GPN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)6.27763193
2tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)6.27763193
3homocysteine metabolic process (GO:0050667)6.10205952
4cysteine metabolic process (GO:0006534)5.89609103
5mitochondrial RNA metabolic process (GO:0000959)5.87359010
6negative regulation of Ras GTPase activity (GO:0034261)5.81081849
7sulfur amino acid catabolic process (GO:0000098)5.50146378
8tRNA modification (GO:0006400)5.29848557
9regulation of plasminogen activation (GO:0010755)5.07415071
10adenosine metabolic process (GO:0046085)5.02512491
11L-fucose catabolic process (GO:0042355)4.77812902
12fucose catabolic process (GO:0019317)4.77812902
13L-fucose metabolic process (GO:0042354)4.77812902
14regulation of vitamin D biosynthetic process (GO:0060556)4.70015648
15purine nucleotide salvage (GO:0032261)4.69847201
16microtubule nucleation (GO:0007020)4.64279027
17phosphatidylglycerol biosynthetic process (GO:0006655)4.50284023
18protein-cofactor linkage (GO:0018065)4.28866168
19white fat cell differentiation (GO:0050872)4.24726795
20folic acid-containing compound biosynthetic process (GO:0009396)4.24414167
21protein import into peroxisome matrix (GO:0016558)4.16648728
22mitotic metaphase plate congression (GO:0007080)4.14369789
23behavioral response to nicotine (GO:0035095)4.08450212
24DNA replication initiation (GO:0006270)4.04864056
25DNA strand elongation involved in DNA replication (GO:0006271)4.03726957
26epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.01234439
27DNA deamination (GO:0045006)3.88326877
28nucleoside transmembrane transport (GO:1901642)3.82174518
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.82121964
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.82121964
31NADH dehydrogenase complex assembly (GO:0010257)3.82121964
32DNA strand elongation (GO:0022616)3.81474387
33negative regulation of DNA biosynthetic process (GO:2000279)3.79401677
34preassembly of GPI anchor in ER membrane (GO:0016254)3.78337372
35telomere maintenance via semi-conservative replication (GO:0032201)3.76147399
36platelet dense granule organization (GO:0060155)3.76105940
37tRNA processing (GO:0008033)3.73618459
38sulfur amino acid biosynthetic process (GO:0000097)3.69723558
39DNA replication checkpoint (GO:0000076)3.68016850
40tetrahydrofolate metabolic process (GO:0046653)3.67713450
41folic acid-containing compound metabolic process (GO:0006760)3.63470615
42mitotic nuclear envelope disassembly (GO:0007077)3.62946794
43RNA modification (GO:0009451)3.61436279
44primary amino compound metabolic process (GO:1901160)3.59235506
45regulation of vitamin metabolic process (GO:0030656)3.56569588
46CENP-A containing nucleosome assembly (GO:0034080)3.54475335
47protein K6-linked ubiquitination (GO:0085020)3.54182793
48protein localization to kinetochore (GO:0034501)3.53440024
49rRNA methylation (GO:0031167)3.53117780
50ribosomal small subunit assembly (GO:0000028)3.52206039
51chromatin remodeling at centromere (GO:0031055)3.52101253
52DNA unwinding involved in DNA replication (GO:0006268)3.50526885
53galactose catabolic process (GO:0019388)3.49541512
54formation of translation preinitiation complex (GO:0001731)3.48081009
55telomere maintenance via recombination (GO:0000722)3.45820463
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.40865322
57maturation of SSU-rRNA (GO:0030490)3.39133671
58nuclear envelope disassembly (GO:0051081)3.34939073
59membrane disassembly (GO:0030397)3.34939073
60autophagic vacuole fusion (GO:0000046)3.34868215
61DNA replication-independent nucleosome assembly (GO:0006336)3.34052838
62DNA replication-independent nucleosome organization (GO:0034724)3.34052838
63DNA replication-dependent nucleosome organization (GO:0034723)3.33355546
64DNA replication-dependent nucleosome assembly (GO:0006335)3.33355546
65nucleobase biosynthetic process (GO:0046112)3.32431259
66prenylation (GO:0097354)3.31494517
67protein prenylation (GO:0018342)3.31494517
68metaphase plate congression (GO:0051310)3.31281942
69regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.30807893
70organic cation transport (GO:0015695)3.26924494
71protein localization to chromosome, centromeric region (GO:0071459)3.25267684
72attachment of spindle microtubules to kinetochore (GO:0008608)3.24874905
73protein complex biogenesis (GO:0070271)3.17175297
74folic acid metabolic process (GO:0046655)3.16778889
75proteasome assembly (GO:0043248)3.16735401
76mitotic recombination (GO:0006312)3.14447416
77positive regulation of endothelial cell differentiation (GO:0045603)3.13481891
78establishment of chromosome localization (GO:0051303)3.13180711
79ribosome assembly (GO:0042255)3.13137504
80regulation of sequestering of triglyceride (GO:0010889)3.13021050
81purine nucleobase biosynthetic process (GO:0009113)3.11803136
82maturation of 5.8S rRNA (GO:0000460)3.11703958
83pteridine-containing compound biosynthetic process (GO:0042559)3.11592536
84ribosome biogenesis (GO:0042254)3.09364102
85kinetochore assembly (GO:0051382)3.08438046
86viral transcription (GO:0019083)3.07134133
87negative regulation of interleukin-1 beta production (GO:0032691)3.06902423
88inner ear receptor cell development (GO:0060119)3.06814939
89spliceosomal snRNP assembly (GO:0000387)3.05754286
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05610796
91translational termination (GO:0006415)3.04291319
92regulation of spindle organization (GO:0090224)3.03860804
93one-carbon metabolic process (GO:0006730)3.03046092
94respiratory chain complex IV assembly (GO:0008535)3.00849198
95rRNA modification (GO:0000154)3.00758091
96ribosomal large subunit biogenesis (GO:0042273)3.00340782
97meiotic chromosome segregation (GO:0045132)2.99873260
98galactose metabolic process (GO:0006012)2.97124719
99eosinophil chemotaxis (GO:0048245)2.96191228
100histone exchange (GO:0043486)2.95118313
101regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.95079319
102mitochondrial respiratory chain complex assembly (GO:0033108)2.94947770
103ribonucleoprotein complex biogenesis (GO:0022613)2.94227777
104regulation of gonadotropin secretion (GO:0032276)2.93952195
105kinetochore organization (GO:0051383)2.93498208
106telomere maintenance via telomere lengthening (GO:0010833)2.93485023
