

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.33955426 |
| 2 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 5.33146931 |
| 3 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 5.33146931 |
| 4 | antigen processing and presentation of endogenous antigen (GO:0019883) | 4.81293137 |
| 5 | Golgi transport vesicle coating (GO:0048200) | 4.70553955 |
| 6 | COPI coating of Golgi vesicle (GO:0048205) | 4.70553955 |
| 7 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 4.45630203 |
| 8 | negative regulation of cell killing (GO:0031342) | 4.45630203 |
| 9 | positive regulation of gamma-delta T cell activation (GO:0046645) | 3.96251265 |
| 10 | signal peptide processing (GO:0006465) | 3.74759786 |
| 11 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 3.64154200 |
| 12 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.56139785 |
| 13 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.49199166 |
| 14 | neutrophil activation involved in immune response (GO:0002283) | 3.46784633 |
| 15 | protein retention in ER lumen (GO:0006621) | 3.44177932 |
| 16 | positive regulation of natural killer cell differentiation (GO:0032825) | 3.34060370 |
| 17 | growth hormone receptor signaling pathway (GO:0060396) | 3.30051190 |
| 18 | response to type I interferon (GO:0034340) | 3.20773743 |
| 19 | type I interferon signaling pathway (GO:0060337) | 3.19062740 |
| 20 | cellular response to type I interferon (GO:0071357) | 3.19062740 |
| 21 | leukotriene biosynthetic process (GO:0019370) | 3.17189625 |
| 22 | cellular response to interferon-beta (GO:0035458) | 3.14734897 |
| 23 | response to interferon-beta (GO:0035456) | 3.13217713 |
| 24 | response to peptidoglycan (GO:0032494) | 3.11202810 |
| 25 | negative regulation of interleukin-12 production (GO:0032695) | 3.11158909 |
| 26 | valine metabolic process (GO:0006573) | 3.09925561 |
| 27 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.09117740 |
| 28 | positive regulation of interferon-alpha production (GO:0032727) | 3.03654825 |
| 29 | immunoglobulin mediated immune response (GO:0016064) | 3.03139264 |
| 30 | regulation of mast cell degranulation (GO:0043304) | 3.00168449 |
| 31 | amyloid precursor protein catabolic process (GO:0042987) | 2.99709778 |
| 32 | cellular response to growth hormone stimulus (GO:0071378) | 2.95721385 |
| 33 | regulation of gamma-delta T cell activation (GO:0046643) | 2.91676568 |
| 34 | regulation of interferon-alpha production (GO:0032647) | 2.86955046 |
| 35 | positive regulation of B cell differentiation (GO:0045579) | 2.86135247 |
| 36 | sequestering of metal ion (GO:0051238) | 2.85140403 |
| 37 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 2.84925886 |
| 38 | regulation of leukocyte degranulation (GO:0043300) | 2.83037714 |
| 39 | COPII vesicle coating (GO:0048208) | 2.81463640 |
| 40 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 2.80248756 |
| 41 | leukotriene metabolic process (GO:0006691) | 2.79288804 |
| 42 | respiratory burst (GO:0045730) | 2.78744384 |
| 43 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.77808027 |
| 44 | retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) | 2.77405441 |
| 45 | regulation of RIG-I signaling pathway (GO:0039535) | 2.75900153 |
| 46 | regulation of natural killer cell differentiation (GO:0032823) | 2.75611859 |
| 47 | response to interferon-alpha (GO:0035455) | 2.75493195 |
| 48 | modulation by symbiont of host defense response (GO:0052031) | 2.74916056 |
| 49 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 2.74916056 |
| 50 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 2.74916056 |
| 51 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 2.74916056 |
| 52 | modulation by symbiont of host immune response (GO:0052553) | 2.74916056 |
| 53 | positive regulation by symbiont of host defense response (GO:0052509) | 2.74916056 |
| 54 | peptide catabolic process (GO:0043171) | 2.73769605 |
| 55 | positive regulation of antigen processing and presentation (GO:0002579) | 2.73461241 |
| 56 | negative regulation of cytokine production involved in immune response (GO:0002719) | 2.69275754 |
| 57 | regulation of B cell receptor signaling pathway (GO:0050855) | 2.68423139 |
| 58 | response to protozoan (GO:0001562) | 2.67444144 |
| 59 | regulation of mast cell activation involved in immune response (GO:0033006) | 2.67160406 |
| 60 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 2.67045581 |
| 61 | defense response to protozoan (GO:0042832) | 2.66789630 |
| 62 | regulation of superoxide anion generation (GO:0032928) | 2.65526161 |
| 63 | germinal center formation (GO:0002467) | 2.64655730 |
| 64 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 2.62678382 |
| 65 | cellular response to zinc ion (GO:0071294) | 2.61608579 |
| 66 | myeloid cell activation involved in immune response (GO:0002275) | 2.61293619 |
| 67 | production of molecular mediator involved in inflammatory response (GO:0002532) | 2.60624853 |
| 68 | barbed-end actin filament capping (GO:0051016) | 2.58911171 |
| 69 | leukocyte aggregation (GO:0070486) | 2.58658064 |
| 70 | negative regulation of innate immune response (GO:0045824) | 2.58123481 |
| 71 | mannose metabolic process (GO:0006013) | 2.57505469 |
| 72 | negative regulation of leukocyte mediated immunity (GO:0002704) | 2.56424406 |
| 73 | pinocytosis (GO:0006907) | 2.55063762 |
| 74 | T cell migration (GO:0072678) | 2.52747206 |
| 75 | myeloid dendritic cell differentiation (GO:0043011) | 2.50592808 |
| 76 | positive regulation of chemokine biosynthetic process (GO:0045080) | 2.50589447 |
| 77 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 2.50534849 |
| 78 | response to host immune response (GO:0052572) | 2.50534849 |
| 79 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 2.50503205 |
| 80 | negative regulation of myeloid cell apoptotic process (GO:0033033) | 2.50439045 |
