GPLD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.21833600
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.21833600
3L-phenylalanine metabolic process (GO:0006558)6.86037305
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.86037305
5aromatic amino acid family catabolic process (GO:0009074)6.44656278
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.22933681
7indole-containing compound catabolic process (GO:0042436)5.81105939
8indolalkylamine catabolic process (GO:0046218)5.81105939
9tryptophan catabolic process (GO:0006569)5.81105939
10bile acid biosynthetic process (GO:0006699)5.76544653
11kynurenine metabolic process (GO:0070189)5.73188003
12alpha-linolenic acid metabolic process (GO:0036109)5.54024325
13high-density lipoprotein particle remodeling (GO:0034375)5.49025911
14glyoxylate metabolic process (GO:0046487)5.48386788
15tryptophan metabolic process (GO:0006568)5.46065601
16urea metabolic process (GO:0019627)5.44535794
17urea cycle (GO:0000050)5.44535794
18exogenous drug catabolic process (GO:0042738)5.43194221
19negative regulation of fibrinolysis (GO:0051918)5.30338015
20sulfur amino acid catabolic process (GO:0000098)5.30254598
21complement activation, alternative pathway (GO:0006957)5.20593417
22regulation of protein activation cascade (GO:2000257)5.19104100
23cysteine metabolic process (GO:0006534)5.17174551
24regulation of fibrinolysis (GO:0051917)5.12009397
25protein carboxylation (GO:0018214)5.04556977
26peptidyl-glutamic acid carboxylation (GO:0017187)5.04556977
27reverse cholesterol transport (GO:0043691)5.02462858
28nitrogen cycle metabolic process (GO:0071941)4.98931863
29regulation of cholesterol esterification (GO:0010872)4.94433385
30serine family amino acid catabolic process (GO:0009071)4.91639594
31bile acid metabolic process (GO:0008206)4.90825929
32behavioral response to nicotine (GO:0035095)4.90248224
33plasma lipoprotein particle remodeling (GO:0034369)4.85595873
34protein-lipid complex remodeling (GO:0034368)4.85595873
35macromolecular complex remodeling (GO:0034367)4.85595873
36regulation of complement activation (GO:0030449)4.85549443
37homocysteine metabolic process (GO:0050667)4.69958526
38aromatic amino acid family metabolic process (GO:0009072)4.66183601
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.62540684
40alpha-amino acid catabolic process (GO:1901606)4.56548706
41lysine metabolic process (GO:0006553)4.55137605
42lysine catabolic process (GO:0006554)4.55137605
43tyrosine metabolic process (GO:0006570)4.54433064
44amino-acid betaine metabolic process (GO:0006577)4.50829725
45phospholipid efflux (GO:0033700)4.48502652
46negative regulation of sterol transport (GO:0032372)4.44651989
47negative regulation of cholesterol transport (GO:0032375)4.44651989
48glutamate metabolic process (GO:0006536)4.44372929
49low-density lipoprotein particle remodeling (GO:0034374)4.42141443
50dicarboxylic acid biosynthetic process (GO:0043650)4.34028259
51oxidative demethylation (GO:0070989)4.33911214
52triglyceride homeostasis (GO:0070328)4.33873036
53acylglycerol homeostasis (GO:0055090)4.33873036
54cellular ketone body metabolic process (GO:0046950)4.31418257
55cellular modified amino acid catabolic process (GO:0042219)4.26308853
56cellular amino acid catabolic process (GO:0009063)4.24977238
57coenzyme catabolic process (GO:0009109)4.24371438
58* regulation of triglyceride catabolic process (GO:0010896)4.18216199
59cholesterol efflux (GO:0033344)4.15678534
60bile acid and bile salt transport (GO:0015721)4.14778821
61plasma lipoprotein particle clearance (GO:0034381)4.11493963
62indolalkylamine metabolic process (GO:0006586)4.10985382
63plasma lipoprotein particle assembly (GO:0034377)4.07352470
64glycine metabolic process (GO:0006544)4.06098645
65amine catabolic process (GO:0009310)4.02247429
66cellular biogenic amine catabolic process (GO:0042402)4.02247429
67cellular glucuronidation (GO:0052695)4.02183763
68imidazole-containing compound metabolic process (GO:0052803)4.01896753
69omega-hydroxylase P450 pathway (GO:0097267)3.99428576
70ethanol oxidation (GO:0006069)3.98024784
71sulfation (GO:0051923)3.96247528
72serine family amino acid metabolic process (GO:0009069)3.91549603
73water-soluble vitamin biosynthetic process (GO:0042364)3.89043530
74benzene-containing compound metabolic process (GO:0042537)3.84102233
75very-low-density lipoprotein particle assembly (GO:0034379)3.83083044
76arginine metabolic process (GO:0006525)3.80239825
77plasma lipoprotein particle organization (GO:0071827)3.79462839
78serine family amino acid biosynthetic process (GO:0009070)3.76247374
79phospholipid homeostasis (GO:0055091)3.75917490
80fibrinolysis (GO:0042730)3.74710819
81ketone body metabolic process (GO:1902224)3.74274969
82regulation of cholesterol homeostasis (GO:2000188)3.72337471
83drug catabolic process (GO:0042737)3.72025610
84regulation of bile acid biosynthetic process (GO:0070857)3.71871374
85short-chain fatty acid metabolic process (GO:0046459)3.69329289
86epoxygenase P450 pathway (GO:0019373)3.68179799
87complement activation, classical pathway (GO:0006958)3.67638453
88organic acid catabolic process (GO:0016054)3.65267349
89carboxylic acid catabolic process (GO:0046395)3.65267349
90protein-lipid complex assembly (GO:0065005)3.64668789
91gamma-aminobutyric acid transport (GO:0015812)3.64040649
92complement activation (GO:0006956)3.63676145
93positive regulation of lipid catabolic process (GO:0050996)3.60109805
94negative regulation of lipase activity (GO:0060192)3.59776793
95protein activation cascade (GO:0072376)3.59464085
96flavonoid metabolic process (GO:0009812)3.59020325
97cytolysis (GO:0019835)3.56905372
98cholesterol homeostasis (GO:0042632)3.56870342
99blood coagulation, intrinsic pathway (GO:0007597)3.56817761
100protein-lipid complex subunit organization (GO:0071825)3.56478097
101aspartate family amino acid catabolic process (GO:0009068)3.55320514
102uronic acid metabolic process (GO:0006063)3.52913785
103glucuronate metabolic process (GO:0019585)3.52913785
104cofactor catabolic process (GO:0051187)3.52249876
105sterol homeostasis (GO:0055092)3.51752546