107DNA damage response, signal transduction resulting in transcription (GO:0042772)2.93450674
108rRNA processing (GO:0006364)2.92456529
109translational initiation (GO:0006413)2.92254211
110cardiolipin metabolic process (GO:0032048)2.92245806
111mitotic sister chromatid segregation (GO:0000070)2.91658741
112regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.91597558
113positive regulation of mitotic sister chromatid separation (GO:1901970)2.90556912
114positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.90556912
115positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.90556912
116organelle membrane fusion (GO:0090174)2.89586747
117negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.88935765
118nucleotide-excision repair, DNA gap filling (GO:0006297)2.88716488
119pteridine-containing compound metabolic process (GO:0042558)2.88301140
120translational elongation (GO:0006414)2.87631176
121alternative mRNA splicing, via spliceosome (GO:0000380)2.86604626
122chromatin assembly or disassembly (GO:0006333)2.86525954
123regulation of double-strand break repair via homologous recombination (GO:0010569)2.84563983
124kynurenine metabolic process (GO:0070189)2.84339481
125mitotic chromosome condensation (GO:0007076)2.83984296
126desmosome organization (GO:0002934)2.83083502
127negative regulation of interleukin-1 production (GO:0032692)2.82252161
128rRNA metabolic process (GO:0016072)2.82092347
129RNA methylation (GO:0001510)2.82069705
130cellular ketone body metabolic process (GO:0046950)2.80530633
131pseudouridine synthesis (GO:0001522)2.79985396
132negative regulation of acute inflammatory response (GO:0002674)2.79767475
133sulfur amino acid metabolic process (GO:0000096)2.79358712
134transcription-coupled nucleotide-excision repair (GO:0006283)2.79044213
135transcription elongation from RNA polymerase III promoter (GO:0006385)2.78941706
136termination of RNA polymerase III transcription (GO:0006386)2.78941706
137deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.78266794
138acrosome assembly (GO:0001675)2.77566181
139positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.77493540
140L-serine metabolic process (GO:0006563)2.77452023
141L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.76150013
142ribosomal small subunit biogenesis (GO:0042274)2.75454725
143negative regulation of chromosome segregation (GO:0051985)2.75420668
144negative regulation of telomerase activity (GO:0051974)2.72989111
145negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.72476326
146nucleotide salvage (GO:0043173)2.72341712
147negative regulation of mitotic sister chromatid separation (GO:2000816)2.70676372
148negative regulation of mitotic sister chromatid segregation (GO:0033048)2.70676372
149negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.70676372
150negative regulation of sister chromatid segregation (GO:0033046)2.70676372
151spindle checkpoint (GO:0031577)2.70061897
152indole-containing compound catabolic process (GO:0042436)2.69708792
153indolalkylamine catabolic process (GO:0046218)2.69708792
154tryptophan catabolic process (GO:0006569)2.69708792
155tRNA metabolic process (GO:0006399)2.69663105
156nuclear envelope organization (GO:0006998)2.69182193
157regulation of chromosome segregation (GO:0051983)2.67986445
158protein complex localization (GO:0031503)2.67279901
159DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.66614555
160ATP hydrolysis coupled proton transport (GO:0015991)2.66356252
161energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.66356252
162methionine biosynthetic process (GO:0009086)2.66115482
163IMP biosynthetic process (GO:0006188)2.65812601
164G-protein coupled receptor internalization (GO:0002031)2.65744075
165negative regulation of ligase activity (GO:0051352)2.65653934
166negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.65653934
167IMP metabolic process (GO:0046040)2.64700717
168mitotic spindle assembly checkpoint (GO:0007094)2.63983443
169protein targeting to vacuole (GO:0006623)2.63584416
170protein targeting to lysosome (GO:0006622)2.63584416
171establishment of protein localization to vacuole (GO:0072666)2.63584416
172protein-chromophore linkage (GO:0018298)2.63420501
173spliceosomal complex assembly (GO:0000245)2.63389278
1747-methylguanosine mRNA capping (GO:0006370)2.63190931
175nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.63158087
176eosinophil migration (GO:0072677)2.63034883
177spindle assembly checkpoint (GO:0071173)2.62103376
178S-adenosylmethionine metabolic process (GO:0046500)2.61941494
179peroxisomal transport (GO:0043574)2.61777292
180CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.61193404
181fucosylation (GO:0036065)2.61147939
182chromosome segregation (GO:0007059)2.60439910
183GMP metabolic process (GO:0046037)2.60008215
184positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.59894246
185nuclear pore complex assembly (GO:0051292)2.59401649
186SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.59284416
187nuclear pore organization (GO:0006999)2.58468861
188protein localization to chromosome (GO:0034502)2.57512912
189mitotic spindle checkpoint (GO:0071174)2.56933817
190G1/S transition of mitotic cell cycle (GO:0000082)2.55304254
191cell cycle G1/S phase transition (GO:0044843)2.55304254

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.94421267
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.76928912
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.59197452
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47335773
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.43713143
6VDR_22108803_ChIP-Seq_LS180_Human3.24230831
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92505965
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.84409911
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.75658898
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.67922589
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66591907
12ZNF274_21170338_ChIP-Seq_K562_Hela2.59894142
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.59543225
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58282120
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.56036412
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.51461318