| 81 | activation of signaling protein activity involved in unfolded protein response (GO:0006987) | 2.50305878 |
| 82 | glycosphingolipid catabolic process (GO:0046479) | 2.48967979 |
| 83 | regulation of chemokine biosynthetic process (GO:0045073) | 2.48349188 |
| 84 | regulation of B cell differentiation (GO:0045577) | 2.48248147 |
| 85 | tolerance induction (GO:0002507) | 2.47167173 |
| 86 | B cell mediated immunity (GO:0019724) | 2.46774532 |
| 87 | amino sugar catabolic process (GO:0046348) | 2.45760609 |
| 88 | regulation of T-helper 2 cell differentiation (GO:0045628) | 2.45244464 |
| 89 | detection of other organism (GO:0098543) | 2.43706280 |
| 90 | regulation of T cell mediated cytotoxicity (GO:0001914) | 2.42467773 |
| 91 | response to host (GO:0075136) | 2.42309983 |
| 92 | response to host defenses (GO:0052200) | 2.42309983 |
| 93 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 2.42309983 |
| 94 | cellular extravasation (GO:0045123) | 2.41579260 |
| 95 | positive regulation of tumor necrosis factor production (GO:0032760) | 2.41497974 |
| 96 | positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557) | 2.41443171 |
| 97 | membrane protein intracellular domain proteolysis (GO:0031293) | 2.41406919 |
| 98 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 2.41348120 |
| 99 | neutrophil activation (GO:0042119) | 2.41173703 |
| 100 | positive regulation of natural killer cell activation (GO:0032816) | 2.40374249 |
| 101 | hydrogen peroxide biosynthetic process (GO:0050665) | 2.40303151 |
| 102 | positive regulation of nuclease activity (GO:0032075) | 2.40262033 |
| 103 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 2.40157833 |
| 104 | endoplasmic reticulum unfolded protein response (GO:0030968) | 2.39937031 |
| 105 | regulation of natural killer cell mediated immunity (GO:0002715) | 2.39328917 |
| 106 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 2.39328917 |
| 107 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 2.38895639 |
| 108 | lipoxygenase pathway (GO:0019372) | 2.38684672 |
| 109 | ER-associated ubiquitin-dependent protein catabolic process (GO:0030433) | 2.38531726 |
| 110 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 2.38220300 |
| 111 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 2.37862053 |
| 112 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.37690656 |
| 113 | positive regulation of Cdc42 GTPase activity (GO:0043089) | 2.37434249 |
| 114 | reactive oxygen species biosynthetic process (GO:1903409) | 2.36757091 |
| 115 | regulation of syncytium formation by plasma membrane fusion (GO:0060142) | 2.36680948 |
| 116 | regulation of antigen processing and presentation (GO:0002577) | 2.36547214 |
| 117 | positive regulation of syncytium formation by plasma membrane fusion (GO:0060143) | 2.36149883 |
| 118 | leukocyte degranulation (GO:0043299) | 2.35981719 |
| 119 | detection of biotic stimulus (GO:0009595) | 2.35958584 |
| 120 | macrophage activation involved in immune response (GO:0002281) | 2.35447854 |
| 121 | regulation of response to interferon-gamma (GO:0060330) | 2.34795426 |
| 122 | response to interleukin-15 (GO:0070672) | 2.34747937 |
| 123 | NIK/NF-kappaB signaling (GO:0038061) | 2.33923767 |
| 124 | apoptotic cell clearance (GO:0043277) | 2.32862407 |
| 125 | cellular response to unfolded protein (GO:0034620) | 2.32708792 |
| 126 | lymphocyte chemotaxis (GO:0048247) | 2.31104175 |
| 127 | negative thymic T cell selection (GO:0045060) | 2.30826270 |
| 128 | negative regulation of bone resorption (GO:0045779) | 2.30157113 |
| 129 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 2.29925590 |
| 130 | cellular response to interleukin-15 (GO:0071350) | 2.29221079 |
| 131 | response to muramyl dipeptide (GO:0032495) | 2.28661256 |
| 132 | protein localization to endosome (GO:0036010) | 2.28333821 |
| 133 | detection of external biotic stimulus (GO:0098581) | 2.28175411 |
| 134 | regulation of T cell tolerance induction (GO:0002664) | 2.27578550 |
| 135 | positive regulation of mast cell activation (GO:0033005) | 2.27547783 |
| 136 | positive regulation of macrophage differentiation (GO:0045651) | 2.26885537 |
| 137 | negative regulation of lipid storage (GO:0010888) | 2.26792024 |
| 138 | glycolipid catabolic process (GO:0019377) | 2.26787179 |
| 139 | positive regulation of membrane protein ectodomain proteolysis (GO:0051044) | 2.26706801 |
| 140 | myeloid dendritic cell activation (GO:0001773) | 2.25990399 |
| 141 | negative regulation of erythrocyte differentiation (GO:0045647) | 2.25806002 |
| 142 | positive regulation of monocyte chemotaxis (GO:0090026) | 2.25766469 |
| 143 | positive regulation of cellular amide metabolic process (GO:0034250) | 2.25603765 |
| 144 | regulation of natural killer cell activation (GO:0032814) | 2.25248330 |
| 145 | regulation of type 2 immune response (GO:0002828) | 2.24339216 |
| 146 | cellular response to thyroid hormone stimulus (GO:0097067) | 2.23922119 |
| 147 | mitochondrial calcium ion transport (GO:0006851) | 2.23283489 |
| 148 | granulocyte activation (GO:0036230) | 2.22706407 |
| 149 | detection of molecule of bacterial origin (GO:0032490) | 2.22079781 |
| 150 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 2.21661897 |
| 151 | neutrophil mediated immunity (GO:0002446) | 2.21547327 |
| 152 | detection of bacterium (GO:0016045) | 2.21039088 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 4.98349804 |
| 2 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 4.05355990 |
| 3 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 3.49285840 |
| 4 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.39808897 |
| 5 | GATA1_22025678_ChIP-Seq_K562_Human | 3.08971536 |
| 6 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.82158126 |
| 7 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.81474202 |
| 8 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.57228464 |
| 9 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 2.57106028 |
