GPNMB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.96427723
2positive regulation by organism of defense response of other organism involved in symbiotic interact7.96427723
3modulation by symbiont of host immune response (GO:0052553)7.96427723
4positive regulation by symbiont of host defense response (GO:0052509)7.96427723
5modulation by symbiont of host defense response (GO:0052031)7.96427723
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.96427723
7oligosaccharide catabolic process (GO:0009313)6.98982544
8regulation of interferon-beta biosynthetic process (GO:0045357)6.21230227
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.12744934
10amino sugar catabolic process (GO:0046348)5.79699421
11neutrophil activation involved in immune response (GO:0002283)5.79552194
12ceramide catabolic process (GO:0046514)5.61890283
13macrophage activation involved in immune response (GO:0002281)5.39447477
14positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.31711523
15response to host immune response (GO:0052572)5.02141880
16response to immune response of other organism involved in symbiotic interaction (GO:0052564)5.02141880
17positive regulation of interferon-alpha production (GO:0032727)4.75647081
18regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.64631533
19regulation of interferon-alpha production (GO:0032647)4.56225574
20response to host (GO:0075136)4.47484226
21response to host defenses (GO:0052200)4.47484226
22response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.47484226
23positive regulation of antigen processing and presentation (GO:0002579)4.46397357
24regulation of mononuclear cell migration (GO:0071675)4.41040279
25respiratory burst (GO:0045730)4.29617763
26membrane lipid catabolic process (GO:0046466)4.27813486
27sphingolipid catabolic process (GO:0030149)4.21874063
28positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.15623842
29negative regulation of interleukin-12 production (GO:0032695)4.14270969
30immunoglobulin mediated immune response (GO:0016064)4.12360917
31response to peptidoglycan (GO:0032494)4.08584168
32positive regulation of monocyte chemotaxis (GO:0090026)4.05852046
33regulation of B cell receptor signaling pathway (GO:0050855)4.05201297
34N-acetylneuraminate metabolic process (GO:0006054)4.04498324
35microglial cell activation (GO:0001774)3.98070009
36cellular response to thyroid hormone stimulus (GO:0097067)3.98011419
37myeloid cell activation involved in immune response (GO:0002275)3.97009643
38negative regulation of nitric oxide biosynthetic process (GO:0045019)3.96069996
39macrophage activation (GO:0042116)3.83288380
40phagosome maturation (GO:0090382)3.77904775
41positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.75752088
42granulocyte activation (GO:0036230)3.74607428
43barbed-end actin filament capping (GO:0051016)3.68922429
44regulation of cholesterol storage (GO:0010885)3.66667714
45natural killer cell mediated cytotoxicity (GO:0042267)3.63280456
46natural killer cell mediated immunity (GO:0002228)3.63280456
47regulation of antigen processing and presentation (GO:0002577)3.62563869
48regulation of interleukin-8 biosynthetic process (GO:0045414)3.62152872
49negative regulation of cell killing (GO:0031342)3.58282177
50negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.58282177
51pinocytosis (GO:0006907)3.55614896
52positive regulation of mast cell activation (GO:0033005)3.54982420
53low-density lipoprotein particle clearance (GO:0034383)3.54479595
54neutrophil activation (GO:0042119)3.53429521
55epithelial cell differentiation involved in prostate gland development (GO:0060742)3.53219535
56positive regulation of gamma-delta T cell activation (GO:0046645)3.45924946
57protein localization to endosome (GO:0036010)3.45913012
58neutrophil mediated immunity (GO:0002446)3.45482070
59negative regulation of mast cell activation (GO:0033004)3.43605105
60regulation of monocyte chemotaxis (GO:0090025)3.39644196
61ganglioside metabolic process (GO:0001573)3.38733121
62regulation of macrophage chemotaxis (GO:0010758)3.38611482
63adhesion of symbiont to host cell (GO:0044650)3.38525753
64virion attachment to host cell (GO:0019062)3.38525753
65positive regulation of interferon-beta production (GO:0032728)3.36021970
66positive regulation of cholesterol efflux (GO:0010875)3.34356271
67regulation of mast cell degranulation (GO:0043304)3.30572523
68melanin biosynthetic process (GO:0042438)3.30418950
69fat-soluble vitamin biosynthetic process (GO:0042362)3.29254888
70regulation of vitamin D biosynthetic process (GO:0060556)3.27602689
71glucosamine-containing compound catabolic process (GO:1901072)3.25711433
72positive regulation of chemokine biosynthetic process (GO:0045080)3.22970763
73osteoclast differentiation (GO:0030316)3.22726575
74T-helper 1 type immune response (GO:0042088)3.22693877
75response to thyroid hormone (GO:0097066)3.22542565
76regulation of mast cell activation (GO:0033003)3.19561129
