GPR135

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K11-linked deubiquitination (GO:0035871)9.74938203
2negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)9.64850600
3negative regulation of T-helper cell differentiation (GO:0045623)9.64850600
4regulation of T-helper 2 cell differentiation (GO:0045628)9.04937585
5positive regulation of RNA splicing (GO:0033120)8.76981596
6negative regulation of type 2 immune response (GO:0002829)8.68953814
7regulation of T-helper 1 cell differentiation (GO:0045625)8.43730981
8detection of chemical stimulus involved in sensory perception (GO:0050907)7.95565226
9cAMP biosynthetic process (GO:0006171)7.71698390
10negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)7.56634065
11negative regulation of alpha-beta T cell differentiation (GO:0046639)7.16809108
12enteric nervous system development (GO:0048484)6.98329022
13cilium or flagellum-dependent cell motility (GO:0001539)6.82874385
14righting reflex (GO:0060013)6.79031711
15positive regulation of mitochondrial fission (GO:0090141)6.78933341
16synaptic transmission, dopaminergic (GO:0001963)6.70282734
17regulation of protein sumoylation (GO:0033233)6.56459939
18regulation of short-term neuronal synaptic plasticity (GO:0048172)5.80801942
19detection of chemical stimulus (GO:0009593)5.70794740
20heterotypic cell-cell adhesion (GO:0034113)5.57182231
21axonemal dynein complex assembly (GO:0070286)5.56171653
22arachidonic acid secretion (GO:0050482)5.55658519
23icosanoid secretion (GO:0032309)5.55658519
24positive regulation of T-helper 1 type immune response (GO:0002827)5.29231439
25positive regulation of T-helper cell differentiation (GO:0045624)5.15458333
26endothelial cell differentiation (GO:0045446)5.11429495
27synaptic vesicle exocytosis (GO:0016079)5.05633195
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.02652004
29hepatocyte apoptotic process (GO:0097284)5.00584560
30nephron epithelium morphogenesis (GO:0072088)4.96709485
31nephron tubule morphogenesis (GO:0072078)4.96709485
32vocalization behavior (GO:0071625)4.96142624
33chemosensory behavior (GO:0007635)4.92129641
34synaptic vesicle maturation (GO:0016188)4.88350008
35regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.87927053
36neuronal ion channel clustering (GO:0045161)4.82591502
37drug transmembrane transport (GO:0006855)4.81458614
38glutamate secretion (GO:0014047)4.79611123
39protein localization to synapse (GO:0035418)4.77714332
40regulation of mitochondrial fission (GO:0090140)4.75976551
41regulation of synaptic vesicle exocytosis (GO:2000300)4.71924227
42positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.71118955
43neural tube formation (GO:0001841)4.68884114
44retina layer formation (GO:0010842)4.66761204
45locomotory exploration behavior (GO:0035641)4.62809181
46neuron cell-cell adhesion (GO:0007158)4.59848113
47phosphatidylinositol acyl-chain remodeling (GO:0036149)4.58338797
48fatty acid derivative transport (GO:1901571)4.55588115
49icosanoid transport (GO:0071715)4.55588115
50regulation of glutamate receptor signaling pathway (GO:1900449)4.40552018
51neurotransmitter secretion (GO:0007269)4.37898355
52synaptic vesicle docking involved in exocytosis (GO:0016081)4.34043625
53embryonic digestive tract morphogenesis (GO:0048557)4.26351482
54hyaluronan catabolic process (GO:0030214)4.24561425
55left/right axis specification (GO:0070986)4.19481370
56phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.17605392
57phosphatidylserine acyl-chain remodeling (GO:0036150)4.14684448
58regulation of synaptic vesicle transport (GO:1902803)4.09907637
59exploration behavior (GO:0035640)4.04942165
60neurotransmitter-gated ion channel clustering (GO:0072578)4.03443999
61cilium movement (GO:0003341)4.02050693
62ionotropic glutamate receptor signaling pathway (GO:0035235)4.00839512
63dendritic spine organization (GO:0097061)4.00569579
64negative regulation of cytosolic calcium ion concentration (GO:0051481)3.95987271
65cAMP metabolic process (GO:0046058)3.88942227
66cellular zinc ion homeostasis (GO:0006882)3.88885569
67cyclic purine nucleotide metabolic process (GO:0052652)3.87450608
68regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.87213299
69regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.86113297
70glutamate receptor signaling pathway (GO:0007215)3.85335955
71regulation of glutamate secretion (GO:0014048)3.84939253
72mitochondrial fusion (GO:0008053)3.83832044
73regulation of neuronal synaptic plasticity (GO:0048168)3.82794530
74attachment of spindle microtubules to kinetochore (GO:0008608)3.82774237
75neuron-neuron synaptic transmission (GO:0007270)3.81505418
76negative regulation of amino acid transport (GO:0051956)3.77856915
77synaptic transmission, glutamatergic (GO:0035249)3.77574308
78negative regulation of alpha-beta T cell activation (GO:0046636)3.77177189
79neuronal action potential propagation (GO:0019227)3.71446747
80cyclic nucleotide biosynthetic process (GO:0009190)3.71255952
81water transport (GO:0006833)3.69282131
82gamma-aminobutyric acid transport (GO:0015812)3.68324376
83regulation of long-term neuronal synaptic plasticity (GO:0048169)3.66828180
84proline transport (GO:0015824)3.66787894
85regulation of T-helper 1 type immune response (GO:0002825)3.66765878
86cellular response to glucagon stimulus (GO:0071377)3.65092817
87positive regulation of protein targeting to membrane (GO:0090314)3.65069433
88response to dietary excess (GO:0002021)3.64869413
89renal tubule morphogenesis (GO:0061333)3.64143125
90regulation of cAMP-mediated signaling (GO:0043949)3.61599674
91mating behavior (GO:0007617)3.61548487
92single fertilization (GO:0007338)3.61434867
93long-term synaptic potentiation (GO:0060291)3.61388429
94neurofilament cytoskeleton organization (GO:0060052)3.59270544
95positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.57704294
96cytoskeletal anchoring at plasma membrane (GO:0007016)3.57550206
97positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.57051726
