GPR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)9.75092978
2piRNA metabolic process (GO:0034587)9.61813976
3female gamete generation (GO:0007292)6.26436409
4DNA methylation involved in gamete generation (GO:0043046)6.24607395
5mitotic metaphase plate congression (GO:0007080)5.91453567
6regulation of meiosis (GO:0040020)5.86436876
7negative regulation of meiosis (GO:0045835)5.76011429
8attachment of spindle microtubules to kinetochore (GO:0008608)5.65541931
9regulation of acrosome reaction (GO:0060046)5.64307937
10negative regulation of smooth muscle cell differentiation (GO:0051151)5.37850510
11meiotic cell cycle (GO:0051321)5.36694601
12histone H2A monoubiquitination (GO:0035518)5.30631562
13notochord development (GO:0030903)5.21254777
14male meiosis (GO:0007140)5.20290419
15base-excision repair, AP site formation (GO:0006285)5.14230875
16regulation of exit from mitosis (GO:0007096)5.12208977
17multicellular organism reproduction (GO:0032504)4.97037431
18histone H2A ubiquitination (GO:0033522)4.95701045
19oocyte maturation (GO:0001556)4.94785954
20pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.90360164
21negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.89993324
22mitotic chromosome condensation (GO:0007076)4.89450147
23metaphase plate congression (GO:0051310)4.73558518
24endothelium development (GO:0003158)4.62912651
25regulation of meiotic cell cycle (GO:0051445)4.58231325
26sphingosine metabolic process (GO:0006670)4.56286598
27regulation of meiosis I (GO:0060631)4.52715960
28protein K6-linked ubiquitination (GO:0085020)4.48129730
29platelet dense granule organization (GO:0060155)4.47163974
30sphingoid metabolic process (GO:0046519)4.46210694
31establishment of chromosome localization (GO:0051303)4.45372161
32diol metabolic process (GO:0034311)4.42322996
33meiotic chromosome segregation (GO:0045132)4.39274709
34sequestering of extracellular ligand from receptor (GO:0035581)4.33360158
35regulation of RIG-I signaling pathway (GO:0039535)4.27414991
36female gonad development (GO:0008585)4.21908388
37regulation of hypersensitivity (GO:0002883)4.19356664
38maturation of 5.8S rRNA (GO:0000460)4.17905391
39DNA damage induced protein phosphorylation (GO:0006975)4.14534122
40negative regulation of meiotic cell cycle (GO:0051447)4.12592560
41protein localization to kinetochore (GO:0034501)4.07761015
42lipopolysaccharide biosynthetic process (GO:0009103)4.07138460
43negative regulation of reproductive process (GO:2000242)4.06890013
44oocyte development (GO:0048599)4.01134517
45type B pancreatic cell proliferation (GO:0044342)4.00791060
46regulation of retinoic acid receptor signaling pathway (GO:0048385)3.99830295
47lymphangiogenesis (GO:0001946)3.95033209
48pyrimidine nucleotide catabolic process (GO:0006244)3.94401085
49citrulline biosynthetic process (GO:0019240)3.90753325
50regulation of integrin-mediated signaling pathway (GO:2001044)3.90457249
51regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.88304069
52DNA methylation (GO:0006306)3.87563138
53DNA alkylation (GO:0006305)3.87563138
54mitotic sister chromatid segregation (GO:0000070)3.86807350
55behavioral response to nicotine (GO:0035095)3.83783984
56chondrocyte proliferation (GO:0035988)3.76811219
57glycerophospholipid catabolic process (GO:0046475)3.76274790
58negative regulation of nitric-oxide synthase activity (GO:0051001)3.74179278
59regulation of DNA methylation (GO:0044030)3.69867692
60regulation of transforming growth factor beta2 production (GO:0032909)3.68545651
61regulation of sister chromatid cohesion (GO:0007063)3.67882777
62negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.67671032
63negative regulation of DNA-templated transcription, elongation (GO:0032785)3.67671032
64oogenesis (GO:0048477)3.67335471
65gene silencing by RNA (GO:0031047)3.64816071
66reproduction (GO:0000003)3.64399631
67response to gravity (GO:0009629)3.61337446
68CENP-A containing nucleosome assembly (GO:0034080)3.61289426
69regulation of phospholipid biosynthetic process (GO:0071071)3.60501340
70microtubule severing (GO:0051013)3.58214729
71positive regulation of DNA-dependent DNA replication (GO:2000105)3.54013663
72protein localization to chromosome, centromeric region (GO:0071459)3.53765539
73regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.52283836
74collagen fibril organization (GO:0030199)3.47739578
75protein deneddylation (GO:0000338)3.47095794
76chromosome segregation (GO:0007059)3.44403822
77chromatin remodeling at centromere (GO:0031055)3.43604656
78positive regulation of meiosis (GO:0045836)3.39904883
79kinetochore assembly (GO:0051382)3.38307779
80negative regulation of homotypic cell-cell adhesion (GO:0034111)3.34385669
81positive regulation of humoral immune response (GO:0002922)3.34293432
82epithelial cilium movement (GO:0003351)3.32086734
83protein localization to chromosome (GO:0034502)3.31970681
84positive regulation of megakaryocyte differentiation (GO:0045654)3.31280145
85protein heterotrimerization (GO:0070208)3.30719955
86negative regulation of hormone metabolic process (GO:0032351)3.28056751
87negative regulation of hormone biosynthetic process (GO:0032353)3.28056751
88regulation of histone H3-K27 methylation (GO:0061085)3.27386675
89pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.26857652
90negative regulation of cell division (GO:0051782)3.26568527
91spindle checkpoint (GO:0031577)3.24315211
92negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.23771810
93protein kinase C signaling (GO:0070528)3.22935271
94fertilization (GO:0009566)3.22384515
95positive regulation of Cdc42 GTPase activity (GO:0043089)3.22039740
96ovulation cycle (GO:0042698)3.21463959
97dermatan sulfate biosynthetic process (GO:0030208)3.17897469
98phosphatidylglycerol biosynthetic process (GO:0006655)3.17613761
99negative regulation of nuclear division (GO:0051784)3.17173396
100positive regulation of meiotic cell cycle (GO:0051446)3.16922484
101mesenchymal-epithelial cell signaling (GO:0060638)3.16382971
102negative regulation of axon guidance (GO:1902668)3.15551041
103N-terminal protein amino acid acetylation (GO:0006474)3.12800012
104protein-chromophore linkage (GO:0018298)3.12596416
105lipopolysaccharide metabolic process (GO:0008653)3.11266050
106negative regulation of axon extension involved in axon guidance (GO:0048843)3.10110528
