GPR119

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)9.87427617
2Golgi transport vesicle coating (GO:0048200)9.87427617
3signal peptide processing (GO:0006465)7.75508294
4positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003577.04061318
5endocrine pancreas development (GO:0031018)6.47210812
6positive regulation of insulin secretion (GO:0032024)6.24505637
7auditory receptor cell differentiation (GO:0042491)6.12745959
8retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.07084580
9peptide hormone processing (GO:0016486)5.95187308
10negative regulation of execution phase of apoptosis (GO:1900118)5.84658636
11regulation of extracellular matrix disassembly (GO:0010715)5.46654102
12glycerophospholipid catabolic process (GO:0046475)5.39874448
13glandular epithelial cell differentiation (GO:0002067)5.16686669
14maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.15245423
15positive regulation of peptide hormone secretion (GO:0090277)5.02157690
16COPII vesicle coating (GO:0048208)5.00267183
17inositol phosphate catabolic process (GO:0071545)4.92237647
18positive regulation of peptide secretion (GO:0002793)4.84275258
19inositol phosphate dephosphorylation (GO:0046855)4.77335586
20phosphorylated carbohydrate dephosphorylation (GO:0046838)4.77335586
21cellular ketone body metabolic process (GO:0046950)4.68171200
22regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)4.63895058
23positive regulation of vesicle fusion (GO:0031340)4.57383127
24protein retention in ER lumen (GO:0006621)4.55294214
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.52591513
26L-phenylalanine catabolic process (GO:0006559)4.52591513
27neuron fate specification (GO:0048665)4.50347955
28positive regulation of peptidyl-threonine phosphorylation (GO:0010800)4.42230774
29vesicle coating (GO:0006901)4.42179714
30regulation of insulin secretion (GO:0050796)4.39057886
31L-alpha-amino acid transmembrane transport (GO:1902475)4.38562304
32sequestering of metal ion (GO:0051238)4.38493667
33nitric oxide biosynthetic process (GO:0006809)4.37425270
34pyrimidine-containing compound salvage (GO:0008655)4.35819523
35pyrimidine nucleoside salvage (GO:0043097)4.35819523
36negative regulation of complement activation (GO:0045916)4.35598747
37regulation of type B pancreatic cell apoptotic process (GO:2000674)4.30624320
38cellular response to glucagon stimulus (GO:0071377)4.29622504
39epithelial cell fate commitment (GO:0072148)4.29537779
40cardiac left ventricle morphogenesis (GO:0003214)4.18430984
41ketone body metabolic process (GO:1902224)4.13757364
42negative regulation of JUN kinase activity (GO:0043508)4.09771671
43regulation of peptide hormone secretion (GO:0090276)4.01805698
44regulation of peptide secretion (GO:0002791)3.93927641
45regulation of execution phase of apoptosis (GO:1900117)3.92378294
46negative regulation of protein activation cascade (GO:2000258)3.91820118
47positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.90931357
48positive regulation of gluconeogenesis (GO:0045722)3.90639290
49negative regulation of digestive system process (GO:0060457)3.87007681
50response to dietary excess (GO:0002021)3.86258428
51erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.84494844
52L-phenylalanine metabolic process (GO:0006558)3.84494844
53positive regulation of hormone secretion (GO:0046887)3.83355052
54macroautophagy (GO:0016236)3.83313344
55glandular epithelial cell development (GO:0002068)3.81434991
56positive regulation of histone H3-K4 methylation (GO:0051571)3.80858987
57polyol catabolic process (GO:0046174)3.80087758
58type B pancreatic cell development (GO:0003323)3.78013413
59toxin metabolic process (GO:0009404)3.77125812
60positive regulation of calcium ion import (GO:0090280)3.74955440
61positive regulation of amino acid transport (GO:0051957)3.74840207
62astrocyte differentiation (GO:0048708)3.72943431
63retinol metabolic process (GO:0042572)3.71540125
64activation of protein kinase A activity (GO:0034199)3.66656769
65magnesium ion transport (GO:0015693)3.65692244
66respiratory chain complex IV assembly (GO:0008535)3.64081255
67cellular response to glucose starvation (GO:0042149)3.63699406
68* insulin secretion (GO:0030073)3.56480927
69regulation of glucokinase activity (GO:0033131)3.51050132
70regulation of hexokinase activity (GO:1903299)3.51050132
71regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.50240497
72regulation of hormone secretion (GO:0046883)3.49967773
73cytochrome complex assembly (GO:0017004)3.49951323
74pyrimidine nucleoside catabolic process (GO:0046135)3.47442445
75pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.40653269
76UMP metabolic process (GO:0046049)3.40653269
77pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.40653269
78UMP biosynthetic process (GO:0006222)3.40653269
79glycine transport (GO:0015816)3.36526181
80regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.31176099
81endocrine process (GO:0050886)3.31176099
82regulation of systemic arterial blood pressure by hormone (GO:0001990)3.31176099
83negative regulation of cytosolic calcium ion concentration (GO:0051481)3.30141041
84pteridine-containing compound biosynthetic process (GO:0042559)3.27196830
85negative regulation of humoral immune response (GO:0002921)3.25498860
86protein autoprocessing (GO:0016540)3.25138156
87response to glucagon (GO:0033762)3.24521188
88positive regulation of macroautophagy (GO:0016239)3.24424780
89detection of calcium ion (GO:0005513)3.24000651
90platelet dense granule organization (GO:0060155)3.22306182
91cytidine catabolic process (GO:0006216)3.21765855
92cytidine deamination (GO:0009972)3.21765855
93cytidine metabolic process (GO:0046087)3.21765855
94hair cell differentiation (GO:0035315)3.19745668