77negative regulation of interleukin-17 production (GO:0032700)3.17891749
78lipopolysaccharide-mediated signaling pathway (GO:0031663)3.17744076
79positive regulation of cellular amide metabolic process (GO:0034250)3.16890219
80peptide catabolic process (GO:0043171)3.16842967
81I-kappaB phosphorylation (GO:0007252)3.14763425
82detection of molecule of bacterial origin (GO:0032490)3.13557735
83hyaluronan catabolic process (GO:0030214)3.12821689
84regulation of mast cell activation involved in immune response (GO:0033006)3.11112870
85positive regulation of leukocyte degranulation (GO:0043302)3.10033217
86monocyte chemotaxis (GO:0002548)3.09757587
87positive regulation of T cell apoptotic process (GO:0070234)3.09111428
88response to lipoprotein particle (GO:0055094)3.08584114
89regulation of leukocyte degranulation (GO:0043300)3.08450557
90lipoprotein transport (GO:0042953)3.07658221
91adhesion of symbiont to host (GO:0044406)3.07514152
92positive regulation of bone remodeling (GO:0046852)3.06871233
93positive regulation of bone resorption (GO:0045780)3.06871233
94glycosphingolipid catabolic process (GO:0046479)3.04418992
95response to muramyl dipeptide (GO:0032495)3.04132037
96positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.02621081
97intracellular pH reduction (GO:0051452)3.02608883
98lysosome organization (GO:0007040)3.01731980
99lytic vacuole organization (GO:0080171)3.01731980
100apoptotic cell clearance (GO:0043277)3.00208749
101melanin metabolic process (GO:0006582)3.00188728
102positive regulation of lymphocyte apoptotic process (GO:0070230)2.99801949
103regulation of chemokine-mediated signaling pathway (GO:0070099)2.97610487
104eosinophil chemotaxis (GO:0048245)2.96772405
105negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.96639766
106regulation of superoxide anion generation (GO:0032928)2.93722856
107glycosylceramide metabolic process (GO:0006677)2.90910491
108regulation of membrane protein ectodomain proteolysis (GO:0051043)2.90248012
109cell adhesion mediated by integrin (GO:0033627)2.89906207
110regulation of dendritic cell antigen processing and presentation (GO:0002604)2.89658395
111negative regulation of lipid storage (GO:0010888)2.88893785
112regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.88731432
113positive regulation of B cell differentiation (GO:0045579)2.88585291
114regulation of integrin activation (GO:0033623)2.88294802
115bone resorption (GO:0045453)2.88062228
116positive regulation of heat generation (GO:0031652)2.87740317
117positive regulation of sterol transport (GO:0032373)2.85816582
118positive regulation of cholesterol transport (GO:0032376)2.85816582
119L-alpha-amino acid transmembrane transport (GO:1902475)2.85768302
120positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.85689161
121plasma lipoprotein particle clearance (GO:0034381)2.85222983
122vitamin D metabolic process (GO:0042359)2.85095933
123B cell mediated immunity (GO:0019724)2.84669278
124positive regulation of mast cell activation involved in immune response (GO:0033008)2.84071828
125positive regulation of mast cell degranulation (GO:0043306)2.84071828
126mannose metabolic process (GO:0006013)2.83806675
127keratan sulfate catabolic process (GO:0042340)2.83512043
128defense response to protozoan (GO:0042832)2.82174859
129antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.81508248
130antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.81508248
131Arp2/3 complex-mediated actin nucleation (GO:0034314)2.81407602
132negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.80855570
133pH reduction (GO:0045851)2.79778146
134hydrogen peroxide biosynthetic process (GO:0050665)2.78769293
135interaction with host (GO:0051701)2.78739529
136myeloid leukocyte activation (GO:0002274)2.77837303
137negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.76299493
138myeloid dendritic cell differentiation (GO:0043011)2.76177656
139basic amino acid transport (GO:0015802)2.72625310
140semaphorin-plexin signaling pathway (GO:0071526)2.70895974
141positive regulation of macrophage cytokine production (GO:0060907)2.69783788
142glycolipid catabolic process (GO:0019377)2.69019840
143neutrophil chemotaxis (GO:0030593)2.68235359
144positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.68107314
145low-density lipoprotein particle remodeling (GO:0034374)2.67594597
146pigment cell differentiation (GO:0050931)2.67354464
147glial cell migration (GO:0008347)2.67079195
148negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.67033331
149iron ion import (GO:0097286)2.65714665
150response to acidic pH (GO:0010447)2.64697453
151secondary metabolite biosynthetic process (GO:0044550)2.63013880
152regulation of macrophage derived foam cell differentiation (GO:0010743)2.60400016
153detection of external biotic stimulus (GO:0098581)2.59484606
154lipid storage (GO:0019915)2.57283475
155phospholipid efflux (GO:0033700)2.56449570
156regulation of podosome assembly (GO:0071801)2.55614082