106DNA deamination (GO:0045006)3.50159225
107acetyl-CoA metabolic process (GO:0006084)3.49313498
108negative regulation of protein activation cascade (GO:2000258)3.49121633
1092-oxoglutarate metabolic process (GO:0006103)3.45440395
110aldehyde catabolic process (GO:0046185)3.44430246
111response to pheromone (GO:0019236)3.39074019
112indole-containing compound metabolic process (GO:0042430)3.37363536
113detection of light stimulus involved in sensory perception (GO:0050962)3.28696080
114detection of light stimulus involved in visual perception (GO:0050908)3.28696080
115S-adenosylmethionine metabolic process (GO:0046500)3.24908006
116alkaloid metabolic process (GO:0009820)3.21159924
117drug metabolic process (GO:0017144)3.17090278
118pyrimidine nucleobase catabolic process (GO:0006208)3.11207548
119detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.08944615
120dopamine transport (GO:0015872)3.08187764
121amino acid salvage (GO:0043102)2.97844189
122L-methionine salvage (GO:0071267)2.97844189
123L-methionine biosynthetic process (GO:0071265)2.97844189
124mitochondrial respiratory chain complex I assembly (GO:0032981)2.93197454
125NADH dehydrogenase complex assembly (GO:0010257)2.93197454
126mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.93197454
127phenylpropanoid metabolic process (GO:0009698)2.91907960
128membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.84181186
129cell proliferation in forebrain (GO:0021846)2.80421291
130protein polyglutamylation (GO:0018095)2.79115159
131cellular response to ATP (GO:0071318)2.77705887
1323-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.76438008
133purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.76438008
134protein complex biogenesis (GO:0070271)2.74721251
135transmission of nerve impulse (GO:0019226)2.74330936
136primary amino compound metabolic process (GO:1901160)2.74053390
137negative regulation of mast cell activation (GO:0033004)2.73664402
138somite development (GO:0061053)2.73440460
139neuronal action potential (GO:0019228)2.72654572
140negative regulation of transcription regulatory region DNA binding (GO:2000678)2.69853507
141piRNA metabolic process (GO:0034587)2.69631940
142regulation of glucokinase activity (GO:0033131)2.68836069
143regulation of hexokinase activity (GO:1903299)2.68836069
144presynaptic membrane assembly (GO:0097105)2.67435863
145epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.66925708
146serotonin metabolic process (GO:0042428)2.66731041
147nucleobase catabolic process (GO:0046113)2.66412906
148negative regulation of astrocyte differentiation (GO:0048712)2.61970996
149kidney morphogenesis (GO:0060993)2.61078668
150regulation of action potential (GO:0098900)2.60027184
151retinal cone cell development (GO:0046549)2.59872350
152regulation of acrosome reaction (GO:0060046)2.59291596
153negative regulation of synaptic transmission, GABAergic (GO:0032229)2.58913325
154heme transport (GO:0015886)2.57511810
155positive regulation of fatty acid transport (GO:2000193)2.57082001
156epithelial cilium movement (GO:0003351)2.54499866
157positive regulation of fatty acid oxidation (GO:0046321)2.54259492
158reflex (GO:0060004)2.52589112
159vitamin biosynthetic process (GO:0009110)2.50912020
160postsynaptic membrane organization (GO:0001941)2.49663118
161opsonization (GO:0008228)2.49395876
162peristalsis (GO:0030432)2.49343487
163L-fucose catabolic process (GO:0042355)2.48238079
164fucose catabolic process (GO:0019317)2.48238079
165L-fucose metabolic process (GO:0042354)2.48238079
166mitochondrial respiratory chain complex assembly (GO:0033108)2.47516531
167photoreceptor cell development (GO:0042461)2.47016250
168G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.46138774

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.66144668
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.50786740
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.13051022
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.05098072
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.00962716
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.34338303
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.25648090
8EZH2_22144423_ChIP-Seq_EOC_Human4.24790255
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.83807832
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.37154662
11GBX2_23144817_ChIP-Seq_PC3_Human3.07363566
12ZNF274_21170338_ChIP-Seq_K562_Hela2.86566820
13VDR_22108803_ChIP-Seq_LS180_Human2.84952533
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53733974
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.50756590
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.37623114
17IGF1R_20145208_ChIP-Seq_DFB_Human2.26421461
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25061977
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10607506
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06476919
21FUS_26573619_Chip-Seq_HEK293_Human2.05358191
22* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.0024150
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99978481
24P300_19829295_ChIP-Seq_ESCs_Human1.97240817
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.96888005
26EWS_26573619_Chip-Seq_HEK293_Human1.86780551
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77778314
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.77748664
29ER_23166858_ChIP-Seq_MCF-7_Human1.74535321
30FOXA2_19822575_ChIP-Seq_HepG2_Human1.72365861
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.66129794
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64400065
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.63201660
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62297259
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61560796
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60222785
37HTT_18923047_ChIP-ChIP_STHdh_Human1.59991483
38IRF1_19129219_ChIP-ChIP_H3396_Human1.58563792
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.57873363
40STAT3_23295773_ChIP-Seq_U87_Human1.57048025
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56427985
42CBP_20019798_ChIP-Seq_JUKART_Human1.56427985
