GPR139

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the rhodopsin family of G-protein-coupled receptors. The encoded protein is almost exclusively expressed in the central nervous system. L-tryptophan and L-phenylalanine may act as the physiologic ligands of the encoded protein. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.36964615
2nucleobase catabolic process (GO:0046113)5.82308164
3protein-cofactor linkage (GO:0018065)5.81219287
4dendritic spine morphogenesis (GO:0060997)5.78961006
5erythrocyte maturation (GO:0043249)5.73804826
6cerebellar Purkinje cell layer development (GO:0021680)5.51273085
7vocalization behavior (GO:0071625)5.15538611
8central nervous system projection neuron axonogenesis (GO:0021952)4.65336561
9striatum development (GO:0021756)4.58785146
10neuron cell-cell adhesion (GO:0007158)4.57475866
11layer formation in cerebral cortex (GO:0021819)4.53887629
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.46650324
13neuron recognition (GO:0008038)4.34636572
14synaptic vesicle exocytosis (GO:0016079)4.30918407
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.26232387
16growth hormone secretion (GO:0030252)4.19627833
17establishment of nucleus localization (GO:0040023)4.13252901
18axonal fasciculation (GO:0007413)4.08209249
19negative regulation of microtubule polymerization (GO:0031115)4.07312219
20regulation of synapse structural plasticity (GO:0051823)4.06886157
21neurofilament cytoskeleton organization (GO:0060052)4.06175211
22dendrite morphogenesis (GO:0048813)3.97277624
23protein localization to synapse (GO:0035418)3.93832051
24response to auditory stimulus (GO:0010996)3.89485884
25regulation of synaptic vesicle transport (GO:1902803)3.83746448
26negative regulation of dendrite development (GO:2000171)3.81736104
27granulocyte differentiation (GO:0030851)3.81093722
28positive regulation of synaptic transmission, GABAergic (GO:0032230)3.81086186
29negative regulation of catenin import into nucleus (GO:0035414)3.80966158
30regulation of glutamate receptor signaling pathway (GO:1900449)3.76782769
31positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.76676384
32eating behavior (GO:0042755)3.72724185
33macrophage differentiation (GO:0030225)3.68037078
34positive regulation of synapse assembly (GO:0051965)3.64467548
35regulation of telomere maintenance via telomerase (GO:0032210)3.61745105
36central nervous system neuron axonogenesis (GO:0021955)3.58904395
37clathrin coat assembly (GO:0048268)3.58115237
38regulation of long-term neuronal synaptic plasticity (GO:0048169)3.57392767
39locomotory exploration behavior (GO:0035641)3.55407490
40regulation of short-term neuronal synaptic plasticity (GO:0048172)3.54125146
41proline transport (GO:0015824)3.53573826
42regulation of synaptic vesicle exocytosis (GO:2000300)3.53555976
43synaptic vesicle endocytosis (GO:0048488)3.49100826
44glutamate secretion (GO:0014047)3.47293723
45positive regulation of action potential (GO:0045760)3.46574238
46ionotropic glutamate receptor signaling pathway (GO:0035235)3.42821513
47neurotransmitter-gated ion channel clustering (GO:0072578)3.37540557
48prepulse inhibition (GO:0060134)3.35546932
49transmission of nerve impulse (GO:0019226)3.29712943
50cAMP-mediated signaling (GO:0019933)3.27962101
51G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.27789215
52positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.24762790
53cell migration in hindbrain (GO:0021535)3.24332988
54response to xenobiotic stimulus (GO:0009410)3.19970444
55positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.17753565
56response to misfolded protein (GO:0051788)3.17430508
57homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)3.16976449
58auditory behavior (GO:0031223)3.14401972
59neurotransmitter secretion (GO:0007269)3.14222763
60regulation of neuronal synaptic plasticity (GO:0048168)3.13794796
61regulation of protein kinase A signaling (GO:0010738)3.12045655
62cerebellar Purkinje cell differentiation (GO:0021702)3.11594524
63membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.10090740
64exploration behavior (GO:0035640)3.08951395
