GPKOW

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a putative RNA-binding protein containing G-patch and KOW (Kyprides, Ouzounis, Woese) domains. The encoded protein interacts directly with protein kinase A and protein kinase X and is also found associated with the spliceosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.16943135
2protein maturation by protein folding (GO:0022417)4.94142667
3positive regulation of mitotic sister chromatid separation (GO:1901970)4.69792013
4positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.69792013
5positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.69792013
6metallo-sulfur cluster assembly (GO:0031163)4.66529181
7iron-sulfur cluster assembly (GO:0016226)4.66529181
8negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.59798280
9proteasome assembly (GO:0043248)4.51649234
10COPI coating of Golgi vesicle (GO:0048205)4.36034706
11Golgi transport vesicle coating (GO:0048200)4.36034706
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.32502756
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.32502756
14negative regulation of T cell receptor signaling pathway (GO:0050860)4.26283766
15chaperone mediated protein folding requiring cofactor (GO:0051085)4.19609192
16deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.06452930
17antigen processing and presentation of endogenous antigen (GO:0019883)4.02328915
18hepatocyte apoptotic process (GO:0097284)3.94521347
19purine nucleobase biosynthetic process (GO:0009113)3.92176848
20positive regulation of chromosome segregation (GO:0051984)3.82903161
21protein targeting to mitochondrion (GO:0006626)3.77835337
22eosinophil chemotaxis (GO:0048245)3.72708097
23negative regulation of Ras GTPase activity (GO:0034261)3.66828647
24autophagic vacuole fusion (GO:0000046)3.65067765
25ribosomal small subunit biogenesis (GO:0042274)3.64915253
26glucocorticoid receptor signaling pathway (GO:0042921)3.61137455
27protein prenylation (GO:0018342)3.56557323
28prenylation (GO:0097354)3.56557323
29regulation of mononuclear cell migration (GO:0071675)3.50175280
30cellular response to zinc ion (GO:0071294)3.47905663
31epithelial cell differentiation involved in prostate gland development (GO:0060742)3.46168186
32establishment of protein localization to mitochondrion (GO:0072655)3.45676812
33protein localization to kinetochore (GO:0034501)3.45232188
34nucleobase biosynthetic process (GO:0046112)3.43588572
35negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.42091120
36positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.41229725
37regulation of mammary gland epithelial cell proliferation (GO:0033599)3.36040396
38NADH metabolic process (GO:0006734)3.34292847
39megakaryocyte development (GO:0035855)3.33361231
40pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.33138461
41pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.33063318
42vesicle fusion (GO:0006906)3.32970077
43eosinophil migration (GO:0072677)3.29544702
44regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.29063109
45telomere maintenance via recombination (GO:0000722)3.28580617
46protein localization to mitochondrion (GO:0070585)3.25366806
47tolerance induction (GO:0002507)3.22805977
48regulation of B cell receptor signaling pathway (GO:0050855)3.22590497
49regulation of interleukin-12 biosynthetic process (GO:0045075)3.20958160
50deoxyribose phosphate biosynthetic process (GO:0046385)3.19889346
512-deoxyribonucleotide biosynthetic process (GO:0009265)3.19889346
52non-recombinational repair (GO:0000726)3.19057856
53double-strand break repair via nonhomologous end joining (GO:0006303)3.19057856
543-UTR-mediated mRNA stabilization (GO:0070935)3.19051426
55regulation of gamma-delta T cell differentiation (GO:0045586)3.16085251
56transcription-coupled nucleotide-excision repair (GO:0006283)3.15828638
57positive regulation of gamma-delta T cell activation (GO:0046645)3.14457194
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14168876
59activated T cell proliferation (GO:0050798)3.13075495
60coenzyme A biosynthetic process (GO:0015937)3.12161809
61negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.11416615
62negative regulation of cell killing (GO:0031342)3.11416615
63B cell receptor signaling pathway (GO:0050853)3.10238152
64corticosteroid receptor signaling pathway (GO:0031958)3.05998757
65positive regulation of tolerance induction (GO:0002645)3.04881672
66mitotic sister chromatid cohesion (GO:0007064)3.03925214
677-methylguanosine mRNA capping (GO:0006370)3.03106492
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.03104587
69peptidyl-lysine dimethylation (GO:0018027)3.00740165
70termination of RNA polymerase III transcription (GO:0006386)3.00491537
71transcription elongation from RNA polymerase III promoter (GO:0006385)3.00491537
72organelle fusion (GO:0048284)2.99960126
73regulation of cellular amino acid metabolic process (GO:0006521)2.99657143
74DNA unwinding involved in DNA replication (GO:0006268)2.99073275
75neuron projection extension involved in neuron projection guidance (GO:1902284)2.98804934
76axon extension involved in axon guidance (GO:0048846)2.98804934
77positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.98535503
78positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.97573142
79mitochondrial fusion (GO:0008053)2.95716252
80regulation of spindle organization (GO:0090224)2.93475631
81maturation of SSU-rRNA (GO:0030490)2.92958697
82anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.92885400
83sodium ion export (GO:0071436)2.92727594
84negative regulation of phagocytosis (GO:0050765)2.92422432
85negative regulation of fibroblast apoptotic process (GO:2000270)2.91949782
86negative regulation of ligase activity (GO:0051352)2.91760652
87negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.91760652
887-methylguanosine RNA capping (GO:0009452)2.91161984
89RNA capping (GO:0036260)2.91161984
90regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88370008
91negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.88261850
92valine metabolic process (GO:0006573)2.88112512
93negative thymic T cell selection (GO:0045060)2.87971338
94negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.86251278
95GDP-mannose metabolic process (GO:0019673)2.86098018
96histone mRNA catabolic process (GO:0071044)2.85813581
97macrophage chemotaxis (GO:0048246)2.85755731
98pentose-phosphate shunt (GO:0006098)2.85517639
99pyrimidine nucleotide catabolic process (GO:0006244)2.85251808
100antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.84430614
101leukocyte cell-cell adhesion (GO:0007159)2.82254489
102negative T cell selection (GO:0043383)2.81281772
