ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axon ensheathment in central nervous system (GO:0032291)	5.25925555
2	central nervous system myelination (GO:0022010)	5.25925555
3	fatty acid elongation (GO:0030497)	4.30586037
4	L-phenylalanine catabolic process (GO:0006559)	3.84010089
5	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.84010089
6	behavioral response to nicotine (GO:0035095)	3.82724670
7	activated T cell proliferation (GO:0050798)	3.42345983
8	L-phenylalanine metabolic process (GO:0006558)	3.37734968
9	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.37734968
10	axon ensheathment (GO:0008366)	3.35953394
11	ensheathment of neurons (GO:0007272)	3.35953394
12	myelination (GO:0042552)	3.35896360
13	postsynaptic membrane organization (GO:0001941)	3.34827393
14	response to methylmercury (GO:0051597)	3.22928709
15	L-amino acid import (GO:0043092)	3.10514167
16	negative regulation of neurotransmitter secretion (GO:0046929)	3.09235354
17	negative regulation of neurotransmitter transport (GO:0051589)	3.02346338
18	neuron cell-cell adhesion (GO:0007158)	3.01371955
19	cAMP catabolic process (GO:0006198)	3.01049421
20	locomotory exploration behavior (GO:0035641)	2.99531508
21	membrane depolarization during action potential (GO:0086010)	2.99153035
22	adenosine receptor signaling pathway (GO:0001973)	2.97211817
23	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.96318960
24	glycerophospholipid catabolic process (GO:0046475)	2.93189000
25	aromatic amino acid family catabolic process (GO:0009074)	2.92350417
26	synaptic vesicle maturation (GO:0016188)	2.92114927
27	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.91340777
28	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.88843981
29	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.84934080
30	bile acid biosynthetic process (GO:0006699)	2.82284331
31	startle response (GO:0001964)	2.81466541
32	very long-chain fatty acid metabolic process (GO:0000038)	2.80094423
33	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.78569632
34	L-fucose catabolic process (GO:0042355)	2.78563108
35	fucose catabolic process (GO:0019317)	2.78563108
36	L-fucose metabolic process (GO:0042354)	2.78563108
37	regulation of neurotransmitter uptake (GO:0051580)	2.78381653
38	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	2.75694992
39	detection of light stimulus involved in visual perception (GO:0050908)	2.75391613
40	detection of light stimulus involved in sensory perception (GO:0050962)	2.75391613
41	alpha-linolenic acid metabolic process (GO:0036109)	2.75313173
42	protein K11-linked deubiquitination (GO:0035871)	2.72295751
43	serotonin metabolic process (GO:0042428)	2.72207518
44	auditory behavior (GO:0031223)	2.71789659
45	neuronal action potential propagation (GO:0019227)	2.71659771
46	gamma-aminobutyric acid transport (GO:0015812)	2.71400088
47	pyrimidine nucleobase catabolic process (GO:0006208)	2.68748745
48	synaptic transmission, glutamatergic (GO:0035249)	2.67063815
49	indole-containing compound catabolic process (GO:0042436)	2.66288580
50	indolalkylamine catabolic process (GO:0046218)	2.66288580
51	tryptophan catabolic process (GO:0006569)	2.66288580
52	indolalkylamine metabolic process (GO:0006586)	2.65193451
53	proline transport (GO:0015824)	2.64817530
54	presynaptic membrane organization (GO:0097090)	2.64728061
55	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.64681348
56	fatty-acyl-CoA biosynthetic process (GO:0046949)	2.64617936
57	DNA deamination (GO:0045006)	2.63503518
58	neural tube formation (GO:0001841)	2.63286962
59	negative regulation of protein localization to cell surface (GO:2000009)	2.63179700
60	neuronal action potential (GO:0019228)	2.62931831
61	neurotransmitter-gated ion channel clustering (GO:0072578)	2.62191956
62	long-chain fatty acid biosynthetic process (GO:0042759)	2.61002390
63	myelin maintenance (GO:0043217)	2.60203646
64	presynaptic membrane assembly (GO:0097105)	2.60131952
65	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.59836429
66	glutamate metabolic process (GO:0006536)	2.58467686
67	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.57007826
68	transmission of nerve impulse (GO:0019226)	2.55767995
69	establishment of protein localization to Golgi (GO:0072600)	2.55137487
70	primary amino compound metabolic process (GO:1901160)	2.54936293
71	auditory receptor cell stereocilium organization (GO:0060088)	2.53420395
72	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.53408440
73	adult walking behavior (GO:0007628)	2.52612738
74	cholesterol biosynthetic process (GO:0006695)	2.52280362
75	reflex (GO:0060004)	2.51837676
76	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.51802278
77	nerve growth factor signaling pathway (GO:0038180)	2.50936716
78	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.49784228
79	coenzyme catabolic process (GO:0009109)	2.48209795
80	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.47544514
81	cerebellar Purkinje cell differentiation (GO:0021702)	2.46906876
82	kidney morphogenesis (GO:0060993)	2.45818268
83	C4-dicarboxylate transport (GO:0015740)	2.45248565
84	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.44763017
85	indole-containing compound metabolic process (GO:0042430)	2.44695746
86	fatty-acyl-CoA metabolic process (GO:0035337)	2.42599393
87	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.42038602
88	bile acid metabolic process (GO:0008206)	2.41953851
89	long-chain fatty-acyl-CoA metabolic process (GO:0035336)	2.41329864
90	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.40936271
91	negative regulation of cell killing (GO:0031342)	2.40936271
92	regulation of neuronal synaptic plasticity (GO:0048168)	2.40611170
93	acyl-CoA biosynthetic process (GO:0071616)	2.40330599
94	thioester biosynthetic process (GO:0035384)	2.40330599
95	synaptic vesicle exocytosis (GO:0016079)	2.40283381
96	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.39857608