| 10 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.54454539 |
| 11 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.51247724 |
| 12 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.48825829 |
| 13 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.44290362 |
| 14 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.40220935 |
| 15 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 2.38676844 |
| 16 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.34880417 |
| 17 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.34333928 |
| 18 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 2.21726022 |
| 19 | * SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.16533844 |
| 20 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.95163488 |
| 21 | * RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.89574114 |
| 22 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.88329002 |
| 23 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.84047196 |
| 24 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.83839756 |
| 25 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.82775405 |
| 26 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.81609931 |
| 27 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.80545746 |
| 28 | * SPI1_23547873_ChIP-Seq_NB4_Human | 1.80544443 |
| 29 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.79875116 |
| 30 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.74987348 |
| 31 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.72424161 |
| 32 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.72155748 |
| 33 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.69713161 |
| 34 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.67117067 |
| 35 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.65092282 |
| 36 | MAF_26560356_Chip-Seq_TH1_Human | 1.64185467 |
| 37 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.63576826 |
| 38 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.60304064 |
| 39 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.59643563 |
| 40 | MYB_26560356_Chip-Seq_TH2_Human | 1.59220819 |
| 41 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.59120492 |
| 42 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.57242187 |
| 43 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.56579052 |
| 44 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.55295276 |
| 45 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.55151909 |
| 46 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.54521770 |
| 47 | * LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.53936958 |
| 48 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.52381124 |
| 49 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.50668767 |
| 50 | * LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.46784964 |
| 51 | SPI1_23127762_ChIP-Seq_K562_Human | 1.46315626 |
| 52 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.45744226 |
| 53 | * GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.45337337 |
| 54 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.42579830 |
| 55 | MYC_22102868_ChIP-Seq_BL_Human | 1.42432203 |
| 56 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.39359560 |
| 57 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.39094961 |
| 58 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.38896828 |
| 59 | MYB_26560356_Chip-Seq_TH1_Human | 1.38887489 |
| 60 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.36519811 |
| 61 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.36281452 |
| 62 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.36213587 |
| 63 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.34952073 |
| 64 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.32272061 |
| 65 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.30965006 |
| 66 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.29709932 |
| 67 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.29147666 |
| 68 | * GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.28903862 |
| 69 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.28684879 |
| 70 | UTX_26944678_Chip-Seq_JUKART_Human | 1.26795717 |
| 71 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.26279269 |
| 72 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.25220368 |
| 73 | * ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.22853189 |
| 74 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.22834642 |
| 75 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.22102625 |
| 76 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.22046419 |
| 77 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.21117168 |
| 78 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.19882938 |
| 79 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.19802097 |
| 80 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.17084327 |
| 81 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.16451492 |
| 82 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.16429263 |
| 83 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.16395512 |
| 84 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.15575908 |
| 85 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.15185170 |
| 86 | P68_20966046_ChIP-Seq_HELA_Human | 1.15182679 |
| 87 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.15051912 |
| 88 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.14787137 |
| 89 | GATA1_19941826_ChIP-Seq_K562_Human | 1.14409042 |
| 90 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.13887663 |
| 91 | * TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.12567652 |
| 92 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.12226645 |
| 93 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.11679513 |
| 94 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.11256155 |
| 95 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.10975004 |