103regulation of T cell tolerance induction (GO:0002664)2.80861993
104cytoplasmic mRNA processing body assembly (GO:0033962)2.80715965
105establishment of nucleus localization (GO:0040023)2.80053910
106positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.79232171
107deoxyribonucleotide biosynthetic process (GO:0009263)2.78147522
108negative regulation of sodium ion transport (GO:0010766)2.78025336
109mitochondrial genome maintenance (GO:0000002)2.77851957
110negative regulation of fatty acid transport (GO:2000192)2.77814242
111regulation of sister chromatid cohesion (GO:0007063)2.77604558
112branch elongation of an epithelium (GO:0060602)2.77225264
113mitotic recombination (GO:0006312)2.77144385
114organelle membrane fusion (GO:0090174)2.76324501
115nucleobase-containing small molecule interconversion (GO:0015949)2.76022768
116DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.74232433
117peptidyl-arginine omega-N-methylation (GO:0035247)2.74028093
118DNA strand elongation involved in DNA replication (GO:0006271)2.72796907
119negative regulation of myeloid cell apoptotic process (GO:0033033)2.72311861
120chaperone-mediated protein transport (GO:0072321)2.70710367
121Arp2/3 complex-mediated actin nucleation (GO:0034314)2.70578907
122viral transcription (GO:0019083)2.70014995
123regulation of tolerance induction (GO:0002643)2.69932017
124intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.68594792
125signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.68594792
126regulation of NFAT protein import into nucleus (GO:0051532)2.67896922
127protein localization to chromosome, centromeric region (GO:0071459)2.67511181
128establishment of endothelial barrier (GO:0061028)2.67210383
129positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.67137330
130DNA strand elongation (GO:0022616)2.65475895
131telomere maintenance via semi-conservative replication (GO:0032201)2.63916918
132regulation of RNA export from nucleus (GO:0046831)2.63544687
133signal transduction involved in DNA damage checkpoint (GO:0072422)2.62640688
134signal transduction involved in DNA integrity checkpoint (GO:0072401)2.62640688
135tRNA modification (GO:0006400)2.62207361
136B cell homeostasis (GO:0001782)2.62087896
137signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.61857476
138signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.61857476
139signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.61857476
140ncRNA 3-end processing (GO:0043628)2.61813673
141pentose metabolic process (GO:0019321)2.61495694
142guanosine-containing compound biosynthetic process (GO:1901070)2.61482604
143pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.60164308
144translesion synthesis (GO:0019985)2.59550509
145regulation of protein heterodimerization activity (GO:0043497)2.59001995
146virion assembly (GO:0019068)2.58626519
147pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.57784789
148regulation of macrophage cytokine production (GO:0010935)2.57666592
149NLS-bearing protein import into nucleus (GO:0006607)2.57627914
150signal transduction involved in cell cycle checkpoint (GO:0072395)2.57511267
151positive regulation of viral transcription (GO:0050434)2.55937454
152positive regulation of ligase activity (GO:0051351)2.55834816
153regulation of T cell receptor signaling pathway (GO:0050856)2.55168915
154regulation of transforming growth factor beta2 production (GO:0032909)2.55038885
155leukocyte aggregation (GO:0070486)2.54335690
156regulation of B cell differentiation (GO:0045577)2.54232723
157execution phase of apoptosis (GO:0097194)2.54068135
158regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.53877274
159monoubiquitinated protein deubiquitination (GO:0035520)2.53155513
160regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.52986742
161folic acid-containing compound biosynthetic process (GO:0009396)2.52973008
162embryonic hemopoiesis (GO:0035162)2.51163095
163regulation of extracellular matrix disassembly (GO:0010715)2.51112212
164protein targeting to lysosome (GO:0006622)2.50935116
165establishment of protein localization to vacuole (GO:0072666)2.50935116
166protein targeting to vacuole (GO:0006623)2.50935116
167retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.50857404
168snRNA processing (GO:0016180)2.49700922
169response to interleukin-15 (GO:0070672)2.49369655
170xenobiotic catabolic process (GO:0042178)2.48260418
171ribonucleoprotein complex biogenesis (GO:0022613)2.47929189
172regulation of gamma-delta T cell activation (GO:0046643)2.46044738
173regulation of erythrocyte differentiation (GO:0045646)2.45189698
174positive regulation of erythrocyte differentiation (GO:0045648)2.44895628
175oxaloacetate metabolic process (GO:0006107)2.42922603
176positive regulation of interleukin-2 production (GO:0032743)2.41287690
177nuclear pore complex assembly (GO:0051292)2.41093340
178histone H3-K36 demethylation (GO:0070544)2.40516466
179T cell costimulation (GO:0031295)2.39995528
180hippo signaling (GO:0035329)2.39005504
181negative regulation of potassium ion transmembrane transport (GO:1901380)2.37997887
182positive regulation of macrophage cytokine production (GO:0060907)2.36304034
183mitotic chromosome condensation (GO:0007076)2.35673256
184microtubule nucleation (GO:0007020)2.34179844
185lymphocyte costimulation (GO:0031294)2.34058930
186interferon-gamma production (GO:0032609)2.32253737
187tricarboxylic acid cycle (GO:0006099)2.31916755
188coronary vasculature morphogenesis (GO:0060977)2.30364679
189JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.30047415
190regulation of germinal center formation (GO:0002634)2.27834006
191histamine transport (GO:0051608)2.27325131
192histone-serine phosphorylation (GO:0035404)2.26424125
193heterotypic cell-cell adhesion (GO:0034113)2.26371300
194DNA topological change (GO:0006265)2.26145083
195positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.25780782
196positive regulation of cell cycle G2/M phase transition (GO:1902751)2.25780782
197lymph vessel development (GO:0001945)2.24799285
198activation of MAPKKK activity (GO:0000185)2.23766326

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.14830413
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.62060498
3EGR1_19374776_ChIP-ChIP_THP-1_Human5.45897116
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.41577707
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.82243554
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.53535338
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.47457645
8MYC_22102868_ChIP-Seq_BL_Human3.31473643
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.11452021
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.08647067
