GPR141

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: GPR141 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.64956540
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.32987921
3positive regulation of gamma-delta T cell activation (GO:0046645)5.77287752
4positive regulation by symbiont of host defense response (GO:0052509)5.75304646
5modulation by symbiont of host defense response (GO:0052031)5.75304646
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.75304646
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.75304646
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.75304646
9modulation by symbiont of host immune response (GO:0052553)5.75304646
10response to peptidoglycan (GO:0032494)5.69306802
11respiratory burst (GO:0045730)5.39771941
12hydrogen peroxide biosynthetic process (GO:0050665)4.93731814
13negative regulation of interleukin-12 production (GO:0032695)4.92013827
14production of molecular mediator involved in inflammatory response (GO:0002532)4.76978183
15superoxide anion generation (GO:0042554)4.76930051
16immunoglobulin mediated immune response (GO:0016064)4.73639107
17neutrophil activation (GO:0042119)4.70083747
18granulocyte activation (GO:0036230)4.68366978
19reactive oxygen species biosynthetic process (GO:1903409)4.65612685
20positive regulation of mast cell activation involved in immune response (GO:0033008)4.59022298
21positive regulation of mast cell degranulation (GO:0043306)4.59022298
22macrophage activation involved in immune response (GO:0002281)4.56859601
23positive regulation of interferon-alpha production (GO:0032727)4.37967079
24negative regulation of cell killing (GO:0031342)4.32592234
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.32592234
26regulation of B cell receptor signaling pathway (GO:0050855)4.27110619
27response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.24090606
28response to host immune response (GO:0052572)4.24090606
29positive regulation of mast cell activation (GO:0033005)4.23880353
30regulation of gamma-delta T cell activation (GO:0046643)4.23698111
31leukocyte aggregation (GO:0070486)4.16885724
32lipopolysaccharide-mediated signaling pathway (GO:0031663)4.15803629
33positive regulation of chemokine biosynthetic process (GO:0045080)4.11332106
34regulation of interferon-alpha production (GO:0032647)4.09825420
35cellular extravasation (GO:0045123)4.02443417
36myeloid cell activation involved in immune response (GO:0002275)3.95837873
37regulation of mast cell degranulation (GO:0043304)3.94973676
38regulation of interferon-beta biosynthetic process (GO:0045357)3.89266155
39positive regulation of monocyte chemotaxis (GO:0090026)3.87210789
40detection of external biotic stimulus (GO:0098581)3.86285904
41regulation of chemokine biosynthetic process (GO:0045073)3.85611518
42positive regulation of cellular amide metabolic process (GO:0034250)3.81491899
43regulation of mast cell activation (GO:0033003)3.74958328
44negative regulation of T cell mediated immunity (GO:0002710)3.72103818
45leukocyte mediated cytotoxicity (GO:0001909)3.71426859
46positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.71077979
47positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.70598052
48response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.70347802
49response to host (GO:0075136)3.70347802
50response to host defenses (GO:0052200)3.70347802
51neutrophil mediated immunity (GO:0002446)3.69327226
52positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.64204999
53regulation of mast cell activation involved in immune response (GO:0033006)3.63478475
54positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.59197725
55cellular response to zinc ion (GO:0071294)3.58543389
56response to muramyl dipeptide (GO:0032495)3.56476705
57regulation of gamma-delta T cell differentiation (GO:0045586)3.52544755
58B cell mediated immunity (GO:0019724)3.52000393
59detection of biotic stimulus (GO:0009595)3.49502233
60type I interferon signaling pathway (GO:0060337)3.48443959
61cellular response to type I interferon (GO:0071357)3.48443959
62regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.47542152
63microglial cell activation (GO:0001774)3.45249139
64negative regulation of lymphocyte mediated immunity (GO:0002707)3.44244242
65response to type I interferon (GO:0034340)3.42954677
66positive regulation of leukocyte degranulation (GO:0043302)3.42674590
67positive regulation of B cell differentiation (GO:0045579)3.42453149
68regulation of myeloid leukocyte mediated immunity (GO:0002886)3.42163993
69defense response to protozoan (GO:0042832)3.41309361
70T-helper 1 type immune response (GO:0042088)3.41156588
71T cell migration (GO:0072678)3.40886680