107protein neddylation (GO:0045116)3.09278798
108DNA replication-independent nucleosome organization (GO:0034724)3.08458294
109DNA replication-independent nucleosome assembly (GO:0006336)3.08458294
110immunoglobulin mediated immune response (GO:0016064)3.07357403
111ovarian follicle development (GO:0001541)3.06751466
112kinetochore organization (GO:0051383)3.06392935
113histone exchange (GO:0043486)3.06001668
114rhodopsin mediated signaling pathway (GO:0016056)3.03565909
115positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.02688716
116rRNA methylation (GO:0031167)3.01049712
117parturition (GO:0007567)3.00290805
118histone monoubiquitination (GO:0010390)2.98869330
119regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.97573689
120cartilage morphogenesis (GO:0060536)2.97385888
121regulation of spindle organization (GO:0090224)2.96187111
122DNA modification (GO:0006304)2.95903704
123type B pancreatic cell development (GO:0003323)2.93604385
124DNA methylation or demethylation (GO:0044728)2.93393595
125negative regulation of BMP signaling pathway (GO:0030514)2.92940562
126regulation of rhodopsin mediated signaling pathway (GO:0022400)2.92342065
127negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91632005
128retinal cone cell development (GO:0046549)2.88641246
129water-soluble vitamin biosynthetic process (GO:0042364)2.88614369
130negative regulation of nitric oxide biosynthetic process (GO:0045019)2.88023585
131smooth muscle tissue development (GO:0048745)2.81761398
132extracellular regulation of signal transduction (GO:1900115)2.76147805
133extracellular negative regulation of signal transduction (GO:1900116)2.76147805
134response to redox state (GO:0051775)2.75403719
135tachykinin receptor signaling pathway (GO:0007217)2.73483102
136regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.71859882
137regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.69566195
138cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.67268922
139dermatan sulfate metabolic process (GO:0030205)2.67263918
140activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.65038345
141cullin deneddylation (GO:0010388)2.64217084
142regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.63744693
143negative regulation of protein localization to cell surface (GO:2000009)2.62669426
144cilium movement (GO:0003341)2.61194918
145regulation of gonadotropin secretion (GO:0032276)2.59803110
146negative regulation of stem cell proliferation (GO:2000647)2.59484195
147cilium morphogenesis (GO:0060271)2.57848258
148behavioral response to ethanol (GO:0048149)2.57382989
149substrate adhesion-dependent cell spreading (GO:0034446)2.55333775
150positive regulation of cartilage development (GO:0061036)2.53298502
151epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.53276987
152negative regulation of mast cell activation (GO:0033004)2.52570563
153positive regulation of protein autophosphorylation (GO:0031954)2.50571700
154negative regulation of telomere maintenance (GO:0032205)2.47612827
155serotonin receptor signaling pathway (GO:0007210)2.44078347
156negative chemotaxis (GO:0050919)2.42616703
157fucose catabolic process (GO:0019317)2.42542240
158L-fucose metabolic process (GO:0042354)2.42542240
159L-fucose catabolic process (GO:0042355)2.42542240
160postsynaptic membrane organization (GO:0001941)2.40011937
161axoneme assembly (GO:0035082)2.38876116
162response to pheromone (GO:0019236)2.38130666
163sulfation (GO:0051923)2.36895667
164extracellular fibril organization (GO:0043206)2.36750059
165regulation of organ formation (GO:0003156)2.36276896
166preassembly of GPI anchor in ER membrane (GO:0016254)2.34406252
167intraciliary transport (GO:0042073)2.34178765
168extracellular matrix assembly (GO:0085029)2.33660158
169positive regulation of actin filament depolymerization (GO:0030836)2.33064437
170negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.32255332
171coenzyme catabolic process (GO:0009109)2.30768108
172detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.29892203
173sequestering of actin monomers (GO:0042989)2.27666359
174regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.25693829
175positive regulation of cardiac muscle cell differentiation (GO:2000727)2.25605735
176retina vasculature morphogenesis in camera-type eye (GO:0061299)2.25434059
177protein heterotetramerization (GO:0051290)2.25173947
178blood vessel maturation (GO:0001955)2.24880653
179organ induction (GO:0001759)2.24695361
180detection of light stimulus involved in sensory perception (GO:0050962)2.24382847
181detection of light stimulus involved in visual perception (GO:0050908)2.24382847
182glomerular basement membrane development (GO:0032836)2.24212094
183endodermal cell differentiation (GO:0035987)2.23948128
184regulation of BMP signaling pathway (GO:0030510)2.23191605
185regulation of neurotransmitter uptake (GO:0051580)2.22231820
186heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.21247269
187mannosylation (GO:0097502)2.20361218
188pericardium development (GO:0060039)2.19262230
189calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.18255981
190toxin metabolic process (GO:0009404)2.17208219
191embryonic cranial skeleton morphogenesis (GO:0048701)2.17059062
192sulfate transport (GO:0008272)2.16968577

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.26381711
2SMAD_19615063_ChIP-ChIP_OVARY_Human4.14153547
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.50958845
4* KAP1_22055183_ChIP-Seq_ESCs_Mouse3.48327744
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.31908161
6NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.24527683
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.21932293
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.07448278
9* SALL1_21062744_ChIP-ChIP_HESCs_Human2.97086903
10ZNF274_21170338_ChIP-Seq_K562_Hela2.83170210
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.53894742
12AR_21909140_ChIP-Seq_LNCAP_Human2.43355686
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.33313206
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.20461136
15P300_19829295_ChIP-Seq_ESCs_Human2.03881302
16* FLI1_27457419_Chip-Seq_LIVER_Mouse1.98667226
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92695437
18TP53_16413492_ChIP-PET_HCT116_Human1.85685653
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82703907