98regulation of T-helper cell differentiation (GO:0045622)3.57018093
99cerebellar granule cell differentiation (GO:0021707)3.54020887
100ATP hydrolysis coupled proton transport (GO:0015991)3.53493189
101energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.53493189
102positive regulation of synapse maturation (GO:0090129)3.52965806
103regulation of excitatory postsynaptic membrane potential (GO:0060079)3.45927830
104regulation of postsynaptic membrane potential (GO:0060078)3.45674771
105neurotransmitter transport (GO:0006836)3.44868399
106layer formation in cerebral cortex (GO:0021819)3.42753083
107membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.42406963
108regulation of type 2 immune response (GO:0002828)3.40607639
109positive regulation of steroid hormone secretion (GO:2000833)3.39968931
110negative regulation of actin filament bundle assembly (GO:0032232)3.37943846
111innervation (GO:0060384)3.36781794
112negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35579040
113behavioral fear response (GO:0001662)3.34537285
114behavioral defense response (GO:0002209)3.34537285
115fear response (GO:0042596)3.34260840
116regulation of synaptic transmission, glutamatergic (GO:0051966)3.33111481
117positive regulation of membrane potential (GO:0045838)3.32676252
118regulation of synaptic plasticity (GO:0048167)3.31799770
119postsynaptic membrane organization (GO:0001941)3.29795814
120neuron recognition (GO:0008038)3.29749878
121monoamine transport (GO:0015844)3.29726801
122behavioral response to cocaine (GO:0048148)3.28927273
123mitochondrial fission (GO:0000266)3.28921299
124regulation of synapse structural plasticity (GO:0051823)3.28049326
125fluid transport (GO:0042044)3.27425882
126dendritic spine morphogenesis (GO:0060997)3.26386504
127cell migration in hindbrain (GO:0021535)3.25706369
128negative regulation of astrocyte differentiation (GO:0048712)3.25650879
129activation of protein kinase A activity (GO:0034199)3.24055371
130presynaptic membrane assembly (GO:0097105)3.22799303
131regulation of neurotransmitter levels (GO:0001505)3.22211761
132cellular response to ATP (GO:0071318)3.20577143
133drug transport (GO:0015893)3.20508166
134synaptic vesicle endocytosis (GO:0048488)3.18929172
135negative regulation of T cell differentiation (GO:0045581)3.17771721
136regulation of neurotransmitter secretion (GO:0046928)3.16208450
137G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.15930972
138striatum development (GO:0021756)3.15366469
139gamma-aminobutyric acid signaling pathway (GO:0007214)3.14083742
140sequestering of metal ion (GO:0051238)3.13973130
141neuromuscular process controlling balance (GO:0050885)3.13260481
142regulation of dendritic spine morphogenesis (GO:0061001)3.12390347
143positive regulation of dendritic spine development (GO:0060999)3.12319717
144cellular potassium ion homeostasis (GO:0030007)3.12006999
145membrane hyperpolarization (GO:0060081)3.11308134
146regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.10815230
147positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.10743767
148pre-miRNA processing (GO:0031054)3.09714352
149regulation of corticosteroid hormone secretion (GO:2000846)3.09624867
150transmission of nerve impulse (GO:0019226)3.08324419
151long-term memory (GO:0007616)3.06699604
152female mating behavior (GO:0060180)3.06298723
153regulation of vesicle fusion (GO:0031338)3.04897708
154cerebellar Purkinje cell differentiation (GO:0021702)3.04818919
155presynaptic membrane organization (GO:0097090)3.04624574
156pyrimidine nucleobase catabolic process (GO:0006208)3.04560389
157prepulse inhibition (GO:0060134)3.02701125
158positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.02422769
159reflex (GO:0060004)3.02141955
160positive regulation of synaptic transmission (GO:0050806)3.01825608
161positive regulation of synaptic transmission, GABAergic (GO:0032230)3.01271770
162sulfur amino acid catabolic process (GO:0000098)3.01228761
163positive regulation of neurotransmitter secretion (GO:0001956)3.00178406
164negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.99763007
165positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.99270946
166regulation of female receptivity (GO:0045924)2.98955705
167leukotriene biosynthetic process (GO:0019370)2.98860659
168regulation of neurotransmitter transport (GO:0051588)2.98620099
169zinc ion homeostasis (GO:0055069)2.97554061
170neuromuscular process controlling posture (GO:0050884)2.95868493
171phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.94964791
172axonal fasciculation (GO:0007413)2.94004738
173detection of light stimulus involved in sensory perception (GO:0050962)2.93801061
174detection of light stimulus involved in visual perception (GO:0050908)2.93801061
175sodium ion export (GO:0071436)2.93714179
176synapse assembly (GO:0007416)2.92595066
177adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)2.92222546
178membrane depolarization during action potential (GO:0086010)2.91643793
179membrane depolarization (GO:0051899)2.90556523
180learning (GO:0007612)2.89628522
181positive regulation of neurotransmitter transport (GO:0051590)2.88432319
182regulation of voltage-gated calcium channel activity (GO:1901385)2.84025890
183auditory behavior (GO:0031223)2.83270467
184regulation of synaptic transmission (GO:0050804)2.83226442
185cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.82908306
186synaptic transmission (GO:0007268)2.81878243
187negative regulation of dendrite morphogenesis (GO:0050774)2.81128981
188negative regulation of microtubule polymerization (GO:0031115)2.80253353
189regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.80061900
190regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.80061900
191tooth mineralization (GO:0034505)13.2733063
192detection of chemical stimulus involved in sensory perception of smell (GO:0050911)12.6051037
193positive regulation of protein sumoylation (GO:0033235)10.6452671