72positive regulation of toll-like receptor signaling pathway (GO:0034123)3.36487892
73negative regulation of myeloid cell apoptotic process (GO:0033033)3.35762677
74natural killer cell mediated cytotoxicity (GO:0042267)3.35397060
75natural killer cell mediated immunity (GO:0002228)3.35397060
76cellular response to exogenous dsRNA (GO:0071360)3.35083279
77detection of other organism (GO:0098543)3.34738392
78antigen processing and presentation of endogenous antigen (GO:0019883)3.32551790
79regulation of leukocyte degranulation (GO:0043300)3.29898094
80lymphocyte chemotaxis (GO:0048247)3.29458573
81phagosome maturation (GO:0090382)3.28564568
82interferon-gamma-mediated signaling pathway (GO:0060333)3.27831134
83macrophage activation (GO:0042116)3.27786380
84positive regulation of interleukin-1 beta secretion (GO:0050718)3.25821392
85negative regulation of mast cell activation (GO:0033004)3.22643807
86cellular response to interferon-alpha (GO:0035457)3.20263689
87regulation of monocyte chemotaxis (GO:0090025)3.19588231
88negative regulation of cytokine production involved in immune response (GO:0002719)3.17239200
89positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.16554591
90leukocyte migration involved in inflammatory response (GO:0002523)3.14790411
91regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.14242678
92positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.13617820
93detection of molecule of bacterial origin (GO:0032490)3.12002985
94regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.11771572
95antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.10672510
96positive regulation of interferon-beta production (GO:0032728)3.09652822
97neutrophil chemotaxis (GO:0030593)3.08813912
98mast cell activation (GO:0045576)3.07626575
99myeloid dendritic cell differentiation (GO:0043011)3.06737449
100cellular response to interferon-beta (GO:0035458)3.06545125
101myeloid leukocyte activation (GO:0002274)3.05718509
102negative regulation of growth of symbiont in host (GO:0044130)3.05541268
103negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.05541268
104modulation of growth of symbiont involved in interaction with host (GO:0044144)3.05541268
105regulation of growth of symbiont in host (GO:0044126)3.05541268
106regulation of B cell differentiation (GO:0045577)3.05476740
107regulation of antigen processing and presentation (GO:0002577)3.05280301
108activated T cell proliferation (GO:0050798)3.04487298
109response to interferon-alpha (GO:0035455)3.04484355
110positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.04390253
111regulation of hypersensitivity (GO:0002883)3.04366412
112leukocyte degranulation (GO:0043299)3.04167388
113positive regulation of type 2 immune response (GO:0002830)3.03852249
114positive regulation of interleukin-1 secretion (GO:0050716)3.03841112
115positive regulation of antigen processing and presentation (GO:0002579)3.02572880
116regulation of interleukin-1 beta secretion (GO:0050706)3.02572646
117positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.01859176
118negative regulation of leukocyte mediated immunity (GO:0002704)3.00951351
119regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.00701740
120neutrophil migration (GO:1990266)3.00147429
121response to protozoan (GO:0001562)2.99997747
122positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.99531104
123negative regulation of interleukin-6 production (GO:0032715)2.98042980
124detection of bacterium (GO:0016045)2.97778888
125myeloid dendritic cell activation (GO:0001773)2.95771797
126negative regulation of interleukin-17 production (GO:0032700)2.94146741
127regulation of interleukin-17 production (GO:0032660)2.93862794
128regulation of interleukin-8 biosynthetic process (GO:0045414)2.93106649
129positive regulation of heat generation (GO:0031652)2.92909619
130myeloid leukocyte mediated immunity (GO:0002444)2.92818100
131cytokine secretion (GO:0050663)2.92406995
132negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.89775509
133interferon-gamma production (GO:0032609)2.88799952
134positive regulation of interleukin-17 production (GO:0032740)2.86660235
135regulation of alpha-beta T cell proliferation (GO:0046640)2.85886899
136regulation of dendritic cell antigen processing and presentation (GO:0002604)2.85518109
137regulation of interleukin-12 production (GO:0032655)2.84640919

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse7.59054377
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.78226476
3BP1_19119308_ChIP-ChIP_Hs578T_Human6.51072084
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.73921751
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.32791817