97	positive regulation of synaptic transmission, glutamatergic (GO:0051968)	2.39699412
98	nucleobase catabolic process (GO:0046113)	2.39531540
99	potassium ion import (GO:0010107)	2.38270696
100	nonmotile primary cilium assembly (GO:0035058)	2.38019659
101	retinal cone cell development (GO:0046549)	2.37624912
102	kynurenine metabolic process (GO:0070189)	2.37522270
103	establishment of mitochondrion localization (GO:0051654)	2.37280447
104	glutamate secretion (GO:0014047)	2.35774307
105	vocalization behavior (GO:0071625)	2.35638573
106	regulation of synaptic vesicle exocytosis (GO:2000300)	2.34830213
107	cellular ketone body metabolic process (GO:0046950)	2.34479950
108	dicarboxylic acid catabolic process (GO:0043649)	2.33453679
109	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.33322943
110	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.33172528
111	high-density lipoprotein particle remodeling (GO:0034375)	2.33108893
112	cholesterol efflux (GO:0033344)	2.32333075
113	glycosphingolipid biosynthetic process (GO:0006688)	2.32291441
114	tryptophan metabolic process (GO:0006568)	2.31021694
115	urinary tract smooth muscle contraction (GO:0014848)	2.30370488
116	amino acid import (GO:0043090)	2.29659803
117	adaptation of signaling pathway (GO:0023058)	2.29612936
118	heme transport (GO:0015886)	2.29316000
119	regulation of lipoprotein metabolic process (GO:0050746)	2.28650434
120	atrial cardiac muscle cell action potential (GO:0086014)	2.28218530
121	protein localization to cilium (GO:0061512)	2.28110543
122	oligodendrocyte differentiation (GO:0048709)	2.27496114
123	mating behavior (GO:0007617)	2.26847122
124	iron coordination entity transport (GO:1901678)	2.26832036
125	behavioral response to cocaine (GO:0048148)	2.26448677
126	mechanosensory behavior (GO:0007638)	2.26171150
127	glycine transport (GO:0015816)	2.25915442
128	potassium ion transmembrane transport (GO:0071805)	2.25483268
129	cellular potassium ion transport (GO:0071804)	2.25483268
130	peptidyl-tyrosine autophosphorylation (GO:0038083)	2.25129263
131	cellular potassium ion homeostasis (GO:0030007)	2.25024858
132	neuronal ion channel clustering (GO:0045161)	2.24830240
133	cellular response to interleukin-15 (GO:0071350)	2.24694337
134	membrane depolarization (GO:0051899)	2.24583783
135	regulation of long-term neuronal synaptic plasticity (GO:0048169)	2.24384658
136	regulation of dendritic spine morphogenesis (GO:0061001)	2.23888342
137	short-chain fatty acid metabolic process (GO:0046459)	2.23880783
138	regulation of cholesterol biosynthetic process (GO:0045540)	2.23199165
139	regulation of glutamate receptor signaling pathway (GO:1900449)	2.23165723
140	dendritic spine morphogenesis (GO:0060997)	2.22354204
141	long-term memory (GO:0007616)	2.21911107
142	neurotransmitter secretion (GO:0007269)	2.21890780
143	creatine metabolic process (GO:0006600)	2.21423754
144	protein targeting to Golgi (GO:0000042)	2.21224996
145	negative regulation of adenylate cyclase activity (GO:0007194)	2.21157223
146	action potential (GO:0001508)	2.20055409
147	regulation of synapse structural plasticity (GO:0051823)	2.18785106
148	neuron-neuron synaptic transmission (GO:0007270)	2.18152825
149	sterol biosynthetic process (GO:0016126)	2.17959996
150	reverse cholesterol transport (GO:0043691)	2.17620978
151	regulation of memory T cell differentiation (GO:0043380)	2.17271795
152	potassium ion transport (GO:0006813)	2.17116477
153	peptidyl-glutamic acid carboxylation (GO:0017187)	2.17032386
154	protein carboxylation (GO:0018214)	2.17032386
155	negative regulation of lipase activity (GO:0060192)	2.16946203
156	neuromuscular synaptic transmission (GO:0007274)	2.16746633
157	complement activation, alternative pathway (GO:0006957)	2.16601588
158	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.16385484
159	regulation of neurotransmitter transport (GO:0051588)	2.15945324
160	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.15578129
161	regulation of translation, ncRNA-mediated (GO:0045974)	2.15578129
162	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.15578129
163	glutamate receptor signaling pathway (GO:0007215)	2.15442432
164	axoneme assembly (GO:0035082)	2.15233658
165	regulation of action potential (GO:0098900)	2.15186921
166	regulation of synaptic vesicle transport (GO:1902803)	2.15033621
167	cysteine metabolic process (GO:0006534)	2.15010441
168	protein localization to synapse (GO:0035418)	2.14605250
169	prepulse inhibition (GO:0060134)	2.13966276
170	cyclic nucleotide catabolic process (GO:0009214)	2.13783621
171	response to auditory stimulus (GO:0010996)	2.13204283
172	neuromuscular process controlling balance (GO:0050885)	2.13171697
173	import into cell (GO:0098657)	2.11791660
174	membrane tubulation (GO:0097320)	2.11275925

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	2.86249917
2	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.79087572
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.68043506
4	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.35534696
5	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.28772537
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.25517466
7	VDR_22108803_ChIP-Seq_LS180_Human	2.23230861
8	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.02404848
9	MTF2_20144788_ChIP-Seq_MESCs_Mouse	2.01382730
10	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.99538080
11	DROSHA_22980978_ChIP-Seq_HELA_Human	1.98170896
12	* SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.97835823
13	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.97052615
14	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.94917768
15	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.94917768
16	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.94287512
17	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.88043947
18	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.85459444
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.81721095