| 96 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.10774747 |
| 97 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.10706047 |
| 98 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.10187329 |
| 99 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.09769262 |
| 100 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.09225854 |
| 101 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.08286348 |
| 102 | * SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.07859488 |
| 103 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.04954973 |
| 104 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.04584097 |
| 105 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.02089456 |
| 106 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.99659577 |
| 107 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.99534951 |
| 108 | * SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.99439726 |
| 109 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.99424459 |
| 110 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.99155210 |
| 111 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 0.98574087 |
| 112 | GATA3_26560356_Chip-Seq_TH2_Human | 0.97619726 |
| 113 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.97434662 |
| 114 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.95457326 |
| 115 | MAF_26560356_Chip-Seq_TH2_Human | 0.93276812 |
| 116 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.92805940 |
| 117 | GATA2_19941826_ChIP-Seq_K562_Human | 0.91186659 |
| 118 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.88891948 |
| 119 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.88327154 |
| 120 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.87456412 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005058_abnormal_lysosome_morphology | 3.71507388 |
| 2 | MP0001835_abnormal_antigen_presentation | 3.23198034 |
| 3 | MP0009785_altered_susceptibility_to | 2.69798364 |
| 4 | MP0000685_abnormal_immune_system | 2.42938762 |
| 5 | MP0003436_decreased_susceptibility_to | 2.39012775 |
| 6 | MP0003724_increased_susceptibility_to | 2.34938352 |
| 7 | MP0002148_abnormal_hypersensitivity_rea | 2.26847831 |
| 8 | MP0005671_abnormal_response_to | 2.25004969 |
| 9 | MP0002419_abnormal_innate_immunity | 2.23128464 |
| 10 | MP0005025_abnormal_response_to | 2.14308167 |
| 11 | MP0005387_immune_system_phenotype | 2.14279145 |
| 12 | MP0001790_abnormal_immune_system | 2.14279145 |
| 13 | MP0006054_spinal_hemorrhage | 2.13193759 |
| 14 | MP0006082_CNS_inflammation | 2.12409982 |
| 15 | MP0009840_abnormal_foam_cell | 2.10026540 |
| 16 | MP0005000_abnormal_immune_tolerance | 2.09633801 |
| 17 | MP0005451_abnormal_body_composition | 2.08145772 |
| 18 | MP0008260_abnormal_autophagy | 2.07130210 |
| 19 | MP0001800_abnormal_humoral_immune | 1.91737277 |
| 20 | MP0002166_altered_tumor_susceptibility | 1.90047448 |
| 21 | MP0002452_abnormal_antigen_presenting | 1.89464433 |
| 22 | MP0001873_stomach_inflammation | 1.87632538 |
| 23 | MP0002723_abnormal_immune_serum | 1.82605919 |
| 24 | MP0004947_skin_inflammation | 1.81195736 |
| 25 | MP0003191_abnormal_cellular_cholesterol | 1.80498247 |
| 26 | MP0005464_abnormal_platelet_physiology | 1.77421979 |
| 27 | MP0001533_abnormal_skeleton_physiology | 1.73813742 |
| 28 | MP0002405_respiratory_system_inflammati | 1.72519808 |
| 29 | MP0010155_abnormal_intestine_physiology | 1.70178755 |
| 30 | MP0002420_abnormal_adaptive_immunity | 1.69704171 |
| 31 | MP0003300_gastrointestinal_ulcer | 1.69531505 |
| 32 | MP0001845_abnormal_inflammatory_respons | 1.69225443 |
| 33 | MP0001819_abnormal_immune_cell | 1.68895682 |
| 34 | MP0008004_abnormal_stomach_pH | 1.67318780 |
| 35 | MP0003763_abnormal_thymus_physiology | 1.65554023 |
| 36 | MP0009278_abnormal_bone_marrow | 1.64731227 |
| 37 | MP0008438_abnormal_cutaneous_collagen | 1.59755619 |
| 38 | MP0005310_abnormal_salivary_gland | 1.56415699 |
| 39 | MP0001853_heart_inflammation | 1.55597460 |
| 40 | MP0002006_tumorigenesis | 1.52233462 |
| 41 | MP0008469_abnormal_protein_level | 1.48297732 |
| 42 | MP0003172_abnormal_lysosome_physiology | 1.47094124 |
| 43 | MP0001666_abnormal_nutrient_absorption | 1.43592634 |
| 44 | MP0005365_abnormal_bile_salt | 1.42036901 |
| 45 | MP0003186_abnormal_redox_activity | 1.40140107 |
| 46 | MP0003806_abnormal_nucleotide_metabolis | 1.38037939 |
| 47 | MP0003656_abnormal_erythrocyte_physiolo | 1.37075225 |
| 48 | MP0003183_abnormal_peptide_metabolism | 1.36256166 |
| 49 | MP0000858_altered_metastatic_potential | 1.34431042 |
| 50 | MP0009333_abnormal_splenocyte_physiolog | 1.32949431 |
| 51 | MP0005360_urolithiasis | 1.32605554 |
| 52 | MP0000716_abnormal_immune_system | 1.31864607 |
| 53 | MP0003453_abnormal_keratinocyte_physiol | 1.29177212 |
| 54 | MP0002396_abnormal_hematopoietic_system | 1.28322671 |
| 55 | MP0002933_joint_inflammation | 1.27727590 |
| 56 | MP0000465_gastrointestinal_hemorrhage | 1.27650601 |
| 57 | MP0002398_abnormal_bone_marrow | 1.27481425 |
| 58 | MP0009643_abnormal_urine_homeostasis | 1.26301577 |
| 59 | MP0000343_altered_response_to | 1.25836281 |
| 60 | MP0004510_myositis | 1.23781379 |
| 61 | MP0005083_abnormal_biliary_tract | 1.22879369 |
| 62 | MP0009764_decreased_sensitivity_to | 1.19398627 |
| 63 | MP0001851_eye_inflammation | 1.18978926 |
| 64 | MP0000689_abnormal_spleen_morphology | 1.16787954 |
| 65 | MP0002132_abnormal_respiratory_system | 1.13630825 |
| 66 | MP0002429_abnormal_blood_cell | 1.13188208 |
| 67 | MP0002998_abnormal_bone_remodeling | 1.12100800 |
| 68 | MP0002722_abnormal_immune_system | 1.10461686 |
| 69 | MP0003279_aneurysm | 1.09870999 |
| 70 | MP0005220_abnormal_exocrine_pancreas | 1.09686069 |
| 71 | MP0000490_abnormal_crypts_of | 1.09467909 |
| 72 | MP0002254_reproductive_system_inflammat | 1.09038012 |
| 73 | MP0003566_abnormal_cell_adhesion | 1.08483452 |
| 74 | MP0003866_abnormal_defecation | 1.08368728 |
| 75 | MP0002693_abnormal_pancreas_physiology | 1.08280648 |
