GPR101

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an orphan G protein-coupled receptor of unknown function. The encoded protein is a member of a family of proteins that contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.67004237
2locomotory exploration behavior (GO:0035641)5.07105574
3vocalization behavior (GO:0071625)4.83243838
4response to histamine (GO:0034776)4.82176503
5synaptic vesicle maturation (GO:0016188)4.78618023
6neuron cell-cell adhesion (GO:0007158)4.77784792
7female mating behavior (GO:0060180)4.75667168
8regulation of female receptivity (GO:0045924)4.70230004
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.56157712
10positive regulation of synaptic transmission, GABAergic (GO:0032230)4.47405794
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.45198435
12regulation of glutamate receptor signaling pathway (GO:1900449)4.38407651
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.29837552
14synaptic vesicle exocytosis (GO:0016079)4.29775335
15regulation of synaptic vesicle exocytosis (GO:2000300)4.29199113
16neurotransmitter secretion (GO:0007269)4.20981975
17gamma-aminobutyric acid signaling pathway (GO:0007214)4.19708351
18neuromuscular process controlling posture (GO:0050884)4.15164649
19neuron recognition (GO:0008038)4.14568031
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.13820013
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.10836560
22protein localization to synapse (GO:0035418)4.09155661
23regulation of glutamate secretion (GO:0014048)4.08020578
24gamma-aminobutyric acid transport (GO:0015812)4.03307224
25exploration behavior (GO:0035640)4.01958576
26transmission of nerve impulse (GO:0019226)3.89887626
27axonal fasciculation (GO:0007413)3.87762676
28neurotransmitter transport (GO:0006836)3.84894273
29layer formation in cerebral cortex (GO:0021819)3.83670153
30glutamate receptor signaling pathway (GO:0007215)3.83415046
31glutamate secretion (GO:0014047)3.81444742
32activation of protein kinase A activity (GO:0034199)3.78784806
33regulation of synaptic vesicle transport (GO:1902803)3.77563859
34regulation of protein kinase A signaling (GO:0010738)3.77454140
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.67410872
36neuronal action potential propagation (GO:0019227)3.66147434
37regulation of neuronal synaptic plasticity (GO:0048168)3.65783776
38positive regulation of catecholamine secretion (GO:0033605)3.61168340
39mating behavior (GO:0007617)3.57269421
40positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.54234720
41regulation of transmission of nerve impulse (GO:0051969)3.53461501
42dendritic spine morphogenesis (GO:0060997)3.52656875
43cellular potassium ion homeostasis (GO:0030007)3.51932829
44negative regulation of amino acid transport (GO:0051956)3.50091277
45proline transport (GO:0015824)3.50072311
46positive regulation of synapse assembly (GO:0051965)3.47792664
47positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.46136880
48negative regulation of synaptic transmission, GABAergic (GO:0032229)3.44649223
49social behavior (GO:0035176)3.43695990
50intraspecies interaction between organisms (GO:0051703)3.43695990
51long-term memory (GO:0007616)3.43410992
52regulation of neurotransmitter levels (GO:0001505)3.39257583
53drinking behavior (GO:0042756)3.34695123
54prepulse inhibition (GO:0060134)3.33831820
55synaptic transmission, glutamatergic (GO:0035249)3.33585347
56neuron-neuron synaptic transmission (GO:0007270)3.33167818
57positive regulation of amine transport (GO:0051954)3.30960455
58neuronal ion channel clustering (GO:0045161)3.26866893
59negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.24013327
60vesicle transport along microtubule (GO:0047496)3.21395636
61neurotransmitter catabolic process (GO:0042135)3.18698796
62sodium ion export (GO:0071436)3.18093008
63regulation of vesicle fusion (GO:0031338)3.17688719
64respiratory system process (GO:0003016)3.16263168
65regulation of synaptic transmission, GABAergic (GO:0032228)3.14611661
66neurotransmitter-gated ion channel clustering (GO:0072578)3.14489155
67positive regulation of amino acid transport (GO:0051957)3.12658664
