GPR152

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of guanylate cyclase activity (GO:0031282)9.26225118
2protein-chromophore linkage (GO:0018298)8.91149611
3visual perception (GO:0007601)8.67551220
4retinal rod cell development (GO:0046548)8.65670311
5sensory perception of light stimulus (GO:0050953)8.57501617
6cellular response to light stimulus (GO:0071482)8.13265734
7eye photoreceptor cell differentiation (GO:0001754)7.28857303
8photoreceptor cell differentiation (GO:0046530)7.28857303
9detection of external stimulus (GO:0009581)6.97936254
10detection of abiotic stimulus (GO:0009582)6.83278872
11retina development in camera-type eye (GO:0060041)6.56965547
12regulation of cGMP metabolic process (GO:0030823)6.39288038
13receptor guanylyl cyclase signaling pathway (GO:0007168)6.33021972
14positive regulation of cGMP biosynthetic process (GO:0030828)5.91558629
15regulation of cGMP biosynthetic process (GO:0030826)5.54239683
16adaptation of signaling pathway (GO:0023058)5.34540508
17cellular response to radiation (GO:0071478)5.26348173
18nonmotile primary cilium assembly (GO:0035058)5.23395966
19positive regulation of cGMP metabolic process (GO:0030825)5.18362596
20cell morphogenesis involved in neuron differentiation (GO:0048667)5.13791195
21regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.76715012
22regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.66858447
23positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.30505843
24sensory perception (GO:0007600)4.02741556
25detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.96197550
26regulation of voltage-gated calcium channel activity (GO:1901385)3.93355910
27response to light stimulus (GO:0009416)3.86946417
28negative regulation of receptor-mediated endocytosis (GO:0048261)3.79467594
29prenylation (GO:0097354)3.71929011
30protein prenylation (GO:0018342)3.71929011
31protein localization to synapse (GO:0035418)3.70121963
32CDP-diacylglycerol biosynthetic process (GO:0016024)3.65401316
33regulation of clathrin-mediated endocytosis (GO:2000369)3.64967327
34retina layer formation (GO:0010842)3.60042506
35neuron development (GO:0048666)3.44035373
36CDP-diacylglycerol metabolic process (GO:0046341)3.30891164
37retina homeostasis (GO:0001895)3.28703385
38short-term memory (GO:0007614)3.20342441
39behavioral response to ethanol (GO:0048149)3.19640359
40positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.07049576
41estrogen biosynthetic process (GO:0006703)3.02194311
42regulation of penile erection (GO:0060405)3.00996381
43chemosensory behavior (GO:0007635)2.92987486
44regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.90508920
45regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.90508920
46positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.84464206
47negative regulation of transcription regulatory region DNA binding (GO:2000678)2.81531297
48positive regulation of neurotransmitter transport (GO:0051590)2.80217752
49positive regulation of sodium ion transmembrane transport (GO:1902307)2.79879478
50response to histamine (GO:0034776)2.78086896
51regulation of short-term neuronal synaptic plasticity (GO:0048172)2.78068379
52phospholipid translocation (GO:0045332)2.76656802
53lipid translocation (GO:0034204)2.76656802
54retinoid metabolic process (GO:0001523)2.74161988
55negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.73215653
56cellular response to abiotic stimulus (GO:0071214)2.70431815
57positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.70261489
58axoneme assembly (GO:0035082)2.69198179
59membrane hyperpolarization (GO:0060081)2.68291509
