GPR153

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutations in this gene are associated with schizophrenia, autism, and other neuropsychiatric disorders. The expression of this gene is activated by the glioma-associated oncogene homolog 1 transcription factor which, in turn, is activated by sonic hedgehog in normal and tumorigenic cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.05834098
2protein heterotrimerization (GO:0070208)5.06930753
3collagen fibril organization (GO:0030199)4.29035908
4bone trabecula formation (GO:0060346)4.23327789
5semaphorin-plexin signaling pathway (GO:0071526)4.17440168
6ganglion development (GO:0061548)4.13474027
7plasma membrane repair (GO:0001778)3.94556915
8pyrimidine nucleobase catabolic process (GO:0006208)3.86058126
9sequestering of extracellular ligand from receptor (GO:0035581)3.84535010
10negative regulation of axon extension involved in axon guidance (GO:0048843)3.83775582
11dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.76679042
12extracellular fibril organization (GO:0043206)3.61714285
13peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.55898121
14chondrocyte proliferation (GO:0035988)3.40518038
15protein retention in ER lumen (GO:0006621)3.36287917
16axon extension involved in axon guidance (GO:0048846)3.32052881
17neuron projection extension involved in neuron projection guidance (GO:1902284)3.32052881
18collagen metabolic process (GO:0032963)3.30947545
19facial nerve structural organization (GO:0021612)3.30328570
20collagen catabolic process (GO:0030574)3.26832050
21cell-cell junction maintenance (GO:0045217)3.25030052
22cardiac myofibril assembly (GO:0055003)3.23298273
23negative regulation of axon guidance (GO:1902668)3.22886082
24dermatan sulfate biosynthetic process (GO:0030208)3.20479372
25multicellular organismal macromolecule metabolic process (GO:0044259)3.16831845
26cranial nerve morphogenesis (GO:0021602)3.14510047
27nucleobase catabolic process (GO:0046113)3.11576274
28negative regulation of catenin import into nucleus (GO:0035414)3.11553765
29layer formation in cerebral cortex (GO:0021819)3.10314714
30cell communication by electrical coupling (GO:0010644)3.08022317
31synaptic vesicle maturation (GO:0016188)3.07873658
32vocalization behavior (GO:0071625)3.06964670
33skeletal muscle organ development (GO:0060538)3.05535032
34cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.04095880
35developmental cell growth (GO:0048588)3.02406113
36endodermal cell differentiation (GO:0035987)3.01457670
37establishment of mitochondrion localization (GO:0051654)2.99677518
38multicellular organismal catabolic process (GO:0044243)2.99513513
39locomotory exploration behavior (GO:0035641)2.99497860
40planar cell polarity pathway involved in neural tube closure (GO:0090179)2.98332361
41cell-substrate junction assembly (GO:0007044)2.97576648
42sodium ion export (GO:0071436)2.95938136
43maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.95877877
44multicellular organismal metabolic process (GO:0044236)2.95132110
45dopamine receptor signaling pathway (GO:0007212)2.90296887
46establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.88390135
47mitochondrion transport along microtubule (GO:0047497)2.88390135
48fibril organization (GO:0097435)2.86068801
49negative regulation of fatty acid transport (GO:2000192)2.85579183
50positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.85540606
51dermatan sulfate metabolic process (GO:0030205)2.85470941
52regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.84767837
53substrate-dependent cell migration (GO:0006929)2.83959306
54establishment of tissue polarity (GO:0007164)2.82162999
55establishment of planar polarity (GO:0001736)2.82162999
56positive regulation of pseudopodium assembly (GO:0031274)2.82083802
57regulation of establishment of planar polarity (GO:0090175)2.81251614
58cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.80587304
59regulation of short-term neuronal synaptic plasticity (GO:0048172)2.78806117
60extracellular matrix disassembly (GO:0022617)2.77411152
61postsynaptic membrane organization (GO:0001941)2.76985268
62ephrin receptor signaling pathway (GO:0048013)2.76721051
63regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.75641706
64cochlea morphogenesis (GO:0090103)2.74176452
65adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.73959538
66desmosome organization (GO:0002934)2.68708971
67regulation of pseudopodium assembly (GO:0031272)2.67583053
68dendritic spine morphogenesis (GO:0060997)2.67242002
69establishment of nucleus localization (GO:0040023)2.66825200
70neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.66288055
71craniofacial suture morphogenesis (GO:0097094)2.66268390
72substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.66249549
73substrate-independent telencephalic tangential migration (GO:0021826)2.66249549
74axon extension (GO:0048675)2.64125750
75camera-type eye morphogenesis (GO:0048593)2.63192053
76axonal fasciculation (GO:0007413)2.62925877
77convergent extension (GO:0060026)2.61963400
78regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.61854317
79skin morphogenesis (GO:0043589)2.61600455
80establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.61395087
81insulin-like growth factor receptor signaling pathway (GO:0048009)2.60160911
82cranial nerve structural organization (GO:0021604)2.59305795
