GPN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.45303412
2DNA deamination (GO:0045006)4.21836378
3purine nucleobase biosynthetic process (GO:0009113)4.20030908
4telomere maintenance via semi-conservative replication (GO:0032201)4.14666110
5nucleobase biosynthetic process (GO:0046112)4.13646296
6DNA double-strand break processing (GO:0000729)4.08593003
7DNA strand elongation involved in DNA replication (GO:0006271)4.05671611
8CENP-A containing nucleosome assembly (GO:0034080)4.05185271
9rRNA methylation (GO:0031167)3.99555996
10mitotic metaphase plate congression (GO:0007080)3.95636558
11chromatin remodeling at centromere (GO:0031055)3.93666930
12DNA strand elongation (GO:0022616)3.93052598
13telomere maintenance via recombination (GO:0000722)3.89193793
14maturation of SSU-rRNA (GO:0030490)3.87611118
15DNA replication initiation (GO:0006270)3.87141111
16ribosome biogenesis (GO:0042254)3.80432477
17spliceosomal snRNP assembly (GO:0000387)3.75813939
18transcription elongation from RNA polymerase III promoter (GO:0006385)3.75160266
19termination of RNA polymerase III transcription (GO:0006386)3.75160266
20kinetochore assembly (GO:0051382)3.74855017
21ribosomal small subunit assembly (GO:0000028)3.73425813
227-methylguanosine mRNA capping (GO:0006370)3.72720572
23RNA capping (GO:0036260)3.70586283
247-methylguanosine RNA capping (GO:0009452)3.70586283
25viral mRNA export from host cell nucleus (GO:0046784)3.68950772
26transcription-coupled nucleotide-excision repair (GO:0006283)3.66675987
27ribosomal large subunit biogenesis (GO:0042273)3.66547903
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.66407832
29kinetochore organization (GO:0051383)3.65505609
30DNA replication checkpoint (GO:0000076)3.62907858
31DNA ligation (GO:0006266)3.62449090
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59866447
33DNA catabolic process, exonucleolytic (GO:0000738)3.59405762
34mitotic recombination (GO:0006312)3.58991896
35establishment of viral latency (GO:0019043)3.58077138
36ribonucleoprotein complex biogenesis (GO:0022613)3.57087763
37metaphase plate congression (GO:0051310)3.55980031
38regulation of ubiquitin-protein transferase activity (GO:0051438)3.55571353
39anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.53756397
40replication fork processing (GO:0031297)3.52484145
41telomere maintenance via telomere lengthening (GO:0010833)3.52188876
42positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.51907059
43regulation of nuclear cell cycle DNA replication (GO:0033262)3.50632555
44RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.50522999
45tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.50522999
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.49461197
47rRNA modification (GO:0000154)3.48511647
48spliceosomal complex assembly (GO:0000245)3.47578618
49nucleotide-excision repair, DNA gap filling (GO:0006297)3.46448543
50regulation of ligase activity (GO:0051340)3.43615838
51transcription elongation from RNA polymerase I promoter (GO:0006362)3.42020145
52deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.39550690
53cullin deneddylation (GO:0010388)3.39330272
54termination of RNA polymerase I transcription (GO:0006363)3.37093124
55DNA replication-independent nucleosome organization (GO:0034724)3.37068238
56DNA replication-independent nucleosome assembly (GO:0006336)3.37068238
57transcription from RNA polymerase I promoter (GO:0006360)3.35049391
58pseudouridine synthesis (GO:0001522)3.31946768
59IMP biosynthetic process (GO:0006188)3.31026542
60DNA damage response, detection of DNA damage (GO:0042769)3.30645601
61mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.29388274
62negative regulation of ligase activity (GO:0051352)3.27396808
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.27396808
64histone H2A acetylation (GO:0043968)3.26930200
65protein deneddylation (GO:0000338)3.24423033
66histone exchange (GO:0043486)3.23869533
67rRNA processing (GO:0006364)3.23469023
68maturation of 5.8S rRNA (GO:0000460)3.21104130
69ribosome assembly (GO:0042255)3.20414257
70establishment of chromosome localization (GO:0051303)3.17440128
71positive regulation of cell cycle arrest (GO:0071158)3.17222948
72respiratory chain complex IV assembly (GO:0008535)3.15611017
73rRNA metabolic process (GO:0016072)3.14053555
74microtubule depolymerization (GO:0007019)3.14038880
75signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.13383896
76signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.13383896
77signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.13383896
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.12017891
79DNA-dependent DNA replication (GO:0006261)3.11766393
80negative regulation of protein ubiquitination (GO:0031397)3.11104813
81DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.09905030
82DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.09796286
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09622782
84cellular component biogenesis (GO:0044085)3.08392718
