GPR143

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)7.97424450
2maintenance of protein location in nucleus (GO:0051457)7.37988760
3phenol-containing compound biosynthetic process (GO:0046189)7.30577010
4melanocyte differentiation (GO:0030318)7.21549958
5pigment cell differentiation (GO:0050931)7.04164644
6somite rostral/caudal axis specification (GO:0032525)6.95125299
7retinal rod cell development (GO:0046548)6.57185384
8regulation of mammary gland epithelial cell proliferation (GO:0033599)6.54535351
9negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.47233065
10regulation of response to osmotic stress (GO:0047484)6.45165572
11negative regulation of epidermis development (GO:0045683)6.42649606
12developmental pigmentation (GO:0048066)6.41589308
13protein localization to kinetochore (GO:0034501)6.19442564
14regulation of telomere maintenance via telomerase (GO:0032210)6.07045930
15regulation of nuclear cell cycle DNA replication (GO:0033262)6.06545766
16tyrosine metabolic process (GO:0006570)6.01303094
17negative regulation of telomerase activity (GO:0051974)5.97750832
18negative regulation of cell cycle G2/M phase transition (GO:1902750)5.80960596
19regulation of MHC class I biosynthetic process (GO:0045343)5.66945196
20* pigment biosynthetic process (GO:0046148)5.66464813
21negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.64229488
22muscle organ morphogenesis (GO:0048644)5.63097666
23histone H4-K5 acetylation (GO:0043981)5.62415711
24histone H4-K8 acetylation (GO:0043982)5.62415711
25histone H4-K12 acetylation (GO:0043983)5.50704343
26rRNA transcription (GO:0009303)5.49928697
27* melanosome organization (GO:0032438)5.42979227
28ketone body metabolic process (GO:1902224)5.34373443
29secondary metabolic process (GO:0019748)5.22243306
30neuroepithelial cell differentiation (GO:0060563)5.08932743
31* pigment granule organization (GO:0048753)5.08548244
32notochord development (GO:0030903)5.05755339
33negative regulation of epidermal cell differentiation (GO:0045605)5.02509473
34cytidine metabolic process (GO:0046087)5.01561457
35cytidine catabolic process (GO:0006216)5.01561457
36cytidine deamination (GO:0009972)5.01561457
37regulation of cilium movement (GO:0003352)5.00915810
38mitotic sister chromatid segregation (GO:0000070)4.95049744
39response to dietary excess (GO:0002021)4.92970384
40phenol-containing compound catabolic process (GO:0019336)4.90977207
41hormone catabolic process (GO:0042447)4.80941804
42coenzyme catabolic process (GO:0009109)4.80632042
43* pigment metabolic process (GO:0042440)4.74930612
44positive regulation of DNA-dependent DNA replication (GO:2000105)4.72171522
45regulation of apoptotic process involved in morphogenesis (GO:1902337)4.61271119
46rRNA methylation (GO:0031167)4.57221549
47primitive streak formation (GO:0090009)4.56818623
48interferon-gamma production (GO:0032609)4.53276811
49nucleoside transmembrane transport (GO:1901642)4.50116101
50heterochromatin organization (GO:0070828)4.49508404
51quinone metabolic process (GO:1901661)4.49327306
52negative regulation of telomere maintenance (GO:0032205)4.45981721
53protein localization to chromosome, centromeric region (GO:0071459)4.44731283
54cell fate commitment involved in formation of primary germ layer (GO:0060795)4.42968346
55branching involved in mammary gland duct morphogenesis (GO:0060444)4.40641634
56G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.36848489
57proteasome assembly (GO:0043248)4.32824675
58regulation of translation in response to stress (GO:0043555)4.26201314
59cellular modified amino acid catabolic process (GO:0042219)4.17998328
60histone H4-K16 acetylation (GO:0043984)4.15875766
61mitochondrion distribution (GO:0048311)4.13920062
62sister chromatid segregation (GO:0000819)4.09531732
63DNA replication-dependent nucleosome assembly (GO:0006335)4.08813189
64DNA replication-dependent nucleosome organization (GO:0034723)4.08813189
65rRNA modification (GO:0000154)4.08194396
66maintenance of protein localization in organelle (GO:0072595)4.08091861
67chromatin assembly (GO:0031497)4.05543100
68negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)4.00343394
69vitamin A metabolic process (GO:0006776)3.99485738
70nuclear pore complex assembly (GO:0051292)3.95363481
71negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.94382504
72intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.80296324
73positive regulation of protein deacetylation (GO:0090312)3.77426347
74cardiovascular system development (GO:0072358)3.76898753
75DNA replication checkpoint (GO:0000076)3.76833174
76regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.73750495
77tachykinin receptor signaling pathway (GO:0007217)3.73001772
78regulation of telomere maintenance (GO:0032204)3.69587886
79retinoic acid receptor signaling pathway (GO:0048384)3.67012553
80bone trabecula formation (GO:0060346)3.66122291
81pigmentation (GO:0043473)3.63878860
82endosome to melanosome transport (GO:0035646)3.63277363
83endosome to pigment granule transport (GO:0043485)3.63277363
84cullin deneddylation (GO:0010388)3.63216749
85intestinal epithelial cell development (GO:0060576)3.61957122
86regulation of telomerase activity (GO:0051972)3.59247944
87intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.57651089
88microtubule severing (GO:0051013)3.53388202
89pyrimidine ribonucleoside catabolic process (GO:0046133)3.51286923
90icosanoid secretion (GO:0032309)3.50740633
91arachidonic acid secretion (GO:0050482)3.50740633
92pre-miRNA processing (GO:0031054)3.48317290
93positive regulation of histone deacetylation (GO:0031065)3.45854290
94regulation of integrin-mediated signaling pathway (GO:2001044)3.45603185
95epoxygenase P450 pathway (GO:0019373)3.44683556
96proline transport (GO:0015824)3.44259871
97protein polyglutamylation (GO:0018095)3.40538473
98GDP-mannose metabolic process (GO:0019673)3.38125573
99phagocytosis, recognition (GO:0006910)3.36514818
100nuclear pore organization (GO:0006999)3.33704804
101mRNA stabilization (GO:0048255)3.32203898
102RNA stabilization (GO:0043489)3.32203898
103nucleoside transport (GO:0015858)3.31902426
104transepithelial transport (GO:0070633)3.29909061
105maternal placenta development (GO:0001893)3.29742065
106regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.27700417
107negative regulation of JUN kinase activity (GO:0043508)3.25076763
108transcription from mitochondrial promoter (GO:0006390)3.22786400
109CENP-A containing nucleosome assembly (GO:0034080)3.19237797