83negative regulation of chondrocyte differentiation (GO:0032331)2.58619875
84positive regulation of gastrulation (GO:2000543)2.58394601
85cell junction maintenance (GO:0034331)2.58169803
86regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.56120454
87positive regulation of fibroblast migration (GO:0010763)2.55989844
88regulation of axon extension involved in axon guidance (GO:0048841)2.54883796
89diaphragm development (GO:0060539)2.54608053
90regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.53682972
91neuronal ion channel clustering (GO:0045161)2.53385044
92endothelial cell chemotaxis (GO:0035767)2.53255409
93cellular response to prostaglandin stimulus (GO:0071379)2.53082102
94endocardial cushion morphogenesis (GO:0003203)2.52817240
95activation of protein kinase A activity (GO:0034199)2.50890729
96cytoskeletal anchoring at plasma membrane (GO:0007016)2.49977453
97establishment or maintenance of monopolar cell polarity (GO:0061339)2.49936357
98establishment of monopolar cell polarity (GO:0061162)2.49936357
99regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.48761486
100cell migration in hindbrain (GO:0021535)2.48314954
101non-canonical Wnt signaling pathway (GO:0035567)2.48163016
102positive regulation of axon extension (GO:0045773)2.47903846
103protein targeting to plasma membrane (GO:0072661)2.47774808
104protein localization to endosome (GO:0036010)2.47530352
105positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.47133411
106neuron remodeling (GO:0016322)2.47132230
107trabecula formation (GO:0060343)2.47006604
108myoblast fusion (GO:0007520)2.45907332
109positive regulation of glycogen biosynthetic process (GO:0045725)2.45777316
110proline transport (GO:0015824)2.45549819
111synaptic vesicle docking involved in exocytosis (GO:0016081)2.45502649
112muscle cell fate commitment (GO:0042693)2.45301437
113positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.44032904
114regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.43832313
115spinal cord development (GO:0021510)2.43615142
116extracellular matrix assembly (GO:0085029)2.42978083
117developmental growth involved in morphogenesis (GO:0060560)2.42801220
118regulation of early endosome to late endosome transport (GO:2000641)2.42394242
119stress fiber assembly (GO:0043149)2.41320701
120regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.40772034
121cell communication involved in cardiac conduction (GO:0086065)2.40170311
122regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.39574286
123epithelial cell-cell adhesion (GO:0090136)2.39299086
124outer ear morphogenesis (GO:0042473)2.38870776
125myofibril assembly (GO:0030239)2.38427357
126neural tube development (GO:0021915)2.38226784
127cellular potassium ion homeostasis (GO:0030007)2.37666651
128positive regulation of synapse assembly (GO:0051965)2.37436355
129establishment or maintenance of apical/basal cell polarity (GO:0035088)2.37431102
130establishment or maintenance of bipolar cell polarity (GO:0061245)2.37431102
131regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.36982890
132regulation of synapse structural plasticity (GO:0051823)2.36967366
133dendrite morphogenesis (GO:0048813)2.36539757
134exploration behavior (GO:0035640)2.36318032
135metanephric mesenchyme development (GO:0072075)2.36311473
136chondrocyte development (GO:0002063)2.34949088
137regulation of axon guidance (GO:1902667)2.34927119
138cerebral cortex radially oriented cell migration (GO:0021799)2.34315798
139cell migration involved in heart development (GO:0060973)2.34187939
140membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.33579352
141syncytium formation by plasma membrane fusion (GO:0000768)2.32712707
142neuron recognition (GO:0008038)2.32326979
143dendritic spine organization (GO:0097061)2.31201058
144response to parathyroid hormone (GO:0071107)2.30448116
145positive regulation of axonogenesis (GO:0050772)2.29965434
146negative regulation of potassium ion transmembrane transport (GO:1901380)2.29702204
147ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.28330746
148mating behavior (GO:0007617)2.28283437
149cell adhesion mediated by integrin (GO:0033627)2.27963074
150central nervous system projection neuron axonogenesis (GO:0021952)2.27832131
151growth hormone secretion (GO:0030252)2.27717404
152negative regulation of cartilage development (GO:0061037)2.27163884
153neuron projection extension (GO:1990138)2.26366640
154positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.25626887
155potassium ion import (GO:0010107)2.25386834
156paraxial mesoderm development (GO:0048339)2.25114190
157retinal ganglion cell axon guidance (GO:0031290)2.24923970
158negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.24882174
159glutamate secretion (GO:0014047)2.24647788
160renal system process involved in regulation of blood volume (GO:0001977)2.24389928
161mesenchymal-epithelial cell signaling (GO:0060638)2.24239393
162myelination in peripheral nervous system (GO:0022011)2.24164611
163peripheral nervous system axon ensheathment (GO:0032292)2.24164611
164basement membrane organization (GO:0071711)2.22897084
165endocardial cushion development (GO:0003197)2.22838042
166negative regulation of embryonic development (GO:0045992)2.21522651
167negative regulation of axon extension (GO:0030517)2.21070186
168regulation of membrane repolarization (GO:0060306)2.19743966
169Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.19089907
170renal system development (GO:0072001)2.19075702
171kidney mesenchyme development (GO:0072074)2.18963553
172innervation (GO:0060384)2.18954675
173mesenchyme morphogenesis (GO:0072132)2.18869545

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.61311266
2EZH2_22144423_ChIP-Seq_EOC_Human3.92497776
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.58174600
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89480666
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.85718935
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.85718935
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.70956520
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59027970
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56952337
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.56860508
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54253553
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.52391316
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48855283
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41370649
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28656406
16RNF2_27304074_Chip-Seq_ESCs_Mouse2.14825411
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05667260
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.04785727
19DROSHA_22980978_ChIP-Seq_HELA_Human1.98968486
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96401763
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.93741875
22EP300_21415370_ChIP-Seq_HL-1_Mouse1.91585207
23WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.90508546
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.85517854
25EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.85058614
26ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.82024975
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.81765099
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.80112393
29* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.76224651
30AR_21572438_ChIP-Seq_LNCaP_Human1.73704510
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71716448
32RACK7_27058665_Chip-Seq_MCF-7_Human1.70059414
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.69291610
34ZNF263_19887448_ChIP-Seq_K562_Human1.67756283
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.66607872
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64939058
37GBX2_23144817_ChIP-Seq_PC3_Human1.62743617
38TET1_21451524_ChIP-Seq_MESCs_Mouse1.61558623
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61202999
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.58810286
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58209443
42RING1B_27294783_Chip-Seq_ESCs_Mouse1.53299835
43* KDM2B_26808549_Chip-Seq_K562_Human1.51676046
44SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.48338380
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46567594
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.42959179
47SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41080600
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.38567381
49WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34946347
50RING1B_27294783_Chip-Seq_NPCs_Mouse1.34739069
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32867615
52TP53_22127205_ChIP-Seq_IMR90_Human1.32705953
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.32491334
54* TET1_21490601_ChIP-Seq_MESCs_Mouse1.32371174
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28902305
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27577724
57* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27531861
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27018135
59* SA1_27219007_Chip-Seq_ERYTHROID_Human1.26900671
60KDM2B_26808549_Chip-Seq_DND41_Human1.26782985
61* CREB1_26743006_Chip-Seq_LNCaP_Human1.25320063
62PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23647878
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22481190
64ISL1_27105846_Chip-Seq_CPCs_Mouse1.21753701
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21292692
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20222547
67CLOCK_20551151_ChIP-Seq_293T_Human1.19906837
68P68_20966046_ChIP-Seq_HELA_Human1.19837160
69CJUN_26792858_Chip-Seq_BT549_Human1.19784431
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.19594342
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18932175
72* SMC4_20622854_ChIP-Seq_HELA_Human1.18516297
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17653102
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17143700
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16836121
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15438022
77* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15310912
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.15050537
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.14605851
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13793308
81RARB_27405468_Chip-Seq_BRAIN_Mouse1.12655014
82DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12398887
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12087841
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12062390
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.11780519
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11494936
87* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10749523
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10461782
89* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10213030
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09035481
91ZNF274_21170338_ChIP-Seq_K562_Hela1.08342727
92REST_21632747_ChIP-Seq_MESCs_Mouse1.07743267
93* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06927820
94TP53_18474530_ChIP-ChIP_U2OS_Human1.06773032
95* TP63_22573176_ChIP-Seq_HFKS_Human1.06633269
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06330118
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04580387
98* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04553460
99AR_19668381_ChIP-Seq_PC3_Human1.04529062
100DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04218541
101NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04182480
102TP53_16413492_ChIP-PET_HCT116_Human1.03879934
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02489888
104NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01683855
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01084882
106AHR_22903824_ChIP-Seq_MCF-7_Human1.00838283
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00060501
108OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99860971
109ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99014651
110SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98852309
111SA1_27219007_Chip-Seq_Bcells_Human0.96451791
112SMAD4_21799915_ChIP-Seq_A2780_Human0.96327992
113PIAS1_25552417_ChIP-Seq_VCAP_Human0.94871573
114SOX2_21211035_ChIP-Seq_LN229_Gbm0.94484349
115UBF1/2_26484160_Chip-Seq_HMECs_Human0.94455434
116ARNT_22903824_ChIP-Seq_MCF-7_Human0.94157986
117* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93722365
118STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.93448029
119PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92568742
120* TBX20_22328084_ChIP-Seq_HEART_Mouse0.92435771
121* TBX20_22080862_ChIP-Seq_HEART_Mouse0.92435771
122KDM2B_26808549_Chip-Seq_JURKAT_Human0.91864753
123ESR1_20079471_ChIP-ChIP_T-47D_Human0.90712052
124* CTCF_27219007_Chip-Seq_Bcells_Human0.90621094
125TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90015249
126* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89812318
127BCAT_22108803_ChIP-Seq_LS180_Human0.89523274
128* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.89492852
129RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89330622
130* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89009213
131* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.88646752
132* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88510890
133SMAD4_21741376_ChIP-Seq_HESCs_Human0.87850444
134NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86271081
135NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86271081
136TP53_23651856_ChIP-Seq_MEFs_Mouse0.85546674
137SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85394365
138LXR_22292898_ChIP-Seq_THP-1_Human0.85179195
139* REST_18959480_ChIP-ChIP_MESCs_Mouse0.84452841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.21905567
2MP0005503_abnormal_tendon_morphology4.73120345
3MP0005275_abnormal_skin_tensile4.41041737
4MP0000751_myopathy2.98693668
5MP0000579_abnormal_nail_morphology2.96679698
6MP0003705_abnormal_hypodermis_morpholog2.96291753
7MP0003279_aneurysm2.67584448
8MP0001958_emphysema2.65121033
9MP0005409_darkened_coat_color2.57852199
10MP0005623_abnormal_meninges_morphology2.56473365
11MP0004272_abnormal_basement_membrane2.52630805
12MP0000566_synostosis2.48971819
13MP0002822_catalepsy2.30591588
14MP0003122_maternal_imprinting2.15270090
15MP0004859_abnormal_synaptic_plasticity2.08753722
16MP0002108_abnormal_muscle_morphology2.01822176
17MP0004858_abnormal_nervous_system1.95719112
18MP0001849_ear_inflammation1.92656018
19MP0003329_amyloid_beta_deposits1.89176232
20MP0009379_abnormal_foot_pigmentation1.82330665
21MP0008789_abnormal_olfactory_epithelium1.79166105
22MP0005499_abnormal_olfactory_system1.78404263
23MP0005394_taste/olfaction_phenotype1.78404263
24MP0002837_dystrophic_cardiac_calcinosis1.75745265
25MP0005508_abnormal_skeleton_morphology1.71406225
26MP0003283_abnormal_digestive_organ1.71351650
27MP0003385_abnormal_body_wall1.69028096
28MP0001299_abnormal_eye_distance/1.65807900
29MP0009250_abnormal_appendicular_skeleto1.65381496
30MP0000467_abnormal_esophagus_morphology1.62982516
31MP0004084_abnormal_cardiac_muscle1.62685186
32MP0005257_abnormal_intraocular_pressure1.55957679
33MP0000534_abnormal_ureter_morphology1.51008299
34MP0009384_cardiac_valve_regurgitation1.49353176
35MP0001188_hyperpigmentation1.48734525
36MP0005360_urolithiasis1.48585364
37MP0010030_abnormal_orbit_morphology1.45993660
38MP0009780_abnormal_chondrocyte_physiolo1.45755730
39MP0000678_abnormal_parathyroid_gland1.37848550
40MP0003635_abnormal_synaptic_transmissio1.37273136
41MP0006054_spinal_hemorrhage1.37005403
42MP0002896_abnormal_bone_mineralization1.36308371
43MP0000013_abnormal_adipose_tissue1.30443136
44MP0004145_abnormal_muscle_electrophysio1.28113803
45MP0002060_abnormal_skin_morphology1.26417889
46MP0002282_abnormal_trachea_morphology1.26193708
47MP0009840_abnormal_foam_cell1.25768368
48MP0004215_abnormal_myocardial_fiber1.21910903
49MP0005423_abnormal_somatic_nervous1.21527890
50MP0003942_abnormal_urinary_system1.16468534
51MP0004270_analgesia1.15634135
52MP0001348_abnormal_lacrimal_gland1.15588717
53MP0000428_abnormal_craniofacial_morphol1.14319522
54MP0006138_congestive_heart_failure1.13861151