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.81615148
21	AR_21572438_ChIP-Seq_LNCaP_Human	1.79555941
22	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.78760153
23	* RARB_27405468_Chip-Seq_BRAIN_Mouse	1.78151715
24	IGF1R_20145208_ChIP-Seq_DFB_Human	1.75836741
25	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.73855355
26	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.70737760
27	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.66737473
28	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.65642640
29	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.64809494
30	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.64083068
31	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.64064226
32	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.56474232
33	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.55080439
34	REST_21632747_ChIP-Seq_MESCs_Mouse	1.51471665
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.51263606
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.50000449
37	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.49121249
38	FUS_26573619_Chip-Seq_HEK293_Human	1.47431035
39	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.47112879
40	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.46873756
41	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.46410626
42	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.44275370
43	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.43226991
44	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.38146937
45	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38146937
46	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.36969056
47	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.36782557
48	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.32440324
49	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31468730
50	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.29283401
51	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.28601434
52	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.27449526
53	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.27204642
54	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.26643790
55	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.26227233
56	* ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.26092774
57	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.25831270
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.24448575
59	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.23996007
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.23392410
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23392410
62	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23034011
63	* SMAD4_21799915_ChIP-Seq_A2780_Human	1.21194357
64	* NANOG_18555785_Chip-Seq_ESCs_Mouse	1.20556272
65	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.19582049
66	* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.19523460
67	EWS_26573619_Chip-Seq_HEK293_Human	1.18941680
68	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.18884220
69	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.18690723
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.18455752
71	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.18361552
72	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.18315092
73	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.17793044
74	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17705768
75	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.17675490
76	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16317284
77	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.16313593
78	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.16313593
79	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.15935689
80	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.15904614
81	TCF4_22108803_ChIP-Seq_LS180_Human	1.14855587
82	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.14400941
83	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.14094758
84	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.12566058
85	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.11982242
86	AHR_22903824_ChIP-Seq_MCF-7_Human	1.11847696
87	* P53_22387025_ChIP-Seq_ESCs_Mouse	1.11838381
88	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.11780667
89	* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.10111876
90	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.10084967
91	P300_19829295_ChIP-Seq_ESCs_Human	1.09162627
92	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.09035181
93	STAT3_23295773_ChIP-Seq_U87_Human	1.08899549
94	RNF2_27304074_Chip-Seq_NSC_Mouse	1.08795356
95	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.08652299
96	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.08253501
97	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.07929835
98	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.06468053
99	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.06232946
100	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.06219991
101	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.06055055
102	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.05066382
103	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.04968869
104	* NANOG_19829295_ChIP-Seq_ESCs_Human	1.04746192
105	* SOX2_19829295_ChIP-Seq_ESCs_Human	1.04746192
106	KDM2B_26808549_Chip-Seq_REH_Human	1.04365864
107	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.04137074
108	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03131314
109	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.02933103
110	RUNX_20019798_ChIP-Seq_JUKART_Human	1.02916970
111	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.02604479
112	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.01352387
113	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99111764
114	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.98519384