85establishment of integrated proviral latency (GO:0075713)3.06939204
86deoxyribonucleotide biosynthetic process (GO:0009263)3.05860413
87regulation of double-strand break repair via homologous recombination (GO:0010569)3.05671869
88signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.05518082
89intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.05518082
90signal transduction involved in DNA damage checkpoint (GO:0072422)3.05433858
91signal transduction involved in DNA integrity checkpoint (GO:0072401)3.05433858
92signal transduction involved in cell cycle checkpoint (GO:0072395)3.05432388
93DNA replication-dependent nucleosome organization (GO:0034723)3.05410480
94DNA replication-dependent nucleosome assembly (GO:0006335)3.05410480
95positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.05191561
96regulation of cellular amine metabolic process (GO:0033238)3.03527441
97chaperone-mediated protein transport (GO:0072321)3.03371499
98mitochondrial RNA metabolic process (GO:0000959)3.03192844
99transcription initiation from RNA polymerase I promoter (GO:0006361)3.02142607
100protein localization to kinetochore (GO:0034501)3.02021506
101meiotic chromosome segregation (GO:0045132)2.99905516
102regulation of cellular amino acid metabolic process (GO:0006521)2.97717957
103formation of translation preinitiation complex (GO:0001731)2.97541515
104mismatch repair (GO:0006298)2.96920926
105pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.96701998
106antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.96148260
107spindle checkpoint (GO:0031577)2.95391575
108negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.94241925
109tRNA methylation (GO:0030488)2.92875341
110regulation of spindle organization (GO:0090224)2.92621051
111regulation of mitochondrial translation (GO:0070129)2.92393245
112ribosomal small subunit biogenesis (GO:0042274)2.92254901
113deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.91660042
114negative regulation of mitotic sister chromatid separation (GO:2000816)2.91460805
115negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91460805
116negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.91460805
117negative regulation of sister chromatid segregation (GO:0033046)2.91460805
118oxidative phosphorylation (GO:0006119)2.91421584
119response to X-ray (GO:0010165)2.90841381
120positive regulation of ligase activity (GO:0051351)2.89932143
121somatic hypermutation of immunoglobulin genes (GO:0016446)2.89810367
122somatic diversification of immune receptors via somatic mutation (GO:0002566)2.89810367
123regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.89399241
124maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.89174745
125G1/S transition of mitotic cell cycle (GO:0000082)2.89095965
126cell cycle G1/S phase transition (GO:0044843)2.89095965
127attachment of spindle microtubules to kinetochore (GO:0008608)2.87593100
128negative regulation of chromosome segregation (GO:0051985)2.86800623
129RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.86000453
130tRNA aminoacylation for protein translation (GO:0006418)2.84523310
131non-recombinational repair (GO:0000726)2.82977958
132double-strand break repair via nonhomologous end joining (GO:0006303)2.82977958
133peptidyl-histidine modification (GO:0018202)2.82887826
134mitotic sister chromatid segregation (GO:0000070)2.82802335
135amino acid activation (GO:0043038)2.80010166
136tRNA aminoacylation (GO:0043039)2.80010166
137protein targeting to mitochondrion (GO:0006626)2.79783669
138GMP metabolic process (GO:0046037)2.79442414
139histone mRNA metabolic process (GO:0008334)2.78833592
140IMP metabolic process (GO:0046040)2.77934152
141mitotic spindle checkpoint (GO:0071174)2.76796127
142dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.76617956

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.96571771
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.41024900
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.18891953
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.90075615
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.67139349
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.61525168
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.56320567
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.50532725
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.19985446
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.10633354
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.05835806
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.97050441
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89731711
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.89159606
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86995095
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86666548
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.77066423
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.67181073
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64247575
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.57883960