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.50784454
18GATA1_22025678_ChIP-Seq_K562_Human2.32728820
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.31007870
20XRN2_22483619_ChIP-Seq_HELA_Human2.21118801
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12125250
22VDR_23849224_ChIP-Seq_CD4+_Human2.03158194
23MYC_22102868_ChIP-Seq_BL_Human2.00893365
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99175312
25DCP1A_22483619_ChIP-Seq_HELA_Human1.96364797
26* GABP_19822575_ChIP-Seq_HepG2_Human1.96100314
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96031809
28EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.93584497
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91108514
30* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89303399
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.87469981
32AR_21909140_ChIP-Seq_LNCAP_Human1.86706882
33P68_20966046_ChIP-Seq_HELA_Human1.84983094
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84645327
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.78325202
36FOXP3_21729870_ChIP-Seq_TREG_Human1.75698516
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74679646
38E2F1_20622854_ChIP-Seq_HELA_Human1.74195637
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73987444
40BCL6_27268052_Chip-Seq_Bcells_Human1.68928851
41BCOR_27268052_Chip-Seq_Bcells_Human1.68046387
42* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.67726708
43TP53_22573176_ChIP-Seq_HFKS_Human1.67055809
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65005769
45RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.64744537
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.64236397
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63837423
48PHF8_20622854_ChIP-Seq_HELA_Human1.61093463
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61023884
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57263050
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55893746
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54545818
53TTF2_22483619_ChIP-Seq_HELA_Human1.53802649
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50825965
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50234265
56P300_27268052_Chip-Seq_Bcells_Human1.48900884
57CIITA_25753668_ChIP-Seq_RAJI_Human1.48471371
58YY1_22570637_ChIP-Seq_MALME-3M_Human1.47666700
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46710193
60* KDM5A_27292631_Chip-Seq_BREAST_Human1.46667624
61STAT1_20625510_ChIP-Seq_HELA_Human1.42282735
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41239830
63EGR1_19374776_ChIP-ChIP_THP-1_Human1.40243029
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39921156
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39537754
66* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39364876
67* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38867338
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38863030
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37402730
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35599160
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33655864
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31076546
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30947194
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.30887093
75VDR_21846776_ChIP-Seq_THP-1_Human1.30857445
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.30462780
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29975143
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.28152231
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26739461
80ERA_21632823_ChIP-Seq_H3396_Human1.26052004
81PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.24744256
82TP53_22127205_ChIP-Seq_IMR90_Human1.24266193
83OCT4_20526341_ChIP-Seq_ESCs_Human1.24023665
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22659870
85TAF2_19829295_ChIP-Seq_ESCs_Human1.21567349
86SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.20441094
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17796276
88SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17147020
89CTCF_20526341_ChIP-Seq_ESCs_Human1.17055362
90FOXH1_21741376_ChIP-Seq_ESCs_Human1.16547417
91TET1_21451524_ChIP-Seq_MESCs_Mouse1.16342461
92* NANOG_20526341_ChIP-Seq_ESCs_Human1.15693800
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15524777
94TFEB_21752829_ChIP-Seq_HELA_Human1.15018520
95CTCF_21964334_ChIP-Seq_BJAB-B_Human1.14937066
96TBX5_21415370_ChIP-Seq_HL-1_Mouse1.14592909
97* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14392999
98FOXP1_21924763_ChIP-Seq_HESCs_Human1.12792742
99* SA1_27219007_Chip-Seq_Bcells_Human1.12397016
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12004602
101STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11727372
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.10219890
103ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10207270
104RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09980618
105ELK1_19687146_ChIP-ChIP_HELA_Human1.09232790
106EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09027808
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08694180
108BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08684140
109* SPI1_23547873_ChIP-Seq_NB4_Human1.08647248
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08349840
111RAC3_21632823_ChIP-Seq_H3396_Human1.07778673
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07385633
113PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06670192
114SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06589796
115FLI1_21867929_ChIP-Seq_CD8_Mouse1.06361942
116FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06166800
117* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06165789
118IRF1_19129219_ChIP-ChIP_H3396_Human1.05671245
119* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04827174
120CTCF_21964334_Chip-Seq_Bcells_Human1.04458910
121NCOR_22424771_ChIP-Seq_293T_Human1.03862635
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03825262
123TP63_19390658_ChIP-ChIP_HaCaT_Human1.03291507
124GATA3_21878914_ChIP-Seq_MCF-7_Human1.02772712
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01496096
126RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01440491
127YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00686782
128CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00482516
129EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99427906
130P53_21459846_ChIP-Seq_SAOS-2_Human0.99379005
131GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98086856
132CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97531655
133P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.97475723
134SOX2_22085726_ChIP-Seq_NPCs_Mouse0.97271982
135CTCF_26484167_Chip-Seq_Bcells_Mouse0.95302498
136CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95254322
137NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94950235
138* LXR_22292898_ChIP-Seq_THP-1_Human0.94817366
139MYC_18940864_ChIP-ChIP_HL60_Human0.94802328
140PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94800646
141CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94555050
142* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94356947
143* ETS1_21867929_ChIP-Seq_TH2_Mouse0.94293887
144* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93485943
145CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93331452
146KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.92526213
147TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92358295
148CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92139249
149GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90470124
150EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90132811
151RARA_24833708_ChIP-Seq_LIVER_Mouse0.89185846
152IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.87968487
153UTX_26944678_Chip-Seq_JUKART_Human0.87280419
154MYB_21317192_ChIP-Seq_ERMYB_Mouse0.86523842
155KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86349115
156MAF_26560356_Chip-Seq_TH1_Human0.85208150
157DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84953033
158* MAF_26560356_Chip-Seq_TH2_Human0.83459747
159GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82899197
160HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82532287
161CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.81567023
162ELK1_22589737_ChIP-Seq_MCF10A_Human0.81034292

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.04956154
2MP0004957_abnormal_blastocyst_morpholog4.01101567
3MP0003111_abnormal_nucleus_morphology3.75583380
4MP0005360_urolithiasis3.60873354
5MP0003077_abnormal_cell_cycle3.60800653
6MP0010094_abnormal_chromosome_stability3.42856462
7MP0005646_abnormal_pituitary_gland3.12382938
8MP0008057_abnormal_DNA_replication2.79000619
9MP0003303_peritoneal_inflammation2.75337530
10MP0000013_abnormal_adipose_tissue2.68853312
11MP0000566_synostosis2.59785036
12MP0006082_CNS_inflammation2.45050509
13MP0001986_abnormal_taste_sensitivity2.44091183
14MP0001661_extended_life_span2.34132289
15MP0002653_abnormal_ependyma_morphology2.32780862
16MP0003718_maternal_effect2.32148608
17MP0002736_abnormal_nociception_after2.28563543
18MP0004147_increased_porphyrin_level2.27607082
19MP0005670_abnormal_white_adipose2.25918970
20MP0003183_abnormal_peptide_metabolism2.23641867
21MP0003806_abnormal_nucleotide_metabolis2.17097288
22MP0008007_abnormal_cellular_replicative2.15737472
23MP0008872_abnormal_physiological_respon2.14479436
24MP0008058_abnormal_DNA_repair2.12887976
25MP0001764_abnormal_homeostasis2.10900385
26MP0000490_abnormal_crypts_of2.07583947
27MP0004043_abnormal_pH_regulation2.04510039
28MP0008932_abnormal_embryonic_tissue2.01687248
29MP0010352_gastrointestinal_tract_polyps1.97260761
30MP0000350_abnormal_cell_proliferation1.96266626
31MP0003724_increased_susceptibility_to1.96171649
32MP0001730_embryonic_growth_arrest1.92446619
33MP0004885_abnormal_endolymph1.91602421
34MP0001968_abnormal_touch/_nociception1.85975652
35MP0008875_abnormal_xenobiotic_pharmacok1.81988484
36MP0001873_stomach_inflammation1.81397627
37MP0002396_abnormal_hematopoietic_system1.80243361
38MP0009333_abnormal_splenocyte_physiolog1.80152793
39MP0005451_abnormal_body_composition1.79180358
40MP0009840_abnormal_foam_cell1.71369118
41MP0000516_abnormal_urinary_system1.69863121
42MP0005367_renal/urinary_system_phenotyp1.69863121
43MP0003786_premature_aging1.69600387
44MP0002938_white_spotting1.69405637
45MP0002095_abnormal_skin_pigmentation1.67964763
46MP0003195_calcinosis1.64359052
47MP0001663_abnormal_digestive_system1.63116596
48MP0002019_abnormal_tumor_incidence1.61331959
49MP0003186_abnormal_redox_activity1.57397251
50MP0003136_yellow_coat_color1.56382544
51MP0001545_abnormal_hematopoietic_system1.55050980
52MP0005397_hematopoietic_system_phenotyp1.55050980
53MP0003763_abnormal_thymus_physiology1.54256178
54MP0002876_abnormal_thyroid_physiology1.53895924
55MP0002138_abnormal_hepatobiliary_system1.53709421
56MP0005551_abnormal_eye_electrophysiolog1.51053922
57MP0001697_abnormal_embryo_size1.44632417
58MP0002398_abnormal_bone_marrow1.42700394
59MP0005332_abnormal_amino_acid1.41848336
60MP0002163_abnormal_gland_morphology1.41077515
61MP0001835_abnormal_antigen_presentation1.40872016
62MP0003436_decreased_susceptibility_to1.40781167
63MP0003123_paternal_imprinting1.39342112
64MP0004130_abnormal_muscle_cell1.38426035
65MP0000313_abnormal_cell_death1.35941425
66MP0002837_dystrophic_cardiac_calcinosis1.34549727
67MP0000685_abnormal_immune_system1.32967264
68MP0010307_abnormal_tumor_latency1.32304301
69MP0005380_embryogenesis_phenotype1.31197093
70MP0001672_abnormal_embryogenesis/_devel1.31197093
71MP0000003_abnormal_adipose_tissue1.29991268
72MP0002080_prenatal_lethality1.28051348
73MP0004808_abnormal_hematopoietic_stem1.27909355
74MP0001790_abnormal_immune_system1.26262120
75MP0005387_immune_system_phenotype1.26262120
76MP0000689_abnormal_spleen_morphology1.25703306
77MP0002722_abnormal_immune_system1.24905536
78MP0002210_abnormal_sex_determination1.24120984
79MP0002085_abnormal_embryonic_tissue1.22047820
80MP0008877_abnormal_DNA_methylation1.20831637
81MP0003646_muscle_fatigue1.20427081
82MP0000858_altered_metastatic_potential1.20359308
83MP0003656_abnormal_erythrocyte_physiolo1.20218278
84MP0002735_abnormal_chemical_nociception1.19913357
85MP0005671_abnormal_response_to1.17831437
86MP0001119_abnormal_female_reproductive1.16727017
87MP0001502_abnormal_circadian_rhythm1.16571195
88MP0001929_abnormal_gametogenesis1.16000097
