GPM6B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a membrane glycoprotein that belongs to the proteolipid protein family. Proteolipid protein family members are expressed in most brain regions and are thought to be involved in cellular housekeeping functions such as membrane trafficking and cell-to-cell communication. This protein may also be involved in osteoblast differentiation. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes Y and 22. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.28122971
2central nervous system myelination (GO:0022010)6.28122971
3locomotory exploration behavior (GO:0035641)4.74090494
4synaptic vesicle maturation (GO:0016188)4.69075567
5L-amino acid import (GO:0043092)4.59782261
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.56947397
7neuronal action potential propagation (GO:0019227)4.50560216
8neuron cell-cell adhesion (GO:0007158)4.38786087
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.35041869
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.33186382
11vocalization behavior (GO:0071625)4.23944027
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.22157997
13synaptic vesicle exocytosis (GO:0016079)4.21068950
14glutamate secretion (GO:0014047)4.14841254
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.09571644
16regulation of synaptic vesicle exocytosis (GO:2000300)3.99386663
17glutamate receptor signaling pathway (GO:0007215)3.87869814
18presynaptic membrane organization (GO:0097090)3.86426334
19regulation of glutamate receptor signaling pathway (GO:1900449)3.82187391
20protein localization to synapse (GO:0035418)3.81916408
21regulation of neuronal synaptic plasticity (GO:0048168)3.80246314
22cellular potassium ion homeostasis (GO:0030007)3.79964342
23dendritic spine morphogenesis (GO:0060997)3.77238327
24synaptic transmission, glutamatergic (GO:0035249)3.74682965
25neurotransmitter-gated ion channel clustering (GO:0072578)3.73277032
26presynaptic membrane assembly (GO:0097105)3.72390844
27gamma-aminobutyric acid transport (GO:0015812)3.68858053
28cerebellar granule cell differentiation (GO:0021707)3.68710479
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.67499044
30amino acid import (GO:0043090)3.65299936
31neuron-neuron synaptic transmission (GO:0007270)3.62331443
32layer formation in cerebral cortex (GO:0021819)3.59663370
33regulation of synapse structural plasticity (GO:0051823)3.59588753
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.57706379
35myelination (GO:0042552)3.53606430
36transmission of nerve impulse (GO:0019226)3.53169837
37exploration behavior (GO:0035640)3.50566742
38ensheathment of neurons (GO:0007272)3.49113787
39axon ensheathment (GO:0008366)3.49113787
40neuron recognition (GO:0008038)3.48332408
41auditory behavior (GO:0031223)3.48039583
42regulation of synaptic vesicle transport (GO:1902803)3.47460491
43long-term synaptic potentiation (GO:0060291)3.42012109
44long-term memory (GO:0007616)3.39995202
45pyrimidine nucleobase catabolic process (GO:0006208)3.38218681
46negative regulation of synaptic transmission, GABAergic (GO:0032229)3.37783899
47cellular sodium ion homeostasis (GO:0006883)3.37652546
48gamma-aminobutyric acid signaling pathway (GO:0007214)3.37480703
49adult walking behavior (GO:0007628)3.36493229
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.34496932
51synaptic vesicle docking involved in exocytosis (GO:0016081)3.34147636
52neurotransmitter secretion (GO:0007269)3.32284092
53positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.28291810
54regulation of excitatory postsynaptic membrane potential (GO:0060079)3.27522235
55positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.27204505
56long-chain fatty acid biosynthetic process (GO:0042759)3.26810926
57axonal fasciculation (GO:0007413)3.26540215
58regulation of dendritic spine morphogenesis (GO:0061001)3.25812801
59sodium ion export (GO:0071436)3.25599909
60response to auditory stimulus (GO:0010996)3.25260871
61dendrite morphogenesis (GO:0048813)3.22800751
62mechanosensory behavior (GO:0007638)3.22647552
63oligodendrocyte differentiation (GO:0048709)3.22603129
64astrocyte differentiation (GO:0048708)3.21188541
65synaptic vesicle endocytosis (GO:0048488)3.17909834
66neurotransmitter uptake (GO:0001504)3.15435912
67regulation of synaptic plasticity (GO:0048167)3.15294430
68fatty acid elongation (GO:0030497)3.14698598
69regulation of synaptic transmission, glutamatergic (GO:0051966)3.14514711
70positive regulation of synapse assembly (GO:0051965)3.13252114