60arachidonic acid secretion (GO:0050482)2.68178967
61icosanoid secretion (GO:0032309)2.68178967
62positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.65028088
63response to radiation (GO:0009314)2.64928088
64establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.64403995
65mitochondrion transport along microtubule (GO:0047497)2.64403995
66post-embryonic morphogenesis (GO:0009886)2.64305337
67diterpenoid metabolic process (GO:0016101)2.52821766
68dopamine receptor signaling pathway (GO:0007212)2.49663890
69retinol metabolic process (GO:0042572)2.49018767
70positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.48980010
71negative regulation of cation channel activity (GO:2001258)2.45702532
72synaptic vesicle maturation (GO:0016188)2.45355459
73lipoprotein transport (GO:0042953)2.45152739
74negative regulation of calcium ion transmembrane transport (GO:1903170)2.40289509
75negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.40289509
76behavioral response to cocaine (GO:0048148)2.40234596
77establishment of mitochondrion localization (GO:0051654)2.39321211
78synaptic transmission, dopaminergic (GO:0001963)2.38431135
79fatty acid elongation (GO:0030497)2.37689995
80positive regulation of cyclase activity (GO:0031281)2.36733476
81peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.33952294
82negative regulation of mast cell activation (GO:0033004)2.32512843
83positive regulation of ERBB signaling pathway (GO:1901186)2.30960606
84terpenoid metabolic process (GO:0006721)2.30659805
85lactate metabolic process (GO:0006089)2.28675467
86sodium ion export (GO:0071436)2.24815515
87regulation of rhodopsin mediated signaling pathway (GO:0022400)19.8762423
88rhodopsin mediated signaling pathway (GO:0016056)19.4792832
89retinal cone cell development (GO:0046549)13.9332741
90photoreceptor cell maintenance (GO:0045494)12.5581955
91photoreceptor cell development (GO:0042461)12.0524337
92eye photoreceptor cell development (GO:0042462)11.4791115
93GMP metabolic process (GO:0046037)11.0030461
94phototransduction, visible light (GO:0007603)10.7645191
95detection of light stimulus involved in sensory perception (GO:0050962)10.7246885
96detection of light stimulus involved in visual perception (GO:0050908)10.7246885
97phototransduction (GO:0007602)10.6250497
98positive regulation of guanylate cyclase activity (GO:0031284)10.2686587
99detection of visible light (GO:0009584)10.2168454
100detection of light stimulus (GO:0009583)10.0635895

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.56925876
2CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse5.02508288
3DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.24858878
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.08486930
5GBX2_23144817_ChIP-Seq_PC3_Human2.47285639
6DROSHA_22980978_ChIP-Seq_HELA_Human2.26905482
7BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.16233663
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92811607
9SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90620142
10KDM2B_26808549_Chip-Seq_K562_Human1.85616771
11SMAD3_21741376_ChIP-Seq_HESCs_Human1.74677444
12RARB_27405468_Chip-Seq_BRAIN_Mouse1.73118569
13AR_21572438_ChIP-Seq_LNCaP_Human1.72743155
14IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68829398
15VDR_22108803_ChIP-Seq_LS180_Human1.67501345
16REST_18959480_ChIP-ChIP_MESCs_Mouse1.63765791
17ELK4_26923725_Chip-Seq_MESODERM_Mouse1.61635907
18GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.61035359
19TCF4_18268006_ChIP-ChIP_LS174T_Human1.60088346
20AR_19668381_ChIP-Seq_PC3_Human1.56715436
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56612177