89MP0001800_abnormal_humoral_immune1.15686513
90MP0003984_embryonic_growth_retardation1.14732297
91MP0002429_abnormal_blood_cell1.13702598
92MP0004142_abnormal_muscle_tone1.13370327
93MP0002405_respiratory_system_inflammati1.12443517
94MP0002088_abnormal_embryonic_growth/wei1.11368699
95MP0002102_abnormal_ear_morphology1.10550081
96MP0000703_abnormal_thymus_morphology1.09906429
97MP0002277_abnormal_respiratory_mucosa1.09029716
98MP0000716_abnormal_immune_system1.08125335
99MP0005310_abnormal_salivary_gland1.07943030
100MP0002452_abnormal_antigen_presenting1.06855340
101MP0005174_abnormal_tail_pigmentation1.06411187
102MP0002086_abnormal_extraembryonic_tissu1.05483573
103MP0002084_abnormal_developmental_patter1.04115268
104MP0000750_abnormal_muscle_regeneration1.03987818
105MP0001145_abnormal_male_reproductive1.03840990
106MP0000653_abnormal_sex_gland1.01885835
107MP0002723_abnormal_immune_serum1.01884179
108MP0002420_abnormal_adaptive_immunity1.00691082
109MP0001819_abnormal_immune_cell1.00481863
110MP0001915_intracranial_hemorrhage0.99836526
111MP0003315_abnormal_perineum_morphology0.99444272
112MP0005381_digestive/alimentary_phenotyp0.98792490
113MP0001348_abnormal_lacrimal_gland0.98369231
114MP0000358_abnormal_cell_content/0.96698357
115MP0005645_abnormal_hypothalamus_physiol0.96577226
116MP0005023_abnormal_wound_healing0.96037096
117MP0005000_abnormal_immune_tolerance0.92560081
118MP0005171_absent_coat_pigmentation0.91996939
119MP0009785_altered_susceptibility_to0.90962434
120MP0005025_abnormal_response_to0.90815880
121MP0009764_decreased_sensitivity_to0.90604681
122MP0009643_abnormal_urine_homeostasis0.89801776
123MP0005253_abnormal_eye_physiology0.89700205
124MP0000538_abnormal_urinary_bladder0.89528262
125MP0003699_abnormal_female_reproductive0.88536922
126MP0004197_abnormal_fetal_growth/weight/0.88292586
127MP0010030_abnormal_orbit_morphology0.88098148
128MP0001849_ear_inflammation0.87911294
129MP0001944_abnormal_pancreas_morphology0.86519297
130MP0005083_abnormal_biliary_tract0.86220644
131MP0008995_early_reproductive_senescence0.86070688
132MP0001853_heart_inflammation0.85502688
133MP0001664_abnormal_digestion0.85239682
134MP0004381_abnormal_hair_follicle0.85164164
135MP0000026_abnormal_inner_ear0.85129503
136MP0001270_distended_abdomen0.84981751
137MP0004133_heterotaxia0.84510132
138MP0000470_abnormal_stomach_morphology0.84380425
139MP0005395_other_phenotype0.83999901
140MP0002132_abnormal_respiratory_system0.83102996
141MP0003045_fibrosis0.82723811
142MP0001756_abnormal_urination0.81979063
143MP0002160_abnormal_reproductive_system0.81422553
144MP0002693_abnormal_pancreas_physiology0.81220765
145MP0000371_diluted_coat_color0.81217438
146MP0000534_abnormal_ureter_morphology0.80737001
147MP0005389_reproductive_system_phenotype0.80024331
148MP0008260_abnormal_autophagy0.79244212
149MP0003705_abnormal_hypodermis_morpholog0.78677292
150MP0000477_abnormal_intestine_morphology0.78661002
151MP0005621_abnormal_cell_physiology0.77928002
152MP0005464_abnormal_platelet_physiology0.77226922
153MP0000647_abnormal_sebaceous_gland0.77158032
154MP0002419_abnormal_innate_immunity0.77055016
155MP0006292_abnormal_olfactory_placode0.76847365
156MP0001845_abnormal_inflammatory_respons0.76183686
157MP0004145_abnormal_muscle_electrophysio0.76151887
158MP0003453_abnormal_keratinocyte_physiol0.75983456
159MP0008469_abnormal_protein_level0.73075290
160MP0009278_abnormal_bone_marrow0.71484034
161MP0005384_cellular_phenotype0.70932799
162MP0010155_abnormal_intestine_physiology0.70908086
163MP0006036_abnormal_mitochondrial_physio0.70071179
164MP0000598_abnormal_liver_morphology0.69909798
165MP0001919_abnormal_reproductive_system0.69876161
166MP0005076_abnormal_cell_differentiation0.68261128
167MP0002148_abnormal_hypersensitivity_rea0.67262950
168MP0003566_abnormal_cell_adhesion0.66635869

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)7.47730621
2Abnormality of alanine metabolism (HP:0010916)7.47730621
3Hyperalaninemia (HP:0003348)7.47730621
4Constricted visual fields (HP:0001133)5.02130753
5Congenital sensorineural hearing impairment (HP:0008527)4.88128414
6Birth length less than 3rd percentile (HP:0003561)4.64482620
7Decreased electroretinogram (ERG) amplitude (HP:0000654)4.20849097
8Duplicated collecting system (HP:0000081)4.18523510
9Abnormality of cells of the erythroid lineage (HP:0012130)3.99920908
10Breast hypoplasia (HP:0003187)3.98695877
11Oral leukoplakia (HP:0002745)3.90970117
12Abnormal number of erythroid precursors (HP:0012131)3.84843450
13Abnormality of the renal collecting system (HP:0004742)3.78202156
14Reticulocytopenia (HP:0001896)3.75924091
15Attenuation of retinal blood vessels (HP:0007843)3.62494621
16Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.58617802
17Aplastic anemia (HP:0001915)3.47407699
18Homocystinuria (HP:0002156)3.47219776
19Abnormality of homocysteine metabolism (HP:0010919)3.47219776
20Large for gestational age (HP:0001520)3.39330456
21Microretrognathia (HP:0000308)3.38722242
22Patellar aplasia (HP:0006443)3.35436885
23Chromsome breakage (HP:0040012)3.34813324
24Spontaneous hematomas (HP:0007420)3.34108776
25Anorexia (HP:0002039)3.28931318
26Carpal bone hypoplasia (HP:0001498)3.25727231
27Chromosomal breakage induced by crosslinking agents (HP:0003221)3.22387096
28Aplasia/Hypoplasia of the patella (HP:0006498)3.16773096
29Single umbilical artery (HP:0001195)3.06913727
30Abnormality of the fetal cardiovascular system (HP:0010948)3.06913727
31Abnormal umbilical cord blood vessels (HP:0011403)3.06913727
32Rough bone trabeculation (HP:0100670)3.05469078
33Chronic hepatic failure (HP:0100626)3.02470281
34Congenital stationary night blindness (HP:0007642)3.00859213
35Premature ovarian failure (HP:0008209)3.00046305
36Multiple enchondromatosis (HP:0005701)2.97259374
37White forelock (HP:0002211)2.97132362
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.93050634
39Secondary amenorrhea (HP:0000869)2.92564931
40Abnormality of the anterior horn cell (HP:0006802)2.88414733
41Degeneration of anterior horn cells (HP:0002398)2.88414733
42Pendular nystagmus (HP:0012043)2.86309868
43Cerebral hypomyelination (HP:0006808)2.83409552
44Chorioretinal atrophy (HP:0000533)2.80293721
45Esophageal varix (HP:0002040)2.67352473
46Thrombocytosis (HP:0001894)2.66393059