157detection of other organism (GO:0098543)2.54776571
158regulation of early endosome to late endosome transport (GO:2000641)2.54575586
159cellular response to arsenic-containing substance (GO:0071243)2.53733046
160regulation of vitamin metabolic process (GO:0030656)2.52532436
161transferrin transport (GO:0033572)2.50204908
162regulation of cytokine secretion involved in immune response (GO:0002739)2.49750722
163interferon-gamma-mediated signaling pathway (GO:0060333)2.49613844
164regulation of superoxide metabolic process (GO:0090322)2.47003288
165dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.46968263

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.95014306
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.88600575
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.74297847
4* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.78470235
5* IRF8_27001747_Chip-Seq_BMDM_Mouse4.70452911
6* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.68918612
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse4.16958412
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.31023705
9MYB_21317192_ChIP-Seq_ERMYB_Mouse3.22916724
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.20534580
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.75629635
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.72393185
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.64300829
14BRD4_27068464_Chip-Seq_AML-cells_Mouse2.60978014
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.56930649
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.56834754
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.54926305
18PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.35703913
19SPI1_23127762_ChIP-Seq_K562_Human2.23843657
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.18203465
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.16210286
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.13914441
23* SPI1_23547873_ChIP-Seq_NB4_Human2.05084843
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.04976015
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.99193076
26VDR_24787735_ChIP-Seq_THP-1_Human1.99181403
27* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.99052273
28PU_27001747_Chip-Seq_BMDM_Mouse1.95248863
29VDR_24763502_ChIP-Seq_THP-1_Human1.91568259
30VDR_21846776_ChIP-Seq_THP-1_Human1.87280639
31CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.84130414
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.84030026
33NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.80134961
34* TFEB_21752829_ChIP-Seq_HELA_Human1.79744415
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.79707123
36CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.72416321
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71530130
38CLOCK_20551151_ChIP-Seq_293T_Human1.70863250
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68356231
40PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64633387
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56062537
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.52272033
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45116559
44SCL_19346495_ChIP-Seq_HPC-7_Human1.44702009
45CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.43682503
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.40170965
47MAF_26560356_Chip-Seq_TH1_Human1.38715242
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37386678
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.35381925
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.35037797
51FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.33316973
52MYB_26560356_Chip-Seq_TH2_Human1.32507221
53* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29642660
54RUNX_20019798_ChIP-Seq_JUKART_Human1.29040215
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.28393816
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27714650
57PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27440829
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27365391
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27106611
60SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26999496
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22900892
62TCF7_22412390_ChIP-Seq_EML_Mouse1.22166662
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22117544
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22016319
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20535732
66CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19622876
67CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19607718
68NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17703765
69SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17235662
70LXR_22158963_ChIP-Seq_LIVER_Mouse1.16406922
71RXR_22158963_ChIP-Seq_LIVER_Mouse1.15877053
72CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14579713
73SOX2_20726797_ChIP-Seq_SW620_Human1.13804572
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13661519
