GPM6A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.81404821
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.62787516
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.61772664
4neuron cell-cell adhesion (GO:0007158)5.46645216
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.43426837
6synaptic vesicle exocytosis (GO:0016079)5.34240008
7protein localization to synapse (GO:0035418)5.19444930
8locomotory exploration behavior (GO:0035641)5.18661335
9ionotropic glutamate receptor signaling pathway (GO:0035235)5.12822036
10regulation of glutamate receptor signaling pathway (GO:1900449)5.09005741
11glutamate secretion (GO:0014047)5.08320867
12pyrimidine nucleobase catabolic process (GO:0006208)4.99984549
13behavioral response to nicotine (GO:0035095)4.91672720
14glutamate receptor signaling pathway (GO:0007215)4.89002004
15neurotransmitter-gated ion channel clustering (GO:0072578)4.86162510
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.83509657
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.74407444
18regulation of synaptic vesicle exocytosis (GO:2000300)4.73245382
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.63031096
20synaptic vesicle maturation (GO:0016188)4.53944690
21exploration behavior (GO:0035640)4.52964859
22synaptic transmission, glutamatergic (GO:0035249)4.51440011
23presynaptic membrane assembly (GO:0097105)4.47603580
24gamma-aminobutyric acid signaling pathway (GO:0007214)4.42463577
25neuron-neuron synaptic transmission (GO:0007270)4.41888111
26neuronal action potential propagation (GO:0019227)4.38772109
27regulation of long-term neuronal synaptic plasticity (GO:0048169)4.32075093
28postsynaptic membrane organization (GO:0001941)4.31118466
29regulation of synaptic vesicle transport (GO:1902803)4.25518837
30positive regulation of synapse maturation (GO:0090129)4.24583944
31negative regulation of synaptic transmission, GABAergic (GO:0032229)4.18705248
32neurotransmitter secretion (GO:0007269)4.15736784
33neuron recognition (GO:0008038)4.12948599
34axon ensheathment in central nervous system (GO:0032291)4.11085765
35central nervous system myelination (GO:0022010)4.11085765
36response to histamine (GO:0034776)4.09940025
37presynaptic membrane organization (GO:0097090)4.09501675
38regulation of excitatory postsynaptic membrane potential (GO:0060079)4.04207286
39regulation of neuronal synaptic plasticity (GO:0048168)4.02826183
40G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.02240959
41nucleobase catabolic process (GO:0046113)4.01964155
42long-term synaptic potentiation (GO:0060291)4.01699776
43regulation of postsynaptic membrane potential (GO:0060078)3.85729541
44layer formation in cerebral cortex (GO:0021819)3.83563756
45gamma-aminobutyric acid transport (GO:0015812)3.83294036
46cerebellar granule cell differentiation (GO:0021707)3.81388680
47long-term memory (GO:0007616)3.80590412
48regulation of synapse structural plasticity (GO:0051823)3.75324935
49regulation of synaptic transmission, glutamatergic (GO:0051966)3.73618038
50axonal fasciculation (GO:0007413)3.71742026
51proline transport (GO:0015824)3.68089544
52regulation of synaptic plasticity (GO:0048167)3.65137099
53positive regulation of membrane potential (GO:0045838)3.63461846
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.58344335
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.57797132
56synaptic vesicle endocytosis (GO:0048488)3.57256345
57dendritic spine morphogenesis (GO:0060997)3.57086972
58cell migration in hindbrain (GO:0021535)3.57039675
59cellular potassium ion homeostasis (GO:0030007)3.55815126
60membrane depolarization during action potential (GO:0086010)3.54416197
61regulation of dendritic spine morphogenesis (GO:0061001)3.52187408
62neuronal ion channel clustering (GO:0045161)3.51364194
63behavioral fear response (GO:0001662)3.50575551
64behavioral defense response (GO:0002209)3.50575551
65positive regulation of neurotransmitter secretion (GO:0001956)3.48023034
66adult walking behavior (GO:0007628)3.47427020
67positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.46329335
68membrane repolarization (GO:0086009)3.45626942
69neurotransmitter transport (GO:0006836)3.45505689
70positive regulation of potassium ion transmembrane transport (GO:1901381)3.42829524
71transmission of nerve impulse (GO:0019226)3.42068312
72auditory behavior (GO:0031223)3.40030948
73regulation of synapse maturation (GO:0090128)3.38300696
74regulation of neurotransmitter secretion (GO:0046928)3.35857855
75fear response (GO:0042596)3.35738674
76potassium ion import (GO:0010107)3.34221061
77positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.32441606
