
42MP0001188_hyperpigmentation1.43083725
43MP0005394_taste/olfaction_phenotype1.42893007
44MP0005499_abnormal_olfactory_system1.42893007
45MP0001502_abnormal_circadian_rhythm1.40344399
46MP0003121_genomic_imprinting1.40172155
47MP0002118_abnormal_lipid_homeostasis1.39464589
48MP0001666_abnormal_nutrient_absorption1.39339199
49MP0000604_amyloidosis1.37454895
50* MP0002067_abnormal_sensory_capabilities1.37215255
51MP0006276_abnormal_autonomic_nervous1.36317672
52MP0005551_abnormal_eye_electrophysiolog1.36212778
53MP0005535_abnormal_body_temperature1.33425402
54MP0002735_abnormal_chemical_nociception1.32692792
55MP0004142_abnormal_muscle_tone1.30666622
56MP0003868_abnormal_feces_composition1.30362656
57MP0000778_abnormal_nervous_system1.30302019
58MP0002736_abnormal_nociception_after1.30031337
59MP0004145_abnormal_muscle_electrophysio1.27032329
60MP0002751_abnormal_autonomic_nervous1.25512375
61MP0002234_abnormal_pharynx_morphology1.24383312
62* MP0005386_behavior/neurological_phenoty1.23493081
63* MP0004924_abnormal_behavior1.23493081
64MP0002733_abnormal_thermal_nociception1.20052392
65MP0002557_abnormal_social/conspecific_i1.19735597
66MP0002184_abnormal_innervation1.13536592
67MP0004019_abnormal_vitamin_homeostasis1.12686468
68MP0004043_abnormal_pH_regulation1.12523066
69MP0003633_abnormal_nervous_system1.10008612
70MP0002638_abnormal_pupillary_reflex1.09516636
71MP0005584_abnormal_enzyme/coenzyme_acti1.09296285
72MP0001970_abnormal_pain_threshold1.08555299
73MP0008789_abnormal_olfactory_epithelium1.08185420
74MP0004885_abnormal_endolymph1.07119252
75MP0002152_abnormal_brain_morphology1.06679337
76MP0001905_abnormal_dopamine_level1.06107763
77MP0008569_lethality_at_weaning1.05600741
78MP0003879_abnormal_hair_cell1.05358944
79MP0004133_heterotaxia1.04508461
80MP0008877_abnormal_DNA_methylation1.04134322
81MP0005253_abnormal_eye_physiology1.03889529
82MP0005645_abnormal_hypothalamus_physiol1.03691882
83MP0002090_abnormal_vision1.02062269
84* MP0002752_abnormal_somatic_nervous1.00965882
85MP0002138_abnormal_hepatobiliary_system1.00745192
86MP0002653_abnormal_ependyma_morphology1.00542745
87MP0006072_abnormal_retinal_apoptosis1.00283197
88MP0004130_abnormal_muscle_cell0.99155985
89* MP0002066_abnormal_motor_capabilities/c0.98363732
90MP0002938_white_spotting0.97842663
91MP0000569_abnormal_digit_pigmentation0.96717226
92MP0001346_abnormal_lacrimal_gland0.96692968
93MP0003631_nervous_system_phenotype0.94995730
94MP0006292_abnormal_olfactory_placode0.94567605
95* MP0001529_abnormal_vocalization0.94350447
96MP0009697_abnormal_copulation0.91943817
97MP0000026_abnormal_inner_ear0.91905691
98MP0002909_abnormal_adrenal_gland0.91688953
99MP0001764_abnormal_homeostasis0.91291975
100MP0003119_abnormal_digestive_system0.90791761
101MP0000920_abnormal_myelination0.89454966
102MP0001485_abnormal_pinna_reflex0.89091947
103* MP0003861_abnormal_nervous_system0.88569045
104* MP0002229_neurodegeneration0.88342080
105MP0002928_abnormal_bile_duct0.87033842
106MP0009840_abnormal_foam_cell0.86475361
107* MP0000955_abnormal_spinal_cord0.86231838
108* MP0002069_abnormal_eating/drinking_beha0.85314820
109* MP0002882_abnormal_neuron_morphology0.84590417
110MP0002254_reproductive_system_inflammat0.83925940
111MP0008872_abnormal_physiological_respon0.83190607
112MP0008874_decreased_physiological_sensi0.83138217
113MP0000609_abnormal_liver_physiology0.82915497
114MP0003890_abnormal_embryonic-extraembry0.82323713
115MP0001963_abnormal_hearing_physiology0.81978185
116MP0002078_abnormal_glucose_homeostasis0.81878256
117MP0005319_abnormal_enzyme/_coenzyme0.80602258
118MP0004811_abnormal_neuron_physiology0.79958827
119MP0003283_abnormal_digestive_organ0.78126649
120MP0005670_abnormal_white_adipose0.77324323