65synapse assembly (GO:0007416)3.08903788
66negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05060476
67negative regulation of synaptic transmission, GABAergic (GO:0032229)3.03263809
68synaptic vesicle maturation (GO:0016188)3.03122830
69neuron-neuron synaptic transmission (GO:0007270)3.02870480
70glutamate receptor signaling pathway (GO:0007215)3.00329312
71neuromuscular process controlling posture (GO:0050884)2.98767438
72synaptic transmission, dopaminergic (GO:0001963)2.97632543
73synaptic transmission, glutamatergic (GO:0035249)2.97258152
74dendritic spine organization (GO:0097061)2.95511028
75neuromuscular process controlling balance (GO:0050885)2.94938387
76neuromuscular process (GO:0050905)2.94737704
77dopamine receptor signaling pathway (GO:0007212)2.94583800
78regulation of excitatory postsynaptic membrane potential (GO:0060079)2.94529750
79axon extension (GO:0048675)2.92051006
80synapse organization (GO:0050808)2.91616694
81neuronal action potential propagation (GO:0019227)2.88429047
82positive regulation of synapse maturation (GO:0090129)2.87326233
83regulation of synapse assembly (GO:0051963)2.86759316
84activation of adenylate cyclase activity (GO:0007190)2.85956896
85maternal behavior (GO:0042711)2.85626751
86regulation of postsynaptic membrane potential (GO:0060078)2.85356810
87regulation of dendritic spine morphogenesis (GO:0061001)2.84761636
88membrane hyperpolarization (GO:0060081)2.83301298
89adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.81003824
90presynaptic membrane organization (GO:0097090)2.79907816
91neuron remodeling (GO:0016322)2.78892409
92regulation of synaptic transmission, GABAergic (GO:0032228)2.78760439
93long-term memory (GO:0007616)2.78445774
94detection of temperature stimulus involved in sensory perception (GO:0050961)2.77681661
95detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.77681661
96axonogenesis (GO:0007409)2.76772630
97establishment of synaptic vesicle localization (GO:0097480)2.75227801
98synaptic vesicle transport (GO:0048489)2.75227801
99chaperone-mediated protein transport (GO:0072321)2.74714767
100negative regulation of organelle assembly (GO:1902116)2.74605961

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.90759580
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.35243642
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09726806
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06782346
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.91269481
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.82462932
7TAF15_26573619_Chip-Seq_HEK293_Human2.81411108
8* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.80654478
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.75769184
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68438943
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68438943
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.68005106
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.65309290
14GBX2_23144817_ChIP-Seq_PC3_Human2.62474265
15SUZ12_27294783_Chip-Seq_ESCs_Mouse2.59093830
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.55814485
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53666273
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46959785
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43346467
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43180834
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.42529558
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.41470809
23ZNF274_21170338_ChIP-Seq_K562_Hela2.30637308
24* REST_21632747_ChIP-Seq_MESCs_Mouse2.26980012
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.13975988
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.13347664
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08581352
28RNF2_27304074_Chip-Seq_NSC_Mouse2.00649045
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.94000099
30AR_21572438_ChIP-Seq_LNCaP_Human1.92353256
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.86303497
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82748290
33* CBX2_27304074_Chip-Seq_ESCs_Mouse1.81781958
34* RARB_27405468_Chip-Seq_BRAIN_Mouse1.81222845