78startle response (GO:0001964)3.31563028
79positive regulation of synapse assembly (GO:0051965)3.28413886
80establishment of mitochondrion localization (GO:0051654)3.22366245
81innervation (GO:0060384)3.21263447
82learning (GO:0007612)3.20682893
83response to auditory stimulus (GO:0010996)3.19792214
84negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.18540825
85serotonin metabolic process (GO:0042428)3.18522310
86regulation of neurotransmitter levels (GO:0001505)3.17110621
87regulation of vesicle fusion (GO:0031338)3.16633686
88regulation of dendritic spine development (GO:0060998)3.16106226
89mechanosensory behavior (GO:0007638)3.15808973
90membrane depolarization (GO:0051899)3.14982338
91behavioral response to cocaine (GO:0048148)3.13221349
92regulation of glutamate secretion (GO:0014048)3.12456935
93regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.12244747
94positive regulation of neurotransmitter transport (GO:0051590)3.11868320
95positive regulation of synaptic transmission (GO:0050806)3.11225787
96membrane repolarization during action potential (GO:0086011)3.10729861
97regulation of membrane repolarization (GO:0060306)3.09871026
98substrate-independent telencephalic tangential migration (GO:0021826)3.09870800
99substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.09870800
100G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.09271569
101regulation of neurotransmitter transport (GO:0051588)3.05555368
102regulation of synaptic transmission (GO:0050804)3.04989540
103positive regulation of dendritic spine morphogenesis (GO:0061003)3.04701387
104activation of protein kinase A activity (GO:0034199)3.03973318
105cochlea development (GO:0090102)3.02887466
106retinal ganglion cell axon guidance (GO:0031290)3.01985353
107synaptic transmission (GO:0007268)3.01883337
108cerebellar Purkinje cell differentiation (GO:0021702)3.01520865
109* synapse assembly (GO:0007416)3.01119096
110long term synaptic depression (GO:0060292)2.98705404
111positive regulation of dendritic spine development (GO:0060999)2.97082906
112dendrite morphogenesis (GO:0048813)2.97078884
113primary amino compound metabolic process (GO:1901160)2.96624073
114neuronal action potential (GO:0019228)2.96142111
115neuromuscular synaptic transmission (GO:0007274)2.95866575
116cerebral cortex radially oriented cell migration (GO:0021799)2.95336858
117regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.94331179
118regulation of female receptivity (GO:0045924)2.93167731
119positive regulation of synaptic transmission, GABAergic (GO:0032230)2.91906517
120membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.91400263
121cell differentiation in hindbrain (GO:0021533)2.88557943
122social behavior (GO:0035176)2.88118643
123intraspecies interaction between organisms (GO:0051703)2.88118643
124membrane hyperpolarization (GO:0060081)2.87832032
125neuromuscular process controlling balance (GO:0050885)2.85620536
126neurofilament cytoskeleton organization (GO:0060052)2.83718093
127central nervous system projection neuron axonogenesis (GO:0021952)2.83663600
128* synapse organization (GO:0050808)2.82472151
129potassium ion homeostasis (GO:0055075)2.81485240
130adult behavior (GO:0030534)2.79090653
131regulation of synapse assembly (GO:0051963)2.77678916
132positive regulation of action potential (GO:0045760)2.75891046

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.98090552
2GBX2_23144817_ChIP-Seq_PC3_Human4.22029782
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19841686
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11135453
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09079430
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.71887351
7REST_21632747_ChIP-Seq_MESCs_Mouse2.66987672
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62584311
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62276187
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62276187
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54762490
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50943446
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.50893051
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42187047
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.40648415
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38840614
17TAF15_26573619_Chip-Seq_HEK293_Human2.30495249
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.27598153
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23146954
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13528941
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.11971249