55MP0004036_abnormal_muscle_relaxation1.13508695
56MP0001968_abnormal_touch/_nociception1.13470144
57MP0003115_abnormal_respiratory_system1.13154965
58MP0003566_abnormal_cell_adhesion1.11574989
59MP0003861_abnormal_nervous_system1.11498802
60MP0004087_abnormal_muscle_fiber1.10935555
61MP0002295_abnormal_pulmonary_circulatio1.10619151
62MP0003879_abnormal_hair_cell1.10268891
63MP0002089_abnormal_postnatal_growth/wei1.09797939
64MP0004134_abnormal_chest_morphology1.08196080
65MP0005369_muscle_phenotype1.08137239
66MP0000538_abnormal_urinary_bladder1.07964592
67MP0002653_abnormal_ependyma_morphology1.06306992
68MP0002098_abnormal_vibrissa_morphology1.04925283
69MP0000749_muscle_degeneration1.04699893
70MP0000750_abnormal_muscle_regeneration1.04410064
71MP0005330_cardiomyopathy1.03989703
72MP0002796_impaired_skin_barrier1.03831660
73MP0003119_abnormal_digestive_system1.03785362
74MP0002882_abnormal_neuron_morphology1.03641402
75MP0004233_abnormal_muscle_weight1.02554154
76MP0003137_abnormal_impulse_conducting1.01669837
77MP0003045_fibrosis1.01293847
78MP0000537_abnormal_urethra_morphology1.01272040
79MP0002972_abnormal_cardiac_muscle1.01163960
80MP0000733_abnormal_muscle_development1.00424095
81MP0000759_abnormal_skeletal_muscle0.99860582
82MP0005197_abnormal_uvea_morphology0.99280096
83MP0010234_abnormal_vibrissa_follicle0.99084530
84MP0005620_abnormal_muscle_contractility0.98804608
85MP0008775_abnormal_heart_ventricle0.98138521
86MP0002184_abnormal_innervation0.96435719
87MP0005501_abnormal_skin_physiology0.95018878
88MP0002733_abnormal_thermal_nociception0.94010240
89MP0005670_abnormal_white_adipose0.93944224
90MP0000049_abnormal_middle_ear0.93036535
91MP0002752_abnormal_somatic_nervous0.92982442
92MP0003755_abnormal_palate_morphology0.92022871
93MP0002932_abnormal_joint_morphology0.91713834
94MP0004484_altered_response_of0.91273021
95MP0003091_abnormal_cell_migration0.90838134
96MP0000163_abnormal_cartilage_morphology0.90411304
97MP0000778_abnormal_nervous_system0.89830171
98MP0002063_abnormal_learning/memory/cond0.87940210
99MP0009046_muscle_twitch0.87835031
100MP0003453_abnormal_keratinocyte_physiol0.87459017
101MP0002734_abnormal_mechanical_nocicepti0.86925053
102MP0001177_atelectasis0.86846994
103MP0002152_abnormal_brain_morphology0.86572020
104MP0002106_abnormal_muscle_physiology0.86284853
105MP0001243_abnormal_dermal_layer0.85928814
106MP0004085_abnormal_heartbeat0.85543993
107MP0002909_abnormal_adrenal_gland0.85479463
108MP0002116_abnormal_craniofacial_bone0.85370530
109MP0000747_muscle_weakness0.85347775
110MP0002115_abnormal_skeleton_extremities0.84849879
111MP0001970_abnormal_pain_threshold0.83684380
112MP0003880_abnormal_central_pattern0.83292700
113MP0006276_abnormal_autonomic_nervous0.83145552
114MP0002697_abnormal_eye_size0.83032477
115MP0003123_paternal_imprinting0.82984562
116MP0001544_abnormal_cardiovascular_syste0.82134518
117MP0005385_cardiovascular_system_phenoty0.82134518
118MP0006292_abnormal_olfactory_placode0.81837922
119MP0003121_genomic_imprinting0.81816012
120MP0002234_abnormal_pharynx_morphology0.81750013
121MP0000762_abnormal_tongue_morphology0.81266986
122MP0004885_abnormal_endolymph0.81041935
123MP0001542_abnormal_bone_strength0.80948393
124MP0009053_abnormal_anal_canal0.80243164
125MP0002249_abnormal_larynx_morphology0.79439044
126MP0003935_abnormal_craniofacial_develop0.78890539
127MP0005171_absent_coat_pigmentation0.78746843
128MP0009745_abnormal_behavioral_response0.78620690
129MP0010368_abnormal_lymphatic_system0.78361073
130MP0000767_abnormal_smooth_muscle0.77063177
131MP0004811_abnormal_neuron_physiology0.76604625
132MP0003315_abnormal_perineum_morphology0.76365209
133MP0002081_perinatal_lethality0.75796310
134MP0000003_abnormal_adipose_tissue0.74864859
135MP0000026_abnormal_inner_ear0.74384389
136MP0002064_seizures0.73704814
137MP0000955_abnormal_spinal_cord0.72516346
138MP0008569_lethality_at_weaning0.72374010
139MP0000377_abnormal_hair_follicle0.72358662
140MP0002233_abnormal_nose_morphology0.69792771
141MP0002735_abnormal_chemical_nociception0.68523598
142MP0010630_abnormal_cardiac_muscle0.68254477
143MP0000462_abnormal_digestive_system0.67766203

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.33615501
2Premature rupture of membranes (HP:0001788)5.89213849
3Broad metatarsal (HP:0001783)4.57919208
4Shallow orbits (HP:0000586)4.19607252
5Ankle contracture (HP:0006466)4.11310058
6Atrophic scars (HP:0001075)4.02163110
7Bladder diverticulum (HP:0000015)3.98876718
8Pterygium (HP:0001059)3.92447738
9Fragile nails (HP:0001808)3.76466104
10Popliteal pterygium (HP:0009756)3.75691540
11Fragile skin (HP:0001030)3.70046284
12Aortic dissection (HP:0002647)3.60659862
13Type 1 muscle fiber predominance (HP:0003803)3.57297096
14Fetal akinesia sequence (HP:0001989)3.45085095
15Cerebral aneurysm (HP:0004944)3.44185697
16Soft skin (HP:0000977)3.39128152
17Follicular hyperkeratosis (HP:0007502)3.24731994
18Increased connective tissue (HP:0009025)3.22018503
19Increased variability in muscle fiber diameter (HP:0003557)3.12322305
20Abnormality of dentin (HP:0010299)3.08398288
21Milia (HP:0001056)3.00363431
22Spinal rigidity (HP:0003306)3.00188739
23Dilatation of the ascending aorta (HP:0005111)2.99128367
24Bowel diverticulosis (HP:0005222)2.97911451
25Neonatal short-limb short stature (HP:0008921)2.97403943
26Genu recurvatum (HP:0002816)2.94392019