35DROSHA_22980978_ChIP-Seq_HELA_Human1.77719983
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.77266164
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.67477839
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64258150
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53218030
40* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50734064
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45072172
42* P300_19829295_ChIP-Seq_ESCs_Human1.43175770
43RING1B_27294783_Chip-Seq_NPCs_Mouse1.33478046
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27360428
45* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27069620
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22710331
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21158232
48* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20984433
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.19539027
50STAT3_23295773_ChIP-Seq_U87_Human1.18404986
51AR_25329375_ChIP-Seq_VCAP_Human1.17701807
52* SOX2_21211035_ChIP-Seq_LN229_Gbm1.17642026
53CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15102785
54RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13641576
55TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12513488
56SMAD4_21799915_ChIP-Seq_A2780_Human1.09630565
57TP53_20018659_ChIP-ChIP_R1E_Mouse1.09019078
58RUNX2_22187159_ChIP-Seq_PCA_Human1.06981387
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06942444
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05880946
61RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05707516
62FUS_26573619_Chip-Seq_HEK293_Human1.05184519
63IGF1R_20145208_ChIP-Seq_DFB_Human1.05025048
64P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04946859
65ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03801574
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03696897
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.01489467
68JUN_21703547_ChIP-Seq_K562_Human1.00828373
69AR_19668381_ChIP-Seq_PC3_Human0.99792520
70* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99455262
71ERG_21242973_ChIP-ChIP_JURKAT_Human0.99041514
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98891650
73NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98800605
74MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98109323
75OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97812146
76NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97186445
77KDM2B_26808549_Chip-Seq_K562_Human0.97027241
78CTCF_27219007_Chip-Seq_Bcells_Human0.95926259
79DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95838468
80KDM2B_26808549_Chip-Seq_REH_Human0.94255015
81YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93586803
82ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91973463
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90441320
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90078273
85CBP_20019798_ChIP-Seq_JUKART_Human0.90078273
86SMAD3_21741376_ChIP-Seq_ESCs_Human0.89167463
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88982676
88ARNT_22903824_ChIP-Seq_MCF-7_Human0.87318470
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84908410
90KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.84284964
91POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83989136
92CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82714574
93* TCF4_23295773_ChIP-Seq_U87_Human0.82325720
94TET1_21490601_ChIP-Seq_MESCs_Mouse0.82196704
95* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81938899
96* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81938899
97TP53_18474530_ChIP-ChIP_U2OS_Human0.80273034
98* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80250119
99EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.79628383
100EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.79498551

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.53709510
2MP0004859_abnormal_synaptic_plasticity4.08564120
3MP0001529_abnormal_vocalization3.89365252
4MP0003122_maternal_imprinting3.88381409
5MP0006276_abnormal_autonomic_nervous3.69226712
6MP0004270_analgesia3.47710437
