

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NIK/NF-kappaB signaling (GO:0038061) | 6.07890986 |
| 2 | positive regulation of gamma-delta T cell activation (GO:0046645) | 5.88932717 |
| 3 | regulation of gamma-delta T cell differentiation (GO:0045586) | 5.65047564 |
| 4 | antigen processing and presentation of endogenous antigen (GO:0019883) | 5.46061987 |
| 5 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 5.45289996 |
| 6 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 5.45289996 |
| 7 | regulation of gamma-delta T cell activation (GO:0046643) | 5.36509692 |
| 8 | regulation of T-helper 1 cell differentiation (GO:0045625) | 5.25060648 |
| 9 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 5.20580444 |
| 10 | negative regulation of cell killing (GO:0031342) | 5.15915482 |
| 11 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 5.15915482 |
| 12 | negative T cell selection (GO:0043383) | 5.14738193 |
| 13 | negative thymic T cell selection (GO:0045060) | 5.11391746 |
| 14 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 5.02688767 |
| 15 | negative regulation of interleukin-12 production (GO:0032695) | 4.80270097 |
| 16 | positive thymic T cell selection (GO:0045059) | 4.76030584 |
| 17 | interferon-gamma production (GO:0032609) | 4.69938528 |
| 18 | regulation of vitamin D biosynthetic process (GO:0060556) | 4.61074344 |
| 19 | tolerance induction (GO:0002507) | 4.52340906 |
| 20 | response to interleukin-15 (GO:0070672) | 4.51537904 |
| 21 | response to peptidoglycan (GO:0032494) | 4.46768813 |
| 22 | thymic T cell selection (GO:0045061) | 4.41561386 |
| 23 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.30690121 |
| 24 | T cell selection (GO:0045058) | 4.29477671 |
| 25 | cellular response to interleukin-15 (GO:0071350) | 4.27688030 |
| 26 | response to muramyl dipeptide (GO:0032495) | 4.26298054 |
| 27 | T cell migration (GO:0072678) | 4.26280523 |
| 28 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 4.20904725 |
| 29 | macrophage activation involved in immune response (GO:0002281) | 4.16244179 |
| 30 | positive T cell selection (GO:0043368) | 4.16208633 |
| 31 | positive regulation of interleukin-2 production (GO:0032743) | 4.15309609 |
| 32 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 4.06368244 |
| 33 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 4.06368244 |
| 34 | modulation by symbiont of host immune response (GO:0052553) | 4.06368244 |
| 35 | positive regulation by symbiont of host defense response (GO:0052509) | 4.06368244 |
| 36 | modulation by symbiont of host defense response (GO:0052031) | 4.06368244 |
| 37 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 4.06368244 |
| 38 | regulation of interferon-alpha production (GO:0032647) | 4.05599970 |
| 39 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 4.05244788 |
| 40 | T-helper cell differentiation (GO:0042093) | 4.05244788 |
| 41 | myeloid dendritic cell differentiation (GO:0043011) | 3.99198164 |
| 42 | defense response to protozoan (GO:0042832) | 3.89922480 |
| 43 | myeloid dendritic cell activation (GO:0001773) | 3.85198550 |
| 44 | leukocyte aggregation (GO:0070486) | 3.83002064 |
| 45 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 3.82834243 |
| 46 | response to protozoan (GO:0001562) | 3.81055777 |
| 47 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.74689531 |
| 48 | regulation of cytokine secretion involved in immune response (GO:0002739) | 3.73518106 |
| 49 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 3.73197436 |
| 50 | regulation of alpha-beta T cell proliferation (GO:0046640) | 3.68365529 |
| 51 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.68016982 |
| 52 | germinal center formation (GO:0002467) | 3.66581066 |
| 53 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 3.65698132 |
| 54 | regulation of T cell tolerance induction (GO:0002664) | 3.63863785 |
| 55 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.60305634 |
| 56 | alpha-beta T cell differentiation involved in immune response (GO:0002293) | 3.56943243 |
| 57 | alpha-beta T cell activation involved in immune response (GO:0002287) | 3.56943243 |
| 58 | T cell differentiation involved in immune response (GO:0002292) | 3.56943243 |
| 59 | T-helper 1 type immune response (GO:0042088) | 3.56679755 |
| 60 | regulation of vitamin metabolic process (GO:0030656) | 3.56373877 |
| 61 | positive regulation of interferon-alpha production (GO:0032727) | 3.55788132 |
| 62 | regulation of T-helper 2 cell differentiation (GO:0045628) | 3.54222162 |
| 63 | positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 3.52673403 |
| 64 | negative regulation of cytokine production involved in immune response (GO:0002719) | 3.51518763 |
| 65 | T cell receptor signaling pathway (GO:0050852) | 3.43322632 |
| 66 | positive regulation of chemokine biosynthetic process (GO:0045080) | 3.43111510 |
| 67 | alpha-beta T cell activation (GO:0046631) | 3.42690236 |
| 68 | positive regulation of type 2 immune response (GO:0002830) | 3.38361339 |
| 69 | positive regulation of interleukin-12 production (GO:0032735) | 3.37315730 |
| 70 | neutrophil activation involved in immune response (GO:0002283) | 3.36966183 |
| 71 | regulation of B cell differentiation (GO:0045577) | 3.35365540 |
| 72 | mature B cell differentiation (GO:0002335) | 3.34104353 |
| 73 | regulation of memory T cell differentiation (GO:0043380) | 3.32179557 |
| 74 | regulation of chemokine biosynthetic process (GO:0045073) | 3.31637208 |
| 75 | detection of other organism (GO:0098543) | 3.31527520 |
| 76 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 3.31074305 |
| 77 | alpha-beta T cell differentiation (GO:0046632) | 3.30591385 |
