ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	* glycolytic process (GO:0006096)	5.22426108
2	regulation of translational fidelity (GO:0006450)	4.73266716
3	* gluconeogenesis (GO:0006094)	4.52744051
4	DNA unwinding involved in DNA replication (GO:0006268)	4.43186986
5	COPI coating of Golgi vesicle (GO:0048205)	4.31628701
6	Golgi transport vesicle coating (GO:0048200)	4.31628701
7	* hexose biosynthetic process (GO:0019319)	4.20926156
8	* monosaccharide biosynthetic process (GO:0046364)	4.12308872
9	proline biosynthetic process (GO:0006561)	4.01679670
10	mitotic chromosome condensation (GO:0007076)	3.93050630
11	tricarboxylic acid cycle (GO:0006099)	3.91827797
12	mitotic sister chromatid segregation (GO:0000070)	3.80414444
13	* pyruvate metabolic process (GO:0006090)	3.72534137
14	DNA strand elongation involved in DNA replication (GO:0006271)	3.65558592
15	nuclear pore complex assembly (GO:0051292)	3.64353601
16	pentose-phosphate shunt (GO:0006098)	3.62663328
17	L-serine metabolic process (GO:0006563)	3.57159654
18	NADPH regeneration (GO:0006740)	3.55364161
19	formation of translation preinitiation complex (GO:0001731)	3.53592652
20	DNA strand elongation (GO:0022616)	3.51558761
21	NADH metabolic process (GO:0006734)	3.46146732
22	sister chromatid segregation (GO:0000819)	3.43317874
23	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	3.30830938
24	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.28311572
25	tRNA aminoacylation for protein translation (GO:0006418)	3.25996677
26	4-hydroxyproline metabolic process (GO:0019471)	3.23410203
27	peptidyl-arginine omega-N-methylation (GO:0035247)	3.22676018
28	nucleobase-containing small molecule interconversion (GO:0015949)	3.21821075
29	oxaloacetate metabolic process (GO:0006107)	3.21293438
30	nuclear pore organization (GO:0006999)	3.21110022
31	protein maturation by protein folding (GO:0022417)	3.20333428
32	glucose catabolic process (GO:0006007)	3.20323282
33	fructose metabolic process (GO:0006000)	3.18029796
34	amino acid activation (GO:0043038)	3.13512776
35	tRNA aminoacylation (GO:0043039)	3.13512776
36	IMP biosynthetic process (GO:0006188)	3.12827527
37	DNA replication initiation (GO:0006270)	3.11592761
38	peptidyl-proline hydroxylation (GO:0019511)	3.09871334
39	protein complex localization (GO:0031503)	3.05980921
40	folic acid-containing compound biosynthetic process (GO:0009396)	3.05774793
41	mitotic nuclear envelope disassembly (GO:0007077)	3.05525844
42	regulation of translational elongation (GO:0006448)	3.02341910
43	telomere maintenance via semi-conservative replication (GO:0032201)	3.02061787
44	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.01630452
45	sodium ion export (GO:0071436)	2.98121367
46	regulation of mitotic spindle organization (GO:0060236)	2.94876912
47	synaptic vesicle maturation (GO:0016188)	2.92184171
48	membrane disassembly (GO:0030397)	2.89683276
49	nuclear envelope disassembly (GO:0051081)	2.89683276
50	establishment of integrated proviral latency (GO:0075713)	2.89020575
51	IMP metabolic process (GO:0046040)	2.87420684
52	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.83281685
53	* glucose 6-phosphate metabolic process (GO:0051156)	2.81150634
54	proline metabolic process (GO:0006560)	2.80926309
55	regulation of coenzyme metabolic process (GO:0051196)	2.77808561
56	regulation of cofactor metabolic process (GO:0051193)	2.77808561
57	glutamate secretion (GO:0014047)	2.75984793
58	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.73390434
59	pore complex assembly (GO:0046931)	2.72591530
60	nucleobase biosynthetic process (GO:0046112)	2.71247953
61	protein retention in ER lumen (GO:0006621)	2.70091573
62	protein hydroxylation (GO:0018126)	2.69460683
63	melanin biosynthetic process (GO:0042438)	2.68032500
