GPR137

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.09426096
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.94746951
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.77550129
4cell-cell junction maintenance (GO:0045217)4.66799875
5locomotory exploration behavior (GO:0035641)4.53350319
6synaptic vesicle exocytosis (GO:0016079)4.45928302
7regulation of synaptic vesicle exocytosis (GO:2000300)4.37064807
8vocalization behavior (GO:0071625)4.31801599
9glutamate secretion (GO:0014047)4.31407821
10protein retention in ER lumen (GO:0006621)4.23306856
11regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)4.13153664
12regulation of early endosome to late endosome transport (GO:2000641)4.04526032
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.01766965
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.97442432
15regulation of synaptic vesicle transport (GO:1902803)3.96328351
16neuronal action potential propagation (GO:0019227)3.83674330
17regulation of synapse structural plasticity (GO:0051823)3.75089812
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.73625016
19neurotransmitter secretion (GO:0007269)3.71187764
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.68812039
21peptidyl-tyrosine autophosphorylation (GO:0038083)3.67853618
22regulation of neuronal synaptic plasticity (GO:0048168)3.63624242
23negative regulation of cell size (GO:0045792)3.62664035
24sodium ion export (GO:0071436)3.60025953
25response to acidic pH (GO:0010447)3.58202408
26cellular potassium ion homeostasis (GO:0030007)3.54937448
27cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.53451939
28neuromuscular process controlling posture (GO:0050884)3.53300147
29layer formation in cerebral cortex (GO:0021819)3.52400978
30regulation of glutamate receptor signaling pathway (GO:1900449)3.50957594
31activation of protein kinase A activity (GO:0034199)3.48504685
32semaphorin-plexin signaling pathway (GO:0071526)3.47028879
33sperm capacitation (GO:0048240)3.45469123
34gamma-aminobutyric acid transport (GO:0015812)3.43918736
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.39878056
36exploration behavior (GO:0035640)3.37506208
37proline transport (GO:0015824)3.34905064
38cell junction maintenance (GO:0034331)3.34412396
39protein localization to endosome (GO:0036010)3.33565172
40positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.29658614
41cell communication by electrical coupling (GO:0010644)3.29560152
42protein localization to synapse (GO:0035418)3.26926584
43endothelial cell chemotaxis (GO:0035767)3.24873256
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.23745183
45cerebellar granule cell differentiation (GO:0021707)3.23372753
46retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.20203867
47glycine transport (GO:0015816)3.15300215
48ionotropic glutamate receptor signaling pathway (GO:0035235)3.09156255
49long-term memory (GO:0007616)3.09059428
50positive regulation of neurotransmitter secretion (GO:0001956)3.07717139
51regulation of mammary gland epithelial cell proliferation (GO:0033599)3.05081092
52protein maturation by protein folding (GO:0022417)3.05050912
53calcium ion-dependent exocytosis (GO:0017156)3.04645532
54membrane depolarization during action potential (GO:0086010)3.02574547
55regulation of ARF protein signal transduction (GO:0032012)3.02316439
56negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.99979940
57receptor recycling (GO:0001881)2.98456214
58neurotransmitter transport (GO:0006836)2.97147601
59neuron cell-cell adhesion (GO:0007158)2.96413996
60positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96039395
61negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.95962729
62dendritic spine morphogenesis (GO:0060997)2.95445940
63protein insertion into membrane (GO:0051205)2.95295563
64adenosine receptor signaling pathway (GO:0001973)2.93560434
65regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.90484333
66cellular response to pH (GO:0071467)2.90192424
67cerebellar Purkinje cell differentiation (GO:0021702)2.90192051
68potassium ion import (GO:0010107)2.90125549
69neuromuscular process controlling balance (GO:0050885)2.89377735
70intracellular estrogen receptor signaling pathway (GO:0030520)2.87107073
71neurotransmitter-gated ion channel clustering (GO:0072578)2.85674551
72synaptic transmission, glutamatergic (GO:0035249)2.85533977
73proline biosynthetic process (GO:0006561)2.83516897
74cerebellar Purkinje cell layer development (GO:0021680)2.82126450
75G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.81079137
76positive regulation of synapse maturation (GO:0090129)2.80066350
77modulation by virus of host process (GO:0019054)2.78474683
78positive regulation of synaptic transmission, GABAergic (GO:0032230)2.78266340
79regulation of neurotransmitter levels (GO:0001505)2.78032738
80fusion of sperm to egg plasma membrane (GO:0007342)2.77728124
81positive regulation of membrane potential (GO:0045838)2.77263860
82COPI coating of Golgi vesicle (GO:0048205)2.76800224
83Golgi transport vesicle coating (GO:0048200)2.76800224
84regulation of synaptic plasticity (GO:0048167)2.76356896
85neuronal ion channel clustering (GO:0045161)2.75777440
86myelin maintenance (GO:0043217)2.72494576
87stress fiber assembly (GO:0043149)2.72435978
88cellular component maintenance (GO:0043954)2.72313979
89positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.71655154
90protein targeting to plasma membrane (GO:0072661)2.68971838
91dendritic spine organization (GO:0097061)2.68660898
92regulation of neurotransmitter secretion (GO:0046928)2.68077557
93synaptic vesicle endocytosis (GO:0048488)2.67041652
94regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.66217499