22RUNX_20019798_ChIP-Seq_JUKART_Human1.52633595
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50647272
24SMC4_20622854_ChIP-Seq_HELA_Human1.49942221
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49418469
26GATA1_19941827_ChIP-Seq_MEL_Mouse1.45922414
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41832185
28TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.41702473
29NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.37693403
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.37006896
31VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.35746986
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35231196
33MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34507627
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.32617938
35P53_22127205_ChIP-Seq_FIBROBLAST_Human1.30829113
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30142233
37CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30026990
38CREB1_26743006_Chip-Seq_LNCaP_Human1.29096043
39REST_21632747_ChIP-Seq_MESCs_Mouse1.25890295
40SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25504410
41RING1B_27294783_Chip-Seq_NPCs_Mouse1.25464731
42TAF2_19829295_ChIP-Seq_ESCs_Human1.23850167
43KDM2B_26808549_Chip-Seq_JURKAT_Human1.22876377
44P68_20966046_ChIP-Seq_HELA_Human1.22513417
45TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22202621
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21872276
47* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.21216698
48TBL1_22424771_ChIP-Seq_293T_Human1.21140818
49CTCF_20526341_ChIP-Seq_ESCs_Human1.20052025
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13420197
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13300099
52WDR5_24793694_ChIP-Seq_LNCAP_Human1.13178276
53NCOR_22424771_ChIP-Seq_293T_Human1.12562816
54SMAD4_21799915_ChIP-Seq_A2780_Human1.12314257
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12201264
56LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10621822
57EGR1_19032775_ChIP-ChIP_M12_Human1.09968440
58CTCF_27219007_Chip-Seq_Bcells_Human1.09687459
59CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09580088
60OCT1_27270436_Chip-Seq_PROSTATE_Human1.09518663
61STAT3_23295773_ChIP-Seq_U87_Human1.07408512
62SMAD4_21741376_ChIP-Seq_ESCs_Human1.07334249
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07333497
64FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.06018431
65PRDM14_20953172_ChIP-Seq_ESCs_Human1.05429891
66CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05095260
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04010440
68CBP_21632823_ChIP-Seq_H3396_Human1.03509725
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01989246
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01273882
71SCL_19346495_ChIP-Seq_HPC-7_Human1.01024229
72LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00716636
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99967804
74LXR_22292898_ChIP-Seq_THP-1_Human0.99571848
75SMAD4_21741376_ChIP-Seq_HESCs_Human0.99431067
76EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99351557
77DPY_21335234_ChIP-Seq_ESCs_Mouse0.98703446
78IGF1R_20145208_ChIP-Seq_DFB_Human0.98639887
79KDM2B_26808549_Chip-Seq_DND41_Human0.97810777
80BCAT_22108803_ChIP-Seq_LS180_Human0.97432523
81* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.96899015
82ISL1_27105846_Chip-Seq_CPCs_Mouse0.96185261
83SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96135613
84AHR_22903824_ChIP-Seq_MCF-7_Human0.93838408
85SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93829358
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92463801
