GPR156

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: G protein-coupled receptors (GPCRs) are a large superfamily of cell surface receptors characterized by 7 helical transmembrane domains, together with N-terminal extracellular and C-terminal intracellular domains. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glial cell proliferation (GO:0014009)9.86514546
2regulation of hippo signaling (GO:0035330)8.45971577
3cornea development in camera-type eye (GO:0061303)8.16100162
4neuron cell-cell adhesion (GO:0007158)6.49515310
5synaptic vesicle endocytosis (GO:0048488)6.47452240
6serotonin receptor signaling pathway (GO:0007210)6.35694975
7cerebral cortex radially oriented cell migration (GO:0021799)6.02860783
8negative regulation of glial cell proliferation (GO:0060253)5.81264275
9histone H3-K4 trimethylation (GO:0080182)5.76129737
10regulation of chromatin binding (GO:0035561)5.64135534
11regulation of timing of cell differentiation (GO:0048505)5.33301279
12limb bud formation (GO:0060174)5.31187445
13presynaptic membrane assembly (GO:0097105)5.27748523
14central nervous system projection neuron axonogenesis (GO:0021952)5.25798696
15hindbrain development (GO:0030902)5.17455354
16proximal/distal pattern formation (GO:0009954)5.06195080
17neuronal stem cell maintenance (GO:0097150)5.05609188
18pyrimidine nucleobase catabolic process (GO:0006208)5.01004263
19potassium ion export (GO:0071435)4.96135968
20postsynaptic membrane organization (GO:0001941)4.94557669
21radial glial cell differentiation (GO:0060019)4.90514307
22regulation of development, heterochronic (GO:0040034)4.89240212
23microtubule depolymerization (GO:0007019)4.80100440
24vocalization behavior (GO:0071625)4.78812460
25sympathetic nervous system development (GO:0048485)4.36182111
26axonal fasciculation (GO:0007413)4.35261631
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.34888151
28mitotic chromosome condensation (GO:0007076)4.28405385
29spinal cord development (GO:0021510)4.28305641
30presynaptic membrane organization (GO:0097090)4.28135743
31lung secretory cell differentiation (GO:0061140)4.24495789
32chromosome condensation (GO:0030261)4.17079602
33lateral sprouting from an epithelium (GO:0060601)4.12732304
34membrane repolarization (GO:0086009)4.12468056
35negative regulation of transcription regulatory region DNA binding (GO:2000678)4.08720261
36cell migration in hindbrain (GO:0021535)4.06897422
37nuclear pore complex assembly (GO:0051292)4.01921860
38regulation of DNA endoreduplication (GO:0032875)4.01261139
39axonemal dynein complex assembly (GO:0070286)4.00872371
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.97435625
41spermatid nucleus differentiation (GO:0007289)3.95566492
42glial cell differentiation (GO:0010001)3.90441271
43microtubule polymerization or depolymerization (GO:0031109)3.88119298
44pore complex assembly (GO:0046931)3.87568206
45central nervous system neuron axonogenesis (GO:0021955)3.85305453
46DNA packaging (GO:0006323)3.83345663
47dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.82947805
48hippocampus development (GO:0021766)3.82856214
49nucleobase catabolic process (GO:0046113)3.81374712
50positive regulation of neuroblast proliferation (GO:0002052)3.78825537
51cilium or flagellum-dependent cell motility (GO:0001539)3.78406195
52somite development (GO:0061053)3.77384404
53neuron recognition (GO:0008038)3.69400272
54piRNA metabolic process (GO:0034587)3.68682818
55cerebral cortex cell migration (GO:0021795)3.67788449
56regulation of histone H3-K27 methylation (GO:0061085)3.64046498
57cardiac ventricle formation (GO:0003211)3.63040239
58nonmotile primary cilium assembly (GO:0035058)3.60532366
59regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.57814904
60binding of sperm to zona pellucida (GO:0007339)3.54727680
61mitotic metaphase plate congression (GO:0007080)3.53582901
62axon extension (GO:0048675)3.51667884
63negative regulation of stem cell proliferation (GO:2000647)3.48404489
64acrosome reaction (GO:0007340)3.45130506
65oligodendrocyte differentiation (GO:0048709)3.44920835
66regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.43313843
67regulation of respiratory system process (GO:0044065)3.37040378
68artery development (GO:0060840)3.33576857
69sister chromatid segregation (GO:0000819)3.33305086
70centriole replication (GO:0007099)3.32782051
71protein localization to chromosome, centromeric region (GO:0071459)3.32733120
72cardiac chamber formation (GO:0003207)3.32030165
73positive regulation of male gonad development (GO:2000020)3.31043506
74embryonic digestive tract morphogenesis (GO:0048557)3.30393619
75regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.29790441
76microtubule severing (GO:0051013)3.29315624
77protein localization to kinetochore (GO:0034501)3.26359535
78regulation of centriole replication (GO:0046599)3.26185321
79dorsal/ventral axis specification (GO:0009950)3.25921551
80positive regulation of synapse assembly (GO:0051965)3.25844416
81cell proliferation in forebrain (GO:0021846)3.25537806
82neural crest cell development (GO:0014032)3.24156989
83cranial nerve morphogenesis (GO:0021602)3.24124347
84motile cilium assembly (GO:0044458)3.23637444
85histone H4-K5 acetylation (GO:0043981)3.22086223
86histone H4-K8 acetylation (GO:0043982)3.22086223
87synapsis (GO:0007129)3.21902006
88cranial suture morphogenesis (GO:0060363)3.19983164
89negative regulation of keratinocyte proliferation (GO:0010839)3.18548502
90mitotic sister chromatid segregation (GO:0000070)3.18515067
91kidney morphogenesis (GO:0060993)3.17558320
92lens morphogenesis in camera-type eye (GO:0002089)3.17187827
93negative regulation of dendrite development (GO:2000171)3.16035628
94facial nerve structural organization (GO:0021612)3.14640356
95inner ear receptor stereocilium organization (GO:0060122)3.13412147
96sperm-egg recognition (GO:0035036)3.09021180
97negative regulation of oligodendrocyte differentiation (GO:0048715)3.08751876
98multicellular organism reproduction (GO:0032504)3.08585396
99metaphase plate congression (GO:0051310)3.07563705
