GPR157

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.54980688
2kynurenine metabolic process (GO:0070189)5.42669025
3regulation of skeletal muscle contraction (GO:0014819)5.27964851
4sarcomere organization (GO:0045214)5.14210270
5myofibril assembly (GO:0030239)5.07657826
6opioid receptor signaling pathway (GO:0038003)5.04813863
7indole-containing compound catabolic process (GO:0042436)4.93759534
8indolalkylamine catabolic process (GO:0046218)4.93759534
9tryptophan catabolic process (GO:0006569)4.93759534
10regulation of relaxation of muscle (GO:1901077)4.70695125
11indolalkylamine metabolic process (GO:0006586)4.67860704
12regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.63891723
13muscle filament sliding (GO:0030049)4.59827859
14actin-myosin filament sliding (GO:0033275)4.59827859
15cardiac myofibril assembly (GO:0055003)4.57678794
16response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.39808146
17sarcoplasmic reticulum calcium ion transport (GO:0070296)4.30778753
18regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.27191937
19positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.25609169
20tryptophan metabolic process (GO:0006568)4.15110122
21actin-mediated cell contraction (GO:0070252)4.02314401
22regulation of sarcomere organization (GO:0060297)3.97707537
23heart process (GO:0003015)3.95730224
24heart contraction (GO:0060047)3.95730224
25skeletal muscle contraction (GO:0003009)3.92552688
26regulation of cell communication by electrical coupling (GO:0010649)3.82685104
27regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.79641237
28daunorubicin metabolic process (GO:0044597)3.75268555
29polyketide metabolic process (GO:0030638)3.75268555
30doxorubicin metabolic process (GO:0044598)3.75268555
31primary amino compound metabolic process (GO:1901160)3.71740844
32cellular response to ATP (GO:0071318)3.70712598
33regulation of actin filament-based movement (GO:1903115)3.68793884
34bundle of His cell to Purkinje myocyte communication (GO:0086069)3.68432415
35cardiac muscle hypertrophy (GO:0003300)3.64790313
36cardiac muscle contraction (GO:0060048)3.63948988
37indole-containing compound metabolic process (GO:0042430)3.63468402
38superoxide anion generation (GO:0042554)3.62346776
39striated muscle contraction (GO:0006941)3.61340863
40serotonin metabolic process (GO:0042428)3.49688561
41adult heart development (GO:0007512)3.47893563
42response to pheromone (GO:0019236)3.47556626
43striated muscle hypertrophy (GO:0014897)3.45119302
44skeletal muscle adaptation (GO:0043501)3.40742083
45positive regulation by symbiont of host defense response (GO:0052509)3.40431868
46modulation by symbiont of host defense response (GO:0052031)3.40431868
47modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.40431868
48modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.40431868
49positive regulation by organism of defense response of other organism involved in symbiotic interact3.40431868
50modulation by symbiont of host immune response (GO:0052553)3.40431868
51regulation of striated muscle contraction (GO:0006942)3.39158423
52cellular ketone body metabolic process (GO:0046950)3.36489304
53muscle hypertrophy (GO:0014896)3.35257990
54amine catabolic process (GO:0009310)3.32394535
55cellular biogenic amine catabolic process (GO:0042402)3.32394535
56G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.29468998
57cellular response to zinc ion (GO:0071294)3.28714216
58detection of light stimulus involved in sensory perception (GO:0050962)3.27318645
59detection of light stimulus involved in visual perception (GO:0050908)3.27318645
60cardiac muscle tissue morphogenesis (GO:0055008)3.26801671
61actomyosin structure organization (GO:0031032)3.26148324
62synaptic transmission, cholinergic (GO:0007271)3.24098483
63positive regulation of antigen processing and presentation (GO:0002579)3.23660596
64mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.21977029
65mitochondrial respiratory chain complex I assembly (GO:0032981)3.21977029
66NADH dehydrogenase complex assembly (GO:0010257)3.21977029
67ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.21778119
68gamma-aminobutyric acid transport (GO:0015812)3.20402802
69striated muscle atrophy (GO:0014891)3.20326964
70water-soluble vitamin biosynthetic process (GO:0042364)3.20059352
71muscle atrophy (GO:0014889)3.19983398
72positive regulation of fatty acid oxidation (GO:0046321)3.19113540
73platelet dense granule organization (GO:0060155)3.17706379
74otic vesicle formation (GO:0030916)3.16801145
75fucose catabolic process (GO:0019317)3.15945650
76L-fucose metabolic process (GO:0042354)3.15945650
77L-fucose catabolic process (GO:0042355)3.15945650
78ventricular cardiac muscle cell action potential (GO:0086005)3.15406075
79ketone body metabolic process (GO:1902224)3.12844884
80kidney morphogenesis (GO:0060993)3.09429448
81regulation of activation of Janus kinase activity (GO:0010533)3.08745535
82pyrimidine ribonucleoside catabolic process (GO:0046133)3.07544486