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89585627
88GF1_26923725_Chip-Seq_HPCs_Mouse0.89421408
89RNF2_27304074_Chip-Seq_ESCs_Mouse0.88616556
90TP53_23651856_ChIP-Seq_MEFs_Mouse0.88516957
91PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87845574
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86639192
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86133190
94OCT4_19829295_ChIP-Seq_ESCs_Human0.85704419
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85631448
96FOXA2_19822575_ChIP-Seq_HepG2_Human0.85572583
97EZH2_18974828_ChIP-Seq_MESCs_Mouse0.85210581
98RNF2_18974828_ChIP-Seq_MESCs_Mouse0.85210581
99NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84943478
100DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84018027

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005253_abnormal_eye_physiology6.91920443
2MP0006072_abnormal_retinal_apoptosis6.37053908
3MP0003950_abnormal_plasma_membrane4.89855202
4MP0005195_abnormal_posterior_eye3.94105016
5MP0002638_abnormal_pupillary_reflex3.70883455
6MP0001324_abnormal_eye_pigmentation3.55423553
7MP0005391_vision/eye_phenotype3.32752795
8MP0002090_abnormal_vision2.91212011
9MP0002229_neurodegeneration2.61910427
10MP0001764_abnormal_homeostasis2.56227482
11MP0005423_abnormal_somatic_nervous2.32735218
12MP0003011_delayed_dark_adaptation10.5587435
13MP0005551_abnormal_eye_electrophysiolog10.1042047
14MP0002752_abnormal_somatic_nervous1.89435577
15MP0001986_abnormal_taste_sensitivity1.74011804
16MP0004233_abnormal_muscle_weight1.47023117
17MP0002882_abnormal_neuron_morphology1.36721143
18MP0004019_abnormal_vitamin_homeostasis1.30967594
19MP0002653_abnormal_ependyma_morphology1.14401931
20MP0001984_abnormal_olfaction1.03220071
21MP0001502_abnormal_circadian_rhythm1.02446763
22MP0004885_abnormal_endolymph0.94054587
23MP0005197_abnormal_uvea_morphology0.93618372
24MP0005187_abnormal_penis_morphology0.87997956
25MP0003634_abnormal_glial_cell0.87583449
26MP0004270_analgesia0.75894869
27MP0009780_abnormal_chondrocyte_physiolo0.74487467
28MP0002332_abnormal_exercise_endurance0.70343947
29MP0001486_abnormal_startle_reflex0.70318677
30MP0002272_abnormal_nervous_system0.62135135
31MP0005376_homeostasis/metabolism_phenot0.60149574
32MP0001963_abnormal_hearing_physiology0.58401253
33MP0002127_abnormal_cardiovascular_syste0.58134374
34MP0009046_muscle_twitch0.52139514
35MP0004859_abnormal_synaptic_plasticity0.51097135
36MP0000465_gastrointestinal_hemorrhage0.49618353
37MP0001286_abnormal_eye_development0.48727703
38MP0005394_taste/olfaction_phenotype0.48278208
39MP0005499_abnormal_olfactory_system0.48278208
40MP0005076_abnormal_cell_differentiation0.46807395
41MP0002064_seizures0.46527109
42MP0003045_fibrosis0.41400392
43MP0002734_abnormal_mechanical_nocicepti0.39868782
44MP0002067_abnormal_sensory_capabilities0.37734449
45MP0003880_abnormal_central_pattern0.36960903
46MP0002928_abnormal_bile_duct0.34952985
47MP0001661_extended_life_span0.34005496
48MP0003635_abnormal_synaptic_transmissio0.33422297
49MP0005386_behavior/neurological_phenoty0.33031094
50MP0004924_abnormal_behavior0.33031094
51MP0000026_abnormal_inner_ear0.32991199
52MP0002572_abnormal_emotion/affect_behav0.31394899
53MP0001968_abnormal_touch/_nociception0.31098975
54MP0008789_abnormal_olfactory_epithelium0.30352049
55MP0002063_abnormal_learning/memory/cond0.29107227
56MP0006292_abnormal_olfactory_placode0.27523454
57MP0008569_lethality_at_weaning0.27508845
58MP0003252_abnormal_bile_duct0.27026136
59MP0003646_muscle_fatigue0.26754423
60MP0004085_abnormal_heartbeat0.26081824
61MP0005330_cardiomyopathy0.24788802