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10881322
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.10541715
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10063183
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.09583889
26DROSHA_22980978_ChIP-Seq_HELA_Human2.08428446
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06797698
28AR_21572438_ChIP-Seq_LNCaP_Human2.01087912
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99389617
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97334006
31* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94698059
32SMAD4_21799915_ChIP-Seq_A2780_Human1.84904924
33* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84238436
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83150193
35* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77806640
36P300_19829295_ChIP-Seq_ESCs_Human1.76773656
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62523885
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56758489
39* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55646309
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.54564049
41FUS_26573619_Chip-Seq_HEK293_Human1.54261674
42RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.53028449
43ZNF274_21170338_ChIP-Seq_K562_Hela1.52783492
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.52656056
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.49253621
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47315135
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46817130
48AR_25329375_ChIP-Seq_VCAP_Human1.45360595
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44041294
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.43003512
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.42750790
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42024351
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41319097
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40557662
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.38057255
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36325907
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35220431
58VDR_22108803_ChIP-Seq_LS180_Human1.33937667
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.33492327
60STAT3_23295773_ChIP-Seq_U87_Human1.27456383
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25565197
62* RNF2_27304074_Chip-Seq_NSC_Mouse1.22889123
63IGF1R_20145208_ChIP-Seq_DFB_Human1.22292791
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.21167484
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20751880
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20457131
67* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18597659
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17141701
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.17117056
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16441328
71* TCF4_23295773_ChIP-Seq_U87_Human1.15898981
72* AR_19668381_ChIP-Seq_PC3_Human1.15281228
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.14005894
74TP53_20018659_ChIP-ChIP_R1E_Mouse1.13748126
75* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13618776
76ER_23166858_ChIP-Seq_MCF-7_Human1.13085127
77RUNX2_22187159_ChIP-Seq_PCA_Human1.11136215
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11109225
79GATA1_26923725_Chip-Seq_HPCs_Mouse1.09882341
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09552115
81TP53_16413492_ChIP-PET_HCT116_Human1.09277667
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09045886
83TP53_18474530_ChIP-ChIP_U2OS_Human1.07825537
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07471343
85JUN_21703547_ChIP-Seq_K562_Human1.06785992
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05898136
87RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05568409
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05529716
89EWS_26573619_Chip-Seq_HEK293_Human1.04931369
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04892022
91AHR_22903824_ChIP-Seq_MCF-7_Human1.04167278
92LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04054961
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.03644006
94* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02512925
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01887166
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01887166
97BCAT_22108803_ChIP-Seq_LS180_Human1.01340893
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01197172
99RING1B_27294783_Chip-Seq_NPCs_Mouse1.00188433
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99664608
101* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98883236