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.08520197
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.80109642
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79116465
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.71416262
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.69997050
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.67905177
17AR_21909140_ChIP-Seq_LNCAP_Human2.65904429
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.65209331
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.60033275
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.57543975
21* ETS1_20019798_ChIP-Seq_JURKAT_Human2.52252871
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.40165086
23GATA1_22025678_ChIP-Seq_K562_Human2.36361057
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.33802497
25RUNX_20019798_ChIP-Seq_JUKART_Human2.31184802
26YY1_21170310_ChIP-Seq_MESCs_Mouse2.30770906
27CLOCK_20551151_ChIP-Seq_293T_Human2.26435221
28GABP_17652178_ChIP-ChIP_JURKAT_Human2.20824272
29ZNF263_19887448_ChIP-Seq_K562_Human2.20462931
30CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17945274
31SRY_22984422_ChIP-ChIP_TESTIS_Rat2.07443675
32MYB_21317192_ChIP-Seq_ERMYB_Mouse2.06576825
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.05934008
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05578308
35MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04808806
36XRN2_22483619_ChIP-Seq_HELA_Human1.97088553
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96187492
38GABP_19822575_ChIP-Seq_HepG2_Human1.91794898
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89863729
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.89494561
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.89200543
42TCF7_22412390_ChIP-Seq_EML_Mouse1.88492452
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88266044
44MAF_26560356_Chip-Seq_TH1_Human1.87579817
45UTX_26944678_Chip-Seq_JUKART_Human1.84332247
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.83444371
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.82777923
48* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80728964
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78909482
50MYB_26560356_Chip-Seq_TH1_Human1.77989290
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.77594405
52DCP1A_22483619_ChIP-Seq_HELA_Human1.77230554
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.75911839
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.75863707
55MYB_26560356_Chip-Seq_TH2_Human1.75376803
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72525645
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71715483
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71193305
59KDM2B_26808549_Chip-Seq_DND41_Human1.69221028
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.68126705
61STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67863798
62VDR_21846776_ChIP-Seq_THP-1_Human1.64312758
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.62713535
64FOXP3_21729870_ChIP-Seq_TREG_Human1.61831615
65FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.59745365
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58043760
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57688459
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57593809
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54942735
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.54085690
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53915255
72DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.49216599
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.48070624
74LXR_22292898_ChIP-Seq_THP-1_Human1.47849390
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46479537
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45282908
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42593971
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42076776
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41349417
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40820249
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40414360
82IRF8_27001747_Chip-Seq_BMDM_Mouse1.40276114
83CIITA_25753668_ChIP-Seq_RAJI_Human1.39939966
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37983251
85RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.37961120
86E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37495835
87* VDR_23849224_ChIP-Seq_CD4+_Human1.37185098
88SPI1_23127762_ChIP-Seq_K562_Human1.36348731
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36308150
90CHD1_26751641_Chip-Seq_LNCaP_Human1.35512223
91ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35467542
92NCOR1_26117541_ChIP-Seq_K562_Human1.34605208
93TTF2_22483619_ChIP-Seq_HELA_Human1.33466068
94IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33056259
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32100349
96VDR_24763502_ChIP-Seq_THP-1_Human1.31898550
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.30411549
98STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30355895
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29742426
100ELK3_25401928_ChIP-Seq_HUVEC_Human1.29108233
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28220547
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27771573
103TFEB_21752829_ChIP-Seq_HELA_Human1.27529177
104BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27100183
105PKCTHETA_26484144_Chip-Seq_BREAST_Human1.27048681
106WT1_19549856_ChIP-ChIP_CCG9911_Human1.26702126
107WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25659472
108GATA3_27048872_Chip-Seq_THYMUS_Human1.24495933
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24205545
110HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23412936
111STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22130639
112NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22073212
113TET1_21451524_ChIP-Seq_MESCs_Mouse1.21934682
114NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21160601
115KDM2B_26808549_Chip-Seq_JURKAT_Human1.20700653
116* BCL6_27268052_Chip-Seq_Bcells_Human1.20087597
117* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18755691
118MAF_26560356_Chip-Seq_TH2_Human1.17998005
119P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17987398
120SPI1_23547873_ChIP-Seq_NB4_Human1.17020305
121IRF8_22096565_ChIP-ChIP_GC-B_Human1.16536890
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15653192
123IRF8_21731497_ChIP-ChIP_J774_Mouse1.15139082
124P68_20966046_ChIP-Seq_HELA_Human1.14723907
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14482408
126CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14391459