| 78 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 3.30442684 |
| 79 | positive regulation of B cell differentiation (GO:0045579) | 3.29597198 |
| 80 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 3.28875774 |
| 81 | T cell costimulation (GO:0031295) | 3.28762310 |
| 82 | regulation of response to interferon-gamma (GO:0060330) | 3.28038765 |
| 83 | regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370) | 3.27379342 |
| 84 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.27163743 |
| 85 | negative regulation of T cell mediated immunity (GO:0002710) | 3.26791176 |
| 86 | positive regulation of humoral immune response (GO:0002922) | 3.23071095 |
| 87 | lymphocyte costimulation (GO:0031294) | 3.22928178 |
| 88 | response to type I interferon (GO:0034340) | 3.21391954 |
| 89 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 3.19723203 |
| 90 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 3.19379515 |
| 91 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.19353087 |
| 92 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.19060111 |
| 93 | type I interferon signaling pathway (GO:0060337) | 3.18930874 |
| 94 | cellular response to type I interferon (GO:0071357) | 3.18930874 |
| 95 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 3.18106372 |
| 96 | regulation of antigen processing and presentation (GO:0002577) | 3.17536870 |
| 97 | antigen receptor-mediated signaling pathway (GO:0050851) | 3.16928530 |
| 98 | T cell activation involved in immune response (GO:0002286) | 3.15734418 |
| 99 | detection of bacterium (GO:0016045) | 3.15090292 |
| 100 | regulation of podosome assembly (GO:0071801) | 3.14957699 |
| 101 | regulation of interleukin-2 production (GO:0032663) | 3.14461096 |
| 102 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.12682965 |
| 103 | regulation of activation of Janus kinase activity (GO:0010533) | 3.12169047 |
| 104 | natural killer cell activation (GO:0030101) | 3.11743367 |
| 105 | regulation of type 2 immune response (GO:0002828) | 3.09937713 |
| 106 | positive regulation of NF-kappaB import into nucleus (GO:0042346) | 3.09475312 |
| 107 | positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516) | 3.08584982 |
| 108 | positive regulation of isotype switching (GO:0045830) | 3.08236461 |
| 109 | regulation of T cell receptor signaling pathway (GO:0050856) | 3.07061311 |
| 110 | CD4-positive, alpha-beta T cell differentiation (GO:0043367) | 3.06441654 |
| 111 | regulation of regulatory T cell differentiation (GO:0045589) | 3.05400966 |
| 112 | regulation of interleukin-12 production (GO:0032655) | 3.03486328 |
| 113 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 3.03147812 |
| 114 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 3.02396250 |
| 115 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 3.02246570 |
| 116 | positive regulation of heat generation (GO:0031652) | 3.01393982 |
| 117 | positive regulation of antigen processing and presentation (GO:0002579) | 2.98767238 |
| 118 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 2.98387882 |
| 119 | regulation of fever generation (GO:0031620) | 2.98308935 |
| 120 | positive regulation of T-helper 1 type immune response (GO:0002827) | 2.97068228 |
| 121 | regulation of CD4-positive, alpha-beta T cell activation (GO:2000514) | 2.96107626 |
| 122 | positive regulation of interleukin-17 production (GO:0032740) | 2.95967604 |
| 123 | myeloid cell activation involved in immune response (GO:0002275) | 2.95012226 |
| 124 | negative regulation of growth of symbiont in host (GO:0044130) | 2.95007086 |
| 125 | negative regulation of growth of symbiont involved in interaction with host (GO:0044146) | 2.95007086 |
| 126 | modulation of growth of symbiont involved in interaction with host (GO:0044144) | 2.95007086 |
| 127 | regulation of growth of symbiont in host (GO:0044126) | 2.95007086 |
| 128 | positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725) | 2.94922567 |
| 129 | B cell mediated immunity (GO:0019724) | 2.94796185 |
| 130 | positive regulation of T cell differentiation (GO:0045582) | 2.94393610 |
| 131 | immunoglobulin mediated immune response (GO:0016064) | 2.94292670 |
| 132 | negative regulation of toll-like receptor 4 signaling pathway (GO:0034144) | 2.93954070 |
| 133 | neutrophil activation (GO:0042119) | 2.93024282 |
| 134 | cellular response to interferon-gamma (GO:0071346) | 2.92912094 |
| 135 | regulation of T-helper cell differentiation (GO:0045622) | 2.92771566 |
| 136 | positive regulation of natural killer cell differentiation (GO:0032825) | 2.92692543 |
| 137 | positive regulation of interferon-beta production (GO:0032728) | 2.92131757 |
| 138 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 2.92042833 |
| 139 | B cell receptor signaling pathway (GO:0050853) | 2.91614593 |
| 140 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 2.90917476 |
| 141 | regulation of natural killer cell mediated immunity (GO:0002715) | 2.90917476 |
| 142 | negative regulation of type 2 immune response (GO:0002829) | 2.90831144 |
| 143 | endothelial cell chemotaxis (GO:0035767) | 2.90505186 |
| 144 | positive regulation of T-helper cell differentiation (GO:0045624) | 2.90194120 |
| 145 | regulation of T-helper 1 type immune response (GO:0002825) | 2.89974443 |
| 146 | regulation of T cell mediated cytotoxicity (GO:0001914) | 2.89841127 |
| 147 | granulocyte activation (GO:0036230) | 2.89831928 |
| 148 | dendritic cell differentiation (GO:0097028) | 2.89489029 |
| 149 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 2.88525557 |
| 150 | lymphocyte migration (GO:0072676) | 2.88523421 |
| 151 | positive regulation of B cell mediated immunity (GO:0002714) | 2.88404074 |