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13053911
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12615146
77TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12472787
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11164012
79* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10632477
80MYB_26560356_Chip-Seq_TH1_Human1.10332740
81UTX_26944678_Chip-Seq_JUKART_Human1.09835273
82GATA1_22025678_ChIP-Seq_K562_Human1.09187202
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.08645375
84CJUN_26792858_Chip-Seq_BT549_Human1.08556555
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08031807
86TBX20_22080862_ChIP-Seq_HEART_Mouse1.07485431
87TBX20_22328084_ChIP-Seq_HEART_Mouse1.07485431
88* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05907205
89GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05174219
90GATA3_26560356_Chip-Seq_TH2_Human1.05055934
91KDM2B_26808549_Chip-Seq_DND41_Human1.04745925
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04500240
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03888869
94RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03827406
95SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03731985
96PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03561899
97P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03179481
98GATA3_27048872_Chip-Seq_THYMUS_Human1.02921611
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02334807
100* MITF_21258399_ChIP-Seq_MELANOMA_Human0.99804013
101LXR_22292898_ChIP-Seq_THP-1_Human0.99246964
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98756426
103GATA1_19941826_ChIP-Seq_K562_Human0.97538581
104PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95948744
105P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95811508
106GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95227376
107GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94436260
108TRIM28_21343339_ChIP-Seq_HEK293_Human0.92630370
109MYC_22102868_ChIP-Seq_BL_Human0.91893802
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91685789
111GATA1_19941827_ChIP-Seq_MEL_Mouse0.91489273
112NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90335282
113NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90335282
114RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89222983
115LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88820250
116TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87713757
117FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87143200
118UBF1/2_26484160_Chip-Seq_HMECs_Human0.86934488
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86838804
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86094471
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86008613
122GATA2_19941826_ChIP-Seq_K562_Human0.85189986
123GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84117045
124JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83046873
125ESR1_21235772_ChIP-Seq_MCF-7_Human0.81964611
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.80090069
127JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80065466
128PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79478352
129PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.76009263
130SPI1_20517297_ChIP-Seq_HL60_Human0.74485978
131* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.74169731

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology6.09910769
2MP0003172_abnormal_lysosome_physiology4.73657007
3MP0003303_peritoneal_inflammation4.34439198
4MP0000569_abnormal_digit_pigmentation4.19465475
5MP0006082_CNS_inflammation3.73376071
6MP0003436_decreased_susceptibility_to3.12850651
7MP0001835_abnormal_antigen_presentation3.03717472
8MP0002419_abnormal_innate_immunity2.79944491
9MP0009840_abnormal_foam_cell2.79346668
10MP0002877_abnormal_melanocyte_morpholog2.71832961
11MP0000604_amyloidosis2.54839064
12MP0005174_abnormal_tail_pigmentation2.43142189
13MP0005000_abnormal_immune_tolerance2.34543183
14MP0003690_abnormal_glial_cell2.33458104
15MP0003300_gastrointestinal_ulcer2.22802982
16MP0010307_abnormal_tumor_latency2.18991830
17MP0004510_myositis2.17778509
18MP0002452_abnormal_antigen_presenting2.07993230
19MP0003191_abnormal_cellular_cholesterol2.05547769
20MP0001790_abnormal_immune_system2.04215008
21MP0005387_immune_system_phenotype2.04215008
22MP0005464_abnormal_platelet_physiology2.03584278
23MP0005025_abnormal_response_to2.01599827
24MP0002139_abnormal_hepatobiliary_system1.96187347
25MP0009785_altered_susceptibility_to1.91543714
26MP0003329_amyloid_beta_deposits1.86092935
27MP0003448_altered_tumor_morphology1.84722766
28MP0002148_abnormal_hypersensitivity_rea1.84697239
29MP0000372_irregular_coat_pigmentation1.84451776
30MP0001533_abnormal_skeleton_physiology1.82174032
31MP0000015_abnormal_ear_pigmentation1.79961382
32MP0005451_abnormal_body_composition1.79179449
33MP0002723_abnormal_immune_serum1.74980603
34MP0004947_skin_inflammation1.72165612