194seminiferous tubule development (GO:0072520)10.0879077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse8.18885503
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.22460767
3EZH2_22144423_ChIP-Seq_EOC_Human4.81472177
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.17062036
5IGF1R_20145208_ChIP-Seq_DFB_Human4.12457009
6GBX2_23144817_ChIP-Seq_PC3_Human3.62856232
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21296683
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.14823638
9JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01428300
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72745108
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72745108
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.70897571
13REST_21632747_ChIP-Seq_MESCs_Mouse2.69996978
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64712420
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.63995963
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.63059215
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62620072
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54395852
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53849082
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49595339
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.47243929
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.43670817
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.42585886
24DROSHA_22980978_ChIP-Seq_HELA_Human2.33715012
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.30822995
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23230062
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.15951677
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.11315586
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.05632232
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93600572
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91892247
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.90029255
33ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.88898369
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.85670222
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83617647
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78300690
37* AR_21572438_ChIP-Seq_LNCaP_Human1.75553133
38TAF15_26573619_Chip-Seq_HEK293_Human1.73824309
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67754604
40* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66658946
41SMAD4_21799915_ChIP-Seq_A2780_Human1.65360182
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.53740050
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46760020
44CBP_20019798_ChIP-Seq_JUKART_Human1.46537750
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46537750
46YY1_22570637_ChIP-Seq_MALME-3M_Human1.44206664
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.43820225
48* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43194343
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42644576
50TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39328423
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37846767
52RXR_22108803_ChIP-Seq_LS180_Human1.37471708
53* P300_19829295_ChIP-Seq_ESCs_Human1.33437173
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33381086
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33235241
56TBL1_22424771_ChIP-Seq_293T_Human1.33055550
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32936196
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31969041
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.31509592
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30466860
61GATA1_19941826_ChIP-Seq_K562_Human1.30131313
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30012425
63RING1B_27294783_Chip-Seq_ESCs_Mouse1.29027251
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27857086
65FUS_26573619_Chip-Seq_HEK293_Human1.27000051
66HNFA_21074721_ChIP-Seq_CACO-2_Human1.26677855
67RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24560406
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24340646
69AR_19668381_ChIP-Seq_PC3_Human1.24090907
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.23427748
71AR_25329375_ChIP-Seq_VCAP_Human1.22694434
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22595163
73CJUN_26792858_Chip-Seq_BT549_Human1.22452933
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21969572
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21572720
76* ER_23166858_ChIP-Seq_MCF-7_Human1.17468891
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.15136539
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14521504
79TP53_18474530_ChIP-ChIP_U2OS_Human1.14199580
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13896977
81PHF8_20622853_ChIP-Seq_HELA_Human1.12654815
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12539112
83ZNF274_21170338_ChIP-Seq_K562_Hela1.11467697
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11220454
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10956100
86* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10905031
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10021601
88STAT3_23295773_ChIP-Seq_U87_Human1.09894538
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09178234
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08584525
91CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.07478330
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07113362
93* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.06697716
94* RING1B_27294783_Chip-Seq_NPCs_Mouse1.06626820
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06510069
96NFYB_21822215_ChIP-Seq_K562_Human1.06451819
97RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05550829
98PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.04552593
99BCAT_22108803_ChIP-Seq_LS180_Human1.04076747
100EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03958642
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03917109
102AHR_22903824_ChIP-Seq_MCF-7_Human1.03705865
103GATA6_21074721_ChIP-Seq_CACO-2_Human1.03667382