68grooming behavior (GO:0007625)3.12446992
69postsynaptic membrane organization (GO:0001941)3.10425956
70adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.09233333
71regulation of beta-amyloid formation (GO:1902003)3.09167817
72aggressive behavior (GO:0002118)3.06578053
73presynaptic membrane assembly (GO:0097105)3.01764726
74positive regulation of potassium ion transmembrane transport (GO:1901381)3.01372616
75cerebellar Purkinje cell layer development (GO:0021680)2.99922489
76regulation of excitatory postsynaptic membrane potential (GO:0060079)2.96842390
77cerebellar Purkinje cell differentiation (GO:0021702)2.96600711
78glycine transport (GO:0015816)2.95390346
79membrane depolarization during action potential (GO:0086010)2.93959668
80neuromuscular process controlling balance (GO:0050885)2.93618618
81suckling behavior (GO:0001967)2.92943678
82response to auditory stimulus (GO:0010996)2.92718470
83multi-organism reproductive behavior (GO:0044705)2.92624528
84behavioral defense response (GO:0002209)2.92228212
85behavioral fear response (GO:0001662)2.92228212
86maternal behavior (GO:0042711)2.92189409
87membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.89856517
88opioid receptor signaling pathway (GO:0038003)2.87968628
89regulation of synaptic transmission, glutamatergic (GO:0051966)2.87638254
90regulation of synapse structural plasticity (GO:0051823)2.87619612
91presynaptic membrane organization (GO:0097090)2.86325749
92positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.85215566
93synapse assembly (GO:0007416)2.84791267
94regulation of amyloid precursor protein catabolic process (GO:1902991)2.83542472
95regulation of postsynaptic membrane potential (GO:0060078)2.82792377
96membrane hyperpolarization (GO:0060081)2.82274753
97positive regulation of membrane potential (GO:0045838)2.81366675
98mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.80730272
99regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.80702003
100mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.80607719

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.46363626
2GBX2_23144817_ChIP-Seq_PC3_Human3.19246646
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07272479
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06293757
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93503999
6REST_21632747_ChIP-Seq_MESCs_Mouse2.75983962
7* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61808505
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56112341
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55568441
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.54357658
11TAF15_26573619_Chip-Seq_HEK293_Human2.52977222
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51262828
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51262828
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50278506
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48095912
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47664996
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.46796642
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.43073570
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.38207500
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.20588112
21* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17961756
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.16080414
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.12179181
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11359741
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11251620
26DROSHA_22980978_ChIP-Seq_HELA_Human2.11015266
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.02312638
28AR_21572438_ChIP-Seq_LNCaP_Human1.90022625
29* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89223799
30* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88490928
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82109531
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.79170108
33ZNF274_21170338_ChIP-Seq_K562_Hela1.66106982
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62969335
35P300_19829295_ChIP-Seq_ESCs_Human1.61974376
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61215831