71G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.12518805
72establishment of mitochondrion localization (GO:0051654)3.11235229
73potassium ion import (GO:0010107)3.09295948
74regulation of postsynaptic membrane potential (GO:0060078)3.08487991
75cell communication by electrical coupling (GO:0010644)3.07967373
76regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.07395653
77postsynaptic membrane organization (GO:0001941)3.07231899
78neuromuscular process controlling balance (GO:0050885)3.06861411
79glycine transport (GO:0015816)3.05939481
80regulation of respiratory system process (GO:0044065)3.05470658
81positive regulation of membrane potential (GO:0045838)3.02990134
82regulation of voltage-gated calcium channel activity (GO:1901385)3.02832478
83C4-dicarboxylate transport (GO:0015740)3.00643284
84neurotransmitter transport (GO:0006836)2.99920538
85regulation of cardiac muscle cell contraction (GO:0086004)2.99632569
86regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.99074342
87negative regulation of neurotransmitter secretion (GO:0046929)2.98059916
88neuronal ion channel clustering (GO:0045161)2.97812762
89astrocyte development (GO:0014002)2.97528502
90* regulation of neurotransmitter transport (GO:0051588)2.96641367
91regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.96606018
92cerebral cortex radially oriented cell migration (GO:0021799)2.95654099
93negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.93249263
94response to methylmercury (GO:0051597)2.92903177
95regulation of dendritic spine development (GO:0060998)2.90846138
96startle response (GO:0001964)2.89128670
97negative regulation of cytosolic calcium ion concentration (GO:0051481)2.87965713
98membrane hyperpolarization (GO:0060081)2.87489972
99prepulse inhibition (GO:0060134)2.87019943
100regulation of neurotransmitter secretion (GO:0046928)2.86352551
101positive regulation of potassium ion transmembrane transport (GO:1901381)2.84509571
102membrane assembly (GO:0071709)2.84081344
103positive regulation of dendritic spine development (GO:0060999)2.80944487
104potassium ion homeostasis (GO:0055075)2.79933980
105nerve growth factor signaling pathway (GO:0038180)2.79180128
106acidic amino acid transport (GO:0015800)2.78600909
107myelin maintenance (GO:0043217)2.76299908
108synapse assembly (GO:0007416)2.75589557
109cellular response to cholesterol (GO:0071397)2.75282651
110regulation of neurotransmitter levels (GO:0001505)2.75180512
111learning (GO:0007612)2.73877515
112nucleobase catabolic process (GO:0046113)2.71367299
113L-glutamate transport (GO:0015813)2.71293148
114neuromuscular synaptic transmission (GO:0007274)2.71017811
115regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.70806853
116synapse organization (GO:0050808)2.70744573
117dendritic spine organization (GO:0097061)2.70642714
118positive regulation of synaptic transmission (GO:0050806)2.67226585
119regulation of vesicle fusion (GO:0031338)2.66173281
120membrane depolarization (GO:0051899)2.66149365
121positive regulation of synaptic transmission, GABAergic (GO:0032230)2.63912315

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EZH2_22144423_ChIP-Seq_EOC_Human4.02132498
2GBX2_23144817_ChIP-Seq_PC3_Human3.48132312
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09685028
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05777437
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96707842
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69208757
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69208757
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56561605
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55590936
10* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52194045
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50692594
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48017942
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.46029978
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42339882
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.38529295
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.27424119
17DROSHA_22980978_ChIP-Seq_HELA_Human2.25660019
18REST_21632747_ChIP-Seq_MESCs_Mouse2.23195329
19AR_21572438_ChIP-Seq_LNCaP_Human2.23161376
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.19462146
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.19139244
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18593848
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89054591