43SMAD4_21799915_ChIP-Seq_A2780_Human1.55319212
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53879846
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51683415
46TCF4_23295773_ChIP-Seq_U87_Human1.50353218
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.49335894
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48261637
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47715378
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46483581
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46376420
52AR_25329375_ChIP-Seq_VCAP_Human1.45295957
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44873171
54CLOCK_20551151_ChIP-Seq_293T_Human1.44585902
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42000999
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.41480216
57* REST_21632747_ChIP-Seq_MESCs_Mouse1.37985419
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37851128
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37674844
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37472203
61GATA1_22025678_ChIP-Seq_K562_Human1.37010608
62HNF4A_19822575_ChIP-Seq_HepG2_Human1.34859476
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32837696
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.32784644
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32737305
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32249075
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31435501
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31261352
69TCF4_22108803_ChIP-Seq_LS180_Human1.30259353
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28719366
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28719366
72* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28421592
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.27796173
74RNF2_27304074_Chip-Seq_NSC_Mouse1.27746699
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27067177
76NANOG_19829295_ChIP-Seq_ESCs_Human1.26468933
77SOX2_19829295_ChIP-Seq_ESCs_Human1.26468933
78MYC_18940864_ChIP-ChIP_HL60_Human1.26307696
79RUNX2_22187159_ChIP-Seq_PCA_Human1.24583638
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24479470
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.23654981
82EED_16625203_ChIP-ChIP_MESCs_Mouse1.20724296
83JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20161830
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19699258
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17971398
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17376951
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17269806
88TP53_22573176_ChIP-Seq_HFKS_Human1.16781265
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16239928
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.16239928
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.16154282
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.15701816
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15126838
94EZH2_27304074_Chip-Seq_ESCs_Mouse1.14750107
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13125917
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13055319
97NOTCH1_21737748_ChIP-Seq_TLL_Human1.12502116
98NCOR_22424771_ChIP-Seq_293T_Human1.11420186
99FLI1_21867929_ChIP-Seq_TH2_Mouse1.10240407
100CRX_20693478_ChIP-Seq_RETINA_Mouse1.09958492
101EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06149271
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05981306
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05687373
104P53_22387025_ChIP-Seq_ESCs_Mouse1.05504863
105RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04028518
106PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00788783
107* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99699754
108ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99535746
109STAT3_18555785_Chip-Seq_ESCs_Mouse0.99482235
110ESR2_21235772_ChIP-Seq_MCF-7_Human0.98410635
111SOX2_21211035_ChIP-Seq_LN229_Gbm0.98060110
112TAL1_26923725_Chip-Seq_HPCs_Mouse0.97654100
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96051373
114AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94310218
115SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93170532
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93107167
117ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90630970
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87394176
119ERG_21242973_ChIP-ChIP_JURKAT_Human0.85301232
120STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.82631591
121MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.82146721
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80581598
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80581598
124* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78018475
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.75488930
126RARG_19884340_ChIP-ChIP_MEFs_Mouse0.75449808
127GATA4_25053715_ChIP-Seq_YYC3_Human0.72153862
128BCAT_22108803_ChIP-Seq_LS180_Human0.71283899
129IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.68974469
130TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.68444091
131ZNF263_19887448_ChIP-Seq_K562_Human0.67762783
132GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.67720986
133SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.67419562
134SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.66705505
135RARA_24833708_ChIP-Seq_LIVER_Mouse0.63720958
136ESR1_20079471_ChIP-ChIP_T-47D_Human0.63538302
137RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63445914
138LXR_22292898_ChIP-Seq_THP-1_Human0.62100832
139PIAS1_25552417_ChIP-Seq_VCAP_Human0.61875069
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.61011561
141FOXA1_25552417_ChIP-Seq_VCAP_Human0.60367787
142PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.60200706
143BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59836082
144Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.59318759
145SALL4_18804426_ChIP-ChIP_XEN_Mouse0.58754694
146FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.57901215
147CBP_21632823_ChIP-Seq_H3396_Human0.57295666
148DNAJC2_21179169_ChIP-ChIP_NT2_Human0.57203807