7MP0003635_abnormal_synaptic_transmissio3.39978330
8MP0009745_abnormal_behavioral_response3.01318115
9MP0000778_abnormal_nervous_system2.86110643
10MP0002063_abnormal_learning/memory/cond2.81188149
11MP0005423_abnormal_somatic_nervous2.81044303
12MP0005645_abnormal_hypothalamus_physiol2.79589504
13MP0003879_abnormal_hair_cell2.73911823
14MP0001968_abnormal_touch/_nociception2.70514468
15MP0001440_abnormal_grooming_behavior2.65053683
16MP0002064_seizures2.56405204
17MP0002572_abnormal_emotion/affect_behav2.46371350
18MP0001486_abnormal_startle_reflex2.33847738
19MP0002184_abnormal_innervation2.28075977
20MP0002734_abnormal_mechanical_nocicepti2.19931405
21MP0002272_abnormal_nervous_system2.11576704
22MP0002733_abnormal_thermal_nociception2.09733421
23MP0002736_abnormal_nociception_after2.02135882
24MP0002735_abnormal_chemical_nociception1.99321282
25MP0009046_muscle_twitch1.98467772
26MP0002822_catalepsy1.97627694
27MP0002909_abnormal_adrenal_gland1.97279834
28MP0002557_abnormal_social/conspecific_i1.90345587
29MP0004185_abnormal_adipocyte_glucose1.81012650
30MP0001970_abnormal_pain_threshold1.80030501
31MP0002067_abnormal_sensory_capabilities1.79310634
32MP0001485_abnormal_pinna_reflex1.74251008
33MP0004924_abnormal_behavior1.71740053
34MP0005386_behavior/neurological_phenoty1.71740053
35MP0003959_abnormal_lean_body1.68291538
36MP0000569_abnormal_digit_pigmentation1.61974152
37MP0003121_genomic_imprinting1.57159881
38MP0003718_maternal_effect1.56012876
39MP0000955_abnormal_spinal_cord1.48814260
40MP0002882_abnormal_neuron_morphology1.48646792
41MP0004811_abnormal_neuron_physiology1.45642926
42MP0001501_abnormal_sleep_pattern1.44268946
43MP0001502_abnormal_circadian_rhythm1.39351543
44MP0003329_amyloid_beta_deposits1.39128255
45MP0001905_abnormal_dopamine_level1.37669820
46MP0002066_abnormal_motor_capabilities/c1.37419081
47MP0005535_abnormal_body_temperature1.33356046
48MP0005646_abnormal_pituitary_gland1.32398534
49MP0001984_abnormal_olfaction1.32188790
50MP0008569_lethality_at_weaning1.27902840
51MP0001188_hyperpigmentation1.25386101
52MP0002152_abnormal_brain_morphology1.20239577
53MP0000751_myopathy1.16686558
54MP0004742_abnormal_vestibular_system1.16654805
55MP0004858_abnormal_nervous_system1.16345622
56MP0002069_abnormal_eating/drinking_beha1.15843724
57MP0003137_abnormal_impulse_conducting1.14534342
58MP0002638_abnormal_pupillary_reflex1.07037835
59MP0002752_abnormal_somatic_nervous1.03748514
60MP0000631_abnormal_neuroendocrine_gland1.02347906
61MP0001299_abnormal_eye_distance/1.02301745
62MP0008961_abnormal_basal_metabolism1.00979471
63MP0004085_abnormal_heartbeat1.00591774
64MP0004142_abnormal_muscle_tone0.94018940
65MP0003861_abnormal_nervous_system0.91511592
66MP0001963_abnormal_hearing_physiology0.89196853
67MP0008995_early_reproductive_senescence0.86188416
68MP0003385_abnormal_body_wall0.86163433
69MP0010030_abnormal_orbit_morphology0.81429849
70MP0000026_abnormal_inner_ear0.78555929
71MP0003948_abnormal_gas_homeostasis0.77902705
72MP0004133_heterotaxia0.76763217
73MP0003633_abnormal_nervous_system0.75708477
74MP0005448_abnormal_energy_balance0.72510318
75MP0002229_neurodegeneration0.72164927
76MP0003631_nervous_system_phenotype0.69500936
77MP0000538_abnormal_urinary_bladder0.68720708
78MP0000371_diluted_coat_color0.68159069
79MP0005452_abnormal_adipose_tissue0.67629462
80MP0010770_preweaning_lethality0.67515635
81MP0002082_postnatal_lethality0.67515635
82MP0002102_abnormal_ear_morphology0.67230655
83MP0010769_abnormal_survival0.65797489
84MP0002837_dystrophic_cardiac_calcinosis0.64575709
85MP0005394_taste/olfaction_phenotype0.64171546
86MP0005499_abnormal_olfactory_system0.64171546
87MP0003634_abnormal_glial_cell0.63846351
88MP0001943_abnormal_respiration0.63668326
89MP0010768_mortality/aging0.61810091
90MP0000920_abnormal_myelination0.61646086
91MP0008874_decreased_physiological_sensi0.61614588
92MP0003953_abnormal_hormone_level0.59547279
93MP0005197_abnormal_uvea_morphology0.59409128
94MP0003956_abnormal_body_size0.56755429
95MP0002081_perinatal_lethality0.56664103
96MP0003172_abnormal_lysosome_physiology0.56128909
97MP0003632_abnormal_nervous_system0.56036723