| 152 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 2.88404074 |
| 153 | regulation of chronic inflammatory response (GO:0002676) | 2.87479924 |
| 154 | CD4-positive, alpha-beta T cell activation (GO:0035710) | 2.87333296 |
| 155 | positive regulation of cytokine biosynthetic process (GO:0042108) | 2.87103408 |
| 156 | positive regulation of defense response to virus by host (GO:0002230) | 2.86231659 |
| 157 | negative regulation of T-helper cell differentiation (GO:0045623) | 2.86164894 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 6.64008219 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 5.63391650 |
| 3 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 5.09272609 |
| 4 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 4.08668827 |
| 5 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.90778941 |
| 6 | * STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.65927109 |
| 7 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 3.62057460 |
| 8 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.45984763 |
| 9 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 3.30854113 |
| 10 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 3.25411552 |
| 11 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.24647225 |
| 12 | * FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 3.15371125 |
| 13 | MYC_22102868_ChIP-Seq_BL_Human | 3.14139993 |
| 14 | RUNX_20019798_ChIP-Seq_JUKART_Human | 3.11658332 |
| 15 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.97542827 |
| 16 | * MYB_26560356_Chip-Seq_TH2_Human | 2.93700010 |
| 17 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.92563818 |
| 18 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.83933833 |
| 19 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.79107874 |
| 20 | MAF_26560356_Chip-Seq_TH1_Human | 2.72787459 |
| 21 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.66601999 |
| 22 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.63633538 |
| 23 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.52995838 |
| 24 | * MYB_26560356_Chip-Seq_TH1_Human | 2.47229060 |
| 25 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.44504127 |
| 26 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.37792639 |
| 27 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.36998582 |
| 28 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 2.36092919 |
| 29 | TCF7_22412390_ChIP-Seq_EML_Mouse | 2.22512532 |
| 30 | UTX_26944678_Chip-Seq_JUKART_Human | 2.16960525 |
| 31 | VDR_24763502_ChIP-Seq_THP-1_Human | 2.08196082 |
| 32 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.02297368 |
| 33 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.99566743 |
| 34 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.96034811 |
| 35 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.95295926 |
| 36 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.93569556 |
| 37 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.93497784 |
| 38 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.84659999 |
| 39 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.84524308 |
| 40 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.79395823 |
| 41 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.75990747 |
| 42 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.74351352 |
| 43 | * MAF_26560356_Chip-Seq_TH2_Human | 1.71496556 |
| 44 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.68044759 |
| 45 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.66583992 |
| 46 | * KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.61822901 |
| 47 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.59984440 |
| 48 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.46464550 |
| 49 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.42937710 |
| 50 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.42710266 |
| 51 | SPI1_23127762_ChIP-Seq_K562_Human | 1.42402070 |
| 52 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.38936377 |
| 53 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.33043861 |
| 54 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.32695945 |
| 55 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.31222690 |
| 56 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.26920103 |
| 57 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.26448696 |
| 58 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.24583126 |
| 59 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.24101977 |
| 60 | GATA3_26560356_Chip-Seq_TH2_Human | 1.20965064 |
| 61 | * VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.19741833 |
| 62 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.14202920 |
| 63 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.13997459 |
| 64 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.12703895 |
| 65 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.10407841 |
| 66 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.09901618 |
| 67 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.09698229 |
| 68 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.09240396 |
| 69 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.03937119 |
| 70 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.00334651 |
| 71 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.98917972 |
| 72 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.98515330 |
| 73 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.96768588 |
| 74 | * GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.96619900 |
| 75 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.96481153 |
| 76 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.94063056 |
