GPR151

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar to the galanin receptor subfamily of G protein-coupled receptors. The encoded protein is found predominantly in the central nervous system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of potassium ion transmembrane transporter activity (GO:1901018)8.62699702
2aggressive behavior (GO:0002118)6.65622363
3urinary tract smooth muscle contraction (GO:0014848)6.64461466
4cellular response to ATP (GO:0071318)6.45584965
5forebrain neuron development (GO:0021884)6.13291559
6sympathetic nervous system development (GO:0048485)5.97877699
7regulation of feeding behavior (GO:0060259)5.85762790
8positive regulation of bone remodeling (GO:0046852)5.72626441
9positive regulation of bone resorption (GO:0045780)5.72626441
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.53841550
11positive regulation of potassium ion transmembrane transport (GO:1901381)5.50227727
12drinking behavior (GO:0042756)5.50188255
13exogenous drug catabolic process (GO:0042738)5.41184569
14protein localization to microtubule (GO:0035372)5.35783409
15protein-cofactor linkage (GO:0018065)5.15260403
16behavioral response to ethanol (GO:0048149)5.14584468
17regulation of short-term neuronal synaptic plasticity (GO:0048172)4.96684228
18regulation of cytokine production involved in inflammatory response (GO:1900015)4.95201121
19regulation of glucocorticoid metabolic process (GO:0031943)4.90372438
20cell migration in hindbrain (GO:0021535)4.88176602
21chemosensory behavior (GO:0007635)4.85730852
22cranial nerve morphogenesis (GO:0021602)4.84491273
23synaptic transmission, dopaminergic (GO:0001963)4.84000988
24positive regulation of hair cycle (GO:0042635)4.83282871
25positive regulation of hair follicle development (GO:0051798)4.83282871
26regulation of glucocorticoid secretion (GO:2000849)4.74461604
27regulation of cell maturation (GO:1903429)4.60803646
28female gonad development (GO:0008585)4.60055957
29drug catabolic process (GO:0042737)4.56695525
30regulation of glutamate receptor signaling pathway (GO:1900449)4.55235222
31GDP-mannose metabolic process (GO:0019673)4.51930255
32nerve growth factor signaling pathway (GO:0038180)4.48153119
33cullin deneddylation (GO:0010388)4.46948885
34response to nitrosative stress (GO:0051409)4.46092678
35positive regulation of pseudopodium assembly (GO:0031274)4.44024294
36negative regulation of cell aging (GO:0090344)4.40224707
37negative regulation of calcium ion transport into cytosol (GO:0010523)4.38053631
38protein deneddylation (GO:0000338)4.33445374
39sialylation (GO:0097503)4.30651697
40synaptic vesicle exocytosis (GO:0016079)4.26104736
41protein localization to microtubule cytoskeleton (GO:0072698)4.22818498
42positive regulation of steroid hormone secretion (GO:2000833)4.18598481
43neuromuscular synaptic transmission (GO:0007274)4.17131225
44positive regulation of synaptic transmission, GABAergic (GO:0032230)4.16554253
45glycosphingolipid biosynthetic process (GO:0006688)4.15697541
46cAMP-mediated signaling (GO:0019933)4.13299305
47meiotic chromosome segregation (GO:0045132)4.08013358
48cellular response to ammonium ion (GO:0071242)4.03596195
49vocalization behavior (GO:0071625)4.01922546
50negative regulation of dendrite morphogenesis (GO:0050774)3.98396858
51regulation of pseudopodium assembly (GO:0031272)3.96125073
52glutamate secretion (GO:0014047)3.93822671
53sex differentiation (GO:0007548)3.92969784
54purinergic nucleotide receptor signaling pathway (GO:0035590)3.92624898
55keratinocyte development (GO:0003334)3.92507426
56neurotransmitter secretion (GO:0007269)3.92497844
57positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.90596128
58brain morphogenesis (GO:0048854)3.90559979
59DNA damage response, detection of DNA damage (GO:0042769)3.90043691
60synaptic vesicle maturation (GO:0016188)3.86736942
61activation of protein kinase A activity (GO:0034199)3.86422820
62regulation of corticosteroid hormone secretion (GO:2000846)3.86305796
63positive regulation of vascular permeability (GO:0043117)3.84100045
64positive regulation of potassium ion transport (GO:0043268)3.81331812
65cellular response to nicotine (GO:0071316)3.81033491
66neuron cell-cell adhesion (GO:0007158)3.79654293
67regulation of synaptic vesicle exocytosis (GO:2000300)3.78811785
68DNA strand renaturation (GO:0000733)3.76021141
69oligosaccharide biosynthetic process (GO:0009312)3.75524888
70facial nerve structural organization (GO:0021612)3.74568672
71regulation of potassium ion transmembrane transporter activity (GO:1901016)3.71191120
72behavioral response to pain (GO:0048266)3.70506260
73central nervous system neuron development (GO:0021954)3.69315197
74positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.64934418
75preassembly of GPI anchor in ER membrane (GO:0016254)3.64026674
76protein localization to cytoskeleton (GO:0044380)3.62946775
77G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.62887888
78negative regulation of microtubule polymerization (GO:0031115)3.62810454
79neurotransmitter uptake (GO:0001504)3.60585104
80secondary metabolite biosynthetic process (GO:0044550)3.60575987
81glucosamine-containing compound catabolic process (GO:1901072)3.59499351
82response to ATP (GO:0033198)3.58692374
83regulation of neurotransmitter uptake (GO:0051580)3.53992797
84negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.53924997
85central nervous system projection neuron axonogenesis (GO:0021952)3.53052874
86neurotransmitter biosynthetic process (GO:0042136)3.48991387
87protein localization to synapse (GO:0035418)3.46908836
88neuron-neuron synaptic transmission (GO:0007270)3.46092407
89positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.45507126
90peristalsis (GO:0030432)3.43614748
91regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.43442227
92regulation of synapse structural plasticity (GO:0051823)3.42332042
93regulation of hair follicle development (GO:0051797)3.41735250
94regulation of potassium ion transmembrane transport (GO:1901379)3.36637086
95synaptic vesicle docking involved in exocytosis (GO:0016081)3.36015583
96regulation of skeletal muscle contraction (GO:0014819)3.35237847
97regulation of axon regeneration (GO:0048679)3.35187625
98regulation of neuron projection regeneration (GO:0070570)3.35187625
99base-excision repair, AP site formation (GO:0006285)3.32851620
1003-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.31405958
101purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.31405958
102proline transport (GO:0015824)3.29774026
103positive regulation of cation channel activity (GO:2001259)3.28894587
104regulation of synaptic vesicle transport (GO:1902803)3.28814319
105negative regulation of dendrite development (GO:2000171)3.28814299
106purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.28378783
107ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.28378783
108nucleoside bisphosphate biosynthetic process (GO:0033866)3.28378783
109pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.27823240
110regulation of respiratory gaseous exchange (GO:0043576)3.26141386
111negative regulation of Rho protein signal transduction (GO:0035024)3.25580088
112positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.25452618
113regulation of synaptic transmission, glutamatergic (GO:0051966)3.24781155
114establishment of mitochondrion localization (GO:0051654)3.22718218
115neuronal action potential propagation (GO:0019227)3.22521533
116amino sugar catabolic process (GO:0046348)3.20810407
117negative regulation of neurotransmitter transport (GO:0051589)3.20120804
118microtubule depolymerization (GO:0007019)3.19885451
119regulation of dopamine metabolic process (GO:0042053)3.19182618
120regulation of catecholamine metabolic process (GO:0042069)3.19182618
121regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.18303281
122regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.15901772
123pyrimidine nucleobase catabolic process (GO:0006208)3.15610409
124neurotransmitter transport (GO:0006836)3.14253034
125response to auditory stimulus (GO:0010996)3.13691962
126regulation of neurotransmitter levels (GO:0001505)3.13641642
127ionotropic glutamate receptor signaling pathway (GO:0035235)3.13205356
128regulation of response to food (GO:0032095)3.12827725
129protein import into peroxisome matrix (GO:0016558)3.12044933
130glutamate receptor signaling pathway (GO:0007215)3.10904520
131negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.10813139
132regulation of NFAT protein import into nucleus (GO:0051532)3.10574685
133adult feeding behavior (GO:0008343)3.09089810
134dicarboxylic acid catabolic process (GO:0043649)3.08899292
135detection of light stimulus involved in sensory perception (GO:0050962)3.07260488
136detection of light stimulus involved in visual perception (GO:0050908)3.07260488
137response to pain (GO:0048265)3.06883630
138insulin secretion (GO:0030073)3.06511722
139gamma-aminobutyric acid transport (GO:0015812)3.06064734
140locomotory exploration behavior (GO:0035641)3.04412470
141regulation of vesicle fusion (GO:0031338)3.04305998
142peptidyl-cysteine modification (GO:0018198)3.03349970
143positive regulation of synapse assembly (GO:0051965)3.02965769
144multicellular organismal response to stress (GO:0033555)2.99772735
145cyclic-nucleotide-mediated signaling (GO:0019935)2.99520567
146synaptic vesicle endocytosis (GO:0048488)2.98979941
147regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.98185811
148response to cocaine (GO:0042220)2.96029676
149exploration behavior (GO:0035640)2.95904934
150pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.95787342
151regulation of neuronal synaptic plasticity (GO:0048168)2.95350211
152regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.94037313
153behavioral fear response (GO:0001662)2.92802288
154behavioral defense response (GO:0002209)2.92802288
155arginine catabolic process (GO:0006527)2.92352549
156vesicle transport along microtubule (GO:0047496)2.92076279
157negative regulation of cell size (GO:0045792)2.91051759
158presynaptic membrane organization (GO:0097090)2.90877730
159negative chemotaxis (GO:0050919)2.90430690
160neuronal action potential (GO:0019228)2.88590245
161adenosine receptor signaling pathway (GO:0001973)2.88555159
162regulation of potassium ion transport (GO:0043266)2.87305077
163amine biosynthetic process (GO:0009309)2.85821788
164regulation of protein kinase A signaling (GO:0010738)2.85741047
165protein insertion into membrane (GO:0051205)2.85276515
166prepulse inhibition (GO:0060134)2.84766277
167regulation of endocrine process (GO:0044060)2.84439570
168neuromuscular process controlling posture (GO:0050884)2.84129070
169DNA replication checkpoint (GO:0000076)2.83665294
170serotonin receptor signaling pathway (GO:0007210)2.83282882
171negative regulation of heart rate (GO:0010459)2.82582715
172transferrin transport (GO:0033572)2.82354477
173synaptic transmission, glutamatergic (GO:0035249)2.81782401
174detection of temperature stimulus involved in sensory perception (GO:0050961)2.81481052
175detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.81481052
176cellular biogenic amine biosynthetic process (GO:0042401)2.80529694
177neurotransmitter metabolic process (GO:0042133)2.80521437
178regulation of cilium movement (GO:0003352)2.80240436
179organelle transport along microtubule (GO:0072384)2.79715363
180central nervous system neuron axonogenesis (GO:0021955)2.77110578
181cornea development in camera-type eye (GO:0061303)2.75846682
182histone H2A acetylation (GO:0043968)2.75506240
183positive regulation of protein homodimerization activity (GO:0090073)2.74346459
184L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.72092258
185cellular response to nerve growth factor stimulus (GO:1990090)2.71016203
186response to nerve growth factor (GO:1990089)2.71016203
187negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.69138266
188positive regulation of tissue remodeling (GO:0034105)2.68691058
189microtubule polymerization or depolymerization (GO:0031109)2.67881502
190cranial nerve structural organization (GO:0021604)2.67379275
191tRNA modification (GO:0006400)2.66842958

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.85857001
2GBX2_23144817_ChIP-Seq_PC3_Human4.38124643
3EZH2_22144423_ChIP-Seq_EOC_Human3.89965881
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.31258626
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.19017592
6TAF15_26573619_Chip-Seq_HEK293_Human3.15914867
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89635246
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.78635672
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.76661038
10REST_21632747_ChIP-Seq_MESCs_Mouse2.74384224
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.72589130
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.65525926
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.62990397