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.53988810
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.48012079
23* VDR_23849224_ChIP-Seq_CD4+_Human2.44412394
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.29923106
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27195473
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23049920
27* YY1_21170310_ChIP-Seq_MESCs_Mouse2.22043479
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.21892178
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.15483174
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.15454119
31XRN2_22483619_ChIP-Seq_HELA_Human2.15064559
32E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08319526
33FOXP3_21729870_ChIP-Seq_TREG_Human2.07883102
34DCP1A_22483619_ChIP-Seq_HELA_Human2.07732921
35* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.07534890
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.98021574
37TTF2_22483619_ChIP-Seq_HELA_Human1.96782962
38ELK1_19687146_ChIP-ChIP_HELA_Human1.96512173
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.92807573
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.90673343
41* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87511111
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.85081438
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81297288
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76535652
45GABP_19822575_ChIP-Seq_HepG2_Human1.74888470
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72901938
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.70710652
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70459242
49* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69221034
50ZNF274_21170338_ChIP-Seq_K562_Hela1.61785947
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59102944
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56405093
53CIITA_25753668_ChIP-Seq_RAJI_Human1.54380386
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.53241098
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51221912
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48017694
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.39041037
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.34800982
59IRF1_19129219_ChIP-ChIP_H3396_Human1.34029439
60AR_21909140_ChIP-Seq_LNCAP_Human1.33137028
61* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.31878719
62MYC_18940864_ChIP-ChIP_HL60_Human1.31349498
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31208953
64* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29170906
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.27247695
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.25592436
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22807767
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18861273
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14574654
70NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.09693608
71VDR_22108803_ChIP-Seq_LS180_Human1.09448612
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09330570
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09124537
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07631751
75KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05411324
76KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05411324
77KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05411324
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03991521
79ELK1_22589737_ChIP-Seq_MCF10A_Human1.03285162
80KDM5A_27292631_Chip-Seq_BREAST_Human1.01558884
81* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01276248
82CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00277477
83SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99968832
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98014775
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94615019
86IGF1R_20145208_ChIP-Seq_DFB_Human0.94089709
87POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89349289
88SOX2_16153702_ChIP-ChIP_HESCs_Human0.89036059
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88190117
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86919127
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85748286
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84433919
93FLI1_27457419_Chip-Seq_LIVER_Mouse0.83067487
94NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82490372
95SOX17_20123909_ChIP-Seq_XEN_Mouse0.82174901
96NANOG_16153702_ChIP-ChIP_HESCs_Human0.81697073
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81350375
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.80061526
99ELF5_23300383_ChIP-Seq_T47D_Human0.80043937
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.79391095
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.77488608
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76500631
103PCGF2_27294783_Chip-Seq_ESCs_Mouse0.76200353
104FUS_26573619_Chip-Seq_HEK293_Human0.76127799
105CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.74907479
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73142916