47Patchy hypopigmentation of hair (HP:0011365)2.59464205
48Abnormality of pyrimidine metabolism (HP:0004353)2.59202418
49Pancreatic cysts (HP:0001737)2.56051752
50Abnormality of the preputium (HP:0100587)2.55906358
51Selective tooth agenesis (HP:0001592)2.55029864
52Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.54528864
53Myelodysplasia (HP:0002863)2.53605358
54Generalized aminoaciduria (HP:0002909)2.53387505
55Increased serum lactate (HP:0002151)2.48869277
56Male infertility (HP:0003251)2.47555174
57Brushfield spots (HP:0001088)2.45977950
58Amaurosis fugax (HP:0100576)2.43206873
59Decreased activity of mitochondrial respiratory chain (HP:0008972)2.41333423
60Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.41333423
61Meckel diverticulum (HP:0002245)2.40860262
62Elevated erythrocyte sedimentation rate (HP:0003565)2.39196346
63Absent thumb (HP:0009777)2.37911782
64Bone marrow hypocellularity (HP:0005528)2.36923621
65Trismus (HP:0000211)2.35717028
66Pallor (HP:0000980)2.34232498
67Abnormality of serum amino acid levels (HP:0003112)2.34028464
68Chronic otitis media (HP:0000389)2.33944092
69Ureteral duplication (HP:0000073)2.32084381
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.32035442
71Neoplasm of the pancreas (HP:0002894)2.30418050
72Macrocytic anemia (HP:0001972)2.29494232
73Abnormality of the ileum (HP:0001549)2.29238099
74Pulmonary embolism (HP:0002204)2.28430577
75Pancytopenia (HP:0001876)2.23907841
76Muscle fiber atrophy (HP:0100295)2.23722000
77Lactic acidosis (HP:0003128)2.23468272
78Abnormality of chromosome stability (HP:0003220)2.22537895
79Agnosia (HP:0010524)2.20596555
80Absent radius (HP:0003974)2.19164198
81Colon cancer (HP:0003003)2.18405259
82Molar tooth sign on MRI (HP:0002419)2.18245930
83Abnormality of midbrain morphology (HP:0002418)2.18245930
84Abnormality of sulfur amino acid metabolism (HP:0004339)2.17763697
85Hypoplasia of the uterus (HP:0000013)2.17191328
86Severe muscular hypotonia (HP:0006829)2.17040545
87Poor speech (HP:0002465)2.15326339
88Abnormal trabecular bone morphology (HP:0100671)2.13323406
89Myopathic facies (HP:0002058)2.12301248
90Type II lissencephaly (HP:0007260)2.12185935
91Pancreatic fibrosis (HP:0100732)2.11832513
92Abnormality of fatty-acid metabolism (HP:0004359)2.11671543
93Brittle hair (HP:0002299)2.10117720
94Impulsivity (HP:0100710)2.09946529
95Premature graying of hair (HP:0002216)2.09563100
96Pustule (HP:0200039)2.07693886
97Pulmonary fibrosis (HP:0002206)2.07552368
98Concave nail (HP:0001598)2.07366355
99Ileus (HP:0002595)2.04979621
100Myocardial infarction (HP:0001658)2.04793345
101Reduced subcutaneous adipose tissue (HP:0003758)2.04088650
102Fatigue (HP:0012378)2.03270772
103Type 2 muscle fiber atrophy (HP:0003554)2.03032484
104Nasal polyposis (HP:0100582)2.02133076
105Aplasia involving forearm bones (HP:0009822)2.01450874
106Absent forearm bone (HP:0003953)2.01450874
107Tetany (HP:0001281)2.01431167
108Rib fusion (HP:0000902)2.00408462
109Myositis (HP:0100614)1.99310146
110Metabolic acidosis (HP:0001942)1.98340101
111Cleft eyelid (HP:0000625)1.98262206
112Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.96536965
113Supernumerary spleens (HP:0009799)1.96052343
114Hemoptysis (HP:0002105)1.94716907
115Tracheoesophageal fistula (HP:0002575)1.93554435
116Nausea (HP:0002018)1.92617570
117Cellular immunodeficiency (HP:0005374)1.92168620
118Medulloblastoma (HP:0002885)1.92161762
119Aplasia/Hypoplasia of the sacrum (HP:0008517)1.88777239
120Horseshoe kidney (HP:0000085)1.88347745
121Personality changes (HP:0000751)1.86278214
122Exertional dyspnea (HP:0002875)1.84902879
123Duodenal stenosis (HP:0100867)1.84675739
124Small intestinal stenosis (HP:0012848)1.84675739
125True hermaphroditism (HP:0010459)1.84322763
126Aplasia/hypoplasia of the uterus (HP:0008684)1.84050477
127Recurrent bacterial skin infections (HP:0005406)1.82952982
128Cheilitis (HP:0100825)1.82745910
129Tongue fasciculations (HP:0001308)1.81556197
130Sloping forehead (HP:0000340)1.81134278
131IgM deficiency (HP:0002850)1.81089990
132Abnormality of the umbilical cord (HP:0010881)1.80537651
133Progressive muscle weakness (HP:0003323)1.80102292
134Sparse eyelashes (HP:0000653)1.80035773
135Hypertensive crisis (HP:0100735)1.79999948
136Inability to walk (HP:0002540)1.79996041
137Anencephaly (HP:0002323)1.79937893
138Abnormality of DNA repair (HP:0003254)1.79898731
139Facial hemangioma (HP:0000329)1.79511369
140Rhabdomyosarcoma (HP:0002859)1.79372006
141Irregular epiphyses (HP:0010582)1.78214416
142Eczematoid dermatitis (HP:0000976)1.77452354
143Decreased subcutaneous fat (HP:0001002)1.77303974
144Lymphoma (HP:0002665)1.74313419
145Long foot (HP:0001833)1.74241437
146Progressive microcephaly (HP:0000253)1.74121404
147Mesangial abnormality (HP:0001966)1.74004900
148Abnormality of the nasal mucosa (HP:0000433)1.71161088
149Basal cell carcinoma (HP:0002671)1.71066873
150Hypergonadotropic hypogonadism (HP:0000815)1.70385044
151Abnormal rod and cone electroretinograms (HP:0008323)1.69520093
152Increased serum ferritin (HP:0003281)1.69377121
153Recurrent abscess formation (HP:0002722)1.69241439
154Petechiae (HP:0000967)1.68827935
155Abnormal spermatogenesis (HP:0008669)1.68734500
156Arterial thrombosis (HP:0004420)1.67740227
157Cortical visual impairment (HP:0100704)1.67124131
158Triphalangeal thumb (HP:0001199)1.66274162
159Hypomagnesemia (HP:0002917)1.65979702
160Conjunctival telangiectasia (HP:0000524)1.65855126
161Pigmentary retinal degeneration (HP:0001146)1.65716590
162Conical tooth (HP:0000698)1.65288970
163Abnormality of the carotid arteries (HP:0005344)1.64884015
164Type II diabetes mellitus (HP:0005978)1.64625778
165Clubbing of toes (HP:0100760)1.63714604
166Leukopenia (HP:0001882)1.63553016
167Abnormality of the fingertips (HP:0001211)1.63200477
168Stomatitis (HP:0010280)1.62693485
169Progressive inability to walk (HP:0002505)1.62352455
170CNS hypomyelination (HP:0003429)1.61904123
171Abnormality of reticulocytes (HP:0004312)1.61446106
172Tubular atrophy (HP:0000092)1.61353130
173Aseptic necrosis (HP:0010885)1.59931322
174Toxemia of pregnancy (HP:0100603)1.59881310
175Recurrent viral infections (HP:0004429)1.59851810
176Cafe-au-lait spot (HP:0000957)1.59344263
177Gastrointestinal infarctions (HP:0005244)1.59233727