64	peptidyl-arginine methylation (GO:0018216)	2.67862895
65	peptidyl-arginine N-methylation (GO:0035246)	2.67862895
66	positive regulation of DNA-dependent DNA replication (GO:2000105)	2.66787641
67	mitotic nuclear envelope reassembly (GO:0007084)	2.65518646
68	nuclear envelope reassembly (GO:0031468)	2.65518646
69	purine nucleobase biosynthetic process (GO:0009113)	2.64402684
70	histone arginine methylation (GO:0034969)	2.61896782
71	serine family amino acid biosynthetic process (GO:0009070)	2.61380418
72	pteridine-containing compound biosynthetic process (GO:0042559)	2.58032734
73	glutamine metabolic process (GO:0006541)	2.56831878
74	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.55817162
75	chromosome condensation (GO:0030261)	2.54241957
76	cellular protein complex localization (GO:0034629)	2.53515023
77	regulation of spindle organization (GO:0090224)	2.52831701
78	regulation of translational termination (GO:0006449)	2.52825675
79	protein export from nucleus (GO:0006611)	2.50559888
80	nuclear envelope organization (GO:0006998)	2.50531940
81	tetrahydrofolate metabolic process (GO:0046653)	2.48209820
82	mitochondrial fragmentation involved in apoptotic process (GO:0043653)	2.45035014
83	* glucose metabolic process (GO:0006006)	2.44993720
84	regulation of mammary gland epithelial cell proliferation (GO:0033599)	2.44754679
85	oxidative phosphorylation (GO:0006119)	2.44599658
86	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.43880261
87	mitotic sister chromatid cohesion (GO:0007064)	2.43667087
88	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	2.42928641
89	ribosome assembly (GO:0042255)	2.40960368
90	tricarboxylic acid metabolic process (GO:0072350)	2.40320515
91	synaptic vesicle exocytosis (GO:0016079)	2.38646394
92	* single-organism carbohydrate catabolic process (GO:0044724)	2.38380737
93	DNA replication checkpoint (GO:0000076)	2.36966773
94	negative regulation of microtubule polymerization (GO:0031115)	2.36375565
95	layer formation in cerebral cortex (GO:0021819)	2.36065864
96	biotin metabolic process (GO:0006768)	2.35563210
97	negative regulation of cell size (GO:0045792)	2.34731244
98	melanin metabolic process (GO:0006582)	2.34365681
99	DNA duplex unwinding (GO:0032508)	2.32414117
100	mitotic G1 DNA damage checkpoint (GO:0031571)	2.31985335

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.18538932
2	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.73064184
3	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.41698514
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.23414696
5	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.13160209
6	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.48994275
7	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.48801804
8	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.46569526
9	ZNF263_19887448_ChIP-Seq_K562_Human	2.38989185
10	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.38696032
11	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.36069038
12	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.28812464
13	* HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.27003096
14	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.21770522
15	AR_21909140_ChIP-Seq_LNCAP_Human	2.21462091
16	XRN2_22483619_ChIP-Seq_HELA_Human	2.21296804
17	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.13868772
18	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.12393488
19	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	2.11754230
20	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	2.04498077
21	ZFX_18555785_ChIP-Seq_MESCs_Mouse	2.02260798
22	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.01431744
23	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.89158292
24	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.87747900