149TAF15_26573619_Chip-Seq_HEK293_Human0.56855474
150KAP1_22055183_ChIP-Seq_ESCs_Mouse0.55054891
151CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.54325549
152MYC_19915707_ChIP-ChIP_AK7_Human0.54222817
153EGR1_19032775_ChIP-ChIP_M12_Human0.53466220
154AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.52717535
155FOXO3_23340844_ChIP-Seq_DLD1_Human0.52363459
156* MYC_27129775_Chip-Seq_CORNEA_Mouse0.51515881
157AR_21572438_ChIP-Seq_LNCaP_Human0.51093352
158GATA1_19941826_ChIP-Seq_K562_Human0.50915612
159CDX2_20551321_ChIP-Seq_CACO-2_Human0.50635372
160SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.50543520
161CEBPB_22108803_ChIP-Seq_LS180_Human0.50165571
162PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.50026907
163RARB_24833708_ChIP-Seq_LIVER_Mouse0.49947985
164ESR1_21235772_ChIP-Seq_MCF-7_Human0.49880161
165TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.49846315
166ZNF217_24962896_ChIP-Seq_MCF-7_Human0.49826341
167AR_20517297_ChIP-Seq_VCAP_Human0.49424120
168NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.48716401
169SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.48697334
170CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.48043491
171SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.47616216
172P53_21459846_ChIP-Seq_SAOS-2_Human0.47465825
173TAF2_19829295_ChIP-Seq_ESCs_Human0.46201124
174ESET_19884257_ChIP-Seq_ESCs_Mouse0.46157029
175GATA2_19941826_ChIP-Seq_K562_Human0.45979686
176SMAD4_21741376_ChIP-Seq_HESCs_Human0.45282870
177SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.44891135
178* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.43761990
179PPAR_26484153_Chip-Seq_NCI-H1993_Human0.43745163
180PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43700910
181CDX2_19796622_ChIP-Seq_MESCs_Mouse0.43380375
182FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.43377386
183NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.42923029
184CTCF_27219007_Chip-Seq_Bcells_Human0.42226766
185ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.42221071
186SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.41905729
187CDX2_22108803_ChIP-Seq_LS180_Human0.41729972

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.04253393
2MP0005360_urolithiasis7.39125501
3MP0005085_abnormal_gallbladder_physiolo6.30210420
4MP0005365_abnormal_bile_salt6.09212184
5MP0008875_abnormal_xenobiotic_pharmacok5.02973024
6MP0003252_abnormal_bile_duct3.83805200
7MP0003806_abnormal_nucleotide_metabolis3.82984535
8MP0010329_abnormal_lipoprotein_level3.63865636
9MP0009840_abnormal_foam_cell3.32909031
10MP0005083_abnormal_biliary_tract3.07327878
11MP0006292_abnormal_olfactory_placode3.00659416
12MP0005332_abnormal_amino_acid2.87194596
13MP0003195_calcinosis2.70029986
14MP0001666_abnormal_nutrient_absorption2.59980222
15MP0003191_abnormal_cellular_cholesterol2.25061322
16MP0008877_abnormal_DNA_methylation2.24995464
17MP0005551_abnormal_eye_electrophysiolog2.15323951
18MP0002118_abnormal_lipid_homeostasis2.12657357
19MP0004019_abnormal_vitamin_homeostasis2.11651224
20MP0002102_abnormal_ear_morphology2.10858208
21MP0000609_abnormal_liver_physiology2.07871689
22MP0000569_abnormal_digit_pigmentation1.90112370
23MP0003868_abnormal_feces_composition1.90032144
24MP0003646_muscle_fatigue1.89022235
25MP0003880_abnormal_central_pattern1.87354177
26MP0001968_abnormal_touch/_nociception1.78615355
27MP0002638_abnormal_pupillary_reflex1.75441364
28MP0001485_abnormal_pinna_reflex1.74923616
29MP0005319_abnormal_enzyme/_coenzyme1.74504730
30MP0009745_abnormal_behavioral_response1.68776636
31MP0002138_abnormal_hepatobiliary_system1.67624743
32MP0004142_abnormal_muscle_tone1.66774091
33MP0000631_abnormal_neuroendocrine_gland1.65950201
34MP0005584_abnormal_enzyme/coenzyme_acti1.61041358
35MP0006276_abnormal_autonomic_nervous1.59926764
36MP0002272_abnormal_nervous_system1.58464801
37MP0001764_abnormal_homeostasis1.52701662
38MP0000372_irregular_coat_pigmentation1.51902396
39MP0002254_reproductive_system_inflammat1.51625265
40MP0003011_delayed_dark_adaptation1.50875933
41MP0002736_abnormal_nociception_after1.47132298
42MP0009046_muscle_twitch1.47003590
43MP0006072_abnormal_retinal_apoptosis1.41442568
44MP0003136_yellow_coat_color1.40894082
45MP0009697_abnormal_copulation1.39949899
46MP0005645_abnormal_hypothalamus_physiol1.38518604
47MP0002160_abnormal_reproductive_system1.38363199
48MP0001986_abnormal_taste_sensitivity1.37961201
49MP0000604_amyloidosis1.37618478
50MP0005253_abnormal_eye_physiology1.34848745
51MP0003283_abnormal_digestive_organ1.32973222
52MP0004145_abnormal_muscle_electrophysio1.32026863
53MP0003718_maternal_effect1.31915255
54MP0003656_abnormal_erythrocyte_physiolo1.31858432
55MP0005647_abnormal_sex_gland1.29400536
56MP0001486_abnormal_startle_reflex1.27922657
57MP0005389_reproductive_system_phenotype1.25745048
58MP0002653_abnormal_ependyma_morphology1.25481980
59MP0002064_seizures1.18927898
60MP0005451_abnormal_body_composition1.18488513
61MP0003690_abnormal_glial_cell1.18301035
62MP0009643_abnormal_urine_homeostasis1.17004981
63MP0002735_abnormal_chemical_nociception1.15579337
64MP0003329_amyloid_beta_deposits1.15529519
65MP0000049_abnormal_middle_ear1.13540787
66MP0004133_heterotaxia1.11483188
67MP0003705_abnormal_hypodermis_morpholog1.11473907
68MP0003787_abnormal_imprinting1.09186162
69MP0001501_abnormal_sleep_pattern1.08501369
70MP0003119_abnormal_digestive_system1.07481007
71MP0008789_abnormal_olfactory_epithelium1.07368700
72MP0003635_abnormal_synaptic_transmissio1.06945218
73MP0003890_abnormal_embryonic-extraembry1.06263388
74MP0003186_abnormal_redox_activity1.05171646
75MP0009764_decreased_sensitivity_to1.04025025
76MP0002734_abnormal_mechanical_nocicepti1.03628108
77MP0000598_abnormal_liver_morphology1.01264271
78MP0002557_abnormal_social/conspecific_i1.00966001
79MP0005195_abnormal_posterior_eye1.00622232
80MP0002572_abnormal_emotion/affect_behav0.98700949
81MP0001984_abnormal_olfaction0.98016151
82MP0005379_endocrine/exocrine_gland_phen0.97916783
83MP0001970_abnormal_pain_threshold0.96979036
84MP0002733_abnormal_thermal_nociception0.96291320