121MP0001986_abnormal_taste_sensitivity0.76130455
122MP0003646_muscle_fatigue0.75110544
123MP0003632_abnormal_nervous_system0.74785429
124MP0000647_abnormal_sebaceous_gland0.71254245
125MP0005448_abnormal_energy_balance0.69978309
126MP0001177_atelectasis0.69737563
127MP0003137_abnormal_impulse_conducting0.69465169
128MP0004742_abnormal_vestibular_system0.68410897
129* MP0005195_abnormal_posterior_eye0.67721571
130MP0003075_altered_response_to0.67475827
131MP0004215_abnormal_myocardial_fiber0.66198007
132MP0002971_abnormal_brown_adipose0.66109876
133MP0010386_abnormal_urinary_bladder0.65714946
134MP0005647_abnormal_sex_gland0.65421376
135MP0005451_abnormal_body_composition0.65353954
136MP0002233_abnormal_nose_morphology0.64841926
137MP0003315_abnormal_perineum_morphology0.64812832
138MP0004085_abnormal_heartbeat0.64263076
139MP0003011_delayed_dark_adaptation0.63847134
140MP0002160_abnormal_reproductive_system0.63218485
141MP0003634_abnormal_glial_cell0.62717868
142MP0003191_abnormal_cellular_cholesterol0.62664343
143MP0003183_abnormal_peptide_metabolism0.62487411
144MP0006035_abnormal_mitochondrial_morpho0.61875212

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.89253887
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.73792275
3Intrahepatic cholestasis (HP:0001406)4.52788960
4Deep venous thrombosis (HP:0002625)4.28864008
5Prolonged partial thromboplastin time (HP:0003645)4.08028102
6Hyperventilation (HP:0002883)4.01195949
7Hypobetalipoproteinemia (HP:0003563)3.87980203
8Xanthomatosis (HP:0000991)3.64059613
9Hyperlipoproteinemia (HP:0010980)3.55722282
10Myokymia (HP:0002411)3.48975729
11Abnormality of monocarboxylic acid metabolism (HP:0010996)3.33514169
12Limb dystonia (HP:0002451)3.33195288
13Focal seizures (HP:0007359)3.32909219
14Ketosis (HP:0001946)3.22731722
15Gait imbalance (HP:0002141)3.18355560
16Epidermoid cyst (HP:0200040)3.15779089
17Epileptic encephalopathy (HP:0200134)3.15172312
18Atonic seizures (HP:0010819)3.04855184
19Complement deficiency (HP:0004431)3.03565455
20Ketoacidosis (HP:0001993)2.97609375
21Febrile seizures (HP:0002373)2.93368872
22Absence seizures (HP:0002121)2.85678081
23Conjugated hyperbilirubinemia (HP:0002908)2.81847169
24Hyperglycinemia (HP:0002154)2.79162661
25Neurofibrillary tangles (HP:0002185)2.78128984
26Hyperammonemia (HP:0001987)2.77719062
27Hypolipoproteinemia (HP:0010981)2.75112885
28Generalized tonic-clonic seizures (HP:0002069)2.74660252
29Medial flaring of the eyebrow (HP:0010747)2.69425182
30Congenital primary aphakia (HP:0007707)2.67078544
31Status epilepticus (HP:0002133)2.64560926
32Dialeptic seizures (HP:0011146)2.64397640
33Abnormality of glycine metabolism (HP:0010895)2.55425108
34Abnormality of serine family amino acid metabolism (HP:0010894)2.55425108
35Abnormality of aspartate family amino acid metabolism (HP:0010899)2.52787201
36Nephrogenic diabetes insipidus (HP:0009806)2.51901176
37Joint hemorrhage (HP:0005261)2.51821285
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.51209745
39Progressive cerebellar ataxia (HP:0002073)2.51067941
40Hyperglycinuria (HP:0003108)2.49265947
41Abnormality of glutamine family amino acid metabolism (HP:0010902)2.47883333
42Cerebral inclusion bodies (HP:0100314)2.47520032
43Fat malabsorption (HP:0002630)2.46743869
44Abnormality of methionine metabolism (HP:0010901)2.46380391
45Lissencephaly (HP:0001339)2.45000348
46Abnormality of the common coagulation pathway (HP:0010990)2.42347171
47Abnormality of sulfur amino acid metabolism (HP:0004339)2.42090008
48Pheochromocytoma (HP:0002666)2.40036547
49Renal cortical cysts (HP:0000803)2.39302952
50Abnormality of the labia minora (HP:0012880)2.36296115
51Visual hallucinations (HP:0002367)2.36228137
52Drooling (HP:0002307)2.35648455