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95360422
103WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95201207
104ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93092428
105SMAD3_21741376_ChIP-Seq_ESCs_Human0.92909282
106STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92878845
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92640291
108CBP_20019798_ChIP-Seq_JUKART_Human0.90781699
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90781699
110IRF1_19129219_ChIP-ChIP_H3396_Human0.90456159
111DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89837932
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89809752
113E2F1_18555785_Chip-Seq_ESCs_Mouse0.89704937
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89205726
115SOX9_26525672_Chip-Seq_HEART_Mouse0.88190010
116* KDM2B_26808549_Chip-Seq_REH_Human0.88050751

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.12603517
2MP0003880_abnormal_central_pattern5.50908707
3MP0003635_abnormal_synaptic_transmissio4.21304374
4MP0004270_analgesia3.64098284
5MP0009745_abnormal_behavioral_response3.58809541
6MP0002063_abnormal_learning/memory/cond3.49729472
7MP0001968_abnormal_touch/_nociception3.25213970
8MP0002064_seizures3.23244306
9MP0009046_muscle_twitch3.11643288
10MP0002572_abnormal_emotion/affect_behav3.00649869
11MP0002736_abnormal_nociception_after2.80882618
12MP0002734_abnormal_mechanical_nocicepti2.57900478
13MP0002272_abnormal_nervous_system2.57708491
14MP0001486_abnormal_startle_reflex2.56332590
15MP0005423_abnormal_somatic_nervous2.46665064
16MP0001501_abnormal_sleep_pattern2.46162136
17MP0001440_abnormal_grooming_behavior2.45295791
18MP0002735_abnormal_chemical_nociception2.29735234
19MP0002067_abnormal_sensory_capabilities2.13427635
20MP0003329_amyloid_beta_deposits2.10034633
21MP0009780_abnormal_chondrocyte_physiolo2.06894936
22MP0000778_abnormal_nervous_system2.00780886
23MP0002822_catalepsy2.00191942
24MP0002733_abnormal_thermal_nociception1.96707288
25MP0001970_abnormal_pain_threshold1.88422076
26MP0002184_abnormal_innervation1.88421674
27MP0002557_abnormal_social/conspecific_i1.81990980
28MP0005386_behavior/neurological_phenoty1.81021704
29MP0004924_abnormal_behavior1.81021704
30MP0001984_abnormal_olfaction1.76829055
31MP0005646_abnormal_pituitary_gland1.72816173
32MP0006276_abnormal_autonomic_nervous1.71578462
33MP0008569_lethality_at_weaning1.71341855
34MP0002653_abnormal_ependyma_morphology1.64917357
35MP0001529_abnormal_vocalization1.62198067
36MP0003879_abnormal_hair_cell1.60953385
37MP0004811_abnormal_neuron_physiology1.56086041
38MP0004858_abnormal_nervous_system1.53986268
39MP0001188_hyperpigmentation1.53599079
40MP0003123_paternal_imprinting1.53386581
41MP0003121_genomic_imprinting1.52727418
42MP0003787_abnormal_imprinting1.44360308
43MP0000955_abnormal_spinal_cord1.43503725
44MP0002909_abnormal_adrenal_gland1.41964726
45MP0002066_abnormal_motor_capabilities/c1.41017104
46MP0002102_abnormal_ear_morphology1.40535487
47MP0001905_abnormal_dopamine_level1.39096287
48MP0008877_abnormal_DNA_methylation1.37232724
49MP0002882_abnormal_neuron_morphology1.37230800
50MP0002837_dystrophic_cardiac_calcinosis1.37228888
51MP0003136_yellow_coat_color1.36568533
52MP0001502_abnormal_circadian_rhythm1.35028684
53MP0004885_abnormal_endolymph1.34554831
54MP0000569_abnormal_digit_pigmentation1.30625773
55MP0003633_abnormal_nervous_system1.26489832
56MP0005645_abnormal_hypothalamus_physiol1.23629724
57MP0004133_heterotaxia1.22263029
58MP0004142_abnormal_muscle_tone1.20302719
59MP0002152_abnormal_brain_morphology1.12572255
60MP0003631_nervous_system_phenotype1.12067378
61MP0001986_abnormal_taste_sensitivity1.09956414
62MP0003011_delayed_dark_adaptation1.05243377
63MP0003122_maternal_imprinting1.04777826
64MP0002876_abnormal_thyroid_physiology1.03843860
65MP0005551_abnormal_eye_electrophysiolog1.01179766
66MP0004742_abnormal_vestibular_system1.00845917
67MP0000604_amyloidosis0.97412104
68MP0004145_abnormal_muscle_electrophysio0.97184350
69MP0003938_abnormal_ear_development0.94960691
70MP0003890_abnormal_embryonic-extraembry0.94902303
71MP0001963_abnormal_hearing_physiology0.94654560
72MP0000049_abnormal_middle_ear0.94321688
73MP0002069_abnormal_eating/drinking_beha0.92397356
74MP0008872_abnormal_physiological_respon0.92217286
75MP0004130_abnormal_muscle_cell0.91494464
76MP0006072_abnormal_retinal_apoptosis0.91301823
77MP0008789_abnormal_olfactory_epithelium0.90822050
78MP0004215_abnormal_myocardial_fiber0.90162675
79MP0009379_abnormal_foot_pigmentation0.89803186
80MP0000751_myopathy0.89142676
81MP0002229_neurodegeneration0.89093841