110regulation of microtubule-based movement (GO:0060632)3.18926205
111cellular response to reactive nitrogen species (GO:1902170)3.18420559
112negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.18229158
113negative regulation of interleukin-2 production (GO:0032703)3.14928433
114protein deneddylation (GO:0000338)3.14883654
115cofactor transport (GO:0051181)3.13598485
116chromatin remodeling at centromere (GO:0031055)3.13029575
117apoptotic DNA fragmentation (GO:0006309)3.12199746
118negative regulation of interleukin-1 beta production (GO:0032691)3.11245571
119anterior/posterior axis specification (GO:0009948)3.10874831
120hypotonic response (GO:0006971)3.09636536
121columnar/cuboidal epithelial cell differentiation (GO:0002065)3.08511499
122detection of temperature stimulus (GO:0016048)3.07786148
123trophectodermal cell differentiation (GO:0001829)3.05699653
124mitotic G2/M transition checkpoint (GO:0044818)3.00924419
125short-chain fatty acid metabolic process (GO:0046459)2.98644951
126kinetochore assembly (GO:0051382)2.94204516
127regulation of DNA endoreduplication (GO:0032875)2.91835277
128regulation of superoxide anion generation (GO:0032928)2.91618597
129synapsis (GO:0007129)2.90486992
130histone exchange (GO:0043486)2.87899345
131regulation of cellular respiration (GO:0043457)2.85530333
132inner mitochondrial membrane organization (GO:0007007)2.84065626
133regulation of mitotic spindle checkpoint (GO:1903504)2.82462998
134regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.82462998
135signal peptide processing (GO:0006465)2.78973465
136mitotic G2 DNA damage checkpoint (GO:0007095)2.78453607
137ventricular cardiac muscle cell development (GO:0055015)2.75659077
138regulation of sister chromatid cohesion (GO:0007063)2.68623113
139regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.68247924
140kinetochore organization (GO:0051383)2.67883231
141negative regulation of DNA-dependent DNA replication (GO:2000104)2.66366998
142anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.64245975
143spindle checkpoint (GO:0031577)2.62266603
144positive regulation of SMAD protein import into nucleus (GO:0060391)2.61976589
145piRNA metabolic process (GO:0034587)2.58111207
146phenol-containing compound metabolic process (GO:0018958)2.58076843
147negative regulation of organelle assembly (GO:1902116)2.57925722
148mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.57780047
149regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.57432861
150replication fork processing (GO:0031297)2.55769804
151establishment of protein localization to mitochondrial membrane (GO:0090151)2.54133387
152detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.48133121
153double-strand break repair via nonhomologous end joining (GO:0006303)2.47430290
154non-recombinational repair (GO:0000726)2.47430290
155mitotic metaphase plate congression (GO:0007080)2.47332218
156platelet dense granule organization (GO:0060155)2.45274527
157negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.44242728
158mitotic spindle checkpoint (GO:0071174)2.41449884
159mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.39905425
160lactate metabolic process (GO:0006089)2.39714758
161chromosome segregation (GO:0007059)2.39574912
162DNA double-strand break processing (GO:0000729)2.38291339
163regulation of chromosome segregation (GO:0051983)2.38225202
164galactose metabolic process (GO:0006012)2.38024918
165negative regulation of interleukin-1 production (GO:0032692)2.37773891
166response to epinephrine (GO:0071871)2.37066809
167centrosome duplication (GO:0051298)2.35273287
168mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.34015551
169metaphase plate congression (GO:0051310)2.33202936
170DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.32082939
171L-serine metabolic process (GO:0006563)2.31853453
172mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.31537152
173mitochondrial respiratory chain complex I assembly (GO:0032981)2.31537152
174NADH dehydrogenase complex assembly (GO:0010257)2.31537152
175DNA replication-independent nucleosome organization (GO:0034724)2.30522445
176DNA replication-independent nucleosome assembly (GO:0006336)2.30522445
177signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.29264849
178signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.29264849
179signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.29264849
180respiratory electron transport chain (GO:0022904)2.28434289
181intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.28139673
182signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.28139673
183telomere maintenance via semi-conservative replication (GO:0032201)2.27015329
184negative regulation of chemokine production (GO:0032682)2.26845496
185establishment of integrated proviral latency (GO:0075713)2.25501533
186cellular response to nitric oxide (GO:0071732)2.24421235
187DNA strand elongation involved in DNA replication (GO:0006271)2.23884058
188melanin biosynthetic process (GO:0042438)19.9099563
189melanin metabolic process (GO:0006582)18.1007337
190secondary metabolite biosynthetic process (GO:0044550)17.1752956
191daunorubicin metabolic process (GO:0044597)12.2471365
192polyketide metabolic process (GO:0030638)12.2471365
193doxorubicin metabolic process (GO:0044598)12.2471365

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.54172589
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse7.01982186
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse7.01982186
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse7.01982186
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.05022450
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.30671521
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.27890843
8E2F7_22180533_ChIP-Seq_HELA_Human3.53355548
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.46176106
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.43228205
11TP63_19390658_ChIP-ChIP_HaCaT_Human3.28370630
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.25844640
13EST1_17652178_ChIP-ChIP_JURKAT_Human3.15952368
14SOX2_18358816_ChIP-ChIP_MESCs_Mouse3.03990232
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.94261550
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.85077752
17SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.76099934
18TCF3_18692474_ChIP-Seq_MESCs_Mouse2.60964632
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58447182