20PIAS1_25552417_ChIP-Seq_VCAP_Human1.80427531
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.77193236
22MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.75625834
23BRD4_25478319_ChIP-Seq_HGPS_Human1.75483202
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73790924
25CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.71659440
26GATA1_26923725_Chip-Seq_HPCs_Mouse1.71243137
27TP53_18474530_ChIP-ChIP_U2OS_Human1.70342170
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.70172684
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69746630
30* RNF2_27304074_Chip-Seq_NSC_Mouse1.68660269
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68172684
32* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66991901
33* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66590358
34* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.66538633
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66407573
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.65283276
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61611350
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61133913
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.59752949
40CDX2_22108803_ChIP-Seq_LS180_Human1.58941421
41CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57237587
42STAT1_17558387_ChIP-Seq_HELA_Human1.57009241
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56669706
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56212921
45RUNX1_26923725_Chip-Seq_HPCs_Mouse1.53742225
46MYC_18940864_ChIP-ChIP_HL60_Human1.53052055
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52284924
48ER_23166858_ChIP-Seq_MCF-7_Human1.51496614
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51305403
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50163781
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.49561746
52NRF2_20460467_ChIP-Seq_MEFs_Mouse1.49561746
53TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.46841543
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.45426907
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39716510
56FUS_26573619_Chip-Seq_HEK293_Human1.39625157
57* EZH2_27294783_Chip-Seq_NPCs_Mouse1.39545805
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39029707
59KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38915266
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38491009
61* STAT3_18555785_Chip-Seq_ESCs_Mouse1.38288461
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37976372
63* NANOG_18555785_Chip-Seq_ESCs_Mouse1.37955560
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37862611
65AR_25329375_ChIP-Seq_VCAP_Human1.37132170
66NANOG_19829295_ChIP-Seq_ESCs_Human1.36797889
67SOX2_19829295_ChIP-Seq_ESCs_Human1.36797889
68RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.36650007
69* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34108822
70* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33589265
71* NFE2_27457419_Chip-Seq_LIVER_Mouse1.32916032
72CBP_20019798_ChIP-Seq_JUKART_Human1.32077665
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32077665
74* STAT3_23295773_ChIP-Seq_U87_Human1.31261968
75AR_21572438_ChIP-Seq_LNCaP_Human1.29841138
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29545528
77NFYA_21822215_ChIP-Seq_K562_Human1.28815793
78* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.28340711
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27553529
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27426628
81TCF4_22108803_ChIP-Seq_LS180_Human1.27322817
82SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.26877853
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.26239750
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.25668949
85TP63_19390658_ChIP-ChIP_HaCaT_Human1.24818750
86TAF15_26573619_Chip-Seq_HEK293_Human1.24547459
87VDR_22108803_ChIP-Seq_LS180_Human1.23715093
88JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22822348
89* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22600771
90GBX2_23144817_ChIP-Seq_PC3_Human1.22289316
91* CRX_20693478_ChIP-Seq_RETINA_Mouse1.21922507
92BCAT_22108803_ChIP-Seq_LS180_Human1.21902714
93FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21843599
94GATA3_21867929_ChIP-Seq_TH1_Mouse1.20560069
95* KLF4_18555785_Chip-Seq_ESCs_Mouse1.20058223
96STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19785595
97LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19732526
98* CTCF_18555785_Chip-Seq_ESCs_Mouse1.19538476
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18868143
100KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.17844902
101SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17635191
102* E2F1_18555785_Chip-Seq_ESCs_Mouse1.16091786
103* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15858324
104* NMYC_18555785_Chip-Seq_ESCs_Mouse1.15499260
105ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14745300
106JUN_21703547_ChIP-Seq_K562_Human1.14590262
107TCF4_23295773_ChIP-Seq_U87_Human1.14454843
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14378269
109CBX2_27304074_Chip-Seq_ESCs_Mouse1.13469103
110CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12324764
111RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11411314
112FLI1_21867929_ChIP-Seq_TH2_Mouse1.11333761
113* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11288350
114EWS_26573619_Chip-Seq_HEK293_Human1.10963024
115* ZFX_18555785_Chip-Seq_ESCs_Mouse1.10813755
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10694273
117E2F1_21310950_ChIP-Seq_MCF-7_Human1.10269264
118* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10187125
119* SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.09085464
120HNFA_21074721_ChIP-Seq_CACO-2_Human1.08975352
121ELK1_19687146_ChIP-ChIP_HELA_Human1.08327705
122* SOX2_18555785_Chip-Seq_ESCs_Mouse1.07824617
123* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.07634185
124RUNX2_22187159_ChIP-Seq_PCA_Human1.07585468
125* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07568106
126SMAD4_21741376_ChIP-Seq_EPCs_Human1.07554138
127ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07362302
128GF1B_26923725_Chip-Seq_HPCs_Mouse1.06471943
129* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.06405063
130IGF1R_20145208_ChIP-Seq_DFB_Human1.05401100
131* CJUN_26792858_Chip-Seq_BT549_Human1.05019611
132SMAD3_21741376_ChIP-Seq_EPCs_Human1.04968571