95positive regulation of potassium ion transmembrane transport (GO:1901381)2.65310964
96positive regulation of histone deacetylation (GO:0031065)2.65243762
97regulation of excitatory postsynaptic membrane potential (GO:0060079)2.64790838
98alanine transport (GO:0032328)2.64460718
99modulation by symbiont of host cellular process (GO:0044068)2.64239773
100modulation by virus of host morphology or physiology (GO:0019048)2.64165507
101positive regulation of protein dephosphorylation (GO:0035307)2.64050055
102sperm motility (GO:0030317)2.63683018
103potassium ion homeostasis (GO:0055075)2.63032474
104neuron-neuron synaptic transmission (GO:0007270)2.62637751
105dopamine receptor signaling pathway (GO:0007212)2.62235250
106positive regulation of neurotransmitter transport (GO:0051590)2.61715720
107planar cell polarity pathway involved in neural tube closure (GO:0090179)2.61430669
108basement membrane organization (GO:0071711)2.59706544
109glutamate receptor signaling pathway (GO:0007215)2.59652141
110regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.58628325
111cell migration in hindbrain (GO:0021535)2.57788099
112regulation of chromatin binding (GO:0035561)2.57742867
113cell communication involved in cardiac conduction (GO:0086065)2.57091481
114dendrite morphogenesis (GO:0048813)2.57062370
115GDP-mannose metabolic process (GO:0019673)2.54981754
116tooth mineralization (GO:0034505)2.54843653
117adherens junction assembly (GO:0034333)2.54792630
118mitochondrion degradation (GO:0000422)2.54533657
119activation of MAPKKK activity (GO:0000185)2.53984794
120positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.53664646
121acrosome reaction (GO:0007340)2.53593971
122regulation of postsynaptic membrane potential (GO:0060078)2.53484254
123transmission of nerve impulse (GO:0019226)2.52988240
124neuron recognition (GO:0008038)2.52893546
125response to auditory stimulus (GO:0010996)2.52842208
126regulation of T-helper 2 cell differentiation (GO:0045628)2.52501338
127mating behavior (GO:0007617)2.51925001
128regulation of neurotransmitter transport (GO:0051588)2.50573365
129long-term synaptic potentiation (GO:0060291)2.50440345
130membrane depolarization (GO:0051899)2.50060069
131barbed-end actin filament capping (GO:0051016)2.49739253
132positive regulation of Cdc42 GTPase activity (GO:0043089)2.49112277
133establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.47563835
134mitochondrion transport along microtubule (GO:0047497)2.47563835
135regulation of voltage-gated calcium channel activity (GO:1901385)2.47487812
136establishment of mitochondrion localization (GO:0051654)2.47427382
137neuromuscular process (GO:0050905)2.47019625
138cellular sodium ion homeostasis (GO:0006883)2.46748981
139peptidyl-proline hydroxylation (GO:0019511)2.46580342
140regulation of inclusion body assembly (GO:0090083)2.45720985
141regulation of ARF GTPase activity (GO:0032312)2.45445201
142positive regulation of potassium ion transport (GO:0043268)2.45334219
143axon cargo transport (GO:0008088)2.45117218
144activation of Rac GTPase activity (GO:0032863)2.44942897
145regulation of vesicle fusion (GO:0031338)2.43925027
146endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.43797415
147regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.43629650
148microtubule severing (GO:0051013)2.43471357
149membrane repolarization (GO:0086009)2.43222191
150regulation of protein targeting to membrane (GO:0090313)2.42347469
151vesicle transport along microtubule (GO:0047496)2.41786309
152L-amino acid import (GO:0043092)2.41295317
153cytoskeletal anchoring at plasma membrane (GO:0007016)2.41114188
154regulation of calcium ion-dependent exocytosis (GO:0017158)2.40098189
155membrane hyperpolarization (GO:0060081)2.39213983
156actin filament bundle organization (GO:0061572)2.38646967
157actin filament bundle assembly (GO:0051017)2.38646967
158negative regulation of inclusion body assembly (GO:0090084)2.38349518
159positive regulation of synaptic transmission (GO:0050806)2.37772863
160adult walking behavior (GO:0007628)2.37547881
161regulation of synaptic transmission (GO:0050804)2.37511900
162regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.37338610
163endocytic recycling (GO:0032456)2.37181383
164mannose metabolic process (GO:0006013)2.36710524
165regulation of calcium ion transmembrane transporter activity (GO:1901019)2.35606071
166regulation of calcium ion transmembrane transport (GO:1903169)2.35606071
167skeletal muscle organ development (GO:0060538)2.35575102
168negative regulation of microtubule polymerization (GO:0031115)2.34883757
169regulation of cholesterol biosynthetic process (GO:0045540)2.34477136
170prepulse inhibition (GO:0060134)2.34353836
171membrane protein intracellular domain proteolysis (GO:0031293)2.33346073
172polyamine biosynthetic process (GO:0006596)2.33204969

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.04778910
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.52407119
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.49008963
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.44202445
5SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43860939
6DROSHA_22980978_ChIP-Seq_HELA_Human2.40880793
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.38400671
8REST_21632747_ChIP-Seq_MESCs_Mouse2.37727679
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.37193986
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36582618
11VDR_21846776_ChIP-Seq_THP-1_Human2.26900315
12* RACK7_27058665_Chip-Seq_MCF-7_Human2.25535475
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25319679
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25319679
15* ELK3_25401928_ChIP-Seq_HUVEC_Human2.23440880
16P68_20966046_ChIP-Seq_HELA_Human2.23305951