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.52550328
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.50468669
22TCF3_18692474_ChIP-Seq_MEFs_Mouse2.47632231
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.11760180
24ELK1_19687146_ChIP-ChIP_HELA_Human2.11718515
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10600131
26NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.09693016
27NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.06300649
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.02329220
29AR_21909140_ChIP-Seq_LNCAP_Human2.01535117
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.99658184
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99656781
32IRF1_19129219_ChIP-ChIP_H3396_Human1.99178829
33TFEB_21752829_ChIP-Seq_HELA_Human1.94468221
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.93750770
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92043135
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.88073059
37NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.85238401
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78964872
39POU5F1_16518401_ChIP-PET_MESCs_Mouse1.77829439
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77797181
41ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.77421245
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.73010920
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.72236089
44FOXP3_21729870_ChIP-Seq_TREG_Human1.70401193
45TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.68076379
46MYC_18940864_ChIP-ChIP_HL60_Human1.67426753
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65352632
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.64648836
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63487641
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.62725604
51FUS_26573619_Chip-Seq_HEK293_Human1.61051840
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.60147670
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.59386996
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54510678
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52408884
56NANOG_18692474_ChIP-Seq_MESCs_Mouse1.50194798
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.49137839
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.48752445
59CDX2_20551321_ChIP-Seq_CACO-2_Human1.48269084
60PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.46836476
61NANOG_18692474_ChIP-Seq_MEFs_Mouse1.46776720
62E2F1_17053090_ChIP-ChIP_MCF-7_Human1.46588707
63GABP_19822575_ChIP-Seq_HepG2_Human1.45297891
64HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44911467
65VDR_23849224_ChIP-Seq_CD4+_Human1.42960758
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42332569
67POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.41069463
68ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39789316
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39711130
70DCP1A_22483619_ChIP-Seq_HELA_Human1.39394665
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36093110
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34712473
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34218452
74FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33745546
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30418309
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28699697
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27297303
78OCT4_18692474_ChIP-Seq_MEFs_Mouse1.25915382
79* P300_19829295_ChIP-Seq_ESCs_Human1.25904640
80NANOG_16518401_ChIP-PET_MESCs_Mouse1.24349266
81SOX2_18692474_ChIP-Seq_MESCs_Mouse1.23508741
82GATA1_26923725_Chip-Seq_HPCs_Mouse1.21673439
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18764192
84EWS_26573619_Chip-Seq_HEK293_Human1.18176710
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17980443
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15332870
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.13694150
88CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.13648267
89CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12894467
90SOX2_18692474_ChIP-Seq_MEFs_Mouse1.12719974
91MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12472129
92VDR_22108803_ChIP-Seq_LS180_Human1.11220200
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10182581
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.08674155
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07695072
96MYC_22102868_ChIP-Seq_BL_Human1.07549523
97POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06624576
98MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06612561
99AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06294084
100NANOG_16153702_ChIP-ChIP_HESCs_Human1.04825732
101TP53_22127205_ChIP-Seq_IMR90_Human1.02915203
102* MITF_21258399_ChIP-Seq_MELANOMA_Human1.01796594
103MYC_18555785_ChIP-Seq_MESCs_Mouse1.01650028
104ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00990586
105ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00936154
106RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00783289
107* SOX17_20123909_ChIP-Seq_XEN_Mouse1.00701536
108MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99167233
109TTF2_22483619_ChIP-Seq_HELA_Human0.97469049
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97416772
111CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97150819
112SMAD3_21741376_ChIP-Seq_EPCs_Human0.97131889
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96824512
114NCOR1_26117541_ChIP-Seq_K562_Human0.96381635
115POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.95047132
116ZNF274_21170338_ChIP-Seq_K562_Hela0.94879889
117KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94752465
118NANOG_21062744_ChIP-ChIP_HESCs_Human0.94400282
119KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93307079
120POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92538826
121SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90780267
122TBX3_20139965_ChIP-Seq_ESCs_Mouse0.90615543
123ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90461366
124ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90294071
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.89832585
126TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89460286
127EZH2_27294783_Chip-Seq_NPCs_Mouse0.88981299
128ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88438063
129TCF7_22412390_ChIP-Seq_EML_Mouse0.88350070
130ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88086880
131TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87865806
132AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87527104
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86334934
134POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85657707
135EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85356711
136PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84764353
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83764037
138ELF5_23300383_ChIP-Seq_T47D_Human0.83681264
139SMC4_20622854_ChIP-Seq_HELA_Human0.83449143
140STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83072194
141TCF4_22108803_ChIP-Seq_LS180_Human0.82950159
142HOXB7_26014856_ChIP-Seq_BT474_Human0.82823185
143PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82377150
144PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82044183
145FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.81996381
146STAT3_18555785_ChIP-Seq_MESCs_Mouse0.81916509
147IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81018746
148OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78515449
149SCL_19346495_ChIP-Seq_HPC-7_Human0.78488468
150WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.76983786
151MYC_18358816_ChIP-ChIP_MESCs_Mouse0.76418507
152KAP1_27257070_Chip-Seq_ESCs_Mouse0.76000997
153FOXO3_23340844_ChIP-Seq_DLD1_Human0.75016250
154RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.74227314
155KDM2B_26808549_Chip-Seq_K562_Human0.73561518
156CREB1_15753290_ChIP-ChIP_HEK293T_Human0.73067109
157RNF2_27304074_Chip-Seq_NSC_Mouse0.73046697
158KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.72624127
159KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.72199284
160ELK3_25401928_ChIP-Seq_HUVEC_Human0.71426093
161EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.70447935
162SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.70388123
163CTCF_21964334_Chip-Seq_Bcells_Human0.70270466
164YY1_22570637_ChIP-Seq_MALME-3M_Human0.69403073
165RACK7_27058665_Chip-Seq_MCF-7_Human0.69358164
166RING1B_27294783_Chip-Seq_NPCs_Mouse0.69044675
167TP53_20018659_ChIP-ChIP_R1E_Mouse0.66961015
168SOX2_16153702_ChIP-ChIP_HESCs_Human0.66118623
169SPI1_26923725_Chip-Seq_HPCs_Mouse0.65536253
170ELF1_20517297_ChIP-Seq_JURKAT_Human0.62842988
171KLF4_18555785_ChIP-Seq_MESCs_Mouse0.62653990
172KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.62322210
173LXR_22292898_ChIP-Seq_THP-1_Human0.61203642
174STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.61089354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation6.97475284
2MP0005408_hypopigmentation6.10232223
3MP0003011_delayed_dark_adaptation5.48592222
4MP0002254_reproductive_system_inflammat5.21141099
5MP0000015_abnormal_ear_pigmentation4.62257065
6MP0004264_abnormal_extraembryonic_tissu4.50156265
7MP0006292_abnormal_olfactory_placode4.47767361
8MP0002095_abnormal_skin_pigmentation3.71067584
9MP0003890_abnormal_embryonic-extraembry3.65955571
10MP0000371_diluted_coat_color3.52669061
11MP0005499_abnormal_olfactory_system3.44414061
12MP0005394_taste/olfaction_phenotype3.44414061
13MP0004858_abnormal_nervous_system3.42969325
14MP0003122_maternal_imprinting3.17227310
15MP0005257_abnormal_intraocular_pressure3.06133770
16MP0002332_abnormal_exercise_endurance3.00858413
17MP0005174_abnormal_tail_pigmentation2.94578811
18MP0008057_abnormal_DNA_replication2.89157698
19MP0002102_abnormal_ear_morphology2.79123082
20MP0003705_abnormal_hypodermis_morpholog2.67144798
21MP0003878_abnormal_ear_physiology2.67116046
22MP0005377_hearing/vestibular/ear_phenot2.67116046
23MP0004957_abnormal_blastocyst_morpholog2.41553412
24MP0003121_genomic_imprinting2.39448646
25* MP0001324_abnormal_eye_pigmentation2.39056147
26MP0002938_white_spotting2.29613730
27MP0006035_abnormal_mitochondrial_morpho2.28223480
28MP0002075_abnormal_coat/hair_pigmentati2.27307106
29MP0003646_muscle_fatigue2.21933237
30MP0002653_abnormal_ependyma_morphology2.13976764
31MP0002090_abnormal_vision2.13948233
32MP0000678_abnormal_parathyroid_gland2.10978651
33MP0003938_abnormal_ear_development2.00483378
34MP0010352_gastrointestinal_tract_polyps1.97544064
35MP0001186_pigmentation_phenotype1.95599461
36MP0000569_abnormal_digit_pigmentation1.92734894
37MP0008961_abnormal_basal_metabolism1.85839194
38MP0003183_abnormal_peptide_metabolism1.85668210
39MP0005380_embryogenesis_phenotype1.77445126
40MP0001672_abnormal_embryogenesis/_devel1.77445126
41MP0002127_abnormal_cardiovascular_syste1.69363766
42MP0002277_abnormal_respiratory_mucosa1.67072401
43MP0002088_abnormal_embryonic_growth/wei1.66824373
44MP0003984_embryonic_growth_retardation1.64299247
45MP0001849_ear_inflammation1.62206457
46MP0006082_CNS_inflammation1.61952055
47MP0001293_anophthalmia1.57261119
48MP0010030_abnormal_orbit_morphology1.56095287
49MP0004381_abnormal_hair_follicle1.54209037
50MP0002932_abnormal_joint_morphology1.46460762
51MP0002092_abnormal_eye_morphology1.45652613
52MP0000762_abnormal_tongue_morphology1.45184107
53MP0003123_paternal_imprinting1.41834515
54MP0008789_abnormal_olfactory_epithelium1.34136927
55MP0000049_abnormal_middle_ear1.33524021
56MP0003806_abnormal_nucleotide_metabolis1.30691471
57MP0004043_abnormal_pH_regulation1.30081202
58MP0000350_abnormal_cell_proliferation1.27160030
59MP0005248_abnormal_Harderian_gland1.26733367
60MP0005266_abnormal_metabolism1.26533460
61MP0002233_abnormal_nose_morphology1.25408993
62MP0002086_abnormal_extraembryonic_tissu1.23529683
63MP0004885_abnormal_endolymph1.23295739
64MP0002822_catalepsy1.22003876
65MP0005409_darkened_coat_color1.16778778
66MP0001348_abnormal_lacrimal_gland1.14600064
67MP0003787_abnormal_imprinting1.14158814
68MP0002085_abnormal_embryonic_tissue1.14105001
69MP0002114_abnormal_axial_skeleton1.08643465
70MP0010234_abnormal_vibrissa_follicle1.08318648
71MP0003283_abnormal_digestive_organ1.05940423
72MP0003718_maternal_effect1.05881501
73MP0000372_irregular_coat_pigmentation1.05800660
74MP0000432_abnormal_head_morphology1.03948125
75MP0002970_abnormal_white_adipose1.03580433
76MP0003119_abnormal_digestive_system1.03153429
77MP0004133_heterotaxia1.02640030
78MP0003077_abnormal_cell_cycle1.02446057
79MP0002084_abnormal_developmental_patter1.02090110
80* MP0005197_abnormal_uvea_morphology1.01072326
81MP0000428_abnormal_craniofacial_morphol1.01021863
82MP0002396_abnormal_hematopoietic_system1.00337983
83MP0003935_abnormal_craniofacial_develop1.00003073
84MP0003137_abnormal_impulse_conducting0.99005237
85MP0004233_abnormal_muscle_weight0.98472253
86MP0003755_abnormal_palate_morphology0.96906161