| 77 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.91763142 |
| 78 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.91588356 |
| 79 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.91385112 |
| 80 | * GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.90506515 |
| 81 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.89836768 |
| 82 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.89015892 |
| 83 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.88927703 |
| 84 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.88519602 |
| 85 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.87754672 |
| 86 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.87335632 |
| 87 | * LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.84069038 |
| 88 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.81312328 |
| 89 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.79629764 |
| 90 | * SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.78619386 |
| 91 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.78274196 |
| 92 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 0.75968505 |
| 93 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.75364556 |
| 94 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.75224764 |
| 95 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.74654490 |
| 96 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.74613635 |
| 97 | GATA2_19941826_ChIP-Seq_K562_Human | 0.73702027 |
| 98 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.72240200 |
| 99 | GATA1_19941826_ChIP-Seq_K562_Human | 0.72159991 |
| 100 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.71890860 |
| 101 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.70992354 |
| 102 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.70145159 |
| 103 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.69635789 |
| 104 | * RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.69190641 |
| 105 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.68121604 |
| 106 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.68070229 |
| 107 | GATA1_22025678_ChIP-Seq_K562_Human | 0.66737956 |
| 108 | CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.66722014 |
| 109 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.66703094 |
| 110 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.66208365 |
| 111 | * GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.65445473 |
| 112 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.65085133 |
| 113 | ETS1_22383799_ChIP-Seq_G1ME_Mouse | 0.65042357 |
| 114 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.64638145 |
| 115 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.64241432 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 4.13377421 |
| 2 | MP0000685_abnormal_immune_system | 4.04601063 |
| 3 | MP0005671_abnormal_response_to | 3.60423933 |
| 4 | MP0003763_abnormal_thymus_physiology | 3.49149588 |
| 5 | MP0005387_immune_system_phenotype | 3.48416816 |
| 6 | MP0001790_abnormal_immune_system | 3.48416816 |
| 7 | MP0004510_myositis | 3.28254451 |
| 8 | * MP0001800_abnormal_humoral_immune | 3.23646324 |
| 9 | MP0003436_decreased_susceptibility_to | 3.23051363 |
| 10 | * MP0005000_abnormal_immune_tolerance | 3.11617497 |
| 11 | MP0009785_altered_susceptibility_to | 3.09540292 |
| 12 | * MP0002723_abnormal_immune_serum | 2.86646370 |
| 13 | * MP0002452_abnormal_antigen_presenting | 2.81683379 |
| 14 | MP0003303_peritoneal_inflammation | 2.77914253 |
| 15 | * MP0002420_abnormal_adaptive_immunity | 2.68480467 |
| 16 | * MP0001819_abnormal_immune_cell | 2.67904876 |
| 17 | MP0002148_abnormal_hypersensitivity_rea | 2.59907212 |
| 18 | MP0005025_abnormal_response_to | 2.56963187 |
| 19 | MP0002166_altered_tumor_susceptibility | 2.51855517 |
| 20 | MP0002138_abnormal_hepatobiliary_system | 2.46263009 |
| 21 | * MP0002398_abnormal_bone_marrow | 2.40916842 |
| 22 | * MP0002419_abnormal_innate_immunity | 2.36756773 |
| 23 | * MP0002405_respiratory_system_inflammati | 2.31064883 |
| 24 | MP0001853_heart_inflammation | 2.25048095 |
| 25 | MP0010155_abnormal_intestine_physiology | 2.24060342 |
| 26 | * MP0000716_abnormal_immune_system | 2.23503171 |
| 27 | MP0004947_skin_inflammation | 2.21338719 |
| 28 | MP0003724_increased_susceptibility_to | 2.19815566 |
| 29 | MP0002006_tumorigenesis | 2.15431502 |
| 30 | MP0001873_stomach_inflammation | 2.15095634 |
| 31 | MP0006082_CNS_inflammation | 2.05748235 |
| 32 | MP0009333_abnormal_splenocyte_physiolog | 2.02790039 |
| 33 | MP0000703_abnormal_thymus_morphology | 1.94672358 |
| 34 | MP0003300_gastrointestinal_ulcer | 1.93129867 |
| 35 | * MP0002722_abnormal_immune_system | 1.90618564 |
| 36 | * MP0000689_abnormal_spleen_morphology | 1.89690009 |
| 37 | * MP0001845_abnormal_inflammatory_respons | 1.79714341 |
| 38 | * MP0002429_abnormal_blood_cell | 1.79676184 |
| 39 | MP0005310_abnormal_salivary_gland | 1.75570883 |
| 40 | MP0005451_abnormal_body_composition | 1.70912777 |
| 41 | MP0003866_abnormal_defecation | 1.68973738 |
| 42 | MP0005464_abnormal_platelet_physiology | 1.67577492 |
| 43 | MP0004808_abnormal_hematopoietic_stem | 1.66623704 |
| 44 | MP0002396_abnormal_hematopoietic_system | 1.59713432 |
| 45 | MP0008004_abnormal_stomach_pH | 1.59535041 |
| 46 | MP0005397_hematopoietic_system_phenotyp | 1.49474474 |
| 47 | MP0001545_abnormal_hematopoietic_system | 1.49474474 |
| 48 | MP0002933_joint_inflammation | 1.47878045 |
| 49 | MP0001533_abnormal_skeleton_physiology | 1.47613482 |
| 50 | MP0009278_abnormal_bone_marrow | 1.46848692 |
| 51 | MP0009840_abnormal_foam_cell | 1.41390607 |
| 52 | MP0002254_reproductive_system_inflammat | 1.37142223 |
| 53 | MP0002332_abnormal_exercise_endurance | 1.36973003 |