82MP0005253_abnormal_eye_physiology0.87576266
83MP0010386_abnormal_urinary_bladder0.87399105
84MP0005499_abnormal_olfactory_system0.86711330
85MP0005394_taste/olfaction_phenotype0.86711330
86MP0004484_altered_response_of0.85926398
87MP0008874_decreased_physiological_sensi0.84547741
88MP0005377_hearing/vestibular/ear_phenot0.84427770
89MP0003878_abnormal_ear_physiology0.84427770
90MP0000013_abnormal_adipose_tissue0.83844119
91MP0000566_synostosis0.83633151
92MP0002751_abnormal_autonomic_nervous0.83296559
93MP0005195_abnormal_posterior_eye0.83196774
94MP0000631_abnormal_neuroendocrine_gland0.83173343
95MP0004085_abnormal_heartbeat0.83058872
96MP0003632_abnormal_nervous_system0.82367526
97MP0005535_abnormal_body_temperature0.81538598
98MP0002928_abnormal_bile_duct0.77690136
99MP0003634_abnormal_glial_cell0.75823514
100MP0002752_abnormal_somatic_nervous0.75764943
101MP0003646_muscle_fatigue0.74995746
102MP0003119_abnormal_digestive_system0.74570452
103MP0002160_abnormal_reproductive_system0.73770695
104MP0001664_abnormal_digestion0.73440065
105MP0005171_absent_coat_pigmentation0.72971738
106MP0005409_darkened_coat_color0.69761542
107MP0001177_atelectasis0.69257650
108MP0003690_abnormal_glial_cell0.67767805
109MP0000026_abnormal_inner_ear0.67074483
110MP0002234_abnormal_pharynx_morphology0.65084472
111MP0001485_abnormal_pinna_reflex0.65008478
112MP0006292_abnormal_olfactory_placode0.64010053
113MP0002638_abnormal_pupillary_reflex0.63039187
114MP0005187_abnormal_penis_morphology0.62102044
115MP0002090_abnormal_vision0.60466711
116MP0003137_abnormal_impulse_conducting0.58565637
117MP0003861_abnormal_nervous_system0.56446725
118MP0003075_altered_response_to0.56328430
119MP0001943_abnormal_respiration0.55667709
120MP0004233_abnormal_muscle_weight0.55068096
121MP0003183_abnormal_peptide_metabolism0.51091812
122MP0002082_postnatal_lethality0.50922353
123MP0010770_preweaning_lethality0.50922353
124MP0010769_abnormal_survival0.50475808
125MP0004043_abnormal_pH_regulation0.48533929
126MP0000920_abnormal_myelination0.47727892
127MP0003956_abnormal_body_size0.47643178
128MP0010768_mortality/aging0.47524499

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.35773677
2Focal seizures (HP:0007359)5.79439855
3Epileptic encephalopathy (HP:0200134)5.76404091
4Myokymia (HP:0002411)5.35068390
5Atonic seizures (HP:0010819)5.22519542
6Hyperventilation (HP:0002883)5.17440339
7Visual hallucinations (HP:0002367)5.15100723
8Febrile seizures (HP:0002373)4.72301843
9Absence seizures (HP:0002121)4.60165827
10Dialeptic seizures (HP:0011146)4.27124695
11Broad-based gait (HP:0002136)4.19309009
12Progressive cerebellar ataxia (HP:0002073)4.18382741
13Generalized tonic-clonic seizures (HP:0002069)3.95013992
14Poor eye contact (HP:0000817)3.45809576
15Gaze-evoked nystagmus (HP:0000640)3.38344505
16Drooling (HP:0002307)3.36633316
17Excessive salivation (HP:0003781)3.36633316
18Cerebral inclusion bodies (HP:0100314)3.31838368
19Diplopia (HP:0000651)3.30080713
20Abnormality of binocular vision (HP:0011514)3.30080713
21Amblyopia (HP:0000646)3.25222297
22Truncal ataxia (HP:0002078)3.20436281
23Supranuclear gaze palsy (HP:0000605)3.18440642
24Dysdiadochokinesis (HP:0002075)3.15279080
25Impaired vibration sensation in the lower limbs (HP:0002166)3.12149602
26Action tremor (HP:0002345)3.09558268
27Impaired social interactions (HP:0000735)3.05350160
28Abnormal social behavior (HP:0012433)3.05350160
29Neurofibrillary tangles (HP:0002185)3.00465404
30Hemiparesis (HP:0001269)3.00432614
31Epileptiform EEG discharges (HP:0011182)2.97242811
32Abnormal eating behavior (HP:0100738)2.96465037
33Dysmetria (HP:0001310)2.87442583
34Depression (HP:0000716)2.84221077
35Anxiety (HP:0000739)2.81822022
36Absent speech (HP:0001344)2.77209535
37Inability to walk (HP:0002540)2.72463750
38Progressive inability to walk (HP:0002505)2.72137500
39Polyphagia (HP:0002591)2.70141297
40EEG with generalized epileptiform discharges (HP:0011198)2.69470265
41Impaired smooth pursuit (HP:0007772)2.68259972
42Urinary bladder sphincter dysfunction (HP:0002839)2.66588883
43Mutism (HP:0002300)2.66094173
44Protruding tongue (HP:0010808)2.63946073
45True hermaphroditism (HP:0010459)2.54204532
46Fetal akinesia sequence (HP:0001989)2.52630731
47Nephronophthisis (HP:0000090)2.49802125
48Pancreatic fibrosis (HP:0100732)2.49614857
49Hypsarrhythmia (HP:0002521)2.49487112
50Postural instability (HP:0002172)2.46276477
51Ankle clonus (HP:0011448)2.44948241
52Abnormality of the corticospinal tract (HP:0002492)2.44809581
53Genetic anticipation (HP:0003743)2.44471861
54Insidious onset (HP:0003587)2.43899969
55Termporal pattern (HP:0011008)2.43899969