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.03605220
105SOX2_18555785_Chip-Seq_ESCs_Mouse1.03351754
106EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03338263
107RNF2_27304074_Chip-Seq_NSC_Mouse1.02180706
108ARNT_22903824_ChIP-Seq_MCF-7_Human1.01257951
109P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00686584
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00403670
111ETV1_20927104_ChIP-Seq_GIST48_Human1.00011053
112E2F1_18555785_Chip-Seq_ESCs_Mouse0.98610650
113BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98139818
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97675814
115EZH2_27294783_Chip-Seq_NPCs_Mouse0.97593235
116TCF4_22108803_ChIP-Seq_LS180_Human0.97282437
117KDM2B_26808549_Chip-Seq_K562_Human0.97026896
118SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96182575
119CMYC_18555785_Chip-Seq_ESCs_Mouse0.95956541
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95895911
121SMAD4_21741376_ChIP-Seq_HESCs_Human0.95763966
122YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95739174
123ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95015642
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94835090
125CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94239551
126VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93891107
127EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93482735
128SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92605019
129* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92332132
130TP53_16413492_ChIP-PET_HCT116_Human0.91489666
131* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90854300
132* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90854300
133TCF4_23295773_ChIP-Seq_U87_Human0.90431264
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.89676378
135SMAD3_21741376_ChIP-Seq_ESCs_Human0.89620720
136TP53_20018659_ChIP-ChIP_R1E_Mouse0.88882136
137RUNX2_22187159_ChIP-Seq_PCA_Human0.87156328
138JUN_21703547_ChIP-Seq_K562_Human0.86923487
139CTCF_27219007_Chip-Seq_Bcells_Human0.86835298
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84800167
141NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84553616
142TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83935389
143UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83826755
144* PRDM14_20953172_ChIP-Seq_ESCs_Human0.83692453
145POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83405978
146* SMAD4_21741376_ChIP-Seq_EPCs_Human0.82999088
147VDR_22108803_ChIP-Seq_LS180_Human0.81793138

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.81227774
2MP0003880_abnormal_central_pattern4.22904905
3MP0003635_abnormal_synaptic_transmissio3.92310659
4MP0004270_analgesia3.41040419
5MP0003252_abnormal_bile_duct3.40084418
6MP0002822_catalepsy3.33844955
7MP0009046_muscle_twitch3.30531705
8MP0009745_abnormal_behavioral_response3.29155718
9MP0002063_abnormal_learning/memory/cond3.17516699
10MP0004264_abnormal_extraembryonic_tissu3.14967689
11MP0001968_abnormal_touch/_nociception3.09466842
12MP0002064_seizures2.99674019
13MP0002928_abnormal_bile_duct2.95183493
14MP0005423_abnormal_somatic_nervous2.93540000
15MP0004133_heterotaxia2.77071306
16MP0002572_abnormal_emotion/affect_behav2.64020179
17MP0002272_abnormal_nervous_system2.53551653
18MP0002736_abnormal_nociception_after2.43633417
19MP0002734_abnormal_mechanical_nocicepti2.41835438
20MP0002735_abnormal_chemical_nociception2.28049798
21MP0001440_abnormal_grooming_behavior2.25274741
22MP0003329_amyloid_beta_deposits2.24277385
23MP0004272_abnormal_basement_membrane2.18619544
24MP0005408_hypopigmentation2.16924576
25MP0001486_abnormal_startle_reflex2.15303372
26MP0006276_abnormal_autonomic_nervous2.14467836
27MP0001501_abnormal_sleep_pattern2.13191715
28MP0001270_distended_abdomen2.08085668
29MP0002751_abnormal_autonomic_nervous2.04208577
30MP0002733_abnormal_thermal_nociception2.03069655
31MP0002067_abnormal_sensory_capabilities2.01520818
32MP0009780_abnormal_chondrocyte_physiolo2.01049503
33MP0005084_abnormal_gallbladder_morpholo11.4328297
34MP0005410_abnormal_fertilization1.97295306
35MP0004858_abnormal_nervous_system1.95904513
36MP0001970_abnormal_pain_threshold1.85873371
37MP0002184_abnormal_innervation1.80772845
38MP0005379_endocrine/exocrine_gland_phen1.74181334
39MP0003718_maternal_effect1.70868066
40MP0004924_abnormal_behavior1.68256068
41MP0005386_behavior/neurological_phenoty1.68256068
42MP0005220_abnormal_exocrine_pancreas1.62654007
43MP0003943_abnormal_hepatobiliary_system1.61638395
44MP0008569_lethality_at_weaning1.61056696
45MP0002557_abnormal_social/conspecific_i1.60099323
46MP0000778_abnormal_nervous_system1.59581027
47MP0000955_abnormal_spinal_cord1.57065889
48MP0004811_abnormal_neuron_physiology1.54458413
49MP0001529_abnormal_vocalization1.50209145
50MP0002837_dystrophic_cardiac_calcinosis1.46802289
51MP0004142_abnormal_muscle_tone1.41362120
52MP0003122_maternal_imprinting1.39786922
53MP0002066_abnormal_motor_capabilities/c1.36362041
54MP0002882_abnormal_neuron_morphology1.33503954
55MP0002909_abnormal_adrenal_gland1.29401058
56MP0001905_abnormal_dopamine_level1.27277436
57MP0002638_abnormal_pupillary_reflex1.26942457
58MP0003879_abnormal_hair_cell1.26940166
59MP0002653_abnormal_ependyma_morphology1.23521320
60MP0001958_emphysema1.23288998
61MP0005253_abnormal_eye_physiology1.23088183
62MP0003633_abnormal_nervous_system1.21930173
63MP0008872_abnormal_physiological_respon1.21099664
64MP0004885_abnormal_endolymph1.20888004
65MP0003787_abnormal_imprinting1.20805673
66MP0005646_abnormal_pituitary_gland1.20172043
67MP0001984_abnormal_olfaction1.18880608
68MP0005551_abnormal_eye_electrophysiolog1.18655023
69MP0003878_abnormal_ear_physiology1.17391747
70MP0005377_hearing/vestibular/ear_phenot1.17391747
71MP0008961_abnormal_basal_metabolism1.16453340
72MP0000013_abnormal_adipose_tissue1.15584574
73MP0000604_amyloidosis1.15583667
74MP0005535_abnormal_body_temperature1.12300067
75MP0000751_myopathy1.09576468
76MP0005165_increased_susceptibility_to1.07914441