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.20768692
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18357001
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18235612
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.18048335
21* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12678526
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.07656418
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.05448589
24STAT6_21828071_ChIP-Seq_BEAS2B_Human2.04743863
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04121336
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.03825895
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03576826
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.97065633
29SRY_22984422_ChIP-ChIP_TESTIS_Rat1.90694503
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83951540
31GBX2_23144817_ChIP-Seq_PC3_Human1.82589343
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.81535050
33ELF1_20517297_ChIP-Seq_JURKAT_Human1.80359522
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.79872313
35* SA1_27219007_Chip-Seq_ERYTHROID_Human1.76513888
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76016835
37* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.70215772
38* TCF7_22412390_ChIP-Seq_EML_Mouse1.68194581
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.66127713
40BCOR_27268052_Chip-Seq_Bcells_Human1.63194254
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.63176937
42BCL6_27268052_Chip-Seq_Bcells_Human1.62557688
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.61623047
44UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.61040779
45MYC_22102868_ChIP-Seq_BL_Human1.60746833
46* CREB1_26743006_Chip-Seq_LNCaP_Human1.58965801
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.57112250
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51904947
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50063093
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.47484184
51CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.43313820
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42757315
53* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42327752
54ZNF263_19887448_ChIP-Seq_K562_Human1.39657976
55KDM2B_26808549_Chip-Seq_K562_Human1.37943724
56* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37047991
57RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.33493723
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33055796
59TP63_17297297_ChIP-ChIP_HaCaT_Human1.32957460
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32860775
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.31510344
62TP53_22127205_ChIP-Seq_IMR90_Human1.31361261
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30121669
64PHF8_20622854_ChIP-Seq_HELA_Human1.29611030
65* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29152636
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28959157
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27379494
68CTCF_20526341_ChIP-Seq_ESCs_Human1.26750040
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24586219
70SA1_27219007_Chip-Seq_Bcells_Human1.24196795
71E2F1_20622854_ChIP-Seq_HELA_Human1.23027809
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.22845445
73LXR_22292898_ChIP-Seq_THP-1_Human1.20935852
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19174579
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19132650
76* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18963359
77RARA_24833708_ChIP-Seq_LIVER_Mouse1.18542409
78RARB_24833708_ChIP-Seq_LIVER_Mouse1.17336427
79* CTCF_27219007_Chip-Seq_Bcells_Human1.17067414
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15961873
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15681441
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15438945
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15310578
84YY1_22570637_ChIP-Seq_MALME-3M_Human1.15180614
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14935146
86ZNF274_21170338_ChIP-Seq_K562_Hela1.14594672
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14198336
88* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.13693394
89NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13094558
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12495630
91CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12408859
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11865414
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10791285
94VDR_24763502_ChIP-Seq_THP-1_Human1.10191153
95* MAF_26560356_Chip-Seq_TH2_Human1.09764294
96TET1_21490601_ChIP-Seq_MESCs_Mouse1.09567547
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08363847
98JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.06874736
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06456611
100* CTCF_21964334_Chip-Seq_Bcells_Human1.06171285
101RUNX1_27514584_Chip-Seq_MCF-7_Human1.05516989
102E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05288034
103* FOXP1_21924763_ChIP-Seq_HESCs_Human1.05077701
104ATF3_27146783_Chip-Seq_COLON_Human1.04652166
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04061807
106CTCF_26484167_Chip-Seq_Bcells_Mouse1.03974034
107ETS1_21867929_ChIP-Seq_TH2_Mouse1.03858018
108SMC4_20622854_ChIP-Seq_HELA_Human1.03740146
109* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03553040
110CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02732342
111* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01822799
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01613199
113CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01204611
114ESR2_21235772_ChIP-Seq_MCF-7_Human1.00193419
115DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99903743