100neuron projection extension (GO:1990138)3.05324473
101negative regulation of axon extension involved in axon guidance (GO:0048843)3.04370098
102regulation of Rac protein signal transduction (GO:0035020)3.04345016
103neuron fate determination (GO:0048664)3.03334156
104regulation of acrosome reaction (GO:0060046)3.03254758
105cilium movement (GO:0003341)3.02748324
106positive regulation of chromosome segregation (GO:0051984)3.02738341
107DNA methylation involved in gamete generation (GO:0043046)3.02256025
108regulation of female gonad development (GO:2000194)3.02166315
109positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.01477888
110eyelid development in camera-type eye (GO:0061029)3.00355303
111regulation of glial cell proliferation (GO:0060251)3.00251799
112positive regulation of granulocyte differentiation (GO:0030854)2.97473374
113attachment of spindle microtubules to kinetochore (GO:0008608)2.96277207
114regulation of meiosis I (GO:0060631)2.93891212
115apical protein localization (GO:0045176)2.93790991
116regulation of spindle organization (GO:0090224)2.93284639
117cerebral cortex neuron differentiation (GO:0021895)2.91156157
118dendrite morphogenesis (GO:0048813)2.90198350
119synaptic vesicle transport (GO:0048489)2.88786741
120establishment of synaptic vesicle localization (GO:0097480)2.88786741
121astrocyte differentiation (GO:0048708)2.87163949
122negative regulation of axon extension (GO:0030517)2.85899733
123peptidyl-lysine trimethylation (GO:0018023)2.85537515
124histone H3-K36 demethylation (GO:0070544)2.85296661
125membrane tubulation (GO:0097320)2.85287978
126regulation of dendritic spine morphogenesis (GO:0061001)2.83242154
127DNA unwinding involved in DNA replication (GO:0006268)2.83141461
128meiotic cell cycle (GO:0051321)2.82910436
129mitotic sister chromatid cohesion (GO:0007064)2.82805776
130lung morphogenesis (GO:0060425)2.82357037
131nucleus organization (GO:0006997)2.81967396
132chromosome organization involved in meiosis (GO:0070192)2.81836498
133notochord development (GO:0030903)2.79952501
134positive regulation of histone H3-K4 methylation (GO:0051571)2.79628695
135centriole assembly (GO:0098534)2.79076752
136epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.77674114
137melanosome transport (GO:0032402)2.76149294
138dendritic spine morphogenesis (GO:0060997)2.75915389
139lens fiber cell differentiation (GO:0070306)2.75420303
140nuclear pore organization (GO:0006999)2.74459384
141spermatid development (GO:0007286)2.73944909
142C4-dicarboxylate transport (GO:0015740)2.73890178
143epithelial cilium movement (GO:0003351)2.73842131
144sperm motility (GO:0030317)2.72691142
145regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.72615155
146negative regulation of glycogen metabolic process (GO:0070874)2.72504183
147telencephalon cell migration (GO:0022029)2.72101340
148histone exchange (GO:0043486)2.71885547
149gene silencing by RNA (GO:0031047)2.71817821
150regulation of mitotic spindle organization (GO:0060236)2.71249326
151planar cell polarity pathway involved in neural tube closure (GO:0090179)2.68453230
152regulation of centrosome cycle (GO:0046605)2.68411500
153male meiosis I (GO:0007141)2.68144209
154regulation of cilium movement (GO:0003352)2.67091336
155embryonic body morphogenesis (GO:0010172)2.64885546
156positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.64800106
157positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.64800106
158positive regulation of mitotic sister chromatid separation (GO:1901970)2.64800106
159regulation of histone H3-K9 methylation (GO:0051570)2.63978007
160protein complex localization (GO:0031503)2.63460850
161olfactory bulb development (GO:0021772)2.61925860
162male meiosis (GO:0007140)2.61357263
163positive regulation of cell cycle G2/M phase transition (GO:1902751)2.61339285
164positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.61339285
165paraxial mesoderm development (GO:0048339)2.60302722
166ventricular cardiac muscle cell development (GO:0055015)2.60051331
167layer formation in cerebral cortex (GO:0021819)2.59945738
168negative regulation of inclusion body assembly (GO:0090084)2.59440378
169CENP-A containing nucleosome assembly (GO:0034080)2.58345458
170kinetochore organization (GO:0051383)2.56686102
171positive regulation of dendritic spine morphogenesis (GO:0061003)2.56524695
172sister chromatid cohesion (GO:0007062)2.55349969
173regulation of keratinocyte proliferation (GO:0010837)2.54514001
174regulation of chromosome segregation (GO:0051983)2.53934713
175establishment or maintenance of monopolar cell polarity (GO:0061339)2.53830504
176establishment of monopolar cell polarity (GO:0061162)2.53830504
177negative regulation of histone methylation (GO:0031061)2.53163138
178negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.53151033
179asymmetric protein localization (GO:0008105)2.52723139
180gonadal mesoderm development (GO:0007506)2.52528853
181mitotic nuclear envelope disassembly (GO:0007077)2.52380876
182regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.51986146
183nuclear envelope disassembly (GO:0051081)2.47820619
184membrane disassembly (GO:0030397)2.47820619
185chromatin remodeling at centromere (GO:0031055)2.46898519
186synaptonemal complex assembly (GO:0007130)2.46505692
187opioid receptor signaling pathway (GO:0038003)2.46277417
188protein localization to microtubule cytoskeleton (GO:0072698)2.46145762

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.55855490
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.47011383
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.63930415
4EZH2_22144423_ChIP-Seq_EOC_Human4.40607553
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.57008822
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.54355379
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.01487814
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.82538882
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.75261989
10IGF1R_20145208_ChIP-Seq_DFB_Human2.68161679
11ERG_21242973_ChIP-ChIP_JURKAT_Human2.57144095