25	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.87483186
26	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.83469526
27	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.83326196
28	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.82985297
29	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.81103491
30	DCP1A_22483619_ChIP-Seq_HELA_Human	1.78848531
31	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.75970772
32	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.73117906
33	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.71591886
34	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.69378079
35	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.67094584
36	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.66815951
37	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.66723024
38	* MYC_22102868_ChIP-Seq_BL_Human	1.63946328
39	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.63535355
40	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.62943552
41	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.60398717
42	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.57187041
43	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.53874167
44	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.52892349
45	* GABP_19822575_ChIP-Seq_HepG2_Human	1.52613812
46	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.52565997
47	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.50881734
48	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.47112296
49	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.47065113
50	TTF2_22483619_ChIP-Seq_HELA_Human	1.46230364
51	CLOCK_20551151_ChIP-Seq_293T_Human	1.45605557
52	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.43856605
53	* LXR_22292898_ChIP-Seq_THP-1_Human	1.41699651
54	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.40677720
55	KDM5A_27292631_Chip-Seq_BREAST_Human	1.40177336
56	* RACK7_27058665_Chip-Seq_MCF-7_Human	1.38505168
57	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.36736319
58	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.35345346
59	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.30800885
60	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.30625542
61	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.29337957
62	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.28616048
63	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.27006734
64	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.26252716
65	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.25309946
66	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.23908629
67	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.23140115
68	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.18577428
69	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.16794892
70	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.16280654
71	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.15208293
72	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.15012829
73	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.13145727
74	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.10939606
75	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.10384446
76	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.08088465
77	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.06816629
78	CHD1_26751641_Chip-Seq_LNCaP_Human	1.04619236
79	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	1.04090956
80	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.03776995
81	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.03697156
82	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.03380256
83	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.03315877