35MP0001800_abnormal_humoral_immune1.71184299
36MP0001819_abnormal_immune_cell1.62543117
37MP0000371_diluted_coat_color1.61676714
38MP0002420_abnormal_adaptive_immunity1.60912108
39MP0006054_spinal_hemorrhage1.60451048
40MP0005310_abnormal_salivary_gland1.57383614
41MP0003566_abnormal_cell_adhesion1.57289131
42MP0002998_abnormal_bone_remodeling1.56275588
43MP0002405_respiratory_system_inflammati1.51430787
44MP0003183_abnormal_peptide_metabolism1.49558421
45MP0001958_emphysema1.48875205
46MP0000685_abnormal_immune_system1.48656625
47MP0009278_abnormal_bone_marrow1.42820448
48MP0003136_yellow_coat_color1.39050348
49MP0001845_abnormal_inflammatory_respons1.38691342
50MP0000343_altered_response_to1.36860076
51MP0003279_aneurysm1.36357953
52MP0002090_abnormal_vision1.35425813
53MP0004858_abnormal_nervous_system1.35324043
54MP0010386_abnormal_urinary_bladder1.32295145
55MP0005671_abnormal_response_to1.31151310
56MP0005167_abnormal_blood-brain_barrier1.30534958
57MP0003724_increased_susceptibility_to1.29246882
58MP0003705_abnormal_hypodermis_morpholog1.28522636
59MP0003656_abnormal_erythrocyte_physiolo1.27822690
60MP0003075_altered_response_to1.25073173
61MP0008469_abnormal_protein_level1.24410152
62MP0001851_eye_inflammation1.23994207
63MP0000858_altered_metastatic_potential1.23714055
64MP0008438_abnormal_cutaneous_collagen1.21758278
65MP0001542_abnormal_bone_strength1.17906982
66MP0000689_abnormal_spleen_morphology1.16441086
67MP0003806_abnormal_nucleotide_metabolis1.14069348
68MP0000716_abnormal_immune_system1.13757559
69MP0005275_abnormal_skin_tensile1.13524526
70MP0005166_decreased_susceptibility_to1.09701899
71MP0002933_joint_inflammation1.07223333
72MP0005171_absent_coat_pigmentation1.06536069
73MP0004381_abnormal_hair_follicle1.06256260
74MP0003634_abnormal_glial_cell1.05165798
75MP0005365_abnormal_bile_salt1.05112196
76MP0005083_abnormal_biliary_tract1.04818711
77MP0005165_increased_susceptibility_to1.02111383
78MP0003950_abnormal_plasma_membrane1.00570229
79MP0009333_abnormal_splenocyte_physiolog0.98988667
80MP0002398_abnormal_bone_marrow0.98595220
81MP0003632_abnormal_nervous_system0.97173590
82MP0000465_gastrointestinal_hemorrhage0.95915187
83MP0002722_abnormal_immune_system0.95040588
84MP0003091_abnormal_cell_migration0.93935472
85MP0000920_abnormal_myelination0.93253588
86MP0002429_abnormal_blood_cell0.92747836
87MP0010234_abnormal_vibrissa_follicle0.92688299
88MP0001545_abnormal_hematopoietic_system0.91550209
89MP0005397_hematopoietic_system_phenotyp0.91550209
90MP0005075_abnormal_melanosome_morpholog0.91082284
91MP0001853_heart_inflammation0.90945571
92MP0004883_abnormal_blood_vessel0.90662529
93MP0004019_abnormal_vitamin_homeostasis0.89580410
94MP0005248_abnormal_Harderian_gland0.88924859
95MP0010155_abnormal_intestine_physiology0.88427395
96MP0005408_hypopigmentation0.87465356
97* MP0005257_abnormal_intraocular_pressure0.87441882
98MP0001186_pigmentation_phenotype0.85509256
99MP0002896_abnormal_bone_mineralization0.85289033
100MP0005390_skeleton_phenotype0.85198558
101MP0008260_abnormal_autophagy0.82468074
102MP0009764_decreased_sensitivity_to0.82067236
103MP0008004_abnormal_stomach_pH0.79218818
104MP0002254_reproductive_system_inflammat0.78583396
105MP0004130_abnormal_muscle_cell0.78437518
106MP0005076_abnormal_cell_differentiation0.78238234
107MP0003795_abnormal_bone_structure0.78106070
108MP0003011_delayed_dark_adaptation0.75809386
109MP0002095_abnormal_skin_pigmentation0.75629627
110MP0005164_abnormal_response_to0.75343120
111* MP0005197_abnormal_uvea_morphology0.74233041
112MP0002166_altered_tumor_susceptibility0.74176450
113MP0010678_abnormal_skin_adnexa0.72763133
114MP0003828_pulmonary_edema0.67118141
115MP0004185_abnormal_adipocyte_glucose0.66417268
116MP0001849_ear_inflammation0.64031603
117MP0003453_abnormal_keratinocyte_physiol0.62029561
118MP0000249_abnormal_blood_vessel0.62002660
119MP0009763_increased_sensitivity_to0.61901080
120MP0000490_abnormal_crypts_of0.61304139
121MP0002006_tumorigenesis0.60509174
122MP0002075_abnormal_coat/hair_pigmentati0.58542711
123MP0005023_abnormal_wound_healing0.58195733
124MP0000733_abnormal_muscle_development0.58191677
125MP0004782_abnormal_surfactant_physiolog0.54870850
126MP0000598_abnormal_liver_morphology0.53212274

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)8.33262286
2Increased neuronal autofluorescent lipopigment (HP:0002074)6.67966030
3Vacuolated lymphocytes (HP:0001922)6.63785817
4Recurrent abscess formation (HP:0002722)5.88829757
5Abnormality of liposaccharide metabolism (HP:0010968)5.62616310
6Abnormality of glycosphingolipid metabolism (HP:0004343)5.62616310
7Abnormality of glycolipid metabolism (HP:0010969)5.62616310
8Dysostosis multiplex (HP:0000943)5.52393596
9Abnormality of macrophages (HP:0004311)5.13105907
10Urinary glycosaminoglycan excretion (HP:0003541)4.94882714
11Mucopolysacchariduria (HP:0008155)4.94882714
12Recurrent bacterial skin infections (HP:0005406)4.81516873
13Abnormality of mucopolysaccharide metabolism (HP:0011020)4.77648049