62MP0008961_abnormal_basal_metabolism0.24058159
63MP0003632_abnormal_nervous_system0.22802837
64MP0004215_abnormal_myocardial_fiber0.22281541
65MP0005620_abnormal_muscle_contractility0.22230596
66MP0001915_intracranial_hemorrhage0.21133167
67MP0001501_abnormal_sleep_pattern0.19987157
68MP0002066_abnormal_motor_capabilities/c0.19837538
69MP0002971_abnormal_brown_adipose0.19092002
70MP0008004_abnormal_stomach_pH0.18741922
71MP0009745_abnormal_behavioral_response0.17947424
72MP0004782_abnormal_surfactant_physiolog0.17934211
73MP0001905_abnormal_dopamine_level0.17767736
74MP0003943_abnormal_hepatobiliary_system0.16187753
75MP0005360_urolithiasis0.15994739
76MP0004043_abnormal_pH_regulation0.15657468
77MP0004142_abnormal_muscle_tone0.14188166
78MP0002152_abnormal_brain_morphology0.13573342
79MP0002108_abnormal_muscle_morphology0.11806097
80MP0005334_abnormal_fat_pad0.11224885
81MP0000631_abnormal_neuroendocrine_gland0.11171797
82MP0001879_abnormal_lymphatic_vessel0.10514519
83MP0004742_abnormal_vestibular_system0.09488318
84MP0005310_abnormal_salivary_gland0.09428233
85MP0003631_nervous_system_phenotype0.09394872
86MP0003638_abnormal_response/metabolism_0.09138953
87MP0001614_abnormal_blood_vessel0.08979823
88MP0002078_abnormal_glucose_homeostasis0.08783473
89MP0003890_abnormal_embryonic-extraembry0.08771845
90MP0004036_abnormal_muscle_relaxation0.08557734
91MP0004811_abnormal_neuron_physiology0.08419181
92MP0000001_mammalian_phenotype0.08279287
93MP0004130_abnormal_muscle_cell0.08273384
94MP0005193_abnormal_anterior_eye0.07916172
95MP0001727_abnormal_embryo_implantation0.07849218
96MP0003633_abnormal_nervous_system0.07518488
97MP0003956_abnormal_body_size0.07368439
98MP0005266_abnormal_metabolism0.07157171
99MP0010329_abnormal_lipoprotein_level0.07102290
100MP0000647_abnormal_sebaceous_gland0.06899048

Predicted human phenotypes

RankGene SetZ-score
1Chorioretinal atrophy (HP:0000533)9.89717667
2Absent rod-and cone-mediated responses on ERG (HP:0007688)9.49550006
3Pigmentary retinal degeneration (HP:0001146)9.15466800
4Attenuation of retinal blood vessels (HP:0007843)8.34831713
5Central scotoma (HP:0000603)8.16547318
6Scotoma (HP:0000575)7.62042918
7Pendular nystagmus (HP:0012043)7.53356799
8Abnormality of macular pigmentation (HP:0008002)7.36202229
9Dyschromatopsia (HP:0007641)7.16516693
10Abolished electroretinogram (ERG) (HP:0000550)6.31234901
11Decreased central vision (HP:0007663)5.97187550
12Type II diabetes mellitus (HP:0005978)5.94424156
13Photophobia (HP:0000613)5.78172689
14Cone-rod dystrophy (HP:0000548)5.65637672
15Increased corneal curvature (HP:0100692)5.28052706
16Keratoconus (HP:0000563)5.28052706
17Retinitis pigmentosa (HP:0000510)4.92955570
18Vitreoretinal degeneration (HP:0000655)4.75152620
19Choroideremia (HP:0001139)4.63821614
20Macular degeneration (HP:0000608)4.54684874
21Constricted visual fields (HP:0001133)4.41806681
22Posterior subcapsular cataract (HP:0007787)3.99608657
23Severe visual impairment (HP:0001141)3.88402453
24Decreased electroretinogram (ERG) amplitude (HP:0000654)3.82679511
25Retinal atrophy (HP:0001105)3.06639492
26Progressive visual loss (HP:0000529)3.04396079
27Optic disc pallor (HP:0000543)2.74254601
28Congenital sensorineural hearing impairment (HP:0008527)2.71677190
29Gait imbalance (HP:0002141)2.70236982
30Congenital primary aphakia (HP:0007707)2.67987166
31Wide nasal bridge (HP:0000431)2.63181064
32Subcapsular cataract (HP:0000523)2.43219392
33Nephrogenic diabetes insipidus (HP:0009806)2.37376639
34Medial flaring of the eyebrow (HP:0010747)2.27812459
35Poor coordination (HP:0002370)2.03306187