98MP0003690_abnormal_glial_cell0.55986316
99MP0002751_abnormal_autonomic_nervous0.54805776
100MP0000604_amyloidosis0.53748732

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.55045304
2Visual hallucinations (HP:0002367)8.23185846
3Absence seizures (HP:0002121)7.15514587
4Focal seizures (HP:0007359)6.94446195
5Dialeptic seizures (HP:0011146)5.88894722
6Failure to thrive in infancy (HP:0001531)4.36669420
7Increased serum pyruvate (HP:0003542)4.31364606
8Abnormality of glycolysis (HP:0004366)4.31364606
9Myokymia (HP:0002411)4.31305370
10Polyphagia (HP:0002591)4.01524154
11Generalized tonic-clonic seizures (HP:0002069)3.44872368
12Oligomenorrhea (HP:0000876)3.29080041
13Abnormal eating behavior (HP:0100738)3.17693561
14Aplasia/Hypoplasia of the brainstem (HP:0007362)3.12944394
15Hypoplasia of the brainstem (HP:0002365)3.12944394
16Myopathic facies (HP:0002058)3.02005464
17Aplasia of the musculature (HP:0100854)2.89444479
18Sleep apnea (HP:0010535)2.82053480
19Amyotrophic lateral sclerosis (HP:0007354)2.79944398
20Atonic seizures (HP:0010819)2.79802459
21Limb dystonia (HP:0002451)2.79692326
22Neoplasm of the heart (HP:0100544)2.74707700
23Large eyes (HP:0001090)2.67506622
24Esotropia (HP:0000565)2.63952207
25Poor suck (HP:0002033)2.63001655
26Lissencephaly (HP:0001339)2.62923924
27Fetal akinesia sequence (HP:0001989)2.60971920
28Febrile seizures (HP:0002373)2.58902402
29Rapidly progressive (HP:0003678)2.53031996
30Supranuclear gaze palsy (HP:0000605)2.50992726
31Drooling (HP:0002307)2.45702201
32Excessive salivation (HP:0003781)2.45702201
33Deep palmar crease (HP:0006191)2.44537999
34Palpebral edema (HP:0100540)2.44008845
35Psychosis (HP:0000709)2.43674957
36Torticollis (HP:0000473)2.43291202
37Progressive cerebellar ataxia (HP:0002073)2.39972366
38Hypoventilation (HP:0002791)2.39431489
39Akinesia (HP:0002304)2.38333982
40Mutism (HP:0002300)2.33217122
41Action tremor (HP:0002345)2.32932825
42Ankle clonus (HP:0011448)2.29802016
43Abnormality of the labia minora (HP:0012880)2.29499731
44Anterior segment dysgenesis (HP:0007700)2.27686782
45Concave nail (HP:0001598)2.27009159
46Fair hair (HP:0002286)2.24884044
47Degeneration of anterior horn cells (HP:0002398)2.23926959
48Abnormality of the anterior horn cell (HP:0006802)2.23926959
49Narrow nasal bridge (HP:0000446)2.21022077
50Craniofacial dystonia (HP:0012179)2.20753796
51Depression (HP:0000716)2.20614501
52Blue irides (HP:0000635)2.18652174
53Menstrual irregularities (HP:0000858)2.18175974
54Aplasia/Hypoplasia involving the musculature (HP:0001460)2.17214262
55Focal dystonia (HP:0004373)2.13944715
56Generalized myoclonic seizures (HP:0002123)2.13124093
57Atrophy/Degeneration involving motor neurons (HP:0007373)2.10788661
58Partial agenesis of the corpus callosum (HP:0001338)2.07634161
59Truncal ataxia (HP:0002078)2.07180205
60Broad-based gait (HP:0002136)2.06729386
61Papilledema (HP:0001085)2.05927265
62Heterochromia iridis (HP:0001100)2.05833757
63Postural tremor (HP:0002174)2.04256494
64Progressive inability to walk (HP:0002505)2.04178640
65Abnormality of the lower motor neuron (HP:0002366)2.02603108
66Spinal canal stenosis (HP:0003416)2.02460684
67Pheochromocytoma (HP:0002666)2.00651841
68Severe muscular hypotonia (HP:0006829)1.97517392
69Poor eye contact (HP:0000817)1.96554215
70Specific learning disability (HP:0001328)1.95823941
71Poor speech (HP:0002465)1.95278818
72Iris hypopigmentation (HP:0007730)1.94101875
73Delayed CNS myelination (HP:0002188)1.94019714
74Abnormality of the astrocytes (HP:0100707)1.90826129
75Astrocytoma (HP:0009592)1.90826129
76Spastic gait (HP:0002064)1.89636421
77Inability to walk (HP:0002540)1.89532087
78Lymphangioma (HP:0100764)1.88738781
79Absent speech (HP:0001344)1.88157766
80Agitation (HP:0000713)1.87576463
81Microvesicular hepatic steatosis (HP:0001414)1.86888420
82Postural instability (HP:0002172)1.85151898
83Amblyopia (HP:0000646)1.84362548
84Abnormal social behavior (HP:0012433)1.83563269
85Impaired social interactions (HP:0000735)1.83563269
86Abnormal hair whorl (HP:0010721)1.82728196
87Growth hormone deficiency (HP:0000824)1.81573772