83negative regulation of cytosolic calcium ion concentration (GO:0051481)3.04778702
84negative regulation of cardiac muscle hypertrophy (GO:0010614)3.03470084
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.02033251
86hindbrain development (GO:0030902)3.01123163
87protein complex biogenesis (GO:0070271)3.00586104
88microglial cell activation (GO:0001774)3.00113169
89regulation of dendritic cell antigen processing and presentation (GO:0002604)2.99962689
90negative regulation of muscle hypertrophy (GO:0014741)2.98951042
91negative regulation of nitric-oxide synthase activity (GO:0051001)2.98386851
92regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.97512450
93regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.96193154
94response to muscle activity (GO:0014850)2.96182883
95cardiac muscle cell development (GO:0055013)2.95316532
96response to host immune response (GO:0052572)2.94470653
97response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.94470653
98regulation of membrane repolarization (GO:0060306)2.92558558
99negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.91299961
100detection of calcium ion (GO:0005513)2.90904764
101cornea development in camera-type eye (GO:0061303)2.90697414
102neuronal action potential (GO:0019228)2.90267627
103regulation of cardiac muscle contraction (GO:0055117)2.90159087
104detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.89857666
105cardiac cell development (GO:0055006)2.89125680
106cardiac chamber formation (GO:0003207)2.89048107
107muscle tissue morphogenesis (GO:0060415)2.87588024
108response to inactivity (GO:0014854)2.87512163
109positive regulation of fatty acid transport (GO:2000193)2.86921610
110positive regulation of cellular amide metabolic process (GO:0034250)2.85814999
111aromatic amino acid family catabolic process (GO:0009074)2.84902926
112actin filament-based movement (GO:0030048)2.83680444
113striated muscle adaptation (GO:0014888)2.81701655
114benzene-containing compound metabolic process (GO:0042537)2.80956179
115regulation of antigen processing and presentation (GO:0002577)2.79410090
116positive regulation of heart rate (GO:0010460)2.78477294
117cytidine metabolic process (GO:0046087)2.78110115
118cytidine catabolic process (GO:0006216)2.78110115
119cytidine deamination (GO:0009972)2.78110115
120negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.78048942
121dendritic cell chemotaxis (GO:0002407)2.76147322
122spinal cord motor neuron differentiation (GO:0021522)2.76000768
123somite development (GO:0061053)2.75208152
124epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.75138077
125NAD biosynthetic process (GO:0009435)2.74698347
126mitochondrial respiratory chain complex assembly (GO:0033108)2.74500135
127membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.74486287
128purinergic nucleotide receptor signaling pathway (GO:0035590)2.74411074
129energy homeostasis (GO:0097009)2.73984279
130regulation of sequestering of triglyceride (GO:0010889)2.73768767
131positive regulation of defense response to virus by host (GO:0002230)2.73020132
132desmosome organization (GO:0002934)2.72105903
133negative regulation of potassium ion transmembrane transport (GO:1901380)2.71693810
134cardiac muscle cell action potential (GO:0086001)2.69680990
135peristalsis (GO:0030432)2.69625608
136muscle adaptation (GO:0043500)2.67895473
137response to peptidoglycan (GO:0032494)2.67798913
138cardiac muscle hypertrophy in response to stress (GO:0014898)2.67417658
139muscle hypertrophy in response to stress (GO:0003299)2.67417658
140cardiac muscle adaptation (GO:0014887)2.67417658
141dendritic cell migration (GO:0036336)2.67249416
142cardiac ventricle formation (GO:0003211)2.65919845
143phosphatidylinositol acyl-chain remodeling (GO:0036149)2.65282057
144aromatic amino acid family metabolic process (GO:0009072)2.64447773
145adrenergic receptor signaling pathway (GO:0071875)2.63497574
146protein localization to microtubule cytoskeleton (GO:0072698)2.62447370
147positive regulation of action potential (GO:0045760)2.61821841
148adenosine metabolic process (GO:0046085)2.61708375
149respiratory chain complex IV assembly (GO:0008535)2.60164808
150cAMP catabolic process (GO:0006198)2.59764116
151relaxation of cardiac muscle (GO:0055119)2.59522704
152negative regulation of cAMP-mediated signaling (GO:0043951)2.58549792
153positive regulation of heat generation (GO:0031652)2.58472108
154negative regulation of systemic arterial blood pressure (GO:0003085)2.57905862
155cardiac conduction (GO:0061337)2.56461264
156positive regulation of vascular permeability (GO:0043117)2.56311196
157mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.55153221
158behavioral response to ethanol (GO:0048149)2.52464941
159regulation of triglyceride biosynthetic process (GO:0010866)2.52054611
160positive regulation of fatty acid beta-oxidation (GO:0032000)2.51692322
161protein localization to cytoskeleton (GO:0044380)2.51556299
162sulfation (GO:0051923)2.49361690
163nephron epithelium morphogenesis (GO:0072088)2.48155190