77MP0005623_abnormal_meninges_morphology1.06433942
78MP0003631_nervous_system_phenotype1.05448159
79MP0002069_abnormal_eating/drinking_beha1.03704916
80MP0001944_abnormal_pancreas_morphology1.03461509
81MP0002152_abnormal_brain_morphology1.02981972
82MP0003698_abnormal_male_reproductive1.01208114
83MP0001502_abnormal_circadian_rhythm1.01036875
84MP0003121_genomic_imprinting0.98759988
85MP0002229_neurodegeneration0.98144766
86MP0004085_abnormal_heartbeat0.96188273
87MP0001299_abnormal_eye_distance/0.95418036
88MP0004145_abnormal_muscle_electrophysio0.94597934
89MP0001986_abnormal_taste_sensitivity0.94362108
90MP0001188_hyperpigmentation0.88540755
91MP0000371_diluted_coat_color0.87500201
92MP0009764_decreased_sensitivity_to0.87143889
93MP0008874_decreased_physiological_sensi0.84085950
94MP0000470_abnormal_stomach_morphology0.83994159
95MP0001929_abnormal_gametogenesis0.83313318
96MP0003632_abnormal_nervous_system0.80676514
97MP0002090_abnormal_vision0.79932831
98MP0004130_abnormal_muscle_cell0.79418918
99MP0003137_abnormal_impulse_conducting0.79011622
100MP0005164_abnormal_response_to0.76142272
101MP0002752_abnormal_somatic_nervous0.76000998
102MP0005360_urolithiasis0.75421885
103MP0008875_abnormal_xenobiotic_pharmacok0.74335442
104MP0002161_abnormal_fertility/fecundity0.73128222
105MP0003634_abnormal_glial_cell0.72792418
106MP0005085_abnormal_gallbladder_physiolo0.72318582
107MP0005395_other_phenotype0.71978489
108MP0006072_abnormal_retinal_apoptosis0.71946352
109MP0005187_abnormal_penis_morphology0.71430495
110MP0005499_abnormal_olfactory_system0.70651322
111MP0005394_taste/olfaction_phenotype0.70651322
112MP0003690_abnormal_glial_cell0.68511314
113MP0001963_abnormal_hearing_physiology0.68324385
114MP0004742_abnormal_vestibular_system0.67567717
115MP0004215_abnormal_myocardial_fiber0.67279688
116MP0005503_abnormal_tendon_morphology0.67174937
117MP0003638_abnormal_response/metabolism_0.66018030
118MP0005448_abnormal_energy_balance0.65324217
119MP0001177_atelectasis0.65278599
120MP0002876_abnormal_thyroid_physiology0.64789315
121MP0001664_abnormal_digestion0.62241009
122MP0001915_intracranial_hemorrhage0.61968964
123MP0004043_abnormal_pH_regulation0.61800331
124MP0003283_abnormal_digestive_organ0.60835994
125MP0004233_abnormal_muscle_weight0.59329576
126MP0003953_abnormal_hormone_level0.59200174
127MP0000569_abnormal_digit_pigmentation0.57711839
128MP0001348_abnormal_lacrimal_gland0.57309152
129MP0005645_abnormal_hypothalamus_physiol0.56926438
130MP0006035_abnormal_mitochondrial_morpho0.55211949
131MP0002078_abnormal_glucose_homeostasis0.54892747
132MP0005083_abnormal_biliary_tract0.54493490
133MP0003075_altered_response_to0.54070158
134MP0001943_abnormal_respiration0.53980843
135MP0000609_abnormal_liver_physiology0.51918755
136MP0010386_abnormal_urinary_bladder0.51695002
137MP0002693_abnormal_pancreas_physiology0.51674471
138MP0009053_abnormal_anal_canal0.51238363
139MP0000631_abnormal_neuroendocrine_gland0.50972420
140MP0004036_abnormal_muscle_relaxation0.50768408
141MP0002136_abnormal_kidney_physiology0.50685382
142MP0005391_vision/eye_phenotype0.49148260
143MP0005670_abnormal_white_adipose0.49085988
144MP0002102_abnormal_ear_morphology0.44751727
145MP0001851_eye_inflammation0.44483830
146MP0002234_abnormal_pharynx_morphology0.43574175
147MP0000639_abnormal_adrenal_gland0.42358244
148MP0004019_abnormal_vitamin_homeostasis0.41798719
149MP0005332_abnormal_amino_acid0.41448784
150MP0002210_abnormal_sex_determination0.41190031
151MP0000465_gastrointestinal_hemorrhage0.40590391
152MP0005195_abnormal_posterior_eye0.40360484
153MP0005334_abnormal_fat_pad0.36529911
154MP0002098_abnormal_vibrissa_morphology0.34914182
155MP0002249_abnormal_larynx_morphology0.34455630

Predicted human phenotypes

RankGene SetZ-score
1Amelogenesis imperfecta (HP:0000705)9.88458507
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.08873227
3Abnormality of calcium-phosphate metabolism (HP:0100530)7.54417018
4Osteomalacia (HP:0002749)7.39620859
5Abnormality of dental color (HP:0011073)6.83981782
6Abnormality of renal resorption (HP:0011038)6.62696851
7Polyuria (HP:0000103)6.46565399
8Focal motor seizures (HP:0011153)6.25940472
9Myokymia (HP:0002411)6.22720685
10Abnormality of the dental pulp (HP:0006479)6.17772920
11Abnormal respiratory motile cilium physiology (HP:0012261)5.91881520
12Abnormal urine output (HP:0012590)5.67254572
13Chronic bronchitis (HP:0004469)5.55925788
14Rhinitis (HP:0012384)5.48319808
15Focal seizures (HP:0007359)5.00520419
16Abnormality of renal excretion (HP:0011036)4.98439418
17Visual hallucinations (HP:0002367)4.83985624
18Volvulus (HP:0002580)4.58034084
19Progressive cerebellar ataxia (HP:0002073)4.45056146
20Abnormality of midbrain morphology (HP:0002418)4.38586861
21Molar tooth sign on MRI (HP:0002419)4.38586861
22Dynein arm defect of respiratory motile cilia (HP:0012255)4.03474327
23Absent/shortened dynein arms (HP:0200106)4.03474327
24Atonic seizures (HP:0010819)3.94923051
25Nephronophthisis (HP:0000090)3.94600076
26Epileptic encephalopathy (HP:0200134)3.93419069
27Round ear (HP:0100830)3.91892337
28Hyperventilation (HP:0002883)3.70827819
29Action tremor (HP:0002345)3.65996456
30Absence seizures (HP:0002121)3.65917671
31Lip pit (HP:0100267)3.55459518
32Abnormal respiratory motile cilium morphology (HP:0005938)3.45610677
33Abnormal respiratory epithelium morphology (HP:0012253)3.45610677
34Generalized tonic-clonic seizures (HP:0002069)3.34638111
35Dialeptic seizures (HP:0011146)3.30370442
36Febrile seizures (HP:0002373)3.28707582
37Nephrocalcinosis (HP:0000121)3.28211753
38Gaze-evoked nystagmus (HP:0000640)3.13293850
39Dysdiadochokinesis (HP:0002075)3.11814526
40Tachypnea (HP:0002789)3.11109000
41Poor eye contact (HP:0000817)3.08385089
42Abnormality of the renal medulla (HP:0100957)3.05635017
43Supranuclear gaze palsy (HP:0000605)3.04573959
44Toxemia of pregnancy (HP:0100603)3.03168956
45Impaired vibration sensation in the lower limbs (HP:0002166)2.95937332