84	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.03132063
85	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	1.02869915
86	NANOG_21062744_ChIP-ChIP_HESCs_Human	1.01202954
87	ATF3_27146783_Chip-Seq_COLON_Human	1.00937405
88	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.00619985
89	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.00199676
90	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.97829800
91	TP63_17297297_ChIP-ChIP_HaCaT_Human	0.97369872
92	P68_20966046_ChIP-Seq_HELA_Human	0.96041963
93	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.95692313
94	* KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.95306639
95	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.94255490
96	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.93907047
97	TFEB_21752829_ChIP-Seq_HELA_Human	0.93414969
98	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.92916582
99	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.92498404
100	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.92437582

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010094_abnormal_chromosome_stability	3.11815305
2	MP0003111_abnormal_nucleus_morphology	3.02038054
3	MP0010234_abnormal_vibrissa_follicle	3.00612732
4	MP0004859_abnormal_synaptic_plasticity	2.80487370
5	MP0003693_abnormal_embryo_hatching	2.70141817
6	MP0002877_abnormal_melanocyte_morpholog	2.64288213
7	MP0004233_abnormal_muscle_weight	2.61161183
8	MP0004270_analgesia	2.27757612
9	MP0003077_abnormal_cell_cycle	2.26682773
10	MP0004957_abnormal_blastocyst_morpholog	2.19032100
11	MP0005171_absent_coat_pigmentation	2.18403579
12	MP0003123_paternal_imprinting	2.14700601
13	MP0008932_abnormal_embryonic_tissue	2.09930052
14	MP0000372_irregular_coat_pigmentation	2.06494941
15	MP0005451_abnormal_body_composition	1.86554072
16	MP0000751_myopathy	1.76040976
17	MP0008057_abnormal_DNA_replication	1.65181290
18	MP0001730_embryonic_growth_arrest	1.64827452
19	MP0000747_muscle_weakness	1.63210840
20	MP0008058_abnormal_DNA_repair	1.62860027
21	MP0008007_abnormal_cellular_replicative	1.61955503
22	MP0005257_abnormal_intraocular_pressure	1.55711712
23	MP0005408_hypopigmentation	1.48632176
24	MP0009672_abnormal_birth_weight	1.48484961
25	MP0003705_abnormal_hypodermis_morpholog	1.37065283
26	MP0005623_abnormal_meninges_morphology	1.35902681
27	MP0000350_abnormal_cell_proliferation	1.34684234
28	MP0000537_abnormal_urethra_morphology	1.30744397
29	MP0001661_extended_life_span	1.25819398
30	MP0002080_prenatal_lethality	1.25664280
31	MP0000003_abnormal_adipose_tissue	1.25144857
32	MP0005330_cardiomyopathy	1.23554063
33	MP0009046_muscle_twitch	1.23131026
34	MP0001697_abnormal_embryo_size	1.16734953
35	MP0003880_abnormal_central_pattern	1.16251560
36	MP0006036_abnormal_mitochondrial_physio	1.16005564
37	MP0000749_muscle_degeneration	1.15709909
38	MP0002269_muscular_atrophy	1.15463464
39	MP0000678_abnormal_parathyroid_gland	1.13073246
40	MP0001348_abnormal_lacrimal_gland	1.12443397
41	MP0000358_abnormal_cell_content/	1.11149643
42	MP0001672_abnormal_embryogenesis/_devel	1.10889068
43	MP0005380_embryogenesis_phenotype	1.10889068
44	MP0004087_abnormal_muscle_fiber	1.10198330
45	MP0001346_abnormal_lacrimal_gland	1.09953220
46	MP0000579_abnormal_nail_morphology	1.09194642
47	MP0005645_abnormal_hypothalamus_physiol	1.08090614
48	MP0004185_abnormal_adipocyte_glucose	1.07895594
49	MP0003786_premature_aging	1.07870430
50	MP0003635_abnormal_synaptic_transmissio	1.07401143
51	MP0002938_white_spotting	1.05352701
52	MP0002822_catalepsy	1.03355102
53	MP0008569_lethality_at_weaning	1.01681372
54	MP0006035_abnormal_mitochondrial_morpho	0.99589653
55	MP0001529_abnormal_vocalization	0.99585728
56	MP0003984_embryonic_growth_retardation	0.99504756
57	MP0002064_seizures	0.98398100
58	MP0002063_abnormal_learning/memory/cond	0.97216057