| 76 | MP0004782_abnormal_surfactant_physiolog | 1.05448698 |
| 77 | MP0003075_altered_response_to | 1.04261486 |
| 78 | MP0010386_abnormal_urinary_bladder | 1.01824792 |
| 79 | MP0005165_increased_susceptibility_to | 1.00791409 |
| 80 | MP0003195_calcinosis | 1.00788518 |
| 81 | MP0000609_abnormal_liver_physiology | 0.99724839 |
| 82 | MP0005166_decreased_susceptibility_to | 0.98354568 |
| 83 | MP0005023_abnormal_wound_healing | 0.98014240 |
| 84 | MP0003329_amyloid_beta_deposits | 0.96951313 |
| 85 | MP0002877_abnormal_melanocyte_morpholog | 0.95626565 |
| 86 | MP0005164_abnormal_response_to | 0.94510771 |
| 87 | MP0003303_peritoneal_inflammation | 0.93329715 |
| 88 | MP0000003_abnormal_adipose_tissue | 0.92181350 |
| 89 | MP0003448_altered_tumor_morphology | 0.91665837 |
| 90 | MP0005319_abnormal_enzyme/_coenzyme | 0.90821070 |
| 91 | MP0005397_hematopoietic_system_phenotyp | 0.89869273 |
| 92 | MP0001545_abnormal_hematopoietic_system | 0.89869273 |
| 93 | MP0000249_abnormal_blood_vessel | 0.88054261 |
| 94 | MP0002136_abnormal_kidney_physiology | 0.87482683 |
| 95 | MP0003795_abnormal_bone_structure | 0.85024057 |
| 96 | MP0002138_abnormal_hepatobiliary_system | 0.84933715 |
| 97 | MP0005670_abnormal_white_adipose | 0.84472808 |
| 98 | MP0004808_abnormal_hematopoietic_stem | 0.83798825 |
| 99 | MP0003705_abnormal_hypodermis_morpholog | 0.82154383 |
| 100 | MP0000604_amyloidosis | 0.82019591 |
| 101 | MP0003091_abnormal_cell_migration | 0.81693595 |
| 102 | MP0002139_abnormal_hepatobiliary_system | 0.81660122 |
| 103 | MP0001764_abnormal_homeostasis | 0.80076840 |
| 104 | MP0005390_skeleton_phenotype | 0.80059817 |
| 105 | MP0001756_abnormal_urination | 0.80035673 |
| 106 | MP0004381_abnormal_hair_follicle | 0.79419798 |
| 107 | MP0000703_abnormal_thymus_morphology | 0.79263293 |
| 108 | MP0004264_abnormal_extraembryonic_tissu | 0.78917301 |
| 109 | MP0000013_abnormal_adipose_tissue | 0.78313304 |
| 110 | MP0003828_pulmonary_edema | 0.77049225 |
| 111 | MP0001849_ear_inflammation | 0.76721430 |
| 112 | MP0002060_abnormal_skin_morphology | 0.76654330 |
| 113 | MP0000598_abnormal_liver_morphology | 0.76241726 |
| 114 | MP0009763_increased_sensitivity_to | 0.76171214 |
| 115 | MP0001958_emphysema | 0.75512699 |
| 116 | MP0003045_fibrosis | 0.75502039 |
| 117 | MP0010329_abnormal_lipoprotein_level | 0.75229205 |
| 118 | MP0002118_abnormal_lipid_homeostasis | 0.74993225 |
| 119 | MP0004883_abnormal_blood_vessel | 0.74954636 |
| 120 | MP0001663_abnormal_digestive_system | 0.74929689 |
| 121 | MP0005167_abnormal_blood-brain_barrier | 0.71322497 |
| 122 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.71083321 |
| 123 | MP0008874_decreased_physiological_sensi | 0.70046027 |
| 124 | MP0003690_abnormal_glial_cell | 0.69434608 |
| 125 | MP0004858_abnormal_nervous_system | 0.67921862 |
| 126 | MP0001216_abnormal_epidermal_layer | 0.67160671 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Recurrent abscess formation (HP:0002722) | 4.54195168 |
| 2 | Vacuolated lymphocytes (HP:0001922) | 4.44370641 |
| 3 | Dysostosis multiplex (HP:0000943) | 4.37572037 |
| 4 | Recurrent bacterial skin infections (HP:0005406) | 4.12416081 |
| 5 | Eczematoid dermatitis (HP:0000976) | 3.95739637 |
| 6 | Urinary glycosaminoglycan excretion (HP:0003541) | 3.58660418 |
| 7 | Mucopolysacchariduria (HP:0008155) | 3.58660418 |
| 8 | Interstitial pulmonary disease (HP:0006530) | 3.51319009 |
| 9 | Increased cerebral lipofuscin (HP:0011813) | 3.41442837 |
| 10 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 3.36081960 |
| 11 | Systemic lupus erythematosus (HP:0002725) | 3.35114092 |
| 12 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 3.33107895 |
| 13 | Abnormality of polysaccharide metabolism (HP:0011012) | 3.33107895 |
| 14 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 3.33107895 |
| 15 | Petechiae (HP:0000967) | 3.18596584 |
| 16 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.03306460 |
| 17 | Abnormality of macrophages (HP:0004311) | 2.93364955 |
| 18 | Cellulitis (HP:0100658) | 2.91880008 |
| 19 | Amyloidosis (HP:0011034) | 2.91749586 |
| 20 | Optic neuritis (HP:0100653) | 2.89467930 |
| 21 | Retrobulbar optic neuritis (HP:0100654) | 2.89467930 |
| 22 | Stomatitis (HP:0010280) | 2.88157073 |
| 23 | Chronic otitis media (HP:0000389) | 2.87638553 |
| 24 | Prolonged bleeding time (HP:0003010) | 2.87056504 |
| 25 | Thrombocytosis (HP:0001894) | 2.87003402 |
| 26 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.80019570 |
| 27 | Recurrent viral infections (HP:0004429) | 2.75036114 |
| 28 | Chronic obstructive pulmonary disease (HP:0006510) | 2.71234836 |
| 29 | Obstructive lung disease (HP:0006536) | 2.71234836 |
| 30 | Myositis (HP:0100614) | 2.67275536 |
| 31 | Recurrent skin infections (HP:0001581) | 2.66204230 |
| 32 | Increased IgE level (HP:0003212) | 2.61631524 |
| 33 | Abnormality of glycolipid metabolism (HP:0010969) | 2.61504936 |
| 34 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.61504936 |
| 35 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.61504936 |
| 36 | Increased serum ferritin (HP:0003281) | 2.61157332 |
| 37 | Recurrent fungal infections (HP:0002841) | 2.60104705 |
| 38 | Asymmetric septal hypertrophy (HP:0001670) | 2.59465465 |
| 39 | Nasal polyposis (HP:0100582) | 2.56882615 |
| 40 | Generalized aminoaciduria (HP:0002909) | 2.53891504 |
| 41 | Abnormality of the nasal mucosa (HP:0000433) | 2.52644597 |
| 42 | Increased IgM level (HP:0003496) | 2.40555859 |
| 43 | Pustule (HP:0200039) | 2.37967909 |
| 44 | Autoimmune thrombocytopenia (HP:0001973) | 2.37147760 |
| 45 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 2.34505281 |
| 46 | Hypoglycemic coma (HP:0001325) | 2.34441896 |
| 47 | Recurrent bronchitis (HP:0002837) | 2.30614225 |
| 48 | Mediastinal lymphadenopathy (HP:0100721) | 2.29515108 |
| 49 | Vertebral compression fractures (HP:0002953) | 2.28669522 |