116AR_21572438_ChIP-Seq_LNCaP_Human0.99731706
117CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99033296
118GATA1_19941827_ChIP-Seq_MEL_Mouse0.98690339
119NCOR1_26117541_ChIP-Seq_K562_Human0.98359659
120CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98168415
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97249323
122EP300_21415370_ChIP-Seq_HL-1_Mouse0.95813442
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95288955
124SOX2_21211035_ChIP-Seq_LN229_Gbm0.94875826
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94816979
126KLF4_19829295_ChIP-Seq_ESCs_Human0.93444566
127SMAD4_21799915_ChIP-Seq_A2780_Human0.93131075
128AR_19668381_ChIP-Seq_PC3_Human0.90236638
129PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87811980
130PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86753081
131OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86602635
132CTBP1_25329375_ChIP-Seq_LNCAP_Human0.85906166
133SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84980799
134OCT4_19829295_ChIP-Seq_ESCs_Human0.84917474
135TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84308783
136SMAD3_21741376_ChIP-Seq_ESCs_Human0.83140907
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.82607123
138SMAD4_21741376_ChIP-Seq_HESCs_Human0.81112028
139RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.81098347
140TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80978313
141ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.79789160
142ELK4_26923725_Chip-Seq_MESODERM_Mouse0.79587373
143* RING1B_27294783_Chip-Seq_NPCs_Mouse0.78558110
144RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.78303333
145ZNF217_24962896_ChIP-Seq_MCF-7_Human0.77166257
146* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.75888704
147VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75749116
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.75597304
149P53_22127205_ChIP-Seq_FIBROBLAST_Human0.74665536
150SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.74581915
151AHR_22903824_ChIP-Seq_MCF-7_Human0.74524382
152SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.74370077
153* TP63_22573176_ChIP-Seq_HFKS_Human0.73674164
154ARNT_22903824_ChIP-Seq_MCF-7_Human0.73486915
155AR_25329375_ChIP-Seq_VCAP_Human0.71325895
156KDM2B_26808549_Chip-Seq_DND41_Human0.70746741
157TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70450607
158SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.70416157
159SMAD3_21741376_ChIP-Seq_HESCs_Human0.70396191
160STAT3_23295773_ChIP-Seq_U87_Human0.70393783
161ZFP281_27345836_Chip-Seq_ESCs_Mouse0.69214113
162TET1_21451524_ChIP-Seq_MESCs_Mouse0.68447372
163SMAD4_21741376_ChIP-Seq_ESCs_Human0.67574026

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.77494299
2MP0003635_abnormal_synaptic_transmissio3.54758728
3MP0003880_abnormal_central_pattern3.40258013
4MP0004270_analgesia3.35736945
5MP0003705_abnormal_hypodermis_morpholog3.32892857
6MP0005451_abnormal_body_composition3.21075952
7MP0009745_abnormal_behavioral_response2.78662245
8MP0002064_seizures2.77894059
9MP0009046_muscle_twitch2.76674978
10MP0001348_abnormal_lacrimal_gland2.76347800
11MP0002063_abnormal_learning/memory/cond2.75647991
12MP0003329_amyloid_beta_deposits2.61184183
13MP0004858_abnormal_nervous_system2.54317708
14MP0001968_abnormal_touch/_nociception2.49970219
15MP0000678_abnormal_parathyroid_gland2.35323738
16MP0002272_abnormal_nervous_system2.31016647
17MP0005670_abnormal_white_adipose2.27936824
18MP0002572_abnormal_emotion/affect_behav2.24732951
19MP0005377_hearing/vestibular/ear_phenot2.22891160
20MP0003878_abnormal_ear_physiology2.22891160
21MP0002837_dystrophic_cardiac_calcinosis2.21568571
22MP0005410_abnormal_fertilization2.20378280
23MP0002734_abnormal_mechanical_nocicepti2.17211513
24MP0002822_catalepsy2.15189345
25MP0002249_abnormal_larynx_morphology2.07074057
26MP0002735_abnormal_chemical_nociception2.06351912
27MP0002909_abnormal_adrenal_gland2.03004861
28MP0005423_abnormal_somatic_nervous1.97499811
29MP0001486_abnormal_startle_reflex1.96415701
30MP0008569_lethality_at_weaning1.95093795
31MP0001501_abnormal_sleep_pattern1.94914606
32MP0002736_abnormal_nociception_after1.94732054
33MP0008260_abnormal_autophagy1.90509800
34MP0002733_abnormal_thermal_nociception1.84646792
35MP0001440_abnormal_grooming_behavior1.82362360
36MP0000751_myopathy1.79463239
37MP0002653_abnormal_ependyma_morphology1.78520823
38MP0001970_abnormal_pain_threshold1.77456808
39MP0000537_abnormal_urethra_morphology1.76585636
40MP0009780_abnormal_chondrocyte_physiolo1.75786393
41MP0004885_abnormal_endolymph1.74842396
42MP0004185_abnormal_adipocyte_glucose1.68279852
43MP0005666_abnormal_adipose_tissue1.67660691
44MP0003646_muscle_fatigue1.66216832
45MP0004811_abnormal_neuron_physiology1.63992816
46MP0002067_abnormal_sensory_capabilities1.57131751
47MP0003633_abnormal_nervous_system1.55231555
48MP0003879_abnormal_hair_cell1.53270408
49MP0001849_ear_inflammation1.52638935
50MP0005310_abnormal_salivary_gland1.51454777
51MP0000604_amyloidosis1.50372603
52MP0005409_darkened_coat_color1.47026307
53MP0000955_abnormal_spinal_cord1.46289194
54MP0002089_abnormal_postnatal_growth/wei1.45363818
55MP0003123_paternal_imprinting1.40894704
56MP0002184_abnormal_innervation1.40059099
57MP0005257_abnormal_intraocular_pressure1.37614857
58MP0002557_abnormal_social/conspecific_i1.36739384
59MP0000920_abnormal_myelination1.36521112
60MP0000013_abnormal_adipose_tissue1.33447490
61MP0000778_abnormal_nervous_system1.32300549
62MP0002066_abnormal_motor_capabilities/c1.31066623
63MP0004924_abnormal_behavior1.30363692
64MP0005386_behavior/neurological_phenoty1.30363692
65MP0003690_abnormal_glial_cell1.29456562
66MP0005076_abnormal_cell_differentiation1.27781323