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60761523
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48733706
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45590324
40IGF1R_20145208_ChIP-Seq_DFB_Human1.41260663
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40705241
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38403623
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.38321354
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37687684
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.36985884
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.36209947
47AR_25329375_ChIP-Seq_VCAP_Human1.35657324
48* SMAD3_21741376_ChIP-Seq_EPCs_Human1.32573597
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32564763
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.30238396
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28144614
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27940453
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.27656671
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27652654
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.26985152
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26258991
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26035919
58* RNF2_27304074_Chip-Seq_NSC_Mouse1.25252969
59* ER_23166858_ChIP-Seq_MCF-7_Human1.23518927
60ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20283730
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19990842
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18994347
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18861506
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17271376
65FUS_26573619_Chip-Seq_HEK293_Human1.16410316
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16036645
67STAT3_23295773_ChIP-Seq_U87_Human1.15311422
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13141010
69MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12968539
70RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12939935
71AR_19668381_ChIP-Seq_PC3_Human1.10049258
72* RUNX2_22187159_ChIP-Seq_PCA_Human1.08624754
73TCF4_23295773_ChIP-Seq_U87_Human1.06452778
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06249341
75* JUN_21703547_ChIP-Seq_K562_Human1.05650279
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04015195
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.03146285
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02538608
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02357097
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99584801
81P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98687572
82AHR_22903824_ChIP-Seq_MCF-7_Human0.97959694
83STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96611518
84WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94917559
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92008676
86SMAD3_21741376_ChIP-Seq_ESCs_Human0.91581883
87RING1B_27294783_Chip-Seq_NPCs_Mouse0.90163313
88CBP_20019798_ChIP-Seq_JUKART_Human0.89537324
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89537324
90SMAD4_21741376_ChIP-Seq_HESCs_Human0.89415693
91TP53_18474530_ChIP-ChIP_U2OS_Human0.88374322
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88095967
93PRDM14_20953172_ChIP-Seq_ESCs_Human0.87681570
94YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87418136
95TP53_16413492_ChIP-PET_HCT116_Human0.87211663
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86761320
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85379769
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85306428
99SMAD4_21741376_ChIP-Seq_EPCs_Human0.85276114
100CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83240487

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.41791633
2MP0004859_abnormal_synaptic_plasticity4.71986463
3MP0003122_maternal_imprinting3.82244555
4MP0003635_abnormal_synaptic_transmissio3.62915350
5MP0001968_abnormal_touch/_nociception3.57482704
6MP0005645_abnormal_hypothalamus_physiol3.55633453
7MP0009745_abnormal_behavioral_response3.36158984
8MP0006276_abnormal_autonomic_nervous3.26815606
9MP0009046_muscle_twitch3.14887295