115	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.97366920
116	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.96264944
117	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.94813747
118	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93539311
119	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.92926882
120	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.92610195
121	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.91953579
122	* TCF4_23295773_ChIP-Seq_U87_Human	0.91631750
123	ER_23166858_ChIP-Seq_MCF-7_Human	0.91429132
124	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.90974942
125	* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90460087
126	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.89833983
127	AR_25329375_ChIP-Seq_VCAP_Human	0.89785399
128	HTT_18923047_ChIP-ChIP_STHdh_Human	0.89298143
129	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.87402589
130	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.86434496
131	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.86234704
132	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.86211891
133	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.84602548
134	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.83903041
135	TP53_16413492_ChIP-PET_HCT116_Human	0.83082091
136	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.82734860
137	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.81733292
138	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.81052809
139	RUNX2_22187159_ChIP-Seq_PCA_Human	0.80914498
140	AR_19668381_ChIP-Seq_PC3_Human	0.80828908
141	TP53_18474530_ChIP-ChIP_U2OS_Human	0.80709475
142	* RING1B_27294783_Chip-Seq_ESCs_Mouse	0.80096558
143	* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.79843542
144	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.79478884

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.46867572
2	MP0002822_catalepsy	3.72539152
3	MP0004859_abnormal_synaptic_plasticity	3.60685904
4	MP0002139_abnormal_hepatobiliary_system	3.52973509
5	MP0003880_abnormal_central_pattern	3.42759044
6	MP0000920_abnormal_myelination	3.07433544
7	MP0003690_abnormal_glial_cell	3.00224821
8	MP0005360_urolithiasis	2.92938350
9	MP0004270_analgesia	2.92025963
10	MP0003787_abnormal_imprinting	2.89140074
11	MP0005085_abnormal_gallbladder_physiolo	2.86337641
12	MP0008875_abnormal_xenobiotic_pharmacok	2.74144254
13	MP0003329_amyloid_beta_deposits	2.53118330
14	MP0003635_abnormal_synaptic_transmissio	2.45542424
15	MP0002064_seizures	2.34838570
16	MP0009745_abnormal_behavioral_response	2.29237146
17	MP0005365_abnormal_bile_salt	2.28500276
18	MP0008877_abnormal_DNA_methylation	2.27529004
19	MP0001486_abnormal_startle_reflex	2.25726993
20	MP0002272_abnormal_nervous_system	2.11672145
21	MP0002063_abnormal_learning/memory/cond	1.98896745
22	MP0001986_abnormal_taste_sensitivity	1.97733520
23	MP0009840_abnormal_foam_cell	1.97562490
24	MP0004885_abnormal_endolymph	1.91777250
25	MP0000604_amyloidosis	1.91479636
26	MP0003724_increased_susceptibility_to	1.87291164
27	MP0003191_abnormal_cellular_cholesterol	1.81569531
28	MP0001968_abnormal_touch/_nociception	1.81433250
29	MP0002572_abnormal_emotion/affect_behav	1.76216504
30	MP0009046_muscle_twitch	1.72875822
31	MP0003195_calcinosis	1.71876685
32	MP0002734_abnormal_mechanical_nocicepti	1.69126726
33	MP0005174_abnormal_tail_pigmentation	1.68232904
34	MP0005423_abnormal_somatic_nervous	1.65136615
35	MP0001984_abnormal_olfaction	1.63357175
36	MP0003633_abnormal_nervous_system	1.57697387
37	MP0003252_abnormal_bile_duct	1.55996447
38	MP0001529_abnormal_vocalization	1.54423093
39	MP0003646_muscle_fatigue	1.54065330
40	MP0005058_abnormal_lysosome_morphology	1.53232924
41	MP0002638_abnormal_pupillary_reflex	1.51987982
42	MP0010329_abnormal_lipoprotein_level	1.51118147
43	MP0001905_abnormal_dopamine_level	1.49812312
44	MP0002876_abnormal_thyroid_physiology	1.49121832
45	MP0003806_abnormal_nucleotide_metabolis	1.49091292
46	MP0002102_abnormal_ear_morphology	1.47300139
47	MP0003634_abnormal_glial_cell	1.47188010
48	MP0002736_abnormal_nociception_after	1.46796086
49	MP0009780_abnormal_chondrocyte_physiolo	1.44040016
50	MP0001440_abnormal_grooming_behavior	1.43455117
51	MP0000427_abnormal_hair_cycle	1.43322071
52	MP0005671_abnormal_response_to	1.41989139
53	MP0006276_abnormal_autonomic_nervous	1.41296068
54	MP0005645_abnormal_hypothalamus_physiol	1.36691464
55	MP0003075_altered_response_to	1.35243920
56	MP0002229_neurodegeneration	1.34411514
57	MP0004142_abnormal_muscle_tone	1.34249940
58	MP0003631_nervous_system_phenotype	1.33687143
59	MP0001501_abnormal_sleep_pattern	1.32452488
60	MP0002118_abnormal_lipid_homeostasis	1.31856623
61	MP0001666_abnormal_nutrient_absorption	1.30836688
62	MP0001970_abnormal_pain_threshold	1.30096175
63	MP0004043_abnormal_pH_regulation	1.29177512
64	MP0004924_abnormal_behavior	1.29051791
65	MP0005386_behavior/neurological_phenoty	1.29051791
66	MP0002735_abnormal_chemical_nociception	1.28735398
67	MP0005083_abnormal_biliary_tract	1.26376526
68	MP0004742_abnormal_vestibular_system	1.25622660
69	MP0002090_abnormal_vision	1.24995441
70	MP0005409_darkened_coat_color	1.24595383
71	MP0004147_increased_porphyrin_level	1.24435624
72	MP0002067_abnormal_sensory_capabilities	1.23987250
73	MP0002733_abnormal_thermal_nociception	1.23068221
74	MP0005332_abnormal_amino_acid	1.22780926
75	MP0005646_abnormal_pituitary_gland	1.20961484
76	MP0005253_abnormal_eye_physiology	1.20587857
77	MP0000778_abnormal_nervous_system	1.20129727
78	MP0005584_abnormal_enzyme/coenzyme_acti	1.16308769
79	MP0003632_abnormal_nervous_system	1.15869054
80	MP0002928_abnormal_bile_duct	1.15122872
81	MP0008569_lethality_at_weaning	1.13782757
82	MP0008874_decreased_physiological_sensi	1.11722561
83	MP0000015_abnormal_ear_pigmentation	1.07779804
84	MP0002066_abnormal_motor_capabilities/c	1.06323764
85	MP0003879_abnormal_hair_cell	1.05153520