36Congenital stationary night blindness (HP:0007642)14.8030733
37Bony spicule pigmentary retinopathy (HP:0007737)13.1254047
38Abnormal rod and cone electroretinograms (HP:0008323)10.0760081
39Vaginal atresia (HP:0000148)1.87571214
40Genital tract atresia (HP:0001827)1.78666828
41Optic atrophy (HP:0000648)1.71424158
42Interstitial pulmonary disease (HP:0006530)1.68067561
43Horizontal nystagmus (HP:0000666)1.55684543
44Aplasia/Hypoplasia of the lens (HP:0008063)1.49341559
45Dysdiadochokinesis (HP:0002075)1.42642072
46Severe Myopia (HP:0011003)1.33497393
47Polar cataract (HP:0010696)1.30004283
48Astigmatism (HP:0000483)1.28107054
49Retinal detachment (HP:0000541)1.22763255
50Recurrent sinusitis (HP:0011108)1.18889235
51Cerebellar dysplasia (HP:0007033)1.18442480
52True hermaphroditism (HP:0010459)1.12785096
53Pancreatic fibrosis (HP:0100732)1.12183185
54Specific learning disability (HP:0001328)1.09884702
55Broad foot (HP:0001769)1.08599893
56Epileptic encephalopathy (HP:0200134)1.06705029
57Left ventricular hypertrophy (HP:0001712)1.05066753
58Asthma (HP:0002099)1.04716725
59Decreased testicular size (HP:0008734)1.00512063
60Abnormality of the fovea (HP:0000493)1.00295853
61Truncal ataxia (HP:0002078)0.98869919
62Cystic liver disease (HP:0006706)0.96886295
63Progressive cerebellar ataxia (HP:0002073)0.95716443
64Pancreatic cysts (HP:0001737)0.93361303
65Aplasia/Hypoplasia of the fovea (HP:0008060)0.91528582
66Hypoplasia of the fovea (HP:0007750)0.91528582
67Partial agenesis of the corpus callosum (HP:0001338)0.90202686
68Abnormality of dental color (HP:0011073)0.88712538
69Hypermetropia (HP:0000540)0.85638597
70Chorioretinal coloboma (HP:0000567)0.85586866
71Abnormality of midbrain morphology (HP:0002418)0.85077912
72Molar tooth sign on MRI (HP:0002419)0.85077912
73Lymphopenia (HP:0001888)0.84765811
74Febrile seizures (HP:0002373)0.83688944
75Furrowed tongue (HP:0000221)0.80199563
76Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.79879953
77Dental crowding (HP:0000678)0.78870670
78Abnormality of cells of the lymphoid lineage (HP:0012140)0.78453425
79Aplasia/Hypoplasia of the tongue (HP:0010295)0.77615929
80Chronic hepatic failure (HP:0100626)0.76792722
81Abnormality of the fingertips (HP:0001211)0.76156347
82Macroorchidism (HP:0000053)0.74397342
83Short foot (HP:0001773)0.74380411
84Vertebral arch anomaly (HP:0008438)0.71983424
85Gastrointestinal stroma tumor (HP:0100723)0.71290010
86Visual hallucinations (HP:0002367)0.69701073
87Hypodontia (HP:0000668)0.69596264
88Prolonged QT interval (HP:0001657)0.67718749
89Generalized myoclonic seizures (HP:0002123)0.67474945
90Hirsutism (HP:0001007)0.66449508
91Heterotopia (HP:0002282)0.65545154
92Sclerocornea (HP:0000647)0.64917863
93Nephrotic syndrome (HP:0000100)0.64916962
94Aplasia/Hypoplasia of the macula (HP:0008059)0.64884433
95Urinary bladder sphincter dysfunction (HP:0002839)0.62868800
96Postaxial hand polydactyly (HP:0001162)0.62802272
97Genetic anticipation (HP:0003743)0.59988386
98Nephronophthisis (HP:0000090)0.59777456
99Aqueductal stenosis (HP:0002410)0.59385588
100Prominent nasal bridge (HP:0000426)0.58919854

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK8.41135206
2PINK12.87322773
3IRAK22.85517734
4SIK22.19332570
5GRK110.3579561
6MAP3K101.89825012
7CDK121.79376404
8MAPK121.78264122
9BRD41.66358389
10TAOK31.55263382
11MAPK71.37844612
12CAMK1G1.35554173
13PAK61.30311320
14ADRBK11.28692389
15FRK1.20483248
16MAP3K41.13151221
17PRKCH1.04009038
18HIPK21.01586402
19CSNK1D1.01333687
20CAMK1D0.99422657
21PRKD30.96696506
22PNCK0.92955091
23RPS6KA40.91659664
24PRKCZ0.88119351
25ICK0.84783423
26STK380.83049678