14Abnormality of polysaccharide metabolism (HP:0011012)4.77648049
15Abnormality of glycosaminoglycan metabolism (HP:0004371)4.77648049
16Recurrent gram-negative bacterial infections (HP:0005420)4.69436448
17Disinhibition (HP:0000734)4.69221743
18Eczematoid dermatitis (HP:0000976)4.60286090
19Axonal loss (HP:0003447)4.52354258
20Loss of speech (HP:0002371)4.20871979
21Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.93993855
22Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.86753477
23J-shaped sella turcica (HP:0002680)3.24642394
24Agnosia (HP:0010524)3.24446149
25Nuclear cataract (HP:0100018)3.23776260
26Gingivitis (HP:0000230)3.19911477
27Autoimmune thrombocytopenia (HP:0001973)3.15899179
28Myocardial infarction (HP:0001658)3.14122766
29Obstructive lung disease (HP:0006536)3.12439306
30Chronic obstructive pulmonary disease (HP:0006510)3.12439306
31Neuronal loss in central nervous system (HP:0002529)3.10571215
32Hepatosplenomegaly (HP:0001433)3.07360595
33Upper motor neuron abnormality (HP:0002127)3.03881230
34Global brain atrophy (HP:0002283)3.03074470
35Abnormality of the vasculature of the conjunctiva (HP:0008054)3.03069909
36Systemic lupus erythematosus (HP:0002725)3.02441851
37Mediastinal lymphadenopathy (HP:0100721)2.97347769
38Conjunctival telangiectasia (HP:0000524)2.89387612
39Asymmetric septal hypertrophy (HP:0001670)2.88616420
40Recurrent skin infections (HP:0001581)2.74028295
41Diminished motivation (HP:0000745)2.73573767
42Apathy (HP:0000741)2.69840728
43Peripheral demyelination (HP:0011096)2.64985575
44Supranuclear gaze palsy (HP:0000605)2.62764192
45Stomatitis (HP:0010280)2.59067550
46Pathologic fracture (HP:0002756)2.57595608
47Myositis (HP:0100614)2.56994523
48Purpura (HP:0000979)2.56852508
49Inappropriate behavior (HP:0000719)2.56487338
50Abnormality of the lumbar spine (HP:0100712)2.49144334
51Skin nodule (HP:0200036)2.48779703
52Increased CSF protein (HP:0002922)2.48032993
53Thoracic kyphosis (HP:0002942)2.46398595
54Basal ganglia calcification (HP:0002135)2.39833311
55Personality changes (HP:0000751)2.39514176
56Retinal atrophy (HP:0001105)2.36508307
57Orchitis (HP:0100796)2.35612946
58Dementia (HP:0000726)2.31414707
59Periodontitis (HP:0000704)2.29305403
60Bone pain (HP:0002653)2.28796884
61Prostate neoplasm (HP:0100787)2.24749975
62Mutism (HP:0002300)2.24636497
63Osteomyelitis (HP:0002754)2.22303916
64Recurrent fungal infections (HP:0002841)2.20223372
65Xanthomatosis (HP:0000991)2.20014878
66Cardiomegaly (HP:0001640)2.18765057
67Metaphyseal irregularity (HP:0003025)2.17224754
68White forelock (HP:0002211)2.16552672
69Prolonged neonatal jaundice (HP:0006579)2.15049534
70Neurofibrillary tangles (HP:0002185)2.14071667
71Ovoid vertebral bodies (HP:0003300)2.13935174
72Frequent falls (HP:0002359)2.10776219
73Urticaria (HP:0001025)2.10751590
74Beaking of vertebral bodies (HP:0004568)2.09639017
75Ocular albinism (HP:0001107)2.09399158
76Elevated erythrocyte sedimentation rate (HP:0003565)2.09013355
77Cellulitis (HP:0100658)2.08847467
78Tetraparesis (HP:0002273)2.07060643
79Interstitial pulmonary disease (HP:0006530)2.06225434
80Complement deficiency (HP:0004431)2.04543126
81Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.02757557
82Deformed sella turcica (HP:0002681)2.02753342
83Hypercholesterolemia (HP:0003124)2.01137258
84Neurodegeneration (HP:0002180)2.00438954
85Osteolytic defects of the phalanges of the hand (HP:0009771)1.97872350
86Osteolytic defects of the hand bones (HP:0009699)1.97872350
87Progressive neurologic deterioration (HP:0002344)1.97855683
88Retrobulbar optic neuritis (HP:0100654)1.97845096
89Optic neuritis (HP:0100653)1.97845096
90Patchy hypopigmentation of hair (HP:0011365)1.94787790
91Vertebral compression fractures (HP:0002953)1.93970000
92Thick nail (HP:0001805)1.93919036
93Glomerulonephritis (HP:0000099)1.93883487
94Mucosal telangiectasiae (HP:0100579)1.92604458
95Hematochezia (HP:0002573)1.90268668
96Protuberant abdomen (HP:0001538)1.88391642
97Poor head control (HP:0002421)1.88291635
98Abnormality of the thoracic spine (HP:0100711)1.87450326
99Epidermoid cyst (HP:0200040)1.86130301
100Spondylolisthesis (HP:0003302)1.84306845
101Pustule (HP:0200039)1.83060936
102Nausea (HP:0002018)1.81376639
103Premature loss of primary teeth (HP:0006323)1.80837871
104Joint hemorrhage (HP:0005261)1.79784024
105Vasculitis (HP:0002633)1.79281380
106Esophageal neoplasm (HP:0100751)1.78710632
107Neoplasm of head and neck (HP:0012288)1.78710632
108Cerebral inclusion bodies (HP:0100314)1.78710300
109Increased serum ferritin (HP:0003281)1.78464136
110Albinism (HP:0001022)1.77776389
111Absent frontal sinuses (HP:0002688)1.76842241
112Abnormality of complement system (HP:0005339)1.74433487
113Cervical subluxation (HP:0003308)1.73292698
114Spontaneous hematomas (HP:0007420)1.72236430
115Progressive visual loss (HP:0000529)1.71984012
116Abnormality of binocular vision (HP:0011514)1.71149270
117Diplopia (HP:0000651)1.71149270