87MP0008770_decreased_survivor_rate0.94176153
88* MP0005075_abnormal_melanosome_morpholog0.93620038
89MP0005391_vision/eye_phenotype0.93259225
90MP0006054_spinal_hemorrhage0.91530747
91MP0004197_abnormal_fetal_growth/weight/0.89655700
92MP0002638_abnormal_pupillary_reflex0.88877764
93MP0005508_abnormal_skeleton_morphology0.86911260
94MP0003315_abnormal_perineum_morphology0.84507256
95MP0002132_abnormal_respiratory_system0.82868532
96MP0002925_abnormal_cardiovascular_devel0.81316643
97MP0002249_abnormal_larynx_morphology0.81112958
98MP0000490_abnormal_crypts_of0.80449138
99MP0003136_yellow_coat_color0.80134768
100MP0002751_abnormal_autonomic_nervous0.79561775
101MP0000313_abnormal_cell_death0.77563751
102MP0005551_abnormal_eye_electrophysiolog0.77459680
103MP0000749_muscle_degeneration0.76850904
104MP0003693_abnormal_embryo_hatching0.75800301
105MP0002177_abnormal_outer_ear0.75602386
106MP0000750_abnormal_muscle_regeneration0.75564171
107MP0008058_abnormal_DNA_repair0.75312739
108MP0003172_abnormal_lysosome_physiology0.74743511
109MP0002269_muscular_atrophy0.72412069
110MP0002116_abnormal_craniofacial_bone0.71949163
111MP0005023_abnormal_wound_healing0.70575125
112MP0003111_abnormal_nucleus_morphology0.70514180
113MP0001697_abnormal_embryo_size0.70170975
114MP0002098_abnormal_vibrissa_morphology0.68451124
115MP0009703_decreased_birth_body0.67311683
116MP0003186_abnormal_redox_activity0.66384024
117MP0001730_embryonic_growth_arrest0.66224775
118MP0002080_prenatal_lethality0.64858755
119MP0008932_abnormal_embryonic_tissue0.64324898
120MP0010368_abnormal_lymphatic_system0.62072173
121MP0001286_abnormal_eye_development0.61185955
122MP0003937_abnormal_limbs/digits/tail_de0.60656826
123MP0000647_abnormal_sebaceous_gland0.58953159
124MP0005623_abnormal_meninges_morphology0.58800739
125MP0010094_abnormal_chromosome_stability0.58714631
126MP0002081_perinatal_lethality0.58631837
127MP0005253_abnormal_eye_physiology0.56597386
128MP0000358_abnormal_cell_content/0.56581528
129MP0004883_abnormal_blood_vessel0.56492475
130MP0000383_abnormal_hair_follicle0.56244916
131MP0001270_distended_abdomen0.55859183
132MP0002877_abnormal_melanocyte_morpholog0.54940572
133MP0000377_abnormal_hair_follicle0.54110078
134MP0001984_abnormal_olfaction0.52271642
135MP0001485_abnormal_pinna_reflex0.52100301
136MP0003941_abnormal_skin_development0.50338568
137MP0005187_abnormal_penis_morphology0.45708647
138MP0002089_abnormal_postnatal_growth/wei0.45548936
139MP0000367_abnormal_coat/_hair0.44114972
140MP0003567_abnormal_fetal_cardiomyocyte0.42445116
141MP0008877_abnormal_DNA_methylation0.41610945
142MP0000427_abnormal_hair_cycle0.40856331
143MP0004147_increased_porphyrin_level0.39921847
144MP0001188_hyperpigmentation0.38749738
145MP0006036_abnormal_mitochondrial_physio0.35201809
146MP0005058_abnormal_lysosome_morphology0.35023504
147MP0002229_neurodegeneration0.35010194
148MP0006138_congestive_heart_failure0.33566249
149* MP0005193_abnormal_anterior_eye0.32350101
150MP0003950_abnormal_plasma_membrane0.31352107
151MP0002697_abnormal_eye_size0.30120111
152MP0002210_abnormal_sex_determination0.29379696
153* MP0005195_abnormal_posterior_eye0.27493059
154MP0009046_muscle_twitch0.26373310
155MP0001929_abnormal_gametogenesis0.25980643
156MP0001963_abnormal_hearing_physiology0.24577384
157MP0005386_behavior/neurological_phenoty0.23078284
158MP0004924_abnormal_behavior0.23078284
159MP0008007_abnormal_cellular_replicative0.19601393
160MP0010678_abnormal_skin_adnexa0.19576221
161MP0005395_other_phenotype0.19465452
162MP0003699_abnormal_female_reproductive0.19210534
163MP0003698_abnormal_male_reproductive0.19136367
164MP0000653_abnormal_sex_gland0.18751030
165MP0001915_intracranial_hemorrhage0.18040971
166MP0002161_abnormal_fertility/fecundity0.17361137

Predicted human phenotypes

RankGene SetZ-score
1* Ocular albinism (HP:0001107)8.80342725
2* Iris hypopigmentation (HP:0007730)8.17792153
3White forelock (HP:0002211)7.88137058
4Blue irides (HP:0000635)7.80508983
5Bilateral microphthalmos (HP:0007633)7.79246360
6Patchy hypopigmentation of hair (HP:0011365)7.68269822
7Hypochromic microcytic anemia (HP:0004840)6.76055060
8Generalized hypopigmentation (HP:0007513)6.09509768
9Hepatoblastoma (HP:0002884)6.06302283
10Congenital stationary night blindness (HP:0007642)5.85224907
11Multiple enchondromatosis (HP:0005701)5.30692432
12Abnormality of the lower motor neuron (HP:0002366)5.04384106
13Rib fusion (HP:0000902)4.76114223
14Decreased central vision (HP:0007663)4.68685389
15Albinism (HP:0001022)4.33069822
16Ependymoma (HP:0002888)4.18181054
17Aplasia/Hypoplasia of the fovea (HP:0008060)4.07279857
18Hypoplasia of the fovea (HP:0007750)4.07279857
19Aplasia/Hypoplasia affecting the fundus (HP:0008057)4.00348641
20Abnormal auditory evoked potentials (HP:0006958)3.93969569
21Nephroblastoma (Wilms tumor) (HP:0002667)3.91667633
22Neoplasm of striated muscle (HP:0009728)3.85667218
23Heterochromia iridis (HP:0001100)3.69718244
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.69254801
25Premature graying of hair (HP:0002216)3.67684076
26Rhabdomyosarcoma (HP:0002859)3.64809914
27Testicular atrophy (HP:0000029)3.64735506
28Embryonal renal neoplasm (HP:0011794)3.63376933
29Fused cervical vertebrae (HP:0002949)3.32955080
30Hyperinsulinemic hypoglycemia (HP:0000825)3.25236518
31Generalized hypopigmentation of hair (HP:0011358)3.24403968
32* Freckling (HP:0001480)3.24337400
33Rectovaginal fistula (HP:0000143)3.24326328
34Rectal fistula (HP:0100590)3.24326328
35Partial duplication of thumb phalanx (HP:0009944)3.18662482
36Ragged-red muscle fibers (HP:0003200)3.18045637
37Abnormality of the fovea (HP:0000493)3.14028390
38Anomalous pulmonary venous return (HP:0010772)3.09397509
39Abnormality of the salivary glands (HP:0010286)3.09368405
40Chromsome breakage (HP:0040012)3.08151609
41Congenital sensorineural hearing impairment (HP:0008527)3.04929938
42Amyotrophic lateral sclerosis (HP:0007354)3.03569283
43Abnormality of the astrocytes (HP:0100707)2.97551704
44Astrocytoma (HP:0009592)2.97551704
45Bifid tongue (HP:0010297)2.95999850
46Abnormal cartilage morphology (HP:0002763)2.91028963
47Intestinal fistula (HP:0100819)2.90514412
48Hypoplasia of the iris (HP:0007676)2.88736979
49Aplasia/Hypoplasia of the macula (HP:0008059)2.87312651
50Cutaneous melanoma (HP:0012056)2.85230680
51Aplasia/hypoplasia of the humerus (HP:0006507)2.82935263
52Short humerus (HP:0005792)2.81740438
53Hypochromic anemia (HP:0001931)2.80443256
54Vaginal fistula (HP:0004320)2.80374759