27DYRK1A0.81983957
28PRKAA20.79682871
29PRKAA10.79340006
30WNK10.77595243
31NEK20.75790871
32FES0.75088262
33SGK2230.74962548
34SGK4940.74962548
35SGK30.73253008
36SIK10.70303436
37SGK20.69682723
38INSRR0.65000552
39PHKG20.64460495
40PHKG10.64460495
41PRKCB0.64212113
42FGFR20.63857814
43CAMKK10.63252657
44TTK0.62803068
45PRKD20.60826462
46PRKACG0.60599279
47PAK30.60405994
48MAP3K70.59803283
49PKN10.57454668
50DYRK1B0.57051774
51CAMK2D0.57030736
52MARK10.56201712
53PDK20.55870011
54RPS6KA30.55499103
55MARK20.53534449
56NEK60.51965235
57STK110.49653592
58CAMK10.45421765
59AKT20.44773827
60AKT30.43965347
61TNK20.42723303
62MAPK90.41451372
63MKNK20.41392805
64GSK3B0.41081202
65PRKDC0.40058791
66ALK0.39861065
67MAPK140.39352957
68ERBB20.38823841
69CDK50.36770660
70ERN10.36225530
71SGK10.35679326
72PDK10.34236624
73EEF2K0.32552369
74CDK90.32332283
75CHUK0.31627549
76MAP2K40.31412540
77GRK50.30714794
78CDK10.30120379
79RPS6KB10.29151144
80PLK30.27284078
81MAPK30.27207031
82JAK10.27177837
83MAPK100.26254709
84CAMK40.26054155
85MAP3K130.25928629
86PRKACA0.25752594
87PRKCG0.25201894
88STK390.22416774
89MAPK80.22039995
90CSNK1E0.21268412
91CHEK10.21036527
92SCYL20.20803149
93SRC0.20311397
94MAPK40.19926296
95FGFR30.19706597
96PRKCA0.19322656
97CAMK2A0.18899269
98WNK40.18031455
99MAPK10.16919497
100MAP2K70.16555556

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa0474416.1468888
2Olfactory transduction_Homo sapiens_hsa047401.53132913
3Synaptic vesicle cycle_Homo sapiens_hsa047211.31739882
4GABAergic synapse_Homo sapiens_hsa047271.09150905
5Circadian rhythm_Homo sapiens_hsa047100.86683601
6Cholinergic synapse_Homo sapiens_hsa047250.84842432
7Morphine addiction_Homo sapiens_hsa050320.82287380
8Retinol metabolism_Homo sapiens_hsa008300.79617194
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79332646
10Dopaminergic synapse_Homo sapiens_hsa047280.74126030
11Circadian entrainment_Homo sapiens_hsa047130.70498853
12Glutamatergic synapse_Homo sapiens_hsa047240.69348943
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68129987
14ABC transporters_Homo sapiens_hsa020100.64448295
15Serotonergic synapse_Homo sapiens_hsa047260.63475196
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63470544
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62337212
18Nitrogen metabolism_Homo sapiens_hsa009100.49247394
19Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46471453
20cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45331829
21Fatty acid elongation_Homo sapiens_hsa000620.44011778
22Glycerolipid metabolism_Homo sapiens_hsa005610.43977290
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43818613
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40175156
25Insulin secretion_Homo sapiens_hsa049110.39131436
26Fructose and mannose metabolism_Homo sapiens_hsa000510.38040715
27Oxytocin signaling pathway_Homo sapiens_hsa049210.37542111
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37227252
29Purine metabolism_Homo sapiens_hsa002300.37044771
30Inositol phosphate metabolism_Homo sapiens_hsa005620.32282823
31Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31396560
32Caffeine metabolism_Homo sapiens_hsa002320.30042134
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28613706
34Nicotine addiction_Homo sapiens_hsa050330.28107425
35Glycerophospholipid metabolism_Homo sapiens_hsa005640.26802626
36Drug metabolism - other enzymes_Homo sapiens_hsa009830.26548415
37Arginine biosynthesis_Homo sapiens_hsa002200.25931964
38Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25468994
39Lysine degradation_Homo sapiens_hsa003100.24824967