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.57079219
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53815771
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.52366379
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.46842170
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45188319
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45188319
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44363128
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.42344044
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.35051925
21TAF15_26573619_Chip-Seq_HEK293_Human2.30503354
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.29842970
23* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22719878
24* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.21038285
25* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.13844314
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.13062447
27CBX2_27304074_Chip-Seq_ESCs_Mouse2.10629842
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.08969080
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.08548385
30REST_21632747_ChIP-Seq_MESCs_Mouse2.07579515
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.06655519
32* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98664633
33AR_21909140_ChIP-Seq_LNCAP_Human1.97894078
34GBX2_23144817_ChIP-Seq_PC3_Human1.97327688
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.95914327
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.89840321
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88251000
38* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87276026
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87089829
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86756610
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.85813580
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79129585
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78045466
44ELK4_26923725_Chip-Seq_MESODERM_Mouse1.71453524
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69140257
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69047325
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.68019103
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.67798693
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67354289
50AR_21572438_ChIP-Seq_LNCaP_Human1.65221856
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.64615497
52* SMAD4_21799915_ChIP-Seq_A2780_Human1.58221557
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.54473737
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.52413111
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.49363324
56RNF2_27304074_Chip-Seq_NSC_Mouse1.48850466
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.48626864
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46696600
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.45354981
60P300_19829295_ChIP-Seq_ESCs_Human1.41137666
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40615512
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39884034
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39884034
64DROSHA_22980978_ChIP-Seq_HELA_Human1.38509221
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.36944105
66AR_25329375_ChIP-Seq_VCAP_Human1.36723435
67TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.36080108
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.35977464
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.35692567
70PKCTHETA_26484144_Chip-Seq_BREAST_Human1.34608482
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33729450
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32466272
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32398611
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.31586661
75EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28758893
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25443068
77ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25233413
78YAP1_20516196_ChIP-Seq_MESCs_Mouse1.24151297
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22428154
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21269112
81RUNX2_22187159_ChIP-Seq_PCA_Human1.21045905
82OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20512844
83AR_19668381_ChIP-Seq_PC3_Human1.18210769
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17688021
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16874567
86RARB_27405468_Chip-Seq_BRAIN_Mouse1.16685326
87TP53_18474530_ChIP-ChIP_U2OS_Human1.16598472
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16279579
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15533504
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13924099
91* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13757051
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13414643
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12664044
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12579112
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12318748
96CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11768316
97OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11370467
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.10824156
99WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09127745
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07663758
101* STAT3_23295773_ChIP-Seq_U87_Human1.07015823
102KDM2B_26808549_Chip-Seq_K562_Human1.06413469
103* SOX9_26525672_Chip-Seq_HEART_Mouse1.05667028
104BCAT_22108803_ChIP-Seq_LS180_Human1.05501946
105* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05493415
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05385842
107EP300_21415370_ChIP-Seq_HL-1_Mouse1.05282387
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05103086
109TBL1_22424771_ChIP-Seq_293T_Human1.04947208
110* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04222746
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03856945
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03558919
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03519100
114* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02469316
115FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02413977
116NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99348274
117TCF4_18268006_ChIP-ChIP_LS174T_Human0.99017231
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98803922
119AHR_22903824_ChIP-Seq_MCF-7_Human0.98699461
120TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98648243
121TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97431131
122STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97268459
123RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95307418
124ISL1_27105846_Chip-Seq_CPCs_Mouse0.94852182
125SMAD4_21741376_ChIP-Seq_EPCs_Human0.94670779
126ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94371587
127POU5F1_16518401_ChIP-PET_MESCs_Mouse0.93218641
128NANOG_18555785_Chip-Seq_ESCs_Mouse0.92786298
129TCF4_23295773_ChIP-Seq_U87_Human0.92404693
130IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92205797
131CBP_20019798_ChIP-Seq_JUKART_Human0.92205797
132CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91515408
133EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90565985
134HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.90454024
135TP53_20018659_ChIP-ChIP_R1E_Mouse0.89837830
136KDM2B_26808549_Chip-Seq_REH_Human0.89812566
137SMAD_19615063_ChIP-ChIP_OVARY_Human0.89805639
138JUN_21703547_ChIP-Seq_K562_Human0.88979140
139FUS_26573619_Chip-Seq_HEK293_Human0.87979480
140SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87242933
141PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86550269
142LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86537338
143EWS_26573619_Chip-Seq_HEK293_Human0.86151863
144SMAD4_21741376_ChIP-Seq_HESCs_Human0.85973083
145ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85147747
146VDR_22108803_ChIP-Seq_LS180_Human0.83143933
147SOX9_24532713_ChIP-Seq_HFSC_Mouse0.82478887
148NFYB_21822215_ChIP-Seq_K562_Human0.82210133
149WDR5_24793694_ChIP-Seq_LNCAP_Human0.80671387
150ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80391854

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode6.59666275
2MP0008789_abnormal_olfactory_epithelium4.03420516
3MP0002837_dystrophic_cardiac_calcinosis3.93048364
4MP0005394_taste/olfaction_phenotype3.55234273
5MP0005499_abnormal_olfactory_system3.55234273
6MP0001984_abnormal_olfaction3.45899207
7MP0003787_abnormal_imprinting3.43130506
8MP0005257_abnormal_intraocular_pressure3.38699831
9MP0003718_maternal_effect3.08298826
10MP0000569_abnormal_digit_pigmentation3.02481971
11MP0002638_abnormal_pupillary_reflex2.97028646
12MP0000778_abnormal_nervous_system2.96477162
13MP0010030_abnormal_orbit_morphology2.85320734
14MP0002938_white_spotting2.73867876
15MP0005623_abnormal_meninges_morphology2.68993280
16MP0003705_abnormal_hypodermis_morpholog2.66808331
17MP0000566_synostosis2.65484448
18MP0000537_abnormal_urethra_morphology2.51881419
19MP0008057_abnormal_DNA_replication2.46948722
20MP0001849_ear_inflammation2.24142034
21MP0005410_abnormal_fertilization2.16258049
22MP0010094_abnormal_chromosome_stability2.09097811
23MP0003121_genomic_imprinting2.07828982
24MP0002234_abnormal_pharynx_morphology2.06094307
25MP0002928_abnormal_bile_duct2.03456179
26MP0003077_abnormal_cell_cycle1.90838218
27MP0001929_abnormal_gametogenesis1.87155055
28MP0006276_abnormal_autonomic_nervous1.86290952
29MP0000428_abnormal_craniofacial_morphol1.85077985
30MP0005174_abnormal_tail_pigmentation1.83590917
31MP0003880_abnormal_central_pattern1.81341859
32MP0004270_analgesia1.79367477
33MP0002184_abnormal_innervation1.74512804
34MP0003111_abnormal_nucleus_morphology1.73955060
35MP0004859_abnormal_synaptic_plasticity1.71852692
36MP0003755_abnormal_palate_morphology1.69746908
37MP0010368_abnormal_lymphatic_system1.67742215
38MP0002233_abnormal_nose_morphology1.66914315
39MP0001529_abnormal_vocalization1.65762226
40MP0003693_abnormal_embryo_hatching1.65123451
41MP0000015_abnormal_ear_pigmentation1.61654470
42MP0003385_abnormal_body_wall1.61451515
43MP0003890_abnormal_embryonic-extraembry1.61168965
44MP0003698_abnormal_male_reproductive1.59129133
45MP0008877_abnormal_DNA_methylation1.57994182
46MP0003938_abnormal_ear_development1.55447044
47MP0010307_abnormal_tumor_latency1.54581713
48MP0010352_gastrointestinal_tract_polyps1.54105504
49MP0003635_abnormal_synaptic_transmissio1.49445370
50MP0008932_abnormal_embryonic_tissue1.48979809
51MP0002210_abnormal_sex_determination1.48226433
52MP0008058_abnormal_DNA_repair1.48043885
53MP0001486_abnormal_startle_reflex1.47951031
54MP0002751_abnormal_autonomic_nervous1.44171895
55MP0002063_abnormal_learning/memory/cond1.43462590
56MP0002177_abnormal_outer_ear1.40766230
57MP0005248_abnormal_Harderian_gland1.37389332
58MP0002735_abnormal_chemical_nociception1.36582261
59MP0000049_abnormal_middle_ear1.36084117
60MP0001177_atelectasis1.36045754
61MP0004957_abnormal_blastocyst_morpholog1.35991164
62MP0000516_abnormal_urinary_system1.35015095
63MP0005367_renal/urinary_system_phenotyp1.35015095
64MP0002733_abnormal_thermal_nociception1.32332759
65MP0002092_abnormal_eye_morphology1.32181009
66MP0001968_abnormal_touch/_nociception1.31334126
67MP0004233_abnormal_muscle_weight1.26930048
68MP0003315_abnormal_perineum_morphology1.26517686
69MP0003950_abnormal_plasma_membrane1.25260669
70MP0005646_abnormal_pituitary_gland1.24857933
71MP0005187_abnormal_penis_morphology1.24036641
72MP0000631_abnormal_neuroendocrine_gland1.23981389
73MP0001348_abnormal_lacrimal_gland1.23031173
74MP0002161_abnormal_fertility/fecundity1.17812893
75MP0002572_abnormal_emotion/affect_behav1.17532296
76MP0002084_abnormal_developmental_patter1.17440703
77MP0002734_abnormal_mechanical_nocicepti1.16894657
78MP0004811_abnormal_neuron_physiology1.15493057
79MP0002557_abnormal_social/conspecific_i1.14942709
80MP0000534_abnormal_ureter_morphology1.14821994
81MP0001730_embryonic_growth_arrest1.14168762
82MP0001145_abnormal_male_reproductive1.13703947
83MP0000653_abnormal_sex_gland1.13071686
84MP0003172_abnormal_lysosome_physiology1.13069811
85MP0002653_abnormal_ependyma_morphology1.12913327