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13340032
128RUNX1_22412390_ChIP-Seq_EML_Mouse1.12594406
129KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11425228
130FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09612506
131FOXO3_23340844_ChIP-Seq_DLD1_Human1.09582953
132CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09286660
133RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08736516
134TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06354227
135ELF1_20517297_ChIP-Seq_JURKAT_Human1.06062458
136TRIM28_21343339_ChIP-Seq_HEK293_Human1.05487531
137TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04407057
138SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03941394
139RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03531888
140CTCF_26484167_Chip-Seq_Bcells_Mouse1.03431609
141CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03270728
142ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03254318
143TP63_17297297_ChIP-ChIP_HaCaT_Human1.02865901
144GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02692408
145MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02660489
146SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02601515
147HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02275411
148TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02256607
149SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01684312
150PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01489771
151RACK7_27058665_Chip-Seq_MCF-7_Human1.01230354
152ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00648623
153PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.00380114
154BCOR_27268052_Chip-Seq_Bcells_Human0.99939559
155PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99664137
156NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98444694
157CTCF_21964334_Chip-Seq_Bcells_Human0.98117664
158E2F1_21310950_ChIP-Seq_MCF-7_Human0.97804765
159POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97631672
160FOXP1_21924763_ChIP-Seq_HESCs_Human0.97465153
161SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97398519
162MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96996707
163GATA3_26560356_Chip-Seq_TH2_Human0.95394656
164PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94126272
165FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.92858777
166GATA1_19941827_ChIP-Seq_MEL_Mouse0.91148831
167ATF3_27146783_Chip-Seq_COLON_Human0.90818474
168GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89971787
169CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89564745
170AR_21572438_ChIP-Seq_LNCaP_Human0.88748023
171KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88373689
172PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88131291
173* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86227835
174TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85705460
175VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84030564
176IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.83073728
177SCL_19346495_ChIP-Seq_HPC-7_Human0.82359036
178VDR_24787735_ChIP-Seq_THP-1_Human0.81760875
179CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.80995523

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.69573835
2MP0005451_abnormal_body_composition3.30770054
3MP0008260_abnormal_autophagy3.26947262
4MP0006082_CNS_inflammation3.15039537
5MP0002396_abnormal_hematopoietic_system3.10406195
6MP0003303_peritoneal_inflammation3.03926082
7MP0000566_synostosis3.01346930
8MP0003806_abnormal_nucleotide_metabolis2.94877026
9MP0004808_abnormal_hematopoietic_stem2.55463638
10MP0010352_gastrointestinal_tract_polyps2.55059627
11MP0008057_abnormal_DNA_replication2.44179508
12MP0008058_abnormal_DNA_repair2.42481591
13MP0003111_abnormal_nucleus_morphology2.29420102
14MP0005076_abnormal_cell_differentiation2.11538866
15MP0006036_abnormal_mitochondrial_physio2.08866849
16MP0008007_abnormal_cellular_replicative2.08542599
17MP0000858_altered_metastatic_potential1.99300467
18MP0003763_abnormal_thymus_physiology1.98570775
19MP0001545_abnormal_hematopoietic_system1.95086504
20MP0005397_hematopoietic_system_phenotyp1.95086504
21MP0000749_muscle_degeneration1.90503475
22MP0001800_abnormal_humoral_immune1.90479313
23MP0003123_paternal_imprinting1.89622276
24MP0000358_abnormal_cell_content/1.83225365
25MP0005025_abnormal_response_to1.82908293
26MP0001835_abnormal_antigen_presentation1.81991312
27MP0008932_abnormal_embryonic_tissue1.78004438
28MP0003186_abnormal_redox_activity1.76591405
29MP0002398_abnormal_bone_marrow1.71969208
30MP0005671_abnormal_response_to1.69604587
31MP0002132_abnormal_respiratory_system1.67524519
32MP0006035_abnormal_mitochondrial_morpho1.67518811
33MP0005387_immune_system_phenotype1.66599823
34MP0001790_abnormal_immune_system1.66599823
35MP0002166_altered_tumor_susceptibility1.64968220
36MP0009053_abnormal_anal_canal1.64392954
37MP0009785_altered_susceptibility_to1.61477629
38MP0002420_abnormal_adaptive_immunity1.60319145
39MP0002452_abnormal_antigen_presenting1.60235145
40MP0008961_abnormal_basal_metabolism1.60094599
41MP0000678_abnormal_parathyroid_gland1.59346869
42MP0003329_amyloid_beta_deposits1.58416711
43MP0003787_abnormal_imprinting1.57947400
44MP0000750_abnormal_muscle_regeneration1.56903090
45MP0003943_abnormal_hepatobiliary_system1.55036943
46MP0001819_abnormal_immune_cell1.54119374
47MP0000465_gastrointestinal_hemorrhage1.51461096
48MP0000703_abnormal_thymus_morphology1.50314235
49MP0004084_abnormal_cardiac_muscle1.50265048
50MP0002722_abnormal_immune_system1.47814973
51MP0004957_abnormal_blastocyst_morpholog1.47346532
52MP0003693_abnormal_embryo_hatching1.47334433
53MP0003786_premature_aging1.46508988
54MP0010368_abnormal_lymphatic_system1.46099024
55MP0006054_spinal_hemorrhage1.45919228
56MP0000689_abnormal_spleen_morphology1.45798989
57MP0000716_abnormal_immune_system1.44898756
58MP0001853_heart_inflammation1.44065886
59MP0004233_abnormal_muscle_weight1.43103381
60MP0000681_abnormal_thyroid_gland1.42762243
61MP0003705_abnormal_hypodermis_morpholog1.41886605
62MP0009278_abnormal_bone_marrow1.41841790
63MP0009840_abnormal_foam_cell1.40234572
64MP0005670_abnormal_white_adipose1.39157616
65MP0002723_abnormal_immune_serum1.37763310
66MP0003984_embryonic_growth_retardation1.33142990
67MP0001663_abnormal_digestive_system1.32404407
68MP0002405_respiratory_system_inflammati1.32030717
69MP0009333_abnormal_splenocyte_physiolog1.31651885
70MP0001919_abnormal_reproductive_system1.31578326
71MP0005166_decreased_susceptibility_to1.31553360
72MP0005501_abnormal_skin_physiology1.31347370
73MP0000467_abnormal_esophagus_morphology1.30542506
74MP0005000_abnormal_immune_tolerance1.30203733