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24719053
41cAMP signaling pathway_Homo sapiens_hsa040240.24706050
42Renin secretion_Homo sapiens_hsa049240.24268970
43Chemokine signaling pathway_Homo sapiens_hsa040620.23792338
44Alcoholism_Homo sapiens_hsa050340.23318488
45Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23159362
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22861122
47Glucagon signaling pathway_Homo sapiens_hsa049220.22343475
48Dilated cardiomyopathy_Homo sapiens_hsa054140.22296728
49mTOR signaling pathway_Homo sapiens_hsa041500.21606722
50Cocaine addiction_Homo sapiens_hsa050300.21513223
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.20800971
52Salivary secretion_Homo sapiens_hsa049700.19740009
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.19365528
54Long-term potentiation_Homo sapiens_hsa047200.18546438
55Gastric acid secretion_Homo sapiens_hsa049710.18427885
56Cardiac muscle contraction_Homo sapiens_hsa042600.18049323
57Type II diabetes mellitus_Homo sapiens_hsa049300.17751764
58HIF-1 signaling pathway_Homo sapiens_hsa040660.17610865
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15831053
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.15638511
61Biosynthesis of amino acids_Homo sapiens_hsa012300.15612570
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.15471143
63AMPK signaling pathway_Homo sapiens_hsa041520.15173154
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.14453601
65Ras signaling pathway_Homo sapiens_hsa040140.12778249
66Phenylalanine metabolism_Homo sapiens_hsa003600.10635155
67Insulin resistance_Homo sapiens_hsa049310.10548697
68Bile secretion_Homo sapiens_hsa049760.10387795
69Amphetamine addiction_Homo sapiens_hsa050310.08868276
70Galactose metabolism_Homo sapiens_hsa000520.08770849
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.08009534
72Calcium signaling pathway_Homo sapiens_hsa040200.07304719
73mRNA surveillance pathway_Homo sapiens_hsa030150.06762124
74Fatty acid biosynthesis_Homo sapiens_hsa000610.06670382
75GnRH signaling pathway_Homo sapiens_hsa049120.06425761
76Glioma_Homo sapiens_hsa052140.06064083
77Pancreatic secretion_Homo sapiens_hsa049720.06036608
78Fatty acid metabolism_Homo sapiens_hsa012120.05621915
79MAPK signaling pathway_Homo sapiens_hsa040100.05498342
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.05467701
81Tight junction_Homo sapiens_hsa045300.05309418
82Fat digestion and absorption_Homo sapiens_hsa049750.05293777
83Mineral absorption_Homo sapiens_hsa049780.05207483
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.04758389
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.04397206
86B cell receptor signaling pathway_Homo sapiens_hsa046620.04154289
87Renal cell carcinoma_Homo sapiens_hsa052110.04023846
88ErbB signaling pathway_Homo sapiens_hsa040120.02465913
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.02414493
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.02176027
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.01825679
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.01801909
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.01699458
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.01631633
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.01459778
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.00822243
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.00765277
98Pyruvate metabolism_Homo sapiens_hsa006200.00506223
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.00491045
100Thyroid hormone synthesis_Homo sapiens_hsa049180.00161139

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