46Amblyopia (HP:0000646)2.95242500
47Depression (HP:0000716)2.95159433
48Abnormality of the lower motor neuron (HP:0002366)2.94239069
49Impaired social interactions (HP:0000735)2.92289131
50Abnormal social behavior (HP:0012433)2.92289131
51Anxiety (HP:0000739)2.86116450
52Esophageal varix (HP:0002040)2.85583453
53Broad-based gait (HP:0002136)2.84181549
54Abnormal eating behavior (HP:0100738)2.81729835
55Insidious onset (HP:0003587)2.80846647
56Termporal pattern (HP:0011008)2.80846647
57Bronchiectasis (HP:0002110)2.80300324
58Annular pancreas (HP:0001734)2.78904242
59Truncal ataxia (HP:0002078)2.78292813
60Cerebral inclusion bodies (HP:0100314)2.75991149
61Dysmetria (HP:0001310)2.75732774
62Pheochromocytoma (HP:0002666)2.73747009
63Torticollis (HP:0000473)2.72325916
64Focal dystonia (HP:0004373)2.66482052
65Depressed nasal tip (HP:0000437)2.66358815
66Stage 5 chronic kidney disease (HP:0003774)2.60403454
67Dysmetric saccades (HP:0000641)2.60134900
68Large earlobe (HP:0009748)2.59937954
69Lipoatrophy (HP:0100578)2.55182586
70IgM deficiency (HP:0002850)2.55045857
71Postural instability (HP:0002172)2.54177431
72Sparse lateral eyebrow (HP:0005338)2.53404282
73Excessive salivation (HP:0003781)2.50905431
74Drooling (HP:0002307)2.50905431
75Progressive inability to walk (HP:0002505)2.47953432
76Urinary bladder sphincter dysfunction (HP:0002839)2.47837150
77Hypoparathyroidism (HP:0000829)2.46606506
78Epileptiform EEG discharges (HP:0011182)2.45438248
79Thick eyebrow (HP:0000574)2.45014687
80Scanning speech (HP:0002168)2.44644713
81Genetic anticipation (HP:0003743)2.43297623
82Neuroendocrine neoplasm (HP:0100634)2.43281045
83Craniofacial dystonia (HP:0012179)2.42263790
84Hemiparesis (HP:0001269)2.41585784
85Hypoventilation (HP:0002791)2.41281252
86Tubulointerstitial nephritis (HP:0001970)2.39410040
87EEG with generalized epileptiform discharges (HP:0011198)2.37213268
88Autoimmune thrombocytopenia (HP:0001973)2.36962130
89Ankle clonus (HP:0011448)2.36598525
90Status epilepticus (HP:0002133)2.36514015
91Abnormality of the corticospinal tract (HP:0002492)2.35292284
92Mutism (HP:0002300)2.35249805
93Urinary urgency (HP:0000012)2.33141604
94Hypsarrhythmia (HP:0002521)2.26884799
95Short 5th finger (HP:0009237)2.24851443
96Neurofibrillary tangles (HP:0002185)2.24526431
97Delusions (HP:0000746)2.24044648
98Bronchitis (HP:0012387)2.22665505
99Bradykinesia (HP:0002067)2.20906650
100Intestinal fistula (HP:0100819)2.19810705
101Chronic hepatic failure (HP:0100626)2.16290398
102Recurrent otitis media (HP:0000403)2.16117866
103Stereotypic behavior (HP:0000733)2.15424633
104Personality changes (HP:0000751)2.14882322
105Spastic gait (HP:0002064)2.13110576
106Agitation (HP:0000713)2.12769684
107Abnormal gallbladder physiology (HP:0012438)2.12451620
108Cholecystitis (HP:0001082)2.12451620
109Failure to thrive in infancy (HP:0001531)2.10937469
110Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.09033214
111Impaired vibratory sensation (HP:0002495)2.07225827
112Hyperphosphaturia (HP:0003109)2.05710154
113Truncal obesity (HP:0001956)2.05333276
114Hemiplegia (HP:0002301)2.01789238
115Diplopia (HP:0000651)2.00565101
116Abnormality of binocular vision (HP:0011514)2.00565101
117Gait ataxia (HP:0002066)2.00040555
118Overgrowth (HP:0001548)10.0035750
119Intention tremor (HP:0002080)1.99232106
120Limb dystonia (HP:0002451)1.98768504
121Nephropathy (HP:0000112)1.98473288
122Abnormality of urine glucose concentration (HP:0011016)1.98137830
123Glycosuria (HP:0003076)1.98137830
124Polyphagia (HP:0002591)1.97208457
125Inability to walk (HP:0002540)1.96371253
126Oligomenorrhea (HP:0000876)1.94293629
127Chorioretinal coloboma (HP:0000567)1.93991863
128Postural tremor (HP:0002174)1.93085812
129Impaired smooth pursuit (HP:0007772)1.92950323
130Impaired pain sensation (HP:0007328)1.92663787
131Abnormality of pain sensation (HP:0010832)1.92663787
132Hepatitis (HP:0012115)1.91392538
133Periauricular skin pits (HP:0100277)1.90983801
134Preauricular pit (HP:0004467)1.90983801
135Lower limb muscle weakness (HP:0007340)1.89134297
136Striae distensae (HP:0001065)1.88349645
137Oculomotor apraxia (HP:0000657)1.86161564
138Abnormal urine phosphate concentration (HP:0012599)1.85309832
139Sensorimotor neuropathy (HP:0007141)1.85049512
140Abnormality of saccadic eye movements (HP:0000570)1.82779709
141Abnormality of the fingertips (HP:0001211)1.82289655
142Absent speech (HP:0001344)1.81519497
143Hypercalciuria (HP:0002150)1.80425724
144Abnormality of ocular smooth pursuit (HP:0000617)1.80122451
145Infertility (HP:0000789)1.78579168
146Incomplete penetrance (HP:0003829)1.78189420
147Highly arched eyebrow (HP:0002553)1.77992594
148Limb ataxia (HP:0002070)1.77808888
149Dilated cardiomyopathy (HP:0001644)1.77285370
150Rapidly progressive (HP:0003678)1.77240454
151Ectopic kidney (HP:0000086)1.75324826
152Specific learning disability (HP:0001328)1.75218123
153Horizontal nystagmus (HP:0000666)1.74720777
154Lower limb asymmetry (HP:0100559)1.72846586
155Hyperthyroidism (HP:0000836)1.72834215
156Anal stenosis (HP:0002025)1.72020975
157Resting tremor (HP:0002322)1.71933318
158Generalized myoclonic seizures (HP:0002123)1.70987111
159Nasal polyposis (HP:0100582)1.69679193
160Male infertility (HP:0003251)1.69576783
161Narrow nasal bridge (HP:0000446)1.69483075
162Psychosis (HP:0000709)1.69290368
163Neoplasm of the peripheral nervous system (HP:0100007)1.68682091
164Abnormality of salivation (HP:0100755)1.68641905
165Pointed chin (HP:0000307)1.67601611
166Open mouth (HP:0000194)1.66678872
167Hyperkalemia (HP:0002153)1.65753502
168Gait imbalance (HP:0002141)1.64731600
169Morphological abnormality of the pyramidal tract (HP:0002062)1.64671374
170Akinesia (HP:0002304)1.64020780
171Gingival overgrowth (HP:0000212)1.62400471
172Delayed eruption of teeth (HP:0000684)1.62326910
173Abnormal ciliary motility (HP:0012262)1.60351687
174Aplasia/Hypoplasia of the earlobes (HP:0009906)1.59212035
175Severe visual impairment (HP:0001141)1.59083500