107EWS_26573619_Chip-Seq_HEK293_Human0.72587253
108KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72246751
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.71614497
110CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.71449655
111SALL4_22934838_ChIP-ChIP_CD34+_Human0.70808290
112P300_19829295_ChIP-Seq_ESCs_Human0.69713068
113TFEB_21752829_ChIP-Seq_HELA_Human0.69688245
114PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.69401311
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.69029248
116STAT3_1855785_ChIP-Seq_MESCs_Mouse0.66365815
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.65796822
118IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.65703942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.79525384
2MP0008058_abnormal_DNA_repair4.14481381
3MP0003111_abnormal_nucleus_morphology4.12676618
4MP0010094_abnormal_chromosome_stability4.07140910
5MP0003806_abnormal_nucleotide_metabolis3.84161993
6MP0008057_abnormal_DNA_replication3.83442267
7MP0006292_abnormal_olfactory_placode3.61154668
8MP0004957_abnormal_blastocyst_morpholog3.44647072
9MP0003077_abnormal_cell_cycle3.39445975
10MP0008877_abnormal_DNA_methylation2.98391616
11MP0008007_abnormal_cellular_replicative2.66727727
12MP0008932_abnormal_embryonic_tissue2.61767324
13MP0003786_premature_aging2.48350370
14MP0003718_maternal_effect2.33057654
15MP0003941_abnormal_skin_development2.13775397
16MP0003136_yellow_coat_color2.09370539
17MP0006036_abnormal_mitochondrial_physio2.05310677
18MP0001188_hyperpigmentation2.00798185
19MP0003123_paternal_imprinting1.93010708
20MP0001986_abnormal_taste_sensitivity1.85506763
21MP0000566_synostosis1.80665145
22MP0003315_abnormal_perineum_morphology1.79753518
23MP0001529_abnormal_vocalization1.68941781
24MP0002160_abnormal_reproductive_system1.54861611
25MP0003121_genomic_imprinting1.53756090
26MP0000358_abnormal_cell_content/1.51410941
27MP0002210_abnormal_sex_determination1.43515771
28MP0002102_abnormal_ear_morphology1.43001601
29MP0002254_reproductive_system_inflammat1.40962630
30MP0003195_calcinosis1.40026192
31MP0000350_abnormal_cell_proliferation1.38367620
32MP0001661_extended_life_span1.36983100
33MP0002396_abnormal_hematopoietic_system1.36207638
34MP0004133_heterotaxia1.34078466
35MP0005389_reproductive_system_phenotype1.32394336
36MP0000516_abnormal_urinary_system1.29108146
37MP0005367_renal/urinary_system_phenotyp1.29108146
38MP0000749_muscle_degeneration1.28798605
39MP0010030_abnormal_orbit_morphology1.28773796
40MP0009697_abnormal_copulation1.28087391
41MP0003890_abnormal_embryonic-extraembry1.26238766
42MP0006054_spinal_hemorrhage1.26138121
43MP0001730_embryonic_growth_arrest1.26101940
44MP0005084_abnormal_gallbladder_morpholo1.25041761
45MP0002132_abnormal_respiratory_system1.23890459
46MP0002277_abnormal_respiratory_mucosa1.17603107
47MP0002938_white_spotting1.17171608
48MP0001145_abnormal_male_reproductive1.16370119
49MP0001919_abnormal_reproductive_system1.15236608
50MP0009379_abnormal_foot_pigmentation1.14564555
51MP0000015_abnormal_ear_pigmentation1.13854534
52MP0002233_abnormal_nose_morphology1.11769983
53MP0008995_early_reproductive_senescence1.10260084
54MP0000313_abnormal_cell_death1.07979991
55MP0000049_abnormal_middle_ear1.07866804
56MP0000653_abnormal_sex_gland1.06742514
57MP0002751_abnormal_autonomic_nervous1.06255214
58MP0008789_abnormal_olfactory_epithelium1.05430196
59MP0008875_abnormal_xenobiotic_pharmacok1.04673504
60MP0003787_abnormal_imprinting1.03427353
61MP0001119_abnormal_female_reproductive1.02878791
62MP0002638_abnormal_pupillary_reflex1.02663381
63MP0000647_abnormal_sebaceous_gland1.02559351
64MP0001929_abnormal_gametogenesis1.01989786
65MP0002163_abnormal_gland_morphology1.01612993
66MP0004147_increased_porphyrin_level1.00733442
67MP0005377_hearing/vestibular/ear_phenot1.00395404
68MP0003878_abnormal_ear_physiology1.00395404
69MP0001672_abnormal_embryogenesis/_devel1.00015926
70MP0005380_embryogenesis_phenotype1.00015926
71MP0005379_endocrine/exocrine_gland_phen0.99144770
72MP0002085_abnormal_embryonic_tissue0.97494932
73MP0005395_other_phenotype0.95783798
74MP0005410_abnormal_fertilization0.95470167
75MP0003938_abnormal_ear_development0.95329306
76MP0001293_anophthalmia0.94950750
77MP0008260_abnormal_autophagy0.94670564
78MP0001697_abnormal_embryo_size0.94247046
79MP0001984_abnormal_olfaction0.92526455
80MP0001905_abnormal_dopamine_level0.92517921
81MP0005409_darkened_coat_color0.92178181
82MP0009333_abnormal_splenocyte_physiolog0.92049448
83MP0005075_abnormal_melanosome_morpholog0.91425550
84MP0003937_abnormal_limbs/digits/tail_de0.90697314
85MP0002095_abnormal_skin_pigmentation0.89439866
86MP0000490_abnormal_crypts_of0.88926094
87MP0002234_abnormal_pharynx_morphology0.88715840
88MP0003646_muscle_fatigue0.88687248
89MP0002080_prenatal_lethality0.87165347
90MP0005171_absent_coat_pigmentation0.86632477
91MP0010307_abnormal_tumor_latency0.84211175
92MP0001286_abnormal_eye_development0.84200462
93MP0006276_abnormal_autonomic_nervous0.83498207