59	MP0005076_abnormal_cell_differentiation	0.96235152
60	MP0002088_abnormal_embryonic_growth/wei	0.93242163
61	MP0001849_ear_inflammation	0.92301591
62	MP0005666_abnormal_adipose_tissue	0.92267626
63	MP0005423_abnormal_somatic_nervous	0.92219245
64	MP0000015_abnormal_ear_pigmentation	0.91746203
65	MP0003221_abnormal_cardiomyocyte_apopto	0.89736899
66	MP0004811_abnormal_neuron_physiology	0.89102774
67	MP0003806_abnormal_nucleotide_metabolis	0.88918762
68	MP0009780_abnormal_chondrocyte_physiolo	0.88287775
69	MP0002075_abnormal_coat/hair_pigmentati	0.87129547
70	MP0005670_abnormal_white_adipose	0.87008207
71	MP0003122_maternal_imprinting	0.85723026
72	MP0000566_synostosis	0.85583280
73	MP0005375_adipose_tissue_phenotype	0.85152319
74	MP0000759_abnormal_skeletal_muscle	0.83867194
75	MP0008260_abnormal_autophagy	0.83797649
76	MP0003315_abnormal_perineum_morphology	0.83685713
77	MP0004858_abnormal_nervous_system	0.83486549
78	MP0002085_abnormal_embryonic_tissue	0.83280908
79	MP0010630_abnormal_cardiac_muscle	0.82853784
80	MP0010030_abnormal_orbit_morphology	0.82667276
81	MP0000750_abnormal_muscle_regeneration	0.82439874
82	MP0002090_abnormal_vision	0.80457917
83	MP0003329_amyloid_beta_deposits	0.80384532
84	MP0001186_pigmentation_phenotype	0.79456171
85	MP0000313_abnormal_cell_death	0.77062110
86	MP0005384_cellular_phenotype	0.76395138
87	MP0004197_abnormal_fetal_growth/weight/	0.75173852
88	MP0002734_abnormal_mechanical_nocicepti	0.74164816
89	MP0010352_gastrointestinal_tract_polyps	0.72867841
90	MP0004272_abnormal_basement_membrane	0.71021507
91	MP0002249_abnormal_larynx_morphology	0.69954637
92	MP0004381_abnormal_hair_follicle	0.68518322
93	MP0005187_abnormal_penis_morphology	0.68287313
94	MP0002084_abnormal_developmental_patter	0.67824044
95	MP0002106_abnormal_muscle_physiology	0.66269579
96	MP0003566_abnormal_cell_adhesion	0.65688660
97	MP0002184_abnormal_innervation	0.65021122
98	MP0002086_abnormal_extraembryonic_tissu	0.64912164
99	MP0009745_abnormal_behavioral_response	0.64885632
100	MP0002066_abnormal_motor_capabilities/c	0.64555308

Predicted human phenotypes

Rank	Gene Set	Z-score
1	* Abnormal gallbladder physiology (HP:0012438)	6.01029789
2	* Cholecystitis (HP:0001082)	6.01029789
3	* Abnormality of glycolysis (HP:0004366)	4.28432753
4	Increased serum pyruvate (HP:0003542)	4.28432753
5	Exercise-induced muscle cramps (HP:0003710)	3.32628433
6	Hyperacusis (HP:0010780)	3.24558341
7	Insomnia (HP:0100785)	3.08104018
8	* Cholelithiasis (HP:0001081)	2.90504761
9	Reticulocytosis (HP:0001923)	2.78102460
10	Myoglobinuria (HP:0002913)	2.75369883
11	Increased nuchal translucency (HP:0010880)	2.75198370
12	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.64068809
13	* Abnormal gallbladder morphology (HP:0012437)	2.59198960
14	Chromsome breakage (HP:0040012)	2.53065991
15	Microvesicular hepatic steatosis (HP:0001414)	2.46613024
16	Rhabdomyolysis (HP:0003201)	2.44758364
17	Hypokinesia (HP:0002375)	2.43592083
18	Ragged-red muscle fibers (HP:0003200)	2.34572657
19	Upper limb amyotrophy (HP:0009129)	2.34194487
20	Distal upper limb amyotrophy (HP:0007149)	2.34194487
21	* Abnormality of the gallbladder (HP:0005264)	2.33250048
22	Dysmetric saccades (HP:0000641)	2.32447222
23	Multiple enchondromatosis (HP:0005701)	2.29121003
24	Cerebral hypomyelination (HP:0006808)	2.22666873
25	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.20578306
26	Hand muscle atrophy (HP:0009130)	2.18983215
27	Myokymia (HP:0002411)	2.18871339
28	Septate vagina (HP:0001153)	2.18344884
29	Abnormality of reticulocytes (HP:0004312)	2.14147645
30	Birth length less than 3rd percentile (HP:0003561)	2.04296358
31	Upper limb muscle weakness (HP:0003484)	2.04102169
32	Pointed chin (HP:0000307)	1.98479674
33	Elfin facies (HP:0004428)	1.97320664