24REST_18959480_ChIP-ChIP_MESCs_Mouse1.79220956
25* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76630324
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74454159
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67341447
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67291870
29TAF15_26573619_Chip-Seq_HEK293_Human1.67006707
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62765742
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61121478
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60495215
33* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58123922
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53269356
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52043135
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51657226
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50292955
38SMAD4_21799915_ChIP-Seq_A2780_Human1.49940264
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49739942
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.45417670
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44897849
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.44112749
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.41227055
44P300_19829295_ChIP-Seq_ESCs_Human1.40619250
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.39630491
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39564537
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38037278
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37905884
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.32881670
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32325535
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29397341
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.28719224
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26874644
54SOX9_26525672_Chip-Seq_HEART_Mouse1.25587009
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24631637
56* STAT3_23295773_ChIP-Seq_U87_Human1.24375030
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23746289
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.23484831
59* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21111498
60WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20489393
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.19914572
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18118784
63TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18049722
64AR_25329375_ChIP-Seq_VCAP_Human1.16289891
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.16070160
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15992821
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15852362
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.13330791
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11774782
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11621149
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11019324
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10583521
73ER_23166858_ChIP-Seq_MCF-7_Human1.10514750
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10392819
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10392819
76TP53_16413492_ChIP-PET_HCT116_Human1.10026145
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09457259
78* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09238461
79TCF4_23295773_ChIP-Seq_U87_Human1.08740836
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08562724
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07684912
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.07034578
83* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06823395
84AR_19668381_ChIP-Seq_PC3_Human1.05170830
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04792885
86EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04583500
87AHR_22903824_ChIP-Seq_MCF-7_Human1.04115863
88FUS_26573619_Chip-Seq_HEK293_Human1.03986530
89SMAD_19615063_ChIP-ChIP_OVARY_Human1.03472991
90VDR_22108803_ChIP-Seq_LS180_Human1.03314243
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02914303
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02291216
93ZNF274_21170338_ChIP-Seq_K562_Hela1.01587480
94RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01553203
95TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00986543
96WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00971212
97JUN_21703547_ChIP-Seq_K562_Human1.00518126
98OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00137681
99TAL1_26923725_Chip-Seq_HPCs_Mouse0.99831269
100TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99431711
101DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97917591
102YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97777449
103RUNX2_22187159_ChIP-Seq_PCA_Human0.97623057
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96733610
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96412101
106KDM2B_26808549_Chip-Seq_REH_Human0.95986740
107RNF2_27304074_Chip-Seq_NSC_Mouse0.95707989
108RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94847913
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94200674
110NANOG_18555785_Chip-Seq_ESCs_Mouse0.92239597
111TP53_18474530_ChIP-ChIP_U2OS_Human0.91788574
112IGF1R_20145208_ChIP-Seq_DFB_Human0.90997067
113* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90529180
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.89589561
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89551494
116RXR_22108803_ChIP-Seq_LS180_Human0.89261397
117SMAD4_21741376_ChIP-Seq_EPCs_Human0.89123902
118STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.88814258
119EP300_21415370_ChIP-Seq_HL-1_Mouse0.87888474
120* SMAD4_21741376_ChIP-Seq_HESCs_Human0.87688466
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87116907

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.51699624
2MP0003880_abnormal_central_pattern4.67721070
3MP0004270_analgesia3.72786680
4MP0003635_abnormal_synaptic_transmissio3.69252892
5MP0009745_abnormal_behavioral_response3.13823232
6MP0002064_seizures3.07879089
7MP0002063_abnormal_learning/memory/cond2.98735957
8MP0001486_abnormal_startle_reflex2.91165362
9MP0009046_muscle_twitch2.88405862
10MP0005423_abnormal_somatic_nervous2.87507961
11MP0002272_abnormal_nervous_system2.78347514
12MP0000920_abnormal_myelination2.65833571
13MP0002572_abnormal_emotion/affect_behav2.57569695
14MP0003329_amyloid_beta_deposits2.53048636
15MP0001968_abnormal_touch/_nociception2.49486868
16MP0002734_abnormal_mechanical_nocicepti2.43631716
17MP0004885_abnormal_endolymph2.41602157
18MP0002822_catalepsy2.40519239
19MP0000778_abnormal_nervous_system2.23907729
20MP0003690_abnormal_glial_cell2.15145461
21MP0008569_lethality_at_weaning2.08217129
22MP0002638_abnormal_pupillary_reflex2.05432067
23MP0001440_abnormal_grooming_behavior2.02525707
24MP0002736_abnormal_nociception_after2.00909061
25MP0002067_abnormal_sensory_capabilities1.93982294
26MP0001970_abnormal_pain_threshold1.83449076
27MP0001501_abnormal_sleep_pattern1.78745063
28MP0001529_abnormal_vocalization1.78590623
29MP0002733_abnormal_thermal_nociception1.76720719
30MP0004858_abnormal_nervous_system1.76098980
31MP0004742_abnormal_vestibular_system1.69154822
32MP0002735_abnormal_chemical_nociception1.67697586
33MP0002653_abnormal_ependyma_morphology1.67577634
34MP0003633_abnormal_nervous_system1.67052801
35MP0003634_abnormal_glial_cell1.66754543
36MP0000955_abnormal_spinal_cord1.65388636
37MP0001905_abnormal_dopamine_level1.63796350
38MP0004142_abnormal_muscle_tone1.63048698
39MP0009780_abnormal_chondrocyte_physiolo1.62083521
40MP0005386_behavior/neurological_phenoty1.61103457
41MP0004924_abnormal_behavior1.61103457
42MP0002557_abnormal_social/conspecific_i1.59715192
43MP0005646_abnormal_pituitary_gland1.54884526
44MP0003631_nervous_system_phenotype1.54094314
45MP0002882_abnormal_neuron_morphology1.53079291
46MP0002184_abnormal_innervation1.51851803
47MP0002066_abnormal_motor_capabilities/c1.47732292
48MP0001485_abnormal_pinna_reflex1.44086838
49MP0003632_abnormal_nervous_system1.41890718
50MP0004811_abnormal_neuron_physiology1.41523592
51MP0005171_absent_coat_pigmentation1.39681082
52MP0002229_neurodegeneration1.30239165
53MP0001984_abnormal_olfaction1.28215534
54MP0005409_darkened_coat_color1.27677253
55MP0005551_abnormal_eye_electrophysiolog1.26094860
56MP0001502_abnormal_circadian_rhythm1.22801188
57MP0000604_amyloidosis1.19609393
58MP0002152_abnormal_brain_morphology1.18565797
59MP0003136_yellow_coat_color1.18024146
60MP0003122_maternal_imprinting1.15905363
61MP0004043_abnormal_pH_regulation1.15827971
62MP0005645_abnormal_hypothalamus_physiol1.14502220
63MP0001963_abnormal_hearing_physiology1.08884918
64MP0001177_atelectasis1.08880446
65MP0004145_abnormal_muscle_electrophysio1.06292465
66MP0000566_synostosis1.06284559
67MP0005248_abnormal_Harderian_gland1.02121029
68MP0000569_abnormal_digit_pigmentation0.98790322
69MP0002909_abnormal_adrenal_gland0.98383058
70MP0003075_altered_response_to0.95276092
71MP0002752_abnormal_somatic_nervous0.94236110
72MP0003879_abnormal_hair_cell0.92847459
73MP0006292_abnormal_olfactory_placode0.92595235