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.59272971
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58777969
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53751975
17ELK4_26923725_Chip-Seq_MESODERM_Mouse2.53149849
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.52522182
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49990842
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47526322
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47526322
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.47470907
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42914410
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.39117072
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34608416
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.22164323
27EWS_26573619_Chip-Seq_HEK293_Human2.17419172
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14602713
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13616349
30SMAD4_21799915_ChIP-Seq_A2780_Human2.11638329
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.11260513
32PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse2.11249233
33PCGF2_27294783_Chip-Seq_NPCs_Mouse2.05876073
34DROSHA_22980978_ChIP-Seq_HELA_Human2.05181881
35AR_21572438_ChIP-Seq_LNCaP_Human2.04472040
36EZH2_27304074_Chip-Seq_ESCs_Mouse2.02859176
37FUS_26573619_Chip-Seq_HEK293_Human2.01529956
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97576397
39DCP1A_22483619_ChIP-Seq_HELA_Human1.94037205
40RARB_27405468_Chip-Seq_BRAIN_Mouse1.91496367
41XRN2_22483619_ChIP-Seq_HELA_Human1.90149417
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88503974
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87645918
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.85658908
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82100922
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78326742
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78112115
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.77203585
49PKCTHETA_26484144_Chip-Seq_BREAST_Human1.77166890
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.75096406
51P300_19829295_ChIP-Seq_ESCs_Human1.71367827
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.70684038
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69973798
54AR_25329375_ChIP-Seq_VCAP_Human1.69931340
55CTCF_27219007_Chip-Seq_ERYTHROID_Human1.68969136
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67193917
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.65676873
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65452493
59E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.64739539
60MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.62160875
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59442666
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56828950
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56178087
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54980846
65* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54612819
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53851387
67TP53_22573176_ChIP-Seq_HFKS_Human1.53695428
68MAF_26560356_Chip-Seq_TH2_Human1.53466097
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.53217704
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52624537
71CBX2_22325352_ChIP-Seq_293T-Rex_Human1.52002583
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49145929
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48041936
74RBPJ_21746931_ChIP-Seq_IB4_Human1.46065330
75KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.43543366
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43140025
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42609215
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.42358579
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40764452
80* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40756616
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38991028
82ETS1_20019798_ChIP-Seq_JURKAT_Human1.38604449
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38487770
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38316604
85P53_22387025_ChIP-Seq_ESCs_Mouse1.38055643
86PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.37191061
87ZNF274_21170338_ChIP-Seq_K562_Hela1.37190591
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36996381
89VDR_23849224_ChIP-Seq_CD4+_Human1.35051676
90WT1_19549856_ChIP-ChIP_CCG9911_Human1.35017255
91VDR_22108803_ChIP-Seq_LS180_Human1.31792276
92POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31532433
93FOXM1_23109430_ChIP-Seq_U2OS_Human1.31299249
94E2F1_20622854_ChIP-Seq_HELA_Human1.31065454
95PHF8_20622854_ChIP-Seq_HELA_Human1.30980123
96IGF1R_20145208_ChIP-Seq_DFB_Human1.29440885
97GABP_19822575_ChIP-Seq_HepG2_Human1.28825961
98ERG_21242973_ChIP-ChIP_JURKAT_Human1.27409098
99ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26835170
100SRF_21415370_ChIP-Seq_HL-1_Mouse1.26308243
101STAT3_23295773_ChIP-Seq_U87_Human1.26188128
102DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26145215
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25633389
104ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24919499
105P68_20966046_ChIP-Seq_HELA_Human1.22792443
106FOXP1_21924763_ChIP-Seq_HESCs_Human1.22473280
107ETV1_20927104_ChIP-Seq_GIST48_Human1.21127532
108EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.20913635
109* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20459166
110GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20051461
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19874295
112RXR_22108803_ChIP-Seq_LS180_Human1.18745428
113VDR_21846776_ChIP-Seq_THP-1_Human1.17263056
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17141294
115* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17094950
116AHR_22903824_ChIP-Seq_MCF-7_Human1.16833791
117SOX2_18555785_Chip-Seq_ESCs_Mouse1.16778096
118SMAD3_21741376_ChIP-Seq_EPCs_Human1.15952555
119RUNX1_27457419_Chip-Seq_LIVER_Mouse1.14818153
120PRDM14_20953172_ChIP-Seq_ESCs_Human1.14371846
121KDM2B_26808549_Chip-Seq_REH_Human1.14077410
122STAT3_18555785_Chip-Seq_ESCs_Mouse1.13530674
123RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12178244
124RARB_24833708_ChIP-Seq_LIVER_Mouse1.11699630
125* JUN_21703547_ChIP-Seq_K562_Human1.11541726
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10543453
127SMAD3_21741376_ChIP-Seq_ESCs_Human1.10363416
128PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10084583
129RNF2_27304074_Chip-Seq_NSC_Mouse1.09640889
130YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09534592
131EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08948059
132MYC_19829295_ChIP-Seq_ESCs_Human1.08558346
133GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.08511466
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08391333
135TET1_21451524_ChIP-Seq_MESCs_Mouse1.08170364
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08088148
137ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07741608
138CBP_20019798_ChIP-Seq_JUKART_Human1.07591059
139IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07591059
140TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07423191
141E2F1_18555785_Chip-Seq_ESCs_Mouse1.07149067
142AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07056174
143RING1B_27294783_Chip-Seq_ESCs_Mouse1.06931282
144P300_18555785_Chip-Seq_ESCs_Mouse1.05622339
145NANOG_18555785_Chip-Seq_ESCs_Mouse1.05107036
146TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04571268
147GABP_17652178_ChIP-ChIP_JURKAT_Human1.04438177
148RARA_24833708_ChIP-Seq_LIVER_Mouse1.03958512
149TCF4_23295773_ChIP-Seq_U87_Human1.03732106
150BCOR_27268052_Chip-Seq_Bcells_Human1.03295263
151TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03031439
152SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01798554
153RUNX2_22187159_ChIP-Seq_PCA_Human1.01009027
154* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00863359
155PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00714388
156ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99814957
157MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99651817
158PHF8_20622853_ChIP-Seq_HELA_Human0.99565407
159* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99546909
160GATA6_21074721_ChIP-Seq_CACO-2_Human0.98970824
161ERA_21632823_ChIP-Seq_H3396_Human0.98579452
162CMYC_18555785_Chip-Seq_ESCs_Mouse0.98540019
163NOTCH1_21737748_ChIP-Seq_TLL_Human0.98503760
164NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98153733
165TP53_18474530_ChIP-ChIP_U2OS_Human0.97794753
166ARNT_22903824_ChIP-Seq_MCF-7_Human0.97356581
167AR_19668381_ChIP-Seq_PC3_Human0.96509915
168* CTCF_20526341_ChIP-Seq_ESCs_Human0.96346146
169P53_21459846_ChIP-Seq_SAOS-2_Human0.96263591
170CRX_20693478_ChIP-Seq_RETINA_Mouse0.95695747
171CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95578181
172EZH2_27294783_Chip-Seq_NPCs_Mouse0.95153835
173FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.94410430
174RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94382112
175TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94286971
176* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93947897
177SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93400175
178* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.92885759
179SMAD1_18555785_Chip-Seq_ESCs_Mouse0.92565067
180SMAD_19615063_ChIP-ChIP_OVARY_Human0.92097763
181RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91073982
182EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90143535
183CTCF_27219007_Chip-Seq_Bcells_Human0.89967550
184P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86626806
185EP300_21415370_ChIP-Seq_HL-1_Mouse0.85338955

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation6.78250890
2MP0004858_abnormal_nervous_system6.63768352
3MP0002735_abnormal_chemical_nociception5.33433327
4MP0001968_abnormal_touch/_nociception5.19724737
5MP0001188_hyperpigmentation4.98891835
6MP0002163_abnormal_gland_morphology4.44405034
7MP0001986_abnormal_taste_sensitivity4.40622742
8MP0004859_abnormal_synaptic_plasticity4.04356522
9MP0005174_abnormal_tail_pigmentation3.70457258
10MP0003136_yellow_coat_color3.52022458
11MP0005646_abnormal_pituitary_gland3.25265544
12MP0001502_abnormal_circadian_rhythm3.12312619
13MP0005379_endocrine/exocrine_gland_phen3.04349408
14MP0008058_abnormal_DNA_repair2.95619636
15MP0002734_abnormal_mechanical_nocicepti2.94637436
16MP0003635_abnormal_synaptic_transmissio2.89752064
17MP0003880_abnormal_central_pattern2.77738487
18MP0009745_abnormal_behavioral_response2.75459234
19MP0002736_abnormal_nociception_after2.75092231
20MP0002733_abnormal_thermal_nociception2.70670960
21MP0004270_analgesia2.69820739
22MP0005409_darkened_coat_color2.43164102
23MP0005084_abnormal_gallbladder_morpholo2.38109873
24MP0001970_abnormal_pain_threshold2.36346048
25MP0002064_seizures2.33085012
26MP0001529_abnormal_vocalization2.30859866
27MP0003646_muscle_fatigue2.29861777
28MP0005645_abnormal_hypothalamus_physiol2.28148862
29MP0002272_abnormal_nervous_system2.23371577
30MP0002063_abnormal_learning/memory/cond2.21055703
31MP0002572_abnormal_emotion/affect_behav2.17212998
32MP0005551_abnormal_eye_electrophysiolog2.11293384
33MP0004147_increased_porphyrin_level2.08841629
34MP0008872_abnormal_physiological_respon2.07994030
35MP0009046_muscle_twitch2.00604466
36MP0001440_abnormal_grooming_behavior1.99878454
37MP0001501_abnormal_sleep_pattern1.96822248
38MP0002184_abnormal_innervation1.94709730
39MP0005423_abnormal_somatic_nervous1.92963456
40MP0006276_abnormal_autonomic_nervous1.92058342
41MP0002638_abnormal_pupillary_reflex1.89456481
42MP0008875_abnormal_xenobiotic_pharmacok1.86952627
43MP0003693_abnormal_embryo_hatching1.74308963
44MP0003303_peritoneal_inflammation1.63180221
45MP0008775_abnormal_heart_ventricle1.60617667
46MP0002067_abnormal_sensory_capabilities1.59263051
47MP0006292_abnormal_olfactory_placode1.54814323
48MP0004811_abnormal_neuron_physiology1.52657767
49MP0004484_altered_response_of1.51204290
50MP0004233_abnormal_muscle_weight1.50708252
51MP0004924_abnormal_behavior1.43907947
52MP0005386_behavior/neurological_phenoty1.43907947
53MP0000427_abnormal_hair_cycle1.43782462
54MP0001486_abnormal_startle_reflex1.42519420
55MP0003329_amyloid_beta_deposits1.41164494
56MP0003787_abnormal_imprinting1.39085520
57MP0004130_abnormal_muscle_cell1.37788330
58MP0000955_abnormal_spinal_cord1.35281768
59MP0003045_fibrosis1.34840473
60MP0005187_abnormal_penis_morphology1.33858200
61MP0005310_abnormal_salivary_gland1.32574048
62MP0010094_abnormal_chromosome_stability1.32002932
63MP0005332_abnormal_amino_acid1.27653011
64MP0004742_abnormal_vestibular_system1.26419802
65MP0003111_abnormal_nucleus_morphology1.24492062
66MP0002837_dystrophic_cardiac_calcinosis1.23476773
67MP0003122_maternal_imprinting1.21672464
68MP0002653_abnormal_ependyma_morphology1.20959897