10MP0002064_seizures3.14362798
11MP0002063_abnormal_learning/memory/cond2.84948103
12MP0005423_abnormal_somatic_nervous2.84078276
13MP0001440_abnormal_grooming_behavior2.80897951
14MP0002572_abnormal_emotion/affect_behav2.67771083
15MP0004270_analgesia2.54155169
16MP0001501_abnormal_sleep_pattern2.46371332
17MP0002736_abnormal_nociception_after2.43775227
18MP0002272_abnormal_nervous_system2.41680574
19MP0005646_abnormal_pituitary_gland2.35440109
20MP0002734_abnormal_mechanical_nocicepti2.23300546
21MP0001486_abnormal_startle_reflex2.17946290
22MP0003123_paternal_imprinting2.07354277
23MP0002067_abnormal_sensory_capabilities1.98942531
24MP0004142_abnormal_muscle_tone1.95280003
25MP0002733_abnormal_thermal_nociception1.95071727
26MP0002735_abnormal_chemical_nociception1.93438853
27MP0003329_amyloid_beta_deposits1.92658147
28MP0001970_abnormal_pain_threshold1.90606068
29MP0002557_abnormal_social/conspecific_i1.78391596
30MP0003787_abnormal_imprinting1.77358084
31MP0003121_genomic_imprinting1.75312298
32MP0004924_abnormal_behavior1.72611745
33MP0005386_behavior/neurological_phenoty1.72611745
34MP0002822_catalepsy1.66600613
35MP0001502_abnormal_circadian_rhythm1.64783651
36MP0001529_abnormal_vocalization1.62325015
37MP0000751_myopathy1.58211391
38MP0001905_abnormal_dopamine_level1.55495315
39MP0003690_abnormal_glial_cell1.54552085
40MP0003283_abnormal_digestive_organ1.50795433
41MP0001984_abnormal_olfaction1.47409982
42MP0008569_lethality_at_weaning1.42900502
43MP0002909_abnormal_adrenal_gland1.42464029
44MP0009780_abnormal_chondrocyte_physiolo1.42168824
45MP0002184_abnormal_innervation1.39392607
46MP0000778_abnormal_nervous_system1.34185016
47MP0004145_abnormal_muscle_electrophysio1.29384936
48MP0002066_abnormal_motor_capabilities/c1.29351377
49MP0004885_abnormal_endolymph1.28014411
50MP0004811_abnormal_neuron_physiology1.21282230
51MP0000013_abnormal_adipose_tissue1.21186942
52MP0003633_abnormal_nervous_system1.20924584
53MP0002882_abnormal_neuron_morphology1.16014890
54MP0004858_abnormal_nervous_system1.14055352
55MP0008872_abnormal_physiological_respon1.12461089
56MP0000955_abnormal_spinal_cord1.12192729
57MP0002837_dystrophic_cardiac_calcinosis1.06631962
58MP0006072_abnormal_retinal_apoptosis1.02904796
59MP0000604_amyloidosis1.01201888
60MP0002069_abnormal_eating/drinking_beha0.98143736
61MP0003631_nervous_system_phenotype0.95344493
62MP0002876_abnormal_thyroid_physiology0.94820646
63MP0005551_abnormal_eye_electrophysiolog0.93156930
64MP0003634_abnormal_glial_cell0.92699933
65MP0005623_abnormal_meninges_morphology0.92661841
66MP0000920_abnormal_myelination0.91996295
67MP0004742_abnormal_vestibular_system0.91007306
68MP0002229_neurodegeneration0.90371424
69MP0000631_abnormal_neuroendocrine_gland0.89163802
70MP0002152_abnormal_brain_morphology0.88365468
71MP0008874_decreased_physiological_sensi0.86496293
72MP0000747_muscle_weakness0.82972605
73MP0005379_endocrine/exocrine_gland_phen0.79935974
74MP0003879_abnormal_hair_cell0.79558945
75MP0008961_abnormal_basal_metabolism0.79146592
76MP0001177_atelectasis0.77655435
77MP0005535_abnormal_body_temperature0.73994949
78MP0004215_abnormal_myocardial_fiber0.72357678
79MP0004085_abnormal_heartbeat0.72164310
80MP0003959_abnormal_lean_body0.71090627
81MP0003137_abnormal_impulse_conducting0.69231426
82MP0005448_abnormal_energy_balance0.69157132
83MP0001188_hyperpigmentation0.68990878
84MP0001299_abnormal_eye_distance/0.68675490
85MP0003075_altered_response_to0.67924131
86MP0001963_abnormal_hearing_physiology0.67469678
87MP0005253_abnormal_eye_physiology0.64861696
88MP0000639_abnormal_adrenal_gland0.64031505
89MP0003632_abnormal_nervous_system0.62915852
90MP0002638_abnormal_pupillary_reflex0.61584608
91MP0002752_abnormal_somatic_nervous0.61440407
92MP0008877_abnormal_DNA_methylation0.60020546
93MP0002090_abnormal_vision0.58809689
94MP0001943_abnormal_respiration0.56234758
95MP0005499_abnormal_olfactory_system0.50906457
96MP0005394_taste/olfaction_phenotype0.50906457
97MP0005452_abnormal_adipose_tissue0.50234515
98MP0005167_abnormal_blood-brain_barrier0.49804621
99MP0000230_abnormal_systemic_arterial0.49746690
100MP0010234_abnormal_vibrissa_follicle0.49742122