94MP0002019_abnormal_tumor_incidence0.82708524
95MP0002282_abnormal_trachea_morphology0.82488296
96MP0005330_cardiomyopathy0.81488291
97MP0003119_abnormal_digestive_system0.80722327
98MP0005394_taste/olfaction_phenotype0.79932632
99MP0005499_abnormal_olfactory_system0.79932632
100MP0002090_abnormal_vision0.79477563
101MP0000372_irregular_coat_pigmentation0.78158931
102MP0004215_abnormal_myocardial_fiber0.77985487
103MP0006072_abnormal_retinal_apoptosis0.77615637
104MP0000427_abnormal_hair_cycle0.77161004
105MP0006035_abnormal_mitochondrial_morpho0.76930105
106MP0002111_abnormal_tail_morphology0.76893121
107MP0003186_abnormal_redox_activity0.76726870
108MP0008873_increased_physiological_sensi0.74956699
109MP0003763_abnormal_thymus_physiology0.74913031
110MP0003950_abnormal_plasma_membrane0.74656885
111MP0003984_embryonic_growth_retardation0.72417886
112MP0001853_heart_inflammation0.71678602
113MP0005423_abnormal_somatic_nervous0.71501066
114MP0001764_abnormal_homeostasis0.71207469
115MP0001186_pigmentation_phenotype0.71059040
116MP0003122_maternal_imprinting0.70507350
117MP0002088_abnormal_embryonic_growth/wei0.69835666
118MP0003698_abnormal_male_reproductive0.69679277
119MP0000678_abnormal_parathyroid_gland0.69043820
120MP0002249_abnormal_larynx_morphology0.68893358
121MP0005408_hypopigmentation0.67644415
122MP0003936_abnormal_reproductive_system0.67199358
123MP0000026_abnormal_inner_ear0.65945428
124MP0002086_abnormal_extraembryonic_tissu0.65925450
125MP0005332_abnormal_amino_acid0.64341061
126MP0002084_abnormal_developmental_patter0.63920892
127MP0003221_abnormal_cardiomyocyte_apopto0.63918825
128MP0002736_abnormal_nociception_after0.63342268
129MP0004381_abnormal_hair_follicle0.62812925
130MP0000703_abnormal_thymus_morphology0.62764191
131MP0002269_muscular_atrophy0.61101091
132MP0004808_abnormal_hematopoietic_stem0.60958528
133MP0005253_abnormal_eye_physiology0.60161088
134MP0004197_abnormal_fetal_growth/weight/0.60117012
135MP0000631_abnormal_neuroendocrine_gland0.59279770
136MP0009250_abnormal_appendicular_skeleto0.59184537
137MP0003567_abnormal_fetal_cardiomyocyte0.58440949

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.56804330
2Birth length less than 3rd percentile (HP:0003561)4.54322723
3Chromsome breakage (HP:0040012)4.32036953
4Reduced antithrombin III activity (HP:0001976)3.43405569
5Breast hypoplasia (HP:0003187)3.40057375
6Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.34398631
7Abnormal protein N-linked glycosylation (HP:0012347)3.34398631
8Abnormal protein glycosylation (HP:0012346)3.34398631
9Abnormal glycosylation (HP:0012345)3.34398631
10Meckel diverticulum (HP:0002245)3.29709518
11Abnormality of the preputium (HP:0100587)3.25820944
12Reticulocytopenia (HP:0001896)3.18996781
13Patellar aplasia (HP:0006443)3.16328436
14Abnormality of the ileum (HP:0001549)3.15119708
15Lipid accumulation in hepatocytes (HP:0006561)3.11555371
16Aplasia/Hypoplasia of the uvula (HP:0010293)2.99297983
17Aplasia/Hypoplasia of the patella (HP:0006498)2.99248732
18Cerebral hypomyelination (HP:0006808)2.98898868
19Abnormality of methionine metabolism (HP:0010901)2.91519150
20Increased serum pyruvate (HP:0003542)2.88109469
21Supernumerary spleens (HP:0009799)2.80766785
22Carpal bone hypoplasia (HP:0001498)2.75708983
23Abnormality of the renal collecting system (HP:0004742)2.75680445
24Oral leukoplakia (HP:0002745)2.75061256
25Abnormality of chromosome stability (HP:0003220)2.71945569
26Duplicated collecting system (HP:0000081)2.71299794
27Abnormality of glycolysis (HP:0004366)2.69873290
28Rough bone trabeculation (HP:0100670)2.64118856
29Abnormality of the anterior horn cell (HP:0006802)2.62923798
30Degeneration of anterior horn cells (HP:0002398)2.62923798
31Methylmalonic acidemia (HP:0002912)2.61581381
32Acute necrotizing encephalopathy (HP:0006965)2.60076762
33Absent radius (HP:0003974)2.59484121
34Abnormal lung lobation (HP:0002101)2.57699964
35Abnormality of the labia minora (HP:0012880)2.57165216
36Microvesicular hepatic steatosis (HP:0001414)2.57019990
37Horseshoe kidney (HP:0000085)2.56645099
38Medulloblastoma (HP:0002885)2.55196007
39Impulsivity (HP:0100710)2.54757185
40Colon cancer (HP:0003003)2.54583928
41Absent thumb (HP:0009777)2.50940346
42Lactic acidosis (HP:0003128)2.49427183
43Agnosia (HP:0010524)2.48108471
44Aplastic anemia (HP:0001915)2.47498385
45Bone marrow hypocellularity (HP:0005528)2.46947402
46Aplasia involving forearm bones (HP:0009822)2.46417783
47Absent forearm bone (HP:0003953)2.46417783
48Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.44903656
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.44231020
50Duodenal stenosis (HP:0100867)2.44152448
51Small intestinal stenosis (HP:0012848)2.44152448
52Cerebral edema (HP:0002181)2.42536459
53Renal Fanconi syndrome (HP:0001994)2.40603613
54Abnormality of DNA repair (HP:0003254)2.40521105
55Premature graying of hair (HP:0002216)2.40138457
56Type I transferrin isoform profile (HP:0003642)2.39633242
573-Methylglutaconic aciduria (HP:0003535)2.38318345
58Triphalangeal thumb (HP:0001199)2.33310632