27Abnormality of the neuromuscular junction (HP:0003398)2.92642397
28Fatigable weakness (HP:0003473)2.92642397
29Mitral valve prolapse (HP:0001634)2.87713143
30Peritonitis (HP:0002586)2.80595907
31Neurofibrillary tangles (HP:0002185)2.80109774
32Akinesia (HP:0002304)2.77056018
33Mildly elevated creatine phosphokinase (HP:0008180)2.75751726
34Wrist flexion contracture (HP:0001239)2.75712534
35Thin ribs (HP:0000883)2.64361833
36Hypoventilation (HP:0002791)2.61604588
37Hyperextensible skin (HP:0000974)2.60472870
38Abnormality of placental membranes (HP:0011409)2.60017332
39Amniotic constriction ring (HP:0009775)2.60017332
40Abnormality of skeletal muscle fiber size (HP:0012084)2.58735411
41Aortic aneurysm (HP:0004942)2.57795075
42Overgrowth (HP:0001548)2.52929259
43Wormian bones (HP:0002645)2.52612343
44Slender build (HP:0001533)2.51241231
45Cerebral inclusion bodies (HP:0100314)2.42921630
46Natal tooth (HP:0000695)2.42147753
47Flat cornea (HP:0007720)2.40011087
48Blue sclerae (HP:0000592)2.38847015
49Short 4th metacarpal (HP:0010044)2.37349430
50Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.37349430
51Deviation of the hallux (HP:0010051)2.29346834
52Myokymia (HP:0002411)2.25044713
53Narrow nasal bridge (HP:0000446)2.24695729
54Alopecia of scalp (HP:0002293)2.22348019
55Short nail (HP:0001799)2.21778924
56Hallux valgus (HP:0001822)2.20894791
57Abnormality of the aortic arch (HP:0012303)2.20428880
58Muscle fiber splitting (HP:0003555)2.19603524
59Renal duplication (HP:0000075)2.18321166
60Joint laxity (HP:0001388)2.16977350
61Arterial tortuosity (HP:0005116)2.16787887
62Plantar hyperkeratosis (HP:0007556)2.16762459
63Hand muscle atrophy (HP:0009130)2.16107584
64Buphthalmos (HP:0000557)2.15409853
65Renovascular hypertension (HP:0100817)2.12162660
66Infantile muscular hypotonia (HP:0008947)2.11219993
67Easy fatigability (HP:0003388)2.11019223
68Wide anterior fontanel (HP:0000260)2.10486601
69Sudden death (HP:0001699)2.10453816
70Aplasia of the musculature (HP:0100854)2.07976323
71Abnormality of the 4th metacarpal (HP:0010012)2.06069548
72Striae distensae (HP:0001065)2.05972785
73Long palpebral fissure (HP:0000637)2.03857861
74Supranuclear gaze palsy (HP:0000605)2.02396899
75Rib fusion (HP:0000902)2.01845688
76Abnormality of the calf musculature (HP:0001430)2.01504676
77Obstructive sleep apnea (HP:0002870)2.01330074
78Cervical subluxation (HP:0003308)2.00331799
79Aplasia involving bones of the upper limbs (HP:0009823)1.99345160
80Aplasia of the phalanges of the hand (HP:0009802)1.99345160
81Aplasia involving bones of the extremities (HP:0009825)1.99345160
82Neoplasm of the heart (HP:0100544)1.99137323
83Mitral regurgitation (HP:0001653)1.98914612
84Abnormality of the lower motor neuron (HP:0002366)1.95546126
85Bronchomalacia (HP:0002780)1.95229694
86Round ear (HP:0100830)1.94877381
87Ulnar bowing (HP:0003031)1.93893996
88Polyphagia (HP:0002591)1.93745042
89Nail dystrophy (HP:0008404)1.93561150
90Biconcave vertebral bodies (HP:0004586)1.93163786
91Coronal craniosynostosis (HP:0004440)1.92764505
92Hyperacusis (HP:0010780)1.92641241
93Broad ribs (HP:0000885)1.91443828
94Thin bony cortex (HP:0002753)1.89662364
95Upper limb amyotrophy (HP:0009129)1.89127209
96Distal upper limb amyotrophy (HP:0007149)1.89127209
97Hypoplasia of dental enamel (HP:0006297)1.88960620
98Bulbar palsy (HP:0001283)1.87034917
99Venous abnormality (HP:0002624)1.86636252
100Venous insufficiency (HP:0005293)1.86166917
101Osteoarthritis (HP:0002758)1.85939830
102Morphological abnormality of the middle ear (HP:0008609)1.85908235
103Abnormality of nail color (HP:0100643)1.85108612
104Shawl scrotum (HP:0000049)1.82154530
105Elbow flexion contracture (HP:0002987)1.81742515
106Aneurysm (HP:0002617)1.81377257
107Broad long bones (HP:0005622)1.80481137
108Elfin facies (HP:0004428)1.79565022
109Lower limb amyotrophy (HP:0007210)1.79102555
110Camptodactyly of toe (HP:0001836)1.77993340
111Thick nail (HP:0001805)1.77938909
112Long toe (HP:0010511)1.77910951
113Vascular tortuosity (HP:0004948)1.76958053
114Ectopia lentis (HP:0001083)1.76824480
115Vertebral compression fractures (HP:0002953)1.76591566
116Protruding ear (HP:0000411)1.76052578
117Onycholysis (HP:0001806)1.75852691
118Down-sloping shoulders (HP:0200021)1.75072413
119Advanced eruption of teeth (HP:0006288)1.74994325
120Mild short stature (HP:0003502)1.74977969
121Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74775716
122Turricephaly (HP:0000262)1.73732685
123Bell-shaped thorax (HP:0001591)1.73350151
124Enlarged penis (HP:0000040)1.73133346
125Mesomelia (HP:0003027)1.71656508
126Scapular winging (HP:0003691)1.71502382
127Overriding aorta (HP:0002623)1.71135894
128Congenital glaucoma (HP:0001087)1.70456794
129Lymphangioma (HP:0100764)1.70299530
130Asymmetry of the thorax (HP:0001555)1.70007071
131Neonatal onset (HP:0003623)1.69854037
132Torticollis (HP:0000473)1.69454961
133Hyporeflexia of lower limbs (HP:0002600)1.69109798
134Atrial fibrillation (HP:0005110)1.68909970
135Hypercortisolism (HP:0001578)1.68338130
136Osteopenia (HP:0000938)1.68228048
137Hyperparathyroidism (HP:0000843)1.68188142
138Limb-girdle muscle weakness (HP:0003325)1.66687353
139Abnormality of the distal phalanges of the toes (HP:0010182)1.66633567
140Disproportionate tall stature (HP:0001519)1.66428569
141Flat acetabular roof (HP:0003180)1.66365224
142Achilles tendon contracture (HP:0001771)1.66105285