| 54 | MP0003448_altered_tumor_morphology | 1.32328354 |
| 55 | MP0010352_gastrointestinal_tract_polyps | 1.31001730 |
| 56 | MP0001348_abnormal_lacrimal_gland | 1.29449875 |
| 57 | MP0002139_abnormal_hepatobiliary_system | 1.27334398 |
| 58 | MP0005167_abnormal_blood-brain_barrier | 1.27295821 |
| 59 | MP0002277_abnormal_respiratory_mucosa | 1.26139868 |
| 60 | MP0008469_abnormal_protein_level | 1.26089122 |
| 61 | MP0000858_altered_metastatic_potential | 1.25700448 |
| 62 | MP0005076_abnormal_cell_differentiation | 1.21040976 |
| 63 | MP0000465_gastrointestinal_hemorrhage | 1.20315568 |
| 64 | MP0002009_preneoplasia | 1.19026126 |
| 65 | MP0008057_abnormal_DNA_replication | 1.15909266 |
| 66 | MP0002998_abnormal_bone_remodeling | 1.15777519 |
| 67 | MP0003690_abnormal_glial_cell | 1.09103846 |
| 68 | MP0001851_eye_inflammation | 1.07849370 |
| 69 | MP0000490_abnormal_crypts_of | 1.07448806 |
| 70 | MP0009764_decreased_sensitivity_to | 1.04074788 |
| 71 | MP0003191_abnormal_cellular_cholesterol | 1.02483014 |
| 72 | MP0005174_abnormal_tail_pigmentation | 1.00740629 |
| 73 | MP0003656_abnormal_erythrocyte_physiolo | 1.00248650 |
| 74 | MP0002877_abnormal_melanocyte_morpholog | 0.93981126 |
| 75 | MP0005164_abnormal_response_to | 0.93796191 |
| 76 | MP0003453_abnormal_keratinocyte_physiol | 0.88431595 |
| 77 | MP0008961_abnormal_basal_metabolism | 0.86730851 |
| 78 | MP0001501_abnormal_sleep_pattern | 0.85739518 |
| 79 | MP0003195_calcinosis | 0.84567712 |
| 80 | MP0006054_spinal_hemorrhage | 0.82955187 |
| 81 | MP0004883_abnormal_blood_vessel | 0.81746816 |
| 82 | MP0002019_abnormal_tumor_incidence | 0.80755874 |
| 83 | MP0003806_abnormal_nucleotide_metabolis | 0.74505671 |
| 84 | MP0000604_amyloidosis | 0.73587689 |
| 85 | MP0008260_abnormal_autophagy | 0.73403765 |
| 86 | MP0000343_altered_response_to | 0.73340636 |
| 87 | MP0009763_increased_sensitivity_to | 0.72444614 |
| 88 | MP0003091_abnormal_cell_migration | 0.72155078 |
| 89 | MP0010307_abnormal_tumor_latency | 0.72125968 |
| 90 | MP0001881_abnormal_mammary_gland | 0.69754645 |
| 91 | MP0005165_increased_susceptibility_to | 0.69117833 |
| 92 | MP0003646_muscle_fatigue | 0.66827269 |
| 93 | MP0005535_abnormal_body_temperature | 0.66619949 |
| 94 | MP0003828_pulmonary_edema | 0.65795273 |
| 95 | MP0002693_abnormal_pancreas_physiology | 0.65753307 |
| 96 | MP0005390_skeleton_phenotype | 0.64895593 |
| 97 | MP0008874_decreased_physiological_sensi | 0.63900948 |
| 98 | MP0005084_abnormal_gallbladder_morpholo | 0.63653995 |
| 99 | * MP0000249_abnormal_blood_vessel | 0.63404863 |
| 100 | MP0000569_abnormal_digit_pigmentation | 0.62723409 |
| 101 | MP0001542_abnormal_bone_strength | 0.61889785 |
| 102 | MP0003795_abnormal_bone_structure | 0.61069436 |
| 103 | MP0009765_abnormal_xenobiotic_induced | 0.60649886 |
| 104 | MP0003045_fibrosis | 0.60175410 |
| 105 | MP0008007_abnormal_cellular_replicative | 0.60030045 |
| 106 | MP0005075_abnormal_melanosome_morpholog | 0.60005146 |
| 107 | MP0003172_abnormal_lysosome_physiology | 0.59978794 |
| 108 | MP0001663_abnormal_digestive_system | 0.59510023 |
| 109 | MP0003075_altered_response_to | 0.58803555 |
| 110 | MP0005058_abnormal_lysosome_morphology | 0.57113383 |
| 111 | MP0000920_abnormal_myelination | 0.55757670 |
| 112 | * MP0000609_abnormal_liver_physiology | 0.55654932 |
| 113 | MP0002163_abnormal_gland_morphology | 0.55436255 |
| 114 | MP0002132_abnormal_respiratory_system | 0.55379525 |
| 115 | MP0005166_decreased_susceptibility_to | 0.55225844 |
| 116 | * MP0002136_abnormal_kidney_physiology | 0.54377426 |
| 117 | MP0005647_abnormal_sex_gland | 0.52338410 |
| 118 | MP0001243_abnormal_dermal_layer | 0.50376575 |
| 119 | MP0003183_abnormal_peptide_metabolism | 0.50352931 |
| 120 | MP0001216_abnormal_epidermal_layer | 0.49348327 |
| 121 | MP0005023_abnormal_wound_healing | 0.49131519 |
| 122 | MP0001191_abnormal_skin_condition | 0.47491773 |
| 123 | MP0002928_abnormal_bile_duct | 0.45556444 |
| 124 | MP0000367_abnormal_coat/_hair | 0.45298333 |
| 125 | MP0008873_increased_physiological_sensi | 0.45138953 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myositis (HP:0100614) | 5.64172204 |
| 2 | Retrobulbar optic neuritis (HP:0100654) | 5.54417842 |
| 3 | Optic neuritis (HP:0100653) | 5.54417842 |
| 4 | Orchitis (HP:0100796) | 5.15036730 |
| 5 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.08728181 |
| 6 | Eczematoid dermatitis (HP:0000976) | 4.93952643 |
| 7 | T lymphocytopenia (HP:0005403) | 4.76290043 |
| 8 | Stomatitis (HP:0010280) | 4.76174656 |
| 9 | Abnormality of T cell number (HP:0011839) | 4.74809611 |
| 10 | Recurrent fungal infections (HP:0002841) | 4.72505541 |
| 11 | Abnormality of glycolipid metabolism (HP:0010969) | 4.57175926 |
| 12 | Abnormality of liposaccharide metabolism (HP:0010968) | 4.57175926 |
| 13 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 4.57175926 |
| 14 | Recurrent viral infections (HP:0004429) | 4.48780672 |
| 15 | Recurrent abscess formation (HP:0002722) | 4.21222251 |
| 16 | Chronic otitis media (HP:0000389) | 4.16229264 |
| 17 | Recurrent bacterial skin infections (HP:0005406) | 4.03400082 |
| 18 | IgM deficiency (HP:0002850) | 3.99702942 |
| 19 | Panhypogammaglobulinemia (HP:0003139) | 3.89713096 |
| 20 | Severe combined immunodeficiency (HP:0004430) | 3.89654663 |
| 21 | Recurrent bronchitis (HP:0002837) | 3.87915770 |
| 22 | Abnormality of T cells (HP:0002843) | 3.87497090 |
| 23 | Vasculitis (HP:0002633) | 3.86329676 |
| 24 | Pulmonary infiltrates (HP:0002113) | 3.84722384 |
| 25 | Nasal polyposis (HP:0100582) | 3.84046272 |
| 26 | Mediastinal lymphadenopathy (HP:0100721) | 3.81231345 |
| 27 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.76029701 |