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.30726986
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.18335823
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.93983104
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.80770362
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.68853974
11MYB_21317192_ChIP-Seq_ERMYB_Mouse3.62110545
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.25401360
13EGR1_19374776_ChIP-ChIP_THP-1_Human3.04980293
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.02046940
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.89030505
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.84088866
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.72240873
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.69420699
19SPI1_23547873_ChIP-Seq_NB4_Human2.43913488
20* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.37061963
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.32819184
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.04547936
23PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.04051241
24CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.94005706
25PU_27001747_Chip-Seq_BMDM_Mouse1.89714188
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.84219166
27CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.83912872
28SCL_19346495_ChIP-Seq_HPC-7_Human1.80611559
29* MYB_26560356_Chip-Seq_TH2_Human1.79650597
30PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.73202592
31VDR_24763502_ChIP-Seq_THP-1_Human1.71795758
32* RUNX1_22412390_ChIP-Seq_EML_Mouse1.66261965
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62117422
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60254859
35SPI1_23127762_ChIP-Seq_K562_Human1.57531514
36RUNX_20019798_ChIP-Seq_JUKART_Human1.55312858
37CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.54838288
38CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.54551121
39VDR_24787735_ChIP-Seq_THP-1_Human1.53361410
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48576850
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48001960
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.47360421
43PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46984006
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45452761
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39489204
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38556126
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36906372
48MAF_26560356_Chip-Seq_TH1_Human1.35556136
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35360386
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32466329
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31382565
52* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29221603
53MYB_26560356_Chip-Seq_TH1_Human1.28858632
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27594169
55GATA3_26560356_Chip-Seq_TH2_Human1.24936270
56VDR_21846776_ChIP-Seq_THP-1_Human1.23225372
57VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.22507647
58PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21057404
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16344414
60GATA3_27048872_Chip-Seq_THYMUS_Human1.15907804
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13211704
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12783297
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11149217
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.04768031
65GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04024005
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03426780
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02486926
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01293265
69UTX_26944678_Chip-Seq_JUKART_Human1.00041450
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99730062
71EGR1_19032775_ChIP-ChIP_M12_Human0.97213372
72NOTCH1_21737748_ChIP-Seq_TLL_Human0.96341645
73CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95108089
74FLI1_27457419_Chip-Seq_LIVER_Mouse0.90547055
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89637970
76GATA2_21666600_ChIP-Seq_HMVEC_Human0.89560034
77GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.85760257
78E2F7_22180533_ChIP-Seq_HELA_Human0.82628305
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82133746
80GATA1_19941827_ChIP-Seq_MEL_Mouse0.81848134
81SPI1_20517297_ChIP-Seq_HL60_Human0.80055512
82NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79896722
83NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79896722
84GATA1_22025678_ChIP-Seq_K562_Human0.79058165
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.78301102
86SOX2_20726797_ChIP-Seq_SW620_Human0.78256627