85MP0002063_abnormal_learning/memory/cond0.93979947
86MP0001440_abnormal_grooming_behavior0.93748840
87MP0005636_abnormal_mineral_homeostasis0.93560754
88MP0002938_white_spotting0.93241607
89MP0000427_abnormal_hair_cycle0.92851197
90MP0005187_abnormal_penis_morphology0.90479720
91MP0005174_abnormal_tail_pigmentation0.90449890
92MP0000778_abnormal_nervous_system0.90355168
93MP0003938_abnormal_ear_development0.89254267
94MP0009763_increased_sensitivity_to0.89134962
95MP0004924_abnormal_behavior0.88880059
96MP0005386_behavior/neurological_phenoty0.88880059
97MP0003937_abnormal_limbs/digits/tail_de0.88791290
98MP0004134_abnormal_chest_morphology0.87967587
99MP0002822_catalepsy0.86010991
100MP0010386_abnormal_urinary_bladder0.85448207
101MP0002751_abnormal_autonomic_nervous0.85242293
102MP0004147_increased_porphyrin_level0.85195079
103MP0004130_abnormal_muscle_cell0.85161733
104MP0004742_abnormal_vestibular_system0.84540948
105MP0002163_abnormal_gland_morphology0.84525904
106MP0009642_abnormal_blood_homeostasis0.83562729
107MP0000026_abnormal_inner_ear0.83423324
108MP0005535_abnormal_body_temperature0.82849093
109MP0002078_abnormal_glucose_homeostasis0.82830016
110MP0001529_abnormal_vocalization0.82347338
111MP0005670_abnormal_white_adipose0.82001247
112MP0001963_abnormal_hearing_physiology0.81102390
113MP0002282_abnormal_trachea_morphology0.80814160
114MP0001919_abnormal_reproductive_system0.80513599
115MP0002752_abnormal_somatic_nervous0.78183819
116MP0002067_abnormal_sensory_capabilities0.78166949
117MP0001905_abnormal_dopamine_level0.77471699
118MP0002971_abnormal_brown_adipose0.76781713
119MP0002876_abnormal_thyroid_physiology0.76432216
120MP0002909_abnormal_adrenal_gland0.75135939
121MP0005376_homeostasis/metabolism_phenot0.73443034
122MP0008469_abnormal_protein_level0.73383911
123MP0010368_abnormal_lymphatic_system0.73046447
124MP0009765_abnormal_xenobiotic_induced0.71561310
125MP0003075_altered_response_to0.70949060
126MP0000639_abnormal_adrenal_gland0.69703610
127MP0005220_abnormal_exocrine_pancreas0.67865150
128MP0005334_abnormal_fat_pad0.67059475
129MP0006036_abnormal_mitochondrial_physio0.66613833
130MP0005084_abnormal_gallbladder_morpholo0.65440369
131MP0001661_extended_life_span0.64377596
132MP0009384_cardiac_valve_regurgitation0.64273778
133MP0005408_hypopigmentation0.64152742
134MP0001756_abnormal_urination0.63219780
135MP0005448_abnormal_energy_balance0.61381949
136MP0008874_decreased_physiological_sensi0.58371204
137MP0005266_abnormal_metabolism0.55705183
138MP0003638_abnormal_response/metabolism_0.54327956
139MP0005166_decreased_susceptibility_to0.52857695
140MP0000579_abnormal_nail_morphology0.52594478
141MP0008872_abnormal_physiological_respon0.52388684
142MP0002837_dystrophic_cardiac_calcinosis0.50460131
143MP0006035_abnormal_mitochondrial_morpho0.50237238
144MP0004043_abnormal_pH_regulation0.48735275
145MP0003953_abnormal_hormone_level0.48264669
146MP0009053_abnormal_anal_canal0.47814421
147MP0005167_abnormal_blood-brain_barrier0.47005766
148MP0002090_abnormal_vision0.46675731
149MP0005646_abnormal_pituitary_gland0.43576617
150MP0009780_abnormal_chondrocyte_physiolo0.41706907
151MP0005248_abnormal_Harderian_gland0.40655910
152MP0002796_impaired_skin_barrier0.40576994
153MP0003633_abnormal_nervous_system0.40515824
154MP0005395_other_phenotype0.39526259
155MP0000230_abnormal_systemic_arterial0.38523987
156MP0004381_abnormal_hair_follicle0.37827317
157MP0002136_abnormal_kidney_physiology0.37741404
158MP0002928_abnormal_bile_duct0.37637079
159MP0004885_abnormal_endolymph0.37385184
160MP0005666_abnormal_adipose_tissue0.36091963
161MP0005058_abnormal_lysosome_morphology0.35867613
162MP0005464_abnormal_platelet_physiology0.34860728
163MP0010234_abnormal_vibrissa_follicle0.33673563
164MP0009115_abnormal_fat_cell0.33501111
165MP0008873_increased_physiological_sensi0.33080553
166MP0004883_abnormal_blood_vessel0.31492115
167MP0001853_heart_inflammation0.31459091
168MP0003300_gastrointestinal_ulcer0.31121914
169MP0002168_other_aberrant_phenotype0.30068981
170MP0003631_nervous_system_phenotype0.29834651
171MP0001881_abnormal_mammary_gland0.28668186
172MP0001765_abnormal_ion_homeostasis0.28046793
173MP0003632_abnormal_nervous_system0.27876550
174MP0009672_abnormal_birth_weight0.27866202

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.31450762
2Deep venous thrombosis (HP:0002625)7.24929473
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.09834233
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.37921842
5Prolonged partial thromboplastin time (HP:0003645)6.36394906
6Xanthomatosis (HP:0000991)6.30997970
7Hypobetalipoproteinemia (HP:0003563)6.11935675
8Hyperlipoproteinemia (HP:0010980)5.67062769
9Complement deficiency (HP:0004431)5.43689967
10Hypolipoproteinemia (HP:0010981)4.85949391
11Hyperammonemia (HP:0001987)4.64582504
12Joint hemorrhage (HP:0005261)4.52080096
13Hypoalphalipoproteinemia (HP:0003233)4.49688741
14Hyperglycinemia (HP:0002154)4.46356669
15Epidermoid cyst (HP:0200040)4.43600833
16Abnormality of the common coagulation pathway (HP:0010990)4.39741124
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.38002013
18Ketosis (HP:0001946)4.36771456
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.19179668
20Hyperglycinuria (HP:0003108)4.18500650
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.12886305
22Abnormality of serine family amino acid metabolism (HP:0010894)4.11308819
23Abnormality of glycine metabolism (HP:0010895)4.11308819
24Abnormality of methionine metabolism (HP:0010901)4.10792136
25Fat malabsorption (HP:0002630)4.07195358
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.94920618
27Abnormality of complement system (HP:0005339)3.87970682
28Hypoglycemic coma (HP:0001325)3.86259115
29Pancreatic cysts (HP:0001737)3.86228917
30Pancreatic fibrosis (HP:0100732)3.73081077
31Abnormality of the intrinsic pathway (HP:0010989)3.71302047
32Pendular nystagmus (HP:0012043)3.65842574
33Conjugated hyperbilirubinemia (HP:0002908)3.62683099
34Hypercholesterolemia (HP:0003124)3.53427799
35True hermaphroditism (HP:0010459)3.40841322
36Congenital stationary night blindness (HP:0007642)3.40830410