| 50 | Hypoplasia of the thymus (HP:0000778) | 2.26812351 |
| 51 | Abnormality of iron homeostasis (HP:0011031) | 2.25556835 |
| 52 | Beaking of vertebral bodies (HP:0004568) | 2.24907868 |
| 53 | Joint stiffness (HP:0001387) | 2.23898336 |
| 54 | Periodontitis (HP:0000704) | 2.18496778 |
| 55 | Progressive neurologic deterioration (HP:0002344) | 2.18346705 |
| 56 | Menorrhagia (HP:0000132) | 2.18032514 |
| 57 | Cholecystitis (HP:0001082) | 2.15784755 |
| 58 | Abnormal gallbladder physiology (HP:0012438) | 2.15784755 |
| 59 | Keratoconjunctivitis sicca (HP:0001097) | 2.15321733 |
| 60 | Colitis (HP:0002583) | 2.14345292 |
| 61 | Abnormal platelet volume (HP:0011876) | 2.13857220 |
| 62 | Axonal loss (HP:0003447) | 2.13828884 |
| 63 | Abnormality of T cell physiology (HP:0011840) | 2.09898497 |
| 64 | Ovoid vertebral bodies (HP:0003300) | 2.07704813 |
| 65 | Inflammation of the large intestine (HP:0002037) | 2.06952614 |
| 66 | Gastrointestinal inflammation (HP:0004386) | 2.06358778 |
| 67 | Gastrointestinal infarctions (HP:0005244) | 2.04469370 |
| 68 | Abnormality of the intrinsic pathway (HP:0010989) | 2.03894417 |
| 69 | IgM deficiency (HP:0002850) | 2.03766476 |
| 70 | Joint swelling (HP:0001386) | 2.03155414 |
| 71 | Malnutrition (HP:0004395) | 2.02222856 |
| 72 | Encephalitis (HP:0002383) | 2.02019182 |
| 73 | Gingivitis (HP:0000230) | 2.01987081 |
| 74 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.01441101 |
| 75 | Prolonged neonatal jaundice (HP:0006579) | 1.99489540 |
| 76 | Osteolytic defects of the hand bones (HP:0009699) | 1.98742195 |
| 77 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.98742195 |
| 78 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 1.98332027 |
| 79 | Cervical subluxation (HP:0003308) | 1.98175748 |
| 80 | Hemorrhage of the eye (HP:0011885) | 1.98133152 |
| 81 | Loss of speech (HP:0002371) | 1.97717647 |
| 82 | Osteomyelitis (HP:0002754) | 1.96007286 |
| 83 | Premature loss of primary teeth (HP:0006323) | 1.95930642 |
| 84 | Xanthomatosis (HP:0000991) | 1.95840024 |
| 85 | Tetraparesis (HP:0002273) | 1.95835238 |
| 86 | Orchitis (HP:0100796) | 1.95606002 |
| 87 | Keratoconjunctivitis (HP:0001096) | 1.95497995 |
| 88 | Agammaglobulinemia (HP:0004432) | 1.94859068 |
| 89 | Abnormal platelet function (HP:0011869) | 1.93392880 |
| 90 | Impaired platelet aggregation (HP:0003540) | 1.93392880 |
| 91 | Abnormality of T cell number (HP:0011839) | 1.93284062 |
| 92 | Abnormality of complement system (HP:0005339) | 1.90191454 |
| 93 | Glomerulonephritis (HP:0000099) | 1.90189201 |
| 94 | Mitral stenosis (HP:0001718) | 1.90088510 |
| 95 | Epistaxis (HP:0000421) | 1.88385186 |
| 96 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 1.87161178 |
| 97 | Panhypogammaglobulinemia (HP:0003139) | 1.86762051 |
| 98 | Purpura (HP:0000979) | 1.85958703 |
| 99 | Hypertriglyceridemia (HP:0002155) | 1.85780891 |
| 100 | Abnormality of T cells (HP:0002843) | 1.85480347 |
| 101 | Vasculitis (HP:0002633) | 1.85428778 |
| 102 | Neurofibrillary tangles (HP:0002185) | 1.84757444 |
| 103 | Meningitis (HP:0001287) | 1.84470952 |
| 104 | Autoimmune hemolytic anemia (HP:0001890) | 1.84201873 |
| 105 | Gingival bleeding (HP:0000225) | 1.82678888 |
| 106 | Myocardial infarction (HP:0001658) | 1.82172563 |
| 107 | Hemoptysis (HP:0002105) | 1.81483261 |
| 108 | Abnormality of the common coagulation pathway (HP:0010990) | 1.81118684 |
| 109 | Thoracic kyphosis (HP:0002942) | 1.81028122 |
| 110 | Basal ganglia calcification (HP:0002135) | 1.80996100 |
| 111 | Neuronal loss in central nervous system (HP:0002529) | 1.80829490 |
| 112 | Fatigue (HP:0012378) | 1.80496280 |
| 113 | T lymphocytopenia (HP:0005403) | 1.80250910 |
| 114 | Pulmonary infiltrates (HP:0002113) | 1.79769663 |
| 115 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.79562398 |
| 116 | Recurrent cutaneous fungal infections (HP:0011370) | 1.79562398 |
| 117 | Increased mean platelet volume (HP:0011877) | 1.79026470 |
| 118 | Urticaria (HP:0001025) | 1.78921307 |
| 119 | Nonimmune hydrops fetalis (HP:0001790) | 1.78334380 |
| 120 | J-shaped sella turcica (HP:0002680) | 1.78043095 |
| 121 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.77296985 |
| 122 | Deep venous thrombosis (HP:0002625) | 1.76856467 |
| 123 | Anorexia (HP:0002039) | 1.76752907 |
| 124 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 1.76646292 |
| 125 | Hepatosplenomegaly (HP:0001433) | 1.76478700 |
| 126 | Aortic aneurysm (HP:0004942) | 1.75604218 |
| 127 | Chronic diarrhea (HP:0002028) | 1.75244150 |
| 128 | Distal lower limb muscle weakness (HP:0009053) | 1.75053575 |
| 129 | Spondylolisthesis (HP:0003302) | 1.74653855 |
| 130 | Hypergammaglobulinemia (HP:0010702) | 1.73895739 |
| 131 | Poor head control (HP:0002421) | 1.73387439 |
| 132 | Gastrointestinal stroma tumor (HP:0100723) | 1.72598920 |
| 133 | Leukocytosis (HP:0001974) | 1.72216521 |
| 134 | Arterial thrombosis (HP:0004420) | 1.72075809 |
| 135 | Emphysema (HP:0002097) | 1.70223333 |
| 136 | Eosinophilia (HP:0001880) | 1.69064637 |
| 137 | Abnormal protein glycosylation (HP:0012346) | 1.68267300 |
| 138 | Abnormal glycosylation (HP:0012345) | 1.68267300 |
| 139 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.68267300 |
| 140 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.68267300 |
| 141 | Spontaneous hematomas (HP:0007420) | 1.67285915 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ERN1 | 4.02889243 |
| 2 | BCKDK | 3.47177235 |
| 3 | MAP4K1 | 2.96902909 |
| 4 | TYK2 | 2.79171148 |
| 5 | TESK2 | 2.77178315 |
| 6 | TBK1 | 2.61601950 |
| 7 | IRAK3 | 2.45573570 |
| 8 | JAK3 | 2.34128495 |
| 9 | PRPF4B | 2.21300377 |
| 10 | TAOK3 | 2.14592439 |
| 11 | ZAP70 | 2.11761264 |
| 12 | MAP3K14 | 2.11048024 |
| 13 | GRK6 | 2.10738556 |
| 14 | KIT | 2.10373275 |
| 15 | IKBKE | 2.02196917 |
| 16 | BLK | 1.93537891 |
| 17 | TGFBR2 | 1.91885359 |
| 18 | TRIB3 | 1.91452430 |
| 19 | JAK1 | 1.86940237 |