75MP0000313_abnormal_cell_death1.28952702
76MP0002088_abnormal_embryonic_growth/wei1.28722463
77MP0002429_abnormal_blood_cell1.27960576
78MP0003077_abnormal_cell_cycle1.27613878
79MP0000350_abnormal_cell_proliferation1.27344597
80MP0003221_abnormal_cardiomyocyte_apopto1.27189673
81MP0003436_decreased_susceptibility_to1.26029664
82MP0002148_abnormal_hypersensitivity_rea1.25977351
83MP0003828_pulmonary_edema1.25556529
84MP0001873_stomach_inflammation1.24086188
85MP0000685_abnormal_immune_system1.22664849
86MP0002877_abnormal_melanocyte_morpholog1.20181217
87MP0001730_embryonic_growth_arrest1.19995412
88MP0003866_abnormal_defecation1.19757799
89MP0003075_altered_response_to1.19541358
90MP0004947_skin_inflammation1.19402984
91MP0002419_abnormal_innate_immunity1.15687319
92MP0003121_genomic_imprinting1.15036786
93MP0008877_abnormal_DNA_methylation1.11398319
94MP0000490_abnormal_crypts_of1.11320443
95MP0001661_extended_life_span1.11144328
96MP0001879_abnormal_lymphatic_vessel1.10913985
97MP0009384_cardiac_valve_regurgitation1.10095361
98MP0004858_abnormal_nervous_system1.10043053
99MP0010094_abnormal_chromosome_stability1.09289390
100MP0003453_abnormal_keratinocyte_physiol1.07317096
101MP0002090_abnormal_vision1.06898866
102MP0003566_abnormal_cell_adhesion1.06472037
103MP0010155_abnormal_intestine_physiology1.05423476
104MP0002006_tumorigenesis1.04530885
105MP0005058_abnormal_lysosome_morphology1.04460518
106MP0008469_abnormal_protein_level1.04028220
107MP0005499_abnormal_olfactory_system1.03979835
108MP0005394_taste/olfaction_phenotype1.03979835
109MP0002234_abnormal_pharynx_morphology1.03549524
110MP0004147_increased_porphyrin_level1.03150325
111MP0005381_digestive/alimentary_phenotyp1.02924280
112MP0001849_ear_inflammation1.01591957
113MP0003656_abnormal_erythrocyte_physiolo0.99980574
114MP0010630_abnormal_cardiac_muscle0.99585875
115MP0010307_abnormal_tumor_latency0.97831741
116MP0001664_abnormal_digestion0.97802848
117MP0001672_abnormal_embryogenesis/_devel0.97106191
118MP0005380_embryogenesis_phenotype0.97106191
119MP0001727_abnormal_embryo_implantation0.94036856
120MP0003567_abnormal_fetal_cardiomyocyte0.93453050
121MP0001764_abnormal_homeostasis0.93131083
122MP0000343_altered_response_to0.92203666
123MP0001845_abnormal_inflammatory_respons0.92151740
124MP0002998_abnormal_bone_remodeling0.91830286
125MP0000013_abnormal_adipose_tissue0.91528159
126MP0005023_abnormal_wound_healing0.91381088
127MP0004484_altered_response_of0.90897716
128MP0002933_joint_inflammation0.89880468
129MP0000733_abnormal_muscle_development0.89820117
130MP0005187_abnormal_penis_morphology0.89316784
131MP0003448_altered_tumor_morphology0.89051906
132MP0000747_muscle_weakness0.88640738
133MP0000383_abnormal_hair_follicle0.88551560
134MP0003646_muscle_fatigue0.88452199
135MP0002086_abnormal_extraembryonic_tissu0.88446047
136MP0004036_abnormal_muscle_relaxation0.88416017
137MP0003091_abnormal_cell_migration0.88181147
138MP0004197_abnormal_fetal_growth/weight/0.87648047
139MP0000604_amyloidosis0.87578409
140MP0001905_abnormal_dopamine_level0.87520433
141MP0005464_abnormal_platelet_physiology0.87347789
142MP0003122_maternal_imprinting0.87176955
143MP0001915_intracranial_hemorrhage0.86616458
144MP0002653_abnormal_ependyma_morphology0.86136557
145MP0004185_abnormal_adipocyte_glucose0.85850061
146MP0000759_abnormal_skeletal_muscle0.84951724
147MP0005384_cellular_phenotype0.84645724
148MP0005621_abnormal_cell_physiology0.84317614
149MP0001851_eye_inflammation0.83811558
150MP0002332_abnormal_exercise_endurance0.82819674
151MP0002019_abnormal_tumor_incidence0.82036720
152MP0001697_abnormal_embryo_size0.81865706
153MP0002128_abnormal_blood_circulation0.81797154
154MP0002925_abnormal_cardiovascular_devel0.81351149
155MP0009763_increased_sensitivity_to0.81260440
156MP0002080_prenatal_lethality0.80041033
157MP0002210_abnormal_sex_determination0.74639834
158MP0006292_abnormal_olfactory_placode0.71007359
159MP0005319_abnormal_enzyme/_coenzyme0.69556860

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of long-chain fatty-acid metabolism (HP:0010964)5.34846319
2Progressive muscle weakness (HP:0003323)5.25212453
3Abnormality of fatty-acid metabolism (HP:0004359)3.83427437
4Rhabdomyolysis (HP:0003201)3.53149456
5Abnormal mitochondria in muscle tissue (HP:0008316)3.52733192
6Abnormal gallbladder physiology (HP:0012438)3.48943216
7Cholecystitis (HP:0001082)3.48943216
8Increased intramyocellular lipid droplets (HP:0012240)3.37217072
9Acute necrotizing encephalopathy (HP:0006965)3.27693949
10Ragged-red muscle fibers (HP:0003200)3.25285834
11Mitochondrial inheritance (HP:0001427)3.18316155
12Aplastic anemia (HP:0001915)3.17614705
13Hematochezia (HP:0002573)3.15902277
14Reduced subcutaneous adipose tissue (HP:0003758)3.10510472
15Increased muscle lipid content (HP:0009058)3.05023911
16Exercise intolerance (HP:0003546)3.03228429
17Lactic acidosis (HP:0003128)3.00605741
18Recurrent viral infections (HP:0004429)2.97691257
19Short 4th metacarpal (HP:0010044)2.96088026
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.96088026
21Hypertensive crisis (HP:0100735)2.90454350
22Hepatocellular necrosis (HP:0001404)2.83456593
23Acute encephalopathy (HP:0006846)2.79029156
24Myoglobinuria (HP:0002913)2.74672719
25Microvesicular hepatic steatosis (HP:0001414)2.73665852
26Hepatic necrosis (HP:0002605)2.70046846
27Increased CSF lactate (HP:0002490)2.68574516
28IgM deficiency (HP:0002850)2.60286192
29Autoamputation (HP:0001218)2.60280117
30Increased serum lactate (HP:0002151)2.59094228
31Increased serum pyruvate (HP:0003542)2.58709809
32Vertebral arch anomaly (HP:0008438)2.58416928
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.57222029
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.57222029
35Spontaneous hematomas (HP:0007420)2.55023868
36Progressive macrocephaly (HP:0004481)2.52810228
37Polycythemia (HP:0001901)2.51771851
38Recurrent fungal infections (HP:0002841)2.50778752
39Abnormality of the fingertips (HP:0001211)2.50579051
40Hypoplastic pelvis (HP:0008839)2.49406661
41Abnormality of glycolysis (HP:0004366)2.49383748
42Purpura (HP:0000979)2.48326961
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.47228430
44Increased hepatocellular lipid droplets (HP:0006565)2.47189409
45Long foot (HP:0001833)2.46308978
46Megalencephaly (HP:0001355)2.45477928
47Trigonocephaly (HP:0000243)2.44610077
48Cutis marmorata (HP:0000965)2.43598706
49Renal Fanconi syndrome (HP:0001994)2.42919460
50Aplasia/Hypoplasia of the sacrum (HP:0008517)2.39025681
51Subacute progressive viral hepatitis (HP:0006572)2.38096289
52Shoulder girdle muscle weakness (HP:0003547)2.37370027
53Duplicated collecting system (HP:0000081)2.35544125