133* OCT4_18555785_Chip-Seq_ESCs_Mouse1.04349849
134SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.03881979
135* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03498372
136* CMYC_18555785_Chip-Seq_ESCs_Mouse1.02862025
137AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02685922
138DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01213210
139MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01092785
140* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01047710
141KDM2B_26808549_Chip-Seq_REH_Human1.00947850
142ELK4_26923725_Chip-Seq_MESODERM_Mouse1.00585351
143EZH2_22144423_ChIP-Seq_EOC_Human1.00291060
144* KAP1_27257070_Chip-Seq_ESCs_Mouse0.99578252
145* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99539828
146* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99483532
147HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99083789
148PHF8_20622853_ChIP-Seq_HELA_Human0.97460573
149* P53_22387025_ChIP-Seq_ESCs_Mouse0.97328816
150* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97222835
151PRDM14_20953172_ChIP-Seq_ESCs_Human0.96924524
152TP53_22573176_ChIP-Seq_HFKS_Human0.96617335
153RBPJ_21746931_ChIP-Seq_IB4_Human0.96513609
154ETV1_20927104_ChIP-Seq_GIST48_Human0.96408760
155EP300_21415370_ChIP-Seq_HL-1_Mouse0.96197216
156SMAD4_21799915_ChIP-Seq_A2780_Human0.96193355
157PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95169141
158GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95057748
159* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.94397504
160TBL1_22424771_ChIP-Seq_293T_Human0.93816296

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect6.86170624
2MP0008438_abnormal_cutaneous_collagen5.47453076
3MP0003646_muscle_fatigue4.63818202
4MP0008877_abnormal_DNA_methylation4.13177758
5MP0003787_abnormal_imprinting3.90453471
6MP0005451_abnormal_body_composition3.81178644
7MP0005171_absent_coat_pigmentation3.74269948
8MP0003693_abnormal_embryo_hatching3.67032875
9MP0005503_abnormal_tendon_morphology3.38771532
10MP0005275_abnormal_skin_tensile3.19586480
11MP0010094_abnormal_chromosome_stability3.07467883
12MP0001119_abnormal_female_reproductive2.99658140
13MP0005395_other_phenotype2.98690925
14MP0003121_genomic_imprinting2.96338994
15MP0002102_abnormal_ear_morphology2.88318766
16MP0001958_emphysema2.86048693
17MP0003123_paternal_imprinting2.84250823
18MP0003279_aneurysm2.81769927
19MP0003699_abnormal_female_reproductive2.75893551
20MP0006292_abnormal_olfactory_placode2.75566921
21MP0009384_cardiac_valve_regurgitation2.59627031
22MP0000569_abnormal_digit_pigmentation2.53157370
23MP0010368_abnormal_lymphatic_system2.48020245
24MP0003136_yellow_coat_color2.36939102
25MP0001542_abnormal_bone_strength2.35342993
26MP0003111_abnormal_nucleus_morphology2.35173316
27MP0006054_spinal_hemorrhage2.31501948
28MP0003077_abnormal_cell_cycle2.28484481
29MP0005646_abnormal_pituitary_gland2.18238880
30MP0001929_abnormal_gametogenesis2.17111336
31MP0005408_hypopigmentation2.14178501
32MP0004272_abnormal_basement_membrane2.08155463
33MP0000653_abnormal_sex_gland2.06011838
34MP0004957_abnormal_blastocyst_morpholog2.03855400
35MP0010386_abnormal_urinary_bladder2.03417788
36MP0005623_abnormal_meninges_morphology1.92504897
37MP0002295_abnormal_pulmonary_circulatio1.92006612
38MP0002210_abnormal_sex_determination1.90132152
39MP0002938_white_spotting1.89569139
40MP0003705_abnormal_hypodermis_morpholog1.89068415
41MP0003011_delayed_dark_adaptation1.88618857
42MP0002653_abnormal_ependyma_morphology1.79350626
43MP0000579_abnormal_nail_morphology1.78526407
44MP0009250_abnormal_appendicular_skeleto1.73994868
45MP0003315_abnormal_perineum_morphology1.69039539
46MP0008932_abnormal_embryonic_tissue1.68863924
47MP0003724_increased_susceptibility_to1.64460164
48MP0002234_abnormal_pharynx_morphology1.60710349
49MP0009780_abnormal_chondrocyte_physiolo1.57963206
50MP0008775_abnormal_heart_ventricle1.56983428
51MP0002249_abnormal_larynx_morphology1.53961000
52MP0000749_muscle_degeneration1.53740279
53MP0003937_abnormal_limbs/digits/tail_de1.46379073
54MP0004264_abnormal_extraembryonic_tissu1.41259218
55MP0002161_abnormal_fertility/fecundity1.39652874
56MP0003045_fibrosis1.39390527
57MP0005551_abnormal_eye_electrophysiolog1.38419623
58MP0001905_abnormal_dopamine_level1.37993140
59MP0008004_abnormal_stomach_pH1.37818715
60MP0009697_abnormal_copulation1.37257092
61MP0001299_abnormal_eye_distance/1.35519061
62MP0003195_calcinosis1.35172075
63MP0008058_abnormal_DNA_repair1.33616112
64MP0005084_abnormal_gallbladder_morpholo1.30402057
65MP0005670_abnormal_white_adipose1.29677745
66MP0004885_abnormal_endolymph1.29388114
67MP0002877_abnormal_melanocyte_morpholog1.27928991
68MP0003283_abnormal_digestive_organ1.24672759
69MP0002168_other_aberrant_phenotype1.24079618
70MP0001145_abnormal_male_reproductive1.22935943
71MP0000534_abnormal_ureter_morphology1.22387717
72MP0003950_abnormal_plasma_membrane1.21336548
73MP0008007_abnormal_cellular_replicative1.20880620
74MP0001919_abnormal_reproductive_system1.20343370
75MP0005595_abnormal_vascular_smooth1.18369762
76MP0008789_abnormal_olfactory_epithelium1.17058902
77MP0005253_abnormal_eye_physiology1.16254150
78MP0008875_abnormal_xenobiotic_pharmacok1.12993098
79MP0000538_abnormal_urinary_bladder1.09119348
80MP0005410_abnormal_fertilization1.08186629
81MP0005389_reproductive_system_phenotype1.07393694
82MP0005167_abnormal_blood-brain_barrier1.06030395
83MP0005187_abnormal_penis_morphology1.05259870
84MP0004145_abnormal_muscle_electrophysio1.03810128
85MP0004142_abnormal_muscle_tone1.03779907
86MP0004084_abnormal_cardiac_muscle1.00809534
87MP0003941_abnormal_skin_development0.99293879
88MP0001984_abnormal_olfaction0.98682353
89MP0000230_abnormal_systemic_arterial0.98459079
90MP0001915_intracranial_hemorrhage0.98367852
91MP0002060_abnormal_skin_morphology0.98184616
92MP0003252_abnormal_bile_duct0.98167930
93MP0002928_abnormal_bile_duct0.97491617
94MP0000613_abnormal_salivary_gland0.97153054
95MP0001851_eye_inflammation0.96383712
96MP0005257_abnormal_intraocular_pressure0.95624708
97MP0000639_abnormal_adrenal_gland0.95316442
98MP0003755_abnormal_palate_morphology0.95257885
99MP0004133_heterotaxia0.94750072
100MP0005023_abnormal_wound_healing0.94393712
101MP0009053_abnormal_anal_canal0.93997028
102MP0000350_abnormal_cell_proliferation0.93862085
103MP0002751_abnormal_autonomic_nervous0.93719895