67MP0006276_abnormal_autonomic_nervous1.27342470
68MP0005375_adipose_tissue_phenotype1.25678836
69MP0000681_abnormal_thyroid_gland1.24615293
70MP0001984_abnormal_olfaction1.24231136
71MP0005535_abnormal_body_temperature1.24105306
72MP0009278_abnormal_bone_marrow1.23743057
73MP0003631_nervous_system_phenotype1.22769902
74MP0004043_abnormal_pH_regulation1.21438290
75MP0002882_abnormal_neuron_morphology1.20352853
76MP0003075_altered_response_to1.20324300
77MP0005167_abnormal_blood-brain_barrier1.19798297
78MP0008961_abnormal_basal_metabolism1.19042183
79MP0000534_abnormal_ureter_morphology1.17577040
80MP0010386_abnormal_urinary_bladder1.17148169
81MP0005646_abnormal_pituitary_gland1.14780142
82MP0003195_calcinosis1.14523937
83MP0003634_abnormal_glial_cell1.13939713
84MP0004145_abnormal_muscle_electrophysio1.13188220
85MP0004142_abnormal_muscle_tone1.12775830
86MP0001502_abnormal_circadian_rhythm1.10230995
87MP0004036_abnormal_muscle_relaxation1.08779029
88MP0004130_abnormal_muscle_cell1.07567981
89MP0003091_abnormal_cell_migration1.06422710
90MP0002229_neurodegeneration1.06200472
91MP0003453_abnormal_keratinocyte_physiol1.05777946
92MP0010234_abnormal_vibrissa_follicle1.05594780
93MP0008874_decreased_physiological_sensi1.03936933
94MP0009053_abnormal_anal_canal1.02899418
95MP0004510_myositis1.02583069
96MP0005623_abnormal_meninges_morphology0.96678504
97MP0000747_muscle_weakness0.95259245
98MP0004085_abnormal_heartbeat0.94457760
99MP0003566_abnormal_cell_adhesion0.92645541
100MP0010030_abnormal_orbit_morphology0.91896095
101MP0003942_abnormal_urinary_system0.91781874
102MP0003172_abnormal_lysosome_physiology0.91151880
103MP0005083_abnormal_biliary_tract0.88970446
104MP0001905_abnormal_dopamine_level0.88801601
105MP0002069_abnormal_eating/drinking_beha0.88206003
106MP0004215_abnormal_myocardial_fiber0.86832203
107MP0003283_abnormal_digestive_organ0.86319752
108MP0002152_abnormal_brain_morphology0.85578983
109MP0001873_stomach_inflammation0.85530370
110MP0000003_abnormal_adipose_tissue0.85087896
111MP0000749_muscle_degeneration0.83898160
112MP0008872_abnormal_physiological_respon0.82984879
113MP0003632_abnormal_nervous_system0.82569577
114MP0000750_abnormal_muscle_regeneration0.82108120
115MP0002090_abnormal_vision0.78796093
116MP0003303_peritoneal_inflammation0.78151352
117MP0004742_abnormal_vestibular_system0.78010796
118MP0001765_abnormal_ion_homeostasis0.77515037
119MP0003137_abnormal_impulse_conducting0.76594286
120MP0003122_maternal_imprinting0.76147680
121MP0000733_abnormal_muscle_development0.75789336
122MP0005464_abnormal_platelet_physiology0.75553450
123MP0003279_aneurysm0.75515223
124MP0005645_abnormal_hypothalamus_physiol0.75121377
125MP0002161_abnormal_fertility/fecundity0.74480090
126MP0005501_abnormal_skin_physiology0.73547870
127MP0009840_abnormal_foam_cell0.72878610
128MP0005584_abnormal_enzyme/coenzyme_acti0.72047614
129MP0005058_abnormal_lysosome_morphology0.71302303
130MP0004233_abnormal_muscle_weight0.70909573
131MP0002234_abnormal_pharynx_morphology0.69656428
132MP0003183_abnormal_peptide_metabolism0.69529676
133MP0002638_abnormal_pupillary_reflex0.69440186
134MP0008438_abnormal_cutaneous_collagen0.67940633
135MP0002269_muscular_atrophy0.67353011
136MP0003698_abnormal_male_reproductive0.67043194
137MP0002118_abnormal_lipid_homeostasis0.66933684
138MP0004484_altered_response_of0.66910979
139MP0001177_atelectasis0.66245864
140MP0001958_emphysema0.66124934
141MP0002877_abnormal_melanocyte_morpholog0.65803258
142MP0002078_abnormal_glucose_homeostasis0.64958588
143MP0005448_abnormal_energy_balance0.64723562
144MP0002796_impaired_skin_barrier0.64485714
145MP0004947_skin_inflammation0.62245211
146MP0001963_abnormal_hearing_physiology0.57092427

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.24179671
2Focal motor seizures (HP:0011153)4.73452559
3Visual hallucinations (HP:0002367)4.27695306
4Supranuclear gaze palsy (HP:0000605)4.02937521
5Action tremor (HP:0002345)4.00370995
6Focal seizures (HP:0007359)3.96155759
7Obstructive sleep apnea (HP:0002870)3.69490500
8Neurofibrillary tangles (HP:0002185)3.23732182
9Pheochromocytoma (HP:0002666)3.17317086
10Ankle clonus (HP:0011448)3.15115161
11Depression (HP:0000716)3.14961919
12Progressive cerebellar ataxia (HP:0002073)3.14871985
13Hyperacusis (HP:0010780)3.12638159
14Testicular atrophy (HP:0000029)3.06711049
15Atonic seizures (HP:0010819)3.00479776
16Hand muscle atrophy (HP:0009130)2.97411745
17Postural instability (HP:0002172)2.95864992
18Ventricular fibrillation (HP:0001663)2.95815965
19Torticollis (HP:0000473)2.94675174
20Focal dystonia (HP:0004373)2.93486444
21Abnormality of the lower motor neuron (HP:0002366)2.92389516
22Thin bony cortex (HP:0002753)2.84069704
23Cerebral inclusion bodies (HP:0100314)2.83307922
24Bundle branch block (HP:0011710)2.80501210
25Craniofacial dystonia (HP:0012179)2.79898809
26Absence seizures (HP:0002121)2.76709787
27Turricephaly (HP:0000262)2.75199034
28Epileptic encephalopathy (HP:0200134)2.74552288
29Anxiety (HP:0000739)2.73617784
30Cervical subluxation (HP:0003308)2.72919764
31Abnormal eating behavior (HP:0100738)2.67498397
32Generalized tonic-clonic seizures (HP:0002069)2.66637935
33Broad face (HP:0000283)2.64759214
34Flattened epiphyses (HP:0003071)2.62119535
35Neuroendocrine neoplasm (HP:0100634)2.61360936
36Dysmetria (HP:0001310)2.60266919
37Dynein arm defect of respiratory motile cilia (HP:0012255)2.59186742
38Absent/shortened dynein arms (HP:0200106)2.59186742
39Abnormal gallbladder physiology (HP:0012438)2.55469265
40Cholecystitis (HP:0001082)2.55469265
41Dysdiadochokinesis (HP:0002075)2.53146970
42Ulnar bowing (HP:0003031)2.52767116
43Vertebral compression fractures (HP:0002953)2.51857337
44Atelectasis (HP:0100750)2.51382786