37Abnormality of pyrimidine metabolism (HP:0004353)3.35720903
38Ketoacidosis (HP:0001993)3.27553589
39Hyperbilirubinemia (HP:0002904)3.26081327
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.23216803
41Abnormality of fatty-acid metabolism (HP:0004359)3.15793801
42Delayed CNS myelination (HP:0002188)3.04127013
43Steatorrhea (HP:0002570)3.03967367
44Methylmalonic acidemia (HP:0002912)3.02208787
45Hyperventilation (HP:0002883)2.98596129
46Spontaneous abortion (HP:0005268)2.96790538
47Abnormality of midbrain morphology (HP:0002418)2.94745222
48Molar tooth sign on MRI (HP:0002419)2.94745222
49Myocardial infarction (HP:0001658)2.92383227
50Decreased central vision (HP:0007663)2.91489369
51Abnormality of serum amino acid levels (HP:0003112)2.89457003
52Nephronophthisis (HP:0000090)2.85872935
53Skin nodule (HP:0200036)2.81603743
54Abnormality of nucleobase metabolism (HP:0010932)2.80656740
55Keratoconus (HP:0000563)2.80528340
56Increased corneal curvature (HP:0100692)2.80528340
57Hepatocellular carcinoma (HP:0001402)2.79791495
58Abolished electroretinogram (ERG) (HP:0000550)2.76825753
59Hypochromic microcytic anemia (HP:0004840)2.74133111
60Hypoglycemic seizures (HP:0002173)2.71777487
61Abnormality of the renal cortex (HP:0011035)2.68312534
62Metabolic acidosis (HP:0001942)2.67888851
63Progressive cerebellar ataxia (HP:0002073)2.67482664
64Methylmalonic aciduria (HP:0012120)2.65519050
65Genetic anticipation (HP:0003743)2.63109426
66Amyloidosis (HP:0011034)2.61126620
67Attenuation of retinal blood vessels (HP:0007843)2.57590063
68Acanthocytosis (HP:0001927)2.55796949
69Systemic lupus erythematosus (HP:0002725)2.55025435
70Chronic hepatic failure (HP:0100626)2.54269413
71Abnormality of purine metabolism (HP:0004352)2.53124659
72Gaze-evoked nystagmus (HP:0000640)2.52976574
73Vascular calcification (HP:0004934)2.52294070
74Abnormal gallbladder morphology (HP:0012437)2.49372687
75Lethargy (HP:0001254)2.49297943
76Gout (HP:0001997)2.47739980
77Abnormality of the renal medulla (HP:0100957)2.46661166
78Cholelithiasis (HP:0001081)2.43650160
79Absent rod-and cone-mediated responses on ERG (HP:0007688)2.43156074
80Sensorimotor neuropathy (HP:0007141)2.43070818
81Cystic liver disease (HP:0006706)2.41092091
82Neonatal onset (HP:0003623)2.40630343
83Abnormal rod and cone electroretinograms (HP:0008323)2.39117813
84Medial flaring of the eyebrow (HP:0010747)2.39065420
85Dicarboxylic aciduria (HP:0003215)2.36891511
86Abnormality of dicarboxylic acid metabolism (HP:0010995)2.36891511
87Aplasia/Hypoplasia of the tibia (HP:0005772)2.36029222
88Mitral stenosis (HP:0001718)2.32868487
89Spastic diplegia (HP:0001264)2.32338458
90Irritability (HP:0000737)2.32302267
91Abnormal gallbladder physiology (HP:0012438)2.32271654
92Cholecystitis (HP:0001082)2.32271654
93Glomerulonephritis (HP:0000099)2.31519929
94Status epilepticus (HP:0002133)2.30114924
95Hypothermia (HP:0002045)2.28368032
96Fair hair (HP:0002286)2.26797319
97Renal cortical cysts (HP:0000803)2.26075892
98Cerebral edema (HP:0002181)2.23134520
99Chorioretinal atrophy (HP:0000533)2.22800865
100Cardiovascular calcification (HP:0011915)2.21153751
101Hyperinsulinemic hypoglycemia (HP:0000825)2.18668245
102Bony spicule pigmentary retinopathy (HP:0007737)2.18590435
103Late onset (HP:0003584)2.15888642
104Recurrent gram-negative bacterial infections (HP:0005420)2.14399765
105Brushfield spots (HP:0001088)2.12541365
106Malnutrition (HP:0004395)2.12165458
107Bile duct proliferation (HP:0001408)2.09667391
108Abnormal biliary tract physiology (HP:0012439)2.09667391
109Congenital sensorineural hearing impairment (HP:0008527)2.09416992
110Esophageal varix (HP:0002040)2.09359912
111Sclerocornea (HP:0000647)2.08120820
112Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07392273
113Abnormality of alanine metabolism (HP:0010916)2.07392273
114Hyperalaninemia (HP:0003348)2.07392273
115Aplasia/Hypoplasia of the tongue (HP:0010295)2.06761896
116Enlarged kidneys (HP:0000105)2.05741558
117Pancreatitis (HP:0001733)2.04638076
118Type II lissencephaly (HP:0007260)2.04470533
119Focal motor seizures (HP:0011153)2.04191275
120Confusion (HP:0001289)2.02482406
121Abnormality of the gallbladder (HP:0005264)2.02475903
122Short tibia (HP:0005736)2.01679511
123Abnormality of the renal collecting system (HP:0004742)2.01199688
124Gingival bleeding (HP:0000225)2.01196737
125Inability to walk (HP:0002540)2.01134822
1263-Methylglutaconic aciduria (HP:0003535)1.99850211
127Hydroxyprolinuria (HP:0003080)1.98089708
128Abnormality of proline metabolism (HP:0010907)1.98089708
129Acute necrotizing encephalopathy (HP:0006965)1.97281508
130Back pain (HP:0003418)1.97250998
131Thyroiditis (HP:0100646)1.97170943
132Vomiting (HP:0002013)1.96927618
133Broad-based gait (HP:0002136)1.96243475
134Menorrhagia (HP:0000132)1.95090944
135Poikilocytosis (HP:0004447)1.93242149
136Furrowed tongue (HP:0000221)1.93239936
137Abnormality of DNA repair (HP:0003254)1.92396118
138Anencephaly (HP:0002323)1.92213662
139Agitation (HP:0000713)1.92184848
140Acute encephalopathy (HP:0006846)1.92088291
141Male pseudohermaphroditism (HP:0000037)1.91901414
142Osteomalacia (HP:0002749)1.90936263
143Thrombophlebitis (HP:0004418)1.90328152
144Thyroid-stimulating hormone excess (HP:0002925)1.87576387
145Rickets (HP:0002748)1.85746947
146Opisthotonus (HP:0002179)1.84809355
147Mitochondrial inheritance (HP:0001427)1.84496567
148Short 1st metacarpal (HP:0010034)1.83681328
149Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.83681328
150Hemorrhage of the eye (HP:0011885)1.83228067
151Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83085572
152Progressive macrocephaly (HP:0004481)1.82742805
153Absent speech (HP:0001344)1.82012560
154Hypophosphatemic rickets (HP:0004912)1.81812260
155Dynein arm defect of respiratory motile cilia (HP:0012255)1.80941482
156Absent/shortened dynein arms (HP:0200106)1.80941482
157Tetraplegia (HP:0002445)1.80398625
158Alkalosis (HP:0001948)1.80039071
159Congenital hepatic fibrosis (HP:0002612)1.79927973
160Generalized aminoaciduria (HP:0002909)1.79867637
161Asplenia (HP:0001746)1.78964859