104MP0002085_abnormal_embryonic_tissue0.93124357
105MP0004782_abnormal_surfactant_physiolog0.90565834
106MP0000372_irregular_coat_pigmentation0.89206725
107MP0005380_embryogenesis_phenotype0.88048974
108MP0001672_abnormal_embryogenesis/_devel0.88048974
109MP0002736_abnormal_nociception_after0.87778963
110MP0002282_abnormal_trachea_morphology0.86544464
111MP0001529_abnormal_vocalization0.86170137
112MP0000678_abnormal_parathyroid_gland0.85859574
113MP0000013_abnormal_adipose_tissue0.83389893
114MP0005085_abnormal_gallbladder_physiolo0.82673025
115MP0000343_altered_response_to0.82468359
116MP0001968_abnormal_touch/_nociception0.80922076
117MP0000049_abnormal_middle_ear0.80231515
118MP0005379_endocrine/exocrine_gland_phen0.79813383
119MP0001730_embryonic_growth_arrest0.77988633
120MP0002127_abnormal_cardiovascular_syste0.77631283
121MP0002638_abnormal_pupillary_reflex0.77420760
122MP0008872_abnormal_physiological_respon0.76538288
123MP0005360_urolithiasis0.75124982
124MP0001697_abnormal_embryo_size0.73608744
125MP0003879_abnormal_hair_cell0.73406444
126MP0002108_abnormal_muscle_morphology0.73305188
127MP0005620_abnormal_muscle_contractility0.72721124
128MP0001661_extended_life_span0.72684746
129MP0002272_abnormal_nervous_system0.72219110
130MP0002163_abnormal_gland_morphology0.71779658
131MP0003890_abnormal_embryonic-extraembry0.71012263
132MP0006072_abnormal_retinal_apoptosis0.70932125
133MP0002084_abnormal_developmental_patter0.69164629
134MP0002837_dystrophic_cardiac_calcinosis0.69038116
135MP0000465_gastrointestinal_hemorrhage0.67900475
136MP0002177_abnormal_outer_ear0.67787640
137MP0001243_abnormal_dermal_layer0.66692728
138MP0002933_joint_inflammation0.66319595
139MP0005195_abnormal_posterior_eye0.65926355
140MP0002019_abnormal_tumor_incidence0.65491045
141MP0005197_abnormal_uvea_morphology0.64710113
142MP0002115_abnormal_skeleton_extremities0.63215474
143MP0003942_abnormal_urinary_system0.62997670
144MP0009745_abnormal_behavioral_response0.62651167
145MP0003786_premature_aging0.61914308
146MP0000026_abnormal_inner_ear0.61693810
147MP0003091_abnormal_cell_migration0.61674246
148MP0002109_abnormal_limb_morphology0.61493902
149MP0005621_abnormal_cell_physiology0.60424777
150MP0002116_abnormal_craniofacial_bone0.59058538
151MP0000462_abnormal_digestive_system0.58834517
152MP0002752_abnormal_somatic_nervous0.57654655
153MP0000163_abnormal_cartilage_morphology0.57419340
154MP0003186_abnormal_redox_activity0.56514199
155MP0001879_abnormal_lymphatic_vessel0.56287637
156MP0000427_abnormal_hair_cycle0.55470145
157MP0002932_abnormal_joint_morphology0.53520302
158MP0000767_abnormal_smooth_muscle0.53483717
159MP0004484_altered_response_of0.52297932
160MP0002113_abnormal_skeleton_development0.51564454
161MP0002160_abnormal_reproductive_system0.50776625
162MP0004510_myositis0.49980530
163MP0003984_embryonic_growth_retardation0.49747546
164MP0003453_abnormal_keratinocyte_physiol0.49689674
165MP0002086_abnormal_extraembryonic_tissu0.49673708
166MP0005508_abnormal_skeleton_morphology0.49154032
167MP0002332_abnormal_exercise_endurance0.48824697
168MP0010030_abnormal_orbit_morphology0.48782656
169MP0006276_abnormal_autonomic_nervous0.48446813
170MP0005384_cellular_phenotype0.48398479

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)7.31656232
2Cortical dysplasia (HP:0002539)5.39428959
3Flat capital femoral epiphysis (HP:0003370)5.37154357
4Chromsome breakage (HP:0040012)5.14072489
5Chromosomal breakage induced by crosslinking agents (HP:0003221)5.06810302
6Irregular epiphyses (HP:0010582)4.77847775
7Premature ovarian failure (HP:0008209)4.71170795
8Premature rupture of membranes (HP:0001788)4.51124140
9Abnormality of the labia minora (HP:0012880)4.49339255
10Adrenal hypoplasia (HP:0000835)4.46415932
11Birth length less than 3rd percentile (HP:0003561)4.32776024
12Infertility (HP:0000789)4.00779480
13Breast hypoplasia (HP:0003187)3.93223271
14Papillary thyroid carcinoma (HP:0002895)3.85013425
15Protrusio acetabuli (HP:0003179)3.84118536
16Pancreatic cysts (HP:0001737)3.83714540
17Pancreatic fibrosis (HP:0100732)3.74053357
18Patellar aplasia (HP:0006443)3.73584010
19Mesomelia (HP:0003027)3.49243901
20Insulin-resistant diabetes mellitus (HP:0000831)3.46289841
21Molar tooth sign on MRI (HP:0002419)3.40457586
22Abnormality of midbrain morphology (HP:0002418)3.40457586
23Shawl scrotum (HP:0000049)3.38241731
24True hermaphroditism (HP:0010459)3.36222594
25Aplasia/Hypoplasia of the patella (HP:0006498)3.35169384
26Increased corneal curvature (HP:0100692)3.33246651
27Keratoconus (HP:0000563)3.33246651
28Aortic dissection (HP:0002647)3.27786831
29Secondary amenorrhea (HP:0000869)3.21490092
30Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.16290600
31Abnormality of femoral epiphyses (HP:0006499)3.16290600
32Follicular hyperkeratosis (HP:0007502)3.15473983
33Hypergonadotropic hypogonadism (HP:0000815)3.15412965
34Nephronophthisis (HP:0000090)3.12416839
35Arterial tortuosity (HP:0005116)3.09840953
36Soft skin (HP:0000977)3.09593677
37Abnormality of the epiphysis of the femoral head (HP:0010574)3.08364398
38Aplasia/Hypoplasia of the tibia (HP:0005772)3.06116961
39Aplasia/Hypoplasia of the tongue (HP:0010295)3.05129420
40Vitreoretinal degeneration (HP:0000655)3.00673899
41Nephroblastoma (Wilms tumor) (HP:0002667)2.96617260
42Aortic aneurysm (HP:0004942)2.94380182
43Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.91532065
44Short tibia (HP:0005736)2.91299693
45Abnormality of the femoral head (HP:0003368)2.88493072
46Breast aplasia (HP:0100783)2.87310748
47Pulmonary fibrosis (HP:0002206)2.83991636
48Abnormality of chromosome segregation (HP:0002916)2.83738234
49Aplasia/Hypoplasia of the breasts (HP:0010311)2.82203545
50Congenital stationary night blindness (HP:0007642)2.78593050
51Ankle contracture (HP:0006466)2.75235854
52Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.74322056
53Absent epiphyses (HP:0010577)2.74322056
54Embryonal renal neoplasm (HP:0011794)2.73858831
55Abnormality of chromosome stability (HP:0003220)2.72751763
56Abnormality of the renal medulla (HP:0100957)2.71188130
57Abnormality of dentin (HP:0010299)2.70939293
58Vascular tortuosity (HP:0004948)2.69710808
59Aplasia/Hypoplasia of the uvula (HP:0010293)2.67279809
60Hypoplasia of the capital femoral epiphysis (HP:0003090)2.64670384
61Medial flaring of the eyebrow (HP:0010747)2.63890931