56Stereotypic behavior (HP:0000733)2.42655140
57Scanning speech (HP:0002168)2.42499835
58Gait imbalance (HP:0002141)2.42375415
59Status epilepticus (HP:0002133)2.39655379
60Abnormality of midbrain morphology (HP:0002418)2.39611216
61Molar tooth sign on MRI (HP:0002419)2.39611216
62Dysmetric saccades (HP:0000641)2.35801215
63Bradykinesia (HP:0002067)2.34754011
64Abnormality of ocular smooth pursuit (HP:0000617)2.34528575
65Abnormality of the lower motor neuron (HP:0002366)2.32095124
66Morphological abnormality of the pyramidal tract (HP:0002062)2.32012345
67Amyotrophic lateral sclerosis (HP:0007354)2.29975681
68Blue irides (HP:0000635)2.28941710
69Urinary urgency (HP:0000012)2.28763781
70Hepatoblastoma (HP:0002884)2.28669132
71Lissencephaly (HP:0001339)2.28610137
72Pancreatic cysts (HP:0001737)2.25643935
73Abnormality of salivation (HP:0100755)2.24500491
74Generalized myoclonic seizures (HP:0002123)2.20758106
75Megalencephaly (HP:0001355)2.19389646
76Type II lissencephaly (HP:0007260)2.18842370
77Impaired vibratory sensation (HP:0002495)2.17655138
78Spastic tetraplegia (HP:0002510)2.17168185
79Limb dystonia (HP:0002451)2.14952374
80Spastic gait (HP:0002064)2.14922284
81Pachygyria (HP:0001302)2.14575482
82Delusions (HP:0000746)2.13772212
83Pheochromocytoma (HP:0002666)2.13051596
84Retinal dysplasia (HP:0007973)2.10066336
85Optic nerve hypoplasia (HP:0000609)2.09136433
86Papilledema (HP:0001085)2.05941553
87Hemiplegia (HP:0002301)2.04704858
88Congenital stationary night blindness (HP:0007642)2.04587946
89Gait ataxia (HP:0002066)2.02793838
90Genital tract atresia (HP:0001827)2.01605132
91Lower limb muscle weakness (HP:0007340)2.00016156
92Vaginal atresia (HP:0000148)1.99978898
93Sleep apnea (HP:0010535)1.98285136
94Septo-optic dysplasia (HP:0100842)1.96760485
95Thickened helices (HP:0000391)1.95203050
96Congenital primary aphakia (HP:0007707)1.95076904
97Inappropriate behavior (HP:0000719)1.95010306
98Abnormality of the renal medulla (HP:0100957)1.94278446
99Torticollis (HP:0000473)1.94012119
100Medial flaring of the eyebrow (HP:0010747)1.93655514
101Intention tremor (HP:0002080)1.93393261
102Akinesia (HP:0002304)1.92562085
103Incomplete penetrance (HP:0003829)1.91601567
104Neuroendocrine neoplasm (HP:0100634)1.91253786
105Focal dystonia (HP:0004373)1.91013510
106Psychosis (HP:0000709)1.89342760
107Specific learning disability (HP:0001328)1.88671449
108Abnormality of the labia minora (HP:0012880)1.86322757
109Prolonged QT interval (HP:0001657)1.85977722
110Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85378787
111Degeneration of the lateral corticospinal tracts (HP:0002314)1.85378787
112Neuronal loss in central nervous system (HP:0002529)1.84343946
113Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83526504
114Hypoplasia of the corpus callosum (HP:0002079)1.82905100
115Generalized hypopigmentation of hair (HP:0011358)1.82441154
116Fair hair (HP:0002286)1.82159481
117Nephrogenic diabetes insipidus (HP:0009806)1.80895095
118Hyperthyroidism (HP:0000836)1.80015819
119Aplasia/Hypoplasia of the brainstem (HP:0007362)1.77482614
120Hypoplasia of the brainstem (HP:0002365)1.77482614
121Clumsiness (HP:0002312)1.75957226
122Poor coordination (HP:0002370)1.73561163
123Abnormal hair whorl (HP:0010721)1.73151591
124Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.72318513
125Narrow nasal bridge (HP:0000446)1.72043241
126Widely spaced teeth (HP:0000687)1.72012271
127Syncope (HP:0001279)1.71746784
128Agitation (HP:0000713)1.71709945
129Esotropia (HP:0000565)1.71692748
130Sclerocornea (HP:0000647)1.71582537
131Rib fusion (HP:0000902)1.71333159
132Ulnar claw (HP:0001178)1.71110470
133Ventricular fibrillation (HP:0001663)1.71026374
134Myotonia (HP:0002486)1.70393257
135Aplasia/Hypoplasia of the tibia (HP:0005772)1.70076792
136Intellectual disability, severe (HP:0010864)1.69087558
137Polydipsia (HP:0001959)1.68740216
138Abnormal drinking behavior (HP:0030082)1.68740216
139Oligodactyly (hands) (HP:0001180)1.67992274
140Abolished electroretinogram (ERG) (HP:0000550)1.67641635
141Cystic liver disease (HP:0006706)1.65544613

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.60697092
2NTRK34.21712159
3CASK4.08967819
4MARK13.37082259
5MAP3K43.28825579
6MAP3K93.15578751
7MAP2K73.07045404
8MAP3K122.57956825
9RIPK42.56161408
10DAPK22.47146774
11MINK12.42377675
12PLK22.11313947
13MAP2K42.04695565
14NTRK22.04454647
15DYRK22.04007776
16DAPK11.88857182
17CDK191.83936334
18PNCK1.68520061
19KSR11.66532032
20FRK1.60613385
21PAK61.59597641
22TNIK1.56531088
23KSR21.50263497
24GRK51.49300361
25MAPK131.42173978
26CDK51.40916310
27SIK21.39952049
28PRPF4B1.35768951