| 20 | ARAF | 1.84169613 |
| 21 | EPHB1 | 1.80591902 |
| 22 | FGFR4 | 1.80412246 |
| 23 | CSF1R | 1.78594844 |
| 24 | BTK | 1.76367626 |
| 25 | TAOK2 | 1.68146579 |
| 26 | FRK | 1.63720296 |
| 27 | IRAK4 | 1.61774360 |
| 28 | STK10 | 1.60178371 |
| 29 | SIK1 | 1.54762028 |
| 30 | PIM2 | 1.53845530 |
| 31 | TXK | 1.51482900 |
| 32 | FES | 1.43425288 |
| 33 | MAP2K3 | 1.43129913 |
| 34 | MAPK15 | 1.41849693 |
| 35 | NME2 | 1.36273070 |
| 36 | IKBKB | 1.36227195 |
| 37 | FLT3 | 1.36017672 |
| 38 | TEC | 1.33654731 |
| 39 | EPHA3 | 1.32041448 |
| 40 | TAOK1 | 1.30665925 |
| 41 | MAP3K13 | 1.29684663 |
| 42 | TNK2 | 1.27191159 |
| 43 | CSK | 1.25811252 |
| 44 | MYLK | 1.24353473 |
| 45 | SMG1 | 1.23863267 |
| 46 | LRRK2 | 1.20453504 |
| 47 | TTN | 1.16419553 |
| 48 | FGR | 1.14765250 |
| 49 | EPHA2 | 1.11306627 |
| 50 | PIK3CG | 1.11033419 |
| 51 | PTK6 | 1.09221983 |
| 52 | SYK | 1.08944869 |
| 53 | ITK | 1.08733460 |
| 54 | JAK2 | 1.06071303 |
| 55 | CDC42BPA | 1.05649299 |
| 56 | SIK3 | 1.03645639 |
| 57 | PRKD2 | 1.02719776 |
| 58 | KDR | 0.98536900 |
| 59 | MAP3K3 | 0.98094029 |
| 60 | RPS6KA4 | 0.97595041 |
| 61 | EIF2AK3 | 0.93652981 |
| 62 | NUAK1 | 0.92979205 |
| 63 | PKN2 | 0.92876479 |
| 64 | CHUK | 0.90369986 |
| 65 | NEK9 | 0.90317221 |
| 66 | MST4 | 0.87866656 |
| 67 | LCK | 0.86857308 |
| 68 | MET | 0.85015096 |
| 69 | NLK | 0.84038151 |
| 70 | PDPK1 | 0.82680973 |
| 71 | PASK | 0.81741723 |
| 72 | HIPK2 | 0.81603383 |
| 73 | PIK3CA | 0.78514343 |
| 74 | IRAK1 | 0.78194403 |
| 75 | TLK1 | 0.78155943 |
| 76 | INSRR | 0.77240779 |
| 77 | LYN | 0.76652915 |
| 78 | GRK7 | 0.76301108 |
| 79 | DDR2 | 0.75988649 |
| 80 | KSR2 | 0.75467005 |
| 81 | TESK1 | 0.73839504 |
| 82 | TRPM7 | 0.72562925 |
| 83 | LMTK2 | 0.71924320 |
| 84 | MAP2K2 | 0.71198716 |
| 85 | CLK1 | 0.69583034 |
| 86 | MOS | 0.68269076 |
| 87 | HCK | 0.67924900 |
| 88 | PDK1 | 0.66665801 |
| 89 | ABL2 | 0.66594529 |
| 90 | EEF2K | 0.66299614 |
| 91 | PAK4 | 0.65649550 |
| 92 | LIMK1 | 0.65403233 |
| 93 | CAMK1D | 0.64841123 |
| 94 | FGFR3 | 0.64452502 |
| 95 | BMX | 0.62495275 |
| 96 | PDGFRB | 0.59517421 |
| 97 | CAMKK2 | 0.57992857 |
| 98 | PIM1 | 0.57092934 |
| 99 | MAPKAPK3 | 0.57072674 |
| 100 | BMPR2 | 0.55923315 |
| 101 | PRKCD | 0.54133338 |
| 102 | PRKG2 | 0.53366918 |
| 103 | MAP3K1 | 0.51787658 |
| 104 | MAPK11 | 0.49717505 |
| 105 | RIPK1 | 0.49337314 |
| 106 | MATK | 0.49036859 |
| 107 | MAP3K11 | 0.48642106 |
| 108 | TIE1 | 0.46954653 |
| 109 | PTK2 | 0.46939909 |
| 110 | MAPKAPK2 | 0.45780000 |
| 111 | MAP2K6 | 0.45514992 |
| 112 | MAPK12 | 0.44886227 |
| 113 | RAF1 | 0.44059135 |
| 114 | SCYL2 | 0.43250604 |
| 115 | RPS6KA2 | 0.43169081 |
| 116 | RPS6KA6 | 0.43041049 |
| 117 | MARK2 | 0.42718928 |
| 118 | MAP3K6 | 0.41145853 |
| 119 | PTK2B | 0.41143841 |
| 120 | PDK2 | 0.40666072 |
| 121 | MARK3 | 0.40042361 |
| 122 | RPS6KB2 | 0.39243465 |
| 123 | MST1R | 0.38993101 |
| 124 | MAP3K5 | 0.38974898 |
| 125 | EIF2AK2 | 0.38126710 |
| 126 | MAP3K10 | 0.37910878 |
| 127 | FYN | 0.37901866 |
| 128 | IGF1R | 0.37875979 |
| 129 | PRKCH | 0.36804987 |
| 130 | TGFBR1 | 0.33785071 |
| 131 | DYRK1B | 0.33308384 |
| 132 | RIPK4 | 0.32386635 |
| 133 | LATS1 | 0.32294607 |
| 134 | MAPK3 | 0.31208573 |
| 135 | RPS6KC1 | 0.27958147 |
| 136 | RPS6KL1 | 0.27958147 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Other glycan degradation_Homo sapiens_hsa00511 | 3.01992520 |
| 2 | Protein export_Homo sapiens_hsa03060 | 2.63451396 |
| 3 | Lysosome_Homo sapiens_hsa04142 | 2.53851591 |
| 4 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 2.52020635 |
| 5 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 2.31044945 |
| 6 | Leishmaniasis_Homo sapiens_hsa05140 | 2.25747037 |
| 7 | Legionellosis_Homo sapiens_hsa05134 | 1.99830658 |
| 8 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.96727529 |
| 9 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.86909815 |
| 10 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.86826235 |
| 11 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.83872351 |
| 12 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.82464726 |
| 13 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.74318314 |
| 14 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.73512999 |
| 15 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.71925491 |
| 16 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.71244857 |
| 17 | Pertussis_Homo sapiens_hsa05133 | 1.67749978 |
| 18 | Malaria_Homo sapiens_hsa05144 | 1.65322071 |
| 19 | Measles_Homo sapiens_hsa05162 | 1.60481544 |
| 20 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.51182364 |
| 21 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.47447168 |
| 22 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.44930911 |
| 23 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.44766633 |
| 24 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.42809952 |
| 25 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.40769655 |
| 26 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.37723513 |
| 27 | Allograft rejection_Homo sapiens_hsa05330 | 1.36924749 |
| 28 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.35639589 |
| 29 | Galactose metabolism_Homo sapiens_hsa00052 | 1.30161913 |
| 30 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.27804916 |
| 31 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.27645283 |
| 32 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.26987968 |
| 33 | Influenza A_Homo sapiens_hsa05164 | 1.24801253 |
| 34 | Tuberculosis_Homo sapiens_hsa05152 | 1.24043748 |
| 35 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.15962044 |
| 36 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.14190327 |
| 37 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.10109672 |
| 38 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.08865945 |
| 39 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.08029412 |