45Axonal loss (HP:0003447)2.49117962
46Hyperthyroidism (HP:0000836)2.46025267
47Intention tremor (HP:0002080)2.43679721
48Urinary bladder sphincter dysfunction (HP:0002839)2.43649223
49Impaired vibration sensation in the lower limbs (HP:0002166)2.42670775
50Dialeptic seizures (HP:0011146)2.42021825
51Nasal polyposis (HP:0100582)2.41036545
52Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.40295129
53Stridor (HP:0010307)2.39365546
54Congenital glaucoma (HP:0001087)2.38615770
55Dysostosis multiplex (HP:0000943)2.38480636
56Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.36856671
57Hemorrhage of the eye (HP:0011885)2.36700127
58Spastic gait (HP:0002064)2.36519683
59Truncal ataxia (HP:0002078)2.35477231
60Abnormality of the nasal mucosa (HP:0000433)2.34256043
61Bradykinesia (HP:0002067)2.33500968
62Rapidly progressive (HP:0003678)2.33377640
63Febrile seizures (HP:0002373)2.32542597
64Urinary urgency (HP:0000012)2.32532946
65Annular pancreas (HP:0001734)2.32047164
66Hyperparathyroidism (HP:0000843)2.30462907
67Abnormality of the phalanges of the hallux (HP:0010057)2.29074448
68Protrusio acetabuli (HP:0003179)2.27501680
69Long palpebral fissure (HP:0000637)2.26931050
70Mutism (HP:0002300)2.26637320
71Nuclear cataract (HP:0100018)2.25790664
72Gaze-evoked nystagmus (HP:0000640)2.25407101
73Male infertility (HP:0003251)2.25282351
74Broad distal phalanx of finger (HP:0009836)2.25075407
75Abnormal social behavior (HP:0012433)2.24453398
76Impaired social interactions (HP:0000735)2.24453398
77Sudden death (HP:0001699)2.24380697
78Termporal pattern (HP:0011008)2.23726741
79Insidious onset (HP:0003587)2.23726741
80Hemiplegia (HP:0002301)2.20851581
81Shallow orbits (HP:0000586)2.20737979
82Growth hormone excess (HP:0000845)2.19637279
83Asymmetric septal hypertrophy (HP:0001670)2.19545827
84Megalencephaly (HP:0001355)2.17572219
85Dysmetric saccades (HP:0000641)2.15776158
86Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.14125545
87Poor eye contact (HP:0000817)2.12676480
88Resting tremor (HP:0002322)2.12265403
89Abnormal respiratory motile cilium physiology (HP:0012261)2.11279254
90Retinal dysplasia (HP:0007973)2.10848242
91Type II lissencephaly (HP:0007260)2.10821882
92Flat acetabular roof (HP:0003180)2.10484641
93Short nail (HP:0001799)2.09897418
94Cerebral aneurysm (HP:0004944)2.09022713
95Short femoral neck (HP:0100864)2.08033216
96Lower limb muscle weakness (HP:0007340)2.06639240
97Achilles tendon contracture (HP:0001771)2.04435778
98Abnormality of the distal phalanges of the toes (HP:0010182)2.03940898
99Exercise-induced myalgia (HP:0003738)2.03621540
100Prolonged neonatal jaundice (HP:0006579)2.03281698
101Rigidity (HP:0002063)2.02919712
102Truncus arteriosus (HP:0001660)2.02586857
103Abnormality of the distal phalanx of the thumb (HP:0009617)2.02137864
104Clonus (HP:0002169)2.01953427
105Amblyopia (HP:0000646)2.01075975
106Insomnia (HP:0100785)2.00819967
107Neuronal loss in central nervous system (HP:0002529)2.00608453
108Prolonged QT interval (HP:0001657)2.00521346
109Purpura (HP:0000979)2.00162218
110Abnormality of the Achilles tendon (HP:0005109)1.98944302
111Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97093724
112Abnormality of polysaccharide metabolism (HP:0011012)1.97093724
113Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97093724
114Apathy (HP:0000741)1.94482682
115Bulbar palsy (HP:0001283)1.94378965
116Impaired smooth pursuit (HP:0007772)1.94376792
117Abnormality of the aortic arch (HP:0012303)1.94127574
118Status epilepticus (HP:0002133)1.93825379
119Mucopolysacchariduria (HP:0008155)1.92870558
120Urinary glycosaminoglycan excretion (HP:0003541)1.92870558
121Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.92848124
122Polyphagia (HP:0002591)1.92820912
123Neoplasm of the peripheral nervous system (HP:0100007)1.92815234
124Distal lower limb muscle weakness (HP:0009053)1.91914623
125Global brain atrophy (HP:0002283)1.90558090
126Premature rupture of membranes (HP:0001788)1.90455019
127Agitation (HP:0000713)1.90250486
128Diminished motivation (HP:0000745)1.87978381
129Abnormal EKG (HP:0003115)1.87218341
130Increased cerebral lipofuscin (HP:0011813)1.86275719
131Peripheral hypomyelination (HP:0007182)1.86258064
132Genetic anticipation (HP:0003743)1.85434157
133Abnormality of saccadic eye movements (HP:0000570)1.85113002
134Hypercortisolism (HP:0001578)1.85027500
135Hemiparesis (HP:0001269)1.84260899
136Papilledema (HP:0001085)1.84166559
137J-shaped sella turcica (HP:0002680)1.84022345
138Postural tremor (HP:0002174)1.83032286
139Spinal cord compression (HP:0002176)1.82343797
140Hyperventilation (HP:0002883)1.80898085
141Aplasia/hypoplasia of the femur (HP:0005613)1.79562668
142Blue sclerae (HP:0000592)1.79506783
143Bell-shaped thorax (HP:0001591)1.79295420
144Patellar dislocation (HP:0002999)1.79051740
145Bowed forearm bones (HP:0003956)1.78264801
146Bowing of the arm (HP:0006488)1.78264801
147Genu recurvatum (HP:0002816)1.78176003
148Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.77949095
149Stereotypic behavior (HP:0000733)1.77865059
150Broad metatarsal (HP:0001783)1.77440777
151Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.76308924
152Easy fatigability (HP:0003388)1.75652677
153Spinal canal stenosis (HP:0003416)1.75509172
154EEG with generalized epileptiform discharges (HP:0011198)1.74754018
155Delusions (HP:0000746)1.74452145
156Infertility (HP:0000789)1.74330512
157Loss of speech (HP:0002371)1.74263852
158Akinesia (HP:0002304)1.74204571
159Dementia (HP:0000726)1.74027569
160Syncope (HP:0001279)1.73883446
161Progressive inability to walk (HP:0002505)1.73811794
162Spastic tetraparesis (HP:0001285)1.73744567
163Psychosis (HP:0000709)1.73681637
164Limb dystonia (HP:0002451)1.72938024