34	Ependymoma (HP:0002888)	1.94065954
35	Overriding aorta (HP:0002623)	1.93795745
36	Exercise-induced myalgia (HP:0003738)	1.93507525
37	Distal lower limb amyotrophy (HP:0008944)	1.93261757
38	Testicular atrophy (HP:0000029)	1.92884346
39	Progressive muscle weakness (HP:0003323)	1.91382216
40	Abnormality of the astrocytes (HP:0100707)	1.90065017
41	Astrocytoma (HP:0009592)	1.90065017
42	Lower limb amyotrophy (HP:0007210)	1.88602378
43	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.87912636
44	Termporal pattern (HP:0011008)	1.86941650
45	Insidious onset (HP:0003587)	1.86941650
46	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.86521554
47	Myopathic facies (HP:0002058)	1.85704340
48	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.85585658
49	Absent epiphyses (HP:0010577)	1.85585658
50	Hammertoe (HP:0001765)	1.84900933
51	Distal sensory impairment (HP:0002936)	1.79427148
52	Gout (HP:0001997)	1.75173596
53	Long palpebral fissure (HP:0000637)	1.73994011
54	Pheochromocytoma (HP:0002666)	1.73697867
55	Impaired pain sensation (HP:0007328)	1.72634482
56	Abnormality of pain sensation (HP:0010832)	1.72634482
57	Microglossia (HP:0000171)	1.70624871
58	Proximal placement of thumb (HP:0009623)	1.69935331
59	Heterochromia iridis (HP:0001100)	1.69925296
60	Ankle clonus (HP:0011448)	1.65736815
61	Trismus (HP:0000211)	1.64510553
62	Cortical dysplasia (HP:0002539)	1.64332115
63	Progressive external ophthalmoplegia (HP:0000590)	1.63692254
64	Truncus arteriosus (HP:0001660)	1.63539070
65	Abnormality of the anterior horn cell (HP:0006802)	1.62987294
66	Degeneration of anterior horn cells (HP:0002398)	1.62987294
67	Deviation of the thumb (HP:0009603)	1.62781414
68	Orthostatic hypotension (HP:0001278)	1.62352464
69	Depression (HP:0000716)	1.62320881
70	Muscle stiffness (HP:0003552)	1.60964149
71	CNS hypomyelination (HP:0003429)	1.60691623
72	High anterior hairline (HP:0009890)	1.60313871
73	Postnatal microcephaly (HP:0005484)	1.60247601
74	Hypopigmentation of the fundus (HP:0007894)	1.57838776
75	Achilles tendon contracture (HP:0001771)	1.56113835
76	Diminished movement (HP:0002374)	1.54961121
77	Abnormality of cochlea (HP:0000375)	1.54407330
78	Stridor (HP:0010307)	1.52739357
79	Overlapping toe (HP:0001845)	1.50327343
80	Foot dorsiflexor weakness (HP:0009027)	1.50062160
81	Precocious puberty (HP:0000826)	1.49994668
82	Renal duplication (HP:0000075)	1.49360606
83	Athetosis (HP:0002305)	1.48300282
84	Neonatal death (HP:0003811)	1.47424101
85	Exercise intolerance (HP:0003546)	1.46795960
86	Macroorchidism (HP:0000053)	1.45901114
87	Supranuclear gaze palsy (HP:0000605)	1.45142158
88	Annular pancreas (HP:0001734)	1.44538535
89	Cafe-au-lait spot (HP:0000957)	1.44494762
90	Nuclear cataract (HP:0100018)	1.43834916
91	Asymmetry of the thorax (HP:0001555)	1.43598612
92	Progressive hearing impairment (HP:0001730)	1.43497336
93	Tetraplegia (HP:0002445)	1.43197503
94	Abnormality of the Achilles tendon (HP:0005109)	1.42640502
95	Glossoptosis (HP:0000162)	1.42285834
96	Visual hallucinations (HP:0002367)	1.41861076
97	Pterygium (HP:0001059)	1.41110852
98	Adducted thumb (HP:0001181)	1.41077144
99	Abnormal cartilage morphology (HP:0002763)	1.40155460
100	Back pain (HP:0003418)	1.39723757

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EEF2K	3.56233253
2	NEK1	3.49257384
3	PKN2	3.27178821
4	TRIB3	3.21467243
5	SMG1	3.07392853
6	BUB1	3.05161631
7	EIF2AK1	2.55025398
8	ICK	2.50602743
9	PRKD3	2.25941837
10	NME2	2.22359920
11	TSSK6	2.20341028
12	TTK	1.82641027
13	CDC7	1.78717155
14	ARAF	1.70222761
15	MAP3K9	1.69267163
16	PAK6	1.68930738
17	WEE1	1.63234655
18	BRSK1	1.63194715
19	CDK12	1.58546358
20	PDK2	1.55693120
21	VRK2	1.48535527
22	IRAK3	1.48224789
23	MST1R	1.43308390
24	SRPK1	1.27850792
25	PBK	1.27507632
26	KSR2	1.25014129
27	SCYL2	1.24551274