118Recurrent viral infections (HP:0004429)1.70315697
119Multiple enchondromatosis (HP:0005701)1.68265104
120Generalized hypopigmentation (HP:0007513)1.68153604
121Abnormality of the periventricular white matter (HP:0002518)1.66631392
122Iris hypopigmentation (HP:0007730)1.66091629
123Spinal muscular atrophy (HP:0007269)1.60644700
124Pulmonary infiltrates (HP:0002113)1.58988249
125Multiple lipomas (HP:0001012)1.58964196
126Joint stiffness (HP:0001387)1.57453581
127Abnormality of the fovea (HP:0000493)1.57227909
128Segmental peripheral demyelination/remyelination (HP:0003481)1.56760151
129Amyloidosis (HP:0011034)1.56388365
130Polyneuropathy (HP:0001271)1.54927809

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KIT3.98746252
2DDR23.97248881
3RIPK43.62847854
4GRK73.42262445
5TBK13.36820941
6ACVR1B3.01355463
7PDK22.83380733
8ERN12.70497756
9TRIB32.62191401
10IRAK32.50947589
11PKN22.49999406
12BLK2.49565187
13TYK22.45251987
14IRAK42.24488511
15NME22.23514285
16MAP3K142.23495821
17SCYL22.21788360
18TTN2.09630066
19MAP4K11.94122133
20CAMK1D1.91616381
21FES1.84230255
22TAOK31.81386711
23CSF1R1.68612592
24PBK1.66397452
25CDC42BPA1.66062733
26BMX1.64017265
27NEK91.62904062
28IKBKE1.62507200
29FGR1.60212739
30HCK1.58617083
31TAOK21.57545233
32TGFBR21.54868529
33PRPF4B1.51792505
34PDGFRA1.50303355
35IKBKB1.49336195
36JAK11.48433735
37SYK1.46928186
38PTK61.46442555
39MAP3K131.40399811
40TGFBR11.39291453
41ADRBK21.38070403
42MST1R1.36772603
43ZAP701.35299370
44CAMKK21.34822650
45CAMK1G1.34635635
46ABL21.32919148
47RIPK11.32879298
48BMPR21.30295760
49CSK1.26597531
50JAK31.26445315
51EPHB11.24048063
52PAK41.15401848
53JAK21.12743260
54SIK21.12514456
55LCK1.11607912
56LYN1.09135209
57MARK31.07079126
58MAP2K31.06999717
59LRRK21.06734606
60CAMKK11.03815848
61EGFR1.00964710
62LATS20.97893576
63CDK120.97572656
64TRPM70.93974108
65STK100.89911566
66ABL10.89007575
67KSR20.88826163
68MAP3K30.87687165
69RPS6KA40.87094604
70PIM20.85951369
71CDK60.85909929
72BTK0.85680889
73TAOK10.83399288
74MOS0.83226842
75MAPK70.83137711
76STK240.78879459
77MAP2K60.78867126
78MAPK120.76499113
79SIK30.76387953
80CHUK0.75763517
81PRKCH0.74536749
82LIMK10.73954317
83MAPKAPK30.73404802
84PRKCD0.69058269
85FER0.67835476
86ITK0.67810534
87MATK0.67141672
88FYN0.64837336
89MAP3K50.64758247
90MAP3K60.64202633
91MAP3K110.63208071
92IRAK20.60387335
93ERBB40.60286123
94PDPK10.58432183
95TESK10.57360895
96ARAF0.57153599
97TESK20.55402221
98GRK60.54647043
99MYLK0.53899391
100MAP3K90.53692538
101TXK0.52830341
102PDGFRB0.51682085
103PRKD10.51037012
104SRC0.47721103
105TEC0.47586233
106DAPK20.47199039
107PIM10.46713192
108ALK0.45954938
109MAP3K20.45278592
110PDK10.45089934
111GSK3A0.43478638
112IRAK10.43456091
113MAPK40.43295731
114RPS6KL10.43285693
115RPS6KC10.43285693
116ICK0.40721021
117FGFR30.40419581
118STK40.39898781
119EPHA30.39705481
120MAP3K10.38950082
121PRKAA20.38557178
122PAK60.37582190
123DAPK30.37342827
124RPS6KA20.37143823
125NEK60.37025440
126STK30.35162522
127INSR0.34213513
128TYRO30.31987341
129PRKG20.31707965
130RET0.29429972
131PTK2B0.29344756
132MAP3K80.29320056
133IGF1R0.27494149
134MAP3K100.26950450
135PLK20.26003425
136SGK30.25824659
137MAPKAPK20.25348930
138PAK20.24165463

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005314.69325971
2Lysosome_Homo sapiens_hsa041424.49393078
3Other glycan degradation_Homo sapiens_hsa005112.93813791
4Leishmaniasis_Homo sapiens_hsa051402.81320020
5Staphylococcus aureus infection_Homo sapiens_hsa051502.61349729
6Osteoclast differentiation_Homo sapiens_hsa043802.54621021
7Phagosome_Homo sapiens_hsa041452.46430341
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.35798088
9Tuberculosis_Homo sapiens_hsa051522.33884459
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.23959327
11Rheumatoid arthritis_Homo sapiens_hsa053232.23259655
12Collecting duct acid secretion_Homo sapiens_hsa049662.21060602
13Malaria_Homo sapiens_hsa051441.97300054
14Pertussis_Homo sapiens_hsa051331.85371279
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.75867617
16B cell receptor signaling pathway_Homo sapiens_hsa046621.74701177
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.73199108
18Autoimmune thyroid disease_Homo sapiens_hsa053201.65678957
19Antigen processing and presentation_Homo sapiens_hsa046121.61271254
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.56423781
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.49863950
22Apoptosis_Homo sapiens_hsa042101.47764624
23Legionellosis_Homo sapiens_hsa051341.45822949
24Salmonella infection_Homo sapiens_hsa051321.41772509
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.35041615
26Caffeine metabolism_Homo sapiens_hsa002321.34790535
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34534584
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.33603562
29Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.31203612
30Measles_Homo sapiens_hsa051621.29687675
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28329912