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.22491152
2Focal seizures (HP:0007359)5.27208074
3Atonic seizures (HP:0010819)5.14932532
4Myokymia (HP:0002411)4.69231782
5Absence seizures (HP:0002121)4.51386683
6Visual hallucinations (HP:0002367)4.30359155
7Dialeptic seizures (HP:0011146)4.08535536
8Generalized tonic-clonic seizures (HP:0002069)4.06019713
9Abnormal eating behavior (HP:0100738)4.03859378
10Polyphagia (HP:0002591)4.01431315
11Febrile seizures (HP:0002373)3.96678957
12Epileptic encephalopathy (HP:0200134)3.78621694
13Abnormal ciliary motility (HP:0012262)3.76937320
14Progressive cerebellar ataxia (HP:0002073)3.73947860
15Supranuclear gaze palsy (HP:0000605)3.71596730
16Anxiety (HP:0000739)3.39859479
17Neurofibrillary tangles (HP:0002185)3.36405277
18Papilledema (HP:0001085)3.30509543
19Agitation (HP:0000713)3.27765473
20Abnormal respiratory motile cilium physiology (HP:0012261)3.18011553
21Truncal ataxia (HP:0002078)3.12881710
22Abnormal respiratory motile cilium morphology (HP:0005938)3.11654640
23Abnormal respiratory epithelium morphology (HP:0012253)3.11654640
24Broad-based gait (HP:0002136)3.05803326
25Depression (HP:0000716)3.05599702
26Failure to thrive in infancy (HP:0001531)2.95776720
27Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.91758223
28Pheochromocytoma (HP:0002666)2.87778758
29Dysmetria (HP:0001310)2.86144236
30Mutism (HP:0002300)2.83841990
31Dysdiadochokinesis (HP:0002075)2.80883105
32Hemiparesis (HP:0001269)2.74850206
33Impaired vibration sensation in the lower limbs (HP:0002166)2.74283937
34Action tremor (HP:0002345)2.71431146
35Absent/shortened dynein arms (HP:0200106)2.71426859
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.71426859
37Psychosis (HP:0000709)2.71195292
38Progressive inability to walk (HP:0002505)2.67905600
39Cerebral inclusion bodies (HP:0100314)2.66917387
40Poor eye contact (HP:0000817)2.66544410
41Postural instability (HP:0002172)2.66180133
42Drooling (HP:0002307)2.64409670
43Excessive salivation (HP:0003781)2.64409670
44Ankle clonus (HP:0011448)2.61719683
45Neuroendocrine neoplasm (HP:0100634)2.56870595
46Rhinitis (HP:0012384)2.52886223
47Impaired social interactions (HP:0000735)2.52393771
48Abnormal social behavior (HP:0012433)2.52393771
49Hypoventilation (HP:0002791)2.49909400
50Abnormal hair whorl (HP:0010721)2.36484526
51Hyperthyroidism (HP:0000836)2.33897611
52Hyperventilation (HP:0002883)2.33696517
53Urinary bladder sphincter dysfunction (HP:0002839)2.33141359
54Diplopia (HP:0000651)2.30051350
55Abnormality of binocular vision (HP:0011514)2.30051350
56Esotropia (HP:0000565)2.30039721
57Menstrual irregularities (HP:0000858)2.29868469
58Abnormality of the corticospinal tract (HP:0002492)2.29085755
59Status epilepticus (HP:0002133)2.28011796
60Termporal pattern (HP:0011008)2.27375669
61Insidious onset (HP:0003587)2.27375669
62Blue irides (HP:0000635)2.25490581
63Abnormality of the labia minora (HP:0012880)2.25341595
64Spastic gait (HP:0002064)2.24776979
65Fetal akinesia sequence (HP:0001989)2.24164019
66Scanning speech (HP:0002168)2.20218653
67Bradykinesia (HP:0002067)2.19545774
68Neuronal loss in central nervous system (HP:0002529)2.17559901
69Sleep apnea (HP:0010535)2.13681488
70Hemiplegia (HP:0002301)2.12648215
71Ventricular fibrillation (HP:0001663)2.10954089
72Ankyloglossia (HP:0010296)2.09956907
73Urinary urgency (HP:0000012)2.06994438
74Narrow nasal bridge (HP:0000446)2.06993873
75Oligomenorrhea (HP:0000876)2.06470705
76Specific learning disability (HP:0001328)2.05356310
77Abnormal EKG (HP:0003115)2.04916136
78Poor suck (HP:0002033)2.04158945
79Postural tremor (HP:0002174)2.03007969
80Diaphragmatic weakness (HP:0009113)2.02748586
81Peripheral hypomyelination (HP:0007182)2.02090300
82Generalized myoclonic seizures (HP:0002123)2.02063625
83Lower limb muscle weakness (HP:0007340)2.01436886
84Hypoglycemic seizures (HP:0002173)2.00635765
85Amblyopia (HP:0000646)1.95747245
86Gait imbalance (HP:0002141)1.94888947
87Gaze-evoked nystagmus (HP:0000640)1.94518736
88Abnormality of pain sensation (HP:0010832)1.93109813
89Impaired pain sensation (HP:0007328)1.93109813
90Anosmia (HP:0000458)1.92355326