74MP0005187_abnormal_penis_morphology0.91892339
75MP0001299_abnormal_eye_distance/0.91294427
76MP0005623_abnormal_meninges_morphology0.90497262
77MP0006276_abnormal_autonomic_nervous0.89822264
78MP0003950_abnormal_plasma_membrane0.88063090
79MP0001188_hyperpigmentation0.87733428
80MP0008789_abnormal_olfactory_epithelium0.86117083
81MP0005410_abnormal_fertilization0.84374650
82MP0004133_heterotaxia0.84005063
83MP0002090_abnormal_vision0.82653732
84MP0000631_abnormal_neuroendocrine_gland0.80193093
85MP0005174_abnormal_tail_pigmentation0.78335773
86MP0000579_abnormal_nail_morphology0.76558108
87MP0002069_abnormal_eating/drinking_beha0.75965543
88MP0004147_increased_porphyrin_level0.75325632
89MP0001346_abnormal_lacrimal_gland0.73434279
90MP0003137_abnormal_impulse_conducting0.72558502
91MP0000026_abnormal_inner_ear0.71496944
92MP0008872_abnormal_physiological_respon0.71102490
93MP0000751_myopathy0.70584524
94MP0008877_abnormal_DNA_methylation0.70538754
95MP0008874_decreased_physiological_sensi0.70080640
96MP0002751_abnormal_autonomic_nervous0.69977192
97MP0000013_abnormal_adipose_tissue0.68915395
98MP0000647_abnormal_sebaceous_gland0.68787639
99MP0001986_abnormal_taste_sensitivity0.68761179
100MP0004085_abnormal_heartbeat0.68707290
101MP0003119_abnormal_digestive_system0.68187224
102MP0002249_abnormal_larynx_morphology0.66298376
103MP0005167_abnormal_blood-brain_barrier0.65388357
104MP0003121_genomic_imprinting0.65183590
105MP0000049_abnormal_middle_ear0.64609002
106MP0002095_abnormal_skin_pigmentation0.64091433
107MP0004134_abnormal_chest_morphology0.63547562
108MP0003787_abnormal_imprinting0.63532948
109MP0003861_abnormal_nervous_system0.62959608
110MP0001943_abnormal_respiration0.62860967
111MP0005253_abnormal_eye_physiology0.62727603
112MP0005499_abnormal_olfactory_system0.62249575
113MP0005394_taste/olfaction_phenotype0.62249575
114MP0003011_delayed_dark_adaptation0.61468452
115MP0005195_abnormal_posterior_eye0.59691519
116MP0006072_abnormal_retinal_apoptosis0.59518169
117MP0003938_abnormal_ear_development0.59472999
118MP0001664_abnormal_digestion0.56812814
119MP0000747_muscle_weakness0.56327925
120MP0005535_abnormal_body_temperature0.54490135
121MP0010678_abnormal_skin_adnexa0.52450300
122MP0004215_abnormal_myocardial_fiber0.50098173
123MP0010769_abnormal_survival0.48523694
124MP0000462_abnormal_digestive_system0.48204092

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.06515597
2Myokymia (HP:0002411)5.92152664
3Neurofibrillary tangles (HP:0002185)5.04779782
4Focal seizures (HP:0007359)4.39654120
5Action tremor (HP:0002345)4.29306460
6Degeneration of the lateral corticospinal tracts (HP:0002314)4.23519331
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.23519331
8Supranuclear gaze palsy (HP:0000605)4.12354874
9Cerebral inclusion bodies (HP:0100314)4.11077987
10Epileptic encephalopathy (HP:0200134)3.96259941
11Abnormality of the corticospinal tract (HP:0002492)3.92168272
12Ankle clonus (HP:0011448)3.88245129
13Termporal pattern (HP:0011008)3.70363048
14Insidious onset (HP:0003587)3.70363048
15Progressive cerebellar ataxia (HP:0002073)3.66026345
16Megalencephaly (HP:0001355)3.65983637
17Dysmetria (HP:0001310)3.64061213
18Scanning speech (HP:0002168)3.47864556
19Visual hallucinations (HP:0002367)3.46955979
20Intention tremor (HP:0002080)3.40590536
21Polyphagia (HP:0002591)3.35127680
22Broad-based gait (HP:0002136)3.31222624
23Spastic gait (HP:0002064)3.29901855
24Dysdiadochokinesis (HP:0002075)3.29742832
25Peripheral hypomyelination (HP:0007182)3.29465932
26Atonic seizures (HP:0010819)3.09051917
27Hyperventilation (HP:0002883)3.07521842
28Hemiparesis (HP:0001269)2.98748635
29Gaze-evoked nystagmus (HP:0000640)2.94424097
30Urinary urgency (HP:0000012)2.92672666
31Generalized tonic-clonic seizures (HP:0002069)2.90902458
32Aplasia involving bones of the extremities (HP:0009825)2.90730171
33Aplasia involving bones of the upper limbs (HP:0009823)2.90730171
34Aplasia of the phalanges of the hand (HP:0009802)2.90730171
35Dialeptic seizures (HP:0011146)2.87744288
36Truncal ataxia (HP:0002078)2.87303771
37Abnormality of binocular vision (HP:0011514)2.85860736
38Diplopia (HP:0000651)2.85860736
39Absence seizures (HP:0002121)2.85477945
40Gait imbalance (HP:0002141)2.79105906
41Urinary bladder sphincter dysfunction (HP:0002839)2.74639420
42Impaired vibration sensation in the lower limbs (HP:0002166)2.74156489
43Poor eye contact (HP:0000817)2.71129792
44Onion bulb formation (HP:0003383)2.66868274
45Febrile seizures (HP:0002373)2.66698429