53Excessive salivation (HP:0003781)2.35648455
54Abnormal gallbladder physiology (HP:0012438)2.33344111
55Cholecystitis (HP:0001082)2.33344111
56Blue irides (HP:0000635)2.33143234
57Hemiparesis (HP:0001269)2.32751722
58Nephronophthisis (HP:0000090)2.32329990
59Gout (HP:0001997)2.31749374
60Cerebral edema (HP:0002181)2.29507099
61Epileptiform EEG discharges (HP:0011182)2.27320678
62Hypoalphalipoproteinemia (HP:0003233)2.27107658
63Pancreatic cysts (HP:0001737)2.23381025
64Retinal dysplasia (HP:0007973)2.22930514
65Specific learning disability (HP:0001328)2.22019680
66Vaginal atresia (HP:0000148)2.20944945
67Exercise-induced myalgia (HP:0003738)2.20546019
68Pachygyria (HP:0001302)2.19428003
69EEG with generalized epileptiform discharges (HP:0011198)2.19010587
70Dysdiadochokinesis (HP:0002075)2.18752625
71Torticollis (HP:0000473)2.18032264
72Genital tract atresia (HP:0001827)2.14948834
73Abnormality of the corticospinal tract (HP:0002492)2.14241888
74Action tremor (HP:0002345)2.12946590
75Abnormal gallbladder morphology (HP:0012437)2.12228658
76Dysmetria (HP:0001310)2.11128799
77True hermaphroditism (HP:0010459)2.10945543
78Sensorimotor neuropathy (HP:0007141)2.10330371
79Hypercholesterolemia (HP:0003124)2.09595801
80Hypsarrhythmia (HP:0002521)2.09298418
81Urinary urgency (HP:0000012)2.08946336
82Fair hair (HP:0002286)2.07836413
83Neuroendocrine neoplasm (HP:0100634)2.07733365
84Metabolic acidosis (HP:0001942)2.07600777
85Poor suck (HP:0002033)2.07146619
86Impaired vibration sensation in the lower limbs (HP:0002166)2.06047924
87Acute encephalopathy (HP:0006846)2.05568964
88Anxiety (HP:0000739)2.05208424
89Type II lissencephaly (HP:0007260)2.04207233
90Cortical dysplasia (HP:0002539)2.03465124
91Cholelithiasis (HP:0001081)2.03306116
92Craniofacial dystonia (HP:0012179)2.03276066
93Focal dystonia (HP:0004373)2.03272189
94Spontaneous abortion (HP:0005268)2.02852059
95Skin nodule (HP:0200036)2.01675349
96Scanning speech (HP:0002168)2.01172329
97Impaired social interactions (HP:0000735)2.00451496
98Abnormal social behavior (HP:0012433)2.00451496
99Acute necrotizing encephalopathy (HP:0006965)1.99439319
100Spastic gait (HP:0002064)1.99260050
101Oligodactyly (hands) (HP:0001180)1.98389346
102Abnormal eating behavior (HP:0100738)1.97751117
103Methylmalonic acidemia (HP:0002912)1.97328377
104Broad-based gait (HP:0002136)1.97066084
105Spastic tetraplegia (HP:0002510)1.96578595
106Poor coordination (HP:0002370)1.92824342
107Lethargy (HP:0001254)1.92478058
108Muscular hypotonia of the trunk (HP:0008936)1.90745235
109Abnormality of purine metabolism (HP:0004352)1.90300789
110Abnormality of the renal medulla (HP:0100957)1.90209165
111Delayed CNS myelination (HP:0002188)1.90068552
112Pancreatic fibrosis (HP:0100732)1.88298156
113Absent speech (HP:0001344)1.88106525
114Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.87720966
115Hyperbilirubinemia (HP:0002904)1.87602951
116Supranuclear gaze palsy (HP:0000605)1.87091719
117Abnormality of the renal cortex (HP:0011035)1.87033977
118Poor eye contact (HP:0000817)1.86995695
119Abnormality of serum amino acid levels (HP:0003112)1.86984592
120Tubulointerstitial nephritis (HP:0001970)1.85508281
121Abnormality of the intrinsic pathway (HP:0010989)1.84869457
122Polyphagia (HP:0002591)1.84791876
123Intention tremor (HP:0002080)1.84694885
124Abnormality of fatty-acid metabolism (HP:0004359)1.84539738
125Hypoplasia of the brainstem (HP:0002365)1.84440118
126Aplasia/Hypoplasia of the brainstem (HP:0007362)1.84440118
127Generalized myoclonic seizures (HP:0002123)1.83004019
128Inability to walk (HP:0002540)1.82519444
129Hepatocellular necrosis (HP:0001404)1.82510073
130Urinary bladder sphincter dysfunction (HP:0002839)1.82357920
131Hypochromic microcytic anemia (HP:0004840)1.81853325