86	MP0010386_abnormal_urinary_bladder	1.04722466
87	MP0006072_abnormal_retinal_apoptosis	1.03694275
88	MP0006082_CNS_inflammation	1.03380630
89	MP0005535_abnormal_body_temperature	1.03172084
90	MP0000955_abnormal_spinal_cord	1.02698135
91	MP0001177_atelectasis	1.01906730
92	MP0002909_abnormal_adrenal_gland	1.00596579
93	MP0002557_abnormal_social/conspecific_i	1.00393197
94	MP0005551_abnormal_eye_electrophysiolog	1.00018252
95	MP0003172_abnormal_lysosome_physiology	0.97161928
96	MP0002882_abnormal_neuron_morphology	0.96185075
97	MP0004145_abnormal_muscle_electrophysio	0.93908719
98	MP0003656_abnormal_erythrocyte_physiolo	0.92870166
99	MP0001502_abnormal_circadian_rhythm	0.91962724
100	MP0001485_abnormal_pinna_reflex	0.91817930
101	MP0002653_abnormal_ependyma_morphology	0.91745514
102	MP0004484_altered_response_of	0.91530090
103	MP0003950_abnormal_plasma_membrane	0.88080328
104	MP0004215_abnormal_myocardial_fiber	0.85217382
105	MP0003045_fibrosis	0.84536841
106	MP0005167_abnormal_blood-brain_barrier	0.82558190
107	MP0003011_delayed_dark_adaptation	0.81605861
108	MP0003121_genomic_imprinting	0.81576262
109	MP0001800_abnormal_humoral_immune	0.81512140
110	MP0003137_abnormal_impulse_conducting	0.81270585
111	MP0004811_abnormal_neuron_physiology	0.81115687
112	MP0002095_abnormal_skin_pigmentation	0.79770361
113	MP0005451_abnormal_body_composition	0.79631159
114	MP0005310_abnormal_salivary_gland	0.79209888
115	MP0010678_abnormal_skin_adnexa	0.78250966
116	MP0009764_decreased_sensitivity_to	0.77728522
117	MP0003878_abnormal_ear_physiology	0.76157832
118	MP0005377_hearing/vestibular/ear_phenot	0.76157832
119	MP0000631_abnormal_neuroendocrine_gland	0.75044603
120	MP0002277_abnormal_respiratory_mucosa	0.73419833
121	MP0003868_abnormal_feces_composition	0.72933685
122	MP0000230_abnormal_systemic_arterial	0.72764425
123	MP0001963_abnormal_hearing_physiology	0.72403621
124	MP0004130_abnormal_muscle_cell	0.71925712
125	MP0008872_abnormal_physiological_respon	0.71672154
126	MP0001765_abnormal_ion_homeostasis	0.71322164
127	MP0005075_abnormal_melanosome_morpholog	0.70403612
128	MP0001835_abnormal_antigen_presentation	0.69274107
129	MP0000639_abnormal_adrenal_gland	0.68628372
130	MP0002069_abnormal_eating/drinking_beha	0.67202055
131	MP0002752_abnormal_somatic_nervous	0.67014084
132	MP0005171_absent_coat_pigmentation	0.66826875
133	MP0005410_abnormal_fertilization	0.66765247
134	MP0000609_abnormal_liver_physiology	0.65917629
135	MP0000747_muscle_weakness	0.65118820
136	MP0005166_decreased_susceptibility_to	0.63398770
137	MP0002184_abnormal_innervation	0.61731578
138	MP0004858_abnormal_nervous_system	0.60341604
139	MP0004085_abnormal_heartbeat	0.59407098
140	MP0002837_dystrophic_cardiac_calcinosis	0.58804101
141	MP0002295_abnormal_pulmonary_circulatio	0.57237606
142	MP0001299_abnormal_eye_distance/	0.55643477

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Neurofibrillary tangles (HP:0002185)	5.29763221
2	Myokymia (HP:0002411)	4.70488727
3	Degeneration of the lateral corticospinal tracts (HP:0002314)	4.19901271
4	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	4.19901271
5	Cerebral inclusion bodies (HP:0100314)	4.17098640
6	Progressive cerebellar ataxia (HP:0002073)	4.04402048
7	Febrile seizures (HP:0002373)	3.97916518
8	Intrahepatic cholestasis (HP:0001406)	3.76955877
9	Supranuclear gaze palsy (HP:0000605)	3.72154609
10	Focal motor seizures (HP:0011153)	3.67779103
11	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.65389499
12	Pancreatic cysts (HP:0001737)	3.61332856
13	Abnormality of the corticospinal tract (HP:0002492)	3.58433736
14	Congenital stationary night blindness (HP:0007642)	3.58177135
15	Deep venous thrombosis (HP:0002625)	3.54395334
16	Complement deficiency (HP:0004431)	3.51791683
17	Intention tremor (HP:0002080)	3.42130453
18	Gaze-evoked nystagmus (HP:0000640)	3.37875107
19	Genetic anticipation (HP:0003743)	3.35289661
20	Hyperlipoproteinemia (HP:0010980)	3.34630272
21	Xanthomatosis (HP:0000991)	3.31181981
22	Termporal pattern (HP:0011008)	3.27251363
23	Insidious onset (HP:0003587)	3.27251363
24	Pancreatic fibrosis (HP:0100732)	3.22008993
25	Stomach cancer (HP:0012126)	3.14992979
26	Hemiparesis (HP:0001269)	3.12606200
27	True hermaphroditism (HP:0010459)	3.10142708
28	Spastic gait (HP:0002064)	3.08753029
29	Molar tooth sign on MRI (HP:0002419)	3.08112762
30	Abnormality of midbrain morphology (HP:0002418)	3.08112762
31	Hemiplegia (HP:0002301)	3.06462449
32	Peripheral hypomyelination (HP:0007182)	2.97330400
33	Onion bulb formation (HP:0003383)	2.97014557
34	Stomatitis (HP:0010280)	2.96987632
35	Absent speech (HP:0001344)	2.91890523
36	Type II lissencephaly (HP:0007260)	2.89653325
37	Ankle clonus (HP:0011448)	2.89007972
38	Dysmetria (HP:0001310)	2.88567964
39	Abnormality of the renal cortex (HP:0011035)	2.87625098
40	Prolonged partial thromboplastin time (HP:0003645)	2.82458449
41	Action tremor (HP:0002345)	2.82279019
42	Nephronophthisis (HP:0000090)	2.81126272
43	Scanning speech (HP:0002168)	2.73956288
44	Axonal loss (HP:0003447)	2.69539448
45	Abnormality of the renal medulla (HP:0100957)	2.68281223
46	Focal seizures (HP:0007359)	2.67428301
47	Abnormality of binocular vision (HP:0011514)	2.66930680
48	Diplopia (HP:0000651)	2.66930680
49	Inability to walk (HP:0002540)	2.66447859
50	Abolished electroretinogram (ERG) (HP:0000550)	2.61601899
51	Medial flaring of the eyebrow (HP:0010747)	2.60932919
52	Hyperventilation (HP:0002883)	2.57022016
53	Absence seizures (HP:0002121)	2.48756789
54	Optic neuritis (HP:0100653)	2.48667636
55	Retrobulbar optic neuritis (HP:0100654)	2.48667636
56	Widely spaced teeth (HP:0000687)	2.48378459
57	Protruding tongue (HP:0010808)	2.46845866
58	Torticollis (HP:0000473)	2.46514916
59	Progressive inability to walk (HP:0002505)	2.46324744
60	Postural instability (HP:0002172)	2.39030375
61	Abnormal drinking behavior (HP:0030082)	2.38274205
62	Polydipsia (HP:0001959)	2.38274205
63	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.37941509