55Abnormal lung lobation (HP:0002101)2.79225418
56Partial duplication of the phalanx of hand (HP:0009999)2.76945039
57Trismus (HP:0000211)2.76106274
58Reduced antithrombin III activity (HP:0001976)2.73907834
59Hyperventilation (HP:0002883)2.66632401
60Abnormality of the pulmonary veins (HP:0011718)2.63879946
61Sensory axonal neuropathy (HP:0003390)2.61225866
62Aplasia/Hypoplasia affecting the retina (HP:0008061)2.60030626
63Pendular nystagmus (HP:0012043)2.58507966
64Generalized hypotonia (HP:0001290)2.56167516
65Shawl scrotum (HP:0000049)2.55943343
66Hypokinesia (HP:0002375)2.55416562
67Preauricular skin tag (HP:0000384)2.54340632
68Large earlobe (HP:0009748)2.53035319
69Periauricular skin pits (HP:0100277)2.52064851
70Preauricular pit (HP:0004467)2.52064851
71Nasolacrimal duct obstruction (HP:0000579)2.44986255
72Hypopigmentation of the fundus (HP:0007894)2.44157604
73Tetraplegia (HP:0002445)2.43110769
74Degeneration of anterior horn cells (HP:0002398)2.39871844
75Abnormality of the anterior horn cell (HP:0006802)2.39871844
76Bilateral sensorineural hearing impairment (HP:0008619)2.39399015
77Abnormality of chromosome segregation (HP:0002916)2.36364115
78Increased connective tissue (HP:0009025)2.35455328
79Difficulty running (HP:0009046)2.34542832
80Progressive muscle weakness (HP:0003323)2.33395186
81Meckel diverticulum (HP:0002245)2.31950909
82Neoplasm of the heart (HP:0100544)2.31013396
83Abnormality of the phalanges of the hallux (HP:0010057)2.29163434
84Intestinal atresia (HP:0011100)2.28631969
85Impulsivity (HP:0100710)2.26280339
86Skin tags (HP:0010609)2.24042015
87Spastic paraparesis (HP:0002313)2.23768858
88Short 5th finger (HP:0009237)2.22917435
89Facial cleft (HP:0002006)2.22895694
90Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.19448829
91Abnormality of small intestinal villus morphology (HP:0011472)2.19237354
92Villous atrophy (HP:0011473)2.19237354
93Abnormality of glycolysis (HP:0004366)2.18999631
94Aplasia/Hypoplasia of the uvula (HP:0010293)2.18962336
95Acute encephalopathy (HP:0006846)2.18604509
96Supernumerary spleens (HP:0009799)2.18517237
97Tongue fasciculations (HP:0001308)2.18030917
98Abnormality of the ileum (HP:0001549)2.16367010
99Abnormality of the musculature of the hand (HP:0001421)2.16279071
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.16047805
101Glioma (HP:0009733)2.14759173
102Upper motor neuron abnormality (HP:0002127)2.13738541
103Malignant neoplasm of the central nervous system (HP:0100836)2.11554146
104Supernumerary nipples (HP:0002558)2.09693757
105Abnormality of the distal phalanx of the thumb (HP:0009617)2.09124414
106Upper limb muscle weakness (HP:0003484)2.08047259
107Abnormality of the pubic bones (HP:0003172)2.06917109
108Renal duplication (HP:0000075)2.05744366
109Abnormality of the intrinsic pathway (HP:0010989)2.03962588
110Abnormal gallbladder physiology (HP:0012438)2.03920732
111Cholecystitis (HP:0001082)2.03920732
112Adrenal hypoplasia (HP:0000835)2.03101989
113Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.02942362
114Glossoptosis (HP:0000162)2.02067094
115Muscle fibrillation (HP:0010546)1.99928387
116Malnutrition (HP:0004395)1.99140025
117Progressive external ophthalmoplegia (HP:0000590)1.98987089
118Pseudobulbar signs (HP:0002200)1.98984425
119Abnormality of liposaccharide metabolism (HP:0010968)1.98600619
120Abnormality of glycosphingolipid metabolism (HP:0004343)1.98600619
121Abnormality of glycolipid metabolism (HP:0010969)1.98600619
122Embryonal neoplasm (HP:0002898)1.98141188
123Cheilitis (HP:0100825)1.97885318
124Aplasia/Hypoplasia of the sternum (HP:0006714)1.97275575
125Skin pits (HP:0100276)1.97188569
126Hand muscle atrophy (HP:0009130)1.95768738
127Microvesicular hepatic steatosis (HP:0001414)1.95037233
128Resting tremor (HP:0002322)1.93664575
129Acute necrotizing encephalopathy (HP:0006965)1.93585793
1303-Methylglutaconic aciduria (HP:0003535)1.93243189
131Skin nodule (HP:0200036)1.89509054
132Abnormality of chromosome stability (HP:0003220)1.87052561
133Neoplasm of the adrenal cortex (HP:0100641)1.83214848
134Increased CSF lactate (HP:0002490)1.82479703
135Abnormal mitochondria in muscle tissue (HP:0008316)1.80414626
136Spinal muscular atrophy (HP:0007269)1.71812209
137Paraparesis (HP:0002385)1.67287823
138Abnormality of methionine metabolism (HP:0010901)1.66115867
139Increased serum pyruvate (HP:0003542)1.65302843
140Median cleft lip (HP:0000161)1.63741215
141Progressive macrocephaly (HP:0004481)1.62198268
142Melanoma (HP:0002861)1.60754613
143Mitochondrial inheritance (HP:0001427)1.59101919
144Neoplasm of the adrenal gland (HP:0100631)1.55021414
145Epidermoid cyst (HP:0200040)1.54541530
146Renal Fanconi syndrome (HP:0001994)1.52569134
147Septo-optic dysplasia (HP:0100842)1.48320351
148Dyschromatopsia (HP:0007641)1.47751849
149Diminished movement (HP:0002374)1.44888568
150* Astigmatism (HP:0000483)1.44833907
151Abnormality of sulfur amino acid metabolism (HP:0004339)1.41874562
152Leukodystrophy (HP:0002415)1.41780300
153Hepatocellular necrosis (HP:0001404)1.41335647
154Duodenal stenosis (HP:0100867)1.41044976
155Small intestinal stenosis (HP:0012848)1.41044976
156Poor head control (HP:0002421)1.40015084
157Gastrointestinal atresia (HP:0002589)1.37587572
158Abnormality of aspartate family amino acid metabolism (HP:0010899)1.37577097
159Peripheral hypomyelination (HP:0007182)1.37154238
160Intrahepatic cholestasis (HP:0001406)1.36865826
161Frequent falls (HP:0002359)1.36279172
162Aplasia/Hypoplasia of the sacrum (HP:0008517)1.35330242
163Birth length less than 3rd percentile (HP:0003561)1.34358439
164Lip pit (HP:0100267)1.33435205
165Increased hepatocellular lipid droplets (HP:0006565)1.32259063
166Aplasia cutis congenita (HP:0001057)1.31200420
167Neoplasm of the colon (HP:0100273)1.29799667
168Decreased electroretinogram (ERG) amplitude (HP:0000654)1.29153719
169Aqueductal stenosis (HP:0002410)1.27401527
170Abnormality of the duodenum (HP:0002246)1.27137781
171Hepatic necrosis (HP:0002605)1.27092894
172Megalencephaly (HP:0001355)1.26381621
173Cerebral hypomyelination (HP:0006808)1.25625644
174Intestinal polyposis (HP:0200008)1.25605948
175Abnormality of the preputium (HP:0100587)1.25344632
176Cerebral edema (HP:0002181)1.25295132
177Morphological abnormality of the inner ear (HP:0011390)1.24588971
178Nasal speech (HP:0001611)1.23457093
179Fibular hypoplasia (HP:0003038)1.20334726
180Lipid accumulation in hepatocytes (HP:0006561)1.20026728
181Type I transferrin isoform profile (HP:0003642)1.18091130
182Spastic diplegia (HP:0001264)1.17840507

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.33977719
2GRK55.58521409
3ERN14.83240123
4GRK64.30118211
5PDK24.27976746
6ADRBK23.29699117
7GRK13.28341475
8TRIM283.11345139
9MARK33.02624435
10TGFBR22.88891023
11CSF1R2.88334174
12TYRO32.82492454
13EIF2AK12.74243665
14BMPR1B2.72399167
15GRK72.61750853
16BUB12.57485743
17MAPK72.53704206
18MATK2.50103767
19TTK2.48864917
20PLK32.37386016
21EIF2AK32.30350184
22MOS2.20705003
23STK102.18954100
24PLK22.13484840
25WNK12.11909148
26CSNK1G31.86011989
27ACVR1B1.85939877
28NTRK11.81271075
29CSNK1G11.79351179
30CSNK1G21.77520427
31PRKCH1.66860686
32MAP3K31.61595013
33CSNK1A1L1.59562305
34NEK11.53151853
35WNK31.50735600
36PRKG21.49848624
37CAMK41.49174137
38CDK71.45064419
39FER1.44998871
40FRK1.44321008
41MARK21.40420071
42MAP2K41.34514531
43MST41.32313884
44HIPK21.24100078
45PAK41.23654668
46FGFR21.23375411
47TSSK61.23235031
48VRK21.21103178
49EPHA21.21066937
50SIK31.20402672
51PBK1.20390529
52BRSK11.19285178
53ADRBK11.14499399
54CHEK21.14314402
55MKNK21.13190650
56FGFR31.12623124
57CDK31.12099423
58BRSK21.11817641
59AKT31.11462744
60STK31.06339283
61TIE11.06307674
62NEK61.05167789
63ZAK0.99961897
64NME20.99457186
65TNIK0.98391779
66STK160.97583489
67MAP3K100.96451687
68ATR0.94119852
69PLK40.93117879
70SRPK10.91998797
71PLK10.91961381
72ERBB30.89433554
73FGR0.83649071
74MAP2K60.81105171
75CSK0.78070410
76LATS10.76937452
77MAPK120.75209332
78MAP3K70.73649029
79AKT20.73039064
80TAF10.72924274
81TGFBR10.72882913
82MKNK10.70537702
83NUAK10.68393789
84FGFR10.68344316
85ALK0.67206090
86EIF2AK20.66110486
87CSNK1D0.65476826
88LATS20.64705091
89CHEK10.64196503
90PTK2B0.63870095
91KDR0.63101411
92MAP3K90.59316520
93BCKDK0.55318773
94STK38L0.54123933
95BCR0.52336161
96PRKAA20.49454866
97MTOR0.47655543
98PTK20.45055186
99VRK10.44640863
100CSNK2A10.44396430
101IGF1R0.42818281
102CDK60.41823764
103ABL20.41196679
104MAP3K120.40989010
105STK390.40581842
106ERBB20.40209989
107BMX0.39681826
108CSNK1A10.39646790
109PDGFRA0.39320728
110ITK0.38903638
111RIPK10.38774048
112PRKD10.38120764
113CDK20.37792055
114NME10.37730924
115PRKCI0.37150851
116CSNK2A20.36465960
117EGFR0.35911423
118NEK20.32214913
119PRKCD0.31751522
120AURKA0.31677015
121CDC70.31090463
122PINK10.30325250
123CSNK1E0.28257822
124MAPK100.28129097
125LMTK20.26927794
126INSR0.26388049
127CAMK2A0.26366878
128PAK10.26361180
129DDR20.25420237
130PRPF4B0.25154091
131PRKD20.24977357
132RPS6KB20.24667853
133SIK20.23480884
134ATM0.23445132
135CDK40.23392138
136IKBKB0.23294056
137GSK3A0.23259270
138MAPK40.19995232
139STK380.19974091
140DYRK1A0.19613777
141PAK30.18914349
142SIK10.18832485
143MAPK10.18802019
144CDK10.18692993
145GSK3B0.18419217
146PRKACG0.17685969
147PRKAA10.17339369
148CDK150.17234506
149WEE10.16313919
150DYRK20.15835527
151MAPK140.15782830
152AURKB0.15420591
153ICK0.15026408
154PRKACB0.14816442
155CDK11A0.14734004
156CDK180.13739678
157MET0.12802301
158TAOK20.12391317
159PRKACA0.11518744
160NTRK20.11265780
161PRKCG0.10550694
162RPS6KA30.10292452
163CDK80.08209921
164PAK60.07195784
165DYRK1B0.06811484
166TAOK10.05709114
167CDK140.05656233
168MAPKAPK30.05244132
169MST1R0.04919969

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.86617873
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006036.81560353
3Fructose and mannose metabolism_Homo sapiens_hsa000514.14318355
4Proteasome_Homo sapiens_hsa030503.64709130
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.63667181
6Non-homologous end-joining_Homo sapiens_hsa034503.24417056
7Tyrosine metabolism_Homo sapiens_hsa003503.12605430
8Arachidonic acid metabolism_Homo sapiens_hsa005902.97559678
9Galactose metabolism_Homo sapiens_hsa000522.86592228
10Protein export_Homo sapiens_hsa030602.80959790
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.60708866
12Oxidative phosphorylation_Homo sapiens_hsa001902.56463133
13Linoleic acid metabolism_Homo sapiens_hsa005912.49642153
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.40799557
15Parkinsons disease_Homo sapiens_hsa050122.31306990
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.12363865
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.07846166
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.94527921
19Basal transcription factors_Homo sapiens_hsa030221.86913596
20Fatty acid elongation_Homo sapiens_hsa000621.80568040
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.80359578
22RNA polymerase_Homo sapiens_hsa030201.79471415
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.74381749
24Propanoate metabolism_Homo sapiens_hsa006401.74119640
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73426591
26Thyroid cancer_Homo sapiens_hsa052161.72330416
27Huntingtons disease_Homo sapiens_hsa050161.72098234
28mTOR signaling pathway_Homo sapiens_hsa041501.66126138
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.62877629
30Glutathione metabolism_Homo sapiens_hsa004801.58623931
31Alzheimers disease_Homo sapiens_hsa050101.49468827
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.42789151
33Pyruvate metabolism_Homo sapiens_hsa006201.40863583
34Base excision repair_Homo sapiens_hsa034101.40007479
35Nucleotide excision repair_Homo sapiens_hsa034201.38155854
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32962542
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.30542722
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.30007091
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.27317805
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25635958
41RNA transport_Homo sapiens_hsa030131.23995013
42Melanogenesis_Homo sapiens_hsa049161.23726773
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21644305
44Fanconi anemia pathway_Homo sapiens_hsa034601.19056539
45Collecting duct acid secretion_Homo sapiens_hsa049661.19006168
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.16621338
47Ovarian steroidogenesis_Homo sapiens_hsa049131.14618545
48mRNA surveillance pathway_Homo sapiens_hsa030151.13401829
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12055940
50Sulfur metabolism_Homo sapiens_hsa009201.09957037
51Chemical carcinogenesis_Homo sapiens_hsa052041.09041139
52Ether lipid metabolism_Homo sapiens_hsa005651.08396955
53Other glycan degradation_Homo sapiens_hsa005111.08321955
54Inositol phosphate metabolism_Homo sapiens_hsa005621.05367845
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04621087
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96433809