69MP0002751_abnormal_autonomic_nervous1.18474410
70MP0002090_abnormal_vision1.14734459
71MP0000015_abnormal_ear_pigmentation1.13832355
72MP0004142_abnormal_muscle_tone1.13550838
73MP0005248_abnormal_Harderian_gland1.10360983
74MP0002557_abnormal_social/conspecific_i1.08995704
75MP0005451_abnormal_body_composition1.08808595
76MP0000751_myopathy1.08077536
77MP0009780_abnormal_chondrocyte_physiolo1.07000677
78MP0000750_abnormal_muscle_regeneration1.04978228
79MP0004883_abnormal_blood_vessel1.03537591
80MP0002095_abnormal_skin_pigmentation1.02328175
81MP0000778_abnormal_nervous_system1.01222257
82MP0001661_extended_life_span1.00705304
83MP0002882_abnormal_neuron_morphology0.98130966
84MP0010386_abnormal_urinary_bladder0.97754291
85MP0003077_abnormal_cell_cycle0.96637789
86MP0003195_calcinosis0.95447657
87MP0002876_abnormal_thyroid_physiology0.94538712
88MP0000538_abnormal_urinary_bladder0.90752987
89MP0004084_abnormal_cardiac_muscle0.89967742
90MP0008874_decreased_physiological_sensi0.89197491
91MP0005253_abnormal_eye_physiology0.88031029
92MP0005167_abnormal_blood-brain_barrier0.87856866
93MP0005410_abnormal_fertilization0.87495993
94MP0004043_abnormal_pH_regulation0.86857440
95MP0002066_abnormal_motor_capabilities/c0.86333546
96MP0000604_amyloidosis0.84030592
97MP0003631_nervous_system_phenotype0.83754149
98MP0003633_abnormal_nervous_system0.82920255
99MP0004215_abnormal_myocardial_fiber0.82277735
100MP0001984_abnormal_olfaction0.81183425
101MP0003755_abnormal_palate_morphology0.80331813
102MP0004145_abnormal_muscle_electrophysio0.80108686
103MP0003632_abnormal_nervous_system0.78710381
104MP0002909_abnormal_adrenal_gland0.78502137
105MP0005083_abnormal_biliary_tract0.78275246
106MP0003890_abnormal_embryonic-extraembry0.78241094
107MP0001324_abnormal_eye_pigmentation0.77110321
108MP0004036_abnormal_muscle_relaxation0.75638786
109MP0008932_abnormal_embryonic_tissue0.75592546
110MP0008569_lethality_at_weaning0.75574188
111MP0005501_abnormal_skin_physiology0.75482023
112MP0001664_abnormal_digestion0.75021994
113MP0000465_gastrointestinal_hemorrhage0.68894364
114MP0002069_abnormal_eating/drinking_beha0.68022560
115MP0008877_abnormal_DNA_methylation0.65831783
116MP0003183_abnormal_peptide_metabolism0.65383557
117MP0001765_abnormal_ion_homeostasis0.63860130
118MP0003941_abnormal_skin_development0.63618312
119MP0005647_abnormal_sex_gland0.62990423
120MP0005623_abnormal_meninges_morphology0.62583839
121MP0003879_abnormal_hair_cell0.61165539
122MP0004133_heterotaxia0.61055777
123MP0001905_abnormal_dopamine_level0.58555213
124MP0005448_abnormal_energy_balance0.56675984
125MP0009278_abnormal_bone_marrow0.56660938
126MP0001177_atelectasis0.55934744
127MP0010770_preweaning_lethality0.55670554
128MP0002082_postnatal_lethality0.55670554
129MP0003011_delayed_dark_adaptation0.53769301
130MP0004381_abnormal_hair_follicle0.52226988
131MP0006138_congestive_heart_failure0.52198681
132MP0001299_abnormal_eye_distance/0.51726247
133MP0003453_abnormal_keratinocyte_physiol0.51194270
134MP0010769_abnormal_survival0.51142886
135MP0002752_abnormal_somatic_nervous0.50908104
136MP0000470_abnormal_stomach_morphology0.50772615
137MP0001348_abnormal_lacrimal_gland0.49891755
138MP0001191_abnormal_skin_condition0.49643952
139MP0002229_neurodegeneration0.49349632
140MP0010768_mortality/aging0.48721130
141MP0002152_abnormal_brain_morphology0.48288825
142MP0001756_abnormal_urination0.47352475
143MP0002102_abnormal_ear_morphology0.45964587
144MP0003634_abnormal_glial_cell0.45385150
145MP0002332_abnormal_exercise_endurance0.45365594
146MP0005394_taste/olfaction_phenotype0.45019824
147MP0005499_abnormal_olfactory_system0.45019824
148MP0001881_abnormal_mammary_gland0.43303122
149MP0005165_increased_susceptibility_to0.41018404
150MP0001943_abnormal_respiration0.40495176
151MP0005535_abnormal_body_temperature0.40217018
152MP0004085_abnormal_heartbeat0.39464194
153MP0002269_muscular_atrophy0.37707023
154MP0010771_integument_phenotype0.35975123
155MP0000372_irregular_coat_pigmentation0.35616156

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.83322442
2Poikiloderma (HP:0001029)5.29815640
3Ulnar claw (HP:0001178)5.23232477
4Focal seizures (HP:0007359)4.90482044
5Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.79548707
6Focal motor seizures (HP:0011153)4.48311876
7Progressive cerebellar ataxia (HP:0002073)4.43328652
8Generalized aminoaciduria (HP:0002909)4.42693081
9Retinal dysplasia (HP:0007973)4.39427263
10Atonic seizures (HP:0010819)4.25609237
11Pheochromocytoma (HP:0002666)4.25529623
12Attenuation of retinal blood vessels (HP:0007843)4.24351918
13Action tremor (HP:0002345)4.14302735
14Neuroendocrine neoplasm (HP:0100634)4.06029841
15Rib fusion (HP:0000902)3.96425324
16Abnormality of pain sensation (HP:0010832)3.87899026
17Impaired pain sensation (HP:0007328)3.87899026
18Akinesia (HP:0002304)3.82708392
19Abnormality of alanine metabolism (HP:0010916)3.80670951
20Hyperalaninemia (HP:0003348)3.80670951
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.80670951
22Myotonia (HP:0002486)3.79196301
23Neonatal respiratory distress (HP:0002643)3.69659847
24Ankle clonus (HP:0011448)3.64755122
25Patellar aplasia (HP:0006443)3.64212197
26Visual hallucinations (HP:0002367)3.63592684
27Insidious onset (HP:0003587)3.57204774
28Termporal pattern (HP:0011008)3.57204774
29Abnormality of the vocal cords (HP:0008777)3.47439429
30Abnormality of the labia minora (HP:0012880)3.39499260
31Urinary urgency (HP:0000012)3.38158165
32Febrile seizures (HP:0002373)3.36605612
33Rectovaginal fistula (HP:0000143)3.36478324
34Rectal fistula (HP:0100590)3.36478324
35Congenital stationary night blindness (HP:0007642)3.32384155
36Abnormality of the corticospinal tract (HP:0002492)3.31612368
37Aplasia/Hypoplasia of the patella (HP:0006498)3.30605759
38Areflexia of lower limbs (HP:0002522)3.30015335
39Abnormal albumin level (HP:0012116)3.21933992
40Hypoalbuminemia (HP:0003073)3.21933992
41Distal lower limb muscle weakness (HP:0009053)3.20482028
42Molar tooth sign on MRI (HP:0002419)3.19142886
43Abnormality of midbrain morphology (HP:0002418)3.19142886
44Facial diplegia (HP:0001349)3.15681585
45Failure to thrive in infancy (HP:0001531)3.14976829
46Dysautonomia (HP:0002459)3.14729316
47Generalized hypotonia (HP:0001290)3.14078441
48Absence seizures (HP:0002121)3.13577191
49Abnormal hair whorl (HP:0010721)3.12297681
50Poor suck (HP:0002033)3.11857385
51Intestinal fistula (HP:0100819)3.08152727