86MP0003119_abnormal_digestive_system1.12743336
87MP0008007_abnormal_cellular_replicative1.12479804
88MP0003937_abnormal_limbs/digits/tail_de1.11134871
89MP0000733_abnormal_muscle_development1.10947213
90MP0005075_abnormal_melanosome_morpholog1.08720974
91MP0002085_abnormal_embryonic_tissue1.08244254
92MP0003941_abnormal_skin_development1.07748276
93MP0003329_amyloid_beta_deposits1.07639029
94MP0004885_abnormal_endolymph1.07492010
95MP0000955_abnormal_spinal_cord1.06631568
96MP0003011_delayed_dark_adaptation1.06186823
97MP0002168_other_aberrant_phenotype1.04971165
98MP0002152_abnormal_brain_morphology1.04002251
99MP0003879_abnormal_hair_cell1.03760059
100MP0000678_abnormal_parathyroid_gland1.03385446
101MP0010678_abnormal_skin_adnexa1.03168187
102MP0003935_abnormal_craniofacial_develop1.03071766
103MP0010234_abnormal_vibrissa_follicle1.01492975
104MP0003137_abnormal_impulse_conducting1.01130370
105MP0001346_abnormal_lacrimal_gland1.00766305
106MP0003861_abnormal_nervous_system1.00641661
107MP0000383_abnormal_hair_follicle1.00575668
108MP0000026_abnormal_inner_ear0.99630984
109MP0001340_abnormal_eyelid_morphology0.97864465
110MP0001970_abnormal_pain_threshold0.97720245
111MP0005380_embryogenesis_phenotype0.97495796
112MP0001672_abnormal_embryogenesis/_devel0.97495796
113MP0003122_maternal_imprinting0.96331513
114MP0003699_abnormal_female_reproductive0.94940167
115MP0005076_abnormal_cell_differentiation0.94000141
116MP0004858_abnormal_nervous_system0.91873508
117MP0000647_abnormal_sebaceous_gland0.91798800
118MP0001485_abnormal_pinna_reflex0.90976188
119MP0001299_abnormal_eye_distance/0.90743076
120MP0000427_abnormal_hair_cycle0.90737899
121MP0004134_abnormal_chest_morphology0.90693376
122MP0000432_abnormal_head_morphology0.90519837
123MP0000350_abnormal_cell_proliferation0.90513739
124MP0002282_abnormal_trachea_morphology0.90016570
125MP0005391_vision/eye_phenotype0.89783267
126MP0005423_abnormal_somatic_nervous0.89726204
127MP0002882_abnormal_neuron_morphology0.89664204
128MP0002067_abnormal_sensory_capabilities0.88502059
129MP0002932_abnormal_joint_morphology0.87729852
130MP0003634_abnormal_glial_cell0.87470862
131MP0001286_abnormal_eye_development0.86677617
132MP0000762_abnormal_tongue_morphology0.84614889
133MP0002064_seizures0.83720316
134MP0002736_abnormal_nociception_after0.83142684
135MP0003878_abnormal_ear_physiology0.82823404
136MP0005377_hearing/vestibular/ear_phenot0.82823404
137MP0002877_abnormal_melanocyte_morpholog0.82433010
138MP0006072_abnormal_retinal_apoptosis0.82373748
139MP0000579_abnormal_nail_morphology0.82039214
140MP0003252_abnormal_bile_duct0.81446316
141MP0002249_abnormal_larynx_morphology0.81410410
142MP0002089_abnormal_postnatal_growth/wei0.81163835
143MP0002272_abnormal_nervous_system0.80943041
144MP0004197_abnormal_fetal_growth/weight/0.80848513
145MP0002111_abnormal_tail_morphology0.80672640
146MP0005408_hypopigmentation0.79045487
147MP0009745_abnormal_behavioral_response0.78477992
148MP0003942_abnormal_urinary_system0.77841746
149MP0001293_anophthalmia0.77084019
150MP0005386_behavior/neurological_phenoty0.76418002
151MP0004924_abnormal_behavior0.76418002
152MP0009250_abnormal_appendicular_skeleto0.74613258
153MP0003123_paternal_imprinting0.74542262
154MP0002697_abnormal_eye_size0.73988459
155MP0003115_abnormal_respiratory_system0.73959879
156MP0002081_perinatal_lethality0.73373490
157MP0005395_other_phenotype0.72407658
158MP0004381_abnormal_hair_follicle0.71626199
159MP0002066_abnormal_motor_capabilities/c0.71001632
160MP0003283_abnormal_digestive_organ0.70235640
161MP0002909_abnormal_adrenal_gland0.68876066
162MP0002752_abnormal_somatic_nervous0.68341969
163MP0002127_abnormal_cardiovascular_syste0.65513105
164MP0009703_decreased_birth_body0.64452988
165MP0002116_abnormal_craniofacial_bone0.64252995
166MP0009053_abnormal_anal_canal0.62878880
167MP0001324_abnormal_eye_pigmentation0.62771148

Predicted human phenotypes

RankGene SetZ-score
1Facial hemangioma (HP:0000329)6.28373103
2Progressive cerebellar ataxia (HP:0002073)5.61129281
3Hepatoblastoma (HP:0002884)5.17834701
4Abnormality of the labia minora (HP:0012880)5.14714816
5Alacrima (HP:0000522)4.82579476
6Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.22538750
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.20000321
8Polyphagia (HP:0002591)4.17654652
9Dynein arm defect of respiratory motile cilia (HP:0012255)3.99437358
10Absent/shortened dynein arms (HP:0200106)3.99437358
11Abnormal ciliary motility (HP:0012262)3.90326482
12Shallow orbits (HP:0000586)3.88647959
13Decreased lacrimation (HP:0000633)3.86331503
14Ependymoma (HP:0002888)3.81791527
15Increased density of long bones (HP:0006392)3.80419022
16Abnormal respiratory motile cilium physiology (HP:0012261)3.70843391
17Microglossia (HP:0000171)3.68717440
18Chronic hepatic failure (HP:0100626)3.67493769
19Short 4th metacarpal (HP:0010044)3.60968884
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.60968884
21Aplasia/Hypoplasia of the sternum (HP:0006714)3.60908620
22Posterior subcapsular cataract (HP:0007787)3.60548735
23Widely patent fontanelles and sutures (HP:0004492)3.56812259
24Abnormal respiratory motile cilium morphology (HP:0005938)3.54469469
25Abnormal respiratory epithelium morphology (HP:0012253)3.54469469
26Abnormality of the metopic suture (HP:0005556)3.38301797
27Febrile seizures (HP:0002373)3.35920710
28Spinal muscular atrophy (HP:0007269)3.32529820
29Rhinitis (HP:0012384)3.29103381
30Truncal ataxia (HP:0002078)3.28648127
31Hydroureter (HP:0000072)3.25153391
32Postural tremor (HP:0002174)3.25090491
33Hyperglycemia (HP:0003074)3.21276676
34Retinal dysplasia (HP:0007973)3.11057494
35Broad ribs (HP:0000885)3.06687801
36Long clavicles (HP:0000890)3.03315530
37Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.99618909
38Short 1st metacarpal (HP:0010034)2.99618909
39Gaze-evoked nystagmus (HP:0000640)2.92045071
40Abnormality of the astrocytes (HP:0100707)2.89481909
41Astrocytoma (HP:0009592)2.89481909
42Choanal stenosis (HP:0000452)2.88892678
43Abnormal eating behavior (HP:0100738)2.85868438