54Pelvic girdle muscle weakness (HP:0003749)2.34772825
55Papilloma (HP:0012740)2.34350468
56Verrucae (HP:0200043)2.34350468
57Colon cancer (HP:0003003)2.33281050
58Lymphopenia (HP:0001888)2.32438084
59Abnormality of the distal phalanges of the toes (HP:0010182)2.31061498
60Cerebral aneurysm (HP:0004944)2.30448040
61Prolonged neonatal jaundice (HP:0006579)2.29724272
62Increased cerebral lipofuscin (HP:0011813)2.28971041
63Hyperthyroidism (HP:0000836)2.27427077
64Cellulitis (HP:0100658)2.25855680
65Centrally nucleated skeletal muscle fibers (HP:0003687)2.24953968
66Abnormality of cells of the lymphoid lineage (HP:0012140)2.24692794
67Truncus arteriosus (HP:0001660)2.24254390
68Lipid accumulation in hepatocytes (HP:0006561)2.23182549
69Pustule (HP:0200039)2.22476013
70Chronic otitis media (HP:0000389)2.22382874
71Arterial tortuosity (HP:0005116)2.22194151
72Petechiae (HP:0000967)2.21918673
73Abnormality of the tricuspid valve (HP:0001702)2.21215998
74Reticulocytosis (HP:0001923)2.20953548
75Spondylolisthesis (HP:0003302)2.19592967
76Autoimmune thrombocytopenia (HP:0001973)2.19234229
77Myopathic facies (HP:0002058)2.17266325
78Respiratory failure (HP:0002878)2.17230805
79Generalized amyotrophy (HP:0003700)2.16645714
80Elevated erythrocyte sedimentation rate (HP:0003565)2.16266125
81Mitral stenosis (HP:0001718)2.15801609
82Transitional cell carcinoma of the bladder (HP:0006740)2.15031782
83Menstrual irregularities (HP:0000858)2.14539772
84Pancytopenia (HP:0001876)2.13593662
85Abnormality of the 4th metacarpal (HP:0010012)2.12700941
86Emotional lability (HP:0000712)2.12358892
87Cerebral edema (HP:0002181)2.11380626
88Rectal prolapse (HP:0002035)2.10697268
89Narrow palate (HP:0000189)2.10635991
90Vertebral compression fractures (HP:0002953)2.08228857
91Persistence of primary teeth (HP:0006335)2.08091489
92Ankle contracture (HP:0006466)2.08056820
93Striae distensae (HP:0001065)2.07578338
94Abnormality of cells of the erythroid lineage (HP:0012130)2.07412341
95Respiratory difficulties (HP:0002880)2.07013575
96Bicuspid aortic valve (HP:0001647)2.06454397
97Abnormality of B cell number (HP:0010975)2.06342597
98B lymphocytopenia (HP:0010976)2.06342597
99Chorioretinal atrophy (HP:0000533)2.06331638
100Abnormality of the renal collecting system (HP:0004742)2.05507518
101Increased IgM level (HP:0003496)2.03714660
102Abnormal number of erythroid precursors (HP:0012131)2.03703565
103Cerebral hypomyelination (HP:0006808)2.03270504
104Abnormality of reticulocytes (HP:0004312)2.02633367
105Mucopolysacchariduria (HP:0008155)2.02600406
106Urinary glycosaminoglycan excretion (HP:0003541)2.02600406
107Broad distal phalanx of finger (HP:0009836)2.01946803
108Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01890925
109Aortic aneurysm (HP:0004942)2.01743597
110Degeneration of anterior horn cells (HP:0002398)2.01095074
111Abnormality of the anterior horn cell (HP:0006802)2.01095074
112Ureteral duplication (HP:0000073)2.00609631
113Recurrent abscess formation (HP:0002722)2.00601170
114Fatigue (HP:0012378)1.99592020
115Viral hepatitis (HP:0006562)1.99503582
116Gastrointestinal stroma tumor (HP:0100723)1.98786304
117Cholelithiasis (HP:0001081)1.98198265
118Esophageal neoplasm (HP:0100751)1.98018101
119Neoplasm of head and neck (HP:0012288)1.98018101
120Gastrointestinal carcinoma (HP:0002672)1.96805526
121Malignant gastrointestinal tract tumors (HP:0006749)1.96805526
122Tetraplegia (HP:0002445)1.95848870
123T lymphocytopenia (HP:0005403)1.93735885
124Emphysema (HP:0002097)1.93719205
125Brushfield spots (HP:0001088)1.93472298
126Panhypogammaglobulinemia (HP:0003139)1.93369790
127Increased neuronal autofluorescent lipopigment (HP:0002074)1.93050478
128Acute myeloid leukemia (HP:0004808)1.92343013
129Abnormality of T cells (HP:0002843)1.92272129
130Macroorchidism (HP:0000053)1.92212862
131Vascular tortuosity (HP:0004948)1.91265835
132Recurrent bronchitis (HP:0002837)1.90652487
133Limb-girdle muscle atrophy (HP:0003797)1.90609838
134Atrophy/Degeneration involving motor neurons (HP:0007373)1.90574678
135IgG deficiency (HP:0004315)1.90297129
136Opisthotonus (HP:0002179)1.89921017
137Periodontitis (HP:0000704)1.89723730
138Overfolded helix (HP:0000396)1.89650357
139Thyroiditis (HP:0100646)1.89005332
140Diaphragmatic weakness (HP:0009113)1.88719860
141Achilles tendon contracture (HP:0001771)1.88266539
142Abnormal platelet volume (HP:0011876)1.86908224
143Chronic obstructive pulmonary disease (HP:0006510)1.86906767
144Obstructive lung disease (HP:0006536)1.86906767
145Lymphedema (HP:0001004)1.86895246
146Increased serum ferritin (HP:0003281)1.85810993
147Agammaglobulinemia (HP:0004432)1.85725179
148Bladder neoplasm (HP:0009725)1.85723953
149Bladder carcinoma (HP:0002862)1.85723953
150Hyperammonemia (HP:0001987)1.85559088
151Eosinophilia (HP:0001880)1.85350914
152Long eyelashes (HP:0000527)1.85035868
153Hypoparathyroidism (HP:0000829)1.85028450
154Abnormally folded helix (HP:0008544)1.85001171
155Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.84505794
156Abnormality of T cell number (HP:0011839)1.84126898
157Osteolytic defects of the phalanges of the hand (HP:0009771)1.83469504
158Osteolytic defects of the hand bones (HP:0009699)1.83469504
159Chest pain (HP:0100749)1.83274888
160Abnormality of the musculature of the pelvis (HP:0001469)1.82891967
161Abnormality of the hip-girdle musculature (HP:0001445)1.82891967
162Uterine leiomyosarcoma (HP:0002891)1.82562879
163Leiomyosarcoma (HP:0100243)1.82562879
164Leukocytosis (HP:0001974)1.82488012
165Combined immunodeficiency (HP:0005387)1.82410805
166Interstitial pulmonary disease (HP:0006530)1.81042219
167Ureteral stenosis (HP:0000071)1.80352635
168Severe muscular hypotonia (HP:0006829)1.78788646
169Myositis (HP:0100614)1.77895773
170Mesangial abnormality (HP:0001966)1.77432200
171Hepatosplenomegaly (HP:0001433)1.76932949
172Abnormality of eosinophils (HP:0001879)1.76242606
173Abnormality of macrophages (HP:0004311)1.75316389
174Abnormal delayed hypersensitivity skin test (HP:0002963)1.75188510
175Abnormality of the peritoneum (HP:0002585)1.75156108
176CNS demyelination (HP:0007305)1.74992815
177Abnormality of polysaccharide metabolism (HP:0011012)1.74982136
178Abnormality of glycosaminoglycan metabolism (HP:0004371)1.74982136
179Abnormality of mucopolysaccharide metabolism (HP:0011020)1.74982136
180Mediastinal lymphadenopathy (HP:0100721)1.74630984
181Type I transferrin isoform profile (HP:0003642)1.74491194
182Spinal cord lesions (HP:0100561)1.74217400
183Syringomyelia (HP:0003396)1.74217400
184Orchitis (HP:0100796)1.72911986
185Abnormality of the gallbladder (HP:0005264)1.72752155
186Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.72398088