46Anxiety (HP:0000739)2.62333897
47Lower limb muscle weakness (HP:0007340)2.61255567
48Retinal dysplasia (HP:0007973)2.60010846
49Depression (HP:0000716)2.54985115
50Clumsiness (HP:0002312)2.49569059
51Abnormal eating behavior (HP:0100738)2.48303951
52Pheochromocytoma (HP:0002666)2.45315170
53Postural instability (HP:0002172)2.44809077
54Excessive salivation (HP:0003781)2.43361795
55Drooling (HP:0002307)2.43361795
56Abnormal social behavior (HP:0012433)2.32961138
57Impaired social interactions (HP:0000735)2.32961138
58Thickened helices (HP:0000391)2.30746329
59Congenital primary aphakia (HP:0007707)2.28248131
60Clonus (HP:0002169)2.27186164
61Mutism (HP:0002300)2.26551401
62Heterochromia iridis (HP:0001100)2.26283824
63Status epilepticus (HP:0002133)2.21095006
64Hemiplegia (HP:0002301)2.20290655
65Abnormality of the diencephalon (HP:0010662)2.18975853
66Amyotrophic lateral sclerosis (HP:0007354)2.17350280
67Specific learning disability (HP:0001328)2.16867947
68Medial flaring of the eyebrow (HP:0010747)2.15470458
69Abnormal auditory evoked potentials (HP:0006958)2.15418093
70Split foot (HP:0001839)2.12311959
71Broad foot (HP:0001769)2.11975355
72Torticollis (HP:0000473)2.09355593
73Progressive inability to walk (HP:0002505)2.09130138
74Neuronal loss in central nervous system (HP:0002529)2.06507004
75Nephrogenic diabetes insipidus (HP:0009806)2.05690686
76Genital tract atresia (HP:0001827)2.05410876
77True hermaphroditism (HP:0010459)2.03621912
78Alacrima (HP:0000522)2.03207655
79Abnormality of saccadic eye movements (HP:0000570)2.02940146
80Increased circulating renin level (HP:0000848)2.01890275
81Neuroendocrine neoplasm (HP:0100634)2.01890109
82Genetic anticipation (HP:0003743)2.00860251
83Absent speech (HP:0001344)2.00267840
84Stereotypic behavior (HP:0000733)2.00148684
85Cerebral hypomyelination (HP:0006808)1.99887177
86Amblyopia (HP:0000646)1.99236377
87Vaginal atresia (HP:0000148)1.98414731
88Septo-optic dysplasia (HP:0100842)1.97997315
89Gait ataxia (HP:0002066)1.97444313
90Epileptiform EEG discharges (HP:0011182)1.94743888
91Postural tremor (HP:0002174)1.94133981
92Spastic tetraparesis (HP:0001285)1.94036640
93Oligodactyly (hands) (HP:0001180)1.93798995
94Abnormality of the lower motor neuron (HP:0002366)1.93301681
95Generalized myoclonic seizures (HP:0002123)1.92113439
96Impaired vibratory sensation (HP:0002495)1.91569842
97Abnormality of the labia minora (HP:0012880)1.91459322
98White forelock (HP:0002211)1.91298232
99Limb dystonia (HP:0002451)1.90921540
100Focal dystonia (HP:0004373)1.90400129
101Blue irides (HP:0000635)1.90218462
102Hypoplasia of the corpus callosum (HP:0002079)1.89789097
103Cutaneous finger syndactyly (HP:0010554)1.89247087
104EEG with generalized epileptiform discharges (HP:0011198)1.87769480
105Impaired smooth pursuit (HP:0007772)1.86797443
106Synostosis involving the elbow (HP:0003938)1.86304222
107Humeroradial synostosis (HP:0003041)1.86304222
108Hammertoe (HP:0001765)1.85427190
109Morphological abnormality of the pyramidal tract (HP:0002062)1.84355234
110Hepatoblastoma (HP:0002884)1.84188331
111Sleep apnea (HP:0010535)1.83392937
112Hypsarrhythmia (HP:0002521)1.82343717
113Patchy hypopigmentation of hair (HP:0011365)1.82130180
114Optic nerve hypoplasia (HP:0000609)1.80131147
115Bowel incontinence (HP:0002607)1.79694518
116Bradykinesia (HP:0002067)1.79457347
117Hyperglycinemia (HP:0002154)1.79076674
118Papilledema (HP:0001085)1.77952948
119Coronal craniosynostosis (HP:0004440)1.77691999
120Slow saccadic eye movements (HP:0000514)1.76897378
121Metabolic alkalosis (HP:0200114)1.76722025
122Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.74694416
123Rigidity (HP:0002063)1.74658075
124Psychosis (HP:0000709)1.74403217
125Anteriorly placed anus (HP:0001545)1.73766617
126Sensory axonal neuropathy (HP:0003390)1.73306639
127Tetraplegia (HP:0002445)1.72833855
128Abnormality of salivation (HP:0100755)1.72709129
129Bronchomalacia (HP:0002780)1.72182400
130Decreased lacrimation (HP:0000633)1.72159332
131Morphological abnormality of the inner ear (HP:0011390)1.71416854
132CNS hypomyelination (HP:0003429)1.69714875
133Cutaneous syndactyly (HP:0012725)1.67584673
134Abnormality of glycine metabolism (HP:0010895)1.65778967
135Abnormality of serine family amino acid metabolism (HP:0010894)1.65778967
136Poor coordination (HP:0002370)1.64260885

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.29218115
2NTRK33.23832593
3MARK12.94721629
4STK392.67345316
5CASK2.49684383
6MAP3K92.46666740
7OXSR12.36114412