178Hypoplasia of the pons (HP:0012110)1.58956628
179Abnormal number of incisors (HP:0011064)1.58580882
180Oligomenorrhea (HP:0000876)1.58301743
181Squamous cell carcinoma (HP:0002860)1.57579441
182Abnormality of T cell physiology (HP:0011840)1.57435705
183Hypoplasia of the capital femoral epiphysis (HP:0003090)1.56283871
184Death in infancy (HP:0001522)1.56229935
185Abnormal drinking behavior (HP:0030082)1.55589208
186Polydipsia (HP:0001959)1.55589208
187Abnormality of the duodenum (HP:0002246)1.55457936
188Overlapping toe (HP:0001845)1.55384054
189Atresia of the external auditory canal (HP:0000413)1.55013442
190Reduced antithrombin III activity (HP:0001976)1.54987669

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK26.07094125
2BUB14.26925058
3CDC72.94275049
4TAOK22.91885744
5MKNK12.86766563
6WEE12.66597628
7NME22.64216921
8NEK22.54963376
9PLK42.45843750
10EEF2K2.36007214
11FRK2.35440839
12ACVR1B2.32057935
13RPS6KA42.27364123
14ADRBK22.15213378
15MAP4K12.11540453
16ZAK2.11514264
17TESK22.11354634
18TTK1.94388263
19BRAF1.92262973
20DYRK31.90854140
21EIF2AK11.75599439
22FGR1.63542744
23MAP3K101.63328808
24PLK11.63091283
25PIM21.62137063
26MAPKAPK31.57238232
27CDK71.55384900
28LATS11.53143917
29RPS6KB21.51068932
30MAP3K111.47648655
31SRPK11.47519118
32STK101.46116504
33MAP3K81.43779727
34CHEK21.41286938
35TXK1.39227798
36CDK41.39045661
37MAP3K61.38805025
38ARAF1.38028030
39CDK81.36993569
40WNK41.35840040
41TAOK11.32730983
42AURKB1.28764557
43TYK21.28177303
44ADRBK11.26025252
45VRK11.24975649
46AURKA1.23895091
47ERN11.23305736
48EPHA31.22981828
49CDK91.22415296
50PINK11.17411882
51VRK21.15631963
52GRK11.14760173
53LATS21.12495454
54PIM11.11175109
55ATR1.10792147
56RAF11.08930099
57MAP3K31.07871394
58CCNB11.06601636
59STK161.03095812
60SCYL21.01776225
61DYRK20.99883645
62MAP2K30.98352627
63KDR0.98262873
64ABL20.95451389
65NTRK20.93522261
66BRSK10.93386070
67BRSK20.91938675
68PRKCQ0.91570113
69JAK30.90165077
70EIF2AK30.88175466
71BLK0.87614250
72EPHA20.87536221
73ERBB40.85086795
74CHEK10.84518534
75SGK2230.84463348
76SGK4940.84463348
77IRAK40.82440715
78MUSK0.82415871
79MAP3K130.82137077
80CDK120.82038345
81TLK10.81513710
82STK40.81440096
83PAK40.79944583
84CAMKK20.78560966
85MELK0.77260928
86MOS0.76942619
87TBK10.76397698
88ZAP700.76017136
89STK30.74826292
90PBK0.72754073
91KSR20.72570336
92SYK0.72311624
93LRRK20.71987546
94SIK20.71570115
95TSSK60.71246921
96STK38L0.70470463
97TESK10.70071979
98CSNK1A10.69106136
99TGFBR10.68772835
100PRKCI0.66259599
101CAMKK10.65500703
102IKBKB0.65347701
103MAPK110.65297790
104MAPK150.65246944
105PASK0.64239031
106PAK10.64201233
107NEK10.63518080
108NLK0.62980105
109BTK0.61493100
110INSRR0.61488106
111MARK30.60914787
112GRK60.59658161
113CHUK0.59654889
114TAOK30.59274106
115DYRK1A0.58216749
116PKN20.58158477
117DAPK20.58047538
118RPS6KA50.58016929
119FLT30.57732456
120MAP2K60.56824411
121TRIB30.54520340
122ITK0.53992844
123CDK20.53294656
124PHKG20.52843498
125PHKG10.52843498
126MAP3K10.51188539
127MAP2K10.51141857
128NME10.50227839
129KIT0.49444148
130TNK20.49086068
131RPS6KA60.47431442
132IKBKE0.47150859
133IRAK30.47122629
134NTRK30.46318116
135PLK30.45335875
136ATM0.45022738
137CDK60.43925679
138LCK0.43470197
139BCKDK0.41950652
140CSNK2A10.41334221
141LYN0.40593172
142MAP3K140.39964436
143EPHB20.39460207
144DYRK1B0.37752504
145RPS6KA10.37430907
146MAP2K20.37025022
147MAP3K50.35612275
148SGK20.35532566
149PRKCD0.34944914
150GRK70.33362854
151SIK30.31125333
152MAPK130.30783394
153PTK60.29254211
154HIPK20.27936482
155MAP4K20.27670343
156STK110.25987969
157BRD40.24772110
158BMPR1B0.23848268
159CAMK10.22619609
160RPS6KB10.21380973

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.37215653
2Mismatch repair_Homo sapiens_hsa034303.48885037
3RNA polymerase_Homo sapiens_hsa030203.33151979
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.17347269
5Base excision repair_Homo sapiens_hsa034102.97143849
6Ribosome_Homo sapiens_hsa030102.91858729
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.83159107
8Proteasome_Homo sapiens_hsa030502.78569571
9Cell cycle_Homo sapiens_hsa041102.70467983
10RNA transport_Homo sapiens_hsa030132.65048263
11Spliceosome_Homo sapiens_hsa030402.59346433
12Homologous recombination_Homo sapiens_hsa034402.55348957
13Pyrimidine metabolism_Homo sapiens_hsa002402.50413518
14Collecting duct acid secretion_Homo sapiens_hsa049662.44386147
15SNARE interactions in vesicular transport_Homo sapiens_hsa041302.37405766
16Nucleotide excision repair_Homo sapiens_hsa034202.37203746
17One carbon pool by folate_Homo sapiens_hsa006702.35013020
18Sulfur metabolism_Homo sapiens_hsa009202.32714700
19Maturity onset diabetes of the young_Homo sapiens_hsa049502.22546349
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.08944406
21Basal transcription factors_Homo sapiens_hsa030221.97372477
22Nitrogen metabolism_Homo sapiens_hsa009101.95334562
23RNA degradation_Homo sapiens_hsa030181.86910143
24Folate biosynthesis_Homo sapiens_hsa007901.78123175
25Asthma_Homo sapiens_hsa053101.72598908
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.71509404
27Fanconi anemia pathway_Homo sapiens_hsa034601.65373926
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61209134
29Oxidative phosphorylation_Homo sapiens_hsa001901.58313836
30Autoimmune thyroid disease_Homo sapiens_hsa053201.57476706
31p53 signaling pathway_Homo sapiens_hsa041151.57265022
32Arginine biosynthesis_Homo sapiens_hsa002201.48558686
33Butanoate metabolism_Homo sapiens_hsa006501.47652199
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39173628
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.39004759
36Morphine addiction_Homo sapiens_hsa050321.35591151
37Non-homologous end-joining_Homo sapiens_hsa034501.30998558
38Graft-versus-host disease_Homo sapiens_hsa053321.30509094
39Sulfur relay system_Homo sapiens_hsa041221.27528386
40Nicotine addiction_Homo sapiens_hsa050331.25481387
41Phototransduction_Homo sapiens_hsa047441.21725454
42mRNA surveillance pathway_Homo sapiens_hsa030151.21473247
43Epstein-Barr virus infection_Homo sapiens_hsa051691.21457082
44Vitamin B6 metabolism_Homo sapiens_hsa007501.19268730
45Herpes simplex infection_Homo sapiens_hsa051681.18498221
46Regulation of autophagy_Homo sapiens_hsa041401.17687062