62Abnormality of the proximal phalanges of the hand (HP:0009834)2.62042917
63Muscle fiber atrophy (HP:0100295)2.61064330
64Facial hemangioma (HP:0000329)2.59908030
65Delayed gross motor development (HP:0002194)2.59274138
66Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.57831862
67Atelectasis (HP:0100750)2.56530269
68Chorioretinal atrophy (HP:0000533)2.56036451
69Hypoplasia of the fovea (HP:0007750)2.55789692
70Aplasia/Hypoplasia of the fovea (HP:0008060)2.55789692
71Tubular atrophy (HP:0000092)2.52535083
72Capillary hemangiomas (HP:0005306)2.52436137
73Abnormality of the renal cortex (HP:0011035)2.52031482
74Aplasia/Hypoplasia of the sternum (HP:0006714)2.47482245
75Abnormality of the fovea (HP:0000493)2.46154531
76Aortic valve stenosis (HP:0001650)2.43862102
77Epiphyseal dysplasia (HP:0002656)2.42889382
78Cardiovascular calcification (HP:0011915)2.37763350
79Broad ribs (HP:0000885)2.36055259
80Abnormality of the preputium (HP:0100587)2.36010206
81Meckel diverticulum (HP:0002245)2.28092236
82Cystic liver disease (HP:0006706)2.28005512
83Supernumerary spleens (HP:0009799)2.27128195
84Fibular aplasia (HP:0002990)2.24355391
85Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.23974529
86Ectopic kidney (HP:0000086)2.23735292
87Occipital encephalocele (HP:0002085)2.22797092
88Mitral stenosis (HP:0001718)2.21009087
89Small intestinal stenosis (HP:0012848)2.20952941
90Duodenal stenosis (HP:0100867)2.20952941
91Decreased muscle mass (HP:0003199)2.20082786
92Anencephaly (HP:0002323)2.19184467
93Absent radius (HP:0003974)2.18549773
94Long clavicles (HP:0000890)2.16908607
95Hyperglycemia (HP:0003074)2.16514612
96Abnormality of incisor morphology (HP:0011063)2.16251818
97Aortic regurgitation (HP:0001659)2.16117003
98Spondylolisthesis (HP:0003302)2.16033693
99Chronic hepatic failure (HP:0100626)2.14950891
100Nonprogressive disorder (HP:0003680)2.13360896
101Focal motor seizures (HP:0011153)2.13223221
102Small epiphyses (HP:0010585)2.12215807
103Sclerocornea (HP:0000647)2.11825815
104Absent hand (HP:0004050)2.11691956
105Sloping forehead (HP:0000340)2.10978708
106Redundant skin (HP:0001582)2.08939426
107Aplasia/Hypoplasia involving the musculature (HP:0001460)2.07854821
108Coronal craniosynostosis (HP:0004440)2.07367364
109Aplastic anemia (HP:0001915)2.07235067
110Type II lissencephaly (HP:0007260)2.07003306
111Type 2 muscle fiber atrophy (HP:0003554)2.06605792
112Primary amenorrhea (HP:0000786)2.06144355
113Wrist flexion contracture (HP:0001239)2.05814948
114Abnormality of the ileum (HP:0001549)2.05138363
115Aplasia involving forearm bones (HP:0009822)2.04758482
116Absent forearm bone (HP:0003953)2.04758482
117Striae distensae (HP:0001065)2.03476900
118Carpal bone hypoplasia (HP:0001498)2.03382258
119Genu varum (HP:0002970)2.02377525
120Sandal gap (HP:0001852)2.01991785
121Fetal akinesia sequence (HP:0001989)2.01670041
122Abnormality of the wing of the ilium (HP:0011867)2.01093312
123Bladder diverticulum (HP:0000015)2.00485468
124Abnormality of the middle phalanges of the toes (HP:0010183)2.00283693
125Short thumb (HP:0009778)1.99737815
126Abnormality of the phalanges of the hallux (HP:0010057)1.99012081
127Abnormal albumin level (HP:0012116)1.98304307
128Hypoalbuminemia (HP:0003073)1.98304307
129Gait imbalance (HP:0002141)1.97203419
130Cervical subluxation (HP:0003308)1.97159224
131Round ear (HP:0100830)1.97004646
132Congenital primary aphakia (HP:0007707)1.96501427
133Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.96422333
134Cystic hygroma (HP:0000476)1.95259264
135Rhabdomyosarcoma (HP:0002859)1.93806977
136Aplasia/Hypoplasia of the lens (HP:0008063)1.93513130
137Congenital, generalized hypertrichosis (HP:0004540)1.90823348
138Pendular nystagmus (HP:0012043)1.90725661
139Flared iliac wings (HP:0002869)1.89882758
140Absent phalangeal crease (HP:0006109)1.89710763
141Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.89126621
142Broad metatarsal (HP:0001783)1.88735760
143Acute myeloid leukemia (HP:0004808)1.88595637
144Thyroid carcinoma (HP:0002890)1.88298474
145Clubbing of toes (HP:0100760)1.86386101
146Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.85685171
147Genu recurvatum (HP:0002816)1.81011821
148Myelodysplasia (HP:0002863)1.79671319
149Hypoplastic iliac wings (HP:0002866)1.79593232
150Delayed puberty (HP:0000823)1.79498124
151Abnormality of the carotid arteries (HP:0005344)1.78993149
152Hypogonadotrophic hypogonadism (HP:0000044)1.78762825
153Abnormality of the intervertebral disk (HP:0005108)1.78469638
154Hypoplastic ischia (HP:0003175)1.78312304
155Fatigable weakness (HP:0003473)1.77766747
156Abnormality of the neuromuscular junction (HP:0003398)1.77766747
157Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.77552153
158Amniotic constriction ring (HP:0009775)1.76369791
159Abnormality of placental membranes (HP:0011409)1.76369791
160Abnormality of the duodenum (HP:0002246)1.75073364
161Aplasia of the musculature (HP:0100854)1.75030389
162Hypoventilation (HP:0002791)1.74860480
163Prostate neoplasm (HP:0100787)1.74797020
164Ovoid vertebral bodies (HP:0003300)1.74779767
165Pulmonary artery stenosis (HP:0004415)1.74711836
166Chronic bronchitis (HP:0004469)1.74265855
167Entropion (HP:0000621)1.73802697
168Cupped ribs (HP:0000887)1.73576502
169Abnormality of the distal phalanx of the thumb (HP:0009617)1.73078104
170Postaxial hand polydactyly (HP:0001162)1.72619554
171Abnormal respiratory motile cilium physiology (HP:0012261)1.72447180
172Congenital hepatic fibrosis (HP:0002612)1.72418211
173Disproportionate short-trunk short stature (HP:0003521)1.71669222
174Congenital sensorineural hearing impairment (HP:0008527)1.71553982
175Exertional dyspnea (HP:0002875)1.71373223
176Nephrogenic diabetes insipidus (HP:0009806)1.71129899
177Short foot (HP:0001773)1.70964517
178Abnormal ciliary motility (HP:0012262)1.70735124
179Postaxial foot polydactyly (HP:0001830)1.69806252
180Thin ribs (HP:0000883)1.69402810
181Atrophic scars (HP:0001075)1.67789416
182Amelogenesis imperfecta (HP:0000705)1.67514842
183Abnormality of the phalanges of the 5th finger (HP:0004213)1.65430288
184Abnormality of the anterior chamber (HP:0000593)1.64720876
185Popliteal pterygium (HP:0009756)1.64497540
186Radial bowing (HP:0002986)1.64362822
187Tubulointerstitial fibrosis (HP:0005576)1.64208448
188Aplasia/Hypoplasia of the fibula (HP:0006492)1.63784277