132Hypoglycemic coma (HP:0001325)1.81552146
133Ankle clonus (HP:0011448)1.81477307
134Morphological abnormality of the pyramidal tract (HP:0002062)1.81104380
135Abnormal mitochondria in muscle tissue (HP:0008316)1.80697089
136Progressive macrocephaly (HP:0004481)1.80681035
137Irritability (HP:0000737)1.80475774
138Optic nerve hypoplasia (HP:0000609)1.80256965
139Degeneration of the lateral corticospinal tracts (HP:0002314)1.79226239
140Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79226239
141Abnormality of the gallbladder (HP:0005264)1.78554794
142Abnormality of midbrain morphology (HP:0002418)1.77072114
143Molar tooth sign on MRI (HP:0002419)1.77072114
144Amblyopia (HP:0000646)1.76479494
145Gaze-evoked nystagmus (HP:0000640)1.75940223
146Failure to thrive in infancy (HP:0001531)1.75599764
147Hepatic necrosis (HP:0002605)1.73522308
148Colon cancer (HP:0003003)1.72969535
149Fetal akinesia sequence (HP:0001989)1.70935892
150Chronic hepatic failure (HP:0100626)1.68033496
151Exotropia (HP:0000577)1.66537885
152Mitochondrial inheritance (HP:0001427)1.64046795
153Renal hypoplasia (HP:0000089)1.63990068
154Hepatoblastoma (HP:0002884)1.63911705
155Agitation (HP:0000713)1.63574436
156Intestinal atresia (HP:0011100)1.63195525
157Anophthalmia (HP:0000528)1.62254083
158Astrocytoma (HP:0009592)1.62034585
159Abnormality of the astrocytes (HP:0100707)1.62034585
160Dyskinesia (HP:0100660)1.61944715
161Hypoplasia of the corpus callosum (HP:0002079)1.61315131
162Amyotrophic lateral sclerosis (HP:0007354)1.57950827
163Hypothermia (HP:0002045)1.54896285
164Increased CSF lactate (HP:0002490)1.54542273

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.11193882
2CASK3.20624002
3NTRK33.19777242
4MARK12.86197971
5MAP3K42.71986025
6MAP2K72.47723070
7MAP2K42.27706932
8MAP4K22.26300591
9DAPK21.90073801
10MINK11.82216113
11TNIK1.81753024
12OXSR11.79015640
13INSRR1.75235690
14NTRK21.67943347
15DYRK21.65798909
16ERBB41.65760780
17SGK4941.54127479
18SGK2231.54127479
19MAP3K91.53430568
20RIPK41.49321419
21BCKDK1.44408702
22PHKG11.43223016
23PHKG21.43223016
24SGK21.36643845
25PRPF4B1.34076902
26TRIM281.32825621
27CCNB11.30958556
28CSNK1G11.29604834
29MAPK131.28624023
30PAK61.28568443
31ERBB31.25974595
32STK391.25220053
33PRKCG1.19539026
34MAP3K121.18172073
35FGFR21.15172678
36CDK51.12927045
37GRK51.12579620
38PKN11.12070495
39KSR11.11836519
40TAOK31.10141691
41SGK31.08556187
42CAMK2A1.07967509
43AKT31.07149745
44CSNK1G21.03731157
45PINK11.02712033
46OBSCN1.02116946
47BCR1.01307106
48NTRK10.99158799
49KSR20.98002370
50PLK20.95918487
51MAP3K60.95002072
52SIK10.92621616
53CAMK2B0.92251218
54SIK20.91790294
55WNK40.90513602
56GRK70.90430541
57WNK30.89685481
58EPHA30.88869338
59PAK30.88514940
60PIK3CA0.87773456
61BMPR20.87395324
62FRK0.85057670
63CDK190.83742291
64MAP3K20.80815083
65CAMK2G0.79929299
66TSSK60.79490734
67CAMK1D0.78276393
68MKNK20.78148518
69PRKCZ0.77471257
70MUSK0.76490366
71CAMK1G0.76307586
72ARAF0.75658288
73EPHB20.75286910
74PRKCE0.75262283
75PDPK10.74207623
76FGFR40.74102832
77VRK10.73913188
78SGK10.72765506
79NME10.72761942
80MAP3K70.72579621
81MAP3K130.72132378
82FGR0.71491286
83BMPR1B0.71317467
84CAMKK10.70338142
85FES0.69843654
86MAPK120.66888771
87PNCK0.66818855
88PRKCH0.66752628
89PRKAA10.66352885
90PDK10.65560036
91STK380.65058139
92CDK140.64889739
93CDK150.64352334
94TYRO30.63379451
95CSNK1G30.63241263
96SIK30.62753003
97RET0.62717455
98DAPK10.62490153
99CAMK2D0.61158678
100ZAK0.60996531
101MAPKAPK50.59530741
102ADRBK20.59446910
103UHMK10.58651426
104LMTK20.57467071
105STK110.57379306
106CAMK40.57256612
107CSNK1A1L0.57159355
108PDK40.57027268
109PDK30.57027268
110CSNK1A10.56796233
111CDK11A0.56437476
112WNK10.56368815
113NEK10.55960578
114GRK10.55342331