52Squamous cell carcinoma (HP:0002860)3.07193541
53Anteriorly placed anus (HP:0001545)3.05183264
54Vaginal fistula (HP:0004320)3.04942330
55Dialeptic seizures (HP:0011146)3.04213422
56Testicular atrophy (HP:0000029)2.99812583
57Scanning speech (HP:0002168)2.99080764
58Recurrent corneal erosions (HP:0000495)2.98736716
59Increased hepatocellular lipid droplets (HP:0006565)2.97461733
60Chorioretinal atrophy (HP:0000533)2.96998930
61Annular pancreas (HP:0001734)2.96257455
62Generalized tonic-clonic seizures (HP:0002069)2.95952911
63Epileptic encephalopathy (HP:0200134)2.94331711
64Lipid accumulation in hepatocytes (HP:0006561)2.93816638
65Orthostatic hypotension (HP:0001278)2.89803676
66Urinary bladder sphincter dysfunction (HP:0002839)2.88571180
67Impaired vibration sensation in the lower limbs (HP:0002166)2.88436353
68Spastic gait (HP:0002064)2.82621541
69Arthropathy (HP:0003040)2.81402093
70Oligomenorrhea (HP:0000876)2.81281462
71Absent forearm bone (HP:0003953)2.79938232
72Aplasia involving forearm bones (HP:0009822)2.79938232
73Truncal ataxia (HP:0002078)2.79642432
74Bony spicule pigmentary retinopathy (HP:0007737)2.78819259
75Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.75594246
76Supranuclear gaze palsy (HP:0000605)2.72276386
77Dysdiadochokinesis (HP:0002075)2.70559913
78Hammertoe (HP:0001765)2.68331060
79Epileptiform EEG discharges (HP:0011182)2.67491399
80Abnormality of the ischium (HP:0003174)2.66194354
81Hyporeflexia of lower limbs (HP:0002600)2.64973325
823-Methylglutaconic aciduria (HP:0003535)2.62355197
83Polyphagia (HP:0002591)2.61346307
84Foot dorsiflexor weakness (HP:0009027)2.60624804
85Hypoplastic pelvis (HP:0008839)2.60027815
86Aqueductal stenosis (HP:0002410)2.59527544
87EEG with generalized epileptiform discharges (HP:0011198)2.58074638
88Neoplasm of the peripheral nervous system (HP:0100007)2.56777113
89Hypsarrhythmia (HP:0002521)2.56551279
90Nasal speech (HP:0001611)2.56492170
91Depression (HP:0000716)2.54777768
92Pendular nystagmus (HP:0012043)2.54347587
93Renal Fanconi syndrome (HP:0001994)2.52959899
94Hyperventilation (HP:0002883)2.52791993
95Increased intramyocellular lipid droplets (HP:0012240)2.52630216
96Reduced antithrombin III activity (HP:0001976)2.52025645
97Distal sensory impairment (HP:0002936)2.51588987
98Mesangial abnormality (HP:0001966)2.51087890
99Dysmetria (HP:0001310)2.49700222
100Facial hemangioma (HP:0000329)2.47510348
101Enlarged epiphyses (HP:0010580)2.45900206
102Abnormal eating behavior (HP:0100738)2.45516465
103Dyschromatopsia (HP:0007641)2.44362010
104Lower limb muscle weakness (HP:0007340)2.42726650
105Hypoventilation (HP:0002791)2.42722976
106Lower limb amyotrophy (HP:0007210)2.41934709
107Abnormality of renal resorption (HP:0011038)2.40816196
108Abnormality of the foot musculature (HP:0001436)2.40289767
109Delusions (HP:0000746)2.40215577
110Steppage gait (HP:0003376)2.37799763
111Anxiety (HP:0000739)2.37410335
112Decreased motor nerve conduction velocity (HP:0003431)2.36396186
113Abnormality of the lower motor neuron (HP:0002366)2.35958938
114Postural instability (HP:0002172)2.35624267
115Fibular aplasia (HP:0002990)2.34752905
116Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.33711991
117Hypoplasia of the brainstem (HP:0002365)2.33611517
118Aplasia/Hypoplasia of the brainstem (HP:0007362)2.33611517
119Fetal akinesia sequence (HP:0001989)2.32326707
120Abnormality of dental color (HP:0011073)2.31921708
121Aplasia/hypoplasia of the uterus (HP:0008684)2.31303739
122Birth length less than 3rd percentile (HP:0003561)2.29479447
123Increased muscle lipid content (HP:0009058)2.26461182
124Cerebral inclusion bodies (HP:0100314)2.25072166
125Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.24646161
126Abnormality of the intrinsic pathway (HP:0010989)2.24430035
127Abolished electroretinogram (ERG) (HP:0000550)2.22951616
128Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.22832875
129Brushfield spots (HP:0001088)2.22513379
130Diminished movement (HP:0002374)2.22077896
131Hepatocellular necrosis (HP:0001404)2.21948568
132Abnormality of DNA repair (HP:0003254)2.19082086
133Thin bony cortex (HP:0002753)2.18577351
134Hypothermia (HP:0002045)2.18450933
135Bradycardia (HP:0001662)2.15622192
136Decreased electroretinogram (ERG) amplitude (HP:0000654)2.13895103
137Psychosis (HP:0000709)2.13525569
138Hepatic necrosis (HP:0002605)2.13467017
139Upper limb muscle weakness (HP:0003484)2.12950967
140Popliteal pterygium (HP:0009756)2.11768491
141Drooling (HP:0002307)2.11535848
142Excessive salivation (HP:0003781)2.11535848
143Amblyopia (HP:0000646)2.11347534
144Morphological abnormality of the pyramidal tract (HP:0002062)2.10432796
145Absent radius (HP:0003974)2.09798568
146Diplopia (HP:0000651)2.08790614
147Abnormality of binocular vision (HP:0011514)2.08790614
148Flat occiput (HP:0005469)2.07037977
149Decreased central vision (HP:0007663)2.06728499
150Specific learning disability (HP:0001328)2.05566197
151Narrow nasal bridge (HP:0000446)2.05181986
152Abnormal social behavior (HP:0012433)2.04391121
153Impaired social interactions (HP:0000735)2.04391121
154Hypercortisolism (HP:0001578)2.03277257
155Lissencephaly (HP:0001339)2.02734463
156Hypophosphatemic rickets (HP:0004912)2.01370359
157Stomach cancer (HP:0012126)2.01326054
158Abnormality of the hepatic vasculature (HP:0006707)2.01078781
159Clonus (HP:0002169)2.00677750
160Testicular neoplasm (HP:0010788)1.99769375
161Epidermoid cyst (HP:0200040)1.98958476
162Onion bulb formation (HP:0003383)1.98819921
163Ulnar bowing (HP:0003031)1.98175138
164Broad-based gait (HP:0002136)1.98110014
165Oligodactyly (hands) (HP:0001180)1.97621210
166Premature graying of hair (HP:0002216)1.96912824
167Microretrognathia (HP:0000308)1.95972122
168Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95144758
169Abnormal protein N-linked glycosylation (HP:0012347)1.95144758
170Abnormal protein glycosylation (HP:0012346)1.95144758
171Abnormal glycosylation (HP:0012345)1.95144758
172Anhidrosis (HP:0000970)1.94988862
173Increased number of teeth (HP:0011069)1.94635463
174Absent speech (HP:0001344)1.93785510
175Malignant hyperthermia (HP:0002047)1.92738536
176Progressive inability to walk (HP:0002505)1.91789527
177Degeneration of the lateral corticospinal tracts (HP:0002314)1.90966037
178Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.90966037
179Hyperthyroidism (HP:0000836)1.90530977
180Slow progression (HP:0003677)1.89772620