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27081680
33Type I diabetes mellitus_Homo sapiens_hsa049401.26006170
34Toxoplasmosis_Homo sapiens_hsa051451.25809613
35Shigellosis_Homo sapiens_hsa051311.24500756
36Sphingolipid metabolism_Homo sapiens_hsa006001.24287308
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21536553
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19754109
39Influenza A_Homo sapiens_hsa051641.16738042
40TNF signaling pathway_Homo sapiens_hsa046681.13697358
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08438103
42Vibrio cholerae infection_Homo sapiens_hsa051101.08396677
43Chronic myeloid leukemia_Homo sapiens_hsa052200.98914626
44Amoebiasis_Homo sapiens_hsa051460.96414184
45Asthma_Homo sapiens_hsa053100.95978330
46Hematopoietic cell lineage_Homo sapiens_hsa046400.90720332
47Hepatitis B_Homo sapiens_hsa051610.90560959
48PPAR signaling pathway_Homo sapiens_hsa033200.90107005
49Steroid biosynthesis_Homo sapiens_hsa001000.89933878
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.89636318
51Chemokine signaling pathway_Homo sapiens_hsa040620.89352604
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83715006
53Hepatitis C_Homo sapiens_hsa051600.83563529
54Sphingolipid signaling pathway_Homo sapiens_hsa040710.82170594
55Pancreatic cancer_Homo sapiens_hsa052120.81097977
56Graft-versus-host disease_Homo sapiens_hsa053320.80501031
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.79055500
58Synaptic vesicle cycle_Homo sapiens_hsa047210.78927294
59Type II diabetes mellitus_Homo sapiens_hsa049300.78054300
60Renin-angiotensin system_Homo sapiens_hsa046140.77798199
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77730715
62Complement and coagulation cascades_Homo sapiens_hsa046100.76111014
63Endocytosis_Homo sapiens_hsa041440.75386564
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74628708
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74170080
66Acute myeloid leukemia_Homo sapiens_hsa052210.73692314
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.72330104
68HIF-1 signaling pathway_Homo sapiens_hsa040660.70588125
69Bladder cancer_Homo sapiens_hsa052190.69616753
70Allograft rejection_Homo sapiens_hsa053300.69526174
71Galactose metabolism_Homo sapiens_hsa000520.68278286
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.66836453
73Mineral absorption_Homo sapiens_hsa049780.66485260
74Viral myocarditis_Homo sapiens_hsa054160.65897687
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64862657
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64606938
77Platelet activation_Homo sapiens_hsa046110.64391669
78Renal cell carcinoma_Homo sapiens_hsa052110.62537540
79Proteoglycans in cancer_Homo sapiens_hsa052050.62059224
80VEGF signaling pathway_Homo sapiens_hsa043700.61718070
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60586474
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60004071
83T cell receptor signaling pathway_Homo sapiens_hsa046600.58377739
84Herpes simplex infection_Homo sapiens_hsa051680.53687123
85mTOR signaling pathway_Homo sapiens_hsa041500.53537336
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52045386
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51626898
88Glioma_Homo sapiens_hsa052140.51396601
89African trypanosomiasis_Homo sapiens_hsa051430.50142151
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.47809569
91Prolactin signaling pathway_Homo sapiens_hsa049170.45671858
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45497411
93Fructose and mannose metabolism_Homo sapiens_hsa000510.43577084
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.43315241
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42959591
96Sulfur metabolism_Homo sapiens_hsa009200.41701067
97Non-small cell lung cancer_Homo sapiens_hsa052230.41674357
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39739331
99Small cell lung cancer_Homo sapiens_hsa052220.39541218
100Viral carcinogenesis_Homo sapiens_hsa052030.35778558
101Insulin resistance_Homo sapiens_hsa049310.34831125
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.34464608
103Ether lipid metabolism_Homo sapiens_hsa005650.33155998
104Focal adhesion_Homo sapiens_hsa045100.31773505
105Dorso-ventral axis formation_Homo sapiens_hsa043200.31091988
106Colorectal cancer_Homo sapiens_hsa052100.29734247
107Pentose phosphate pathway_Homo sapiens_hsa000300.29603476
108ECM-receptor interaction_Homo sapiens_hsa045120.27458168
109Prion diseases_Homo sapiens_hsa050200.27079252
110MicroRNAs in cancer_Homo sapiens_hsa052060.26830636
111Epstein-Barr virus infection_Homo sapiens_hsa051690.26523227
112Starch and sucrose metabolism_Homo sapiens_hsa005000.25787047
113GnRH signaling pathway_Homo sapiens_hsa049120.25341923
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24522356
115Notch signaling pathway_Homo sapiens_hsa043300.23686961
116Glutathione metabolism_Homo sapiens_hsa004800.19751624

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