165Upper limb amyotrophy (HP:0009129)1.72877245
166Distal upper limb amyotrophy (HP:0007149)1.72877245
167Hypsarrhythmia (HP:0002521)1.72840186
168Abnormality of ocular smooth pursuit (HP:0000617)1.72828368
169Partial duplication of thumb phalanx (HP:0009944)1.72689861
170Onion bulb formation (HP:0003383)1.72656919
171Epileptiform EEG discharges (HP:0011182)1.72515884
172Severe visual impairment (HP:0001141)1.71593295
173Precocious puberty (HP:0000826)1.71540270
174Biconcave vertebral bodies (HP:0004586)1.71292747
175Abnormality of liposaccharide metabolism (HP:0010968)1.70126675
176Abnormality of glycosphingolipid metabolism (HP:0004343)1.70126675
177Abnormality of glycolipid metabolism (HP:0010969)1.70126675
178Fragile skin (HP:0001030)1.69475850
179Back pain (HP:0003418)1.68194408

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.54139580
2PRKD33.23784234
3NTRK33.04688281
4SMG12.88126606
5IRAK32.77495514
6EPHA42.69187591
7KSR22.58724831
8PAK62.58655405
9SIK12.49323074
10CAMK1D2.43579897
11DAPK22.32217051
12MINK12.28901005
13NTRK12.26872339
14MARK12.23940979
15MAP3K112.15078528
16MAP3K42.09314830
17TESK22.01182684
18CAMKK11.88275842
19PIM21.87549683
20PRKD21.84643480
21PDK31.73438092
22PDK41.73438092
23STK381.72617708
24LMTK21.69819759
25TRIB31.60634320
26ARAF1.60319364
27TESK11.57867022
28MAP2K71.57414043
29NME21.54165163
30MAP2K41.52352915
31DDR21.49489375
32PINK11.45674311
33PTK2B1.44678203
34PHKG21.42757138
35PHKG11.42757138
36WNK41.41035213
37MAP3K21.40347584
38NTRK21.39270983
39TAOK21.37787600
40CDK51.36876809
41EPHA21.33227610
42EEF2K1.32925853
43MAP3K121.28963816
44PKN21.28835563
45RIPK41.28736388
46STK391.25557070
47TAOK11.24017553
48UHMK11.22893055
49IRAK21.20932856
50SGK4941.19569213
51SGK2231.19569213
52CDK191.11201832
53GRK51.10910994
54ICK1.09964405
55CDK121.09002439
56RET1.07580498
57PRKCH1.06938493
58TYRO31.06579953
59KSR11.05961320
60OXSR11.05109761
61AKT31.03974559
62PDPK11.00312450
63MAP3K10.98931940
64PAK30.97556128
65PRKCG0.97352918
66PRKCI0.95555323
67MAP3K130.93983626
68PDK10.92967605
69WNK10.89601934
70PDK20.89387430
71FES0.88420337
72CAMKK20.88384192
73MTOR0.87292844
74DAPK10.84194306
75PRPF4B0.82908192
76BRAF0.81462477
77SGK30.80212337
78STK110.79925612
79TNK20.79854279
80RIPK10.78285228
81CDK150.77641004
82CAMK10.76855747
83CDK140.76181278
84CDK180.75943599
85MAPK150.75704671
86DYRK1B0.74482445
87CAMK2A0.73094073
88PNCK0.71609714
89PTK60.69692424
90DAPK30.68667865
91SGK20.67829878
92LIMK10.67338870
93ERN10.66349507
94SIK20.66201915
95LATS20.65946692
96CDK11A0.65623756
97MAP3K30.65472011
98ILK0.64079945
99PTK20.62818132
100EPHB10.62221826
101MAPK130.61992375
102MARK20.61743501
103PRKG20.61171708
104TNIK0.60835504
105MAP2K10.60546267
106CAMK2D0.59079729
107RPS6KL10.57575036
108RPS6KC10.57575036
109PRKCZ0.57520273
110ROCK20.57083390
111PDGFRA0.56925067
112PAK40.56919389
113MUSK0.56665566
114CAMK2G0.56529176
115EPHB20.56266067
116PLK20.56024428
117MAP2K20.55798660
118AURKA0.54130891
119FER0.52600120
120MAP3K70.50746070
121CAMK2B0.50094886
122ABL20.48756608
123HIPK20.47819585
124CDC42BPA0.46956108
125FGFR40.46524815
126RAF10.45266757
127CAMK1G0.44847765
128MAPKAPK30.44601483
129RPS6KA20.44364804
130WNK30.44333672
131CDK70.44024129
132ROCK10.43640620
133PRKD10.42985207
134TBK10.42887744
135GRK60.42839857
136SCYL20.42710280
137MYLK0.42573912
138CSNK1G20.42410044
139BMX0.41649501
140SGK10.40484901
141MAPK110.40231789
142PAK10.40193550
143MAP2K30.39215483
144VRK20.38742555
145MAP3K80.38739961
146SIK30.37584997
147RPS6KA60.36939294

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.93540704
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.25010766
3Nicotine addiction_Homo sapiens_hsa050332.17673820
4Olfactory transduction_Homo sapiens_hsa047402.16847318
5GABAergic synapse_Homo sapiens_hsa047272.09406979
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.08486189
7Circadian entrainment_Homo sapiens_hsa047132.02413422
8Long-term potentiation_Homo sapiens_hsa047201.96253857
9Glutamatergic synapse_Homo sapiens_hsa047241.89839718
10Insulin secretion_Homo sapiens_hsa049111.84731472
11Notch signaling pathway_Homo sapiens_hsa043301.84539826
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.82996178
13Morphine addiction_Homo sapiens_hsa050321.81099724
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.80696675
15Sulfur relay system_Homo sapiens_hsa041221.80264899
16Nitrogen metabolism_Homo sapiens_hsa009101.79352267
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.73475582
18Amphetamine addiction_Homo sapiens_hsa050311.70883013
19Gastric acid secretion_Homo sapiens_hsa049711.70434652
20Other glycan degradation_Homo sapiens_hsa005111.70306149
21Salivary secretion_Homo sapiens_hsa049701.66983310
22Dopaminergic synapse_Homo sapiens_hsa047281.53595161
23Cholinergic synapse_Homo sapiens_hsa047251.50863829
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.50013085
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49819165
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48970332
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42553577
28Collecting duct acid secretion_Homo sapiens_hsa049661.36177997
29Fructose and mannose metabolism_Homo sapiens_hsa000511.36057460
30Cardiac muscle contraction_Homo sapiens_hsa042601.30506153
31Bladder cancer_Homo sapiens_hsa052191.28592491
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26266708
33Cocaine addiction_Homo sapiens_hsa050301.26171201
34Renin secretion_Homo sapiens_hsa049241.25969637
35Acute myeloid leukemia_Homo sapiens_hsa052211.25778157
36Taste transduction_Homo sapiens_hsa047421.24184242
37Endometrial cancer_Homo sapiens_hsa052131.21065608
38Type II diabetes mellitus_Homo sapiens_hsa049301.16121633