176Abnormality of macular pigmentation (HP:0008002)1.57602685
177Ureteral stenosis (HP:0000071)1.57106501
178Skin pits (HP:0100276)1.52289502
179Chondrocalcinosis (HP:0000934)1.52250688
180Prominent supraorbital ridges (HP:0000336)1.52174217
181Small hand (HP:0200055)1.50998629
182Abnormality of Sharpey fibers (HP:0100685)1.50097624
183Growth hormone deficiency (HP:0000824)1.48691679
184Bony spicule pigmentary retinopathy (HP:0007737)1.44765218
185Ureteral obstruction (HP:0006000)1.40738067
186Decreased muscle mass (HP:0003199)1.38605572
187Abnormality of the nasal mucosa (HP:0000433)1.36327158
188True hermaphroditism (HP:0010459)1.36143011
189Prominent nasal bridge (HP:0000426)1.35242997
190Tubulointerstitial abnormality (HP:0001969)1.35139166
191Sudden cardiac death (HP:0001645)1.34064739
192Pancreatic fibrosis (HP:0100732)1.33199984
193Occipital encephalocele (HP:0002085)1.32983233

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.49876196
2STK33.89751272
3MAP4K13.78162611
4MAP3K93.73472829
5EPHA43.60306584
6BLK3.31616756
7SIK33.12765625
8MINK13.00528875
9MAP3K42.77517820
10KSR12.65465539
11MARK12.61172021
12DAPK22.50531747
13KSR22.38636741
14MAP2K72.23639648
15NTRK12.21939397
16CASK2.20902711
17PLK42.15681663
18INSRR2.08604320
19PAK62.08557727
20GRK51.84411309
21BCR1.75399918
22MAP2K41.73638251
23MAPK151.73170704
24NTRK21.67661323
25ARAF1.62210994
26CAMKK11.53799820
27BMPR21.46982152
28PLK21.43591831
29MAP3K131.40058350
30DAPK11.39983432
31CDK51.37994254
32MAP4K21.37372408
33BRD41.34156627
34AKT31.32725283
35UHMK11.31734494
36PRKD31.30235463
37CAMKK21.29027860
38LATS21.28911102
39MAP3K21.25373958
40FRK1.25104321
41SIK21.23374406
42MAPK131.22376513
43PRKCG1.20326224
44CDK191.19230985
45PAK31.18429337
46SGK2231.17464400
47SGK4941.17464400
48MAP3K121.10824082
49CDK181.07856330
50RIPK41.06280629
51GRK71.05341455
52CAMK2A1.03888554
53TYRO31.02991149
54DYRK1A1.01879208
55FER1.01449234
56PIK3CG1.01031531
57PNCK0.96317751
58TAOK10.94697777
59SGK20.94121020
60STK380.93216961
61CDK150.89686037
62CDK140.89393246
63MAP2K10.88334177
64SRPK10.86758061
65OBSCN0.83592829
66RAF10.83312118
67FGFR10.82982639
68PRPF4B0.82695078
69CAMK1G0.81746072
70TNIK0.81703787
71PHKG10.81553768
72PHKG20.81553768
73BRAF0.76659181
74MST1R0.76330269
75CDK11A0.76299596
76HIPK20.73882103
77PTK2B0.73730804
78RET0.71727243
79STK110.71677612
80ROCK10.71407319
81CAMK2B0.71127647
82PRKAA10.70888301
83FES0.69877765
84OXSR10.69035570
85TNK20.67091953
86CAMK10.66420632
87SGK30.65091390
88MAP3K10.64768105
89MET0.64163875
90PRKCH0.62260226
91FGR0.61148837
92SGK10.60889472
93PRKCZ0.60275362
94SRC0.56378124
95ICK0.55802212
96STK38L0.55524821
97WNK40.55449360
98DDR20.55210352
99NEK10.53958358
100MUSK0.53190459
101WNK30.52742495
102LMTK20.52674893
103GRK10.52335197
104PRKACB0.51056784
105CAMK40.49798077
106LATS10.49604700
107PRKCE0.48082005
108PINK10.47084564
109MAP3K70.47043081
110NEK60.46312039
111GSK3B0.46140920
112CAMK2G0.45945884
113RPS6KA30.45916232
114PDPK10.44992231
115ALK0.44721078
116ADRBK20.42745777
117PDK10.42206936
118GRK60.41831854
119ADRBK10.41626145
120MAPK140.41490060
121MARK20.39180569
122ROCK20.38159456
123DAPK30.37215397
124MAPK100.36779927
125PRKCQ0.35764094
126CAMK2D0.35488564
127PRKACA0.35377849
128RPS6KA20.35246847
129ABL10.35013044
130CDC42BPA0.34887722
131PIK3CA0.34522536
132CDK10.34484612
133TRPM70.34036286
134PRKACG0.33969270
135ERBB40.33819451
136CSNK1G20.33664535
137PRKCB0.33642660
138STK390.32775907
139MYLK0.32429771
140CSNK1E0.31183660
141WNK10.29834194
142PLK10.29739580
143CDK30.29333170
144TTN0.26285635
145PKN10.26007689
146PRKG10.25121282
147BMPR1B0.24490677
148PRKCA0.23793231
149PRKDC0.20014386
150CDK120.18994360
151TLK10.18833811
152MKNK20.18704821
153CDK20.17808487
154MAP2K60.17304036
155MAPK90.15198747
156CSNK1A10.14823989
157SYK0.14233444
158MAP2K20.14091855
159MAPK10.13631120
160MOS0.13329864
161CDC70.09934677
162AKT10.09433478
163ERBB30.09153683

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.41829618
2Synaptic vesicle cycle_Homo sapiens_hsa047213.38125314
3Nicotine addiction_Homo sapiens_hsa050333.37272369
4Sulfur metabolism_Homo sapiens_hsa009203.12303406
5Ovarian steroidogenesis_Homo sapiens_hsa049132.97224965
6Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.88620504
7Linoleic acid metabolism_Homo sapiens_hsa005912.55693890
8GABAergic synapse_Homo sapiens_hsa047272.55138206
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.54500664
10Long-term potentiation_Homo sapiens_hsa047202.46933857
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.43743047
12Circadian entrainment_Homo sapiens_hsa047132.42046906
13Olfactory transduction_Homo sapiens_hsa047402.38886555
14Amphetamine addiction_Homo sapiens_hsa050312.35839129
15Morphine addiction_Homo sapiens_hsa050322.27976755
16Glutamatergic synapse_Homo sapiens_hsa047242.19630687
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18509947
18Salivary secretion_Homo sapiens_hsa049702.04897103
19Dopaminergic synapse_Homo sapiens_hsa047281.96689752
20Fat digestion and absorption_Homo sapiens_hsa049751.81084843
21Collecting duct acid secretion_Homo sapiens_hsa049661.77697643
22Insulin secretion_Homo sapiens_hsa049111.77266024
23Taste transduction_Homo sapiens_hsa047421.76299118
24Renin secretion_Homo sapiens_hsa049241.71867260
25Gastric acid secretion_Homo sapiens_hsa049711.70859462
26Cholinergic synapse_Homo sapiens_hsa047251.69080528
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66726885
28Serotonergic synapse_Homo sapiens_hsa047261.63998578
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57161127
30Circadian rhythm_Homo sapiens_hsa047101.55781220
31Long-term depression_Homo sapiens_hsa047301.54679090
32Cocaine addiction_Homo sapiens_hsa050301.52598369
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51187021
34Oxytocin signaling pathway_Homo sapiens_hsa049211.49683971
35Calcium signaling pathway_Homo sapiens_hsa040201.48915387
36Gap junction_Homo sapiens_hsa045401.39152465
37Cardiac muscle contraction_Homo sapiens_hsa042601.33158902