87PRDM14_20953172_ChIP-Seq_ESCs_Human0.77969969
88GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75966359
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75902046
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.74775595
91SMRT_27268052_Chip-Seq_Bcells_Human0.74315119
92GATA3_26560356_Chip-Seq_TH1_Human0.74244047
93* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.74220380
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.73484853
95NFE2_27457419_Chip-Seq_LIVER_Mouse0.73378626
96PCGF2_27294783_Chip-Seq_ESCs_Mouse0.73252239
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72997038
98STAT1_20625510_ChIP-Seq_HELA_Human0.72880448
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.72867629
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.72561787
101* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72502978
102EZH2_27294783_Chip-Seq_NPCs_Mouse0.72501293
103ER_23166858_ChIP-Seq_MCF-7_Human0.72342893
104SUZ12_27294783_Chip-Seq_NPCs_Mouse0.72260116
105STAT6_21828071_ChIP-Seq_BEAS2B_Human0.71879635
106ZNF274_21170338_ChIP-Seq_K562_Hela0.69256588
107GATA1_19941827_ChIP-Seq_MEL86_Mouse0.69113749
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67893253
109CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.66726072
110* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64888272
111CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.64738323
112CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.62973482
113GATA2_19941826_ChIP-Seq_K562_Human0.62672392
114TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.62535359
115* TCF7_22412390_ChIP-Seq_EML_Mouse0.61632669
116EGR1_23403033_ChIP-Seq_LIVER_Mouse0.60080237
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.59894262
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.59801299
119SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.59533760
120SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.59533760
121TFEB_21752829_ChIP-Seq_HELA_Human0.59283277
122MAF_26560356_Chip-Seq_TH2_Human0.58962603
123JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.58460379
124TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.57800282
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.57033805
126TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.56644656

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.09172207
2MP0003436_decreased_susceptibility_to4.37166919
3MP0009785_altered_susceptibility_to4.25534898
4MP0002148_abnormal_hypersensitivity_rea4.01302799
5MP0002419_abnormal_innate_immunity3.56047373
6MP0003303_peritoneal_inflammation3.48836018
7MP0005025_abnormal_response_to3.29391312
8MP0005000_abnormal_immune_tolerance3.24203482
9MP0006082_CNS_inflammation3.11202114
10MP0004510_myositis3.10494440
11MP0003724_increased_susceptibility_to2.98595977
12MP0002452_abnormal_antigen_presenting2.74702747
13MP0001790_abnormal_immune_system2.73979084
14MP0005387_immune_system_phenotype2.73979084
15MP0005671_abnormal_response_to2.60448428
16MP0002723_abnormal_immune_serum2.53404958
17MP0001800_abnormal_humoral_immune2.48039852
18MP0000685_abnormal_immune_system2.44310551
19MP0001819_abnormal_immune_cell2.34065387
20MP0002420_abnormal_adaptive_immunity2.29485128
21MP0005464_abnormal_platelet_physiology2.28577299
22MP0005058_abnormal_lysosome_morphology2.28182615
23MP0009764_decreased_sensitivity_to2.25921990
24MP0001533_abnormal_skeleton_physiology2.18088188
25MP0001853_heart_inflammation2.10896885
26MP0001845_abnormal_inflammatory_respons1.99292162
27MP0000343_altered_response_to1.94991562
28MP0003075_altered_response_to1.93072001
29MP0002405_respiratory_system_inflammati1.92220901
30MP0003172_abnormal_lysosome_physiology1.84050623
31MP0003448_altered_tumor_morphology1.73480599
32MP0002006_tumorigenesis1.73001424
33MP0010155_abnormal_intestine_physiology1.69525590
34MP0008469_abnormal_protein_level1.69160430
35MP0004947_skin_inflammation1.67108754
36MP0000569_abnormal_digit_pigmentation1.64012624
37MP0000858_altered_metastatic_potential1.59345242
38MP0000716_abnormal_immune_system1.58274067
39MP0009278_abnormal_bone_marrow1.55058970
40MP0003806_abnormal_nucleotide_metabolis1.49057321
41MP0005174_abnormal_tail_pigmentation1.48197369
42MP0009333_abnormal_splenocyte_physiolog1.48001143
43MP0005310_abnormal_salivary_gland1.47677396
44MP0002398_abnormal_bone_marrow1.44869487
45MP0002998_abnormal_bone_remodeling1.44158111
46MP0005167_abnormal_blood-brain_barrier1.42982349
47MP0005166_decreased_susceptibility_to1.40478991
48MP0003186_abnormal_redox_activity1.31244649
49MP0003183_abnormal_peptide_metabolism1.27877789
50MP0005397_hematopoietic_system_phenotyp1.26372530