181Poor eye contact (HP:0000817)1.88226717
182Aplasia of the musculature (HP:0100854)1.88019107
183Bradykinesia (HP:0002067)1.87357467
184Distal lower limb amyotrophy (HP:0008944)1.85824952
185Tubular atrophy (HP:0000092)1.85597088
186Absent thumb (HP:0009777)1.83507203
187Type I transferrin isoform profile (HP:0003642)1.83416347
188Esotropia (HP:0000565)1.82912877
189Abnormal autonomic nervous system physiology (HP:0012332)1.82267772
190Epiphyseal stippling (HP:0010655)1.81369250
191High anterior hairline (HP:0009890)1.80372110

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.40486332
2STK163.95453323
3NTRK33.91255296
4STK243.32980146
5MATK3.23509580
6MAP3K93.18853583
7MAPKAPK33.13340734
8MAP3K43.01358711
9MINK13.01284315
10MAPK152.96699536
11CSNK1A1L2.92459556
12CSNK1G32.91016869
13MAP3K122.81866097
14WNK42.70099077
15CSNK1G12.24841958
16MAP2K72.21749189
17LIMK12.17971724
18CAMK1D2.17649884
19FRK2.08051721
20ACVR1B2.07842419
21FER2.00546254
22TRIM282.00147391
23CAMKK21.95565457
24MAP2K41.82573627
25GRK51.68738712
26RIPK41.64973763
27ZAK1.63819140
28CAMK1G1.60702711
29MAPK131.57508014
30ARAF1.56710664
31MARK11.56695241
32CCNB11.56554161
33PAK61.50503031
34NTRK21.49567111
35MST41.49264671
36LATS21.46754273
37PLK21.42168603
38GRK71.42114402
39NTRK11.41477009
40DAPK21.38834950
41KSR21.37452120
42BCR1.32517433
43SGK2231.31197220
44SGK4941.31197220
45DAPK11.30802760
46CAMKK11.30793384
47BLK1.30527350
48CAMK41.27705723
49PRKCE1.27645397
50UHMK11.26658057
51NME11.25911933
52CDC71.24782622
53LMTK21.24573288
54EPHA31.24492654
55EPHA41.24208445
56CDK51.22015256
57PRKCG1.18839716
58AKT31.09338924
59CAMK11.07049892
60ADRBK11.06184984
61TESK11.04854847
62MAP2K11.04844243
63PAK31.01997944
64CAMK2A1.01242149
65KSR10.99035939
66PHKG20.98928725
67PHKG10.98928725
68TESK20.97302596
69SGK20.95540722
70SIK20.94181436
71ATR0.93513266
72BMPR1B0.89749525
73MAP3K130.89340025
74MUSK0.88833258
75WNK30.82953427
76SIK30.81652808
77RET0.80581547
78ALK0.76634931
79MAP3K110.75667116
80CSNK1D0.74009802
81ADRBK20.73849543
82GRK10.70418687
83PINK10.69662741
84PRKCH0.68855036
85NEK10.68685097
86CDK140.68194772
87PTK2B0.68176628
88FES0.67001077
89RPS6KA20.66491484
90SGK30.65848451
91MAP3K10.64428709
92RPS6KB20.58867086
93TNIK0.58532013
94ERBB20.55105005
95DYRK20.54512537
96PRKD30.54497710
97RPS6KA50.53694801
98CDK180.52802665
99PRKG20.51661083
100EGFR0.51610893
101MKNK20.49966161
102MAPK100.49927026
103PAK10.49609908
104PRKCB0.47515738
105RAF10.47263907
106GRK60.47137463
107STK390.46281536
108BRSK10.46213056
109PIK3CA0.45017577
110PRKCQ0.44908238
111CDC42BPA0.44763132
112CDK150.44373375
113BRAF0.44124020
114CAMK2B0.43398834
115BRSK20.42764533
116SRC0.41903900
117CAMK2G0.41591962
118SGK10.41487321
119TLK10.40729748
120RPS6KC10.39780447
121RPS6KL10.39780447
122MAP3K20.39492687
123CHEK20.39231891
124SRPK10.39144995
125PIM20.38996053
126DAPK30.37585809
127ATM0.37139006
128ROCK20.35918392
129PRKD10.35880977
130MAP2K60.34740714
131FGR0.34671279
132PRKACA0.34243510
133PRKACG0.33921888
134FYN0.33878830
135CAMK2D0.33802031
136CSNK1G20.33727746
137SCYL20.33255144
138DYRK1A0.32600034
139PLK10.31796504
140RPS6KA30.31391027
141WNK10.31249602
142SYK0.31211126
143PRKCA0.30759860
144CDK11A0.30368624
145MAPK80.29382104
146CSNK1E0.27384562
147NUAK10.25504061
148PDK20.24952053
149RPS6KA10.23347532
150BTK0.23313896
151CDK40.22840724
152OXSR10.22692868
153PRKG10.21668872
154AURKA0.21638340
155CSNK1A10.19654161
156TSSK60.18914982
157PRKACB0.14923001
158SIK10.14797870

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006047.98909797
2Sulfur relay system_Homo sapiens_hsa041224.28216149
3Synaptic vesicle cycle_Homo sapiens_hsa047213.98952333
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.49682265
5Nicotine addiction_Homo sapiens_hsa050333.24938634
6Collecting duct acid secretion_Homo sapiens_hsa049662.63019120
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.59893981
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.51261478
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.43376896
10Taste transduction_Homo sapiens_hsa047422.42507715
11Nitrogen metabolism_Homo sapiens_hsa009102.40857219
12GABAergic synapse_Homo sapiens_hsa047272.31234041
13Circadian entrainment_Homo sapiens_hsa047132.21078169
14Olfactory transduction_Homo sapiens_hsa047402.20595717
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.19887135
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.15558001
17Long-term potentiation_Homo sapiens_hsa047202.11590666
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10115484
19Morphine addiction_Homo sapiens_hsa050321.98738749
20Glutamatergic synapse_Homo sapiens_hsa047241.93863344
21Dopaminergic synapse_Homo sapiens_hsa047281.86793907
22Vibrio cholerae infection_Homo sapiens_hsa051101.85157701
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.78785067
24Salivary secretion_Homo sapiens_hsa049701.78475471
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.72950031
26Long-term depression_Homo sapiens_hsa047301.67993449
27Calcium signaling pathway_Homo sapiens_hsa040201.66941910
28Sulfur metabolism_Homo sapiens_hsa009201.60802589
29Amphetamine addiction_Homo sapiens_hsa050311.59893991
30Cholinergic synapse_Homo sapiens_hsa047251.57222470
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.52536905
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50544888
33Hippo signaling pathway_Homo sapiens_hsa043901.48435635
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48270657
35Renin secretion_Homo sapiens_hsa049241.45569242
36Serotonergic synapse_Homo sapiens_hsa047261.44367070
37Gap junction_Homo sapiens_hsa045401.42424207
38Insulin secretion_Homo sapiens_hsa049111.40731015
39Base excision repair_Homo sapiens_hsa034101.39325569
40Arginine biosynthesis_Homo sapiens_hsa002201.39171776
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38162940
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37596397
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.35346029
44Selenocompound metabolism_Homo sapiens_hsa004501.29160513
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28694089
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26618176
47Gastric acid secretion_Homo sapiens_hsa049711.26149098
48Steroid biosynthesis_Homo sapiens_hsa001001.25569947
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24622484
50Phagosome_Homo sapiens_hsa041451.23818263
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.19902562
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17202612