91Intention tremor (HP:0002080)1.91601907
92Aplasia involving bones of the upper limbs (HP:0009823)1.90525459
93Aplasia of the phalanges of the hand (HP:0009802)1.90525459
94Aplasia involving bones of the extremities (HP:0009825)1.90525459
95Prolonged QT interval (HP:0001657)1.87959404
96Epileptiform EEG discharges (HP:0011182)1.86904468
97Genetic anticipation (HP:0003743)1.86854361
98EEG with generalized epileptiform discharges (HP:0011198)1.86253523
99Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.82918803
100Degeneration of the lateral corticospinal tracts (HP:0002314)1.82918803

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.30595126
2MAP3K93.80661084
3PNCK3.44602882
4MAP3K123.44297486
5MAP3K43.13773832
6NTRK22.91191391
7EPHA42.70697982
8MARK12.57794342
9MINK12.55910357
10MAP2K72.36361708
11MAP2K42.33539255
12TNIK2.22031815
13NTRK12.12192494
14ARAF1.96045897
15FES1.79598708
16KSR21.76137237
17TNK21.69208879
18PAK61.67511518
19MAP3K131.62187783
20UHMK11.49902469
21CASK1.45493998
22CDK51.41983423
23PAK31.34990532
24GRK71.22817962
25WNK31.19971262
26MAPK131.15793158
27CAMK2A1.15404752
28PRKCG1.14152095
29OXSR11.13923607
30CAMK1G1.11934525
31ADRBK21.10971600
32CAMKK11.10649899
33CDK191.08539566
34PRKCH1.08490058
35TYRO31.07673937
36LATS21.04269330
37KSR11.02806344
38STK391.02741670
39STK381.00782014
40SIK21.00558304
41PHKG10.98227839
42PHKG20.98227839
43RIPK40.93348978
44FER0.92342583
45MAP3K20.92150635
46GRK50.91191291
47DAPK20.88735477
48CAMK2B0.87074137
49CAMK10.87005529
50CAMKK20.84732612
51NME10.82349985
52SGK4940.81696366
53SGK2230.81696366
54CAMK2D0.78844532
55STK110.75276914
56PLK20.73943331
57AKT30.73210771
58CDK140.70699940
59ADRBK10.68666556
60MAP3K10.68649385
61CAMK2G0.67457709
62LMTK20.66952586
63RET0.63977470
64MOS0.61426402
65CDK180.61140398
66CDK150.60426733
67SGK10.60258993
68PRKD30.59785625
69SCYL20.58960737
70ALK0.57777166
71RAF10.57217199
72DAPK10.57066718
73PINK10.56366150
74PRKCE0.55872095
75TSSK60.55101023
76RPS6KA30.54822036
77BCR0.54788132
78CDC42BPA0.53846621
79CSNK1G20.53601942
80WNK40.53449423
81MAPK100.52572297
82WNK10.52379895
83NEK60.52216016
84ROCK20.51141101
85CDK11A0.48273285
86MAPKAPK50.47850312
87PKN10.46652886
88FYN0.46216703
89PDPK10.45247546
90FGFR20.44299441
91PRKACA0.43326472
92CSNK1E0.42451081
93SGK20.42232895
94PRKG10.40527231
95PRKCA0.39772554
96IRAK20.39246897
97PDK10.38504814
98PRKACG0.36190546
99PRKCB0.36015377
100FGR0.35625683

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.73983306
2GABAergic synapse_Homo sapiens_hsa047273.44896351
3Synaptic vesicle cycle_Homo sapiens_hsa047212.94572127
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.91063161
5Morphine addiction_Homo sapiens_hsa050322.74805406
6Olfactory transduction_Homo sapiens_hsa047402.41427682
7Circadian entrainment_Homo sapiens_hsa047132.40519191
8Glutamatergic synapse_Homo sapiens_hsa047242.39928716
9Long-term potentiation_Homo sapiens_hsa047202.19328728
10Amphetamine addiction_Homo sapiens_hsa050312.08933467
11Oxidative phosphorylation_Homo sapiens_hsa001902.04729219
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.02470437
13Taste transduction_Homo sapiens_hsa047422.01059157
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.94086715
15Salivary secretion_Homo sapiens_hsa049701.91699526
16Collecting duct acid secretion_Homo sapiens_hsa049661.88794230
17Dopaminergic synapse_Homo sapiens_hsa047281.87304340
18Serotonergic synapse_Homo sapiens_hsa047261.84995057
19Renin secretion_Homo sapiens_hsa049241.79167581
20Cocaine addiction_Homo sapiens_hsa050301.77627355
21Gastric acid secretion_Homo sapiens_hsa049711.75215629
22Cardiac muscle contraction_Homo sapiens_hsa042601.74629250
23Long-term depression_Homo sapiens_hsa047301.74435170
24Insulin secretion_Homo sapiens_hsa049111.71169285
25Parkinsons disease_Homo sapiens_hsa050121.60680439
26Cholinergic synapse_Homo sapiens_hsa047251.54423371
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51223820
28Alzheimers disease_Homo sapiens_hsa050101.47527347
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45800475
30Oxytocin signaling pathway_Homo sapiens_hsa049211.41837581