| 28 | Keratoconjunctivitis sicca (HP:0001097) | 3.75206995 |
| 29 | Increased density of long bones (HP:0006392) | 3.67835223 |
| 30 | Thyroiditis (HP:0100646) | 3.64659171 |
| 31 | Recurrent cutaneous fungal infections (HP:0011370) | 3.63585761 |
| 32 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.63585761 |
| 33 | Combined immunodeficiency (HP:0005387) | 3.58988279 |
| 34 | Keratoconjunctivitis (HP:0001096) | 3.48193107 |
| 35 | Arterial thrombosis (HP:0004420) | 3.48032238 |
| 36 | Persistence of primary teeth (HP:0006335) | 3.43364990 |
| 37 | Meningitis (HP:0001287) | 3.37197509 |
| 38 | Abnormality of eosinophils (HP:0001879) | 3.35245180 |
| 39 | Abnormality of the nasal mucosa (HP:0000433) | 3.31034544 |
| 40 | Vacuolated lymphocytes (HP:0001922) | 3.29654117 |
| 41 | Abnormality of the fingertips (HP:0001211) | 3.29063806 |
| 42 | Leukocytosis (HP:0001974) | 3.26197273 |
| 43 | IgG deficiency (HP:0004315) | 3.25410732 |
| 44 | Recurrent skin infections (HP:0001581) | 3.24019982 |
| 45 | Hemoptysis (HP:0002105) | 3.20698234 |
| 46 | B lymphocytopenia (HP:0010976) | 3.18709158 |
| 47 | Abnormality of B cell number (HP:0010975) | 3.18709158 |
| 48 | Autoimmune thrombocytopenia (HP:0001973) | 3.18434047 |
| 49 | Eosinophilia (HP:0001880) | 3.16965570 |
| 50 | Loss of speech (HP:0002371) | 3.16510547 |
| 51 | Gastrointestinal infarctions (HP:0005244) | 3.15235180 |
| 52 | Dysostosis multiplex (HP:0000943) | 3.10804752 |
| 53 | Pustule (HP:0200039) | 3.05148194 |
| 54 | Abnormality of T cell physiology (HP:0011840) | 3.03891904 |
| 55 | Increased IgE level (HP:0003212) | 3.03397537 |
| 56 | Increased IgM level (HP:0003496) | 2.99270804 |
| 57 | Increased cerebral lipofuscin (HP:0011813) | 2.97639054 |
| 58 | Inflammation of the large intestine (HP:0002037) | 2.97374514 |
| 59 | Systemic lupus erythematosus (HP:0002725) | 2.97139891 |
| 60 | Encephalitis (HP:0002383) | 2.97072525 |
| 61 | Agammaglobulinemia (HP:0004432) | 2.91903048 |
| 62 | Thrombocytosis (HP:0001894) | 2.87902564 |
| 63 | Gastrointestinal inflammation (HP:0004386) | 2.85867190 |
| 64 | Disinhibition (HP:0000734) | 2.84094548 |
| 65 | Lymphopenia (HP:0001888) | 2.83522996 |
| 66 | Obstructive lung disease (HP:0006536) | 2.83211780 |
| 67 | Chronic obstructive pulmonary disease (HP:0006510) | 2.83211780 |
| 68 | Colitis (HP:0002583) | 2.81001043 |
| 69 | Abnormality of macrophages (HP:0004311) | 2.80050937 |
| 70 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.78331422 |
| 71 | Granulocytopenia (HP:0001913) | 2.78215276 |
| 72 | Gastrointestinal stroma tumor (HP:0100723) | 2.76636671 |
| 73 | Spontaneous hematomas (HP:0007420) | 2.73315847 |
| 74 | IgA deficiency (HP:0002720) | 2.70642201 |
| 75 | Cellulitis (HP:0100658) | 2.69390819 |
| 76 | Joint swelling (HP:0001386) | 2.65880205 |
| 77 | Interstitial pulmonary disease (HP:0006530) | 2.65027115 |
| 78 | Polyneuropathy (HP:0001271) | 2.61796422 |
| 79 | Chronic diarrhea (HP:0002028) | 2.61503642 |
| 80 | Urticaria (HP:0001025) | 2.59856902 |
| 81 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.55182476 |
| 82 | Hypergammaglobulinemia (HP:0010702) | 2.54701833 |
| 83 | Chest pain (HP:0100749) | 2.44470417 |
| 84 | Parakeratosis (HP:0001036) | 2.42350112 |
| 85 | Gingivitis (HP:0000230) | 2.40530020 |
| 86 | Increased serum ferritin (HP:0003281) | 2.37469899 |
| 87 | Emphysema (HP:0002097) | 2.37184165 |
| 88 | Pulmonary embolism (HP:0002204) | 2.36764200 |
| 89 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 2.36337182 |
| 90 | Gingival bleeding (HP:0000225) | 2.34061704 |
| 91 | Osteomyelitis (HP:0002754) | 2.32822105 |
| 92 | Lymphoma (HP:0002665) | 2.29602977 |
| 93 | Amyloidosis (HP:0011034) | 2.27519071 |
| 94 | Fatigue (HP:0012378) | 2.27223160 |
| 95 | Mutism (HP:0002300) | 2.26148677 |
| 96 | Restrictive lung disease (HP:0002091) | 2.25547646 |
| 97 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.24572712 |
| 98 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.24572712 |
| 99 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.24572712 |
| 100 | Recurrent sinusitis (HP:0011108) | 2.24240664 |
| 101 | Periodontitis (HP:0000704) | 2.23683838 |
| 102 | Anorexia (HP:0002039) | 2.22401161 |
| 103 | Verrucae (HP:0200043) | 2.21824348 |
| 104 | Papilloma (HP:0012740) | 2.21824348 |
| 105 | Episodic fever (HP:0001954) | 2.21471722 |
| 106 | Chronic sinusitis (HP:0011109) | 2.21181903 |
| 107 | Autoimmune hemolytic anemia (HP:0001890) | 2.19840626 |
| 108 | Vertigo (HP:0002321) | 2.18647866 |
| 109 | Gangrene (HP:0100758) | 2.17573412 |
| 110 | Abnormality of the pericardium (HP:0001697) | 2.16122235 |
| 111 | Epistaxis (HP:0000421) | 2.16092370 |
| 112 | Arthralgia (HP:0002829) | 2.10332878 |
| 113 | Petechiae (HP:0000967) | 2.08987743 |
| 114 | Bronchitis (HP:0012387) | 2.08698676 |
| 115 | Abnormality of the prostate (HP:0008775) | 2.06915094 |
| 116 | Glomerulopathy (HP:0100820) | 2.06715209 |
| 117 | Purpura (HP:0000979) | 2.04715328 |
| 118 | Premature loss of primary teeth (HP:0006323) | 2.04485465 |
| 119 | Mucopolysacchariduria (HP:0008155) | 2.03904496 |
| 120 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.03904496 |
| 121 | Hematochezia (HP:0002573) | 2.03382228 |
| 122 | Prolonged bleeding time (HP:0003010) | 1.99827839 |
| 123 | Keratitis (HP:0000491) | 1.98418130 |
| 124 | Myocardial infarction (HP:0001658) | 1.98104090 |
| 125 | Amaurosis fugax (HP:0100576) | 1.96947899 |
| 126 | Abnormality of the pleura (HP:0002103) | 1.96755425 |
| 127 | Abnormality of the endocardium (HP:0004306) | 1.95238833 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP4K1 | 4.94719733 |
| 2 | TXK | 4.74911104 |