143Hip contracture (HP:0003273)1.66056786
144Insomnia (HP:0100785)1.65946421
145Hypercalcemia (HP:0003072)1.65673345
146Short hallux (HP:0010109)1.65380325
147High anterior hairline (HP:0009890)1.63130411
148Distal lower limb amyotrophy (HP:0008944)1.61702210
149Spina bifida occulta (HP:0003298)1.60835248
150Arthrogryposis multiplex congenita (HP:0002804)1.60524419
151Ridged nail (HP:0001807)1.58635645
152Muscle fiber atrophy (HP:0100295)1.58617301
153Trismus (HP:0000211)1.56895859
154Generalized amyotrophy (HP:0003700)1.56427536
155Arnold-Chiari malformation (HP:0002308)1.56007407
156Tibial bowing (HP:0002982)1.55012722
157Pointed chin (HP:0000307)1.53677305
158Bowing of the arm (HP:0006488)1.53616714
159Bowed forearm bones (HP:0003956)1.53616714
160Deep palmar crease (HP:0006191)1.52082318
161Hypercalciuria (HP:0002150)1.51270738

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.02782285
2MST1R3.93150107
3DDR23.35471255
4TRIB33.32617271
5PDGFRA3.18557655
6LATS23.14560018
7TTN2.50294654
8MUSK2.30722553
9NTRK32.29258007
10EPHB22.20675528
11NTRK12.13518114
12MET2.10591145
13PKN22.06076136
14LMTK22.05754023
15RIPK12.02760700
16EPHB11.97892248
17PHKG11.94995194
18PHKG21.94995194
19CASK1.94717649
20PRKD31.90587872
21PAK61.83160880
22MAP3K91.76598879
23MARK11.74024258
24MAP3K41.67875290
25PAK31.65626194
26MINK11.64256239
27NTRK21.56391655
28IRAK31.55539278
29ARAF1.49252870
30DMPK1.48859255
31LATS11.46143626
32TESK11.45026963
33FER1.44434198
34MOS1.44302282
35MYLK1.40820925
36CAMKK11.39352413
37SIK11.38916278
38BMX1.34242541
39ROCK11.31626303
40MAP3K61.28290512
41DAPK21.26333215
42STK381.23009509
43PLK21.21955791
44BRAF1.20054848
45RET1.19714231
46PRKCH1.17489586
47DYRK21.12561201
48FGFR21.11233417
49KSR21.10905469
50PRPF4B1.10531165
51PAK41.09307976
52CAMK1G1.09158832
53PAK21.08711715
54PTK21.08545009
55PTK2B1.05922559
56TAOK11.05609684
57PDGFRB1.04447361
58CDC42BPA1.03317880
59TYRO31.01112842
60ICK0.97079628
61FGFR10.96858819
62ILK0.93751575
63ERN10.92921641
64PTK60.89747785
65STK160.88963756
66ERBB30.88545935
67MAPK130.86917523
68PIM20.86818174
69KSR10.86643441
70ROCK20.86300895
71MAP2K40.86159175
72NME20.85888498
73ADRBK10.83604147
74SMG10.82950785
75DYRK1B0.81732746
76LIMK10.80030864
77WNK10.78731871
78ABL20.78597931
79UHMK10.78402463
80RPS6KA20.78334600
81CAMK1D0.76232437
82CDK50.76134589
83GRK50.74276698
84PRKD10.73984308
85DAPK30.73637037
86EPHA40.71207362
87FGFR40.70494205
88MAP2K10.70469070
89STK240.69372615
90NEK10.68371259
91CDK140.68261603
92ALK0.66434820
93CDK150.66303606
94EEF2K0.64990819
95CDK180.62888593
96CAMK2A0.62780303
97PRKCG0.61678893
98SIK20.60970438
99STK110.60858680
100MAP3K110.60793213
101PRKCE0.59874474
102EPHA30.58649751
103SGK4940.56894064
104SGK2230.56894064
105CDK11A0.55478638
106MAP2K70.54104451
107MAP3K20.53992599
108MTOR0.52223131
109PRKCI0.51832056
110PRKD20.51592420
111CAMK40.51389889
112PIK3CA0.48318742
113LRRK20.48188653
114PDK40.47750314
115PDK30.47750314
116RPS6KC10.46226346
117RPS6KL10.46226346
118OBSCN0.46004316
119SRC0.45124178
120MARK20.42730349
121ERBB40.42012943
122CAMK10.41887116
123CAMKK20.41521871
124CDK80.41226557
125MAP2K20.38821170
126ERBB20.38274360
127PRKG20.37658278
128SCYL20.35607772
129PRKCZ0.35394323
130MAP3K70.35105163
131MAP3K100.34605333
132SGK30.34100587
133RPS6KA60.34051744
134CAMK2D0.34007964
135CSNK1G20.32689405
136CAMK2G0.28466296
137MAPK80.26631236
138IRAK20.26560950
139WNK40.25814606
140GSK3A0.25546244
141PDPK10.25073140

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.62769439
2Cyanoamino acid metabolism_Homo sapiens_hsa004602.32972385
3Dilated cardiomyopathy_Homo sapiens_hsa054142.29802293
4Notch signaling pathway_Homo sapiens_hsa043302.07158079
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.00566398
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.98395749
7Protein digestion and absorption_Homo sapiens_hsa049741.90751528
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90470945
9Focal adhesion_Homo sapiens_hsa045101.85323280
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.77189344
11Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76353457
12Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.74894704
13Hedgehog signaling pathway_Homo sapiens_hsa043401.67654238
14Circadian entrainment_Homo sapiens_hsa047131.64746138
15Synaptic vesicle cycle_Homo sapiens_hsa047211.58294478
16Cardiac muscle contraction_Homo sapiens_hsa042601.56679139
17Basal cell carcinoma_Homo sapiens_hsa052171.56134758
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.55997210
19Nicotine addiction_Homo sapiens_hsa050331.54334701
20GABAergic synapse_Homo sapiens_hsa047271.50502570
21Gastric acid secretion_Homo sapiens_hsa049711.42623704
22Axon guidance_Homo sapiens_hsa043601.39764010
23Sulfur relay system_Homo sapiens_hsa041221.39030499
24Olfactory transduction_Homo sapiens_hsa047401.37549764
25Salivary secretion_Homo sapiens_hsa049701.33548095
26Glutamatergic synapse_Homo sapiens_hsa047241.33513554
27Glioma_Homo sapiens_hsa052141.33164228
28Proteoglycans in cancer_Homo sapiens_hsa052051.32332917
29Prion diseases_Homo sapiens_hsa050201.31915222
30Amoebiasis_Homo sapiens_hsa051461.31242027
31Melanogenesis_Homo sapiens_hsa049161.31165451
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30879045
33Renin secretion_Homo sapiens_hsa049241.29368556
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29346709
35Amphetamine addiction_Homo sapiens_hsa050311.28806068