88Shoulder girdle muscle weakness (HP:0003547)1.79952105
89Epileptic encephalopathy (HP:0200134)1.79833428
90Bradycardia (HP:0001662)1.78710984
91Urinary urgency (HP:0000012)1.78559981
92Insidious onset (HP:0003587)1.77252756
93Termporal pattern (HP:0011008)1.77252756
94Neuroendocrine neoplasm (HP:0100634)1.76792361
95Lower limb asymmetry (HP:0100559)1.74867423
96Generalized hypopigmentation of hair (HP:0011358)1.73615162
97Progressive neurologic deterioration (HP:0002344)1.73001851
98Tongue fasciculations (HP:0001308)1.71947337
99Atelectasis (HP:0100750)1.69686554
100Gaze-evoked nystagmus (HP:0000640)1.69174417

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK34.69783984
2MARK14.61016719
3MAP3K124.21986545
4NTRK23.01608557
5MINK12.80377787
6BCR2.74026490
7MAP3K92.45340775
8KSR12.45235267
9FGFR22.41799776
10TYRO32.37924949
11SIK22.14876380
12MAP3K42.05317323
13MAP2K41.97401639
14MAPK131.96488766
15EPHA41.92764198
16NTRK31.90745332
17UHMK11.90513792
18MAP2K71.85156052
19RIPK11.57464062
20VRK11.56692921
21PNCK1.56356653
22CASK1.55638535
23PDGFRA1.51611074
24CDK181.38190299
25PAK31.35575134
26PAK61.31118358
27CSNK1G21.29111212
28EPHB11.27224547
29CDK51.24097099
30CSNK1G31.23802666
31CAMK1G1.22696899
32DDR21.18570728
33TNIK1.17959552
34CDK151.16454843
35FER1.12020019
36DYRK21.11812287
37CDK141.10845680
38PHKG21.10434192
39PHKG11.10434192
40CSNK1A1L1.03939305
41LATS21.03199332
42CDK11A1.02060754
43NTRK10.96926095
44MAP3K110.89066050
45CSNK1G10.83607875
46EPHB20.83542913
47MARK20.82849696
48DAPK20.82333669
49FES0.81492194
50FGFR40.80938649
51KSR20.78583144
52TAOK10.73837687
53LIMK10.72715617
54GRK50.66590835
55RIPK40.65254721
56GRK70.65141526
57IRAK20.64832113
58CAMK2A0.64592590
59RPS6KA20.64173440
60PKN10.63950261
61PRKCE0.60994646
62PRKCG0.60031083
63SRPK10.59236501
64PRKCH0.58628106
65TAOK20.58190520
66CAMK2B0.57859475
67CAMK10.57586967
68MAPK100.57351560
69RET0.56879497
70ERBB30.56400425
71ADRBK20.53971432
72STK110.51941116
73MATK0.51149475
74MAPK40.50549091
75MAP3K50.49813060
76FGFR30.49077331
77WNK30.48701200
78CAMK1D0.48073556
79PRKACG0.47923732
80CAMKK10.47673591
81PRPF4B0.46538994
82PRKACA0.45736146
83ERBB20.45647207
84FYN0.44147918
85FGR0.43838362
86PRKCZ0.42605718
87STK390.41737260
88CAMK40.40644792
89MAPK90.40257661
90CSNK1E0.38895496
91PLK20.38626740
92RPS6KA30.35955498
93STK380.35810183
94PDGFRB0.34975492
95PRKD20.34972221
96DYRK1A0.34014377
97ROCK20.33376481
98SGK2230.31025881
99SGK4940.31025881
100PRKCB0.29341227

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.21192162
2Cocaine addiction_Homo sapiens_hsa050303.01240701
3Synaptic vesicle cycle_Homo sapiens_hsa047212.63539426
4GABAergic synapse_Homo sapiens_hsa047272.61073291
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.49828386
6Axon guidance_Homo sapiens_hsa043602.46083542
7Morphine addiction_Homo sapiens_hsa050322.44803327
8Dopaminergic synapse_Homo sapiens_hsa047282.35769610
9Glutamatergic synapse_Homo sapiens_hsa047242.33107096
10Olfactory transduction_Homo sapiens_hsa047402.28814381
11Insulin secretion_Homo sapiens_hsa049112.22753536
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.21166196
13Circadian entrainment_Homo sapiens_hsa047132.17229310
14Amphetamine addiction_Homo sapiens_hsa050312.10131910
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07042041
16Serotonergic synapse_Homo sapiens_hsa047261.74134067
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69085359
18Cardiac muscle contraction_Homo sapiens_hsa042601.66470982
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65261829
20Long-term potentiation_Homo sapiens_hsa047201.63166113
21Gap junction_Homo sapiens_hsa045401.61762008
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60309973
23Salivary secretion_Homo sapiens_hsa049701.52391415
24Cholinergic synapse_Homo sapiens_hsa047251.50437458
25Nitrogen metabolism_Homo sapiens_hsa009101.43943438
26Taste transduction_Homo sapiens_hsa047421.42092265
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40113382
28GnRH signaling pathway_Homo sapiens_hsa049121.36555167
29Parkinsons disease_Homo sapiens_hsa050121.35802069
30Renin secretion_Homo sapiens_hsa049241.35793461