51MP0001545_abnormal_hematopoietic_system1.26372530
52MP0003195_calcinosis1.25195725
53MP0005164_abnormal_response_to1.25067914
54MP0002429_abnormal_blood_cell1.24584198
55MP0004782_abnormal_surfactant_physiolog1.24152709
56MP0002132_abnormal_respiratory_system1.19937919
57MP0003191_abnormal_cellular_cholesterol1.18122181
58MP0004858_abnormal_nervous_system1.10287966
59MP0003690_abnormal_glial_cell1.10077883
60MP0008004_abnormal_stomach_pH1.09707140
61MP0000689_abnormal_spleen_morphology1.09455859
62MP0002277_abnormal_respiratory_mucosa1.09410604
63MP0002722_abnormal_immune_system1.05470260
64MP0003828_pulmonary_edema1.04891608
65MP0000604_amyloidosis1.04879095
66MP0001851_eye_inflammation1.04472067
67MP0008260_abnormal_autophagy1.03398943
68MP0005390_skeleton_phenotype1.01963622
69MP0009763_increased_sensitivity_to1.01791104
70MP0002166_altered_tumor_susceptibility1.00966645
71MP0001986_abnormal_taste_sensitivity0.99136297
72MP0002138_abnormal_hepatobiliary_system0.94534532
73MP0000015_abnormal_ear_pigmentation0.91227345
74MP0005075_abnormal_melanosome_morpholog0.90946300
75MP0005076_abnormal_cell_differentiation0.90534145
76MP0000703_abnormal_thymus_morphology0.87163507
77MP0010307_abnormal_tumor_latency0.82301761
78MP0000490_abnormal_crypts_of0.79841436
79MP0003300_gastrointestinal_ulcer0.78973822
80MP0005451_abnormal_body_composition0.77773151
81MP0001501_abnormal_sleep_pattern0.77656760
82MP0000371_diluted_coat_color0.77368312
83MP0000465_gastrointestinal_hemorrhage0.76682053
84MP0002933_joint_inflammation0.74596690
85MP0003045_fibrosis0.73095089
86MP0003566_abnormal_cell_adhesion0.71751068
87MP0006054_spinal_hemorrhage0.70708000
88MP0004808_abnormal_hematopoietic_stem0.69945457
89MP0003795_abnormal_bone_structure0.69174214
90MP0000920_abnormal_myelination0.67460645
91MP0002877_abnormal_melanocyte_morpholog0.65891432
92MP0003656_abnormal_erythrocyte_physiolo0.65410923
93MP0004883_abnormal_blood_vessel0.65260696
94MP0000249_abnormal_blood_vessel0.65250069
95MP0005535_abnormal_body_temperature0.63653648
96MP0005084_abnormal_gallbladder_morpholo0.63317337
97MP0005376_homeostasis/metabolism_phenot0.61278465
98MP0003763_abnormal_thymus_physiology0.59281307
99MP0003866_abnormal_defecation0.58575549
100MP0003646_muscle_fatigue0.57757236
101MP0001764_abnormal_homeostasis0.55753620
102MP0004381_abnormal_hair_follicle0.54496526
103MP0003787_abnormal_imprinting0.53722650
104MP0001663_abnormal_digestive_system0.53083815
105MP0008873_increased_physiological_sensi0.52668160
106MP0000372_irregular_coat_pigmentation0.52284876
107MP0009840_abnormal_foam_cell0.52265789
108MP0004484_altered_response_of0.52002783
109MP0003136_yellow_coat_color0.51346825
110MP0002136_abnormal_kidney_physiology0.49245118
111MP0002254_reproductive_system_inflammat0.48745731
112MP0002332_abnormal_exercise_endurance0.48703254
113MP0003453_abnormal_keratinocyte_physiol0.47734517
114MP0002396_abnormal_hematopoietic_system0.47506900
115MP0005319_abnormal_enzyme/_coenzyme0.45772920
116MP0001873_stomach_inflammation0.44707298
117MP0009765_abnormal_xenobiotic_induced0.44525556
118MP0005584_abnormal_enzyme/coenzyme_acti0.42756443

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)8.61147863
2Eczematoid dermatitis (HP:0000976)8.09417031
3Recurrent bacterial skin infections (HP:0005406)7.95765695
4Recurrent gram-negative bacterial infections (HP:0005420)7.13865739
5Mediastinal lymphadenopathy (HP:0100721)5.66499206
6Abnormality of macrophages (HP:0004311)5.45777376
7Chronic obstructive pulmonary disease (HP:0006510)4.94240777
8Obstructive lung disease (HP:0006536)4.94240777
9Gingivitis (HP:0000230)4.75226619
10Recurrent skin infections (HP:0001581)4.73588301
11Myositis (HP:0100614)4.72480376
12Elevated erythrocyte sedimentation rate (HP:0003565)4.54328602
13Autoimmune thrombocytopenia (HP:0001973)4.51094071
14Orchitis (HP:0100796)4.41373386
15Stomatitis (HP:0010280)4.09117298
16Recurrent fungal infections (HP:0002841)4.06310077
17Retrobulbar optic neuritis (HP:0100654)3.92578678
18Optic neuritis (HP:0100653)3.92578678
19Vasculitis (HP:0002633)3.67862894
20Periodontitis (HP:0000704)3.64447229
21Vacuolated lymphocytes (HP:0001922)3.60056158
22Prostate neoplasm (HP:0100787)3.50647948
23Cellulitis (HP:0100658)3.49666894
24Increased neuronal autofluorescent lipopigment (HP:0002074)3.33702683
25Increased cerebral lipofuscin (HP:0011813)3.32162003
26Urticaria (HP:0001025)3.32035985
27Recurrent viral infections (HP:0004429)3.31116366
28Increased IgM level (HP:0003496)3.30250544
29Pustule (HP:0200039)3.29637773
30Abnormal delayed hypersensitivity skin test (HP:0002963)3.29062758
31Meningitis (HP:0001287)3.18806753
32Thick nail (HP:0001805)3.11291086