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32002309
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.31948870
40Ether lipid metabolism_Homo sapiens_hsa005651.28113773
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23361090
42GnRH signaling pathway_Homo sapiens_hsa049121.21214643
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19242479
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13432430
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09372936
46Vibrio cholerae infection_Homo sapiens_hsa051101.08436152
47Arachidonic acid metabolism_Homo sapiens_hsa005901.07925801
48cAMP signaling pathway_Homo sapiens_hsa040241.07528567
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07073754
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04391615
51Phototransduction_Homo sapiens_hsa047441.02814823
52Nitrogen metabolism_Homo sapiens_hsa009101.02813291
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01885458
54Oxidative phosphorylation_Homo sapiens_hsa001901.00834875
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00722893
56Type II diabetes mellitus_Homo sapiens_hsa049300.99222964
57Glioma_Homo sapiens_hsa052140.98314787
58Estrogen signaling pathway_Homo sapiens_hsa049150.95329252
59Butanoate metabolism_Homo sapiens_hsa006500.94361113
60Alzheimers disease_Homo sapiens_hsa050100.93341218
61Melanogenesis_Homo sapiens_hsa049160.93123811
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89579245
63ECM-receptor interaction_Homo sapiens_hsa045120.89504801
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89450297
65Platelet activation_Homo sapiens_hsa046110.88956319
66Bile secretion_Homo sapiens_hsa049760.88799773
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88565689
68ErbB signaling pathway_Homo sapiens_hsa040120.88549365
69Axon guidance_Homo sapiens_hsa043600.88084707
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.84190649
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78347983
72Glucagon signaling pathway_Homo sapiens_hsa049220.76177041
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74791514
74Parkinsons disease_Homo sapiens_hsa050120.73774824
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.73592369
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73251163
77Arginine biosynthesis_Homo sapiens_hsa002200.69998248
78Dilated cardiomyopathy_Homo sapiens_hsa054140.69254828
79Oocyte meiosis_Homo sapiens_hsa041140.68890621
80Hedgehog signaling pathway_Homo sapiens_hsa043400.66752918
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66674965
82Thyroid hormone synthesis_Homo sapiens_hsa049180.64771033
83Pyruvate metabolism_Homo sapiens_hsa006200.60719239
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59313280
85Prion diseases_Homo sapiens_hsa050200.58539318
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57361994
87Dorso-ventral axis formation_Homo sapiens_hsa043200.57258721
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.56526164
89ABC transporters_Homo sapiens_hsa020100.55881041
90Pancreatic secretion_Homo sapiens_hsa049720.54035126
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53520095
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.52003745
93RNA degradation_Homo sapiens_hsa030180.51960442
94Insulin signaling pathway_Homo sapiens_hsa049100.50153629
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49135912
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.48516512
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45971883
98Huntingtons disease_Homo sapiens_hsa050160.45830634
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.44785257
100MAPK signaling pathway_Homo sapiens_hsa040100.43523491
101Alcoholism_Homo sapiens_hsa050340.41588742
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40517464
103mTOR signaling pathway_Homo sapiens_hsa041500.40300874
104Choline metabolism in cancer_Homo sapiens_hsa052310.40229633
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.39094441
106Chemokine signaling pathway_Homo sapiens_hsa040620.38159152
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37901839
108Propanoate metabolism_Homo sapiens_hsa006400.37745892
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37441934
110Rap1 signaling pathway_Homo sapiens_hsa040150.36386899
111VEGF signaling pathway_Homo sapiens_hsa043700.34537781
112Ras signaling pathway_Homo sapiens_hsa040140.33863997
113Non-small cell lung cancer_Homo sapiens_hsa052230.31716763
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31656260
115Renal cell carcinoma_Homo sapiens_hsa052110.30797054
116Purine metabolism_Homo sapiens_hsa002300.29787222
117Inositol phosphate metabolism_Homo sapiens_hsa005620.28679395
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.27527355
119Vitamin B6 metabolism_Homo sapiens_hsa007500.27349575
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26838155
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26490630
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.25058245
123Fatty acid biosynthesis_Homo sapiens_hsa000610.24738524
124Rheumatoid arthritis_Homo sapiens_hsa053230.24588408
125Retinol metabolism_Homo sapiens_hsa008300.23784556
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23548889
127Chemical carcinogenesis_Homo sapiens_hsa052040.21815172
128Phenylalanine metabolism_Homo sapiens_hsa003600.18991756
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.17309496
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.14500555
131Tyrosine metabolism_Homo sapiens_hsa003500.11144304
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.08826811
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.07815947
134Hippo signaling pathway_Homo sapiens_hsa043900.04972210
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.02170389
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.01166976
137Insulin resistance_Homo sapiens_hsa049310.00797078
138Pathways in cancer_Homo sapiens_hsa052000.00025404

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