39Oxytocin signaling pathway_Homo sapiens_hsa049211.16076566
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.16056791
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15532964
42GnRH signaling pathway_Homo sapiens_hsa049121.10521602
43Calcium signaling pathway_Homo sapiens_hsa040201.09201316
44Long-term depression_Homo sapiens_hsa047301.07736566
45Bile secretion_Homo sapiens_hsa049761.06076974
46Serotonergic synapse_Homo sapiens_hsa047261.05211937
47Estrogen signaling pathway_Homo sapiens_hsa049151.04996435
48Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04172535
49cAMP signaling pathway_Homo sapiens_hsa040241.03800416
50Gap junction_Homo sapiens_hsa045401.03787106
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02227925
52Non-small cell lung cancer_Homo sapiens_hsa052231.02135424
53Chronic myeloid leukemia_Homo sapiens_hsa052201.01628135
54Biosynthesis of amino acids_Homo sapiens_hsa012301.00758171
55Phenylalanine metabolism_Homo sapiens_hsa003600.99643545
56mTOR signaling pathway_Homo sapiens_hsa041500.96464395
57AMPK signaling pathway_Homo sapiens_hsa041520.95923494
58Glioma_Homo sapiens_hsa052140.94013471
59Vibrio cholerae infection_Homo sapiens_hsa051100.92814250
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91561104
61Pancreatic secretion_Homo sapiens_hsa049720.86930819
62Thyroid hormone synthesis_Homo sapiens_hsa049180.86435801
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85960090
64Pentose phosphate pathway_Homo sapiens_hsa000300.85736301
65Inositol phosphate metabolism_Homo sapiens_hsa005620.85513450
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85440688
67Dorso-ventral axis formation_Homo sapiens_hsa043200.85223338
68Butanoate metabolism_Homo sapiens_hsa006500.85059819
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84849959
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84718872
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84433014
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.83398726
73Glucagon signaling pathway_Homo sapiens_hsa049220.83220874
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.82153740
75Arginine and proline metabolism_Homo sapiens_hsa003300.81968049
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80624876
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.80572264
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78714923
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77277908
80Arginine biosynthesis_Homo sapiens_hsa002200.77038698
81Dilated cardiomyopathy_Homo sapiens_hsa054140.76771526
82Melanogenesis_Homo sapiens_hsa049160.76720097
83Galactose metabolism_Homo sapiens_hsa000520.76713493
84ErbB signaling pathway_Homo sapiens_hsa040120.71592792
85Propanoate metabolism_Homo sapiens_hsa006400.71327992
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69731167
87Endocytosis_Homo sapiens_hsa041440.69130283
88Axon guidance_Homo sapiens_hsa043600.68686165
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68441039
90Vitamin B6 metabolism_Homo sapiens_hsa007500.66551246
91Pyruvate metabolism_Homo sapiens_hsa006200.65220992
92Salmonella infection_Homo sapiens_hsa051320.64791848
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64346943
94Fatty acid metabolism_Homo sapiens_hsa012120.64290682
95Pancreatic cancer_Homo sapiens_hsa052120.62865255
96VEGF signaling pathway_Homo sapiens_hsa043700.62115938
97Insulin signaling pathway_Homo sapiens_hsa049100.59869514
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58978802
99Sphingolipid metabolism_Homo sapiens_hsa006000.58262624
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57172403
101Renin-angiotensin system_Homo sapiens_hsa046140.56252368
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.56168401
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55759233
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55069000
105Rap1 signaling pathway_Homo sapiens_hsa040150.54397611
106Alzheimers disease_Homo sapiens_hsa050100.54077339
107Prion diseases_Homo sapiens_hsa050200.54060685
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53506715
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53218092
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53101006
111Choline metabolism in cancer_Homo sapiens_hsa052310.53059524
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52517547
113Fatty acid biosynthesis_Homo sapiens_hsa000610.52226642
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51982206
115Hepatitis C_Homo sapiens_hsa051600.51844661
116PPAR signaling pathway_Homo sapiens_hsa033200.51813950
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51173145
118Fatty acid degradation_Homo sapiens_hsa000710.51136318
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.50920719
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49618064
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.48054511
122Renal cell carcinoma_Homo sapiens_hsa052110.47252533
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46167867
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.45140479
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44686358
126Oxidative phosphorylation_Homo sapiens_hsa001900.42827263
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.42493694
128MAPK signaling pathway_Homo sapiens_hsa040100.42446992
129Carbon metabolism_Homo sapiens_hsa012000.41546342
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41346610
131Glycerolipid metabolism_Homo sapiens_hsa005610.41311389
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41164256
133Lysosome_Homo sapiens_hsa041420.40287547
134Parkinsons disease_Homo sapiens_hsa050120.39589582
135Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39524398

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