GPR146

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.01931358
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.01931358
3L-phenylalanine metabolic process (GO:0006558)5.79931376
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.79931376
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.49918967
6alpha-linolenic acid metabolic process (GO:0036109)5.49867072
7aromatic amino acid family catabolic process (GO:0009074)5.44101370
8kynurenine metabolic process (GO:0070189)5.06786567
9tryptophan catabolic process (GO:0006569)4.98905051
10indole-containing compound catabolic process (GO:0042436)4.98905051
11indolalkylamine catabolic process (GO:0046218)4.98905051
12hemoglobin metabolic process (GO:0020027)4.91672397
13fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.89600511
14oxygen transport (GO:0015671)4.87340735
15bile acid biosynthetic process (GO:0006699)4.84982674
16lysine catabolic process (GO:0006554)4.84732004
17lysine metabolic process (GO:0006553)4.84732004
18complement activation, alternative pathway (GO:0006957)4.83653663
19glyoxylate metabolic process (GO:0046487)4.81826663
20regulation of protein activation cascade (GO:2000257)4.68837554
21tryptophan metabolic process (GO:0006568)4.66489201
22urea metabolic process (GO:0019627)4.62434613
23urea cycle (GO:0000050)4.62434613
24low-density lipoprotein particle clearance (GO:0034383)4.60095499
25peptidyl-glutamic acid carboxylation (GO:0017187)4.58646235
26protein carboxylation (GO:0018214)4.58646235
27regulation of triglyceride catabolic process (GO:0010896)4.57892166
28cysteine metabolic process (GO:0006534)4.57839465
29sulfur amino acid catabolic process (GO:0000098)4.57331250
30negative regulation of fibrinolysis (GO:0051918)4.56211369
31high-density lipoprotein particle remodeling (GO:0034375)4.48979787
32regulation of complement activation (GO:0030449)4.45097848
33amino-acid betaine metabolic process (GO:0006577)4.38778964
34regulation of fibrinolysis (GO:0051917)4.31205776
35gas transport (GO:0015669)4.27221743
36nitrogen cycle metabolic process (GO:0071941)4.25237664
37positive regulation of gamma-delta T cell activation (GO:0046645)4.23925260
38ethanol oxidation (GO:0006069)4.20344713
39antigen processing and presentation of endogenous antigen (GO:0019883)4.13224840
40reverse cholesterol transport (GO:0043691)4.12112161
41bile acid metabolic process (GO:0008206)4.11201582
42serine family amino acid catabolic process (GO:0009071)4.11135512
43homocysteine metabolic process (GO:0050667)4.08352479
44antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.06106064
45protoporphyrinogen IX metabolic process (GO:0046501)4.03646021
46protein-lipid complex remodeling (GO:0034368)3.99094855
47macromolecular complex remodeling (GO:0034367)3.99094855
48plasma lipoprotein particle remodeling (GO:0034369)3.99094855
49plasma lipoprotein particle clearance (GO:0034381)3.98901843
50alpha-amino acid catabolic process (GO:1901606)3.95446822
51endothelium development (GO:0003158)3.92847810
522-oxoglutarate metabolic process (GO:0006103)3.92495301
53triglyceride homeostasis (GO:0070328)3.92284328
54acylglycerol homeostasis (GO:0055090)3.92284328
55regulation of cholesterol esterification (GO:0010872)3.90858469
56acetyl-CoA metabolic process (GO:0006084)3.88063944
57phospholipid efflux (GO:0033700)3.88038490
58aromatic amino acid family metabolic process (GO:0009072)3.86644398
59cellular ketone body metabolic process (GO:0046950)3.86427424
60antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.85189970
61phospholipid homeostasis (GO:0055091)3.82429973
62dicarboxylic acid biosynthetic process (GO:0043650)3.81178015
63positive regulation of fatty acid beta-oxidation (GO:0032000)3.81096719
64fatty acid beta-oxidation (GO:0006635)3.80879076
65definitive hemopoiesis (GO:0060216)3.79930092
66negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.76641268
67negative regulation of cell killing (GO:0031342)3.76641268
68short-chain fatty acid metabolic process (GO:0046459)3.73883836
69tyrosine metabolic process (GO:0006570)3.72997557
70valine metabolic process (GO:0006573)3.68822995
71carnitine metabolic process (GO:0009437)3.68562076
72coenzyme catabolic process (GO:0009109)3.67422888
73negative regulation of cholesterol transport (GO:0032375)3.66393291
74negative regulation of sterol transport (GO:0032372)3.66393291
75fatty acid oxidation (GO:0019395)3.66388095
76cellular amino acid catabolic process (GO:0009063)3.66146746
77glutamate metabolic process (GO:0006536)3.64649681
78fatty acid transmembrane transport (GO:1902001)3.62329248
79plasma lipoprotein particle assembly (GO:0034377)3.62077350
80lipid oxidation (GO:0034440)3.61791781
81cellular modified amino acid catabolic process (GO:0042219)3.61284519
82triglyceride catabolic process (GO:0019433)3.61181021
83positive regulation of lipid catabolic process (GO:0050996)3.59584036
84aspartate family amino acid catabolic process (GO:0009068)3.59412079
85negative regulation of erythrocyte differentiation (GO:0045647)3.58395110
86regulation of cholesterol homeostasis (GO:2000188)3.56349536
87fatty acid catabolic process (GO:0009062)3.55193278
88regulation of gamma-delta T cell differentiation (GO:0045586)3.49969859
89cholesterol efflux (GO:0033344)3.49680523
90monocarboxylic acid catabolic process (GO:0072329)3.48885826
91antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.47808430
92bile acid and bile salt transport (GO:0015721)3.43704789
93amine catabolic process (GO:0009310)3.41310379
94cellular biogenic amine catabolic process (GO:0042402)3.41310379
95indolalkylamine metabolic process (GO:0006586)3.40823622
96complement activation (GO:0006956)3.40745782
97low-density lipoprotein particle remodeling (GO:0034374)3.40469320
98organic acid catabolic process (GO:0016054)3.40088702
99carboxylic acid catabolic process (GO:0046395)3.40088702
100negative regulation of granulocyte differentiation (GO:0030853)3.39652288
101positive regulation of triglyceride metabolic process (GO:0090208)3.39624127