47Ether lipid metabolism_Homo sapiens_hsa005651.17670380
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16344357
49Purine metabolism_Homo sapiens_hsa002301.14870479
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13138647
51Vitamin digestion and absorption_Homo sapiens_hsa049771.12281927
52Selenocompound metabolism_Homo sapiens_hsa004501.10662177
53Taste transduction_Homo sapiens_hsa047421.10184412
54Rheumatoid arthritis_Homo sapiens_hsa053231.07813300
55Pentose phosphate pathway_Homo sapiens_hsa000301.07654934
56GABAergic synapse_Homo sapiens_hsa047270.97523274
57Tryptophan metabolism_Homo sapiens_hsa003800.97330837
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95980373
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.94429082
60Biosynthesis of amino acids_Homo sapiens_hsa012300.94064587
61Peroxisome_Homo sapiens_hsa041460.93825697
62Type I diabetes mellitus_Homo sapiens_hsa049400.93352911
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91804207
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90418273
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89834095
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88718164
67Antigen processing and presentation_Homo sapiens_hsa046120.83916849
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.82703344
69Caffeine metabolism_Homo sapiens_hsa002320.82665476
70Viral carcinogenesis_Homo sapiens_hsa052030.81443834
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80469948
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.79997081
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.79865041
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79844205
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74441678
76ABC transporters_Homo sapiens_hsa020100.73861398
77Protein export_Homo sapiens_hsa030600.73400783
78Glutathione metabolism_Homo sapiens_hsa004800.72904613
79Shigellosis_Homo sapiens_hsa051310.72364589
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72158525
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71613796
82Parkinsons disease_Homo sapiens_hsa050120.71559292
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71497560
84HTLV-I infection_Homo sapiens_hsa051660.68826828
85Apoptosis_Homo sapiens_hsa042100.68762278
86Systemic lupus erythematosus_Homo sapiens_hsa053220.66471510
87Small cell lung cancer_Homo sapiens_hsa052220.66274573
88Legionellosis_Homo sapiens_hsa051340.65002232
89Glycerolipid metabolism_Homo sapiens_hsa005610.64995462
90Thyroid cancer_Homo sapiens_hsa052160.64707520
91Bladder cancer_Homo sapiens_hsa052190.64168625
92Primary immunodeficiency_Homo sapiens_hsa053400.63842469
93Acute myeloid leukemia_Homo sapiens_hsa052210.61029087
94Measles_Homo sapiens_hsa051620.58961990
95Linoleic acid metabolism_Homo sapiens_hsa005910.56527609
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56097563
97Hepatitis B_Homo sapiens_hsa051610.55755225
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55539871
99Chronic myeloid leukemia_Homo sapiens_hsa052200.53647714
100Notch signaling pathway_Homo sapiens_hsa043300.51720663
101Leishmaniasis_Homo sapiens_hsa051400.51568215
102Oocyte meiosis_Homo sapiens_hsa041140.51179681
103Pancreatic cancer_Homo sapiens_hsa052120.51119559
104MicroRNAs in cancer_Homo sapiens_hsa052060.49948630
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49618042
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49252215
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48315747
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48294125
109Influenza A_Homo sapiens_hsa051640.48081678
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47170188
111Arginine and proline metabolism_Homo sapiens_hsa003300.45691698
112Olfactory transduction_Homo sapiens_hsa047400.45429409
113T cell receptor signaling pathway_Homo sapiens_hsa046600.45307590
114Colorectal cancer_Homo sapiens_hsa052100.43514656
115Other glycan degradation_Homo sapiens_hsa005110.41919359
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.41866698
117Synaptic vesicle cycle_Homo sapiens_hsa047210.41167412
118Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40450826
119TGF-beta signaling pathway_Homo sapiens_hsa043500.40199426
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38836753
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37425237
122Serotonergic synapse_Homo sapiens_hsa047260.37210567
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37012888
124B cell receptor signaling pathway_Homo sapiens_hsa046620.36370436
125Carbon metabolism_Homo sapiens_hsa012000.36175812
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34379861
127Cholinergic synapse_Homo sapiens_hsa047250.33645242
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33552179
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32851218
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32785944
131Galactose metabolism_Homo sapiens_hsa000520.32707870
132Sphingolipid metabolism_Homo sapiens_hsa006000.32399946
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29391569
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29175750
135Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28971686
136Retinol metabolism_Homo sapiens_hsa008300.28942881
137Jak-STAT signaling pathway_Homo sapiens_hsa046300.28724949
138Fatty acid biosynthesis_Homo sapiens_hsa000610.28329797
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27808851
140TNF signaling pathway_Homo sapiens_hsa046680.24500234
141Metabolic pathways_Homo sapiens_hsa011000.24225390
142Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.23739586
143Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23704677
144Huntingtons disease_Homo sapiens_hsa050160.22980617
145Toxoplasmosis_Homo sapiens_hsa051450.20763861
146Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20719639
147Hematopoietic cell lineage_Homo sapiens_hsa046400.19511520
148Allograft rejection_Homo sapiens_hsa053300.19392992
149Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19359265
150Prolactin signaling pathway_Homo sapiens_hsa049170.19032368
151Fructose and mannose metabolism_Homo sapiens_hsa000510.18807233
152Arachidonic acid metabolism_Homo sapiens_hsa005900.18499723

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