115LIMK10.55068214
116DYRK1A0.54512577
117CAMKK20.53992079
118PRKACG0.52269868
119DYRK30.51548237
120MARK20.51396764
121MAPK70.51332783
122CSNK1E0.50965355
123NEK60.50691611
124EPHB10.49827202
125SRPK10.49769980
126CDK180.49277264
127CAMK10.48862973
128PRKACA0.48212916
129PRKD30.47411098
130CSNK1D0.44862587
131MKNK10.44150728
132* RPS6KA30.41894972
133ERBB20.40038479
134PRKCI0.38851214
135PRKDC0.38374837
136PRKG10.36480507
137STK38L0.36396051
138RPS6KB10.34741872

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.20454360
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.05495241
3Nitrogen metabolism_Homo sapiens_hsa009102.92652584
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.36742388
5Arginine biosynthesis_Homo sapiens_hsa002202.36587407
6Butanoate metabolism_Homo sapiens_hsa006502.33616947
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19971600
8Nicotine addiction_Homo sapiens_hsa050332.12718396
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.05257825
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.92507868
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.87005975
12Tryptophan metabolism_Homo sapiens_hsa003801.85976116
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.82413158
14Fatty acid degradation_Homo sapiens_hsa000711.71093399
15Propanoate metabolism_Homo sapiens_hsa006401.68191466
16Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64780339
17* GABAergic synapse_Homo sapiens_hsa047271.56707515
18Fatty acid metabolism_Homo sapiens_hsa012121.56609049
19Synaptic vesicle cycle_Homo sapiens_hsa047211.52117860
20Complement and coagulation cascades_Homo sapiens_hsa046101.51388470
21Peroxisome_Homo sapiens_hsa041461.47332036
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46931207
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45535515
24Parkinsons disease_Homo sapiens_hsa050121.43305839
25Bile secretion_Homo sapiens_hsa049761.42699495
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.41777111
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40619597
28PPAR signaling pathway_Homo sapiens_hsa033201.38368086
29Sulfur metabolism_Homo sapiens_hsa009201.33899688
30Pyruvate metabolism_Homo sapiens_hsa006201.31446252
31Phenylalanine metabolism_Homo sapiens_hsa003601.30303703
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.30276957
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28556680
34Protein export_Homo sapiens_hsa030601.27898731
35Histidine metabolism_Homo sapiens_hsa003401.27775418
36Fatty acid elongation_Homo sapiens_hsa000621.27248259
37Glutamatergic synapse_Homo sapiens_hsa047241.26861058
38beta-Alanine metabolism_Homo sapiens_hsa004101.23994755
39Morphine addiction_Homo sapiens_hsa050321.23658156
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19286883
41Circadian entrainment_Homo sapiens_hsa047131.19264439
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16956826
43Chemical carcinogenesis_Homo sapiens_hsa052041.15368491
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12972448
45Amphetamine addiction_Homo sapiens_hsa050311.03750548
46Olfactory transduction_Homo sapiens_hsa047401.03211848
47Tyrosine metabolism_Homo sapiens_hsa003501.02470937
48Steroid biosynthesis_Homo sapiens_hsa001000.97242564
49Collecting duct acid secretion_Homo sapiens_hsa049660.95967893
50Retinol metabolism_Homo sapiens_hsa008300.95757098
51Fatty acid biosynthesis_Homo sapiens_hsa000610.94306857
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93808155
53Taste transduction_Homo sapiens_hsa047420.93800703
54Dopaminergic synapse_Homo sapiens_hsa047280.92802446
55Huntingtons disease_Homo sapiens_hsa050160.92279105
56Long-term potentiation_Homo sapiens_hsa047200.92037636
57Insulin secretion_Homo sapiens_hsa049110.89930608