95cAMP biosynthetic process (GO:0006171)3.18343054
96positive regulation of response to extracellular stimulus (GO:0032106)3.18333970
97positive regulation of response to nutrient levels (GO:0032109)3.18333970
98sequestering of extracellular ligand from receptor (GO:0035581)3.18149850
99regulation of peptide transport (GO:0090087)3.16916920
100phenylpropanoid metabolic process (GO:0009698)3.15660369
101viral entry into host cell (GO:0046718)3.15626871
102inner ear receptor cell differentiation (GO:0060113)3.14892483
103regulation of calcium ion-dependent exocytosis (GO:0017158)3.14252504
104eating behavior (GO:0042755)3.11593651
105peptide metabolic process (GO:0006518)3.11374496
106nucleoside salvage (GO:0043174)3.11293662
107pyrimidine ribonucleoside catabolic process (GO:0046133)3.10065411
108cellular zinc ion homeostasis (GO:0006882)3.09210039
109regulation of protein glycosylation (GO:0060049)3.08884562
110mitotic cell cycle arrest (GO:0071850)3.08761897
111GDP-mannose metabolic process (GO:0019673)3.08689414
112response to pheromone (GO:0019236)3.05175723
113positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.03803129
114interleukin-1-mediated signaling pathway (GO:0070498)3.02963663
115exocrine pancreas development (GO:0031017)3.02359508
116pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.00729426
117zinc ion homeostasis (GO:0055069)2.99057098
118cellular response to vitamin D (GO:0071305)2.98811531
119nucleotide salvage (GO:0043173)2.98533931
120positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.98010545
121renal tubule morphogenesis (GO:0061333)2.97677769
122nitric oxide mediated signal transduction (GO:0007263)2.97569346
123negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.95531134
124positive regulation of gastrulation (GO:2000543)2.91312083
125negative regulation of cAMP-mediated signaling (GO:0043951)2.90682075
126activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.89471832
127columnar/cuboidal epithelial cell development (GO:0002066)2.89335860
128* peptide hormone secretion (GO:0030072)2.86994973
129pharyngeal system development (GO:0060037)2.86177424
130cerebellar Purkinje cell layer development (GO:0021680)2.85953893
131inositol phosphate-mediated signaling (GO:0048016)2.85599186
132regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.85088418
133C-terminal protein lipidation (GO:0006501)2.84668600
134nodal signaling pathway (GO:0038092)2.83956898
135regulation of glucocorticoid secretion (GO:2000849)2.83346915
136protein maturation by protein folding (GO:0022417)2.82404587
137primitive streak formation (GO:0090009)2.82172093
138vitamin D metabolic process (GO:0042359)2.80494619
139response to hepatocyte growth factor (GO:0035728)2.79961186
140cellular response to hepatocyte growth factor stimulus (GO:0035729)2.79961186
141negative regulation of glycoprotein biosynthetic process (GO:0010561)2.79907745
142protein complex biogenesis (GO:0070271)2.79533246
143* peptide secretion (GO:0002790)2.79525324
144adult feeding behavior (GO:0008343)2.76994155
145aromatic amino acid family catabolic process (GO:0009074)2.75418360
146dopamine biosynthetic process (GO:0042416)2.69599488
147artery smooth muscle contraction (GO:0014824)2.69228152
148regulation of fibrinolysis (GO:0051917)2.67995249
149intra-Golgi vesicle-mediated transport (GO:0006891)2.64549613
150basic amino acid transport (GO:0015802)2.63626937
151phospholipid catabolic process (GO:0009395)2.63276515
152regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.59098970
153regulation of Rac protein signal transduction (GO:0035020)2.57128711
154snRNA transcription (GO:0009301)2.56524817
155regulation of acrosome reaction (GO:0060046)2.55982984
156dopamine transport (GO:0015872)2.53771327
157nephron tubule morphogenesis (GO:0072078)2.53336917
158nephron epithelium morphogenesis (GO:0072088)2.53336917
159neuromuscular process controlling posture (GO:0050884)2.51959785
160regulation of calcium ion import (GO:0090279)2.51547533
161endosome to melanosome transport (GO:0035646)2.50882389
162endosome to pigment granule transport (GO:0043485)2.50882389
163C-terminal protein amino acid modification (GO:0018410)2.44788344
164* peptide transport (GO:0015833)2.44309235
165nitric oxide metabolic process (GO:0046209)2.43866846
166mitochondrial respiratory chain complex assembly (GO:0033108)2.43337682
167regulation of acyl-CoA biosynthetic process (GO:0050812)2.42318896

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.97720679
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.08508675
3PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.75004734
4ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.26545128
5GBX2_23144817_ChIP-Seq_PC3_Human3.17634771
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.64993528
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.64829029
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36747834
9DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.33439575
10* OLIG2_26023283_ChIP-Seq_AINV15_Mouse2.21087357
11HTT_18923047_ChIP-ChIP_STHdh_Human2.20957575
12IGF1R_20145208_ChIP-Seq_DFB_Human2.20141611
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.13865410
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.13663228
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.00648255
16NR3C1_23031785_ChIP-Seq_PC12_Mouse1.98807835
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.95759169
18GATA1_22025678_ChIP-Seq_K562_Human1.88229186
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79577183
20ZNF274_21170338_ChIP-Seq_K562_Hela1.78094814
21FUS_26573619_Chip-Seq_HEK293_Human1.77953464
22NFIB_24661679_ChIP-Seq_LUNG_Mouse1.76481910
23LXR_22158963_ChIP-Seq_LIVER_Mouse1.70920285
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70569840