| 40 | Renin-angiotensin system_Homo sapiens_hsa04614 | 1.06309580 |
| 41 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.06038895 |
| 42 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.04656870 |
| 43 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.02830701 |
| 44 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.00349556 |
| 45 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.99410791 |
| 46 | Apoptosis_Homo sapiens_hsa04210 | 0.99288754 |
| 47 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.98205044 |
| 48 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.97481816 |
| 49 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.96194815 |
| 50 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.94932197 |
| 51 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.94675341 |
| 52 | ABC transporters_Homo sapiens_hsa02010 | 0.93633794 |
| 53 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.93131980 |
| 54 | Salmonella infection_Homo sapiens_hsa05132 | 0.92952556 |
| 55 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.92929497 |
| 56 | Sulfur relay system_Homo sapiens_hsa04122 | 0.91183143 |
| 57 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.90749795 |
| 58 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.89951161 |
| 59 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.89389781 |
| 60 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.88525775 |
| 61 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.87307182 |
| 62 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.85160882 |
| 63 | Phagosome_Homo sapiens_hsa04145 | 0.84671015 |
| 64 | Peroxisome_Homo sapiens_hsa04146 | 0.84151071 |
| 65 | Endocytosis_Homo sapiens_hsa04144 | 0.83355570 |
| 66 | Amoebiasis_Homo sapiens_hsa05146 | 0.80877322 |
| 67 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.80698919 |
| 68 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.78781446 |
| 69 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.78066576 |
| 70 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.76464309 |
| 71 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.76168626 |
| 72 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.75508396 |
| 73 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.74400761 |
| 74 | Insulin resistance_Homo sapiens_hsa04931 | 0.73541946 |
| 75 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.72915139 |
| 76 | Hepatitis C_Homo sapiens_hsa05160 | 0.71961235 |
| 77 | Prion diseases_Homo sapiens_hsa05020 | 0.71750066 |
| 78 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.71442300 |
| 79 | Bladder cancer_Homo sapiens_hsa05219 | 0.70997794 |
| 80 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.67529916 |
| 81 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.67235191 |
| 82 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.67155905 |
| 83 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.67045105 |
| 84 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.66691393 |
| 85 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.65332982 |
| 86 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.63606656 |
| 87 | Shigellosis_Homo sapiens_hsa05131 | 0.63281917 |
| 88 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.63234155 |
| 89 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.63192416 |
| 90 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.61781396 |
| 91 | Hepatitis B_Homo sapiens_hsa05161 | 0.61745598 |
| 92 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.61560381 |
| 93 | Asthma_Homo sapiens_hsa05310 | 0.60986509 |
| 94 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.60601695 |
| 95 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.60570593 |
| 96 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.60160486 |
| 97 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.59026588 |
| 98 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.58354828 |
| 99 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.58148831 |
| 100 | Histidine metabolism_Homo sapiens_hsa00340 | 0.57927170 |
| 101 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.57197238 |
| 102 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.56128816 |
| 103 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.55742011 |
| 104 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.54852785 |
| 105 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.54648018 |
| 106 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.53711239 |
| 107 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.52668300 |
| 108 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.52225718 |
| 109 | Viral myocarditis_Homo sapiens_hsa05416 | 0.50629756 |
| 110 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.49238942 |
| 111 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.47973227 |
| 112 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.47598503 |
| 113 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.47300913 |
| 114 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.46661279 |
| 115 | Platelet activation_Homo sapiens_hsa04611 | 0.46225486 |
| 116 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.45866533 |
| 117 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.45359359 |
| 118 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.45238302 |
| 119 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.43432746 |
| 120 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.43240400 |
| 121 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.42485107 |
| 122 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.42204881 |
| 123 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.40323455 |
| 124 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.40047771 |
| 125 | HTLV-I infection_Homo sapiens_hsa05166 | 0.37955230 |
| 126 | Mineral absorption_Homo sapiens_hsa04978 | 0.35451340 |
| 127 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.33437712 |