187Atelectasis (HP:0100750)1.72329933
188Abnormal ventriculo-arterial connection (HP:0011563)1.69308419
189Transposition of the great arteries (HP:0001669)1.69308419
190Abnormal connection of the cardiac segments (HP:0011545)1.69308419
191Orthostatic hypotension (HP:0001278)1.68828906
192Dry hair (HP:0011359)1.67598582
193Increased connective tissue (HP:0009025)1.64222372
194Trismus (HP:0000211)1.63991972

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK25.31900037
2TAOK24.18263642
3MAP3K113.89791224
4NME23.62893525
5TESK23.42406742
6MAP3K103.31471894
7MAP3K33.25330091
8STK103.10479795
9MAP4K12.96196897
10MKNK12.79458960
11ERN12.76344593
12TRIB32.66002575
13BUB12.59032046
14STK162.41289276
15TSSK62.36945434
16SRPK12.15439737
17CCNB12.10149160
18ABL22.03211954
19BCKDK1.93022533
20VRK21.88271344
21FGFR41.85574852
22TESK11.82605539
23NEK91.82024300
24ITK1.78426007
25FGFR21.76874827
26BRSK21.74650603
27TAOK11.74377824
28BRSK11.73268772
29IRAK31.73160763
30CSF1R1.67580184
31RPS6KA41.67365369
32LRRK21.62382626
33FGFR31.60618443
34CDC71.59522705
35PBK1.59428081
36CDK121.58851625
37EIF2AK11.54117729
38TGFBR21.44859769
39ZAP701.42099422
40SGK31.38334852
41PLK21.37080969
42TYRO31.33161403
43ICK1.27657497
44JAK11.26935810
45MAP3K11.25836688
46TYK21.23549388
47TXK1.23086404
48LIMK11.23081148
49PTK61.22023030
50ARAF1.19160648
51PIM21.18145545
52EEF2K1.17587047
53MARK31.16241683
54KIT1.15699510
55GRK61.14122296
56MST41.13719682
57AURKA1.12343626
58CDK61.07444242
59WEE11.07349997
60NEK11.07066020
61MAP3K81.05891233
62PRPF4B1.03527293
63DYRK1A1.02078979
64TEC1.01643246
65MAP2K30.99486344
66SIK30.98294192
67FRK0.98286329
68FGFR10.97365565
69SGK20.96875226
70CHUK0.96654307
71SIK10.96501651
72TLK10.96241114
73PRKCH0.95155524
74PDK20.94143655
75TTN0.94141186
76NTRK20.92821117
77SCYL20.92328812
78VRK10.91134285
79PAK30.89148284
80PDGFRA0.88795385
81ALK0.88208630
82CDK40.84842692
83BTK0.83239095
84TIE10.82623858
85MAP3K50.79378465
86PIM10.79087026
87TBK10.78129022
88MELK0.77764776
89PKN20.76797042
90SYK0.74722561
91DMPK0.74384329
92CSK0.74366418
93TGFBR10.73112811
94BRAF0.72408403
95PDGFRB0.69269944
96LCK0.69201221
97CHEK20.68869693
98SMG10.68381677
99RET0.68156057
100ZAK0.64151621
101MATK0.63715370
102JAK20.62961625
103NLK0.62665667
104HCK0.61048357
105ACVR1B0.59798619
106DAPK10.58920623
107MTOR0.58906201
108PAK10.57677949
109BRD40.57571874
110SGK4940.56410218
111SGK2230.56410218
112MAP2K70.55827259
113EPHA20.55446133
114KDR0.51651061
115STK40.51151780
116DAPK30.49716593
117CSNK1G20.48831539
118PLK30.47617760
119AURKB0.47406631
120PDK10.47354694
121PAK40.46536203
122LATS10.46061146
123ILK0.45636875
124BMX0.44006804
125EGFR0.43594870
126CSNK2A20.43281741
127ATR0.42237863
128MAPK110.41726683
129ERBB30.40938596
130IRAK40.40653218
131SRC0.40412001
132FES0.40226954
133RPS6KA50.39116034
134CAMK1D0.39061223
135AKT20.39038309
136STK240.38749085
137IGF1R0.37658091
138LYN0.37613921
139JAK30.36725391
140STK30.36265649
141FYN0.36140266
142CLK10.35879306
143MAPKAPK20.35070403
144CDK80.34954417
145MINK10.34592625
146CSNK1G30.34566679
147KSR10.34538582
148CDK70.34049135
149EPHB10.33440859
150PLK10.33090198
151CAMK2G0.33070989
152CDK11A0.32013328
153CSNK2A10.30812137
154TNK20.30804354
155CDK150.30177413
156CDK180.29304671
157RIPK40.27939287
158CHEK10.25487156
159RAF10.25409000
160CDK90.24884743
161MOS0.24513396
162CDK140.24108291
163DYRK1B0.23613455
164IKBKB0.22764096
165PRKCQ0.21763524
166TTK0.19813536
167PRKCD0.19271055

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.82816123
2Sulfur relay system_Homo sapiens_hsa041223.27542693
3RNA polymerase_Homo sapiens_hsa030203.12316403
4Ribosome_Homo sapiens_hsa030103.11179658
5DNA replication_Homo sapiens_hsa030303.10669441
6Fatty acid elongation_Homo sapiens_hsa000622.60525316
7SNARE interactions in vesicular transport_Homo sapiens_hsa041302.59264200
8Pyrimidine metabolism_Homo sapiens_hsa002402.34901127
9Base excision repair_Homo sapiens_hsa034102.34382011
10Primary immunodeficiency_Homo sapiens_hsa053402.28725611
11B cell receptor signaling pathway_Homo sapiens_hsa046622.06691650
12Parkinsons disease_Homo sapiens_hsa050122.04878716
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.00125174
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.99837932
15Nucleotide excision repair_Homo sapiens_hsa034201.95912574
16Oxidative phosphorylation_Homo sapiens_hsa001901.93752081
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.83305159
18One carbon pool by folate_Homo sapiens_hsa006701.81075477
19Leishmaniasis_Homo sapiens_hsa051401.80953929
20Mismatch repair_Homo sapiens_hsa034301.79297196
21Cell cycle_Homo sapiens_hsa041101.75047309
22T cell receptor signaling pathway_Homo sapiens_hsa046601.71654905
23Folate biosynthesis_Homo sapiens_hsa007901.70971398
24Osteoclast differentiation_Homo sapiens_hsa043801.67509227
25Huntingtons disease_Homo sapiens_hsa050161.66140310
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.61265376
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59176029
28Spliceosome_Homo sapiens_hsa030401.58892017
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53941766
30Chronic myeloid leukemia_Homo sapiens_hsa052201.53516047
31Toxoplasmosis_Homo sapiens_hsa051451.53335843
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53154081
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.52198201
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.51563112
35Antigen processing and presentation_Homo sapiens_hsa046121.50802743
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48015348
37Hepatitis B_Homo sapiens_hsa051611.46757378
38Colorectal cancer_Homo sapiens_hsa052101.45143198
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.44991438
40Renal cell carcinoma_Homo sapiens_hsa052111.43583108
41Fructose and mannose metabolism_Homo sapiens_hsa000511.43336315
42Measles_Homo sapiens_hsa051621.42393210
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.41360588
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38468259
45Galactose metabolism_Homo sapiens_hsa000521.37285418
46Viral myocarditis_Homo sapiens_hsa054161.37146853
47Non-small cell lung cancer_Homo sapiens_hsa052231.35643506
48Pancreatic cancer_Homo sapiens_hsa052121.35459859
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.35305819
50Small cell lung cancer_Homo sapiens_hsa052221.33270732
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29949271
52Tuberculosis_Homo sapiens_hsa051521.29004063
53Endometrial cancer_Homo sapiens_hsa052131.28071023
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26739208
55Epstein-Barr virus infection_Homo sapiens_hsa051691.24836750
56Pyruvate metabolism_Homo sapiens_hsa006201.22378053