189Progressive inability to walk (HP:0002505)1.63591375
190Renal cortical cysts (HP:0000803)1.61983210
191Reduced subcutaneous adipose tissue (HP:0003758)1.61049698

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K64.85208932
2PLK44.05251192
3ERBB43.81958269
4BRAF3.57187502
5TTK3.47921616
6MUSK3.34747744
7BMPR23.24887882
8FRK3.13952104
9LIMK13.13561724
10TAOK33.09481830
11MAP3K92.92881730
12MOS2.90554254
13LATS22.85335219
14KSR22.55954738
15LATS12.53892686
16MAP3K132.49009386
17STK38L2.44007284
18MYLK2.26897199
19ARAF2.11463862
20MAPKAPK32.10202366
21EEF2K2.09731911
22DDR21.95395077
23CDC71.89324693
24RAF11.87776302
25ZAK1.79967129
26PRKD31.75787036
27ADRBK21.73956385
28PAK31.64325211
29STK101.58276867
30MAPK131.55799326
31TGFBR11.54302232
32EPHB21.54207969
33MELK1.52561578
34CHEK21.48592267
35WNK41.47273987
36WNK31.46675321
37CDK81.45312201
38TESK11.42283999
39CDK91.40064949
40EIF2AK31.38896852
41PLK11.36718725
42TGFBR21.33510214
43TRIM281.30955842
44ADRBK11.29435521
45TLK11.27124468
46BCR1.25435100
47PRKD21.20966322
48PIK3CG1.19909510
49PRKCE1.18335245
50PTK2B1.17519246
51TAOK11.17191532
52PRKCI1.16101262
53KSR11.15549618
54STK31.07562361
55STK391.07148085
56INSRR1.05254078
57MAP2K71.02423352
58TRPM71.00415029
59TIE10.96879888
60MAP3K40.96837641
61PLK20.96666212
62NEK90.93833906
63FER0.92931566
64PAK20.92852554
65MAP3K80.92275582
66MAPKAPK50.90933647
67PRKCG0.89101663
68PAK60.87608318
69NEK60.85790498
70MAP4K20.84375234
71NEK20.83921081
72DYRK20.80771939
73TEC0.78738515
74AURKA0.76785799
75SGK20.76446535
76PLK30.76032555
77ERBB30.75167492
78PNCK0.74897810
79CSNK1G20.74487742
80DMPK0.73996950
81FLT30.73996487
82BCKDK0.72360862
83PTK20.71734923
84CSNK1A1L0.71666413
85AKT30.71568109
86PDK20.70295223
87CSNK1G30.66730269
88PIM20.66122096
89NLK0.65629288
90AURKB0.64545369
91RPS6KB20.62296980
92BMPR1B0.59393925
93MARK10.58837819
94MST40.57470452
95GRK70.57301927
96TYRO30.56538336
97NEK10.55819246
98OXSR10.55714392
99ROCK10.54487994
100ABL20.53869177
101PRKAA20.51944054
102GRK50.51863663
103GRK10.51446394
104NUAK10.51324042
105ILK0.50979004
106MAP2K20.50886557
107DAPK30.49737534
108MAP3K120.49187718
109RET0.48781058
110MET0.46692350
111MAP2K40.46230544
112CSNK1G10.45658953
113CDK30.44877723
114VRK10.44772048
115SGK4940.43956448
116SGK2230.43956448
117EPHA30.43949584
118EPHA40.40073006
119CAMK2D0.39806325
120BUB10.39554389
121ATM0.39153430
122STK240.37874475
123PRKAA10.37133430
124MAPK150.36593059
125DAPK20.36078400
126PHKG10.35978111
127PHKG20.35978111
128EIF2AK20.35623380
129MAP3K50.35541847
130SIK30.35418475
131CHUK0.34722485
132MAP3K140.34503037
133PDGFRA0.33082315
134NME10.32801216
135VRK20.32334743
136CHEK10.32121943
137BRD40.31658672
138MAP2K10.31337835
139PRKD10.30316825
140BRSK20.29219004
141TAF10.28986316
142PIM10.28093172
143MAP3K10.27102445
144CDK10.25871036
145ABL10.25575766
146CAMK2A0.24471230
147ACVR1B0.24309278
148SGK30.22056836
149AKT10.21809055
150DYRK1A0.21666901
151MAPK120.21575455
152EPHA20.20016456
153IKBKE0.19336277
154STK380.18861637
155RPS6KA40.18720954
156JAK30.18687979
157PINK10.17858621
158CASK0.17813843
159CDK70.16951012
160CDK20.16930027
161CCNB10.15661610

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049134.11770014
2RNA degradation_Homo sapiens_hsa030183.77482464
3Basal transcription factors_Homo sapiens_hsa030223.63799724
4Phototransduction_Homo sapiens_hsa047443.60150256
5Cell cycle_Homo sapiens_hsa041103.59231848
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.57444361
7Circadian rhythm_Homo sapiens_hsa047102.88920185
8Fanconi anemia pathway_Homo sapiens_hsa034602.71206873
9Homologous recombination_Homo sapiens_hsa034402.36859975
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.30476957
11Base excision repair_Homo sapiens_hsa034102.15896222
12Other glycan degradation_Homo sapiens_hsa005112.06480247
13Oocyte meiosis_Homo sapiens_hsa041142.05459394
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.01371685
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.01207353
16Linoleic acid metabolism_Homo sapiens_hsa005912.01002126
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00989345
18Pancreatic cancer_Homo sapiens_hsa052121.95780034
19Non-homologous end-joining_Homo sapiens_hsa034501.88834407
20Ether lipid metabolism_Homo sapiens_hsa005651.83965167
21TGF-beta signaling pathway_Homo sapiens_hsa043501.81624977
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.81513406
23RNA transport_Homo sapiens_hsa030131.80740189
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.80523965
25RNA polymerase_Homo sapiens_hsa030201.80348876
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.78721609
27Dorso-ventral axis formation_Homo sapiens_hsa043201.76314676
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72782499
29Oxidative phosphorylation_Homo sapiens_hsa001901.69730127
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.67642040
31p53 signaling pathway_Homo sapiens_hsa041151.67017703
32GnRH signaling pathway_Homo sapiens_hsa049121.65622323
33Nucleotide excision repair_Homo sapiens_hsa034201.60207756
34Nitrogen metabolism_Homo sapiens_hsa009101.58125030
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.58005589
36Nicotine addiction_Homo sapiens_hsa050331.55651042
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.53240504
38Mismatch repair_Homo sapiens_hsa034301.48994017
39Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.47802666
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40916759
41Vitamin B6 metabolism_Homo sapiens_hsa007501.40372768
42Malaria_Homo sapiens_hsa051441.39786968
43Selenocompound metabolism_Homo sapiens_hsa004501.33040735
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31318336
45Hedgehog signaling pathway_Homo sapiens_hsa043401.28790314
46Parkinsons disease_Homo sapiens_hsa050121.27080054
47Prolactin signaling pathway_Homo sapiens_hsa049171.22629180
48DNA replication_Homo sapiens_hsa030301.21978442
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.21083615
50Dilated cardiomyopathy_Homo sapiens_hsa054141.20599641
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.20270790
52Olfactory transduction_Homo sapiens_hsa047401.17348279
53Caffeine metabolism_Homo sapiens_hsa002321.16244323
54Morphine addiction_Homo sapiens_hsa050321.15707041
55Taste transduction_Homo sapiens_hsa047421.15163388