36Dopaminergic synapse_Homo sapiens_hsa047281.28619938
37Oxytocin signaling pathway_Homo sapiens_hsa049211.28346328
38Gap junction_Homo sapiens_hsa045401.27225180
39Cholinergic synapse_Homo sapiens_hsa047251.27117596
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.26801689
41GnRH signaling pathway_Homo sapiens_hsa049121.26790153
42Cocaine addiction_Homo sapiens_hsa050301.26618543
43Long-term potentiation_Homo sapiens_hsa047201.25769507
44Estrogen signaling pathway_Homo sapiens_hsa049151.25238315
45Insulin secretion_Homo sapiens_hsa049111.24190393
46Hippo signaling pathway_Homo sapiens_hsa043901.23963969
47Bile secretion_Homo sapiens_hsa049761.22740191
48Morphine addiction_Homo sapiens_hsa050321.22147527
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18059314
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15582653
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07652842
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06485060
53cAMP signaling pathway_Homo sapiens_hsa040241.05188095
54Phenylalanine metabolism_Homo sapiens_hsa003601.05066069
55Taste transduction_Homo sapiens_hsa047421.03471310
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02515719
57Calcium signaling pathway_Homo sapiens_hsa040201.01653526
58Vascular smooth muscle contraction_Homo sapiens_hsa042701.00802775
59Arginine biosynthesis_Homo sapiens_hsa002200.99943429
60Wnt signaling pathway_Homo sapiens_hsa043100.99865794
61Adherens junction_Homo sapiens_hsa045200.94725095
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.94649785
63Long-term depression_Homo sapiens_hsa047300.94414059
64Dorso-ventral axis formation_Homo sapiens_hsa043200.94322649
65Vibrio cholerae infection_Homo sapiens_hsa051100.93590638
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91189702
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90323774
68Type II diabetes mellitus_Homo sapiens_hsa049300.90171254
69Thyroid hormone synthesis_Homo sapiens_hsa049180.89981940
70Bladder cancer_Homo sapiens_hsa052190.89246613
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88750568
72Melanoma_Homo sapiens_hsa052180.87935226
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.86510379
74Phototransduction_Homo sapiens_hsa047440.86397076
75Endometrial cancer_Homo sapiens_hsa052130.86022726
76TGF-beta signaling pathway_Homo sapiens_hsa043500.85712703
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.85375813
78Rap1 signaling pathway_Homo sapiens_hsa040150.85139301
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84474709
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.82766403
81Fat digestion and absorption_Homo sapiens_hsa049750.82609949
82ErbB signaling pathway_Homo sapiens_hsa040120.81976011
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81625447
84Serotonergic synapse_Homo sapiens_hsa047260.79746088
85Tight junction_Homo sapiens_hsa045300.79293651
86Renin-angiotensin system_Homo sapiens_hsa046140.78935864
87Starch and sucrose metabolism_Homo sapiens_hsa005000.78542193
88Insulin signaling pathway_Homo sapiens_hsa049100.77475865
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.76713906
90Histidine metabolism_Homo sapiens_hsa003400.74814937
91mTOR signaling pathway_Homo sapiens_hsa041500.74506417
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74249763
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72506713
94MAPK signaling pathway_Homo sapiens_hsa040100.71345550
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70880897
96Galactose metabolism_Homo sapiens_hsa000520.70788772
97Renal cell carcinoma_Homo sapiens_hsa052110.70323696
98VEGF signaling pathway_Homo sapiens_hsa043700.69545134
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69221526
100Chronic myeloid leukemia_Homo sapiens_hsa052200.69140106
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68497216
102Glucagon signaling pathway_Homo sapiens_hsa049220.67139705
103Retinol metabolism_Homo sapiens_hsa008300.66943785
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66656167
105Colorectal cancer_Homo sapiens_hsa052100.66033052
106Pathways in cancer_Homo sapiens_hsa052000.65785170
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65526375
108Ras signaling pathway_Homo sapiens_hsa040140.65361029
109MicroRNAs in cancer_Homo sapiens_hsa052060.64966831
110Platelet activation_Homo sapiens_hsa046110.64772968
111Viral myocarditis_Homo sapiens_hsa054160.62980497
112Tyrosine metabolism_Homo sapiens_hsa003500.62196327
113PPAR signaling pathway_Homo sapiens_hsa033200.60981083
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60504830
115Arginine and proline metabolism_Homo sapiens_hsa003300.59084959
116Insulin resistance_Homo sapiens_hsa049310.57752926
117Small cell lung cancer_Homo sapiens_hsa052220.56998807
118Endocytosis_Homo sapiens_hsa041440.56166272
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55593041
120Ovarian steroidogenesis_Homo sapiens_hsa049130.54819433
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54382873
122AMPK signaling pathway_Homo sapiens_hsa041520.50092570
123Oocyte meiosis_Homo sapiens_hsa041140.50028488
124Biosynthesis of amino acids_Homo sapiens_hsa012300.50019208
125Pancreatic secretion_Homo sapiens_hsa049720.47959287
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46377540
127Thyroid cancer_Homo sapiens_hsa052160.44193521

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