8NTRK22.24926811
9PAK62.10032192
10MAP3K42.02855022
11DAPK21.97706740
12NTRK11.96490230
13MINK11.89783010
14PRKD31.79589467
15MAPKAPK51.75009261
16CDK191.74308615
17PNCK1.71359131
18KSR21.70934292
19MAP2K71.69277366
20TNIK1.62051554
21SGK4941.58829717
22SGK2231.58829717
23PRPF4B1.52451121
24CDK51.52064293
25UHMK11.50681292
26PHKG21.46094724
27PHKG11.46094724
28RIPK41.45569530
29TYRO31.43548470
30PKN11.39855368
31FGFR21.39616410
32CAMK2B1.34699609
33EPHA31.33073406
34EPHB11.28056536
35CAMKK11.27959805
36PLK21.27068660
37MAPK131.23795206
38WNK11.22795493
39CAMK2A1.13254291
40KSR11.11380286
41BCR1.07091707
42MAP2K41.06712829
43WNK31.03375341
44ROCK21.03241863
45CAMKK21.02866025
46CDK150.98548191
47CDK140.97919420
48CDK180.96858802
49CSNK1G20.96462757
50FGR0.95397416
51PINK10.95366132
52MAP3K20.95154586
53FES0.94442326
54PAK30.94382960
55NEK60.94325044
56PRKCG0.93566776
57CAMK2D0.92936549
58LMTK20.91817337
59GRK50.90094775
60WNK40.89160657
61ARAF0.87956339
62MARK20.86925627
63CDK11A0.85903431
64MAP3K130.84704685
65BMPR20.82209569
66MUSK0.81614163
67CAMK2G0.81103414
68MAP4K20.77754905
69BMPR1B0.77326410
70STK110.76726803
71PRKCH0.74757777
72MAPK150.73918663
73CCNB10.72628328
74DYRK1A0.72438578
75LIMK10.72196688
76PRKCE0.72021662
77LATS20.71276682
78ERBB20.70624681
79SGK10.69875095
80PDPK10.68550981
81MKNK20.67927221
82CSNK1A1L0.67840010
83CAMK10.67178720
84PTK2B0.66815272
85CSNK1G30.65706790
86ERBB30.65395182
87CAMK1G0.64540393
88TSSK60.63893875
89SIK20.63225089
90EPHB20.62500381
91SGK20.61332806
92RET0.60830313
93FYN0.58210910
94DAPK10.58049317
95STK380.57990847
96PDK10.55930436
97DMPK0.53354172
98PRKD10.51174384
99SGK30.49999329
100PBK0.49656685
101BCKDK0.49619844
102CDK30.48318467
103ROCK10.47446320
104CSNK1D0.46733321
105MAPK120.46043282
106RPS6KA30.45693843
107PRKCQ0.44778933
108MAP3K120.44299192
109CSNK1G10.44272566
110MAPK100.43810727
111MOS0.43207310
112PRKG10.42945713
113PRKCZ0.42225193
114DYRK20.41907947
115RAF10.41529444
116MET0.41275588
117CAMK40.39510892
118BRSK10.38354786
119CSNK1A10.38246404
120DDR20.36496532
121WEE10.36078962
122ALK0.35817240
123STK38L0.33986797
124PRKACA0.33752821
125TRIM280.33320092

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.21535949
2Nitrogen metabolism_Homo sapiens_hsa009102.73692428
3Glutamatergic synapse_Homo sapiens_hsa047242.72129164
4GABAergic synapse_Homo sapiens_hsa047272.67099164
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53808105
6Circadian entrainment_Homo sapiens_hsa047132.48772451
7Morphine addiction_Homo sapiens_hsa050322.41119079
8Synaptic vesicle cycle_Homo sapiens_hsa047212.38787244
9Long-term potentiation_Homo sapiens_hsa047202.27914093
10Olfactory transduction_Homo sapiens_hsa047402.19707412
11Amphetamine addiction_Homo sapiens_hsa050312.11347976
12Salivary secretion_Homo sapiens_hsa049702.09828851
13Dopaminergic synapse_Homo sapiens_hsa047281.94295556
14Gastric acid secretion_Homo sapiens_hsa049711.90891431
15Long-term depression_Homo sapiens_hsa047301.86571372
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.80894389
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78119608
18Cholinergic synapse_Homo sapiens_hsa047251.71985447
19Serotonergic synapse_Homo sapiens_hsa047261.67547294
20Cocaine addiction_Homo sapiens_hsa050301.64801817
21Renin secretion_Homo sapiens_hsa049241.61936442
22Insulin secretion_Homo sapiens_hsa049111.61456426
23Taste transduction_Homo sapiens_hsa047421.54131438
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48793418
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46700500
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43093119
27Axon guidance_Homo sapiens_hsa043601.41607197
28Oxytocin signaling pathway_Homo sapiens_hsa049211.38094305
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.35068966
30Calcium signaling pathway_Homo sapiens_hsa040201.33661922
31Gap junction_Homo sapiens_hsa045401.32600076
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27136345
33Steroid biosynthesis_Homo sapiens_hsa001001.25716432
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23570329
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21492125
36cAMP signaling pathway_Homo sapiens_hsa040241.18108982
37Fatty acid elongation_Homo sapiens_hsa000621.17108742
38GnRH signaling pathway_Homo sapiens_hsa049121.15167187
39Collecting duct acid secretion_Homo sapiens_hsa049661.11025902
40beta-Alanine metabolism_Homo sapiens_hsa004101.08893344
41Ether lipid metabolism_Homo sapiens_hsa005651.07899768