162Gait imbalance (HP:0002141)1.78163828
163Stroke (HP:0001297)1.77971520
164Hemiparesis (HP:0001269)1.77398242
165Aplasia/Hypoplasia of the spleen (HP:0010451)1.77279063
166Symptomatic seizures (HP:0011145)1.76392365
167Abnormality of vitamin B metabolism (HP:0004340)1.75938868
168Focal seizures (HP:0007359)1.75410793
169Clumsiness (HP:0002312)1.74787281
170Postaxial foot polydactyly (HP:0001830)1.74699724
171Increased CSF lactate (HP:0002490)1.74458858
172Polydipsia (HP:0001959)1.74315693
173Abnormal drinking behavior (HP:0030082)1.74315693
174Hyperglycemia (HP:0003074)1.72789689
175Genital tract atresia (HP:0001827)1.72665834
176Congenital, generalized hypertrichosis (HP:0004540)1.72224855
177Tubular atrophy (HP:0000092)1.72004814
178Stomach cancer (HP:0012126)1.71776907
179Elevated hepatic transaminases (HP:0002910)1.71766192
180Abnormality of the vitamin B12 metabolism (HP:0004341)1.71203518
181Abnormality of vitamin metabolism (HP:0100508)1.70914640
182Short hallux (HP:0010109)1.70862723
183Small hand (HP:0200055)1.70457972
184Abnormal cartilage morphology (HP:0002763)1.68319550

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.16683874
2SIK14.61753826
3ERN14.11366824
4FGFR43.73362173
5ADRBK23.02478466
6INSRR2.97506577
7WNK32.92733922
8BMPR1B2.82278299
9TAOK32.68805404
10MAP4K22.63141316
11CASK2.62954904
12ERBB42.62268274
13MAP2K42.56350974
14NUAK12.51637868
15ZAK2.46931493
16EPHA42.40286309
17TLK12.30654859
18ACVR1B2.09986235
19TRIB32.03776528
20MAPK131.91151533
21MST1R1.84069074
22DAPK21.78160371
23PKN21.75087683
24MAPK111.60177686
25FGFR21.53205095
26FRK1.49642987
27PTK61.48850251
28LATS11.47183002
29WNK41.46570871
30PINK11.42887517
31MAP3K71.42025073
32PIK3CG1.41494598
33MARK11.38730405
34LMTK21.35068917
35OXSR11.34062030
36TNIK1.27349794
37JAK21.20233904
38TYK21.18003322
39STK391.16625062
40TRIM281.15056845
41MKNK21.14641068
42SGK31.14414593
43PRKAA21.13292343
44PLK21.10596502
45ERBB21.09227228
46DYRK21.09018963
47FLT31.06142797
48CSNK1G21.05550456
49SGK21.03824919
50MAPK121.02871679
51JAK11.00823390
52PRKCE0.99216624
53VRK10.98090187
54MAP2K70.98075055
55CSNK1G10.95623910
56PHKG20.95228041
57PHKG10.95228041
58BRSK20.95154698
59CAMK2G0.93466357
60CAMK1D0.93225865
61ABL20.92927298
62TXK0.92597555
63PRKCZ0.92540430
64MAPK150.90903062
65MAP3K40.88292185
66ADRBK10.88039813
67SGK2230.86400421
68SGK4940.86400421
69RIPK10.85392087
70PRKACG0.82787511
71STK38L0.82407448
72CSNK1G30.81053259
73PRKAA10.79962230
74MAPK40.77385517
75GRK60.76778174
76PRKCG0.76548068
77CAMKK20.76066664
78NEK90.75860852
79MAP3K20.75656953
80AKT30.73618733
81PDPK10.72427883
82MUSK0.71829021
83RET0.71232226
84MET0.70910376
85VRK20.68887271
86PNCK0.67656076
87GRK50.66386750
88PRKACA0.65947179
89PRKCH0.65236788
90MAPK70.64844233
91CAMK2A0.64323250
92FGFR30.64031572
93CAMK1G0.63628191
94NTRK20.63552821
95MAP3K130.63229020
96CSNK1A10.63138017
97CDK80.62607725
98MAP2K60.62458568
99PLK40.62411345
100TGFBR10.62066783
101KSR20.61530588
102CAMKK10.61359117
103NTRK10.61071088
104BCR0.60670898
105CSNK1A1L0.59965221
106RPS6KA50.59821573
107CDC70.59408515
108STK380.58974241
109EIF2AK30.58893408
110EPHB10.58068110
111PRKCQ0.55910907
112STK110.55764240
113NLK0.55253232
114CSNK1D0.55237399
115PAK30.54650149
116CAMK10.53175331
117BMX0.52737258
118PTK20.52585754
119OBSCN0.52464100
120PDK10.51898786
121ERBB30.51806033
122PDGFRA0.51484239
123DYRK30.50123698
124PKN10.49080075
125PLK30.48328913
126IGF1R0.47818348
127TBK10.47296747
128IKBKB0.46508909
129TEC0.46452662
130KDR0.46404769
131GSK3A0.46340003
132MAP3K10.45731025
133DYRK1B0.44586780
134STK30.44101007
135PRKCI0.43880082
136PRKG10.43392022
137NTRK30.43153299
138DYRK1A0.43107279
139CDK60.43042596
140PRKD20.42533874
141MAP2K10.41703694
142GRK10.41671474
143STK160.41107134
144PRKCA0.41044284
145FER0.40761756
146CAMK40.39112975
147MAP3K90.38893813
148MAPKAPK50.38882851
149EPHA30.38676518
150GRK70.38656390
151WEE10.38282998
152ATR0.38024993
153SGK10.37822116
154MAP2K30.36794261
155CSK0.36788744
156PDK40.36431089
157PDK30.36431089
158IRAK30.36242295
159RPS6KA30.35758119
160MAP3K30.35358795
161TAOK20.35328952
162TIE10.33516344
163ICK0.32971817
164PIK3CA0.32229307
165MAP3K100.31378971
166IRAK20.30589284
167MAP3K110.30528760
168LATS20.30465232

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.43202447
2Nitrogen metabolism_Homo sapiens_hsa009104.38828094
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.30314433
4Arginine biosynthesis_Homo sapiens_hsa002203.17291593
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.12277853
6Complement and coagulation cascades_Homo sapiens_hsa046102.67378967
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.63598342
8Tryptophan metabolism_Homo sapiens_hsa003802.58176012
9Fatty acid degradation_Homo sapiens_hsa000712.56286500
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.54942797
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.42601738
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37851552
13Butanoate metabolism_Homo sapiens_hsa006502.13858967
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.04911406
15Peroxisome_Homo sapiens_hsa041462.00068695
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00046021
17Propanoate metabolism_Homo sapiens_hsa006401.93386165
18Fatty acid metabolism_Homo sapiens_hsa012121.92093437
19PPAR signaling pathway_Homo sapiens_hsa033201.91275985
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.88763007
21Nicotine addiction_Homo sapiens_hsa050331.86567026
22Phototransduction_Homo sapiens_hsa047441.85566629
23Chemical carcinogenesis_Homo sapiens_hsa052041.79561285
24Histidine metabolism_Homo sapiens_hsa003401.78598469
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.75484589
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.74344126
27Bile secretion_Homo sapiens_hsa049761.67059631
28beta-Alanine metabolism_Homo sapiens_hsa004101.65425270
29Caffeine metabolism_Homo sapiens_hsa002321.62548057
30Staphylococcus aureus infection_Homo sapiens_hsa051501.58869048
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55012472
32Retinol metabolism_Homo sapiens_hsa008301.54360039
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.49921310