58Linoleic acid metabolism_Homo sapiens_hsa005910.88834397
59Salivary secretion_Homo sapiens_hsa049700.88743808
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83865505
61Starch and sucrose metabolism_Homo sapiens_hsa005000.77923897
62Caffeine metabolism_Homo sapiens_hsa002320.77019821
63Oocyte meiosis_Homo sapiens_hsa041140.77018980
64ABC transporters_Homo sapiens_hsa020100.76537944
65Renin secretion_Homo sapiens_hsa049240.75837412
66Serotonergic synapse_Homo sapiens_hsa047260.75258561
67Cocaine addiction_Homo sapiens_hsa050300.74802464
68Cholinergic synapse_Homo sapiens_hsa047250.73128053
69Basal transcription factors_Homo sapiens_hsa030220.69083729
70Carbon metabolism_Homo sapiens_hsa012000.67234468
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66384671
72Staphylococcus aureus infection_Homo sapiens_hsa051500.66260819
73Glycerolipid metabolism_Homo sapiens_hsa005610.66187081
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.65815487
75Long-term depression_Homo sapiens_hsa047300.65619510
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.64711148
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64524158
78Selenocompound metabolism_Homo sapiens_hsa004500.64134377
79Gap junction_Homo sapiens_hsa045400.64083657
80Calcium signaling pathway_Homo sapiens_hsa040200.63297408
81Gastric acid secretion_Homo sapiens_hsa049710.62766336
82RNA polymerase_Homo sapiens_hsa030200.61950398
83Ether lipid metabolism_Homo sapiens_hsa005650.61336687
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.59987704
85Alcoholism_Homo sapiens_hsa050340.59312641
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59194951
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59135120
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59050114
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56481322
90Biosynthesis of amino acids_Homo sapiens_hsa012300.56471427
91Phototransduction_Homo sapiens_hsa047440.56356625
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56161135
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55921867
94Fanconi anemia pathway_Homo sapiens_hsa034600.55626176
95Arginine and proline metabolism_Homo sapiens_hsa003300.54902780
96Oxidative phosphorylation_Homo sapiens_hsa001900.54795632
97Fat digestion and absorption_Homo sapiens_hsa049750.52995631
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50994567
99Metabolic pathways_Homo sapiens_hsa011000.50048267
100Type II diabetes mellitus_Homo sapiens_hsa049300.49673804
101Sulfur relay system_Homo sapiens_hsa041220.49257849
102Hedgehog signaling pathway_Homo sapiens_hsa043400.48999960
103Oxytocin signaling pathway_Homo sapiens_hsa049210.46930959
104Vitamin B6 metabolism_Homo sapiens_hsa007500.46337610
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46132377
106Alzheimers disease_Homo sapiens_hsa050100.45942894
107RNA degradation_Homo sapiens_hsa030180.45000624
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.44969788
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44798342
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43285189
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42817168
112Glucagon signaling pathway_Homo sapiens_hsa049220.42778602
113cAMP signaling pathway_Homo sapiens_hsa040240.41709003
114Prion diseases_Homo sapiens_hsa050200.40336923
115Vitamin digestion and absorption_Homo sapiens_hsa049770.34613357
116Vibrio cholerae infection_Homo sapiens_hsa051100.33154905
117Cardiac muscle contraction_Homo sapiens_hsa042600.32839760
118Axon guidance_Homo sapiens_hsa043600.32696777
119Circadian rhythm_Homo sapiens_hsa047100.30991802
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30505020

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