44Tented upper lip vermilion (HP:0010804)2.84020514
45Meningioma (HP:0002858)2.74273616
46Male infertility (HP:0003251)2.73234247
47Abnormality of the aortic arch (HP:0012303)2.68033009
48Insulin-resistant diabetes mellitus (HP:0000831)2.62289446
49Subcapsular cataract (HP:0000523)2.60878554
50Insidious onset (HP:0003587)2.60377303
51Termporal pattern (HP:0011008)2.60377303
52Chronic bronchitis (HP:0004469)2.58393753
53Abnormality of the 4th metacarpal (HP:0010012)2.57082820
54Poor eye contact (HP:0000817)2.51822567
55Abnormality of the 1st metacarpal (HP:0010009)2.51245848
56Horizontal nystagmus (HP:0000666)2.50037643
57Abnormality of ocular smooth pursuit (HP:0000617)2.46151223
58Wide cranial sutures (HP:0010537)2.45311135
59Germ cell neoplasia (HP:0100728)2.44047292
60Flattened epiphyses (HP:0003071)2.43503729
61Ulnar bowing (HP:0003031)2.43354889
62Hypoplastic nipples (HP:0002557)2.41914237
63Abnormality of the pubic bones (HP:0003172)2.41503895
64Urinary bladder sphincter dysfunction (HP:0002839)2.41030171
65Aplasia/Hypoplasia of the fovea (HP:0008060)2.39710276
66Hypoplasia of the fovea (HP:0007750)2.39710276
67High anterior hairline (HP:0009890)2.38175541
68Oligodactyly (HP:0012165)2.37928642
69Infertility (HP:0000789)2.36524114
70Myokymia (HP:0002411)2.36241953
71Small epiphyses (HP:0010585)2.31433504
72Acute lymphatic leukemia (HP:0006721)2.26483900
73Bicornuate uterus (HP:0000813)2.25799387
74Albinism (HP:0001022)2.24273004
75Abnormal social behavior (HP:0012433)2.23260381
76Impaired social interactions (HP:0000735)2.23260381
77Small hand (HP:0200055)2.22428916
78Urinary urgency (HP:0000012)2.21261560
79Increased nuchal translucency (HP:0010880)2.18559630
80Glioma (HP:0009733)2.18171956
81Myelomeningocele (HP:0002475)2.17407431
82Renovascular hypertension (HP:0100817)2.16021245
83Papillary thyroid carcinoma (HP:0002895)2.14668508
84Adrenal hypoplasia (HP:0000835)2.14353227
85Hypoplastic labia majora (HP:0000059)2.14300646
86Abnormality of the intervertebral disk (HP:0005108)2.11969688
87Benign neoplasm of the central nervous system (HP:0100835)2.11438366
88Intellectual disability, moderate (HP:0002342)2.10463129
89Dysmetric saccades (HP:0000641)2.09588217
90Abnormal lung lobation (HP:0002101)2.07952603
91Aplasia/Hypoplasia of the nipples (HP:0006709)2.07928993
92Fibular hypoplasia (HP:0003038)2.06854646
93Open mouth (HP:0000194)2.06052423
94Tubulointerstitial nephritis (HP:0001970)2.05787145
95Short chin (HP:0000331)2.05236894
96Hypsarrhythmia (HP:0002521)2.03621861
97Labial hypoplasia (HP:0000066)2.01837980
98Ureteral stenosis (HP:0000071)2.01446099
99Neoplasm of the peripheral nervous system (HP:0100007)2.00782989
100Oligodactyly (hands) (HP:0001180)2.00624792
101EEG with generalized epileptiform discharges (HP:0011198)1.99665397
102Natal tooth (HP:0000695)1.99298979
103Protruding tongue (HP:0010808)1.98655762
104Cutaneous finger syndactyly (HP:0010554)1.98332749
105Morphological abnormality of the middle ear (HP:0008609)1.98326446
106Abnormality of the phalanges of the hallux (HP:0010057)1.98221451
107Bifid scrotum (HP:0000048)1.98204443
108Cutis marmorata (HP:0000965)1.96136345
109Capillary hemangiomas (HP:0005306)1.93737406
110Bell-shaped thorax (HP:0001591)1.93332618
111Cone-rod dystrophy (HP:0000548)1.93330581
112Heterotopia (HP:0002282)1.93265092
113Epileptiform EEG discharges (HP:0011182)1.91254976
114Limb ataxia (HP:0002070)1.90849954
115Abnormality of the corticospinal tract (HP:0002492)1.90430215
116Volvulus (HP:0002580)1.89055346
117Abnormality of the diencephalon (HP:0010662)1.88660714
118Abnormality of the labia majora (HP:0012881)1.88624394
119Glossoptosis (HP:0000162)1.88577581
120Abnormality of the antihelix (HP:0009738)1.88086944
121Sleep apnea (HP:0010535)1.86733913
122Action tremor (HP:0002345)1.86278003
123Fair hair (HP:0002286)1.86144805
124Ureteral obstruction (HP:0006000)1.85436069
125Neonatal short-limb short stature (HP:0008921)1.85361000
126Short phalanx of the thumb (HP:0009660)1.85298049
127Advanced eruption of teeth (HP:0006288)1.84498803
128Nephronophthisis (HP:0000090)1.82820340
129Tibial bowing (HP:0002982)1.82713385
130Facial cleft (HP:0002006)1.82501080
131Proximal amyotrophy (HP:0007126)1.81830069
132Abnormality of the fovea (HP:0000493)1.81525109
133Broad hallux (HP:0010055)1.81436065
134Abnormality of the lower motor neuron (HP:0002366)1.81268068
135Blue irides (HP:0000635)1.81259370
136Apathy (HP:0000741)1.79571548
137Thyroid carcinoma (HP:0002890)1.78503722
138Sclerocornea (HP:0000647)1.78167676
139Rib fusion (HP:0000902)1.78153186
140Atresia of the external auditory canal (HP:0000413)1.78005300
141Optic nerve hypoplasia (HP:0000609)1.77376745
142Overriding aorta (HP:0002623)1.74817282
143Truncal obesity (HP:0001956)1.74409645
144Bony spicule pigmentary retinopathy (HP:0007737)1.74121975
145Cutaneous syndactyly (HP:0012725)1.73506412
146Abnormality of the ischium (HP:0003174)1.67490927
147Hypoplastic pelvis (HP:0008839)1.64927354
148True hermaphroditism (HP:0010459)1.64655337
149Aplasia/Hypoplasia of the tongue (HP:0010295)1.63540741
15011 pairs of ribs (HP:0000878)1.63040307
151Chromosomal breakage induced by crosslinking agents (HP:0003221)1.62900245
152Occipital encephalocele (HP:0002085)1.61690428
153Bronchiectasis (HP:0002110)1.61600704
154Short nail (HP:0001799)1.60931370
155Selective tooth agenesis (HP:0001592)1.60862256
156Nasal polyposis (HP:0100582)1.58595052
157Ankle contracture (HP:0006466)1.57847104
158Diminished motivation (HP:0000745)1.57835059
159Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.57304047
160Hypoplastic ischia (HP:0003175)1.55249997
161Bifid tongue (HP:0010297)1.54504361
162Drooling (HP:0002307)1.54197272
163Absent frontal sinuses (HP:0002688)1.53514342
164Midline defect of the nose (HP:0004122)1.53029260
165Bronchomalacia (HP:0002780)1.52645447
166Omphalocele (HP:0001539)1.48747949
167Severe visual impairment (HP:0001141)1.48285082
168Type II lissencephaly (HP:0007260)1.46884793
169Preaxial hand polydactyly (HP:0001177)1.46511539
170Hypospadias (HP:0000047)1.46408420
171Radioulnar synostosis (HP:0002974)1.45262481