56MicroRNAs in cancer_Homo sapiens_hsa052061.14500836
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14403864
58Primary bile acid biosynthesis_Homo sapiens_hsa001201.11590993
59Butanoate metabolism_Homo sapiens_hsa006501.09598764
60Ras signaling pathway_Homo sapiens_hsa040141.06710731
61Huntingtons disease_Homo sapiens_hsa050161.06396035
62Sulfur relay system_Homo sapiens_hsa041221.05266205
63Tryptophan metabolism_Homo sapiens_hsa003801.05003146
64Choline metabolism in cancer_Homo sapiens_hsa052311.03119172
65Colorectal cancer_Homo sapiens_hsa052101.00857513
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99164885
67GABAergic synapse_Homo sapiens_hsa047270.98770534
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97541956
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96905673
70Focal adhesion_Homo sapiens_hsa045100.95932180
71Sulfur metabolism_Homo sapiens_hsa009200.95867791
72Cardiac muscle contraction_Homo sapiens_hsa042600.93095729
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92650717
74Arachidonic acid metabolism_Homo sapiens_hsa005900.92416178
75Long-term depression_Homo sapiens_hsa047300.92371739
76Purine metabolism_Homo sapiens_hsa002300.92220926
77Alzheimers disease_Homo sapiens_hsa050100.91103743
78Chemical carcinogenesis_Homo sapiens_hsa052040.90448462
79Steroid biosynthesis_Homo sapiens_hsa001000.89105211
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87921198
81mRNA surveillance pathway_Homo sapiens_hsa030150.87595824
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.86773506
83Pyrimidine metabolism_Homo sapiens_hsa002400.86430989
84Calcium signaling pathway_Homo sapiens_hsa040200.86221604
85Basal cell carcinoma_Homo sapiens_hsa052170.86082214
86Hippo signaling pathway_Homo sapiens_hsa043900.84545898
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82036724
88Serotonergic synapse_Homo sapiens_hsa047260.81891894
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78813088
90Thyroid cancer_Homo sapiens_hsa052160.76968734
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76481024
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76381739
93Adherens junction_Homo sapiens_hsa045200.74873570
94Peroxisome_Homo sapiens_hsa041460.74749051
95Protein digestion and absorption_Homo sapiens_hsa049740.74709754
96Sphingolipid metabolism_Homo sapiens_hsa006000.74137662
97VEGF signaling pathway_Homo sapiens_hsa043700.73038779
98Tyrosine metabolism_Homo sapiens_hsa003500.72423931
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71383270
100Glutathione metabolism_Homo sapiens_hsa004800.71351921
101FoxO signaling pathway_Homo sapiens_hsa040680.70770745
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70274997
103Retinol metabolism_Homo sapiens_hsa008300.68524018
104Regulation of autophagy_Homo sapiens_hsa041400.68345730
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68238682
106TNF signaling pathway_Homo sapiens_hsa046680.66748548
107Shigellosis_Homo sapiens_hsa051310.65816016
108N-Glycan biosynthesis_Homo sapiens_hsa005100.64187738
109Fatty acid elongation_Homo sapiens_hsa000620.63675635
110Inositol phosphate metabolism_Homo sapiens_hsa005620.63368887
111Axon guidance_Homo sapiens_hsa043600.63241218
112Metabolic pathways_Homo sapiens_hsa011000.62587046
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.61626599
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.61262583
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60047811
116Proteasome_Homo sapiens_hsa030500.58892157
117Glycerolipid metabolism_Homo sapiens_hsa005610.58716210
118Renal cell carcinoma_Homo sapiens_hsa052110.58508712
119Salivary secretion_Homo sapiens_hsa049700.57956542
120HTLV-I infection_Homo sapiens_hsa051660.57146552
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56613718
122Melanoma_Homo sapiens_hsa052180.54123812
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53129157
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52721350
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.52241492
126Arginine and proline metabolism_Homo sapiens_hsa003300.52020839
127Circadian entrainment_Homo sapiens_hsa047130.51047350
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50492152
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.50339556
130MAPK signaling pathway_Homo sapiens_hsa040100.48957425
131Propanoate metabolism_Homo sapiens_hsa006400.48476871
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46093118
133Glutamatergic synapse_Homo sapiens_hsa047240.45876098
134ECM-receptor interaction_Homo sapiens_hsa045120.44997050
135Protein export_Homo sapiens_hsa030600.43648213
136Hepatitis B_Homo sapiens_hsa051610.42063548
137Notch signaling pathway_Homo sapiens_hsa043300.41609199
138Oxytocin signaling pathway_Homo sapiens_hsa049210.41101979
139One carbon pool by folate_Homo sapiens_hsa006700.39259396
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37564194
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37154934
142Bladder cancer_Homo sapiens_hsa052190.36767020
143ErbB signaling pathway_Homo sapiens_hsa040120.34211043
144Estrogen signaling pathway_Homo sapiens_hsa049150.34017863
145Endometrial cancer_Homo sapiens_hsa052130.33866246
146Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32905232
147Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32479260
148Epstein-Barr virus infection_Homo sapiens_hsa051690.31823239
149Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31765894
150Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31463504
151Pathways in cancer_Homo sapiens_hsa052000.30622190
152Small cell lung cancer_Homo sapiens_hsa052220.30026574
153Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29921986
154Rap1 signaling pathway_Homo sapiens_hsa040150.29733755
155Influenza A_Homo sapiens_hsa051640.29626861
156Apoptosis_Homo sapiens_hsa042100.29462232
157Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28911081
158cAMP signaling pathway_Homo sapiens_hsa040240.28003648
159Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27185206
160Gap junction_Homo sapiens_hsa045400.26996016
161Herpes simplex infection_Homo sapiens_hsa051680.26412960
162Sphingolipid signaling pathway_Homo sapiens_hsa040710.26266865
163AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26082032
164Platelet activation_Homo sapiens_hsa046110.24979419

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