64	Limb dystonia (HP:0002451)	2.37062278
65	Sensory axonal neuropathy (HP:0003390)	2.36471410
66	Papilledema (HP:0001085)	2.36093056
67	Amyloidosis (HP:0011034)	2.35060820
68	Hypobetalipoproteinemia (HP:0003563)	2.34549629
69	Fair hair (HP:0002286)	2.31147868
70	Congenital sensorineural hearing impairment (HP:0008527)	2.30749437
71	Attenuation of retinal blood vessels (HP:0007843)	2.30402077
72	Cerebral hemorrhage (HP:0001342)	2.28734884
73	Neuronal loss in central nervous system (HP:0002529)	2.28451850
74	Systemic lupus erythematosus (HP:0002725)	2.27970463
75	Gait imbalance (HP:0002141)	2.27517291
76	Abnormal rod and cone electroretinograms (HP:0008323)	2.26999802
77	Clumsiness (HP:0002312)	2.26406286
78	Epileptic encephalopathy (HP:0200134)	2.25882947
79	Agitation (HP:0000713)	2.25277339
80	Epidermoid cyst (HP:0200040)	2.25152004
81	Fat malabsorption (HP:0002630)	2.23633600
82	Mutism (HP:0002300)	2.23021595
83	Large for gestational age (HP:0001520)	2.19415301
84	Ketosis (HP:0001946)	2.19126297
85	Craniofacial dystonia (HP:0012179)	2.16326461
86	Spastic tetraparesis (HP:0001285)	2.16178455
87	Glomerulonephritis (HP:0000099)	2.15947444
88	Focal dystonia (HP:0004373)	2.12912912
89	Parakeratosis (HP:0001036)	2.11830845
90	Drooling (HP:0002307)	2.11816986
91	Abnormality of complement system (HP:0005339)	2.11793949
92	Cystic liver disease (HP:0006706)	2.10287653
93	Blue irides (HP:0000635)	2.09749369
94	Metabolic alkalosis (HP:0200114)	2.09042306
95	Decreased central vision (HP:0007663)	2.08510871
96	Generalized hypopigmentation of hair (HP:0011358)	2.06847132
97	Generalized tonic-clonic seizures (HP:0002069)	2.06699675
98	Excessive salivation (HP:0003781)	2.06618978
99	Dysdiadochokinesis (HP:0002075)	2.06466913
100	Anxiety (HP:0000739)	2.06402022
101	Renal cortical cysts (HP:0000803)	2.06328391
102	Pheochromocytoma (HP:0002666)	2.06121637
103	Peripheral demyelination (HP:0011096)	2.05726706
104	Polyphagia (HP:0002591)	2.05317379
105	Chronic hepatic failure (HP:0100626)	2.05184380
106	Urinary urgency (HP:0000012)	2.05119369
107	Lower limb muscle weakness (HP:0007340)	2.04945369
108	Hypophosphatemic rickets (HP:0004912)	2.03793014
109	Atonic seizures (HP:0010819)	2.03407309
110	Clonus (HP:0002169)	2.02970989
111	Furrowed tongue (HP:0000221)	2.01247890
112	Orchitis (HP:0100796)	2.01056272
113	Lissencephaly (HP:0001339)	2.00523649
114	Impaired vibration sensation in the lower limbs (HP:0002166)	1.99490854
115	Congenital primary aphakia (HP:0007707)	1.97777542
116	Akinesia (HP:0002304)	1.97386288
117	Thyroiditis (HP:0100646)	1.96404306
118	Split foot (HP:0001839)	1.96026855
119	Abnormality of methionine metabolism (HP:0010901)	1.95980369
120	Hypochromic microcytic anemia (HP:0004840)	1.95905762
121	Urinary bladder sphincter dysfunction (HP:0002839)	1.93835987
122	Aplasia involving bones of the extremities (HP:0009825)	1.93197438
123	Aplasia involving bones of the upper limbs (HP:0009823)	1.93197438
124	Aplasia of the phalanges of the hand (HP:0009802)	1.93197438
125	Thickened helices (HP:0000391)	1.91502682
126	Retinal atrophy (HP:0001105)	1.91486664
127	Spastic paraparesis (HP:0002313)	1.91306371
128	Tubular atrophy (HP:0000092)	1.90967118
129	Slow saccadic eye movements (HP:0000514)	1.90755104
130	Keratoconus (HP:0000563)	1.89815190
131	Increased corneal curvature (HP:0100692)	1.89815190
132	Myositis (HP:0100614)	1.89116889
133	Polyuria (HP:0000103)	1.88954660
134	Hypokalemic alkalosis (HP:0001949)	1.88681833
135	Abnormality of glycine metabolism (HP:0010895)	1.88503012
136	Abnormality of serine family amino acid metabolism (HP:0010894)	1.88503012
137	Generalized myoclonic seizures (HP:0002123)	1.87641936
138	Steatorrhea (HP:0002570)	1.87172798
139	Nephrogenic diabetes insipidus (HP:0009806)	1.86173158
140	Conjugated hyperbilirubinemia (HP:0002908)	1.85514742
141	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.85035054
142	Decreased circulating renin level (HP:0003351)	1.84264351
143	Pendular nystagmus (HP:0012043)	1.83982288
144	Epileptiform EEG discharges (HP:0011182)	1.83855272
145	Increased circulating renin level (HP:0000848)	1.83619915
146	Abnormality of the periventricular white matter (HP:0002518)	1.83003806
147	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.82801255
148	Dialeptic seizures (HP:0011146)	1.82791439
149	Depression (HP:0000716)	1.82234673
150	Rigidity (HP:0002063)	1.82139937
151	Abnormality of liposaccharide metabolism (HP:0010968)	1.82067785
152	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.82067785
153	Abnormality of glycolipid metabolism (HP:0010969)	1.82067785
154	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.81735876
155	Morphological abnormality of the pyramidal tract (HP:0002062)	1.81212953
156	Paraparesis (HP:0002385)	1.80950418
157	Hammertoe (HP:0001765)	1.80530653
158	Hypomagnesemia (HP:0002917)	1.80452976
159	Abnormality of T cell number (HP:0011839)	1.79788419
160	Hyperammonemia (HP:0001987)	1.79522313
161	Dyskinesia (HP:0100660)	1.78880577
162	Broad-based gait (HP:0002136)	1.78626099
163	Abnormality of the common coagulation pathway (HP:0010990)	1.78050890
164	Megalencephaly (HP:0001355)	1.77802241
165	Hypothermia (HP:0002045)	1.77441071
166	Metaphyseal dysplasia (HP:0100255)	1.77252264
167	Abnormality of macular pigmentation (HP:0008002)	1.77192395
168	Bowel incontinence (HP:0002607)	1.77093445
169	Abnormal gallbladder physiology (HP:0012438)	1.76618388
170	Cholecystitis (HP:0001082)	1.76618388
171	Hyperglycinemia (HP:0002154)	1.76117217
172	Keratoconjunctivitis (HP:0001096)	1.76106889
173	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.75877086
174	Urinary incontinence (HP:0000020)	1.75794769
175	Confusion (HP:0001289)	1.75249398
176	Truncal ataxia (HP:0002078)	1.74448942
177	Elevated erythrocyte sedimentation rate (HP:0003565)	1.74012453
178	Abnormal eating behavior (HP:0100738)	1.73341603
179	EEG with generalized epileptiform discharges (HP:0011198)	1.71987797