29PRKCG1.29768880
30CCNB11.27580953
31CAMKK11.25263078
32BMPR21.23171192
33NTRK11.21918066
34WNK41.15727939
35CAMK2A1.15036619
36ADRBK21.13251528
37ARAF1.09938397
38PTK2B1.07980341
39MAPK151.07896408
40OXSR11.07709076
41CAMKK21.06880929
42CAMK2B1.01453983
43FES1.00298232
44PHKG20.99065215
45PHKG10.99065215
46AKT30.98565223
47PKN10.97277268
48BMPR1B0.97242041
49NME10.92592049
50FGR0.91029462
51MAP3K130.89939883
52DYRK30.88868472
53TLK10.87124964
54PRKD30.85138637
55CDK180.83634546
56SGK2230.83621382
57SGK4940.83621382
58SGK20.83395394
59GRK10.83144268
60DYRK1A0.82688398
61CDK150.79066138
62EPHB20.78588905
63CDK140.77750371
64CSNK1G30.77702742
65MAP4K20.77368942
66STK380.77266968
67MAP3K20.76372573
68SIK30.74926990
69RAF10.73327673
70TYRO30.70473955
71SGK10.69759514
72UHMK10.69623984
73LATS20.69618472
74CSNK1A1L0.69594611
75CDK11A0.67492883
76PRKCE0.66996148
77CAMK10.65195301
78STK110.64428963
79CSNK1G20.60734687
80CSNK1G10.60042680
81MAP3K60.58560859
82CAMK1G0.58002951
83MAPK120.56895309
84RET0.56752503
85CAMK40.55829087
86DYRK1B0.54806393
87PAK30.54591653
88RPS6KA20.54352886
89INSRR0.53460803
90STK390.52187623
91CAMK2D0.51945657
92EPHA30.51936642
93MUSK0.51916491
94GRK60.51796751
95SGK30.51749157
96PDK40.51188607
97PDK30.51188607
98WNK30.49817764
99ERBB20.48832722
100FER0.46717232
101PRKCZ0.45098847
102MARK20.44362771
103CAMK1D0.44002688
104CAMK2G0.43163337
105PIK3CA0.42406822
106PRKCH0.41691030
107MAPKAPK50.41620312
108BCKDK0.41141365
109PDK10.40540743
110PINK10.40417544
111PDPK10.40220902
112BRAF0.39789020
113FGFR20.39763915
114ROCK20.39621228
115FYN0.39556899
116BCR0.39031866
117MAP3K110.38504214
118GRK70.38220449
119RPS6KA30.38127158
120ADRBK10.37916637
121ERBB30.37176895
122LMTK20.36774492
123MAP2K10.36488863
124CSNK1A10.36389289
125TNK20.36186830
126PRKG10.36023490
127DAPK30.36006064
128TAOK30.35861403
129CSNK1E0.33201014
130MAPK40.32627544
131* PRKCA0.32361672
132PRKACG0.31929578
133PRKACA0.31480765
134TRIM280.31289634
135CSNK1D0.31181373
136MAP3K10.31116105
137MAPK100.30037480
138LIMK10.29966194
139CDK30.29961918

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.49293071
2Synaptic vesicle cycle_Homo sapiens_hsa047213.26291325
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.00362010
4Long-term potentiation_Homo sapiens_hsa047202.92233776
5GABAergic synapse_Homo sapiens_hsa047272.74138277
6Circadian entrainment_Homo sapiens_hsa047132.73612076
7Glutamatergic synapse_Homo sapiens_hsa047242.71314791
8Morphine addiction_Homo sapiens_hsa050322.63443668
9Amphetamine addiction_Homo sapiens_hsa050312.59296014
10Olfactory transduction_Homo sapiens_hsa047402.55010618
11Salivary secretion_Homo sapiens_hsa049702.27558123
12Dopaminergic synapse_Homo sapiens_hsa047282.18253689
13Collecting duct acid secretion_Homo sapiens_hsa049662.16489658
14Taste transduction_Homo sapiens_hsa047422.04271626
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.98569332
16Renin secretion_Homo sapiens_hsa049241.91715268
17Long-term depression_Homo sapiens_hsa047301.88507748
18Gastric acid secretion_Homo sapiens_hsa049711.86301841
19Insulin secretion_Homo sapiens_hsa049111.85091196
20Serotonergic synapse_Homo sapiens_hsa047261.80992932
21Cholinergic synapse_Homo sapiens_hsa047251.70119152
22Calcium signaling pathway_Homo sapiens_hsa040201.69765998
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66119014
24Oxytocin signaling pathway_Homo sapiens_hsa049211.63936941
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51200727
26Cocaine addiction_Homo sapiens_hsa050301.50937562
27GnRH signaling pathway_Homo sapiens_hsa049121.34093670
28Gap junction_Homo sapiens_hsa045401.32102584
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31334564
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25203036
31Vibrio cholerae infection_Homo sapiens_hsa051101.23852267
32cAMP signaling pathway_Homo sapiens_hsa040241.23096591
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20291873
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20109633
35Axon guidance_Homo sapiens_hsa043601.18318141
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13447738
37Estrogen signaling pathway_Homo sapiens_hsa049151.08539086
38Cardiac muscle contraction_Homo sapiens_hsa042601.06907742
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06753222
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06235077
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05422107
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03060924
43Phototransduction_Homo sapiens_hsa047441.00922535
44Melanogenesis_Homo sapiens_hsa049161.00486338
45Glioma_Homo sapiens_hsa052140.99270819