33Basal ganglia calcification (HP:0002135)3.09933525
34Disinhibition (HP:0000734)3.05330550
35T lymphocytopenia (HP:0005403)3.05201391
36Recurrent cutaneous fungal infections (HP:0011370)3.02204583
37Chronic mucocutaneous candidiasis (HP:0002728)3.02204583
38Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.96886867
39Pulmonary infiltrates (HP:0002113)2.94273534
40Axonal loss (HP:0003447)2.90296018
41Episodic fever (HP:0001954)2.89905057
42Interstitial pulmonary disease (HP:0006530)2.88632670
43Systemic lupus erythematosus (HP:0002725)2.85881827
44Abnormality of glycolipid metabolism (HP:0010969)2.84305805
45Abnormality of liposaccharide metabolism (HP:0010968)2.84305805
46Abnormality of glycosphingolipid metabolism (HP:0004343)2.84305805
47Keratitis (HP:0000491)2.72857106
48Pulmonary embolism (HP:0002204)2.69799157
49Recurrent pneumonia (HP:0006532)2.68709276
50Hemoptysis (HP:0002105)2.66549113
51Joint hemorrhage (HP:0005261)2.66304381
52Petechiae (HP:0000967)2.66132451
53Abnormality of the prostate (HP:0008775)2.64877000
54Leukocytosis (HP:0001974)2.59612987
55Osteomyelitis (HP:0002754)2.58622259
56Hypergammaglobulinemia (HP:0010702)2.55944892
57Gingival bleeding (HP:0000225)2.55643283
58Keratoconjunctivitis sicca (HP:0001097)2.52048983
59Panhypogammaglobulinemia (HP:0003139)2.50198394
60Polyneuropathy (HP:0001271)2.49932594
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49054712
62Gastrointestinal infarctions (HP:0005244)2.48812295
63Abnormality of T cells (HP:0002843)2.41343693
64Hepatosplenomegaly (HP:0001433)2.36642863
65Recurrent lower respiratory tract infections (HP:0002783)2.36613811
66Agnosia (HP:0010524)2.34663926
67Vertigo (HP:0002321)2.34328431
68Premature loss of primary teeth (HP:0006323)2.29922793
69Arterial thrombosis (HP:0004420)2.29739234
70Tetraparesis (HP:0002273)2.29346017
71Increased IgE level (HP:0003212)2.28445652
72Keratoconjunctivitis (HP:0001096)2.28357052
73Osteolytic defects of the hand bones (HP:0009699)2.27279243
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.27279243
75Abnormality of the pleura (HP:0002103)2.26952778
76Sepsis (HP:0100806)2.26641337
77Poor head control (HP:0002421)2.26313394
78Abnormality of the pericardium (HP:0001697)2.20169276
79Abnormality of iron homeostasis (HP:0011031)2.18329388
80Peritonitis (HP:0002586)2.18108183
81Cheilitis (HP:0100825)2.17160274
82Increased serum ferritin (HP:0003281)2.16952866
83Hematochezia (HP:0002573)2.16179468
84Gangrene (HP:0100758)2.14758099
85Chronic otitis media (HP:0000389)2.13379100
86Myocardial infarction (HP:0001658)2.12571426
87Amaurosis fugax (HP:0100576)2.11806170
88Stomach cancer (HP:0012126)2.10530646
89Skin ulcer (HP:0200042)2.07035267
90Eosinophilia (HP:0001880)2.05622869
91Bone pain (HP:0002653)2.04540655
92Spontaneous hematomas (HP:0007420)2.04297193
93Abnormality of transition element cation homeostasis (HP:0011030)2.03770949
94Epistaxis (HP:0000421)2.03496935
95Glomerulonephritis (HP:0000099)1.99518881
96Abnormality of B cell number (HP:0010975)1.98558743
97Dysostosis multiplex (HP:0000943)1.97687453
98Thrombophlebitis (HP:0004418)1.96908710
99Albinism (HP:0001022)1.96217056
100Purpura (HP:0000979)1.95398087
101Chest pain (HP:0100749)1.95246765
102Neoplasm of head and neck (HP:0012288)1.92166185
103Esophageal neoplasm (HP:0100751)1.92166185
104Abnormality of the endocardium (HP:0004306)1.92096817
105Lower limb hyperreflexia (HP:0002395)1.91659411
106Arthralgia (HP:0002829)1.90752714
107Autoimmune hemolytic anemia (HP:0001890)1.90105859
108Constricted visual fields (HP:0001133)1.88119889
109Amyloidosis (HP:0011034)1.88066882
110Anorexia (HP:0002039)1.87814786
111Abnormal rod and cone electroretinograms (HP:0008323)1.87211430
112Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86557010
113Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86068176
114Nephritis (HP:0000123)1.85121696
115Hypochromic anemia (HP:0001931)1.82494267
116Acne (HP:0001061)1.82248256
117Mutism (HP:0002300)1.81805227
118Glomerulopathy (HP:0100820)1.81653719
119Hypochromic microcytic anemia (HP:0004840)1.80633381
120Loss of speech (HP:0002371)1.79697999
121Abnormality of T cell physiology (HP:0011840)1.79123895
122Abnormality of T cell number (HP:0011839)1.78141089
123Acute hepatic failure (HP:0006554)1.76784017
124Prolonged bleeding time (HP:0003010)1.75171111
125Encephalitis (HP:0002383)1.74723501
126Joint swelling (HP:0001386)1.72846599
127Microcytic anemia (HP:0001935)1.72746676
128Granulocytopenia (HP:0001913)1.71207585
129Inflammation of the large intestine (HP:0002037)1.70241692
130Abnormality of eosinophils (HP:0001879)1.70039082
131Mucopolysacchariduria (HP:0008155)1.68744647

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.35724751