59Volvulus (HP:0002580)2.32301362
60Abnormal mitochondria in muscle tissue (HP:0008316)2.31129931
61Mitochondrial inheritance (HP:0001427)2.30567076
62Methylmalonic aciduria (HP:0012120)2.30075131
63Pancreatic cysts (HP:0001737)2.29820092
6411 pairs of ribs (HP:0000878)2.27781362
65Pancreatic fibrosis (HP:0100732)2.27141595
66Increased serum lactate (HP:0002151)2.27038930
67True hermaphroditism (HP:0010459)2.25838307
68Increased CSF lactate (HP:0002490)2.22005979
69Ectopic kidney (HP:0000086)2.21349858
70Abnormality of placental membranes (HP:0011409)2.21308387
71Amniotic constriction ring (HP:0009775)2.21308387
72Nephroblastoma (Wilms tumor) (HP:0002667)2.20647074
73Abnormality of cells of the erythroid lineage (HP:0012130)2.15968474
74Abnormal number of erythroid precursors (HP:0012131)2.15424777
75Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.14575289
76Hepatocellular necrosis (HP:0001404)2.14141712
77Septo-optic dysplasia (HP:0100842)2.13899237
78Clubbing of toes (HP:0100760)2.13202585
79Median cleft lip (HP:0000161)2.12954108
80Myelodysplasia (HP:0002863)2.12262222
81Ependymoma (HP:0002888)2.11335506
82Sloping forehead (HP:0000340)2.10031052
83Embryonal renal neoplasm (HP:0011794)2.08807894
84Postnatal microcephaly (HP:0005484)2.08026898
85Congenital stationary night blindness (HP:0007642)2.06031432
86Abnormality of the duodenum (HP:0002246)2.05687644
87Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.05477711
88Neoplasm of the adrenal gland (HP:0100631)2.03503662
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02528688
90Abnormality of alanine metabolism (HP:0010916)2.02528688
91Hyperalaninemia (HP:0003348)2.02528688
92Abnormal trabecular bone morphology (HP:0100671)2.00246125
93Respiratory failure (HP:0002878)1.99463934
94Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.98953912
95Decreased activity of mitochondrial respiratory chain (HP:0008972)1.98953912
96Progressive macrocephaly (HP:0004481)1.98498861
97Type 2 muscle fiber atrophy (HP:0003554)1.98176999
98Abnormality of serum amino acid levels (HP:0003112)1.97500985
99Macrocytic anemia (HP:0001972)1.93277089
100Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92974382
101Retinal dysplasia (HP:0007973)1.92519735
102Severe visual impairment (HP:0001141)1.92094961
103Lethargy (HP:0001254)1.91710766
104Pancytopenia (HP:0001876)1.91272077
105Hypoplastic pelvis (HP:0008839)1.91257364
106Facial cleft (HP:0002006)1.90691073
107Abnormality of midbrain morphology (HP:0002418)1.90485046
108Molar tooth sign on MRI (HP:0002419)1.90485046
109Megaloblastic anemia (HP:0001889)1.90258626
110Short tibia (HP:0005736)1.90200671
111Neoplasm of the pancreas (HP:0002894)1.88034707
112Preaxial hand polydactyly (HP:0001177)1.87865351
113Hypoplasia of the radius (HP:0002984)1.87698723
114Tracheoesophageal fistula (HP:0002575)1.87347662
115Cellular immunodeficiency (HP:0005374)1.87016757
116Short thumb (HP:0009778)1.86390828
117Secondary amenorrhea (HP:0000869)1.86273124
118Progressive external ophthalmoplegia (HP:0000590)1.85899149
119Abnormal number of incisors (HP:0011064)1.84989423
120Optic disc pallor (HP:0000543)1.84483545
121Exercise intolerance (HP:0003546)1.84477307
122Stomach cancer (HP:0012126)1.84376151
123Aplasia/hypoplasia of the uterus (HP:0008684)1.81155657
124Posterior subcapsular cataract (HP:0007787)1.80659814
125Pallor (HP:0000980)1.80261623
126Optic nerve coloboma (HP:0000588)1.79416192
127CNS demyelination (HP:0007305)1.78662861
128Bifid tongue (HP:0010297)1.78162868
129Dyschromatopsia (HP:0007641)1.78129359
130Aplasia/Hypoplasia of the sternum (HP:0006714)1.77840615
131Cleft eyelid (HP:0000625)1.77143718
132Hyperglycinemia (HP:0002154)1.74513428
133Attenuation of retinal blood vessels (HP:0007843)1.74206483
134Abnormality of abdominal situs (HP:0011620)1.74178471
135Abdominal situs inversus (HP:0003363)1.74178471
136Squamous cell carcinoma (HP:0002860)1.73963595
137Acute encephalopathy (HP:0006846)1.71361327
138Abnormality of the carotid arteries (HP:0005344)1.70571037
139Breast aplasia (HP:0100783)1.69510913
140Hypothermia (HP:0002045)1.69399384
141Abnormalities of placenta or umbilical cord (HP:0001194)1.69045231
142Increased hepatocellular lipid droplets (HP:0006565)1.68861329
143Opisthotonus (HP:0002179)1.68769394
144Hepatic necrosis (HP:0002605)1.68327811
145Abnormal sex determination (HP:0012244)1.68139618
146Sex reversal (HP:0012245)1.68139618
147Abnormality of sulfur amino acid metabolism (HP:0004339)1.67579719
148CNS hypomyelination (HP:0003429)1.67080413
149Hypoproteinemia (HP:0003075)1.65323656
150Single umbilical artery (HP:0001195)1.63365885
151Abnormality of the fetal cardiovascular system (HP:0010948)1.63365885

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.59002416
2STK163.72159987
3VRK23.16596906
4SRPK13.08649553
5WEE13.06752500
6PLK42.99032418
7TRIM282.94498409
8ZAK2.73806318
9TAF12.73198970
10EIF2AK12.46617473
11TSSK62.42213862
12CDC72.38848774
13MKNK12.38001179
14VRK12.28017954
15MKNK22.25212249
16IRAK32.18856377