102complement activation, classical pathway (GO:0006958)3.39562734
103protein activation cascade (GO:0072376)3.36128081
104positive regulation of fatty acid oxidation (GO:0046321)3.35356833
105ketone body metabolic process (GO:1902224)3.34500357
106very-low-density lipoprotein particle assembly (GO:0034379)3.33085624
107regulation of sequestering of triglyceride (GO:0010889)3.31584261
108benzene-containing compound metabolic process (GO:0042537)3.31032023
109positive regulation of lipoprotein lipase activity (GO:0051006)3.30371915
110positive regulation of triglyceride lipase activity (GO:0061365)3.30371915
111regulation of gamma-delta T cell activation (GO:0046643)3.30027085
112cellular glucuronidation (GO:0052695)3.29711843
113protein-lipid complex assembly (GO:0065005)3.29683034
114plasma lipoprotein particle organization (GO:0071827)3.29314459
115cholesterol homeostasis (GO:0042632)3.28970748
116negative regulation of phagocytosis (GO:0050765)3.27843084
117fibrinolysis (GO:0042730)3.26771497
118negative regulation of lipase activity (GO:0060192)3.26463629
119arginine metabolic process (GO:0006525)3.24917788
120detection of other organism (GO:0098543)3.24660214
121detection of bacterium (GO:0016045)3.24656287
122glycine metabolic process (GO:0006544)3.24034365
123protoporphyrinogen IX biosynthetic process (GO:0006782)3.22317707
124acylglycerol catabolic process (GO:0046464)3.20402465
125neutral lipid catabolic process (GO:0046461)3.20402465
126neutrophil activation involved in immune response (GO:0002283)3.10086530
127regulation of platelet aggregation (GO:0090330)3.08258274
128positive thymic T cell selection (GO:0045059)3.00312537
129porphyrin-containing compound biosynthetic process (GO:0006779)2.98383713
130regulation of granulocyte differentiation (GO:0030852)2.97469730
131regulation of macrophage cytokine production (GO:0010935)2.88529129
132positive regulation of B cell differentiation (GO:0045579)2.87838121
133positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.87559701
134cellular response to epinephrine stimulus (GO:0071872)2.87186226
135erythrocyte development (GO:0048821)2.85784857
136heme biosynthetic process (GO:0006783)2.84377262
137regulation of cholesterol storage (GO:0010885)2.81634603
138barbed-end actin filament capping (GO:0051016)2.76899210
139positive regulation of macrophage cytokine production (GO:0060907)2.76811515
140regulation of B cell receptor signaling pathway (GO:0050855)2.76210780
141erythrocyte maturation (GO:0043249)2.74303018
1423-UTR-mediated mRNA stabilization (GO:0070935)2.73537566
143immunoglobulin mediated immune response (GO:0016064)2.72445065
144angiogenesis involved in wound healing (GO:0060055)2.71978495
145response to interleukin-15 (GO:0070672)2.71924865
146mucosal-associated lymphoid tissue development (GO:0048537)2.70884598
147Peyers patch development (GO:0048541)2.70884598
148detection of external biotic stimulus (GO:0098581)2.70754703
149lipid storage (GO:0019915)2.64632569
150regulation of T cell tolerance induction (GO:0002664)2.63794318
151positive regulation of cholesterol efflux (GO:0010875)2.63002729
152negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.62201204
153regulation of mast cell degranulation (GO:0043304)2.61722718
154diacylglycerol metabolic process (GO:0046339)2.59141809
155thymic T cell selection (GO:0045061)2.58735182
156porphyrin-containing compound metabolic process (GO:0006778)2.58173474
157negative T cell selection (GO:0043383)2.56993083
158negative regulation of innate immune response (GO:0045824)2.56950974
159regulation of necroptotic process (GO:0060544)2.55545295
160germinal center formation (GO:0002467)2.54729422
161myeloid cell development (GO:0061515)2.54350502
162negative regulation of lymphocyte mediated immunity (GO:0002707)2.54344682
163negative thymic T cell selection (GO:0045060)2.53960466
164negative regulation of type 2 immune response (GO:0002829)2.53808673
165regulation of myeloid leukocyte mediated immunity (GO:0002886)2.53555633
166tetrapyrrole biosynthetic process (GO:0033014)2.53261529
167positive regulation of tolerance induction (GO:0002645)2.52304824
168negative regulation of necroptotic process (GO:0060546)2.52108510
169blood vessel maturation (GO:0001955)2.52067187
170positive T cell selection (GO:0043368)2.48504177
171negative regulation of leukocyte mediated immunity (GO:0002704)2.47943495
172heme metabolic process (GO:0042168)2.47535705
173T cell selection (GO:0045058)2.44005302
174negative regulation of tumor necrosis factor production (GO:0032720)2.43712890
175regulation of tolerance induction (GO:0002643)2.42643811
176response to peptidoglycan (GO:0032494)2.42615808
177positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.42207206
178positive regulation of vasculogenesis (GO:2001214)2.41999791
179positive regulation of Rap GTPase activity (GO:0032854)2.40691979
180protein kinase C signaling (GO:0070528)2.40274919
181megakaryocyte development (GO:0035855)2.38823529
182negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.38397868
183cellular hyperosmotic response (GO:0071474)2.37926014
184negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.37877966
185regulation of mast cell activation involved in immune response (GO:0033006)2.36543208
186positive regulation of receptor recycling (GO:0001921)2.36401032
187regulation of response to osmotic stress (GO:0047484)2.36270775
188mature B cell differentiation involved in immune response (GO:0002313)2.35764566
189positive regulation of granulocyte differentiation (GO:0030854)2.35505214
190regulation of B cell differentiation (GO:0045577)2.35483580
191positive regulation by organism of defense response of other organism involved in symbiotic interact2.34773211
192modulation by symbiont of host immune response (GO:0052553)2.34773211
193positive regulation by symbiont of host defense response (GO:0052509)2.34773211
194modulation by symbiont of host defense response (GO:0052031)2.34773211
195modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.34773211

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.65355249
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.74883730
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.95350537
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.80670513
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.42775824
6EGR1_23403033_ChIP-Seq_LIVER_Mouse5.06508563
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.53854548
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.66825715
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.51939242
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.70179442
11GATA1_22025678_ChIP-Seq_K562_Human2.64671247
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.63044984
13VDR_21846776_ChIP-Seq_THP-1_Human2.47111863
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31484400
15CLOCK_20551151_ChIP-Seq_293T_Human2.12424462
16KDM2B_26808549_Chip-Seq_DND41_Human2.04859094
17VDR_24763502_ChIP-Seq_THP-1_Human1.98930459
18* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.98209532
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.94493044
20SPI1_23127762_ChIP-Seq_K562_Human1.86572525
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.83635499
22UTX_26944678_Chip-Seq_JUKART_Human1.76105218
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.75946116
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75254702
25RUNX1_22412390_ChIP-Seq_EML_Mouse1.73488158
26MYC_22102868_ChIP-Seq_BL_Human1.72285845
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72044299
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63215323
29* MAF_26560356_Chip-Seq_TH2_Human1.62690492
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58047185
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56214370
32FOXA2_19822575_ChIP-Seq_HepG2_Human1.56002317
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54981522
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.51464363
35* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47651755
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46635559
37CTCF_27219007_Chip-Seq_ERYTHROID_Human1.45557156
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.43335481
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41828277
40* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41290512
41MYB_26560356_Chip-Seq_TH1_Human1.39036786
42* GATA1_19941826_ChIP-Seq_K562_Human1.38457078
43GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37545726
44MYB_26560356_Chip-Seq_TH2_Human1.37187681
45SPI1_23547873_ChIP-Seq_NB4_Human1.35284182
46ELF1_20517297_ChIP-Seq_JURKAT_Human1.33907000
47* BCL6_27268052_Chip-Seq_Bcells_Human1.33186257
48* GATA1_19941827_ChIP-Seq_MEL_Mouse1.26440211
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.25580376
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.25352825
51P68_20966046_ChIP-Seq_HELA_Human1.24906265
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24687193
53KDM2B_26808549_Chip-Seq_K562_Human1.23490229
54* BCOR_27268052_Chip-Seq_Bcells_Human1.20094547
55* KDM2B_26808549_Chip-Seq_JURKAT_Human1.19690304
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.19263973
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.18345793
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17742815
59SCL_19346495_ChIP-Seq_HPC-7_Human1.17586516
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.16920016
61GATA3_27048872_Chip-Seq_THYMUS_Human1.15175393
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15064927
63GATA2_19941826_ChIP-Seq_K562_Human1.13591935
64HNF4A_19822575_ChIP-Seq_HepG2_Human1.12428767
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.11710968
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11508052
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10818396
68NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10529599
69CTCF_21964334_ChIP-Seq_BJAB-B_Human1.10380010
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09081582
71IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08881165
72* TBX20_22080862_ChIP-Seq_HEART_Mouse1.08648378
73* TBX20_22328084_ChIP-Seq_HEART_Mouse1.08648378
74NCOR1_26117541_ChIP-Seq_K562_Human1.07909917
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07292557
76* LXR_22292898_ChIP-Seq_THP-1_Human1.07147140
77IRF8_27001747_Chip-Seq_BMDM_Mouse1.06467219
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05269414
79SPI1_20517297_ChIP-Seq_HL60_Human1.03839349
80SMC4_20622854_ChIP-Seq_HELA_Human1.03706039
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02861202
82PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01290843
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01163079
84* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.99988137
85ZNF263_19887448_ChIP-Seq_K562_Human0.99735789
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98718740
87CTCF_21964334_Chip-Seq_Bcells_Human0.98310979
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95688419
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94964860
90RUNX_20019798_ChIP-Seq_JUKART_Human0.93919400
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93585386
92BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93305553
93* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92654658
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91344067
95SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91291847
96TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90263160
97SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90150788
98FOXO3_23340844_ChIP-Seq_DLD1_Human0.87233994
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86200249
100HTT_18923047_ChIP-ChIP_STHdh_Human0.85396466
101ESR1_20079471_ChIP-ChIP_T-47D_Human0.82978531
102MYB_21317192_ChIP-Seq_ERMYB_Mouse0.82318319
103GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82000851
104PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81967986
105RXRA_24833708_ChIP-Seq_LIVER_Mouse0.81176481
106GATA4_25053715_ChIP-Seq_YYC3_Human0.81117692
107ESR1_21235772_ChIP-Seq_MCF-7_Human0.80443742
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79423352
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77994963
110ELK3_25401928_ChIP-Seq_HUVEC_Human0.76549898
111MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.73596808
112MAF_26560356_Chip-Seq_TH1_Human0.73583065
113* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72956412
114* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.71931836
115GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71881822
116IRF8_21731497_ChIP-ChIP_J774_Mouse0.70755374
117SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.69705436
118* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69195246
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69124851
120* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.67935093
121RACK7_27058665_Chip-Seq_MCF-7_Human0.67436486
122ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.67348064
123ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.65958943
124EGR1_19032775_ChIP-ChIP_M12_Human0.64752141
125PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.64500751
126LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.63977811
127AUTS2_25519132_ChIP-Seq_293T-REX_Human0.61706679
128TCF7_22412390_ChIP-Seq_EML_Mouse0.60853603
129CEBPB_22108803_ChIP-Seq_LS180_Human0.60056105
130TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.59846755
131KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.58952903
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.58614679
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.58614679
134NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57044256
135EP300_21415370_ChIP-Seq_HL-1_Mouse0.56387149
136* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.56330925
137GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.56223296
138* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.55803439
139GATA2_22383799_ChIP-Seq_G1ME_Mouse0.54874273
140FOXA1_25552417_ChIP-Seq_VCAP_Human0.54835815
141* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.54427164
142VDR_24787735_ChIP-Seq_THP-1_Human0.54269360
143PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.54140823

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.44980701
2MP0005360_urolithiasis6.04139469
3MP0005085_abnormal_gallbladder_physiolo5.03901774
4MP0005365_abnormal_bile_salt4.93054958
5MP0008875_abnormal_xenobiotic_pharmacok4.04679085
6MP0009840_abnormal_foam_cell3.28806382
7MP0010329_abnormal_lipoprotein_level3.25825629
8MP0003252_abnormal_bile_duct3.19707496
9MP0003806_abnormal_nucleotide_metabolis3.12191207
10MP0005083_abnormal_biliary_tract2.84374413
11MP0003191_abnormal_cellular_cholesterol2.69451801
12MP0005332_abnormal_amino_acid2.42728315
13MP0005397_hematopoietic_system_phenotyp2.24896790
14MP0001545_abnormal_hematopoietic_system2.24896790
15MP0009278_abnormal_bone_marrow2.23811672
16MP0000609_abnormal_liver_physiology2.07724818
17MP0002118_abnormal_lipid_homeostasis2.05170075
18MP0002138_abnormal_hepatobiliary_system2.03017497
19MP0004130_abnormal_muscle_cell2.00533682
20MP0005670_abnormal_white_adipose1.99060504
21MP0002837_dystrophic_cardiac_calcinosis1.98653684
22MP0003195_calcinosis1.98076950
23MP0001666_abnormal_nutrient_absorption1.91469386
24MP0003656_abnormal_erythrocyte_physiolo1.86602653
25MP0002132_abnormal_respiratory_system1.81599424
26MP0005319_abnormal_enzyme/_coenzyme1.79799124
27MP0005025_abnormal_response_to1.76319098
28MP0008260_abnormal_autophagy1.72427100
29MP0000465_gastrointestinal_hemorrhage1.71494089
30MP0010368_abnormal_lymphatic_system1.70127312
31MP0003763_abnormal_thymus_physiology1.68911871
32MP0003172_abnormal_lysosome_physiology1.67824650
33MP0005000_abnormal_immune_tolerance1.67234730
34MP0009785_altered_susceptibility_to1.62798097
35MP0005584_abnormal_enzyme/coenzyme_acti1.59360003
36MP0005387_immune_system_phenotype1.57776685
37MP0001790_abnormal_immune_system1.57776685
38MP0004019_abnormal_vitamin_homeostasis1.56840094
39MP0002405_respiratory_system_inflammati1.51494647
40MP0002420_abnormal_adaptive_immunity1.48081653
41MP0003724_increased_susceptibility_to1.45671880
42MP0001819_abnormal_immune_cell1.45095614
43MP0001800_abnormal_humoral_immune1.41273804
44MP0001533_abnormal_skeleton_physiology1.38771058
45MP0005671_abnormal_response_to1.38456135
46MP0002723_abnormal_immune_serum1.32793069
47MP0005666_abnormal_adipose_tissue1.30325626
48MP0003705_abnormal_hypodermis_morpholog1.29527333
49MP0009643_abnormal_urine_homeostasis1.29385595
50MP0002398_abnormal_bone_marrow1.29253825
51MP0001764_abnormal_homeostasis1.26812690
52MP0009764_decreased_sensitivity_to1.26481528
53MP0002452_abnormal_antigen_presenting1.22460451
54MP0003868_abnormal_feces_composition1.19758675
55MP0008004_abnormal_stomach_pH1.17815830
56MP0004147_increased_porphyrin_level1.17451458
57MP0002148_abnormal_hypersensitivity_rea1.16971013
58MP0003690_abnormal_glial_cell1.15193888
59MP0003186_abnormal_redox_activity1.14910042
60MP0006082_CNS_inflammation1.14697790
61MP0002254_reproductive_system_inflammat1.14656080
62MP0002933_joint_inflammation1.14387394
63MP0003646_muscle_fatigue1.13576597
64MP0000604_amyloidosis1.12656775
65MP0008469_abnormal_protein_level1.10960383
66MP0000598_abnormal_liver_morphology1.10839389
67MP0009763_increased_sensitivity_to1.10693689
68MP0006036_abnormal_mitochondrial_physio1.09658382
69MP0005451_abnormal_body_composition1.09559643
70MP0000689_abnormal_spleen_morphology1.08696509
71MP0002722_abnormal_immune_system1.08420242
72MP0002970_abnormal_white_adipose1.08351753
73MP0002971_abnormal_brown_adipose1.07384622
74MP0004084_abnormal_cardiac_muscle1.07086128
75MP0003300_gastrointestinal_ulcer1.05467197
76MP0005167_abnormal_blood-brain_barrier1.05361700
77MP0003011_delayed_dark_adaptation1.05089723
78MP0000716_abnormal_immune_system1.03913849
79MP0005464_abnormal_platelet_physiology1.01104755
80MP0001853_heart_inflammation1.00889060
81MP0005058_abnormal_lysosome_morphology1.00042646
82MP0005330_cardiomyopathy0.98922575
83MP0004036_abnormal_muscle_relaxation0.97023718
84MP0004215_abnormal_myocardial_fiber0.95971951
85MP0005647_abnormal_sex_gland0.95280873
86MP0003878_abnormal_ear_physiology0.95038456
87MP0005377_hearing/vestibular/ear_phenot0.95038456
88MP0000003_abnormal_adipose_tissue0.95025430
89MP0002429_abnormal_blood_cell0.94747430
90MP0010155_abnormal_intestine_physiology0.94249516
91MP0004185_abnormal_adipocyte_glucose0.93557984
92MP0009697_abnormal_copulation0.93441214
93MP0005075_abnormal_melanosome_morpholog0.93160235
94MP0005164_abnormal_response_to0.91783649
95MP0004381_abnormal_hair_follicle0.91078078
96MP0005334_abnormal_fat_pad0.90473643
97MP0003436_decreased_susceptibility_to0.90329821
98MP0004947_skin_inflammation0.90117337
99MP0003075_altered_response_to0.88604302
100MP0003866_abnormal_defecation0.87916014
101MP0000343_altered_response_to0.87395279
102MP0004510_myositis0.86182694
103MP0005636_abnormal_mineral_homeostasis0.85545425
104MP0009642_abnormal_blood_homeostasis0.85461400
105MP0005535_abnormal_body_temperature0.83155205
106MP0000703_abnormal_thymus_morphology0.82072241
107MP0001544_abnormal_cardiovascular_syste0.81643030
108MP0005385_cardiovascular_system_phenoty0.81643030
109MP0002078_abnormal_glucose_homeostasis0.81610951
110MP0002998_abnormal_bone_remodeling0.81561303
111MP0001851_eye_inflammation0.81192659
112MP0000858_altered_metastatic_potential0.80640843
113MP0004484_altered_response_of0.80346584
114MP0008775_abnormal_heart_ventricle0.80241249
115MP0005595_abnormal_vascular_smooth0.80111330
116MP0009333_abnormal_splenocyte_physiolog0.80077663
117MP0002166_altered_tumor_susceptibility0.78988571
118MP0005376_homeostasis/metabolism_phenot0.75823519
119MP0005375_adipose_tissue_phenotype0.73137177
120MP0000751_myopathy0.72990938
121MP0003303_peritoneal_inflammation0.72364647
122MP0001879_abnormal_lymphatic_vessel0.72157262
123MP0000249_abnormal_blood_vessel0.70645645
124MP0001756_abnormal_urination0.70153138
125MP0002972_abnormal_cardiac_muscle0.69540646
126MP0000749_muscle_degeneration0.69307503
127MP0006138_congestive_heart_failure0.68643698
128MP0010630_abnormal_cardiac_muscle0.67757937
129MP0004087_abnormal_muscle_fiber0.67545875
130MP0005166_decreased_susceptibility_to0.67136623
131MP0002269_muscular_atrophy0.66208944
132MP0005165_increased_susceptibility_to0.65992195
133MP0009115_abnormal_fat_cell0.63805885
134MP0002419_abnormal_innate_immunity0.63143767
135MP0000230_abnormal_systemic_arterial0.62968709
136MP0001661_extended_life_span0.62945397
137MP0003329_amyloid_beta_deposits0.62671307
138MP0002136_abnormal_kidney_physiology0.62096501
139MP0002332_abnormal_exercise_endurance0.62078903
140MP0009765_abnormal_xenobiotic_induced0.61703472
141MP0005266_abnormal_metabolism0.61308980
142MP0001835_abnormal_antigen_presentation0.61082619
143MP0009384_cardiac_valve_regurgitation0.58168569
144MP0008874_decreased_physiological_sensi0.57294014
145MP0003828_pulmonary_edema0.55979296
146MP0000685_abnormal_immune_system0.55786549
147MP0004782_abnormal_surfactant_physiolog0.55705294
148MP0001845_abnormal_inflammatory_respons0.55683264

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)6.37796847
2Deep venous thrombosis (HP:0002625)6.12177988
3Intrahepatic cholestasis (HP:0001406)5.61689488
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.55461539
5Xanthomatosis (HP:0000991)5.46794834
6Hyperlipoproteinemia (HP:0010980)5.24876471
7Complement deficiency (HP:0004431)5.21794996
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.92068903
9Prolonged partial thromboplastin time (HP:0003645)4.87952268
10Hypochromic anemia (HP:0001931)4.59157753
11Microcytic anemia (HP:0001935)4.51269594
12Hypobetalipoproteinemia (HP:0003563)4.35660175
13Hyperammonemia (HP:0001987)4.28074741
14Ketosis (HP:0001946)4.23648917
15Hypoalphalipoproteinemia (HP:0003233)4.20710920
16Joint hemorrhage (HP:0005261)4.08812433
17Hypoglycemic coma (HP:0001325)4.01962583
18Hypolipoproteinemia (HP:0010981)4.00155910
19Hyperglycinuria (HP:0003108)3.85201035
20Abnormality of complement system (HP:0005339)3.82633968
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.79857048
22Epidermoid cyst (HP:0200040)3.65251995
23Myositis (HP:0100614)3.63316191
24Abnormality of glycine metabolism (HP:0010895)3.60751309
25Abnormality of serine family amino acid metabolism (HP:0010894)3.60751309
26Abnormality of the common coagulation pathway (HP:0010990)3.60545341
27Abnormality of fatty-acid metabolism (HP:0004359)3.53851458
28Elevated erythrocyte sedimentation rate (HP:0003565)3.49539225
29Ketoacidosis (HP:0001993)3.49324266
30Prolonged bleeding time (HP:0003010)3.46718387
31Hyperglycinemia (HP:0002154)3.45471200
32Abnormal hemoglobin (HP:0011902)3.44844946
33Eczematoid dermatitis (HP:0000976)3.44179939
34Systemic lupus erythematosus (HP:0002725)3.43589362
35Abnormality of glutamine family amino acid metabolism (HP:0010902)3.37468070
36Abnormality of sulfur amino acid metabolism (HP:0004339)3.34847442
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.28683178
38Hypercholesterolemia (HP:0003124)3.18447947
39Abnormality of aspartate family amino acid metabolism (HP:0010899)3.18352519
40Abnormality of methionine metabolism (HP:0010901)3.15847808
41Difficulty running (HP:0009046)3.11486914
42Myocardial infarction (HP:0001658)3.10499233
43Increased variability in muscle fiber diameter (HP:0003557)3.07042802
44Abnormality of the intrinsic pathway (HP:0010989)3.05663049
45Orchitis (HP:0100796)3.04456133
46Hyperbilirubinemia (HP:0002904)3.01769719
47Colitis (HP:0002583)2.98813869
48Fat malabsorption (HP:0002630)2.98779213
49Gastrointestinal inflammation (HP:0004386)2.96773591
50Inflammation of the large intestine (HP:0002037)2.96416800
51Hyporeflexia of lower limbs (HP:0002600)2.95613514
52Recurrent abscess formation (HP:0002722)2.95330500
53Hematochezia (HP:0002573)2.84954315
54Dicarboxylic aciduria (HP:0003215)2.84508733
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.84508733
56Muscle fiber splitting (HP:0003555)2.83181442
57Abnormality of skeletal muscle fiber size (HP:0012084)2.83132487
58Polycythemia (HP:0001901)2.82250471
59Urticaria (HP:0001025)2.72898673
60Toxemia of pregnancy (HP:0100603)2.72521881
61Cholelithiasis (HP:0001081)2.70348989
62Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.69051951
63Increased IgE level (HP:0003212)2.67795085
64Skin nodule (HP:0200036)2.66918752
65Metabolic acidosis (HP:0001942)2.66392389
66Glomerulonephritis (HP:0000099)2.64590121
67Epistaxis (HP:0000421)2.63206138
68Delayed CNS myelination (HP:0002188)2.62882155
69Myoglobinuria (HP:0002913)2.62156855
70Abnormal gallbladder morphology (HP:0012437)2.61564906
71Gastrointestinal infarctions (HP:0005244)2.60879473
72Abnormality of macrophages (HP:0004311)2.60602829
73Abnormality of purine metabolism (HP:0004352)2.57527578
74Cellulitis (HP:0100658)2.56454480
75Hepatocellular carcinoma (HP:0001402)2.55763374
76Recurrent gram-negative bacterial infections (HP:0005420)2.55106666
77Abnormality of nucleobase metabolism (HP:0010932)2.54091191
78Esophageal varix (HP:0002040)2.53897173
79Abnormal delayed hypersensitivity skin test (HP:0002963)2.52914028
80Oligomenorrhea (HP:0000876)2.51050753
81Recurrent bacterial skin infections (HP:0005406)2.50535165
82Meningitis (HP:0001287)2.50427385
83Granulocytopenia (HP:0001913)2.48392138
84Abnormality of pyrimidine metabolism (HP:0004353)2.47218417
85Retrobulbar optic neuritis (HP:0100654)2.46403265
86Optic neuritis (HP:0100653)2.46403265
87Stomatitis (HP:0010280)2.46387252
88Chronic obstructive pulmonary disease (HP:0006510)2.44102563
89Obstructive lung disease (HP:0006536)2.44102563
90Abnormality of serum amino acid levels (HP:0003112)2.43563927
91Acanthocytosis (HP:0001927)2.42559298
92Poikilocytosis (HP:0004447)2.41716735
93Vasculitis (HP:0002633)2.41686407
94Conjugated hyperbilirubinemia (HP:0002908)2.41673218
95Amyloidosis (HP:0011034)2.41355585
96Mitral stenosis (HP:0001718)2.39617456
97Hypochromic microcytic anemia (HP:0004840)2.34947504
98Vascular calcification (HP:0004934)2.32547100
99Gout (HP:0001997)2.31825199
100Paralysis (HP:0003470)2.30614671
101Centrally nucleated skeletal muscle fibers (HP:0003687)2.30099221
102Ileus (HP:0002595)2.27883612
103Acanthosis nigricans (HP:0000956)2.27657462
104Keratoconjunctivitis sicca (HP:0001097)2.25981642
105Steatorrhea (HP:0002570)2.24797472
106Gingival bleeding (HP:0000225)2.24637977
107Hypoglycemic seizures (HP:0002173)2.24433480
108Mediastinal lymphadenopathy (HP:0100721)2.21736881
109Lethargy (HP:0001254)2.21235696
110Gingivitis (HP:0000230)2.21219711
111Generalized aminoaciduria (HP:0002909)2.20920509
112Recurrent fungal infections (HP:0002841)2.19631567
113Nephritis (HP:0000123)2.18646515
114Spontaneous abortion (HP:0005268)2.17437761
115Late onset (HP:0003584)2.17265822
116Easy fatigability (HP:0003388)2.15874663
117Hemorrhage of the eye (HP:0011885)2.15849554
118Hypertriglyceridemia (HP:0002155)2.15311052
119Petechiae (HP:0000967)2.14498897
120Reticulocytosis (HP:0001923)2.14169897
121Leukocytosis (HP:0001974)2.14080094
122Growth hormone excess (HP:0000845)2.12371332
123Gastrointestinal dysmotility (HP:0002579)2.09465979
124Thoracic kyphosis (HP:0002942)2.09344754
125Sensorimotor neuropathy (HP:0007141)2.09203212
126Chest pain (HP:0100749)2.08618620
127Abnormality of iron homeostasis (HP:0011031)2.08579296
128Cardiovascular calcification (HP:0011915)2.08432526
129Abnormality of the nasal mucosa (HP:0000433)2.06544555
130Hyperinsulinemic hypoglycemia (HP:0000825)2.05422458
131Cerebral edema (HP:0002181)2.05128131
132Vomiting (HP:0002013)2.03344601
133Thrombophlebitis (HP:0004418)2.03204939
134Eosinophilia (HP:0001880)2.02438494
135Pustule (HP:0200039)2.02261836
136Abnormality of the gallbladder (HP:0005264)2.01390744
137Osteomyelitis (HP:0002754)2.01331260
138Purpura (HP:0000979)2.00634089
139Menorrhagia (HP:0000132)2.00170657
140Exercise-induced myalgia (HP:0003738)2.00051357
141Keratoconjunctivitis (HP:0001096)1.99293934
142Rhabdomyolysis (HP:0003201)1.97496081
143Abnormality of liposaccharide metabolism (HP:0010968)1.97322687
144Abnormality of glycosphingolipid metabolism (HP:0004343)1.97322687
145Abnormality of glycolipid metabolism (HP:0010969)1.97322687
146Abnormality of transition element cation homeostasis (HP:0011030)1.96275400
147Cholecystitis (HP:0001082)1.95723873
148Abnormal gallbladder physiology (HP:0012438)1.95723873
149EMG: myopathic abnormalities (HP:0003458)1.95195794
150Increased connective tissue (HP:0009025)1.95171098
151Autoimmune hemolytic anemia (HP:0001890)1.92297883
152Axonal loss (HP:0003447)1.92225443
153Neonatal onset (HP:0003623)1.92090277
154Encephalitis (HP:0002383)1.91860802
155Increased serum ferritin (HP:0003281)1.91059645
156Neck muscle weakness (HP:0000467)1.90986073
157Acute hepatic failure (HP:0006554)1.90380714
158Hydroxyprolinuria (HP:0003080)1.89463601
159Abnormality of proline metabolism (HP:0010907)1.89463601
160Hypercortisolism (HP:0001578)1.89404249
161Atrioventricular block (HP:0001678)1.89092484
162Aortic aneurysm (HP:0004942)1.88811568
163Pancreatitis (HP:0001733)1.88190716
164Spastic diplegia (HP:0001264)1.87473052
165Dysostosis multiplex (HP:0000943)1.87004810
166Nausea (HP:0002018)1.86934510
167Asymmetric septal hypertrophy (HP:0001670)1.86162842
168Pulmonary embolism (HP:0002204)1.85851304
169Spontaneous hematomas (HP:0007420)1.85603279
170Pulmonary infiltrates (HP:0002113)1.85228519
171Recurrent skin infections (HP:0001581)1.85127613
172Increased muscle lipid content (HP:0009058)1.84654514
173Stroke (HP:0001297)1.84620564
174Agammaglobulinemia (HP:0004432)1.83046328
175Autoimmune thrombocytopenia (HP:0001973)1.82785395
176Irritability (HP:0000737)1.79406807

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.38560660
2TRIB33.63095711
3ERN13.56156168
4SIK13.46697593
5FGFR43.26186822
6TIE12.77550835
7KDR2.64933394
8FES2.64376550
9PKN22.55229053
10TGFBR22.36937677
11TYK22.15854108
12PRPF4B2.04319071
13TTN1.97503916
14MARK31.89741113
15INSRR1.88723189
16RIPK41.86482465
17TAOK31.78222338
18TNK21.77585478
19MAP4K11.74303579
20MAP3K131.70042024
21TAOK11.68708837
22ARAF1.66265451
23CAMK1D1.61510567
24JAK11.61475240
25TBK11.59457095
26EPHB11.56234802
27PHKG21.50898106
28PHKG11.50898106
29TAOK21.50349269
30MAP2K31.49883682
31RIPK11.47422153
32LMTK21.40863123
33NEK91.38990744
34MAPK121.36569207
35MAPK111.34149362
36JAK21.33538629
37FLT31.30702161
38PTK61.30112543
39PRKAA21.28035191
40MAP3K71.25652748
41MAP3K61.21430497
42PINK11.19884766
43KIT1.19451253
44FGFR31.16595001
45MYLK1.15034979
46IKBKE1.11125670
47IRAK31.09882979
48CSK1.04979493
49MARK21.03740415
50KSR21.01452292
51OBSCN0.98875685
52CAMK1G0.98484004
53JAK30.96780934
54GRK50.96205674
55IRAK40.92499736
56MST1R0.91960742
57PIM10.91342221
58PIK3CG0.88240475
59MAP3K30.87019362
60ZAP700.86327045
61FGFR20.84816388
62CSF1R0.83177855
63TRPM70.82392999
64PDK40.80824793
65PDK30.80824793
66ICK0.79918710
67PDPK10.79868597
68GRK60.78770899
69TXK0.77327303
70PDK20.76724202
71MAP2K40.75790401
72MOS0.75753419
73ERBB40.75593177
74SGK30.75563208
75PRKD20.75526174
76EPHA30.75222730
77STK380.73252264
78PRKAA10.72599756
79MAP3K100.72469652
80HIPK20.72054053
81MAPK40.70971399
82LCK0.70630987
83RAF10.69915135
84MAP3K140.69893975
85ITK0.68058637
86ABL20.68033358
87LYN0.67855361
88DAPK20.67683882
89LATS10.67659510
90PIK3CA0.67587619
91FGR0.66436326
92MAPK70.64975986
93BLK0.64717226
94SGK2230.64389869
95SGK4940.64389869
96PDK10.64103495
97SIK30.63266145
98PRKD10.62713015
99CDK60.62676568
100GRK70.62085420
101LRRK20.61190634
102PRKCH0.60236342
103BMX0.60196286
104CAMK10.58310836
105CDC42BPA0.58200022
106CAMK40.56659781
107BTK0.56619808
108PRKACG0.55357753
109RPS6KC10.55158031
110RPS6KL10.55158031
111MUSK0.54518509
112RPS6KA20.54039528
113DMPK0.53888699
114MAP3K110.53508646
115HCK0.51755684
116EEF2K0.50688680
117PRKCQ0.50622491
118MAP2K20.49424723
119STK100.46815468
120STK40.46057958
121IGF1R0.45744616
122DYRK30.45434406
123GSK3A0.45237704
124SIK20.45020383
125TESK20.43958583
126RET0.43648577
127ERBB20.43494372
128RPS6KA60.42412633
129MAPK150.41563259
130PDGFRA0.41516312
131EIF2AK10.41380737
132TESK10.40896016
133SGK20.40891859
134CDK90.40717227
135TEC0.39204592
136MAP3K10.38270017
137MAPKAPK30.38200721
138SYK0.37684253
139CLK10.36767269
140EGFR0.34936136
141PTK2B0.34545826
142DYRK1B0.34165698
143GRK10.33549317
144MAP3K50.32503998
145PKN10.32239343
146IKBKB0.31498797

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.02626949
2Nitrogen metabolism_Homo sapiens_hsa009103.73474917
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.28723303
4Fatty acid degradation_Homo sapiens_hsa000713.00424649
5Arginine biosynthesis_Homo sapiens_hsa002202.90489634
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.86283243
7Complement and coagulation cascades_Homo sapiens_hsa046102.73289731
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.64941083
9Tryptophan metabolism_Homo sapiens_hsa003802.58418385
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.53267575
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.51486050
12Propanoate metabolism_Homo sapiens_hsa006402.46754856
13Fatty acid metabolism_Homo sapiens_hsa012122.29810013
14PPAR signaling pathway_Homo sapiens_hsa033202.25031286
15Caffeine metabolism_Homo sapiens_hsa002322.20179864
16Acute myeloid leukemia_Homo sapiens_hsa052212.12711825
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.09147754
18Peroxisome_Homo sapiens_hsa041462.05839800
19Staphylococcus aureus infection_Homo sapiens_hsa051502.05637055
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.99604663
21Butanoate metabolism_Homo sapiens_hsa006501.99296577
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.96160941
23Leishmaniasis_Homo sapiens_hsa051401.86771764
24B cell receptor signaling pathway_Homo sapiens_hsa046621.80153852
25beta-Alanine metabolism_Homo sapiens_hsa004101.72556383
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.70339782
27Allograft rejection_Homo sapiens_hsa053301.63705629
28Autoimmune thyroid disease_Homo sapiens_hsa053201.62285587
29Graft-versus-host disease_Homo sapiens_hsa053321.61292036
30Histidine metabolism_Homo sapiens_hsa003401.52818256
31Chemical carcinogenesis_Homo sapiens_hsa052041.52422576
32Pyruvate metabolism_Homo sapiens_hsa006201.51959175
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.51145929
34Bile secretion_Homo sapiens_hsa049761.50630624
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.47329345
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.45539445
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.44549210
38ABC transporters_Homo sapiens_hsa020101.43583288
39Primary immunodeficiency_Homo sapiens_hsa053401.42667980
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40134070
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39617085
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.37610652
43Carbon metabolism_Homo sapiens_hsa012001.36475835
44Retinol metabolism_Homo sapiens_hsa008301.36223210
45Tuberculosis_Homo sapiens_hsa051521.35939979
46Fatty acid elongation_Homo sapiens_hsa000621.32364400
47Starch and sucrose metabolism_Homo sapiens_hsa005001.32248294
48Hematopoietic cell lineage_Homo sapiens_hsa046401.31066907
49Phenylalanine metabolism_Homo sapiens_hsa003601.30618675
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28769392
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28085331
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27709091
53Selenocompound metabolism_Homo sapiens_hsa004501.25743385
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.25052823
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24477301
56Non-small cell lung cancer_Homo sapiens_hsa052231.20292020
57Tyrosine metabolism_Homo sapiens_hsa003501.17752095
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17370741
59Fatty acid biosynthesis_Homo sapiens_hsa000611.17005371
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16525754
61Pancreatic cancer_Homo sapiens_hsa052121.14877595
62T cell receptor signaling pathway_Homo sapiens_hsa046601.13494405
63Toxoplasmosis_Homo sapiens_hsa051451.12891078
64Chronic myeloid leukemia_Homo sapiens_hsa052201.11640423
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11129401
66Biosynthesis of amino acids_Homo sapiens_hsa012301.10714323
67Platelet activation_Homo sapiens_hsa046111.08708117
68Viral myocarditis_Homo sapiens_hsa054161.06906457
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06879423
70Intestinal immune network for IgA production_Homo sapiens_hsa046721.06507627
71Fat digestion and absorption_Homo sapiens_hsa049751.00995434
72Herpes simplex infection_Homo sapiens_hsa051681.00719595
73Sulfur metabolism_Homo sapiens_hsa009201.00497637
74Lysine degradation_Homo sapiens_hsa003101.00265811
75Measles_Homo sapiens_hsa051620.99877493
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.99666138
77Regulation of autophagy_Homo sapiens_hsa041400.98931309
78Type I diabetes mellitus_Homo sapiens_hsa049400.98055575
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.97169224
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.97158051
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95183424
82Chemokine signaling pathway_Homo sapiens_hsa040620.91603350
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89353659
84Sulfur relay system_Homo sapiens_hsa041220.87945798
85Influenza A_Homo sapiens_hsa051640.87524915
86Glycerolipid metabolism_Homo sapiens_hsa005610.87210258
87FoxO signaling pathway_Homo sapiens_hsa040680.86695362
88Folate biosynthesis_Homo sapiens_hsa007900.86367788
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.84189326
90Phagosome_Homo sapiens_hsa041450.83844817
91Arginine and proline metabolism_Homo sapiens_hsa003300.83185390
92VEGF signaling pathway_Homo sapiens_hsa043700.82328303
93Apoptosis_Homo sapiens_hsa042100.81716915
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.81611422
95TNF signaling pathway_Homo sapiens_hsa046680.80749330
96Asthma_Homo sapiens_hsa053100.80148256
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75420011
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74292828
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.72504746
100Vitamin digestion and absorption_Homo sapiens_hsa049770.72335671
101Steroid biosynthesis_Homo sapiens_hsa001000.71908713
102Antigen processing and presentation_Homo sapiens_hsa046120.69733527
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67634715
104Vitamin B6 metabolism_Homo sapiens_hsa007500.67483098
105Notch signaling pathway_Homo sapiens_hsa043300.67396298
106Hepatitis B_Homo sapiens_hsa051610.66831471
107Insulin resistance_Homo sapiens_hsa049310.66009885
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64993615
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63445881
110HIF-1 signaling pathway_Homo sapiens_hsa040660.62476381
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62430604
112Inositol phosphate metabolism_Homo sapiens_hsa005620.62139905
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62072875
114Renin secretion_Homo sapiens_hsa049240.59743258
115Prolactin signaling pathway_Homo sapiens_hsa049170.58189998
116Pentose phosphate pathway_Homo sapiens_hsa000300.57973418
117Endocytosis_Homo sapiens_hsa041440.57816498
118Rheumatoid arthritis_Homo sapiens_hsa053230.57429455
119Endometrial cancer_Homo sapiens_hsa052130.57309286
120mTOR signaling pathway_Homo sapiens_hsa041500.56877544
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55343496
122Renal cell carcinoma_Homo sapiens_hsa052110.54834149
123HTLV-I infection_Homo sapiens_hsa051660.54724656
124Choline metabolism in cancer_Homo sapiens_hsa052310.53078283
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.52464000
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52291804
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.51480087
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.51275628
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50053756
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.46999578
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44275404
132Glutathione metabolism_Homo sapiens_hsa004800.36826653
133Metabolic pathways_Homo sapiens_hsa011000.35688087
134Prion diseases_Homo sapiens_hsa050200.35411680
135Glucagon signaling pathway_Homo sapiens_hsa049220.27774157
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27472663
137AMPK signaling pathway_Homo sapiens_hsa041520.27164113
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.26458948
139Galactose metabolism_Homo sapiens_hsa000520.26019356
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.25258737
141Fructose and mannose metabolism_Homo sapiens_hsa000510.19810908
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19764271
143Insulin signaling pathway_Homo sapiens_hsa049100.17216868
144One carbon pool by folate_Homo sapiens_hsa006700.15135724
145Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.14648039
146Lysosome_Homo sapiens_hsa041420.11080561
147alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09632874
148Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.06367044
149Other glycan degradation_Homo sapiens_hsa005110.05718371
150Malaria_Homo sapiens_hsa051440.03878462
151Dilated cardiomyopathy_Homo sapiens_hsa054140.01057310
152RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1021655
153African trypanosomiasis_Homo sapiens_hsa05143-0.0999811
154Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.0999466
155Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0882607
156Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0823589
157Linoleic acid metabolism_Homo sapiens_hsa00591-0.0578114
158Amoebiasis_Homo sapiens_hsa05146-0.0487604
159Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0458603
160Pertussis_Homo sapiens_hsa05133-0.0395634
161Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0363749
162Osteoclast differentiation_Homo sapiens_hsa04380-0.0338925
163Hepatitis C_Homo sapiens_hsa05160-0.0215279
164Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0183797
165Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.0032946

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