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33324882
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32038875
33Gastric acid secretion_Homo sapiens_hsa049711.29310329
34Long-term depression_Homo sapiens_hsa047301.27083900
35Calcium signaling pathway_Homo sapiens_hsa040201.22427553
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21760482
37Oxytocin signaling pathway_Homo sapiens_hsa049211.21564539
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.21093402
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10250502
40Alzheimers disease_Homo sapiens_hsa050101.08324755
41Alcoholism_Homo sapiens_hsa050341.01745831
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01099650
43cAMP signaling pathway_Homo sapiens_hsa040241.00327016
44Estrogen signaling pathway_Homo sapiens_hsa049150.99514918
45Oxidative phosphorylation_Homo sapiens_hsa001900.97336266
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97169680
47ErbB signaling pathway_Homo sapiens_hsa040120.96176613
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95304188
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91061144
50Collecting duct acid secretion_Homo sapiens_hsa049660.89267767
51Phototransduction_Homo sapiens_hsa047440.87941259
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83064735
53MAPK signaling pathway_Homo sapiens_hsa040100.81099515
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.79167679
55Melanogenesis_Homo sapiens_hsa049160.77734906
56Choline metabolism in cancer_Homo sapiens_hsa052310.77320478
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75151154
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73673550
59Colorectal cancer_Homo sapiens_hsa052100.73424061
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73321938
61Dilated cardiomyopathy_Homo sapiens_hsa054140.73061716
62Butanoate metabolism_Homo sapiens_hsa006500.72744109
63Thyroid hormone synthesis_Homo sapiens_hsa049180.71254455
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70712482
65Vibrio cholerae infection_Homo sapiens_hsa051100.70316370
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69273247
67Arginine biosynthesis_Homo sapiens_hsa002200.62721668
68Glioma_Homo sapiens_hsa052140.62588550
69Oocyte meiosis_Homo sapiens_hsa041140.61007677
70Type II diabetes mellitus_Homo sapiens_hsa049300.60368994
71Wnt signaling pathway_Homo sapiens_hsa043100.59952186
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.56390006
73Huntingtons disease_Homo sapiens_hsa050160.54645103
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.53393023
75Dorso-ventral axis formation_Homo sapiens_hsa043200.53380950
76Pancreatic secretion_Homo sapiens_hsa049720.53141845
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51640277
78Prion diseases_Homo sapiens_hsa050200.50422561
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50201075
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49573107
81Endometrial cancer_Homo sapiens_hsa052130.48364460
82Viral myocarditis_Homo sapiens_hsa054160.47662332
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47468593
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47398301
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45673049
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44731235
87Rap1 signaling pathway_Homo sapiens_hsa040150.43591390
88Ras signaling pathway_Homo sapiens_hsa040140.43296515
89Renin-angiotensin system_Homo sapiens_hsa046140.42327376
90Basal cell carcinoma_Homo sapiens_hsa052170.41312693
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40881086
92VEGF signaling pathway_Homo sapiens_hsa043700.40599534
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.39796736
94Bile secretion_Homo sapiens_hsa049760.37293180
95Glucagon signaling pathway_Homo sapiens_hsa049220.36477628
96Sulfur relay system_Homo sapiens_hsa041220.35600194
97Type I diabetes mellitus_Homo sapiens_hsa049400.34826438
98Inositol phosphate metabolism_Homo sapiens_hsa005620.33879368
99Endocytosis_Homo sapiens_hsa041440.33463326
100Renal cell carcinoma_Homo sapiens_hsa052110.31784781

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