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49417823
35Phenylalanine metabolism_Homo sapiens_hsa003601.47808670
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47411382
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44438595
38Selenocompound metabolism_Homo sapiens_hsa004501.43348673
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40601157
40Oxidative phosphorylation_Homo sapiens_hsa001901.39806228
41Sulfur metabolism_Homo sapiens_hsa009201.39658181
42* Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36247215
43Tyrosine metabolism_Homo sapiens_hsa003501.35073060
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31091012
45Pyruvate metabolism_Homo sapiens_hsa006201.29134394
46Starch and sucrose metabolism_Homo sapiens_hsa005001.27284935
47Fatty acid elongation_Homo sapiens_hsa000621.25546411
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.24346574
49ABC transporters_Homo sapiens_hsa020101.23310593
50Biosynthesis of amino acids_Homo sapiens_hsa012301.18527524
51Steroid biosynthesis_Homo sapiens_hsa001001.11804588
52Homologous recombination_Homo sapiens_hsa034401.11428507
53Fat digestion and absorption_Homo sapiens_hsa049751.11121812
54Carbon metabolism_Homo sapiens_hsa012001.09436607
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08983293
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06702633
57Arachidonic acid metabolism_Homo sapiens_hsa005901.05933027
58Parkinsons disease_Homo sapiens_hsa050121.05688659
59Protein export_Homo sapiens_hsa030601.04341384
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03998165
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01916866
62Morphine addiction_Homo sapiens_hsa050321.01711397
63Taste transduction_Homo sapiens_hsa047421.00985983
64Folate biosynthesis_Homo sapiens_hsa007900.99219149
65Fanconi anemia pathway_Homo sapiens_hsa034600.97068473
66Fatty acid biosynthesis_Homo sapiens_hsa000610.96283498
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.95054438
68Vitamin B6 metabolism_Homo sapiens_hsa007500.93889627
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.92787696
70Arginine and proline metabolism_Homo sapiens_hsa003300.92432801
71Olfactory transduction_Homo sapiens_hsa047400.88302507
72RNA polymerase_Homo sapiens_hsa030200.85154286
73Sulfur relay system_Homo sapiens_hsa041220.83870459
74Ether lipid metabolism_Homo sapiens_hsa005650.82574726
75Vitamin digestion and absorption_Homo sapiens_hsa049770.82100070
76Serotonergic synapse_Homo sapiens_hsa047260.81811350
77Basal transcription factors_Homo sapiens_hsa030220.79414088
78Lysine degradation_Homo sapiens_hsa003100.77557312
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76107482
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75709466
81Glycerolipid metabolism_Homo sapiens_hsa005610.75114223
82RNA degradation_Homo sapiens_hsa030180.70424647
83Cardiac muscle contraction_Homo sapiens_hsa042600.69827393
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69573684
85Glutamatergic synapse_Homo sapiens_hsa047240.66214029
86Alzheimers disease_Homo sapiens_hsa050100.65869714
87Huntingtons disease_Homo sapiens_hsa050160.65813317
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65125585
89Circadian entrainment_Homo sapiens_hsa047130.59376849
90Glutathione metabolism_Homo sapiens_hsa004800.51650128
91Pentose phosphate pathway_Homo sapiens_hsa000300.50899738
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49433529
93One carbon pool by folate_Homo sapiens_hsa006700.46352189
94Prion diseases_Homo sapiens_hsa050200.43721823
95Dorso-ventral axis formation_Homo sapiens_hsa043200.41506290
96Metabolic pathways_Homo sapiens_hsa011000.41214614
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38343900
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36557064
99Calcium signaling pathway_Homo sapiens_hsa040200.33476469
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.32413217
101Fructose and mannose metabolism_Homo sapiens_hsa000510.31053989
102Cocaine addiction_Homo sapiens_hsa050300.31044835
103Systemic lupus erythematosus_Homo sapiens_hsa053220.30035896
104Salivary secretion_Homo sapiens_hsa049700.30012543
105Dopaminergic synapse_Homo sapiens_hsa047280.28796043
106Insulin resistance_Homo sapiens_hsa049310.28577005
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.28111888
108Galactose metabolism_Homo sapiens_hsa000520.27991391
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25635691
110Purine metabolism_Homo sapiens_hsa002300.21795557
111Collecting duct acid secretion_Homo sapiens_hsa049660.20720544
112Glucagon signaling pathway_Homo sapiens_hsa049220.20272716
113Linoleic acid metabolism_Homo sapiens_hsa005910.18143499
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08271232
115AMPK signaling pathway_Homo sapiens_hsa041520.04369953
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.03753128
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.00796556
118Thyroid hormone synthesis_Homo sapiens_hsa049180.00724609
119Hepatitis C_Homo sapiens_hsa05160-0.1885329
120Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1830223
121Circadian rhythm_Homo sapiens_hsa04710-0.1707284
122Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1649622
123Regulation of autophagy_Homo sapiens_hsa04140-0.1636601
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1626686
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1582718
126Insulin secretion_Homo sapiens_hsa04911-0.1544875
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1419670
128African trypanosomiasis_Homo sapiens_hsa05143-0.1418895
129Mineral absorption_Homo sapiens_hsa04978-0.1326729
130Renin-angiotensin system_Homo sapiens_hsa04614-0.1326500
131Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1265477
132Type II diabetes mellitus_Homo sapiens_hsa04930-0.1236306
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0972055
134GABAergic synapse_Homo sapiens_hsa04727-0.0447862
135Insulin signaling pathway_Homo sapiens_hsa04910-0.0276129
136Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0251867

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »