GPR15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a G protein-coupled receptor that acts as a chemokine receptor for human immunodeficiency virus type 1 and 2. The encoded protein localizes to the cell membrane. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.83422640
2axon ensheathment in central nervous system (GO:0032291)8.83422640
3regulation of B cell receptor signaling pathway (GO:0050855)6.90387541
4CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)6.33566839
5fatty acid elongation (GO:0030497)5.90137292
6response to methylmercury (GO:0051597)5.62435229
7B cell receptor signaling pathway (GO:0050853)5.45348066
8myelination (GO:0042552)5.29310768
9axon ensheathment (GO:0008366)5.25423223
10ensheathment of neurons (GO:0007272)5.25423223
11cytidine deamination (GO:0009972)5.02263088
12cytidine metabolic process (GO:0046087)5.02263088
13cytidine catabolic process (GO:0006216)5.02263088
14T cell lineage commitment (GO:0002360)4.82379901
15cholesterol biosynthetic process (GO:0006695)4.72111740
16leukocyte aggregation (GO:0070486)4.61895440
17long-chain fatty acid biosynthetic process (GO:0042759)4.59374687
18antigen processing and presentation of endogenous antigen (GO:0019883)4.52489865
19negative regulation of neurotransmitter secretion (GO:0046929)4.50888324
20pyrimidine ribonucleoside catabolic process (GO:0046133)4.43575095
21B cell homeostasis (GO:0001782)4.43369413
22regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.35420590
23immunoglobulin mediated immune response (GO:0016064)4.35308583
24type I interferon signaling pathway (GO:0060337)4.34339329
25cellular response to type I interferon (GO:0071357)4.34339329
26response to type I interferon (GO:0034340)4.32798022
27interferon-gamma-mediated signaling pathway (GO:0060333)4.21210936
28regulation of collateral sprouting (GO:0048670)4.20642081
29positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.15684362
30modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.15586161
31positive regulation by organism of defense response of other organism involved in symbiotic interact4.15586161
32modulation by symbiont of host immune response (GO:0052553)4.15586161
33positive regulation by symbiont of host defense response (GO:0052509)4.15586161
34modulation by symbiont of host defense response (GO:0052031)4.15586161
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.15586161
36negative regulation of B cell proliferation (GO:0030889)4.09268862
37negative T cell selection (GO:0043383)4.08977834
38positive regulation of alpha-beta T cell proliferation (GO:0046641)4.08327968
39response to interleukin-15 (GO:0070672)4.06169204
40B cell mediated immunity (GO:0019724)4.06061606
41sterol biosynthetic process (GO:0016126)4.05911507
42positive regulation of humoral immune response (GO:0002922)4.04856735
43regulation of isotype switching to IgG isotypes (GO:0048302)4.02701176
44positive regulation of B cell differentiation (GO:0045579)4.01852415
45negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.00981737
46negative regulation of cell killing (GO:0031342)4.00981737
47response to redox state (GO:0051775)4.00207006
48negative thymic T cell selection (GO:0045060)3.99284398
49Rap protein signal transduction (GO:0032486)3.99002899
50positive regulation of T cell cytokine production (GO:0002726)3.97152983
51negative regulation of neurotransmitter transport (GO:0051589)3.96148647
52cellular response to interleukin-15 (GO:0071350)3.93942317
53activated T cell proliferation (GO:0050798)3.89797503
54eye photoreceptor cell differentiation (GO:0001754)3.89301578
55photoreceptor cell differentiation (GO:0046530)3.89301578
56nerve growth factor signaling pathway (GO:0038180)3.88101578
57positive regulation of gamma-delta T cell activation (GO:0046645)3.86312891
58amyloid precursor protein metabolic process (GO:0042982)3.84826209
59myeloid dendritic cell activation (GO:0001773)3.84275886
60B cell proliferation (GO:0042100)3.80888905
61response to lipoprotein particle (GO:0055094)3.80601631
62positive regulation of Rap GTPase activity (GO:0032854)3.79150386
63regulation of B cell differentiation (GO:0045577)3.78542732
64regulation of T cell tolerance induction (GO:0002664)3.75423516
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.75046771
66myeloid dendritic cell differentiation (GO:0043011)3.74808184
67NIK/NF-kappaB signaling (GO:0038061)3.73069064
68regulation of cytokine production involved in inflammatory response (GO:1900015)3.71863113
69Sertoli cell development (GO:0060009)3.65441959
70regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.65372399
71astrocyte development (GO:0014002)3.60923982
72cellular response to electrical stimulus (GO:0071257)3.60353764
73regulation of interleukin-2 biosynthetic process (GO:0045076)3.58251412
74creatine metabolic process (GO:0006600)3.57436332
75tolerance induction (GO:0002507)3.56533890
76peripheral nervous system axon ensheathment (GO:0032292)3.55384996
77myelination in peripheral nervous system (GO:0022011)3.55384996
78mast cell activation (GO:0045576)3.54422797
79positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.50022823
80positive regulation of interferon-alpha production (GO:0032727)3.40503595
81regulation of B cell proliferation (GO:0030888)3.37518339
82positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.37431076
83T-helper 1 type immune response (GO:0042088)3.35320380
84L-amino acid import (GO:0043092)3.33429604
85regulation of interferon-beta biosynthetic process (GO:0045357)3.32011011
86myelin maintenance (GO:0043217)3.31880186
87regulation of interleukin-13 production (GO:0032656)3.31849097
88cellular response to interferon-gamma (GO:0071346)3.30755783
89DNA deamination (GO:0045006)3.29953658
90regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.29585043
91mast cell degranulation (GO:0043303)3.27645134
92mast cell activation involved in immune response (GO:0002279)3.27645134
93peptidyl-tyrosine autophosphorylation (GO:0038083)3.25025811
94regulation of gamma-delta T cell differentiation (GO:0045586)3.24855630
95neuronal action potential propagation (GO:0019227)3.24584067
96long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.21605784
97regulation of Rap GTPase activity (GO:0032317)3.20627420
98interferon-gamma production (GO:0032609)3.20479458
99regulation of interferon-alpha production (GO:0032647)3.17864092
100nucleoside diphosphate catabolic process (GO:0009134)3.12479678
101oligodendrocyte differentiation (GO:0048709)3.11888078
102regulation of interferon-gamma biosynthetic process (GO:0045072)3.11660955
103long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.09607902
104* T cell migration (GO:0072678)3.09488695
105positive regulation of macrophage cytokine production (GO:0060907)3.08722049
106protein palmitoylation (GO:0018345)3.08538186
107detection of bacterium (GO:0016045)3.06870657
108lymphocyte costimulation (GO:0031294)3.05757186
109regulation of T cell cytokine production (GO:0002724)3.04981069
110positive regulation of interleukin-4 production (GO:0032753)3.03629504
111positive T cell selection (GO:0043368)3.03585131
112regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.02289636
113positive regulation of interleukin-2 production (GO:0032743)3.01482931
114mature B cell differentiation (GO:0002335)3.00529590
115positive regulation of cytokine biosynthetic process (GO:0042108)2.99664729
116lymphocyte homeostasis (GO:0002260)2.98612643
117positive regulation of cell fate commitment (GO:0010455)2.97497581
118thymic T cell selection (GO:0045061)2.96865654
119response to host immune response (GO:0052572)2.96676203
120response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.96676203
121T cell costimulation (GO:0031295)2.96443460
122regulation of T-helper 1 cell differentiation (GO:0045625)2.96186881
123negative regulation of viral genome replication (GO:0045071)2.95454020
124substantia nigra development (GO:0021762)2.93019371
125regulation of dendritic cell antigen processing and presentation (GO:0002604)2.92918188
126positive regulation of immunoglobulin mediated immune response (GO:0002891)2.92201744
127positive regulation of B cell mediated immunity (GO:0002714)2.92201744
128amyloid precursor protein catabolic process (GO:0042987)2.92052055
129isoprenoid biosynthetic process (GO:0008299)2.91158617
130negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.87753325
131positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.87165606
132T cell receptor signaling pathway (GO:0050852)2.87117644
133response to protozoan (GO:0001562)2.86130720
134regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.85600785
135defense response to protozoan (GO:0042832)2.84888762
136T cell selection (GO:0045058)2.82417769
137establishment of mitochondrion localization (GO:0051654)2.82233150
138adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.81675796
139regulation of gamma-delta T cell activation (GO:0046643)2.81239631
140positive regulation of interleukin-12 production (GO:0032735)2.80262831
141regulation of B cell activation (GO:0050864)2.80174570
142negative regulation of interleukin-10 production (GO:0032693)2.79893632
143response to interferon-gamma (GO:0034341)2.79611172
144positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.79500273
145regulation of alpha-beta T cell proliferation (GO:0046640)2.78663007
146positive regulation of interleukin-17 production (GO:0032740)2.78546424
147positive regulation of natural killer cell mediated immunity (GO:0002717)2.78111199
148positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.78111199
149detection of other organism (GO:0098543)2.77604759
150organ growth (GO:0035265)2.76104332
151positive regulation of B cell proliferation (GO:0030890)2.75530678
152positive regulation of tolerance induction (GO:0002645)2.75439298
153antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.74380087
154antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.74380087
155regulation of antigen processing and presentation (GO:0002577)2.72956728
156semaphorin-plexin signaling pathway (GO:0071526)2.72536586
157adhesion of symbiont to host cell (GO:0044650)2.72164024
158virion attachment to host cell (GO:0019062)2.72164024
159regulation of chronic inflammatory response (GO:0002676)2.72071548
160negative regulation of execution phase of apoptosis (GO:1900118)2.71401926
161negative regulation of axonogenesis (GO:0050771)2.71344258
162positive regulation of B cell activation (GO:0050871)2.69576722
163fatty-acyl-CoA metabolic process (GO:0035337)2.69330948
164regulation of lipoprotein metabolic process (GO:0050746)2.68670630
165response to host (GO:0075136)2.68622085
166response to host defenses (GO:0052200)2.68622085
167response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.68622085
168regulation of alpha-beta T cell activation (GO:0046634)2.68502219
169regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.67009853
170regulation of natural killer cell mediated immunity (GO:0002715)2.67009853
171membrane protein ectodomain proteolysis (GO:0006509)2.63434937
172fatty-acyl-CoA biosynthetic process (GO:0046949)2.63059865
173positive thymic T cell selection (GO:0045059)2.62385237
174phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.60536614
175regulation of ARF GTPase activity (GO:0032312)2.59866280
176antigen receptor-mediated signaling pathway (GO:0050851)2.58692607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.17632554
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.05563184
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.12820985
4MYC_22102868_ChIP-Seq_BL_Human3.90086305
5VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.47574820
6E2F7_22180533_ChIP-Seq_HELA_Human3.44437562
7RUNX_20019798_ChIP-Seq_JUKART_Human3.38439443
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.04091812
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.99995094
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.99469999
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.97494571
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.82892453
13AR_21572438_ChIP-Seq_LNCaP_Human2.67336688
14GATA1_22025678_ChIP-Seq_K562_Human2.66296277
15CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.59163429
16* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.58029991
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.57246397
18CIITA_25753668_ChIP-Seq_RAJI_Human2.43453875
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.32596630
20SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.24213851
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.19890991
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16179271
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.13912379
24DROSHA_22980978_ChIP-Seq_HELA_Human2.08720489
25TAF15_26573619_Chip-Seq_HEK293_Human2.07814027
26MYB_26560356_Chip-Seq_TH2_Human2.00034652
27VDR_24763502_ChIP-Seq_THP-1_Human1.93539373
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92762293
29SCL_19346495_ChIP-Seq_HPC-7_Human1.92416785
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.83959491
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.82367775
32VDR_23849224_ChIP-Seq_CD4+_Human1.80119173
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.79235170
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.74104642
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71398937
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70916142
37VDR_22108803_ChIP-Seq_LS180_Human1.70658311
38MAF_26560356_Chip-Seq_TH1_Human1.70568463
39VDR_21846776_ChIP-Seq_THP-1_Human1.70532321
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.66294054
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62030851
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60047445
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59208474
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59094015
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53768946
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.51824548
47GATA3_27048872_Chip-Seq_THYMUS_Human1.51540317
48TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51345032
49VDR_24787735_ChIP-Seq_THP-1_Human1.51014358
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50857778
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.50377256
52MYB_26560356_Chip-Seq_TH1_Human1.49886485
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49407266
54SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48333824
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46045131
56FOXP3_21729870_ChIP-Seq_TREG_Human1.43923187
57KDM2B_26808549_Chip-Seq_DND41_Human1.43494674
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41935712
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41146467
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.40764157
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40059147
62MAF_26560356_Chip-Seq_TH2_Human1.39658250
63IRF1_19129219_ChIP-ChIP_H3396_Human1.39598226
64* GATA3_26560356_Chip-Seq_TH2_Human1.38266447
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31802480
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30877468
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29504819
68CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27967338
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27717354
70SPI1_23127762_ChIP-Seq_K562_Human1.26648588
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26127847
72MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25162404
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21998628
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.21197485
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20892840
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20259726
77MYC_19079543_ChIP-ChIP_MESCs_Mouse1.19161726
78PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.19150007
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17887669
80EST1_17652178_ChIP-ChIP_JURKAT_Human1.17677790
81TAL1_26923725_Chip-Seq_HPCs_Mouse1.17649526
82NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17458175
83LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16477774
84TCF7_22412390_ChIP-Seq_EML_Mouse1.16370590
85NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16279767
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14928281
87STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13254564
88RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12956643
89NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12788386
90UTX_26944678_Chip-Seq_JUKART_Human1.11791448
91DCP1A_22483619_ChIP-Seq_HELA_Human1.10567230
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.09992502
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09854631
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09135211
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06058173
96IRF8_22096565_ChIP-ChIP_GC-B_Human1.05186724
97E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05153522
98HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04970175
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.04641071
100TP53_16413492_ChIP-PET_HCT116_Human1.04200881
101WT1_19549856_ChIP-ChIP_CCG9911_Human1.03676469
102KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03389622
103MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02640719
104CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01984541
105GATA1_19941826_ChIP-Seq_K562_Human1.01723350
106CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.01138395
107KDM2B_26808549_Chip-Seq_JURKAT_Human1.00126950
108SPI1_23547873_ChIP-Seq_NB4_Human0.99669305
109PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98679851
110KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98065813
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97983123
112CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97409443
113GF1_26923725_Chip-Seq_HPCs_Mouse0.97154070
114EZH2_27294783_Chip-Seq_ESCs_Mouse0.94233346
115GATA1_19941827_ChIP-Seq_MEL_Mouse0.94021455
116ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93280157
117SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92313829
118ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91660601
119EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91379925
120SMRT_27268052_Chip-Seq_Bcells_Human0.90619063
121RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90549144
122SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90051402
123NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89908091
124PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89832805
125SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89485240
126ELK1_19687146_ChIP-ChIP_HELA_Human0.88509924
127SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88081770
128ETS1_20019798_ChIP-Seq_JURKAT_Human0.88018543
129PIAS1_25552417_ChIP-Seq_VCAP_Human0.87934199
130GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87603819
131GABP_17652178_ChIP-ChIP_JURKAT_Human0.87384929
132GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87167852
133JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.86817875
134POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.86529362
135E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86432742
136RUNX1_22412390_ChIP-Seq_EML_Mouse0.86263389
137SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.85173733
138THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84893014
139TCF4_23295773_ChIP-Seq_U87_Human0.84872735
140GATA2_19941826_ChIP-Seq_K562_Human0.84347907
141RARB_27405468_Chip-Seq_BRAIN_Mouse0.84081042
142CMYC_18555785_Chip-Seq_ESCs_Mouse0.84016186
143GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83489631
144ER_23166858_ChIP-Seq_MCF-7_Human0.83266569
145MTF2_20144788_ChIP-Seq_MESCs_Mouse0.83147346
146KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83006285
147MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.82247107
148CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82086845
149SMAD_19615063_ChIP-ChIP_OVARY_Human0.81794909
150EZH2_22144423_ChIP-Seq_EOC_Human0.81690748
151TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81438172
152FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.81054671
153PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80837721
154VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.78124366
155EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77966590
156LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76849612
157PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76608254
158GATA1_26923725_Chip-Seq_HPCs_Mouse0.75195105
159CBP_21632823_ChIP-Seq_H3396_Human0.74381953

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.44933461
2MP0002166_altered_tumor_susceptibility3.77179300
3MP0004381_abnormal_hair_follicle3.24080503
4MP0003300_gastrointestinal_ulcer2.93957845
5MP0003690_abnormal_glial_cell2.86525866
6MP0002006_tumorigenesis2.86247603
7MP0003763_abnormal_thymus_physiology2.73014097
8MP0008057_abnormal_DNA_replication2.70954815
9MP0003329_amyloid_beta_deposits2.58942706
10MP0005671_abnormal_response_to2.57340431
11MP0004742_abnormal_vestibular_system2.45087553
12MP0005387_immune_system_phenotype2.24893974
13MP0001790_abnormal_immune_system2.24893974
14MP0003045_fibrosis2.24824263
15MP0005410_abnormal_fertilization2.23168476
16MP0005645_abnormal_hypothalamus_physiol2.21772550
17MP0002822_catalepsy2.18911191
18MP0005000_abnormal_immune_tolerance2.16156815
19MP0002138_abnormal_hepatobiliary_system2.13965293
20MP0010094_abnormal_chromosome_stability2.12451983
21MP0003656_abnormal_erythrocyte_physiolo2.09120628
22MP0003950_abnormal_plasma_membrane2.09022555
23MP0001800_abnormal_humoral_immune2.06628910
24MP0002933_joint_inflammation2.02665136
25MP0002163_abnormal_gland_morphology2.01977611
26MP0001905_abnormal_dopamine_level1.96397923
27MP0000685_abnormal_immune_system1.94030478
28MP0001348_abnormal_lacrimal_gland1.90531743
29MP0002723_abnormal_immune_serum1.84717429
30MP0003136_yellow_coat_color1.83943896
31MP0001835_abnormal_antigen_presentation1.82181602
32MP0000604_amyloidosis1.81653059
33MP0002420_abnormal_adaptive_immunity1.79890450
34MP0003866_abnormal_defecation1.79251425
35MP0002148_abnormal_hypersensitivity_rea1.78818181
36MP0003880_abnormal_central_pattern1.77531986
37MP0001986_abnormal_taste_sensitivity1.76496162
38MP0001819_abnormal_immune_cell1.74877914
39MP0003303_peritoneal_inflammation1.70875691
40MP0003172_abnormal_lysosome_physiology1.70862414
41MP0005025_abnormal_response_to1.68881483
42MP0003632_abnormal_nervous_system1.68372486
43MP0002452_abnormal_antigen_presenting1.65952638
44MP0003634_abnormal_glial_cell1.65635178
45MP0003436_decreased_susceptibility_to1.65469935
46MP0009333_abnormal_splenocyte_physiolog1.63487573
47MP0001485_abnormal_pinna_reflex1.59854714
48MP0003693_abnormal_embryo_hatching1.59850432
49MP0009785_altered_susceptibility_to1.59744019
50MP0002272_abnormal_nervous_system1.59322854
51MP0006082_CNS_inflammation1.58134183
52MP0002419_abnormal_innate_immunity1.57062576
53MP0000465_gastrointestinal_hemorrhage1.56052449
54MP0003724_increased_susceptibility_to1.52908717
55MP0003111_abnormal_nucleus_morphology1.46725884
56MP0002398_abnormal_bone_marrow1.45120888
57MP0000716_abnormal_immune_system1.44629994
58MP0001486_abnormal_startle_reflex1.43293110
59MP0005310_abnormal_salivary_gland1.41871458
60MP0010155_abnormal_intestine_physiology1.40567906
61MP0003077_abnormal_cell_cycle1.39882604
62MP0004885_abnormal_endolymph1.38848765
63MP0001529_abnormal_vocalization1.37387684
64MP0004270_analgesia1.33721687
65MP0004134_abnormal_chest_morphology1.33594790
66MP0008260_abnormal_autophagy1.27696278
67MP0002229_neurodegeneration1.27225115
68MP0001851_eye_inflammation1.25032190
69MP0002019_abnormal_tumor_incidence1.23466241
70MP0003631_nervous_system_phenotype1.22806919
71MP0005058_abnormal_lysosome_morphology1.16772374
72MP0009745_abnormal_behavioral_response1.16470021
73MP0005623_abnormal_meninges_morphology1.15622711
74MP0004036_abnormal_muscle_relaxation1.14454255
75MP0000689_abnormal_spleen_morphology1.14429107
76MP0002405_respiratory_system_inflammati1.14302315
77MP0005464_abnormal_platelet_physiology1.13453668
78MP0005451_abnormal_body_composition1.13431874
79MP0002009_preneoplasia1.10525715
80MP0003183_abnormal_peptide_metabolism1.08836191
81MP0005075_abnormal_melanosome_morpholog1.08740575
82MP0005379_endocrine/exocrine_gland_phen1.08287226
83MP0000372_irregular_coat_pigmentation1.07028314
84MP0002064_seizures1.05658891
85MP0002396_abnormal_hematopoietic_system1.05424255
86MP0000778_abnormal_nervous_system1.05214547
87MP0002722_abnormal_immune_system1.05036367
88MP0002429_abnormal_blood_cell1.03587662
89MP0003633_abnormal_nervous_system1.03394445
90MP0003195_calcinosis1.02328443
91MP0002234_abnormal_pharynx_morphology1.01517459
92MP0008874_decreased_physiological_sensi1.00073245
93MP0004185_abnormal_adipocyte_glucose0.99229633
94MP0004859_abnormal_synaptic_plasticity0.98029715
95MP0004145_abnormal_muscle_electrophysio0.94013431
96MP0000703_abnormal_thymus_morphology0.93885874
97MP0005174_abnormal_tail_pigmentation0.93160146
98MP0004808_abnormal_hematopoietic_stem0.91285000
99MP0010678_abnormal_skin_adnexa0.89783586
100MP0004957_abnormal_blastocyst_morpholog0.88902212
101MP0008469_abnormal_protein_level0.86890478
102MP0001873_stomach_inflammation0.86634859
103MP0003075_altered_response_to0.85757154
104MP0001845_abnormal_inflammatory_respons0.85530503
105MP0003453_abnormal_keratinocyte_physiol0.85237824
106MP0000383_abnormal_hair_follicle0.85127581
107MP0000350_abnormal_cell_proliferation0.83163256
108MP0003635_abnormal_synaptic_transmissio0.82723802
109MP0000490_abnormal_crypts_of0.82132902
110MP0002928_abnormal_bile_duct0.82101986
111MP0003959_abnormal_lean_body0.82026782
112MP0004924_abnormal_behavior0.81542175
113MP0005386_behavior/neurological_phenoty0.81542175
114MP0010307_abnormal_tumor_latency0.81286910
115MP0003252_abnormal_bile_duct0.80846992
116MP0004142_abnormal_muscle_tone0.80340139
117MP0001533_abnormal_skeleton_physiology0.79560966
118MP0006035_abnormal_mitochondrial_morpho0.78730378
119MP0004947_skin_inflammation0.77640455
120MP0000747_muscle_weakness0.77271117
121MP0002693_abnormal_pancreas_physiology0.77199113
122MP0010234_abnormal_vibrissa_follicle0.77008100
123MP0000313_abnormal_cell_death0.76829045
124MP0008058_abnormal_DNA_repair0.76243794
125MP0001853_heart_inflammation0.75947795
126MP0005220_abnormal_exocrine_pancreas0.75397709
127MP0002998_abnormal_bone_remodeling0.75095250
128MP0001299_abnormal_eye_distance/0.73677140
129MP0001346_abnormal_lacrimal_gland0.73315374
130MP0003091_abnormal_cell_migration0.73015686
131MP0002572_abnormal_emotion/affect_behav0.72730356
132MP0005584_abnormal_enzyme/coenzyme_acti0.72471680
133MP0000858_altered_metastatic_potential0.72447137
134MP0000427_abnormal_hair_cycle0.69620659
135MP0003448_altered_tumor_morphology0.68908664
136MP0008569_lethality_at_weaning0.68314471
137MP0009763_increased_sensitivity_to0.63344920
138MP0008872_abnormal_physiological_respon0.61479651
139MP0003221_abnormal_cardiomyocyte_apopto0.60038530
140MP0003868_abnormal_feces_composition0.59475378
141MP0008007_abnormal_cellular_replicative0.58871817
142MP0002139_abnormal_hepatobiliary_system0.57560092
143MP0003786_premature_aging0.56752929
144MP0002136_abnormal_kidney_physiology0.55953668
145MP0002168_other_aberrant_phenotype0.54369635
146MP0000371_diluted_coat_color0.53604382
147MP0008961_abnormal_basal_metabolism0.52760791
148MP0000609_abnormal_liver_physiology0.52754149
149MP0005621_abnormal_cell_physiology0.51433122
150MP0001727_abnormal_embryo_implantation0.49182948
151MP0005166_decreased_susceptibility_to0.47324278
152MP0000015_abnormal_ear_pigmentation0.46148594
153MP0002083_premature_death0.41058120
154MP0000249_abnormal_blood_vessel0.40307987

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.37348692
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.09570577
3Degeneration of the lateral corticospinal tracts (HP:0002314)6.09570577
4Neurofibrillary tangles (HP:0002185)4.80591314
5Lymphopenia (HP:0001888)4.68075304
6Onion bulb formation (HP:0003383)4.64117111
7IgG deficiency (HP:0004315)4.58654872
8Abnormality of cells of the lymphoid lineage (HP:0012140)4.58450660
9Colitis (HP:0002583)4.44638887
10Abnormality of the corticospinal tract (HP:0002492)4.26134932
11Mediastinal lymphadenopathy (HP:0100721)4.12352818
12Sensory axonal neuropathy (HP:0003390)3.94304483
13Cerebral inclusion bodies (HP:0100314)3.83597468
14Peripheral hypomyelination (HP:0007182)3.78828585
15Chronic otitis media (HP:0000389)3.77230915
16Emphysema (HP:0002097)3.74864138
17Spastic gait (HP:0002064)3.72723324
18Autoimmune hemolytic anemia (HP:0001890)3.72513015
19Cerebral hypomyelination (HP:0006808)3.68498688
20Cellulitis (HP:0100658)3.65308736
21Absent hand (HP:0004050)3.53404616
22T lymphocytopenia (HP:0005403)3.40260353
23Parakeratosis (HP:0001036)3.39952149
24Recurrent lower respiratory tract infections (HP:0002783)3.31651425
25B lymphocytopenia (HP:0010976)3.27779647
26Abnormality of T cell number (HP:0011839)3.22650890
27Lymphoma (HP:0002665)3.21010805
28Verrucae (HP:0200043)3.19405490
29Papilloma (HP:0012740)3.19405490
30Recurrent pneumonia (HP:0006532)3.13206142
31Stomatitis (HP:0010280)3.12439023
32Increased IgM level (HP:0003496)3.08516461
33Persistence of primary teeth (HP:0006335)3.03206143
34Osteomyelitis (HP:0002754)3.00051021
35Distal lower limb amyotrophy (HP:0008944)2.99677813
36Abnormality of B cell number (HP:0010975)2.99509429
37Recurrent bronchitis (HP:0002837)2.92574189
38Recurrent bacterial skin infections (HP:0005406)2.92184209
39Muscle hypertrophy of the lower extremities (HP:0008968)2.89784801
40Bronchitis (HP:0012387)2.89645804
41Cerebral hemorrhage (HP:0001342)2.88071452
42Relative macrocephaly (HP:0004482)2.87882369
43Viral hepatitis (HP:0006562)2.86687871
44Basal cell carcinoma (HP:0002671)2.86635384
45Abnormality of the prostate (HP:0008775)2.81980370
46Termporal pattern (HP:0011008)2.81742803
47Insidious onset (HP:0003587)2.81742803
48Hepatosplenomegaly (HP:0001433)2.81609513
49Axonal loss (HP:0003447)2.80621502
50Supranuclear gaze palsy (HP:0000605)2.77587874
51IgM deficiency (HP:0002850)2.76281176
52Recurrent sinusitis (HP:0011108)2.75958087
53Premature loss of primary teeth (HP:0006323)2.75879901
54Squamous cell carcinoma (HP:0002860)2.75050213
55Chin dimple (HP:0010751)2.73659506
56Panhypogammaglobulinemia (HP:0003139)2.72917727
57Recurrent abscess formation (HP:0002722)2.72318593
58Recurrent skin infections (HP:0001581)2.65734764
59Scanning speech (HP:0002168)2.62459957
60Recurrent cutaneous fungal infections (HP:0011370)2.62111761
61Chronic mucocutaneous candidiasis (HP:0002728)2.62111761
62Urticaria (HP:0001025)2.59255185
63Elevated erythrocyte sedimentation rate (HP:0003565)2.56074932
64Inflammation of the large intestine (HP:0002037)2.55054436
65Leukopenia (HP:0001882)2.54607883
66Slow saccadic eye movements (HP:0000514)2.54514540
67Abnormal delayed hypersensitivity skin test (HP:0002963)2.53547553
68Stridor (HP:0010307)2.51817058
69Intention tremor (HP:0002080)2.51035890
70Recurrent viral infections (HP:0004429)2.48426492
71Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.46456089
72IgA deficiency (HP:0002720)2.46256116
73Lower limb amyotrophy (HP:0007210)2.45043000
74Abnormality of T cells (HP:0002843)2.44880940
75Gastrointestinal infarctions (HP:0005244)2.42489382
76Recurrent fungal infections (HP:0002841)2.40336190
77Poikiloderma (HP:0001029)2.37860311
78Septate vagina (HP:0001153)2.37596615
79Ankle clonus (HP:0011448)2.36988641
80Chronic obstructive pulmonary disease (HP:0006510)2.35969664
81Obstructive lung disease (HP:0006536)2.35969664
82Eczematoid dermatitis (HP:0000976)2.35959459
83Loss of speech (HP:0002371)2.35502718
84Skin rash (HP:0000988)2.34567734
85Optic neuritis (HP:0100653)2.33092539
86Retrobulbar optic neuritis (HP:0100654)2.33092539
87Gastrointestinal stroma tumor (HP:0100723)2.32841410
88Recurrent otitis media (HP:0000403)2.32658028
89Xerostomia (HP:0000217)2.32271424
90Seborrheic dermatitis (HP:0001051)2.31927149
91Arthralgia (HP:0002829)2.29752706
92Gastrointestinal inflammation (HP:0004386)2.29528575
93Increased circulating renin level (HP:0000848)2.29522254
94Acute hepatic failure (HP:0006554)2.28428041
95Poor speech (HP:0002465)2.27688686
96Premature skin wrinkling (HP:0100678)2.26265320
97Pulmonary embolism (HP:0002204)2.25766731
98Myositis (HP:0100614)2.24674500
99Abnormality of T cell physiology (HP:0011840)2.23744933
100Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22708957
101Chronic sinusitis (HP:0011109)2.20957927
102Hepatitis (HP:0012115)2.19599144
103Vasculitis (HP:0002633)2.17988868
104Chest pain (HP:0100749)2.16146372
105Partial agenesis of the corpus callosum (HP:0001338)2.15722328
106Sepsis (HP:0100806)2.13833885
107Meningitis (HP:0001287)2.12328366
108Fatigue (HP:0012378)2.11050844
109Eosinophilia (HP:0001880)2.10936678
110Bronchiectasis (HP:0002110)2.10745256
111Hemoptysis (HP:0002105)2.10340065
112Akinesia (HP:0002304)2.10094505
113Dysmetria (HP:0001310)2.08857172
114Centrally nucleated skeletal muscle fibers (HP:0003687)2.08168351
115Hammertoe (HP:0001765)2.07499244
116Hypertensive crisis (HP:0100735)2.07299735
117Increased IgE level (HP:0003212)2.07172124
118Split hand (HP:0001171)2.06968815
119Sparse scalp hair (HP:0002209)2.05982607
120Abnormality of eosinophils (HP:0001879)2.05829869
121Entropion (HP:0000621)2.05523144
122Amaurosis fugax (HP:0100576)2.03111433
123Restrictive lung disease (HP:0002091)2.02919349
124Granulocytopenia (HP:0001913)2.02425959
125Anomalous pulmonary venous return (HP:0010772)2.01867791
126Spastic paraparesis (HP:0002313)2.00844827
127J-shaped sella turcica (HP:0002680)1.99313115
128Pulmonary infiltrates (HP:0002113)1.99064351
129Thoracolumbar scoliosis (HP:0002944)1.98267114
130Neutropenia (HP:0001875)1.98081382
131Abnormality of male internal genitalia (HP:0000022)1.95590967
132Skin ulcer (HP:0200042)1.93850920
133Abnormality of the lumbar spine (HP:0100712)1.93310652
134Joint swelling (HP:0001386)1.92366093
135Severe combined immunodeficiency (HP:0004430)1.91283767
136Abnormality of glycolysis (HP:0004366)1.91104727
137Increased serum pyruvate (HP:0003542)1.91104727
138Dry hair (HP:0011359)1.91039841
139Limb dystonia (HP:0002451)1.88643508
140Insomnia (HP:0100785)1.87238933
141Submucous cleft hard palate (HP:0000176)1.85908060
142Pulmonary fibrosis (HP:0002206)1.85517001
143Abnormality of macrophages (HP:0004311)1.85198742
144Anteriorly placed anus (HP:0001545)1.84573799
145Abnormality of the pleura (HP:0002103)1.83931807
146Orchitis (HP:0100796)1.83208567
147Hyperlipoproteinemia (HP:0010980)1.83052912
148Leukocytosis (HP:0001974)1.82674521
149Lower limb muscle weakness (HP:0007340)1.82346155
150Chronic diarrhea (HP:0002028)1.82260538
151Abnormality of the fingertips (HP:0001211)1.81762042
152Arterial thrombosis (HP:0004420)1.81672228
153Hypergammaglobulinemia (HP:0010702)1.81430659
154Encephalitis (HP:0002383)1.80808301
155Combined immunodeficiency (HP:0005387)1.80454349
156Autoimmune thrombocytopenia (HP:0001973)1.79896746
157Generalized hypotonia (HP:0001290)1.79313859
158Spondylolisthesis (HP:0003302)1.78287884
159Gangrene (HP:0100758)1.76096068
160Aplasia/Hypoplasia of the thymus (HP:0010515)1.74174000
161Acrocyanosis (HP:0001063)1.73778803
162Prostate neoplasm (HP:0100787)1.72120129
163Ureteral obstruction (HP:0006000)1.71747737

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.93616421
2EPHB14.71678361
3TNIK4.20920521
4RIPK44.20359711
5EIF2AK34.08273337
6TXK3.68519371
7CLK13.49769898
8MAP4K13.41882251
9CASK3.10146720
10NEK93.05700550
11SMG12.86370087
12OXSR12.42706619
13MAPKAPK52.24031655
14CCNB12.14869649
15PKN12.11578556
16IRAK11.90579961
17STK241.90296422
18BMPR21.89374720
19PASK1.89100849
20IRAK41.80633653
21VRK11.79591349
22MST41.76510045
23ZAK1.73229951
24STK101.70895255
25ITK1.69038505
26TBK11.66414523
27EEF2K1.66314293
28FGFR41.66269977
29MAPK131.63856608
30TAF11.61869901
31PRKCQ1.61042975
32JAK31.53057184
33UHMK11.46796103
34TAOK31.38446075
35TYRO31.35287429
36EPHA31.30901124
37ROCK21.30897923
38LCK1.30580894
39MAP3K101.27986529
40WNK41.25904700
41MAPK111.25555057
42FES1.25366734
43BTK1.24407808
44JAK11.21259194
45FGR1.19246437
46FGFR31.18161945
47NLK1.18005089
48BUB11.16014956
49ZAP701.10226073
50PIM11.08427881
51IKBKE1.04027436
52CDC71.02715282
53SGK4941.02626362
54SGK2231.02626362
55MET1.01263621
56CSK1.00101221
57DYRK20.99959679
58RPS6KA50.97758681
59TESK20.94148874
60NME20.91814364
61PRKCH0.91594813
62MAP3K130.89273702
63EIF2AK10.86959408
64STK38L0.86872388
65IRAK20.86681010
66FGFR20.86046404
67DAPK30.85372035
68ALK0.82611957
69GRK60.80335659
70CHUK0.79997089
71MAP3K70.79452534
72VRK20.79053313
73NTRK10.77023740
74FYN0.76743636
75EIF2AK20.76213351
76LRRK20.76209102
77IRAK30.75424199
78CSNK1G30.74673938
79MAP3K140.73875503
80PRPF4B0.71066993
81SIK30.69829793
82SYK0.69662496
83HIPK20.69299824
84PRKCI0.68736287
85MATK0.68387045
86HCK0.67581513
87WNK10.66105462
88PAK30.65215555
89NEK60.63529471
90CDK40.62997844
91MAP3K80.62874120
92DMPK0.62768077
93PAK60.62635951
94PIK3CG0.58930765
95CSNK1A1L0.58169367
96TYK20.57841889
97CSF1R0.57812570
98JAK20.57523440
99SIK10.56703619
100TRPM70.55851835
101SIK20.55077980
102BCR0.54421879
103TEC0.53908390
104PDGFRB0.53799079
105CSNK1G20.53739779
106CSNK1G10.53678983
107NEK10.53013470
108TLK10.52971402
109CDK120.52584676
110MAPK70.52397445
111CAMKK20.51873073
112BRD40.51503490
113RPS6KB20.51291039
114PAK20.49583795
115LYN0.49338932
116BLK0.49204263
117BMPR1B0.48013685
118CAMK2B0.46213648
119IKBKB0.46092157
120PDK10.46030427
121GSK3A0.45797720
122INSR0.44679859
123PRKD10.44016403
124CDK50.42769315
125MAP3K50.42236324
126MAPK120.41473019
127ATR0.41023904
128NME10.40897688
129MAP3K60.40644676
130MAPK40.40224340
131MELK0.39793613
132MARK30.39436912
133CSNK1D0.39335497
134MAPKAPK20.39261620
135CAMKK10.37705111
136PRKCD0.36738852
137BMX0.34952006
138BCKDK0.34353325
139CDC42BPA0.34236178
140STK160.33761549
141STK30.33232745
142CHEK10.32829468
143NUAK10.32696620
144ERN10.32651672
145AURKB0.31746046
146DAPK10.31251494
147RET0.30789325
148MAP3K90.29988622
149TTN0.29031169
150AURKA0.28828367
151MUSK0.28637460
152KIT0.28005331
153CDK90.27476640
154PRKCE0.27423186
155STK40.27127243
156CHEK20.27083123
157CDK190.26743683
158PIM20.25800728
159TAOK20.25692841

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.52408860
2Steroid biosynthesis_Homo sapiens_hsa001005.00544362
3Primary immunodeficiency_Homo sapiens_hsa053403.60880209
4Type I diabetes mellitus_Homo sapiens_hsa049403.46931971
5Systemic lupus erythematosus_Homo sapiens_hsa053223.32647370
6Fatty acid elongation_Homo sapiens_hsa000623.02788559
7Ether lipid metabolism_Homo sapiens_hsa005652.93305671
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.71112865
9T cell receptor signaling pathway_Homo sapiens_hsa046602.70474821
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.39716986
11Cell adhesion molecules (CAMs)_Homo sapiens_hsa045142.11658567
12Autoimmune thyroid disease_Homo sapiens_hsa053202.10797743
13Allograft rejection_Homo sapiens_hsa053301.99321186
14Herpes simplex infection_Homo sapiens_hsa051681.94311947
15B cell receptor signaling pathway_Homo sapiens_hsa046621.87768329
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.87275226
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.78693639
18Influenza A_Homo sapiens_hsa051641.76757676
19Epstein-Barr virus infection_Homo sapiens_hsa051691.59111178
20Viral carcinogenesis_Homo sapiens_hsa052031.53138958
21Alcoholism_Homo sapiens_hsa050341.49717434
22Asthma_Homo sapiens_hsa053101.46244270
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44997101
24Renal cell carcinoma_Homo sapiens_hsa052111.42077808
25ABC transporters_Homo sapiens_hsa020101.35942268
26Axon guidance_Homo sapiens_hsa043601.33706033
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.31793848
28Linoleic acid metabolism_Homo sapiens_hsa005911.30866245
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30607026
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28980688
31Histidine metabolism_Homo sapiens_hsa003401.28939959
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.24999142
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23866490
34Apoptosis_Homo sapiens_hsa042101.22753010
35Measles_Homo sapiens_hsa051621.20196524
36Rheumatoid arthritis_Homo sapiens_hsa053231.17925502
37Osteoclast differentiation_Homo sapiens_hsa043801.16559093
38Chemokine signaling pathway_Homo sapiens_hsa040621.15361632
39Platelet activation_Homo sapiens_hsa046111.14395541
40Hematopoietic cell lineage_Homo sapiens_hsa046401.08926909
41Hepatitis B_Homo sapiens_hsa051611.07307098
42DNA replication_Homo sapiens_hsa030301.02939670
43Tuberculosis_Homo sapiens_hsa051521.02137396
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00774929
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00514484
46Long-term depression_Homo sapiens_hsa047300.99670753
47p53 signaling pathway_Homo sapiens_hsa041150.99049292
48Jak-STAT signaling pathway_Homo sapiens_hsa046300.98676467
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.96522663
50Sphingolipid signaling pathway_Homo sapiens_hsa040710.94824201
51HTLV-I infection_Homo sapiens_hsa051660.92346564
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87511645
53Leishmaniasis_Homo sapiens_hsa051400.85945551
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85904778
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83635102
56Proteasome_Homo sapiens_hsa030500.81700450
57TNF signaling pathway_Homo sapiens_hsa046680.81547788
58Glutamatergic synapse_Homo sapiens_hsa047240.81427005
59Homologous recombination_Homo sapiens_hsa034400.80254679
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80248428
61Toxoplasmosis_Homo sapiens_hsa051450.78289167
62Mismatch repair_Homo sapiens_hsa034300.78222492
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77702263
64Fatty acid biosynthesis_Homo sapiens_hsa000610.75652984
65Non-homologous end-joining_Homo sapiens_hsa034500.75154697
66Staphylococcus aureus infection_Homo sapiens_hsa051500.74762707
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73148445
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72787198
69Endocytosis_Homo sapiens_hsa041440.72620212
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72106689
71Ras signaling pathway_Homo sapiens_hsa040140.72031930
72Ribosome_Homo sapiens_hsa030100.68101662
73Choline metabolism in cancer_Homo sapiens_hsa052310.66453352
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65966686
75Shigellosis_Homo sapiens_hsa051310.65593381
76Lysosome_Homo sapiens_hsa041420.65439235
77Antigen processing and presentation_Homo sapiens_hsa046120.64038698
78Viral myocarditis_Homo sapiens_hsa054160.63521562
79Serotonergic synapse_Homo sapiens_hsa047260.63130839
80Vitamin B6 metabolism_Homo sapiens_hsa007500.62891206
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62840782
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62619054
83Graft-versus-host disease_Homo sapiens_hsa053320.62581624
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.62096585
85Sulfur metabolism_Homo sapiens_hsa009200.62087379
86Cholinergic synapse_Homo sapiens_hsa047250.60960774
87Pancreatic cancer_Homo sapiens_hsa052120.59704071
88Malaria_Homo sapiens_hsa051440.58248067
89RNA degradation_Homo sapiens_hsa030180.57006862
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56432180
91Nucleotide excision repair_Homo sapiens_hsa034200.56244555
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56196390
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56064518
94Vibrio cholerae infection_Homo sapiens_hsa051100.55516615
95VEGF signaling pathway_Homo sapiens_hsa043700.55207008
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54252625
97Pertussis_Homo sapiens_hsa051330.50668482
98Butanoate metabolism_Homo sapiens_hsa006500.48037510
99Spliceosome_Homo sapiens_hsa030400.47797576
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47275970
101Base excision repair_Homo sapiens_hsa034100.45962471
102Hepatitis C_Homo sapiens_hsa051600.45958333
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45854371
104Renin secretion_Homo sapiens_hsa049240.45665143
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45505338
106Gap junction_Homo sapiens_hsa045400.45123833
107Non-small cell lung cancer_Homo sapiens_hsa052230.44167976
108Colorectal cancer_Homo sapiens_hsa052100.44062178
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43582092
110Dopaminergic synapse_Homo sapiens_hsa047280.43519158
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43380596
112Salmonella infection_Homo sapiens_hsa051320.42867442
113Phagosome_Homo sapiens_hsa041450.42725260
114Cell cycle_Homo sapiens_hsa041100.42681410
115Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41680457
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41065571
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40827511
118ErbB signaling pathway_Homo sapiens_hsa040120.40312644
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.39347470
120Morphine addiction_Homo sapiens_hsa050320.39317967
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.38855933
122Prolactin signaling pathway_Homo sapiens_hsa049170.38581410
123Salivary secretion_Homo sapiens_hsa049700.38262017
124One carbon pool by folate_Homo sapiens_hsa006700.37357134
125Acute myeloid leukemia_Homo sapiens_hsa052210.36669481
126Long-term potentiation_Homo sapiens_hsa047200.36601410
127Sphingolipid metabolism_Homo sapiens_hsa006000.35943184
128Type II diabetes mellitus_Homo sapiens_hsa049300.35253229
129MAPK signaling pathway_Homo sapiens_hsa040100.35237798
130Rap1 signaling pathway_Homo sapiens_hsa040150.34096258
131Pancreatic secretion_Homo sapiens_hsa049720.31802093
132Fanconi anemia pathway_Homo sapiens_hsa034600.31225073
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30693943
134Small cell lung cancer_Homo sapiens_hsa052220.28938183
135Glycerolipid metabolism_Homo sapiens_hsa005610.28564835
136mRNA surveillance pathway_Homo sapiens_hsa030150.27790372
137Gastric acid secretion_Homo sapiens_hsa049710.27526669
138Chronic myeloid leukemia_Homo sapiens_hsa052200.26149348
139Arachidonic acid metabolism_Homo sapiens_hsa005900.25663471
140RNA transport_Homo sapiens_hsa030130.25579045
141Fatty acid metabolism_Homo sapiens_hsa012120.24802496
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.24523539
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24084307
144HIF-1 signaling pathway_Homo sapiens_hsa040660.23036082
145Prostate cancer_Homo sapiens_hsa052150.22424273
146Endometrial cancer_Homo sapiens_hsa052130.22198572
147Pyrimidine metabolism_Homo sapiens_hsa002400.20818505
148Legionellosis_Homo sapiens_hsa051340.20730535
149Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20712439
150Protein export_Homo sapiens_hsa030600.18993373
151Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17804634
152N-Glycan biosynthesis_Homo sapiens_hsa005100.14063913
153Pentose phosphate pathway_Homo sapiens_hsa000300.13896595
154African trypanosomiasis_Homo sapiens_hsa051430.13746838
155Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.10452557
156Central carbon metabolism in cancer_Homo sapiens_hsa052300.09502789
157RNA polymerase_Homo sapiens_hsa030200.08816496
158Carbon metabolism_Homo sapiens_hsa012000.08430584

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