| 3 | MAP3K14 | 4.21930657 |
| 4 | PRPF4B | 2.98902035 |
| 5 | JAK3 | 2.98207661 |
| 6 | TYK2 | 2.95928342 |
| 7 | TBK1 | 2.81914310 |
| 8 | IKBKE | 2.79566029 |
| 9 | IKBKB | 2.67519484 |
| 10 | IRAK3 | 2.63379567 |
| 11 | JAK1 | 2.37349179 |
| 12 | GRK7 | 2.35060474 |
| 13 | TAOK3 | 2.30776133 |
| 14 | ZAP70 | 2.22544779 |
| 15 | ITK | 2.18311942 |
| 16 | CHUK | 2.10641449 |
| 17 | TAOK2 | 2.09673527 |
| 18 | BMPR2 | 2.02066433 |
| 19 | MAP3K13 | 1.96238874 |
| 20 | GRK6 | 1.95355501 |
| 21 | FGFR4 | 1.80327776 |
| 22 | EEF2K | 1.76365145 |
| 23 | IRAK4 | 1.74841480 |
| 24 | BTK | 1.74763745 |
| 25 | STK10 | 1.74023393 |
| 26 | TEC | 1.69318809 |
| 27 | EPHB1 | 1.68400728 |
| 28 | PIM1 | 1.68079634 |
| 29 | FGR | 1.66306554 |
| 30 | NLK | 1.63207409 |
| 31 | MAP3K10 | 1.62730677 |
| 32 | KIT | 1.60507595 |
| 33 | SYK | 1.56949715 |
| 34 | TAOK1 | 1.55757409 |
| 35 | FGFR3 | 1.45561360 |
| 36 | LCK | 1.45020730 |
| 37 | DDR2 | 1.44243675 |
| 38 | HCK | 1.37743727 |
| 39 | CDC42BPA | 1.37359119 |
| 40 | BLK | 1.35168248 |
| 41 | EPHA3 | 1.32335220 |
| 42 | RIPK4 | 1.28532883 |
| 43 | CSK | 1.23141194 |
| 44 | RPS6KA4 | 1.21885080 |
| 45 | RIPK1 | 1.20548923 |
| 46 | CDK12 | 1.15912512 |
| 47 | IRAK2 | 1.12543093 |
| 48 | MOS | 1.09349682 |
| 49 | MST4 | 1.08656247 |
| 50 | CSF1R | 1.08611070 |
| 51 | SIK2 | 1.07263048 |
| 52 | MARK3 | 1.04665586 |
| 53 | JAK2 | 1.02848692 |
| 54 | ADRBK2 | 0.94597684 |
| 55 | SIK3 | 0.93995035 |
| 56 | PIM2 | 0.93613304 |
| 57 | MAP2K3 | 0.92334300 |
| 58 | TGFBR2 | 0.92114296 |
| 59 | MAP3K1 | 0.89811235 |
| 60 | LRRK2 | 0.89170384 |
| 61 | FLT3 | 0.85816028 |
| 62 | ERN1 | 0.82280557 |
| 63 | PRKCQ | 0.81889081 |
| 64 | LYN | 0.80475461 |
| 65 | TSSK6 | 0.79703714 |
| 66 | FES | 0.71708776 |
| 67 | CAMKK2 | 0.68969172 |
| 68 | RPS6KA5 | 0.67420445 |
| 69 | NME2 | 0.65102588 |
| 70 | IRAK1 | 0.60718126 |
| 71 | STK24 | 0.60199543 |
| 72 | PTK6 | 0.59367106 |
| 73 | MAP3K7 | 0.58252802 |
| 74 | CLK1 | 0.58038289 |
| 75 | HIPK2 | 0.57478951 |
| 76 | TYRO3 | 0.56934045 |
| 77 | PKN2 | 0.55741762 |
| 78 | MAPK7 | 0.53994393 |
| 79 | PDGFRB | 0.53810813 |
| 80 | CDK4 | 0.51977638 |
| 81 | RPS6KA1 | 0.49836142 |
| 82 | BMX | 0.49470422 |
| 83 | NTRK2 | 0.48873363 |
| 84 | MELK | 0.46246954 |
| 85 | STK4 | 0.46243283 |
| 86 | MAPKAPK2 | 0.44905421 |
| 87 | MAP2K6 | 0.44475324 |
| 88 | TRIB3 | 0.43165381 |
| 89 | ALK | 0.42755717 |
| 90 | CDK6 | 0.39786883 |
| 91 | CAMKK1 | 0.39756323 |
| 92 | ABL1 | 0.38633566 |
| 93 | PRKCH | 0.37772129 |
| 94 | ACVR1B | 0.36664857 |
| 95 | RPS6KC1 | 0.35727029 |
| 96 | RPS6KL1 | 0.35727029 |
| 97 | PKN1 | 0.34909495 |
| 98 | TESK2 | 0.34024428 |
| 99 | MATK | 0.33950075 |
| 100 | DAPK2 | 0.33736041 |
| 101 | MARK2 | 0.33700565 |
| 102 | TNK2 | 0.32610368 |
| 103 | BRD4 | 0.32573748 |
| 104 | CDK9 | 0.31547316 |
| 105 | MAPK15 | 0.30876840 |
| 106 | GSK3A | 0.30707434 |
| 107 | MAP3K11 | 0.30377124 |
| 108 | NEK9 | 0.30254067 |
| 109 | TRPM7 | 0.30198856 |
| 110 | PDK1 | 0.29993964 |
| 111 | TGFBR1 | 0.26645825 |
| 112 | RPS6KA6 | 0.25983720 |
| 113 | PDPK1 | 0.25925586 |
| 114 | MAP3K3 | 0.25371948 |
| 115 | MAPK11 | 0.24887689 |
| 116 | EGFR | 0.24824602 |
| 117 | PRKD2 | 0.24762577 |
| 118 | SIK1 | 0.24701167 |
| 119 | DYRK3 | 0.24638464 |
| 120 | MAPK3 | 0.24155311 |
| 121 | INSR | 0.23643701 |
| 122 | MAPK4 | 0.23189899 |
| 123 | RET | 0.22925403 |
| 124 | MAP3K8 | 0.22864031 |
| 125 | YES1 | 0.22498501 |
| 126 | MAPK12 | 0.20686546 |
| 127 | MAP3K5 | 0.20580452 |
| 128 | FYN | 0.19510816 |
| 129 | TTN | 0.19276879 |
| 130 | STK11 | 0.19201249 |
| 131 | PRKCD | 0.18667951 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.64723815 |
| 2 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 3.42016131 |
| 3 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 3.25703338 |
| 4 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.80460312 |
| 5 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.74624742 |
| 6 | Leishmaniasis_Homo sapiens_hsa05140 | 2.72677287 |
| 7 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 2.68069725 |
| 8 | Measles_Homo sapiens_hsa05162 | 2.63433441 |
| 9 | Allograft rejection_Homo sapiens_hsa05330 | 2.55803946 |
| 10 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.43073888 |
| 11 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.30258315 |
| 12 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.22778147 |
| 13 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.19446048 |
| 14 | TNF signaling pathway_Homo sapiens_hsa04668 | 2.06451878 |
| 15 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 2.05408747 |
| 16 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.01350053 |
| 17 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.98114914 |
| 18 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.95576477 |
| 19 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.83763725 |
| 20 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.78087430 |
| 21 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.76848377 |
| 22 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.76184054 |
| 23 | Legionellosis_Homo sapiens_hsa05134 | 1.73902347 |
| 24 | Influenza A_Homo sapiens_hsa05164 | 1.62392357 |
| 25 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.58478355 |
| 26 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.57821326 |
| 27 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.53878621 |
| 28 | Apoptosis_Homo sapiens_hsa04210 | 1.51993355 |
| 29 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.44123365 |
| 30 | Hepatitis B_Homo sapiens_hsa05161 | 1.43879808 |
| 31 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.41777736 |
| 32 | Tuberculosis_Homo sapiens_hsa05152 | 1.30602724 |