172Supernumerary spleens (HP:0009799)1.44101354
173Deviation of the thumb (HP:0009603)1.43893387
174Medulloblastoma (HP:0002885)1.43573245
175Abnormality of the renal medulla (HP:0100957)1.42077116
176Missing ribs (HP:0000921)1.39928221
177Aplasia/Hypoplasia of the earlobes (HP:0009906)1.39903122
178Proximal placement of thumb (HP:0009623)1.39350689
179Urethral obstruction (HP:0000796)1.38392754
180Synophrys (HP:0000664)1.38325879

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PAK64.71066855
2MARK14.19658418
3EPHA43.68181199
4MAP3K43.65510290
5MAPK153.17033792
6CDC73.02167893
7VRK12.93652451
8TTK2.75108049
9NEK12.69742645
10STK38L2.43948360
11MAP2K72.35783429
12DYRK22.34930648
13STK242.24613102
14MET2.24050892
15YES12.23300589
16NTRK22.16297563
17EIF2AK32.15120254
18NEK22.12599296
19SIK32.08342477
20MAP3K62.07357700
21CDK122.03191403
22SIK21.98475460
23MAP3K101.84660088
24LMTK21.82100601
25SGK21.80649315
26MKNK21.80296333
27PLK41.79068965
28WEE11.78877991
29MAP3K121.76085429
30SRPK11.73189643
31FGFR21.72384525
32SGK2231.70226139
33SGK4941.70226139
34UHMK11.67710129
35BUB11.64865171
36MAPK131.58188722
37ZAK1.54319816
38PRKD31.52915409
39CAMK1D1.48031029
40MAP2K41.45939260
41PLK11.45240140
42PHKG11.44731162
43PHKG21.44731162
44MAP3K91.43476959
45MKNK11.40064036
46EPHA21.38363869
47MINK11.36285788
48LIMK11.36113765
49SGK31.34367857
50MST1R1.32837185
51PLK21.31254207
52EEF2K1.29605655
53PAK21.29595979
54AURKA1.28889359
55NTRK31.27299502
56PBK1.26071959
57TYRO31.24802930
58PRKCH1.23008712
59TSSK61.21512696
60EPHB21.18374594
61FRK1.16370368
62CHEK21.14807164
63HIPK21.14133898
64BCR1.14034855
65PLK31.13819330
66SIK11.07884351
67GRK51.07543983
68BRSK21.06859032
69INSRR1.01698155
70CDK71.01234517
71TNIK0.96753907
72STK30.96683147
73AURKB0.92852326
74BRSK10.92803391
75CAMK1G0.91867471
76NEK60.91415415
77CASK0.91216039
78MTOR0.90533825
79PRPF4B0.89587903
80PNCK0.89371095
81TAOK30.88605509
82ACVR1B0.87966320
83ADRBK20.81298104
84DYRK1B0.79995168
85STK380.78671153
86PTK20.77827514
87CDK50.77777877
88DYRK1A0.75663377
89MELK0.75496201
90PDGFRA0.73665795
91PRKCG0.73560522
92NTRK10.72189541
93CDK90.71346707
94CDK10.69749474
95DAPK20.69367283
96ATR0.68847406
97BRD40.68726234
98ATM0.68615745
99RPS6KB10.68358444
100TRIB30.67980984
101ROCK10.66879640
102LATS20.66046425
103FGFR40.64649663
104BRAF0.63508720
105CDK30.62230273
106STK110.61614757
107PRKCE0.61512869
108KSR10.61120496
109ICK0.60481819
110CDK20.60092762
111DDR20.59818239
112LATS10.59808143
113PRKD20.59557699
114IRAK20.59257804
115MAPK80.58684687
116RET0.53098143
117PINK10.52871458
118TGFBR10.52230470
119KSR20.52024626
120MAPK100.51979782
121CSNK1E0.49610676
122SGK10.49525627
123CSNK1G10.48683068
124CSNK1G20.48513551
125ADRBK10.48342757
126PASK0.47556907
127PKN10.46422627
128CSNK1G30.45730669
129MAP3K80.45647982
130ROCK20.45007722
131CSNK1A1L0.43936637
132TRIM280.43354037
133SMG10.42452158
134CAMK2G0.42121343
135PAK40.42017359
136RPS6KA20.41813810
137ALK0.41090560
138NUAK10.40204102
139AKT20.40079431
140PAK30.39701261
141CSNK1D0.39063416
142PRKCI0.37677000
143TESK10.37380332
144CAMK40.37248909
145DYRK30.37173898
146CDK11A0.36803913
147PRKACG0.36547159
148CAMK2B0.36526503
149CDK150.36249648
150ABL20.35850675
151CDK180.35701994
152CDK80.35592784
153FGFR30.34399699
154WNK10.34348199
155MAPK90.31931386
156CHEK10.31440862
157PRKACA0.30652321
158ERBB30.29796528
159PRKACB0.29311300
160CAMK2A0.29289192
161GSK3B0.29251664
162GSK3A0.28729601
163RPS6KA30.28032757

Predicted pathways (KEGG)

RankGene SetZ-score
1Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010404.98120892
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.44892522
3Cell cycle_Homo sapiens_hsa041103.13021460
4Taste transduction_Homo sapiens_hsa047422.95041376
5Nicotine addiction_Homo sapiens_hsa050332.43076137
6DNA replication_Homo sapiens_hsa030302.42116178
7Axon guidance_Homo sapiens_hsa043602.41349644
8Mismatch repair_Homo sapiens_hsa034302.31390705
9Fatty acid metabolism_Homo sapiens_hsa012122.31372142
10Serotonergic synapse_Homo sapiens_hsa047262.15827413
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13447167
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.12464174
13Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.06514560
14Glutamatergic synapse_Homo sapiens_hsa047241.93037982
15RNA transport_Homo sapiens_hsa030131.86867335
16Non-homologous end-joining_Homo sapiens_hsa034501.83635560
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.79788798
18GABAergic synapse_Homo sapiens_hsa047271.77837180
19Morphine addiction_Homo sapiens_hsa050321.75464768
20Base excision repair_Homo sapiens_hsa034101.74683584
21Basal cell carcinoma_Homo sapiens_hsa052171.73229160
22Circadian entrainment_Homo sapiens_hsa047131.72647160
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.72117049
24Dopaminergic synapse_Homo sapiens_hsa047281.71851968
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71648825
26Basal transcription factors_Homo sapiens_hsa030221.60507871
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.55704724
28mRNA surveillance pathway_Homo sapiens_hsa030151.54652554
29Olfactory transduction_Homo sapiens_hsa047401.51367022
30MicroRNAs in cancer_Homo sapiens_hsa052061.49685725
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48424266
32Fatty acid degradation_Homo sapiens_hsa000711.45405220
33Viral myocarditis_Homo sapiens_hsa054161.45018588
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.44960101
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.44112417
36Nucleotide excision repair_Homo sapiens_hsa034201.41368863
37ErbB signaling pathway_Homo sapiens_hsa040121.40332696
38PPAR signaling pathway_Homo sapiens_hsa033201.37347696
39p53 signaling pathway_Homo sapiens_hsa041151.37101446
40Dorso-ventral axis formation_Homo sapiens_hsa043201.36187015
41Homologous recombination_Homo sapiens_hsa034401.36129813
42Hedgehog signaling pathway_Homo sapiens_hsa043401.29924281
43Cholinergic synapse_Homo sapiens_hsa047251.29413622
44Synaptic vesicle cycle_Homo sapiens_hsa047211.23741447
45Fanconi anemia pathway_Homo sapiens_hsa034601.21661637