2MAP3K144.23117238
3IRAK44.02777922
4BLK3.31066202
5PBK3.23512759
6TBK12.87450980
7TYK22.73688570
8MAP4K12.67428809
9IRAK32.63163735
10ERN12.34524710
11TXK2.28487072
12IKBKB2.20970969
13MAP3K122.04978902
14IKBKE2.04145623
15KIT2.03327099
16NEK92.02200730
17PIM22.00318761
18JAK31.99606611
19TNK21.96323198
20MAP3K131.90310167
21CSK1.85444423
22JAK11.82156242
23FGR1.62585687
24FRK1.62356896
25SYK1.57906248
26MST41.54617644
27BTK1.50796507
28MAP4K21.50590177
29TEC1.49388165
30LYN1.43179882
31MATK1.40267245
32HCK1.36929005
33TAOK31.36266300
34BMPR21.34500664
35MAP3K61.33672564
36ZAP701.32344543
37CSF1R1.23943358
38ARAF1.20791243
39FES1.16879937
40CDK191.16839804
41DAPK21.12466670
42CHUK1.11988640
43ABL21.11784253
44JAK21.09362992
45CLK11.07786715
46PIM11.07468755
47BMX1.07302565
48YES11.06382833
49MST1R1.04827418
50MAP3K31.02801017
51EIF2AK21.01469059
52LCK0.98902185
53STK40.98019143
54RPS6KA40.97551742
55TRPM70.96834591
56TAOK10.96819940
57ACVR1B0.92831622
58TLK10.91907110
59MAP3K100.91843691
60EPHB10.90870172
61MAP2K40.90024896
62ERBB30.84189468
63NME20.79899197
64PRKCD0.78581263
65MARK30.78458717
66PTK2B0.78181201
67TAOK20.74634094
68NUAK10.73488861
69STK100.72921215
70MAP2K60.71928308
71MAP3K50.66132663
72FGFR30.65865622
73ITK0.65468938
74OXSR10.65141323
75PRPF4B0.64836976
76PINK10.64646746
77SIK20.64480642
78IRAK20.63090428
79ABL10.61230892
80IRAK10.60488455
81RIPK10.59625175
82PRKCQ0.59601737
83GRK70.56499366
84HIPK20.56245989
85MAP2K30.55353489
86STK240.53277043
87PAK40.51786033
88TGFBR20.51438474
89PIK3CG0.49644203
90EGFR0.47991363
91FLT30.45926989
92DYRK30.45655734
93ADRBK10.44115703
94LRRK20.43864093
95WNK10.43769948
96PDK10.42867135
97RPS6KA60.40757654
98PDPK10.40040745
99MYLK0.39138256
100DAPK30.37055120
101EIF2AK10.37049505
102FYN0.36004305
103SGK20.35277845
104STK110.33914807
105CDK60.33783528
106TESK20.32806729
107CAMKK20.32720180
108GRK60.32427339
109MAPKAPK20.32062802
110STK30.32010348
111NLK0.31830761
112FGFR40.30625228
113MARK20.30582395
114RPS6KL10.29717576
115RPS6KC10.29717576
116MAPK70.28836353
117SIK30.28660209
118MOS0.28222068
119EIF2AK30.27650552
120WNK30.27377874
121ADRBK20.27137754
122CAMK40.25219043
123CAMK1D0.25007213
124SGK30.24487671
125DAPK10.24381938
126GRK10.24346118
127MAP3K110.23614167
128MAP3K10.23475623
129TESK10.22692201
130TTN0.22541117
131EPHA30.21802583
132IGF1R0.21578238
133RAF10.20959151
134ILK0.19188387

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.65722260
2Graft-versus-host disease_Homo sapiens_hsa053323.36648400
3Staphylococcus aureus infection_Homo sapiens_hsa051503.10842422
4Legionellosis_Homo sapiens_hsa051342.77736565
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.74419115
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.72196470
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.64837032
8Tuberculosis_Homo sapiens_hsa051522.52837602
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.48709628
10Osteoclast differentiation_Homo sapiens_hsa043802.45880696
11Pertussis_Homo sapiens_hsa051332.35371172
12Rheumatoid arthritis_Homo sapiens_hsa053232.31799037
13Asthma_Homo sapiens_hsa053102.24043187
14Allograft rejection_Homo sapiens_hsa053302.21758584
15Malaria_Homo sapiens_hsa051442.17950461
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.12441033
17Phagosome_Homo sapiens_hsa041452.04877247
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.02872105
19Measles_Homo sapiens_hsa051622.02568324
20Salmonella infection_Homo sapiens_hsa051322.01227985
21Type I diabetes mellitus_Homo sapiens_hsa049401.92665657
22TNF signaling pathway_Homo sapiens_hsa046681.89759157
23Influenza A_Homo sapiens_hsa051641.89260907
24Lysosome_Homo sapiens_hsa041421.83610914
25African trypanosomiasis_Homo sapiens_hsa051431.81621829
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.73183648
27Hematopoietic cell lineage_Homo sapiens_hsa046401.62246088
28Chemokine signaling pathway_Homo sapiens_hsa040621.58494741
29Herpes simplex infection_Homo sapiens_hsa051681.53573125
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.52730410
31B cell receptor signaling pathway_Homo sapiens_hsa046621.45030945
32Toxoplasmosis_Homo sapiens_hsa051451.45000504
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40475583
34Apoptosis_Homo sapiens_hsa042101.40335981
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39719088
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.39162363
37Shigellosis_Homo sapiens_hsa051311.36903582
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21111017
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.18221713
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.12405117
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.09591966