180	Congenital, generalized hypertrichosis (HP:0004540)	1.69526601
181	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.69184019
182	Hypsarrhythmia (HP:0002521)	1.69040007
183	T lymphocytopenia (HP:0005403)	1.68812340
184	Congenital hepatic fibrosis (HP:0002612)	1.67142035
185	Visual hallucinations (HP:0002367)	1.67075021

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.39755962
2	EPHA4	4.30351013
3	STK39	4.15650328
4	OXSR1	2.97726671
5	NTRK3	2.44864355
6	TAOK3	2.42092566
7	ACVR1B	2.23431840
8	EPHB1	2.21523112
9	NTRK1	2.14864022
10	MAP3K9	2.14754724
11	ADRBK2	2.12333328
12	TXK	2.10955865
13	BMPR1B	2.10114282
14	PKN1	1.95350929
15	KSR2	1.89363664
16	RIPK4	1.87067545
17	WNK3	1.86523216
18	FGFR2	1.85864286
19	TNIK	1.80357000
20	MAP3K13	1.74457438
21	MAP4K2	1.66596529
22	DAPK2	1.61653761
23	PAK6	1.61527787
24	CASK	1.44864267
25	MARK1	1.43908924
26	MAPK15	1.41845710
27	SGK494	1.40416158
28	SGK223	1.40416158
29	WNK4	1.37811426
30	MAP3K2	1.36146211
31	SGK2	1.34604150
32	MAP3K4	1.34087562
33	PRPF4B	1.32513263
34	GRK1	1.31814756
35	WNK1	1.27030082
36	CAMK2B	1.24927864
37	CDK5	1.22491480
38	NEK6	1.21606606
39	MAP2K4	1.18293546
40	TNK2	1.17600089
41	PHKG1	1.17245505
42	PHKG2	1.17245505
43	PDPK1	1.16230283
44	MAPKAPK5	1.12532278
45	FES	1.12365599
46	BCR	1.11956115
47	MINK1	1.11676291
48	FGR	1.07449240
49	TYRO3	1.05491966
50	MET	1.03572448
51	PLK2	1.03256975
52	NTRK2	1.02821029
53	UHMK1	1.01208921
54	CAMKK1	0.98513018
55	CAMK2A	0.96392566
56	ADRBK1	0.95591722
57	CAMK2D	0.94304127
58	PRKCH	0.94275052
59	NUAK1	0.93582862
60	PDK1	0.92196084
61	CSNK1G2	0.92029912
62	ARAF	0.90755737
63	PINK1	0.90417340
64	CDK19	0.89114654
65	PAK3	0.88908765
66	CAMK2G	0.87744490
67	SYK	0.87440774
68	PBK	0.86452367
69	MAP2K7	0.85754602
70	PRKCQ	0.84542947
71	ICK	0.83412821
72	NLK	0.82174477
73	IRAK2	0.82136029
74	CSNK1A1L	0.81545980
75	BLK	0.79570518
76	MAPK7	0.78066322
77	BMPR2	0.77735097
78	CSNK1G3	0.77572447
79	TEC	0.77371419
80	GRK6	0.77321264
81	ITK	0.77120872
82	CAMK1G	0.76930038
83	PRKD3	0.76521172
84	JAK1	0.76258474
85	EPHA3	0.76117158
86	AKT3	0.76075078
87	ROCK2	0.75551363
88	OBSCN	0.75110300
89	MARK2	0.74823578
90	RET	0.74679484
91	BCKDK	0.74234213
92	IKBKE	0.74089072
93	MAPK12	0.74083972
94	STK38	0.73451749
95	PRKD1	0.72776282
96	PDK2	0.72601285
97	MAP3K7	0.70537340
98	STK38L	0.70522106
99	MAP4K1	0.70209314
100	DYRK1A	0.68575092
101	GRK5	0.67003606
102	FYN	0.65309799
103	PNCK	0.65180692
104	CSNK1G1	0.63360008
105	PIK3CA	0.62995532
106	PRKCE	0.61522211
107	MAP3K1	0.61419480
108	STK11	0.60913387
109	LMTK2	0.60269956
110	MAP2K6	0.59941733
111	PRKCG	0.59886034
112	INSRR	0.59493763
113	GRK7	0.58684905
114	CAMK4	0.57954761
115	PRKCZ	0.57917178
116	SGK3	0.57274209
117	PIK3CG	0.57018110
118	ERBB4	0.56701301
119	LYN	0.56183913
120	CDK14	0.55794490
121	IRAK1	0.55590050
122	KIT	0.55251927
123	SIK1	0.53600551
124	PTK2B	0.52632574
125	MAPK13	0.52523109
126	CDK15	0.51518540
127	SGK1	0.50969273
128	KSR1	0.50373274
129	LCK	0.49325746
130	CAMK1	0.48510514
131	JAK2	0.48487888
132	PRKACA	0.47788405
133	CSK	0.47785729
134	CDK18	0.46996852
135	IKBKB	0.44765177
136	CSF1R	0.43409496
137	ZAK	0.42961413
138	MARK3	0.42126318
139	CAMKK2	0.41825364
140	PRKG1	0.41008862
141	ERN1	0.40832822
142	TGFBR1	0.40467688
143	TLK1	0.40331619
144	SIK2	0.40280583
145	CLK1	0.40263066

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	3.59924882
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.58098615
3	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.25905215
4	Steroid biosynthesis_Homo sapiens_hsa00100	2.12356159
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.05286710
6	Phototransduction_Homo sapiens_hsa04744	2.05224894
7	Fatty acid elongation_Homo sapiens_hsa00062	2.03657996
8	Butanoate metabolism_Homo sapiens_hsa00650	2.01445491
9	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.76718638
10	Linoleic acid metabolism_Homo sapiens_hsa00591	1.75246687
11	Sulfur metabolism_Homo sapiens_hsa00920	1.72348753
12	Arginine biosynthesis_Homo sapiens_hsa00220	1.69908213
13	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.68173714
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.60535524
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.59946949
16	GABAergic synapse_Homo sapiens_hsa04727	1.51248464
17	Histidine metabolism_Homo sapiens_hsa00340	1.50570175
18	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.45751398
19	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.44012725
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.41491840
21	Olfactory transduction_Homo sapiens_hsa04740	1.39060194
22	Glutamatergic synapse_Homo sapiens_hsa04724	1.37437708
23	Complement and coagulation cascades_Homo sapiens_hsa04610	1.33431666
24	Bile secretion_Homo sapiens_hsa04976	1.28814791
25	Morphine addiction_Homo sapiens_hsa05032	1.28541542
26	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.26859515
27	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.26817014
28	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.25232701
29	Nicotine addiction_Homo sapiens_hsa05033	1.23246241
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.21765646
31	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.21530758
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.21090637
33	Fatty acid metabolism_Homo sapiens_hsa01212	1.20810025
34	Circadian entrainment_Homo sapiens_hsa04713	1.20572637
35	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.18978502
36	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.15614492
37	Propanoate metabolism_Homo sapiens_hsa00640	1.13998936
38	Fatty acid degradation_Homo sapiens_hsa00071	1.13927792
39	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.12911700
40	Cocaine addiction_Homo sapiens_hsa05030	1.12647250
41	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.11328004
42	Regulation of autophagy_Homo sapiens_hsa04140	1.10402260
43	Salivary secretion_Homo sapiens_hsa04970	1.09335927
44	Chemical carcinogenesis_Homo sapiens_hsa05204	1.08583165