46Notch signaling pathway_Homo sapiens_hsa043301.15950613
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.14335208
48cAMP signaling pathway_Homo sapiens_hsa040241.13565078
49Fatty acid biosynthesis_Homo sapiens_hsa000611.10605420
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.10273295
51Wnt signaling pathway_Homo sapiens_hsa043101.09714370
52TGF-beta signaling pathway_Homo sapiens_hsa043501.06509531
53Insulin secretion_Homo sapiens_hsa049111.04911820
54Dilated cardiomyopathy_Homo sapiens_hsa054141.03556208
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01737986
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01240397
57Amphetamine addiction_Homo sapiens_hsa050310.99518152
58Hippo signaling pathway_Homo sapiens_hsa043900.97199860
59Prostate cancer_Homo sapiens_hsa052150.96808338
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.96350687
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95416540
62Estrogen signaling pathway_Homo sapiens_hsa049150.95016057
63Insulin signaling pathway_Homo sapiens_hsa049100.94781145
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.92872198
65* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91814861
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91027725
67Colorectal cancer_Homo sapiens_hsa052100.89857718
68Renal cell carcinoma_Homo sapiens_hsa052110.89638161
69GnRH signaling pathway_Homo sapiens_hsa049120.88990741
70Type II diabetes mellitus_Homo sapiens_hsa049300.88194370
71Ether lipid metabolism_Homo sapiens_hsa005650.87172072
72Lysine degradation_Homo sapiens_hsa003100.86873122
73Cocaine addiction_Homo sapiens_hsa050300.86533864
74Small cell lung cancer_Homo sapiens_hsa052220.84150040
75Bladder cancer_Homo sapiens_hsa052190.83999920
76Prion diseases_Homo sapiens_hsa050200.83562268
77Calcium signaling pathway_Homo sapiens_hsa040200.83340903
78Endometrial cancer_Homo sapiens_hsa052130.83052834
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81788881
80Long-term potentiation_Homo sapiens_hsa047200.80758976
81Inositol phosphate metabolism_Homo sapiens_hsa005620.80135852
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78906407
83Salivary secretion_Homo sapiens_hsa049700.78745424
84Proteoglycans in cancer_Homo sapiens_hsa052050.76804642
85Circadian rhythm_Homo sapiens_hsa047100.74942843
86Spliceosome_Homo sapiens_hsa030400.74349188
87Linoleic acid metabolism_Homo sapiens_hsa005910.74148893
88RNA polymerase_Homo sapiens_hsa030200.72831129
89Ras signaling pathway_Homo sapiens_hsa040140.72784057
90Thyroid cancer_Homo sapiens_hsa052160.72459807
91Purine metabolism_Homo sapiens_hsa002300.71482698
92Chronic myeloid leukemia_Homo sapiens_hsa052200.71280172
93MAPK signaling pathway_Homo sapiens_hsa040100.71111442
94mTOR signaling pathway_Homo sapiens_hsa041500.70938496
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70544200
96Renin secretion_Homo sapiens_hsa049240.69994833
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69898380
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69824810
99Insulin resistance_Homo sapiens_hsa049310.69637150
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67914479
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67518036
102Alcoholism_Homo sapiens_hsa050340.67487583
103ECM-receptor interaction_Homo sapiens_hsa045120.66273345
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64442178
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64296191
106Butanoate metabolism_Homo sapiens_hsa006500.63692393
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63525638
108Melanogenesis_Homo sapiens_hsa049160.63302714
109Melanoma_Homo sapiens_hsa052180.62476785
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60741551
111Ovarian steroidogenesis_Homo sapiens_hsa049130.60628279
112Selenocompound metabolism_Homo sapiens_hsa004500.59923032
113Non-small cell lung cancer_Homo sapiens_hsa052230.59599332
114Gap junction_Homo sapiens_hsa045400.59454181
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59412539
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58411549
117Oocyte meiosis_Homo sapiens_hsa041140.57877043
118Tight junction_Homo sapiens_hsa045300.56541433
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54984331
120Gastric acid secretion_Homo sapiens_hsa049710.54123039
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.52722926
122Viral carcinogenesis_Homo sapiens_hsa052030.52482601
123N-Glycan biosynthesis_Homo sapiens_hsa005100.52001540
124Pyrimidine metabolism_Homo sapiens_hsa002400.51746370
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.51697691
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.51468862
127FoxO signaling pathway_Homo sapiens_hsa040680.51063438
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50133145
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49822781
130Phototransduction_Homo sapiens_hsa047440.49676423
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49459731
132Pathways in cancer_Homo sapiens_hsa052000.47763521
133Long-term depression_Homo sapiens_hsa047300.45299794
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43722963
135Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43216127
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42722912
137Choline metabolism in cancer_Homo sapiens_hsa052310.39073098
138Rap1 signaling pathway_Homo sapiens_hsa040150.38866493
139AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38721294
140Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38592668
141Focal adhesion_Homo sapiens_hsa045100.38584021
142Adherens junction_Homo sapiens_hsa045200.35375031
143Sphingolipid metabolism_Homo sapiens_hsa006000.34995670
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.34127989
145AMPK signaling pathway_Homo sapiens_hsa041520.33098425
146Oxytocin signaling pathway_Homo sapiens_hsa049210.31580586
147Glioma_Homo sapiens_hsa052140.31390374
148Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30457076
149Steroid biosynthesis_Homo sapiens_hsa001000.30447041

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