42Antigen processing and presentation_Homo sapiens_hsa046121.09093875
43Other glycan degradation_Homo sapiens_hsa005111.08789605
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04330103
45Hepatitis B_Homo sapiens_hsa051611.01963047
46Viral myocarditis_Homo sapiens_hsa054161.01257966
47Glycosaminoglycan degradation_Homo sapiens_hsa005310.95184785
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93325075
49Amoebiasis_Homo sapiens_hsa051460.90581986
50Autoimmune thyroid disease_Homo sapiens_hsa053200.90321888
51Hepatitis C_Homo sapiens_hsa051600.90289763
52Collecting duct acid secretion_Homo sapiens_hsa049660.87154674
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85608982
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84281833
55Primary immunodeficiency_Homo sapiens_hsa053400.83510321
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82080781
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81897348
58Platelet activation_Homo sapiens_hsa046110.80550782
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77481006
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68583151
61T cell receptor signaling pathway_Homo sapiens_hsa046600.66830988
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65168602
63Complement and coagulation cascades_Homo sapiens_hsa046100.60933179
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59673212
65Acute myeloid leukemia_Homo sapiens_hsa052210.59572552
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.57891398
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57576318
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.54627187
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51697338
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51479479
71Steroid biosynthesis_Homo sapiens_hsa001000.48257024
72Epstein-Barr virus infection_Homo sapiens_hsa051690.47112635
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46734369
74Prion diseases_Homo sapiens_hsa050200.46045266
75Chronic myeloid leukemia_Homo sapiens_hsa052200.42484801
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40629135
77Systemic lupus erythematosus_Homo sapiens_hsa053220.40361227
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40037627
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.39984061
80Pancreatic cancer_Homo sapiens_hsa052120.39961207
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37186516
82Proteasome_Homo sapiens_hsa030500.37034460
83Ether lipid metabolism_Homo sapiens_hsa005650.36943225
84Viral carcinogenesis_Homo sapiens_hsa052030.36597650
85FoxO signaling pathway_Homo sapiens_hsa040680.34285403
86Renin-angiotensin system_Homo sapiens_hsa046140.33780929
87Vibrio cholerae infection_Homo sapiens_hsa051100.33738214
88Sphingolipid metabolism_Homo sapiens_hsa006000.33146167
89Prolactin signaling pathway_Homo sapiens_hsa049170.32848294
90Linoleic acid metabolism_Homo sapiens_hsa005910.32385508
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31906166
92Type II diabetes mellitus_Homo sapiens_hsa049300.31893421
93Phototransduction_Homo sapiens_hsa047440.30712975
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30486622
95HIF-1 signaling pathway_Homo sapiens_hsa040660.30297696
96VEGF signaling pathway_Homo sapiens_hsa043700.27210648
97Mineral absorption_Homo sapiens_hsa049780.26413257
98Non-small cell lung cancer_Homo sapiens_hsa052230.24896362
99Histidine metabolism_Homo sapiens_hsa003400.20586692
100mTOR signaling pathway_Homo sapiens_hsa041500.18988982
101Pentose phosphate pathway_Homo sapiens_hsa000300.18891128
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16496088
103MAPK signaling pathway_Homo sapiens_hsa040100.14255437
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.13743994
105Tryptophan metabolism_Homo sapiens_hsa003800.13707645
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.13365213
107Regulation of autophagy_Homo sapiens_hsa041400.13242095
108Dorso-ventral axis formation_Homo sapiens_hsa043200.12440260
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.12102008
110Choline metabolism in cancer_Homo sapiens_hsa052310.11169270
111Endocytosis_Homo sapiens_hsa041440.10215081
112Insulin resistance_Homo sapiens_hsa049310.09610429
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.09250190
114HTLV-I infection_Homo sapiens_hsa051660.08540392
115Arachidonic acid metabolism_Homo sapiens_hsa005900.08426411
116Small cell lung cancer_Homo sapiens_hsa052220.07831959
117Proteoglycans in cancer_Homo sapiens_hsa052050.07118531
118p53 signaling pathway_Homo sapiens_hsa041150.06206454
119Caffeine metabolism_Homo sapiens_hsa002320.05436774

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