| 33 | Shigellosis_Homo sapiens_hsa05131 | 1.29037532 |
| 34 | Viral myocarditis_Homo sapiens_hsa05416 | 1.28783013 |
| 35 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.28278787 |
| 36 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 1.26876500 |
| 37 | Pertussis_Homo sapiens_hsa05133 | 1.24435972 |
| 38 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.22646206 |
| 39 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.20730837 |
| 40 | Malaria_Homo sapiens_hsa05144 | 1.20289814 |
| 41 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.20264116 |
| 42 | Asthma_Homo sapiens_hsa05310 | 1.18033799 |
| 43 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.16020947 |
| 44 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.15859834 |
| 45 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.12021614 |
| 46 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.04048051 |
| 47 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.02114256 |
| 48 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.01819674 |
| 49 | Hepatitis C_Homo sapiens_hsa05160 | 0.99798700 |
| 50 | Salmonella infection_Homo sapiens_hsa05132 | 0.97256491 |
| 51 | HTLV-I infection_Homo sapiens_hsa05166 | 0.96937267 |
| 52 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.91902792 |
| 53 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.91606411 |
| 54 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.88460511 |
| 55 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.85549264 |
| 56 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.83719477 |
| 57 | Platelet activation_Homo sapiens_hsa04611 | 0.80934955 |
| 58 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.79020536 |
| 59 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.77193434 |
| 60 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.73469284 |
| 61 | Prion diseases_Homo sapiens_hsa05020 | 0.68582957 |
| 62 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.66837941 |
| 63 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.65312112 |
| 64 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.65111685 |
| 65 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.61161024 |
| 66 | Colorectal cancer_Homo sapiens_hsa05210 | 0.61136133 |
| 67 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.60999790 |
| 68 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.58228093 |
| 69 | Circadian rhythm_Homo sapiens_hsa04710 | 0.57260730 |
| 70 | Insulin resistance_Homo sapiens_hsa04931 | 0.53881630 |
| 71 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.51693720 |
| 72 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.49831715 |
| 73 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.49524761 |
| 74 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.49460506 |
| 75 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.48658680 |
| 76 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.46693306 |
| 77 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.45147298 |
| 78 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.43135943 |
| 79 | Bladder cancer_Homo sapiens_hsa05219 | 0.42479299 |
| 80 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.41910827 |
| 81 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.41218088 |
| 82 | Endocytosis_Homo sapiens_hsa04144 | 0.38963367 |
| 83 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.38693700 |
| 84 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.38542154 |
| 85 | Prostate cancer_Homo sapiens_hsa05215 | 0.37694513 |
| 86 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.35149192 |
| 87 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.33781025 |
| 88 | Amoebiasis_Homo sapiens_hsa05146 | 0.33744324 |
| 89 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.31763495 |
| 90 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.30736928 |
| 91 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.29252231 |
| 92 | Pathways in cancer_Homo sapiens_hsa05200 | 0.28870310 |
| 93 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.28656398 |
| 94 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.28104967 |
| 95 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.27778047 |
| 96 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.25776465 |
| 97 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.25389054 |
| 98 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.24073629 |
| 99 | Lysosome_Homo sapiens_hsa04142 | 0.23540975 |
| 100 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.23441449 |
| 101 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.23135019 |
| 102 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.22714318 |
| 103 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.21517713 |
| 104 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.21318456 |
| 105 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.20994619 |
| 106 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.20259361 |
| 107 | Endometrial cancer_Homo sapiens_hsa05213 | 0.19867361 |
| 108 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.18931194 |
| 109 | Other glycan degradation_Homo sapiens_hsa00511 | 0.18031766 |
| 110 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.18022962 |
| 111 | Ribosome_Homo sapiens_hsa03010 | 0.16806718 |
| 112 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.16446201 |
| 113 | Phagosome_Homo sapiens_hsa04145 | 0.14856442 |
| 114 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.13165531 |
| 115 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.10966206 |
| 116 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.09639000 |
| 117 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.07584919 |