28	PHKG2	1.20435638
29	PHKG1	1.20435638
30	LATS2	1.20195920
31	LMTK2	1.20019430
32	SIK1	1.18583871
33	DAPK1	1.15994461
34	BCKDK	1.09376801
35	EPHA2	1.03011699
36	BRAF	1.01777934
37	RPS6KB2	1.00723075
38	PLK3	0.99536142
39	FLT3	0.96915644
40	AKT2	0.96158703
41	CDK18	0.95030113
42	EPHA4	0.93696216
43	ALK	0.93677622
44	PAK4	0.93126783
45	CDK15	0.92649704
46	NTRK1	0.91252221
47	CDK7	0.91055469
48	CDK11A	0.88481640
49	MAPKAPK5	0.88300586
50	MARK1	0.87617386
51	NME1	0.87235757
52	ATR	0.85081930
53	MINK1	0.83996282
54	MAP3K8	0.83745925
55	PLK2	0.81615794
56	CDK14	0.80533115
57	CHEK1	0.80316436
58	CHEK2	0.77804533
59	CCNB1	0.77160322
60	AURKA	0.76375127
61	TESK1	0.74732479
62	MTOR	0.72342183
63	TTN	0.70629943
64	RAF1	0.70299058
65	MAPKAPK3	0.69343527
66	PLK1	0.69149287
67	SIK3	0.64740184
68	PTK2	0.64503907
69	TRIM28	0.63593911
70	EIF2AK3	0.63551779
71	FGFR4	0.63542644
72	PRPF4B	0.63030346
73	MAPK11	0.62010207
74	LIMK1	0.60785732
75	AURKB	0.59108248
76	CDK1	0.58347654
77	FGFR1	0.57007850
78	PRKCI	0.56016506
79	NEK2	0.53590683
80	UHMK1	0.53198659
81	FER	0.52063713
82	SIK2	0.51877338
83	PAK1	0.50970737
84	CDK2	0.49723870
85	KSR1	0.49240693
86	MET	0.48565193
87	CAMK1D	0.46308412
88	NEK6	0.46123507
89	CAMK2B	0.46066219
90	NTRK3	0.45078442
91	CSNK1G3	0.44827213
92	CDK8	0.44353693
93	CSNK1A1L	0.42545320
94	TAF1	0.42477105
95	ILK	0.42182745
96	PIM2	0.40604894
97	PRKAA1	0.40517671
98	CAMK2G	0.38436007
99	ATM	0.38283401
100	EIF2AK2	0.36785448

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	3.52416947
2	Biosynthesis of amino acids_Homo sapiens_hsa01230	3.46799981
3	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	3.35361652
4	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.84949297
5	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.78056232
6	* Carbon metabolism_Homo sapiens_hsa01200	2.76279523
7	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.62127554
8	* Pentose phosphate pathway_Homo sapiens_hsa00030	2.54879065
9	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.51484397
10	DNA replication_Homo sapiens_hsa03030	2.49204137
11	* Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	2.41729717
12	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.26821860
13	Pyruvate metabolism_Homo sapiens_hsa00620	1.84701801
14	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.73058207
15	One carbon pool by folate_Homo sapiens_hsa00670	1.71427362
16	Mismatch repair_Homo sapiens_hsa03430	1.64279810
17	Galactose metabolism_Homo sapiens_hsa00052	1.64267584
18	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.60956237
19	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.56214928
20	Base excision repair_Homo sapiens_hsa03410	1.51958544
21	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.50652700
22	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.42048089
23	Arginine and proline metabolism_Homo sapiens_hsa00330	1.37447165
24	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.33668027
25	Arginine biosynthesis_Homo sapiens_hsa00220	1.31072693
26	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.25267810
27	RNA transport_Homo sapiens_hsa03013	1.24128157
28	Cell cycle_Homo sapiens_hsa04110	1.23233824
29	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.21348943
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.19269533
31	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.18804857
32	Proteasome_Homo sapiens_hsa03050	1.18658420
33	Fatty acid elongation_Homo sapiens_hsa00062	1.17961853
34	Non-homologous end-joining_Homo sapiens_hsa03450	1.13183678
35	Lysine degradation_Homo sapiens_hsa00310	1.10002280
36	Vibrio cholerae infection_Homo sapiens_hsa05110	1.06501895
37	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.05433068
38	Sulfur relay system_Homo sapiens_hsa04122	1.03443026