31Calcium signaling pathway_Homo sapiens_hsa040201.40402386
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38883502
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34355555
34Vibrio cholerae infection_Homo sapiens_hsa051101.30943953
35GnRH signaling pathway_Homo sapiens_hsa049121.27406884
36Nitrogen metabolism_Homo sapiens_hsa009101.23077123
37Estrogen signaling pathway_Homo sapiens_hsa049151.22336014
38Huntingtons disease_Homo sapiens_hsa050161.19248709
39Gap junction_Homo sapiens_hsa045401.18714261
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13561094
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12482588
42cAMP signaling pathway_Homo sapiens_hsa040241.09010085
43Dorso-ventral axis formation_Homo sapiens_hsa043201.07216302
44Type II diabetes mellitus_Homo sapiens_hsa049301.02190932
45Type I diabetes mellitus_Homo sapiens_hsa049401.02151080
46Melanogenesis_Homo sapiens_hsa049160.98491055
47Axon guidance_Homo sapiens_hsa043600.88487984
48Thyroid hormone synthesis_Homo sapiens_hsa049180.86927580
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.83259796
50Prion diseases_Homo sapiens_hsa050200.83063426
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81513066
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80762631
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79801875
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76670257
55Dilated cardiomyopathy_Homo sapiens_hsa054140.76092031
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75249782
57Pancreatic secretion_Homo sapiens_hsa049720.72570502
58Bile secretion_Homo sapiens_hsa049760.72441841
59Butanoate metabolism_Homo sapiens_hsa006500.71193468
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70784581
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70122705
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.67260405
63ErbB signaling pathway_Homo sapiens_hsa040120.65954974
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64997124
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64604067
66Oocyte meiosis_Homo sapiens_hsa041140.63689432
67Glioma_Homo sapiens_hsa052140.59255172
68Phototransduction_Homo sapiens_hsa047440.58103345
69MAPK signaling pathway_Homo sapiens_hsa040100.56231436
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48298055
71Ovarian steroidogenesis_Homo sapiens_hsa049130.48230972
72Alcoholism_Homo sapiens_hsa050340.47609667
73Choline metabolism in cancer_Homo sapiens_hsa052310.46828481
74Ras signaling pathway_Homo sapiens_hsa040140.42886983
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40230440
76Glucagon signaling pathway_Homo sapiens_hsa049220.39917618
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.39231771
78Rheumatoid arthritis_Homo sapiens_hsa053230.38929489
79Renal cell carcinoma_Homo sapiens_hsa052110.37904522
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36857354
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36793259
82Ether lipid metabolism_Homo sapiens_hsa005650.28720629
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28527631
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28525175
85Insulin signaling pathway_Homo sapiens_hsa049100.27754897
86Arginine biosynthesis_Homo sapiens_hsa002200.27038039
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.26951324
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26747286
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26169775
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24860515
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24070358
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22843593
93Rap1 signaling pathway_Homo sapiens_hsa040150.21823903
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.21371007
95Inositol phosphate metabolism_Homo sapiens_hsa005620.19485810
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18572777
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.16432564
98VEGF signaling pathway_Homo sapiens_hsa043700.16291285
99Fatty acid biosynthesis_Homo sapiens_hsa000610.15519303
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.14937081

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