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96226791
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94318765
59Pyrimidine metabolism_Homo sapiens_hsa002400.93279050
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.92966677
61Oocyte meiosis_Homo sapiens_hsa041140.92355871
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90019251
63Sphingolipid metabolism_Homo sapiens_hsa006000.89354342
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88787911
65Spliceosome_Homo sapiens_hsa030400.88587793
66Metabolic pathways_Homo sapiens_hsa011000.88463765
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.87657452
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85474939
69Steroid biosynthesis_Homo sapiens_hsa001000.85394077
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82813379
71Choline metabolism in cancer_Homo sapiens_hsa052310.82768702
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82606993
73Cell cycle_Homo sapiens_hsa041100.82370505
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80886794
75One carbon pool by folate_Homo sapiens_hsa006700.80650227
76Basal cell carcinoma_Homo sapiens_hsa052170.79425072
77Pathways in cancer_Homo sapiens_hsa052000.77677670
78N-Glycan biosynthesis_Homo sapiens_hsa005100.76786299
79beta-Alanine metabolism_Homo sapiens_hsa004100.75112757
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75108764
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74985827
82MicroRNAs in cancer_Homo sapiens_hsa052060.74472739
83Rap1 signaling pathway_Homo sapiens_hsa040150.73558970
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71538635
85Fatty acid metabolism_Homo sapiens_hsa012120.71162184
86Purine metabolism_Homo sapiens_hsa002300.70351279
87RNA degradation_Homo sapiens_hsa030180.70200092
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69824714
89Tryptophan metabolism_Homo sapiens_hsa003800.69459110
90Hedgehog signaling pathway_Homo sapiens_hsa043400.69161423
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68791372
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67406786
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66499440
94Fatty acid degradation_Homo sapiens_hsa000710.66212432
95Acute myeloid leukemia_Homo sapiens_hsa052210.65984053
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65751728
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65567634
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.64618165
99Vitamin digestion and absorption_Homo sapiens_hsa049770.63347698
100African trypanosomiasis_Homo sapiens_hsa051430.63338601
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62676036
102Pentose phosphate pathway_Homo sapiens_hsa000300.62578087
103Lysosome_Homo sapiens_hsa041420.60656024
104Prostate cancer_Homo sapiens_hsa052150.59547125
105Vibrio cholerae infection_Homo sapiens_hsa051100.58185210
106p53 signaling pathway_Homo sapiens_hsa041150.57825078
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55479272
108Non-small cell lung cancer_Homo sapiens_hsa052230.54479161
109Folate biosynthesis_Homo sapiens_hsa007900.54233263
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54204607
111Arginine and proline metabolism_Homo sapiens_hsa003300.53465828
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53259152
113Small cell lung cancer_Homo sapiens_hsa052220.51411988
114Phototransduction_Homo sapiens_hsa047440.51255454
115Hippo signaling pathway_Homo sapiens_hsa043900.49381811
116Selenocompound metabolism_Homo sapiens_hsa004500.49210208
117Homologous recombination_Homo sapiens_hsa034400.48838160
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48223032
119Histidine metabolism_Homo sapiens_hsa003400.48136457
120Bladder cancer_Homo sapiens_hsa052190.47493198
121Caffeine metabolism_Homo sapiens_hsa002320.47448746
122Peroxisome_Homo sapiens_hsa041460.47439086
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47371432
124Complement and coagulation cascades_Homo sapiens_hsa046100.46835752
125Taste transduction_Homo sapiens_hsa047420.46299940
126Butanoate metabolism_Homo sapiens_hsa006500.45959203
127Lysine degradation_Homo sapiens_hsa003100.43990063
128AMPK signaling pathway_Homo sapiens_hsa041520.43451285
129Proteoglycans in cancer_Homo sapiens_hsa052050.43120635
130VEGF signaling pathway_Homo sapiens_hsa043700.41058105
131Sulfur relay system_Homo sapiens_hsa041220.39955300
132DNA replication_Homo sapiens_hsa030300.39494826
133Serotonergic synapse_Homo sapiens_hsa047260.38517526
134Ras signaling pathway_Homo sapiens_hsa040140.38187999
135Wnt signaling pathway_Homo sapiens_hsa043100.36860145
136Notch signaling pathway_Homo sapiens_hsa043300.36822622
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.36609788
138Ribosome_Homo sapiens_hsa030100.36593844
139Carbon metabolism_Homo sapiens_hsa012000.36366540
140Vascular smooth muscle contraction_Homo sapiens_hsa042700.34876886
141Cardiac muscle contraction_Homo sapiens_hsa042600.34141485
142Melanoma_Homo sapiens_hsa052180.33837727
143Herpes simplex infection_Homo sapiens_hsa051680.31945912
144Mismatch repair_Homo sapiens_hsa034300.30676337
145Tight junction_Homo sapiens_hsa045300.29482003
146Glutamatergic synapse_Homo sapiens_hsa047240.29188583
147Apoptosis_Homo sapiens_hsa042100.28243970
148PI3K-Akt signaling pathway_Homo sapiens_hsa041510.27690488
149Biosynthesis of amino acids_Homo sapiens_hsa012300.27591717
150Protein digestion and absorption_Homo sapiens_hsa049740.27545618
151Regulation of autophagy_Homo sapiens_hsa041400.27116948
152GnRH signaling pathway_Homo sapiens_hsa049120.26453348
153Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25760341
154TGF-beta signaling pathway_Homo sapiens_hsa043500.25557525
155Pancreatic cancer_Homo sapiens_hsa052120.25365123
156Arginine biosynthesis_Homo sapiens_hsa002200.24952306
157Long-term depression_Homo sapiens_hsa047300.24868633
158Drug metabolism - other enzymes_Homo sapiens_hsa009830.24628887
159Sphingolipid signaling pathway_Homo sapiens_hsa040710.22553978
160Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.22274958
161Adherens junction_Homo sapiens_hsa045200.22236506
162Retinol metabolism_Homo sapiens_hsa008300.19672108
163Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.19366933
164GABAergic synapse_Homo sapiens_hsa047270.18411409
165Bile secretion_Homo sapiens_hsa049760.17978387
166Glycerolipid metabolism_Homo sapiens_hsa005610.17948861
167Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17346663

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