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68990314
26SMAD4_21799915_ChIP-Seq_A2780_Human1.67931788
27SOX2_27498859_Chip-Seq_STOMACH_Mouse1.66723458
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64878137
29FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.63974567
30FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.63623826
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.63146337
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62017653
33RXR_22158963_ChIP-Seq_LIVER_Mouse1.60311603
34FOXA1_25552417_ChIP-Seq_VCAP_Human1.56523086
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.56252578
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54135385
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.50443146
38VDR_22108803_ChIP-Seq_LS180_Human1.48620360
39FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.47912399
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.47389920
41NANOG_18555785_Chip-Seq_ESCs_Mouse1.46743475
42ER_23166858_ChIP-Seq_MCF-7_Human1.46158431
43SOX2_18555785_Chip-Seq_ESCs_Mouse1.44460881
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.43954176
45P300_19829295_ChIP-Seq_ESCs_Human1.43953508
46REST_21632747_ChIP-Seq_MESCs_Mouse1.43704932
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.42863152
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42484406
49EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42319197
50AR_25329375_ChIP-Seq_VCAP_Human1.40732292
51SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.39022680
52TAF15_26573619_Chip-Seq_HEK293_Human1.38442241
53EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.37768400
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.37614141
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37165157
56TP53_22573176_ChIP-Seq_HFKS_Human1.36746662
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36517828
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36355976
59P53_22387025_ChIP-Seq_ESCs_Mouse1.34940307
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34468996
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33789005
62STAT3_18555785_Chip-Seq_ESCs_Mouse1.33323237
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.31424584
64SUZ12_18555785_Chip-Seq_ESCs_Mouse1.31347395
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30837013
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.30323688
67CMYC_18555785_Chip-Seq_ESCs_Mouse1.28038279
68E2F1_18555785_Chip-Seq_ESCs_Mouse1.27705751
69SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27362965
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26400859
71REST_19997604_ChIP-ChIP_NEURONS_Mouse1.25933396
72NMYC_18555785_Chip-Seq_ESCs_Mouse1.24508337
73FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24423515
74FOXA1_25329375_ChIP-Seq_VCAP_Human1.24097092
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24097092
76SOX2_20726797_ChIP-Seq_SW620_Human1.24019696
77CTCF_18555785_Chip-Seq_ESCs_Mouse1.22193822
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20271098
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19815021
80CDX2_22108803_ChIP-Seq_LS180_Human1.19337393
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18074751
82P300_18555785_Chip-Seq_ESCs_Mouse1.17452716
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.17337960
84EZH2_27294783_Chip-Seq_ESCs_Mouse1.16623420
85FOXH1_21741376_ChIP-Seq_ESCs_Human1.14712736
86BCAT_22108803_ChIP-Seq_LS180_Human1.14488262
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14379060
88TAL1_26923725_Chip-Seq_HPCs_Mouse1.13812400
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13515218
90NANOG_19829295_ChIP-Seq_ESCs_Human1.13500476
91SOX2_19829295_ChIP-Seq_ESCs_Human1.13500476
92HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11460068
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10511606
94SMAD1_18555785_Chip-Seq_ESCs_Mouse1.09561163
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.08934255
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08913675
97PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08773228
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.08251778
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07782628
100STAT3_23295773_ChIP-Seq_U87_Human1.07584471
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07424692
102ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06584472
103KLF4_18555785_Chip-Seq_ESCs_Mouse1.06211642
104TCF4_22108803_ChIP-Seq_LS180_Human1.05480549
105RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05473580
106EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05091605
107* AR_20517297_ChIP-Seq_VCAP_Human1.05019640
108CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04240456
109SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03115071
110PU1_27457419_Chip-Seq_LIVER_Mouse1.03091669
111ZFX_18555785_Chip-Seq_ESCs_Mouse1.00924231
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00219273
113NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00119734
114CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99505974
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99366141
116NCOR_22424771_ChIP-Seq_293T_Human0.99343134
117* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98569962
118TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98210680
119CRX_20693478_ChIP-Seq_RETINA_Mouse0.97876675
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96715924
121CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95956166
122PHF8_20622853_ChIP-Seq_HELA_Human0.95734925
123CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95577069
124RUNX1_26923725_Chip-Seq_HPCs_Mouse0.95391878
125STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95163601
126GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.95093212
127GATA1_19941826_ChIP-Seq_K562_Human0.94870293
128EWS_26573619_Chip-Seq_HEK293_Human0.94773683
129IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94293675
130CBP_20019798_ChIP-Seq_JUKART_Human0.94293675
131HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93834053
132NFYB_21822215_ChIP-Seq_K562_Human0.93088883
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93040312
134BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92819050
135PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91802319
136ESR2_21235772_ChIP-Seq_MCF-7_Human0.91606496
137HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91356620
138ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91243673
139DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88650994
140PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88267294
141AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88158824
142DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87459032
143POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86624018
144DROSHA_22980978_ChIP-Seq_HELA_Human0.86537186
145PPARA_22158963_ChIP-Seq_LIVER_Mouse0.85720531
146SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.84839722
147P53_21459846_ChIP-Seq_SAOS-2_Human0.84692240
148GATA3_24758297_ChIP-Seq_MCF-7_Human0.83435201
149PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82148982
150SUZ12_27294783_Chip-Seq_ESCs_Mouse0.82142419
151PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.81782451
152PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81679960
153SOX17_20123909_ChIP-Seq_XEN_Mouse0.81090276
154FOXA2_19822575_ChIP-Seq_HepG2_Human0.81087789
155MTF2_20144788_ChIP-Seq_MESCs_Mouse0.80418066
156STAT1_20625510_ChIP-Seq_HELA_Human0.80043346
157JARID2_20075857_ChIP-Seq_MESCs_Mouse0.79846254
158SMAD3_21741376_ChIP-Seq_ESCs_Human0.79767983
159EZH2_27304074_Chip-Seq_ESCs_Mouse0.79729776
160SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.78566379
161ZFX_18555785_ChIP-Seq_MESCs_Mouse0.78326077
162ERG_21242973_ChIP-ChIP_JURKAT_Human0.78284173
163RUNX2_22187159_ChIP-Seq_PCA_Human0.78129099
164TCF4_23295773_ChIP-Seq_U87_Human0.78118111
165MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.75056485
166* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.74673550
167SOX2_21211035_ChIP-Seq_LN229_Gbm0.74462029
168YAP1_20516196_ChIP-Seq_MESCs_Mouse0.74233639
169* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73835655
170GATA3_27048872_Chip-Seq_THYMUS_Human0.73008107
171KLF4_19829295_ChIP-Seq_ESCs_Human0.72783351
172EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.72049183
173VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.71561578

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue6.02849332
2MP0002837_dystrophic_cardiac_calcinosis4.59772664
3MP0003183_abnormal_peptide_metabolism4.42081098
4MP0003195_calcinosis4.16882914
5MP0000003_abnormal_adipose_tissue3.57216214
6MP0010386_abnormal_urinary_bladder3.50289767
7MP0005379_endocrine/exocrine_gland_phen3.49419884
8MP0003806_abnormal_nucleotide_metabolis3.46549967
9MP0005645_abnormal_hypothalamus_physiol3.35526284
10MP0001944_abnormal_pancreas_morphology3.26104646
11MP0003283_abnormal_digestive_organ3.19589042
12MP0002877_abnormal_melanocyte_morpholog3.17136643
13MP0002909_abnormal_adrenal_gland3.13534794
14MP0002254_reproductive_system_inflammat3.08432831
15MP0002693_abnormal_pancreas_physiology3.05313016
16MP0005409_darkened_coat_color2.94187936
17MP0004043_abnormal_pH_regulation2.88059017
18MP0005220_abnormal_exocrine_pancreas2.69191665
19MP0006072_abnormal_retinal_apoptosis2.42175591
20MP0003122_maternal_imprinting2.34033412
21MP0000372_irregular_coat_pigmentation2.29449272
22MP0000678_abnormal_parathyroid_gland2.24315396
23MP0003011_delayed_dark_adaptation2.17751762
24MP0009780_abnormal_chondrocyte_physiolo2.13743247
25MP0001756_abnormal_urination2.13274211
26MP0005174_abnormal_tail_pigmentation2.08249992
27MP0002138_abnormal_hepatobiliary_system1.99686090
28MP0002078_abnormal_glucose_homeostasis1.94689537
29MP0004270_analgesia1.93727370
30MP0008961_abnormal_basal_metabolism1.92290785
31MP0010329_abnormal_lipoprotein_level1.90475632
32MP0005084_abnormal_gallbladder_morpholo1.79395420
33MP0005365_abnormal_bile_salt1.67589382
34MP0003787_abnormal_imprinting1.66122462
35MP0009046_muscle_twitch1.60793677
36MP0002638_abnormal_pupillary_reflex1.59998979
37MP0002163_abnormal_gland_morphology1.53260193
38MP0005375_adipose_tissue_phenotype1.51471812
39MP0003959_abnormal_lean_body1.51083711
40MP0001765_abnormal_ion_homeostasis1.42238341
41MP0001502_abnormal_circadian_rhythm1.41496877
42MP0004147_increased_porphyrin_level1.39158050
43MP0004264_abnormal_extraembryonic_tissu1.34893947
44MP0009643_abnormal_urine_homeostasis1.31067104
45MP0010234_abnormal_vibrissa_follicle1.31014941
46MP0000427_abnormal_hair_cycle1.30840118
47MP0003172_abnormal_lysosome_physiology1.29917831
48MP0005408_hypopigmentation1.22498876
49MP0001501_abnormal_sleep_pattern1.22403810
50MP0003953_abnormal_hormone_level1.20301059
51MP0005248_abnormal_Harderian_gland1.18654238
52MP0002751_abnormal_autonomic_nervous1.16591829
53MP0003121_genomic_imprinting1.15317317
54MP0005551_abnormal_eye_electrophysiolog1.12440406
55MP0002064_seizures1.07854891
56MP0002938_white_spotting1.05983539
57MP0005636_abnormal_mineral_homeostasis1.05410237
58MP0001186_pigmentation_phenotype1.04336703
59MP0002139_abnormal_hepatobiliary_system1.03917816
60MP0009745_abnormal_behavioral_response1.03544561
61MP0000631_abnormal_neuroendocrine_gland1.02886095
62MP0005257_abnormal_intraocular_pressure1.02829076
63MP0005085_abnormal_gallbladder_physiolo1.02458611
64MP0003123_paternal_imprinting1.02030857
65MP0001986_abnormal_taste_sensitivity1.01772303