46Butanoate metabolism_Homo sapiens_hsa006500.94638068
47ErbB signaling pathway_Homo sapiens_hsa040120.91733692
48Type II diabetes mellitus_Homo sapiens_hsa049300.89790726
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89228559
50Alzheimers disease_Homo sapiens_hsa050100.88879967
51Oxidative phosphorylation_Homo sapiens_hsa001900.88535253
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.86617396
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83344775
54Pancreatic secretion_Homo sapiens_hsa049720.80614198
55Oocyte meiosis_Homo sapiens_hsa041140.78352319
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75111030
57Linoleic acid metabolism_Homo sapiens_hsa005910.73415271
58Steroid biosynthesis_Homo sapiens_hsa001000.72488473
59Nitrogen metabolism_Homo sapiens_hsa009100.70102614
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69038937
61Hedgehog signaling pathway_Homo sapiens_hsa043400.68912143
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68117829
63Thyroid hormone synthesis_Homo sapiens_hsa049180.66805996
64Basal cell carcinoma_Homo sapiens_hsa052170.66101396
65Choline metabolism in cancer_Homo sapiens_hsa052310.65196832
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64487237
67MAPK signaling pathway_Homo sapiens_hsa040100.64449452
68Dorso-ventral axis formation_Homo sapiens_hsa043200.64136211
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.63413460
70Dilated cardiomyopathy_Homo sapiens_hsa054140.61531099
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59803377
72Glucagon signaling pathway_Homo sapiens_hsa049220.59671093
73Regulation of autophagy_Homo sapiens_hsa041400.58176601
74Hippo signaling pathway_Homo sapiens_hsa043900.57984261
75Ether lipid metabolism_Homo sapiens_hsa005650.57736750
76African trypanosomiasis_Homo sapiens_hsa051430.57526748
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54931742
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53332833
79VEGF signaling pathway_Homo sapiens_hsa043700.52314541
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52229262
81Ras signaling pathway_Homo sapiens_hsa040140.52096783
82Ovarian steroidogenesis_Homo sapiens_hsa049130.51229292
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50516481
84Circadian rhythm_Homo sapiens_hsa047100.49658448
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49204830
86Parkinsons disease_Homo sapiens_hsa050120.48837444
87Rheumatoid arthritis_Homo sapiens_hsa053230.46680694
88Rap1 signaling pathway_Homo sapiens_hsa040150.45977827
89Alcoholism_Homo sapiens_hsa050340.44423940
90Type I diabetes mellitus_Homo sapiens_hsa049400.43755645
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.42600914
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42587292
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.42287573
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42031617
95Inositol phosphate metabolism_Homo sapiens_hsa005620.40875423
96Wnt signaling pathway_Homo sapiens_hsa043100.40121111
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40080247
98Protein export_Homo sapiens_hsa030600.39651991
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.39309316
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37699987
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37680031
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37031071
103Huntingtons disease_Homo sapiens_hsa050160.36818990
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34742748
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34209136
106Glycerolipid metabolism_Homo sapiens_hsa005610.32988875
107Bile secretion_Homo sapiens_hsa049760.32161465
108Histidine metabolism_Homo sapiens_hsa003400.31933723
109Prion diseases_Homo sapiens_hsa050200.31816346
110Renal cell carcinoma_Homo sapiens_hsa052110.31735213
111Tryptophan metabolism_Homo sapiens_hsa003800.31547531
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28204319
113mTOR signaling pathway_Homo sapiens_hsa041500.27964901
114Insulin signaling pathway_Homo sapiens_hsa049100.27303391
115beta-Alanine metabolism_Homo sapiens_hsa004100.25649031
116Endometrial cancer_Homo sapiens_hsa052130.25634905
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25265126
118Fatty acid biosynthesis_Homo sapiens_hsa000610.24416766
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24281424
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23788755
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22898522
122Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22377241
123Phagosome_Homo sapiens_hsa041450.21847817

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