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06990298
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04312385
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99778410
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98608296
46Propanoate metabolism_Homo sapiens_hsa006400.98037707
47Dorso-ventral axis formation_Homo sapiens_hsa043200.97142646
48Pancreatic secretion_Homo sapiens_hsa049720.96372575
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96191266
50Melanogenesis_Homo sapiens_hsa049160.96108859
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.95837651
52Arginine and proline metabolism_Homo sapiens_hsa003300.94631628
53ErbB signaling pathway_Homo sapiens_hsa040120.92886641
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.92780686
55Estrogen signaling pathway_Homo sapiens_hsa049150.91242590
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91172021
57Fatty acid metabolism_Homo sapiens_hsa012120.90017156
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89497199
59Cardiac muscle contraction_Homo sapiens_hsa042600.88770880
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87868158
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87819478
62Glioma_Homo sapiens_hsa052140.87786168
63Phototransduction_Homo sapiens_hsa047440.86853224
64Histidine metabolism_Homo sapiens_hsa003400.86673354
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.82073304
66Hippo signaling pathway_Homo sapiens_hsa043900.81525895
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80689188
68Fatty acid biosynthesis_Homo sapiens_hsa000610.78153746
69Circadian rhythm_Homo sapiens_hsa047100.76558124
70Renal cell carcinoma_Homo sapiens_hsa052110.75146449
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74506307
72Choline metabolism in cancer_Homo sapiens_hsa052310.73497343
73Vibrio cholerae infection_Homo sapiens_hsa051100.71273472
74Type II diabetes mellitus_Homo sapiens_hsa049300.71181648
75Ras signaling pathway_Homo sapiens_hsa040140.69048696
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68626040
77Thyroid hormone synthesis_Homo sapiens_hsa049180.68047109
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67638593
79Butanoate metabolism_Homo sapiens_hsa006500.65762956
80Dilated cardiomyopathy_Homo sapiens_hsa054140.65405202
81Basal cell carcinoma_Homo sapiens_hsa052170.64795801
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64434113
83MAPK signaling pathway_Homo sapiens_hsa040100.61768141
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61507674
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58423494
86Rap1 signaling pathway_Homo sapiens_hsa040150.58346080
87Folate biosynthesis_Homo sapiens_hsa007900.57321260
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55942786
89Endocytosis_Homo sapiens_hsa041440.52933464
90Bile secretion_Homo sapiens_hsa049760.52674302
91Alzheimers disease_Homo sapiens_hsa050100.49490442
92Tight junction_Homo sapiens_hsa045300.49290196
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48722173
94Mineral absorption_Homo sapiens_hsa049780.48501005
95Alcoholism_Homo sapiens_hsa050340.48252001
96Oocyte meiosis_Homo sapiens_hsa041140.47908408
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47524483
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46705367
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46374650
100Ovarian steroidogenesis_Homo sapiens_hsa049130.45894278
101Vitamin B6 metabolism_Homo sapiens_hsa007500.45843371
102VEGF signaling pathway_Homo sapiens_hsa043700.45334902
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.44819514
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44376619
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.43635254
106Prion diseases_Homo sapiens_hsa050200.43490475
107Sphingolipid metabolism_Homo sapiens_hsa006000.42816253
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.41884804
109Wnt signaling pathway_Homo sapiens_hsa043100.41257882
110PPAR signaling pathway_Homo sapiens_hsa033200.40946247
111African trypanosomiasis_Homo sapiens_hsa051430.40814117
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40704589
113Peroxisome_Homo sapiens_hsa041460.39962062
114Inositol phosphate metabolism_Homo sapiens_hsa005620.39950946
115Hedgehog signaling pathway_Homo sapiens_hsa043400.35006589
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34946412
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31991794
118Biosynthesis of amino acids_Homo sapiens_hsa012300.28204196

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