66MP0002734_abnormal_mechanical_nocicepti1.00086547
67MP0002184_abnormal_innervation0.99139173
68MP0003300_gastrointestinal_ulcer0.98178820
69MP0000015_abnormal_ear_pigmentation0.95475130
70MP0003868_abnormal_feces_composition0.95175303
71MP0002928_abnormal_bile_duct0.94625997
72MP0002733_abnormal_thermal_nociception0.94282069
73MP0000230_abnormal_systemic_arterial0.92752817
74MP0004133_heterotaxia0.89632033
75MP0000613_abnormal_salivary_gland0.87339135
76MP0004019_abnormal_vitamin_homeostasis0.85656121
77MP0001905_abnormal_dopamine_level0.85095005
78MP0004215_abnormal_myocardial_fiber0.85016313
79MP0005448_abnormal_energy_balance0.84756650
80MP0002557_abnormal_social/conspecific_i0.84614804
81MP0003252_abnormal_bile_duct0.84327282
82MP0000538_abnormal_urinary_bladder0.82806586
83MP0000462_abnormal_digestive_system0.82496895
84MP0002896_abnormal_bone_mineralization0.82083767
85MP0003879_abnormal_hair_cell0.81163582
86MP0003119_abnormal_digestive_system0.80299366
87MP0004085_abnormal_heartbeat0.79921333
88MP0004885_abnormal_endolymph0.79624288
89MP0005452_abnormal_adipose_tissue0.78349683
90MP0002272_abnormal_nervous_system0.77230451
91MP0001348_abnormal_lacrimal_gland0.75513951
92MP0002295_abnormal_pulmonary_circulatio0.74562871
93MP0004233_abnormal_muscle_weight0.73632624
94MP0003890_abnormal_embryonic-extraembry0.73465814
95MP0005334_abnormal_fat_pad0.70815887
96MP0003633_abnormal_nervous_system0.70312567
97MP0002229_neurodegeneration0.70256120
98MP0000516_abnormal_urinary_system0.69838622
99MP0005367_renal/urinary_system_phenotyp0.69838622
100MP0001529_abnormal_vocalization0.69720660
101MP0001984_abnormal_olfaction0.69541597
102MP0002069_abnormal_eating/drinking_beha0.67619741
103MP0004145_abnormal_muscle_electrophysio0.67101241
104MP0005646_abnormal_pituitary_gland0.67063849
105MP0008057_abnormal_DNA_replication0.66921295
106MP0001299_abnormal_eye_distance/0.66878357
107MP0005253_abnormal_eye_physiology0.65965298
108MP0005535_abnormal_body_temperature0.64752648
109MP0005332_abnormal_amino_acid0.64460745
110MP0001764_abnormal_homeostasis0.63575280
111MP0008875_abnormal_xenobiotic_pharmacok0.63359189
112MP0002075_abnormal_coat/hair_pigmentati0.62186068
113MP0001661_extended_life_span0.62068187
114MP0000639_abnormal_adrenal_gland0.61855226
115MP0005389_reproductive_system_phenotype0.61220156
116MP0006292_abnormal_olfactory_placode0.61163077
117MP0001970_abnormal_pain_threshold0.61131301
118MP0002572_abnormal_emotion/affect_behav0.60800857
119MP0008775_abnormal_heart_ventricle0.60562825
120MP0001666_abnormal_nutrient_absorption0.60529263
121MP0008877_abnormal_DNA_methylation0.60043910
122MP0001664_abnormal_digestion0.59562381
123MP0002876_abnormal_thyroid_physiology0.59412760
124MP0005058_abnormal_lysosome_morphology0.59144790
125MP0002118_abnormal_lipid_homeostasis0.59021496
126MP0005423_abnormal_somatic_nervous0.58765265
127MP0002127_abnormal_cardiovascular_syste0.58289574
128MP0006036_abnormal_mitochondrial_physio0.57777728
129MP0001270_distended_abdomen0.57725892
130MP0002166_altered_tumor_susceptibility0.56974553
131MP0005075_abnormal_melanosome_morpholog0.56093330
132MP0003786_premature_aging0.54683458
133MP0001919_abnormal_reproductive_system0.54332121
134MP0000955_abnormal_spinal_cord0.53966080
135MP0002971_abnormal_brown_adipose0.53947678
136MP0006054_spinal_hemorrhage0.53235332
137MP0000371_diluted_coat_color0.53225622
138MP0002177_abnormal_outer_ear0.52908257
139MP0009642_abnormal_blood_homeostasis0.48209302
140MP0002970_abnormal_white_adipose0.48050896
141MP0002234_abnormal_pharynx_morphology0.46566993

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)7.02377184
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.35630966
3Hypoglycemic seizures (HP:0002173)6.06899655
4Hyperglycemia (HP:0003074)5.59611067
5Ketoacidosis (HP:0001993)5.57894755
6Hypoglycemic coma (HP:0001325)5.57134623
7Symptomatic seizures (HP:0011145)5.03818200
8Abnormality of calcium-phosphate metabolism (HP:0100530)5.00151501
9Abnormality of aromatic amino acid family metabolism (HP:0004338)4.78707175
10Abnormality of the pancreatic islet cells (HP:0006476)4.53150320
11Abnormality of endocrine pancreas physiology (HP:0012093)4.53150320
12Pancreatic islet-cell hyperplasia (HP:0004510)4.44423228
13Sensory axonal neuropathy (HP:0003390)4.24193545
14Intestinal atresia (HP:0011100)4.23687978
15Papillary thyroid carcinoma (HP:0002895)4.21553971
16Late onset (HP:0003584)4.18463365
17Insulin-resistant diabetes mellitus (HP:0000831)4.12320410
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.05083581
19Dysautonomia (HP:0002459)3.77495414
20Retinal atrophy (HP:0001105)3.65697951
21Microvesicular hepatic steatosis (HP:0001414)3.60885342
22Limb hypertonia (HP:0002509)3.51042183
23Cortical visual impairment (HP:0100704)3.49501641
24Hypothermia (HP:0002045)3.48426832
25Large for gestational age (HP:0001520)3.47889293
26Orthostatic hypotension (HP:0001278)3.45557775
27Urinary glycosaminoglycan excretion (HP:0003541)3.45273289
28Mucopolysacchariduria (HP:0008155)3.45273289
29Abnormal pancreas size (HP:0012094)3.34349473
30Ketosis (HP:0001946)3.32728106
31Agitation (HP:0000713)3.31592287
32Testicular atrophy (HP:0000029)3.28827607
33Dysostosis multiplex (HP:0000943)3.11055254
34Increased CSF protein (HP:0002922)3.06272077
35Abnormality of polysaccharide metabolism (HP:0011012)3.05485449
36Abnormality of glycosaminoglycan metabolism (HP:0004371)3.05485449
37Abnormality of mucopolysaccharide metabolism (HP:0011020)3.05485449
38Vascular calcification (HP:0004934)3.02327063
39Decreased circulating renin level (HP:0003351)2.99606827
40Progressive macrocephaly (HP:0004481)2.97329625
41Acute necrotizing encephalopathy (HP:0006965)2.93658982
42Postural tremor (HP:0002174)2.92054066