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20806436
58Alzheimers disease_Homo sapiens_hsa050101.20733088
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18779339
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17975222
61Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17946008
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17648353
63Shigellosis_Homo sapiens_hsa051311.17127572
64Glioma_Homo sapiens_hsa052141.16479889
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14704767
66Intestinal immune network for IgA production_Homo sapiens_hsa046721.13427549
67Thyroid cancer_Homo sapiens_hsa052161.13350503
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.13100864
69mTOR signaling pathway_Homo sapiens_hsa041501.12925510
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12750234
71Cyanoamino acid metabolism_Homo sapiens_hsa004601.10891645
72Cysteine and methionine metabolism_Homo sapiens_hsa002701.10865388
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09343521
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07111419
75Other glycan degradation_Homo sapiens_hsa005111.05673215
76Purine metabolism_Homo sapiens_hsa002301.05163517
77p53 signaling pathway_Homo sapiens_hsa041151.04316508
78Proteoglycans in cancer_Homo sapiens_hsa052051.04052243
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03854619
80FoxO signaling pathway_Homo sapiens_hsa040681.03479118
81MicroRNAs in cancer_Homo sapiens_hsa052061.01968055
82HIF-1 signaling pathway_Homo sapiens_hsa040661.01327411
83Nitrogen metabolism_Homo sapiens_hsa009100.99860471
84Homologous recombination_Homo sapiens_hsa034400.99205913
85Endocytosis_Homo sapiens_hsa041440.98951079
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97140980
87Prolactin signaling pathway_Homo sapiens_hsa049170.96273460
88HTLV-I infection_Homo sapiens_hsa051660.95765999
89TNF signaling pathway_Homo sapiens_hsa046680.95691622
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.95291610
91Synaptic vesicle cycle_Homo sapiens_hsa047210.94572288
92Pentose phosphate pathway_Homo sapiens_hsa000300.94523826
93Insulin resistance_Homo sapiens_hsa049310.93368655
94Platelet activation_Homo sapiens_hsa046110.93279823
95RNA transport_Homo sapiens_hsa030130.93193368
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92927044
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92820914
98Acute myeloid leukemia_Homo sapiens_hsa052210.91960841
99Herpes simplex infection_Homo sapiens_hsa051680.91246317
100Viral carcinogenesis_Homo sapiens_hsa052030.90961183
101Apoptosis_Homo sapiens_hsa042100.88766497
102Prostate cancer_Homo sapiens_hsa052150.88129974
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87836542
104Legionellosis_Homo sapiens_hsa051340.87805669
105VEGF signaling pathway_Homo sapiens_hsa043700.87164353
106Systemic lupus erythematosus_Homo sapiens_hsa053220.86393605
107Fatty acid metabolism_Homo sapiens_hsa012120.85253248
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85032169
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84203040
110Rheumatoid arthritis_Homo sapiens_hsa053230.83590371
111Chemokine signaling pathway_Homo sapiens_hsa040620.83568085
112Lysosome_Homo sapiens_hsa041420.83453841
113Adherens junction_Homo sapiens_hsa045200.83449545
114Influenza A_Homo sapiens_hsa051640.82707498
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80157029
116Hepatitis C_Homo sapiens_hsa051600.78330922
117Arginine and proline metabolism_Homo sapiens_hsa003300.77572505
118Vitamin B6 metabolism_Homo sapiens_hsa007500.77111079
119Collecting duct acid secretion_Homo sapiens_hsa049660.76730182
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75619327
121Glutathione metabolism_Homo sapiens_hsa004800.74056739
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72805256
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.72779980
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70671436
125Focal adhesion_Homo sapiens_hsa045100.70572038
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69324283
127Notch signaling pathway_Homo sapiens_hsa043300.69148101
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.68308427
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68247878
130Biosynthesis of amino acids_Homo sapiens_hsa012300.67331099
131Non-homologous end-joining_Homo sapiens_hsa034500.67092925
132Salmonella infection_Homo sapiens_hsa051320.66885925
133Propanoate metabolism_Homo sapiens_hsa006400.64242925
134Phagosome_Homo sapiens_hsa041450.62354186
135Oocyte meiosis_Homo sapiens_hsa041140.61246017
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60314209
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59946902
138Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59874552
139Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58526884
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.58377182
141Carbon metabolism_Homo sapiens_hsa012000.58189029
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57849274
143mRNA surveillance pathway_Homo sapiens_hsa030150.57238587
144Dilated cardiomyopathy_Homo sapiens_hsa054140.57234840
145Phenylalanine metabolism_Homo sapiens_hsa003600.56548279
146Pertussis_Homo sapiens_hsa051330.55987360
147Hematopoietic cell lineage_Homo sapiens_hsa046400.55307031
148Estrogen signaling pathway_Homo sapiens_hsa049150.54796110
149AMPK signaling pathway_Homo sapiens_hsa041520.54399118
150Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53610382
151Metabolic pathways_Homo sapiens_hsa011000.53269478
152Malaria_Homo sapiens_hsa051440.52014608
153Phototransduction_Homo sapiens_hsa047440.51536112
154Vibrio cholerae infection_Homo sapiens_hsa051100.48315846
155Peroxisome_Homo sapiens_hsa041460.47331835
156Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46659797
157Hippo signaling pathway_Homo sapiens_hsa043900.45317803
158Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41617804
159N-Glycan biosynthesis_Homo sapiens_hsa005100.39069276
160Basal transcription factors_Homo sapiens_hsa030220.38110299
161Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37012231
162Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35049161
163Fanconi anemia pathway_Homo sapiens_hsa034600.34602980
164Cardiac muscle contraction_Homo sapiens_hsa042600.33160002
165Alcoholism_Homo sapiens_hsa050340.33087922
166beta-Alanine metabolism_Homo sapiens_hsa004100.31348413
167Bladder cancer_Homo sapiens_hsa052190.30936953
168Prion diseases_Homo sapiens_hsa050200.30786809
169Butanoate metabolism_Homo sapiens_hsa006500.29495808
170Lysine degradation_Homo sapiens_hsa003100.27261136
171Fatty acid degradation_Homo sapiens_hsa000710.24333792

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