53Butanoate metabolism_Homo sapiens_hsa006501.16112777
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14263986
55Oxytocin signaling pathway_Homo sapiens_hsa049211.13008624
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12296823
57Fanconi anemia pathway_Homo sapiens_hsa034601.11111909
58Fructose and mannose metabolism_Homo sapiens_hsa000511.10729690
59Hedgehog signaling pathway_Homo sapiens_hsa043401.08395071
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07076745
61Type II diabetes mellitus_Homo sapiens_hsa049301.05149296
62GnRH signaling pathway_Homo sapiens_hsa049121.03679058
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00927305
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00814817
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00448321
66Type I diabetes mellitus_Homo sapiens_hsa049400.97925382
67Alcoholism_Homo sapiens_hsa050340.95065064
68Circadian rhythm_Homo sapiens_hsa047100.94049545
69Glioma_Homo sapiens_hsa052140.93312411
70Folate biosynthesis_Homo sapiens_hsa007900.92051164
71cAMP signaling pathway_Homo sapiens_hsa040240.91669033
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91582738
73Cocaine addiction_Homo sapiens_hsa050300.91352654
74Oocyte meiosis_Homo sapiens_hsa041140.90305171
75Axon guidance_Homo sapiens_hsa043600.88216427
76ErbB signaling pathway_Homo sapiens_hsa040120.87777931
77mRNA surveillance pathway_Homo sapiens_hsa030150.86507270
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84462845
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82723864
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82230279
81Cardiac muscle contraction_Homo sapiens_hsa042600.82163898
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81790938
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75538296
84Estrogen signaling pathway_Homo sapiens_hsa049150.73506744
85Insulin signaling pathway_Homo sapiens_hsa049100.70624070
86TGF-beta signaling pathway_Homo sapiens_hsa043500.68707890
87Rheumatoid arthritis_Homo sapiens_hsa053230.68016831
88Melanogenesis_Homo sapiens_hsa049160.65739920
89Protein export_Homo sapiens_hsa030600.65184312
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.64387147
91Oxidative phosphorylation_Homo sapiens_hsa001900.63886397
92Ether lipid metabolism_Homo sapiens_hsa005650.63866237
93Histidine metabolism_Homo sapiens_hsa003400.62503680
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.62131540
95Biosynthesis of amino acids_Homo sapiens_hsa012300.61465497
96Choline metabolism in cancer_Homo sapiens_hsa052310.61457669
97beta-Alanine metabolism_Homo sapiens_hsa004100.61156693
98Dilated cardiomyopathy_Homo sapiens_hsa054140.61092467
99Endometrial cancer_Homo sapiens_hsa052130.58472840
100RNA polymerase_Homo sapiens_hsa030200.58442346
101Fatty acid elongation_Homo sapiens_hsa000620.55624350
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.55057130
103Alzheimers disease_Homo sapiens_hsa050100.54840180
104Basal transcription factors_Homo sapiens_hsa030220.54804907
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.54600126
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53674128
107MAPK signaling pathway_Homo sapiens_hsa040100.53631796
108Glucagon signaling pathway_Homo sapiens_hsa049220.53466370
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.52913836
110Bile secretion_Homo sapiens_hsa049760.50947014
111Sphingolipid metabolism_Homo sapiens_hsa006000.50101002
112Ras signaling pathway_Homo sapiens_hsa040140.50075247
113ABC transporters_Homo sapiens_hsa020100.48891712
114VEGF signaling pathway_Homo sapiens_hsa043700.48604517
115Chemical carcinogenesis_Homo sapiens_hsa052040.48313890
116Pyruvate metabolism_Homo sapiens_hsa006200.48287229
117Basal cell carcinoma_Homo sapiens_hsa052170.48241307
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46446371
119Dorso-ventral axis formation_Homo sapiens_hsa043200.45578288
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.45513667
121Inositol phosphate metabolism_Homo sapiens_hsa005620.45120132
122Systemic lupus erythematosus_Homo sapiens_hsa053220.45080612
123AMPK signaling pathway_Homo sapiens_hsa041520.44419001
124Purine metabolism_Homo sapiens_hsa002300.43463161
125Pyrimidine metabolism_Homo sapiens_hsa002400.43460979
126Phototransduction_Homo sapiens_hsa047440.42229323
127Endocytosis_Homo sapiens_hsa041440.42143345
128Cell cycle_Homo sapiens_hsa041100.41727940
129Metabolic pathways_Homo sapiens_hsa011000.41672757
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41459911
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41427577
132Peroxisome_Homo sapiens_hsa041460.40066575
133Parkinsons disease_Homo sapiens_hsa050120.39037129
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38996159
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.38833493
136Thyroid hormone synthesis_Homo sapiens_hsa049180.38752153
1372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37771325
138p53 signaling pathway_Homo sapiens_hsa041150.37516758
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.36874217
140Adipocytokine signaling pathway_Homo sapiens_hsa049200.36329030
141Rap1 signaling pathway_Homo sapiens_hsa040150.35916710
142Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35543503
143Salmonella infection_Homo sapiens_hsa051320.35524771
144Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35472285
145Glycerolipid metabolism_Homo sapiens_hsa005610.35414992
146Tight junction_Homo sapiens_hsa045300.33527720
147Glycerophospholipid metabolism_Homo sapiens_hsa005640.33029928
148Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30646317
149Fatty acid biosynthesis_Homo sapiens_hsa000610.30500558
150Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30482540
151Tryptophan metabolism_Homo sapiens_hsa003800.28499951
152Fatty acid metabolism_Homo sapiens_hsa012120.28445756
153Caffeine metabolism_Homo sapiens_hsa002320.27226248
154Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27123558
155Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26792306
156Melanoma_Homo sapiens_hsa052180.26287470
157Shigellosis_Homo sapiens_hsa051310.23999327
158Cysteine and methionine metabolism_Homo sapiens_hsa002700.22728871
159Thyroid cancer_Homo sapiens_hsa052160.22101981
160Intestinal immune network for IgA production_Homo sapiens_hsa046720.22041848
161Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21288925

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