17CASK2.02682382
18PLK31.97214395
19TLK11.96883439
20TTK1.91151836
21WNK31.84917319
22PLK11.80813632
23IRAK41.72768352
24EIF2AK31.71903414
25EIF2AK21.65847890
26CCNB11.62224765
27BRSK21.59160001
28PBK1.51970208
29BCKDK1.49877861
30CSNK1G31.37609842
31AKT31.37167938
32ACVR1B1.36991023
33PASK1.35939118
34ATR1.32361752
35STK38L1.31684089
36EPHA21.29447474
37AURKA1.27267927
38CDK71.26481085
39CHEK21.21606375
40CSNK1G11.20237998
41NME21.20011911
42CSNK1A1L1.19906982
43TESK21.18885455
44AURKB1.18492133
45BRSK11.18243649
46BRAF1.14536685
47MAP4K21.12340999
48NEK21.11768263
49NME11.11125103
50CSNK1G21.10586908
51TAOK21.08576952
52PNCK1.07025443
53IRAK21.05366147
54ADRBK21.01527970
55BMPR1B1.01464783
56PDK20.99763636
57DYRK20.96583221
58NEK60.94366147
59DYRK30.92410238
60PINK10.90036875
61YES10.86294983
62DAPK10.84225706
63MARK10.81981681
64FRK0.81768740
65CDK80.81550682
66TXK0.80508253
67ERBB40.79989704
68CHEK10.78851748
69FLT30.74559729
70CSNK2A10.73027530
71STK240.69811265
72RPS6KA50.69185705
73PLK20.66619150
74STK40.65976740
75PRKCI0.65341887
76TGFBR10.64492527
77PRPF4B0.64358291
78IRAK10.64291328
79GRK70.64116403
80TNIK0.63685493
81RPS6KB20.62575295
82CDK30.61567289
83TEC0.61325234
84PIM20.60925801
85ATM0.60896383
86BRD40.59974036
87NEK10.59239803
88CSNK2A20.58981708
89BMPR20.57684425
90MAPKAPK50.57580536
91OXSR10.54360813
92MAP3K120.53616392
93CDK20.52277961
94MAP2K70.50254838
95MAP3K80.50137480
96MST1R0.49473938
97CDK10.48439888
98STK390.47756841
99PAK10.47568120
100MELK0.46656372
101CDK190.46530793
102LIMK10.46474214
103MAPK130.46010498
104SIK30.45824054
105CLK10.45105804
106RAF10.43516124
107NUAK10.42852345
108GRK10.42549499
109ERBB30.41817307
110TNK20.41498271
111SCYL20.40757177
112STK100.39716549
113BLK0.39174464
114MINK10.39099776
115PAK40.37856165
116STK30.36684297
117RPS6KA40.33213073
118MST40.32915197
119PRKCE0.30053274
120MUSK0.30050525
121PIM10.29701682
122OBSCN0.28215687
123IKBKB0.27443929
124MET0.26421433
125AKT20.25147139
126EGFR0.24961538
127ILK0.24111002
128CDK90.23848367
129BCR0.22658220
130KDR0.22622411
131CDK40.22255460
132MYLK0.22054538

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.19083528
2Mismatch repair_Homo sapiens_hsa034304.14584820
3Proteasome_Homo sapiens_hsa030504.06956711
4RNA polymerase_Homo sapiens_hsa030203.98440939
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.64233899
6Homologous recombination_Homo sapiens_hsa034403.25222683
7Ribosome_Homo sapiens_hsa030103.23764689
8Spliceosome_Homo sapiens_hsa030403.09139835
9Base excision repair_Homo sapiens_hsa034102.95047666
10Nucleotide excision repair_Homo sapiens_hsa034202.91946982
11Fanconi anemia pathway_Homo sapiens_hsa034602.73393919
12RNA transport_Homo sapiens_hsa030132.68949507
13Pyrimidine metabolism_Homo sapiens_hsa002402.67661310
14Basal transcription factors_Homo sapiens_hsa030222.35195837
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28770042
16Cell cycle_Homo sapiens_hsa041102.22002837
17One carbon pool by folate_Homo sapiens_hsa006702.18604583
18Non-homologous end-joining_Homo sapiens_hsa034502.11689353
19Propanoate metabolism_Homo sapiens_hsa006401.95537012
20RNA degradation_Homo sapiens_hsa030181.85287597
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.80832636
22Fatty acid elongation_Homo sapiens_hsa000621.71597593
23Purine metabolism_Homo sapiens_hsa002301.71219289
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57797995
25Oxidative phosphorylation_Homo sapiens_hsa001901.52463925
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52316012
27Pyruvate metabolism_Homo sapiens_hsa006201.52305275
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51991091
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49004724
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44340608
31mRNA surveillance pathway_Homo sapiens_hsa030151.41380844
32Parkinsons disease_Homo sapiens_hsa050121.37981440
33Huntingtons disease_Homo sapiens_hsa050161.37060209
34Protein export_Homo sapiens_hsa030601.34444511
35Steroid biosynthesis_Homo sapiens_hsa001001.27866499
36p53 signaling pathway_Homo sapiens_hsa041151.18974935
37Epstein-Barr virus infection_Homo sapiens_hsa051691.15442122
38Phototransduction_Homo sapiens_hsa047441.14714896
39Sulfur metabolism_Homo sapiens_hsa009201.14079184
40Carbon metabolism_Homo sapiens_hsa012001.08341119
41Selenocompound metabolism_Homo sapiens_hsa004501.08258716
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05991730
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04389048
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01615624
45Vitamin B6 metabolism_Homo sapiens_hsa007500.97943175
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96907256
47Systemic lupus erythematosus_Homo sapiens_hsa053220.89912220
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87488866
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85311333
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77094235
51Peroxisome_Homo sapiens_hsa041460.76652949
52Butanoate metabolism_Homo sapiens_hsa006500.76232611