43Congenital malformation of the right heart (HP:0011723)2.88146510
44Double outlet right ventricle (HP:0001719)2.88146510
45Abnormality of vitamin metabolism (HP:0100508)2.87452404
46Hyperparathyroidism (HP:0000843)2.82879996
47Insulin resistance (HP:0000855)2.71045366
48Proximal tubulopathy (HP:0000114)2.70041867
49Prominent metopic ridge (HP:0005487)2.68436856
503-Methylglutaconic aciduria (HP:0003535)2.68150835
51Congenital sensorineural hearing impairment (HP:0008527)2.67030490
52Cardiovascular calcification (HP:0011915)2.59994214
53Progressive muscle weakness (HP:0003323)2.59809918
54Arthropathy (HP:0003040)2.59460089
55Hypokalemia (HP:0002900)2.56344243
56Cardiomegaly (HP:0001640)2.56207944
57EEG with generalized epileptiform discharges (HP:0011198)2.55856140
58Acute encephalopathy (HP:0006846)2.54233126
59Abnormality of liposaccharide metabolism (HP:0010968)2.51216821
60Abnormality of glycosphingolipid metabolism (HP:0004343)2.51216821
61Abnormality of glycolipid metabolism (HP:0010969)2.51216821
62Hypsarrhythmia (HP:0002521)2.50300001
63Methylmalonic acidemia (HP:0002912)2.46760528
64Abnormal sex determination (HP:0012244)2.46148118
65Sex reversal (HP:0012245)2.46148118
66Epileptiform EEG discharges (HP:0011182)2.44930196
67Abnormality of the renal cortex (HP:0011035)2.43473997
68Abnormal mitochondria in muscle tissue (HP:0008316)2.40522065
69Progressive neurologic deterioration (HP:0002344)2.39015557
70Hypotension (HP:0002615)2.37864926
71Thyroid carcinoma (HP:0002890)2.37424948
72Abnormality of renin-angiotensin system (HP:0000847)2.35078555
73Methylmalonic aciduria (HP:0012120)2.29748914
74Renal cortical cysts (HP:0000803)2.29717231
75Enlarged penis (HP:0000040)2.29172888
76Abnormality of potassium homeostasis (HP:0011042)2.27440991
77Abnormality of the metopic suture (HP:0005556)2.26406412
78Xanthomatosis (HP:0000991)2.26212398
79Episodic fever (HP:0001954)2.25593791
80Mitochondrial inheritance (HP:0001427)2.24836635
81Conjunctival hamartoma (HP:0100780)2.24775105
82Tachypnea (HP:0002789)2.24557913
83Furrowed tongue (HP:0000221)2.24309373
84Osteomalacia (HP:0002749)2.24238648
85Unilateral renal agenesis (HP:0000122)2.23682358
86Vacuolated lymphocytes (HP:0001922)2.23421768
87Generalized aminoaciduria (HP:0002909)2.23257589
88Long toe (HP:0010511)2.22273771
89Pancreatic fibrosis (HP:0100732)2.22123137
90Abdominal distention (HP:0003270)2.21981541
91Absent rod-and cone-mediated responses on ERG (HP:0007688)2.20455927
92Congenital stationary night blindness (HP:0007642)2.20002027
93Anxiety (HP:0000739)2.19616519
94Molar tooth sign on MRI (HP:0002419)2.18646708
95Abnormality of midbrain morphology (HP:0002418)2.18646708
96Limb dystonia (HP:0002451)2.18572583
97Testicular neoplasm (HP:0010788)2.18335082
98Increased circulating renin level (HP:0000848)2.18030632
99Palpitations (HP:0001962)2.17883134
100Zonular cataract (HP:0010920)2.16740758
101Hyperkalemia (HP:0002153)2.15636628
102Metaphyseal dysplasia (HP:0100255)2.14811216
103Generalized hyperpigmentation (HP:0007440)2.14554245
104Overlapping toe (HP:0001845)2.13075093
105Abnormal biliary tract morphology (HP:0012440)2.12766474
106Neoplasm of the thyroid gland (HP:0100031)2.12223394
107Hyperthyroidism (HP:0000836)2.12074723
108Menstrual irregularities (HP:0000858)2.10923180
109Glycosuria (HP:0003076)2.10888488
110Abnormality of urine glucose concentration (HP:0011016)2.10888488
111Hypoalbuminemia (HP:0003073)2.10515260
112Abnormal albumin level (HP:0012116)2.10515260
113Gout (HP:0001997)2.08956541
114Abnormal autonomic nervous system physiology (HP:0012332)2.08451802
115Macroorchidism (HP:0000053)2.07923227
116Resting tremor (HP:0002322)2.07165567
117Pheochromocytoma (HP:0002666)2.06521654
118Micronodular cirrhosis (HP:0001413)2.05842904
119Hyperphosphatemia (HP:0002905)2.04336372
120True hermaphroditism (HP:0010459)2.04045421
121Nephronophthisis (HP:0000090)2.02597474
122Abnormality of chloride homeostasis (HP:0011422)2.01989494
123Mildly elevated creatine phosphokinase (HP:0008180)2.01652348
124Dicarboxylic aciduria (HP:0003215)2.01281833
125Abnormality of dicarboxylic acid metabolism (HP:0010995)2.01281833
126Abnormality of the fovea (HP:0000493)2.01117218
127Aplasia/Hypoplasia of the fovea (HP:0008060)2.00779255
128Hypoplasia of the fovea (HP:0007750)2.00779255
129Restlessness (HP:0000711)1.99218773
130Medial flaring of the eyebrow (HP:0010747)1.98329339
131Chronic diarrhea (HP:0002028)1.97831245
132Nuclear cataract (HP:0100018)1.96918688
133Increased CSF lactate (HP:0002490)1.94732312
134Gastrointestinal atresia (HP:0002589)1.94703459
135Muscular hypotonia of the trunk (HP:0008936)1.93542705
136Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.93529842
137Large eyes (HP:0001090)1.91740768
138Abnormal rod and cone electroretinograms (HP:0008323)1.91500722
139Congenital glaucoma (HP:0001087)1.91313111
140Poor suck (HP:0002033)1.91221386
141Prominent supraorbital ridges (HP:0000336)1.90763666
142Pancreatic cysts (HP:0001737)1.90652046
143Hypophosphatemia (HP:0002148)1.90613636
144Decreased activity of mitochondrial respiratory chain (HP:0008972)1.90506211
145Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.90506211
146Conjugated hyperbilirubinemia (HP:0002908)1.89509359
147Mesangial abnormality (HP:0001966)1.89115711
148Abnormality of the vitreous humor (HP:0004327)1.88666683
149Albinism (HP:0001022)1.88013517
150Polyphagia (HP:0002591)1.87750949
151Atelectasis (HP:0100750)1.87530698
152Protuberant abdomen (HP:0001538)1.86631952
153Papilledema (HP:0001085)1.86615744
154Cerebral edema (HP:0002181)1.86381907
155Hepatoblastoma (HP:0002884)1.83193276
156Malnutrition (HP:0004395)1.81189338
157Thoracolumbar scoliosis (HP:0002944)1.80646191
158Hyperphosphaturia (HP:0003109)1.79736539