45	Peroxisome_Homo sapiens_hsa04146	1.08002553
46	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.04192541
47	Amphetamine addiction_Homo sapiens_hsa05031	1.01580316
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.01385555
49	PPAR signaling pathway_Homo sapiens_hsa03320	1.00772064
50	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.00723625
51	ABC transporters_Homo sapiens_hsa02010	1.00195249
52	beta-Alanine metabolism_Homo sapiens_hsa00410	0.97013554
53	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.96432874
54	Renin secretion_Homo sapiens_hsa04924	0.94684561
55	Circadian rhythm_Homo sapiens_hsa04710	0.94070107
56	Dopaminergic synapse_Homo sapiens_hsa04728	0.93051849
57	Prion diseases_Homo sapiens_hsa05020	0.89964413
58	Cholinergic synapse_Homo sapiens_hsa04725	0.88797920
59	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.88625502
60	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.87999134
61	Primary immunodeficiency_Homo sapiens_hsa05340	0.87965112
62	Type I diabetes mellitus_Homo sapiens_hsa04940	0.87634608
63	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.85780644
64	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.85725674
65	Long-term potentiation_Homo sapiens_hsa04720	0.85568187
66	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.83321497
67	Gastric acid secretion_Homo sapiens_hsa04971	0.82879229
68	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.82114345
69	Serotonergic synapse_Homo sapiens_hsa04726	0.80166370
70	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.78859868
71	Insulin secretion_Homo sapiens_hsa04911	0.78473923
72	Graft-versus-host disease_Homo sapiens_hsa05332	0.78262616
73	Long-term depression_Homo sapiens_hsa04730	0.77155812
74	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.75255071
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.74674379
76	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.74377793
77	Retinol metabolism_Homo sapiens_hsa00830	0.74249149
78	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.74182468
79	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.73510112
80	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.70718863
81	Axon guidance_Homo sapiens_hsa04360	0.70614080
82	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.69374255
83	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.66409114
84	Cardiac muscle contraction_Homo sapiens_hsa04260	0.65926625
85	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.64923683
86	Allograft rejection_Homo sapiens_hsa05330	0.64672477
87	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.64655094
88	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64566986
89	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.64284913
90	Chemokine signaling pathway_Homo sapiens_hsa04062	0.63450309
91	Arginine and proline metabolism_Homo sapiens_hsa00330	0.63340427
92	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.62277968
93	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.62222977
94	Caffeine metabolism_Homo sapiens_hsa00232	0.61324560
95	Lysosome_Homo sapiens_hsa04142	0.59725607
96	Tyrosine metabolism_Homo sapiens_hsa00350	0.58964068
97	Calcium signaling pathway_Homo sapiens_hsa04020	0.58786860
98	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.58472592
99	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.58057734
100	Phenylalanine metabolism_Homo sapiens_hsa00360	0.57861448
101	cAMP signaling pathway_Homo sapiens_hsa04024	0.57097909
102	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.55540630
103	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.55097984
104	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.54777094
105	Pyruvate metabolism_Homo sapiens_hsa00620	0.54726709
106	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.54430082
107	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.53598394
108	Ras signaling pathway_Homo sapiens_hsa04014	0.53197389
109	MAPK signaling pathway_Homo sapiens_hsa04010	0.52297792
110	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.51568137
111	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.50867823
112	Taste transduction_Homo sapiens_hsa04742	0.50364635
113	Mineral absorption_Homo sapiens_hsa04978	0.50188891
114	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.49859687
115	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.49146909
116	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.48970835
117	Rheumatoid arthritis_Homo sapiens_hsa05323	0.48946601
118	Vibrio cholerae infection_Homo sapiens_hsa05110	0.48431210
119	GnRH signaling pathway_Homo sapiens_hsa04912	0.48417462
120	Type II diabetes mellitus_Homo sapiens_hsa04930	0.48261434
121	Gap junction_Homo sapiens_hsa04540	0.47885208
122	Sphingolipid metabolism_Homo sapiens_hsa00600	0.47834919
123	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.47216231
124	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.47121432
125	Fat digestion and absorption_Homo sapiens_hsa04975	0.45780511
126	Tuberculosis_Homo sapiens_hsa05152	0.45366573
127	Osteoclast differentiation_Homo sapiens_hsa04380	0.45198698
128	Asthma_Homo sapiens_hsa05310	0.45129515
129	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.45086763
130	African trypanosomiasis_Homo sapiens_hsa05143	0.44824141
131	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.42498264
132	Pancreatic secretion_Homo sapiens_hsa04972	0.42254278
133	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.42197675
134	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.41955528
135	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.41213342
136	Platelet activation_Homo sapiens_hsa04611	0.41035640
137	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.40320054
138	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.40279194

GPR155

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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