39	Fatty acid metabolism_Homo sapiens_hsa01212	0.96030816
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.95388785
41	Oocyte meiosis_Homo sapiens_hsa04114	0.94699129
42	Steroid biosynthesis_Homo sapiens_hsa00100	0.94486023
43	Nucleotide excision repair_Homo sapiens_hsa03420	0.93453434
44	mRNA surveillance pathway_Homo sapiens_hsa03015	0.90449805
45	Propanoate metabolism_Homo sapiens_hsa00640	0.90295588
46	Spliceosome_Homo sapiens_hsa03040	0.85562344
47	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.85124931
48	Glucagon signaling pathway_Homo sapiens_hsa04922	0.80058314
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.79821924
50	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.77460951
51	Homologous recombination_Homo sapiens_hsa03440	0.76737238
52	Pyrimidine metabolism_Homo sapiens_hsa00240	0.76028629
53	Phenylalanine metabolism_Homo sapiens_hsa00360	0.76015143
54	AMPK signaling pathway_Homo sapiens_hsa04152	0.74179251
55	Insulin signaling pathway_Homo sapiens_hsa04910	0.65366328
56	* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.64043546
57	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.60958418
58	Purine metabolism_Homo sapiens_hsa00230	0.59431834
59	Folate biosynthesis_Homo sapiens_hsa00790	0.58894800
60	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.58751168
61	Long-term potentiation_Homo sapiens_hsa04720	0.57804144
62	Thyroid cancer_Homo sapiens_hsa05216	0.57548702
63	Alcoholism_Homo sapiens_hsa05034	0.55418831
64	Glutathione metabolism_Homo sapiens_hsa00480	0.51658452
65	Glioma_Homo sapiens_hsa05214	0.51281586
66	Tyrosine metabolism_Homo sapiens_hsa00350	0.50459867
67	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.50274539
68	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.49001137
69	RNA polymerase_Homo sapiens_hsa03020	0.48966234
70	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.47145135
71	RNA degradation_Homo sapiens_hsa03018	0.46491473
72	Amphetamine addiction_Homo sapiens_hsa05031	0.44013247
73	Fanconi anemia pathway_Homo sapiens_hsa03460	0.43537027
74	mTOR signaling pathway_Homo sapiens_hsa04150	0.42973411
75	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.39843220
76	* Metabolic pathways_Homo sapiens_hsa01100	0.38183396
77	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.36969376
78	Tight junction_Homo sapiens_hsa04530	0.36624022
79	Insulin secretion_Homo sapiens_hsa04911	0.35830245
80	Adherens junction_Homo sapiens_hsa04520	0.35419723
81	Prion diseases_Homo sapiens_hsa05020	0.34726278
82	Bladder cancer_Homo sapiens_hsa05219	0.34065471
83	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.33882548
84	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.33721121
85	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.32026970
86	Nicotine addiction_Homo sapiens_hsa05033	0.29700112
87	Non-small cell lung cancer_Homo sapiens_hsa05223	0.29541998
88	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.28766193
89	Endometrial cancer_Homo sapiens_hsa05213	0.28601947
90	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.27964300
91	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.27865266
92	Parkinsons disease_Homo sapiens_hsa05012	0.27420406
93	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.24817093
94	Melanogenesis_Homo sapiens_hsa04916	0.23765029
95	Estrogen signaling pathway_Homo sapiens_hsa04915	0.23021250
96	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.22215851
97	Dopaminergic synapse_Homo sapiens_hsa04728	0.21966221
98	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.21874475
99	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.21708863
100	ErbB signaling pathway_Homo sapiens_hsa04012	0.21537840

GPI

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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