159Abnormality of dental color (HP:0011073)1.79451237
160Disproportionate short-trunk short stature (HP:0003521)1.78018790
161Hemiparesis (HP:0001269)1.77634558
162Hypercortisolism (HP:0001578)1.77230981
163Neuroendocrine neoplasm (HP:0100634)1.77156841
164Abnormality of vitamin B metabolism (HP:0004340)1.76569756
165Exocrine pancreatic insufficiency (HP:0001738)1.76281105
166Irritability (HP:0000737)1.73887200

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK38.00690899
2MAPK156.44686461
3FRK4.60327645
4INSRR4.04030077
5PASK3.43613424
6PIK3CG3.43051267
7WNK43.31082992
8GRK12.96130105
9HIPK22.79538962
10PHKG12.63606966
11PHKG22.63606966
12ACVR1B2.63492495
13MAP4K22.57092560
14MAP3K122.54948056
15ARAF2.49561370
16DAPK22.49054811
17MAP2K62.11527508
18EPHA32.08944678
19MAP3K92.06518456
20UHMK11.94683703
21MAP3K131.92380697
22FGFR21.86247272
23MAP3K21.84613662
24STK31.84552729
25MST41.83347694
26STK161.82978784
27PRKD31.81020179
28KSR21.67993499
29TRPM71.60555598
30MAPK131.55120596
31CASK1.43924213
32MAP3K11.32694564
33TRIM281.32656133
34TNK21.30291453
35YES11.28261798
36WNK11.25260487
37TAOK31.23314976
38STK41.20741402
39BRAF1.19993759
40CSNK1G11.15806544
41DYRK21.13539795
42MAP3K41.11789422
43DYRK1B1.11385900
44CDC42BPA1.11234716
45SGK31.08831864
46CSNK1G31.05359210
47PAK31.04226562
48PTK2B1.03589348
49NTRK30.98036446
50MKNK20.95371134
51MST1R0.92056670
52PRKCG0.92043515
53CSNK1G20.86445622
54EPHB10.86086831
55ZAK0.85032958
56MYLK0.84523110
57EPHA20.84392060
58PRKD20.84196819
59FLT30.83844051
60MET0.80917220
61BMPR20.80331805
62STK240.78343744
63IRAK10.78243161
64NTRK10.75480550
65FGFR40.74164487
66PLK20.71843216
67STK38L0.71659894
68TAOK10.69846821
69NLK0.67956825
70FER0.67678976
71RET0.66373207
72CAMK2D0.59982045
73RPS6KA50.57474479
74KSR10.55737388
75TNIK0.55488819
76PRKCH0.53065143
77MAPKAPK30.51930270
78ERN10.51805748
79MOS0.51658897
80PTK20.48862142
81MAP2K20.47710753
82CAMK2A0.47379647
83PRKCZ0.46620738
84PRKCE0.45803434
85PRKG10.45265926
86PDPK10.44867666
87PDK10.44170424
88SCYL20.43917164
89CSK0.42865807
90MAP3K100.41197589
91GSK3A0.41170371
92SGK20.40690775
93ERBB30.40263725
94RIPK10.40259970
95EIF2AK30.39660019
96OXSR10.39622725
97PDGFRB0.39295550
98DAPK10.39125721
99NUAK10.38681934
100TLK10.38476672
101RPS6KB10.37801392
102MTOR0.37459935
103RAF10.37140784
104AKT20.37111526
105PINK10.36809202
106CSNK1A1L0.36532802
107MAP2K10.35450554
108DYRK30.34186499
109STK390.33096186
110SGK10.32867056
111CAMK2G0.32011694
112MARK20.31855241
113MAPK90.31311441
114PRKAA20.31253856
115PTK60.31018452
116CHUK0.29113292
117DAPK30.28409996
118PRKACB0.28262337
119CSNK1A10.28234262
120ATM0.27389879
121CDK50.27090574
122CSNK1D0.26893938
123BMPR1B0.26881862
124PRKCA0.26626932
125MAP2K40.26268352
126CAMK1G0.26106017
127DYRK1A0.25079340
128CAMKK20.24483364
129STK110.22869672
130EIF2AK10.22322953
131ADRBK20.21229121
132ERBB20.21130118
133CSNK1E0.20750900
134MAP2K70.20164899
135ITK0.19604121
136SIK10.18737490
137ADRBK10.18563681
138IRAK30.18298813
139PRKCI0.16777044
140RPS6KA40.16052748
141SGK4940.15954937
142SGK2230.15954937
143TESK10.15840380
144PRKACA0.15346977
145BCKDK0.15198790
146MAPK80.15108711
147MAPKAPK20.14443404
148PRKAA10.14345903
149GRK70.14137157
150PRKDC0.13661374
151RPS6KA10.13490679
152PRKD10.12039788
153PRKG20.11749152
154RPS6KA30.11739969
155FGFR30.09723916
156AKT10.09674717

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.84264707
2Protein export_Homo sapiens_hsa030606.18106777
3* Insulin secretion_Homo sapiens_hsa049113.30139150
4Vibrio cholerae infection_Homo sapiens_hsa051102.97356695
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.74374166
6Sulfur metabolism_Homo sapiens_hsa009202.36640812
7Fatty acid elongation_Homo sapiens_hsa000621.97158863
8Type II diabetes mellitus_Homo sapiens_hsa049301.96221263
9Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.89856674
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.85994572
11Vitamin B6 metabolism_Homo sapiens_hsa007501.80555608
12Folate biosynthesis_Homo sapiens_hsa007901.77185710
13Regulation of autophagy_Homo sapiens_hsa041401.75644843
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.63898832
15Type I diabetes mellitus_Homo sapiens_hsa049401.62003724
16Cocaine addiction_Homo sapiens_hsa050301.58220880
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51222876
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.49335410
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47920923
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42793780
21Thyroid hormone synthesis_Homo sapiens_hsa049181.41047728
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.31690487
23GABAergic synapse_Homo sapiens_hsa047271.28854777
24Peroxisome_Homo sapiens_hsa041461.27183365
25Amphetamine addiction_Homo sapiens_hsa050311.25881611
26Sphingolipid metabolism_Homo sapiens_hsa006001.25439642
27Circadian entrainment_Homo sapiens_hsa047131.24492945
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24462929
29Arginine biosynthesis_Homo sapiens_hsa002201.21980491
30Mineral absorption_Homo sapiens_hsa049781.19256281
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18184072
32Lysosome_Homo sapiens_hsa041421.09756949
33Estrogen signaling pathway_Homo sapiens_hsa049151.09192157
34Propanoate metabolism_Homo sapiens_hsa006401.08221460
35Other glycan degradation_Homo sapiens_hsa005111.06738697
36Glucagon signaling pathway_Homo sapiens_hsa049221.04355608
37Phototransduction_Homo sapiens_hsa047441.03821277
38Circadian rhythm_Homo sapiens_hsa047101.01842071
39Linoleic acid metabolism_Homo sapiens_hsa005911.01643852
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01131069
41Vascular smooth muscle contraction_Homo sapiens_hsa042700.99951577
42Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97440283