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75452435
54Alzheimers disease_Homo sapiens_hsa050100.72740054
55Arachidonic acid metabolism_Homo sapiens_hsa005900.72089832
56Herpes simplex infection_Homo sapiens_hsa051680.70995689
57Oocyte meiosis_Homo sapiens_hsa041140.70033851
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68282186
59Fatty acid metabolism_Homo sapiens_hsa012120.63598266
60Allograft rejection_Homo sapiens_hsa053300.60893365
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.60037623
62Folate biosynthesis_Homo sapiens_hsa007900.59675072
63Autoimmune thyroid disease_Homo sapiens_hsa053200.59202847
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57972554
65Primary immunodeficiency_Homo sapiens_hsa053400.55580938
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54105109
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50711838
68Fatty acid degradation_Homo sapiens_hsa000710.49557189
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.48160945
70Viral carcinogenesis_Homo sapiens_hsa052030.46529255
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45729598
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.45116126
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44346790
74Metabolic pathways_Homo sapiens_hsa011000.42748613
75HTLV-I infection_Homo sapiens_hsa051660.41697617
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41559345
77Other glycan degradation_Homo sapiens_hsa005110.41441518
78Asthma_Homo sapiens_hsa053100.41008861
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40344881
80Antigen processing and presentation_Homo sapiens_hsa046120.38653445
81Caffeine metabolism_Homo sapiens_hsa002320.38396168
82Tryptophan metabolism_Homo sapiens_hsa003800.37627843
83Alcoholism_Homo sapiens_hsa050340.37397843
84Glutathione metabolism_Homo sapiens_hsa004800.37201910
85Nitrogen metabolism_Homo sapiens_hsa009100.36833142
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35540524
87TGF-beta signaling pathway_Homo sapiens_hsa043500.34899504
88Pentose phosphate pathway_Homo sapiens_hsa000300.34859867
89Measles_Homo sapiens_hsa051620.34775182
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.34251769
91Graft-versus-host disease_Homo sapiens_hsa053320.33255758
92Legionellosis_Homo sapiens_hsa051340.32992475
93Linoleic acid metabolism_Homo sapiens_hsa005910.32609432
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32084708
95beta-Alanine metabolism_Homo sapiens_hsa004100.27189089
96Regulation of autophagy_Homo sapiens_hsa041400.26417981
97Biosynthesis of amino acids_Homo sapiens_hsa012300.25834895
98Arginine and proline metabolism_Homo sapiens_hsa003300.23311568
99Basal cell carcinoma_Homo sapiens_hsa052170.22317282
100Nicotine addiction_Homo sapiens_hsa050330.21810043
101Ether lipid metabolism_Homo sapiens_hsa005650.21523385
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21171392
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20175871
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19816700
105Type I diabetes mellitus_Homo sapiens_hsa049400.19172155
106Hematopoietic cell lineage_Homo sapiens_hsa046400.19137982
107Chemical carcinogenesis_Homo sapiens_hsa052040.18513764
108Fructose and mannose metabolism_Homo sapiens_hsa000510.17728578
109Sulfur relay system_Homo sapiens_hsa041220.17394176
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16819193
111N-Glycan biosynthesis_Homo sapiens_hsa005100.16490970
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16412096
113Sphingolipid metabolism_Homo sapiens_hsa006000.16228400
114Shigellosis_Homo sapiens_hsa051310.15898768
115Collecting duct acid secretion_Homo sapiens_hsa049660.15861727
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15758296
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15577263
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.15423407
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15211420
120Cardiac muscle contraction_Homo sapiens_hsa042600.13726405
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.12634717
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12434149
123Vitamin digestion and absorption_Homo sapiens_hsa049770.12137953
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.11479841
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.11327663
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11191502
127Hedgehog signaling pathway_Homo sapiens_hsa043400.11026532
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.10252673
129Olfactory transduction_Homo sapiens_hsa047400.09923215
130Wnt signaling pathway_Homo sapiens_hsa043100.09650608
131Influenza A_Homo sapiens_hsa051640.09456511
132Rheumatoid arthritis_Homo sapiens_hsa053230.09116578
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.08667260
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.08622688
135Hippo signaling pathway_Homo sapiens_hsa043900.08157711
136Apoptosis_Homo sapiens_hsa042100.07737623
137Lysine degradation_Homo sapiens_hsa003100.07244869

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