43Prion diseases_Homo sapiens_hsa050200.94837580
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94430539
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93486412
46Dopaminergic synapse_Homo sapiens_hsa047280.92529324
47Pancreatic secretion_Homo sapiens_hsa049720.91914414
48Glutathione metabolism_Homo sapiens_hsa004800.91869697
49Fatty acid metabolism_Homo sapiens_hsa012120.91331832
50Retinol metabolism_Homo sapiens_hsa008300.90005396
51Cholinergic synapse_Homo sapiens_hsa047250.89638117
52beta-Alanine metabolism_Homo sapiens_hsa004100.88610989
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88231478
54Synaptic vesicle cycle_Homo sapiens_hsa047210.82501013
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80128898
56Cardiac muscle contraction_Homo sapiens_hsa042600.80080294
57Oxidative phosphorylation_Homo sapiens_hsa001900.79755823
58Butanoate metabolism_Homo sapiens_hsa006500.78939245
59Morphine addiction_Homo sapiens_hsa050320.77959771
60Fatty acid degradation_Homo sapiens_hsa000710.77683891
61Renin secretion_Homo sapiens_hsa049240.77342636
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75672528
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75317826
64Metabolic pathways_Homo sapiens_hsa011000.75155064
65Melanogenesis_Homo sapiens_hsa049160.71470209
66N-Glycan biosynthesis_Homo sapiens_hsa005100.71165030
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70886113
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70631634
69Serotonergic synapse_Homo sapiens_hsa047260.70141113
70ABC transporters_Homo sapiens_hsa020100.70007801
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.69590755
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68937790
73Collecting duct acid secretion_Homo sapiens_hsa049660.67710171
74Ether lipid metabolism_Homo sapiens_hsa005650.67707361
75Selenocompound metabolism_Homo sapiens_hsa004500.66309981
76Ovarian steroidogenesis_Homo sapiens_hsa049130.66099014
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.65522947
78Phenylalanine metabolism_Homo sapiens_hsa003600.64413260
79Complement and coagulation cascades_Homo sapiens_hsa046100.62849681
80Tyrosine metabolism_Homo sapiens_hsa003500.62230191
81Gastric acid secretion_Homo sapiens_hsa049710.62185021
82Glutamatergic synapse_Homo sapiens_hsa047240.61161096
83RNA polymerase_Homo sapiens_hsa030200.59342524
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57731961
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56553457
86Parkinsons disease_Homo sapiens_hsa050120.55974270
87Pentose phosphate pathway_Homo sapiens_hsa000300.53425090
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53162650
89* cAMP signaling pathway_Homo sapiens_hsa040240.52768330
90Nitrogen metabolism_Homo sapiens_hsa009100.52328267
91Long-term depression_Homo sapiens_hsa047300.52267900
92Prolactin signaling pathway_Homo sapiens_hsa049170.51322427
93Alzheimers disease_Homo sapiens_hsa050100.50750289
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50737099
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50622050
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50031169
97Chemical carcinogenesis_Homo sapiens_hsa052040.49800604
98Nicotine addiction_Homo sapiens_hsa050330.49513947
99Tryptophan metabolism_Homo sapiens_hsa003800.49147944
100Caffeine metabolism_Homo sapiens_hsa002320.48893489
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47535648
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47258675
103Long-term potentiation_Homo sapiens_hsa047200.47067606
104GnRH signaling pathway_Homo sapiens_hsa049120.45243225
105Gap junction_Homo sapiens_hsa045400.44874702
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44484508
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44469873
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44361850
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43845542
110Histidine metabolism_Homo sapiens_hsa003400.43684848
111Bile secretion_Homo sapiens_hsa049760.42920921
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.42515192
113Steroid biosynthesis_Homo sapiens_hsa001000.42318359
114Insulin resistance_Homo sapiens_hsa049310.42246316
115Fat digestion and absorption_Homo sapiens_hsa049750.41856717
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41096816
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40936315
118Alcoholism_Homo sapiens_hsa050340.40761563
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35980693
120Oxytocin signaling pathway_Homo sapiens_hsa049210.35284223
121Arachidonic acid metabolism_Homo sapiens_hsa005900.35133343
122Basal transcription factors_Homo sapiens_hsa030220.35107291
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34035376
124Salivary secretion_Homo sapiens_hsa049700.32552033
125Galactose metabolism_Homo sapiens_hsa000520.32199223
126Dilated cardiomyopathy_Homo sapiens_hsa054140.31343249
127Vitamin digestion and absorption_Homo sapiens_hsa049770.31003099
128Thyroid cancer_Homo sapiens_hsa052160.30284106
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29979351
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28905723
131Insulin signaling pathway_Homo sapiens_hsa049100.28860553
132Starch and sucrose metabolism_Homo sapiens_hsa005000.28355510
133Taste transduction_Homo sapiens_hsa047420.26600885
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24892974
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23757487
136Renin-angiotensin system_Homo sapiens_hsa046140.19008734
137Huntingtons disease_Homo sapiens_hsa050160.17658816
138Arginine and proline metabolism_Homo sapiens_hsa003300.16796900
139Phagosome_Homo sapiens_hsa041450.16647358
140Dorso-ventral axis formation_Homo sapiens_hsa043200.15624408

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