164nephron tubule morphogenesis (GO:0072078)2.48155190
165neural tube formation (GO:0001841)2.48125831
166negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.47885804
167negative regulation of reactive oxygen species metabolic process (GO:2000378)2.47218240
168regulation of mesenchymal cell apoptotic process (GO:2001053)2.46030692
169regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.45663825
170reflex (GO:0060004)2.45576339
171regulation of action potential (GO:0098900)2.45232247
172regulation of memory T cell differentiation (GO:0043380)2.44713702
173transepithelial transport (GO:0070633)2.43659724
174regulation of glucokinase activity (GO:0033131)2.42541107
175regulation of hexokinase activity (GO:1903299)2.42541107
176neurotransmitter metabolic process (GO:0042133)2.39930230
177positive regulation of triglyceride biosynthetic process (GO:0010867)2.39289011
178positive regulation of T-helper 1 type immune response (GO:0002827)2.39172706
1793-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.37876533
180purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.37876533
181auditory receptor cell stereocilium organization (GO:0060088)2.36561518
182dopamine transport (GO:0015872)2.35950668
183neurotransmitter catabolic process (GO:0042135)2.35679234
184piRNA metabolic process (GO:0034587)2.34716442
185molting cycle (GO:0042303)2.33930491
186hair cycle (GO:0042633)2.33930491
187embryonic epithelial tube formation (GO:0001838)2.33700140
188regulation of hippo signaling (GO:0035330)2.33624164
189inner ear receptor stereocilium organization (GO:0060122)2.31942844
190protein localization to microtubule (GO:0035372)2.31372734
191negative regulation of telomere maintenance (GO:0032205)2.30031489

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.22196857
2ZNF274_21170338_ChIP-Seq_K562_Hela3.48360163
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.13761329
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.11996163
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.03162341
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.97357403
7GBX2_23144817_ChIP-Seq_PC3_Human2.53805527
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.36894419
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.36733963
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.33300774
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27014693
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.25447528
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.10227377
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.10176960
15SUZ12_27294783_Chip-Seq_NPCs_Mouse2.06763300
16PCGF2_27294783_Chip-Seq_NPCs_Mouse2.00361775
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.99767904
18SMAD_19615063_ChIP-ChIP_OVARY_Human1.97488367
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.95719053
20FUS_26573619_Chip-Seq_HEK293_Human1.93828511
21NFE2_27457419_Chip-Seq_LIVER_Mouse1.90710145
22EZH2_22144423_ChIP-Seq_EOC_Human1.89237536
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.85559951
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84146972
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82159744
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78858019
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78845851
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.76796593
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76032905
30EZH2_27294783_Chip-Seq_NPCs_Mouse1.73716495
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.73637797
32EWS_26573619_Chip-Seq_HEK293_Human1.64195615
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.63746228
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61171443
35STAT3_18555785_Chip-Seq_ESCs_Mouse1.60993497
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.59426177
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58640229
38E2F1_18555785_Chip-Seq_ESCs_Mouse1.58157653
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.56978039
40BCAT_22108803_ChIP-Seq_LS180_Human1.55653172
41NR3C1_21868756_ChIP-Seq_MCF10A_Human1.54058193
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.53503423
43VDR_22108803_ChIP-Seq_LS180_Human1.52427142
44SUZ12_18555785_Chip-Seq_ESCs_Mouse1.51974610
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50816937
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.50582298
47AR_25329375_ChIP-Seq_VCAP_Human1.49891847
48EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.49033299
49SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45713273
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.45178187
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.45178187
52P53_22387025_ChIP-Seq_ESCs_Mouse1.44117286
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.43390629
54NMYC_18555785_Chip-Seq_ESCs_Mouse1.43301203
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41005381
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40701802
57EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.38574917
58SOX2_19829295_ChIP-Seq_ESCs_Human1.38038054
59NANOG_19829295_ChIP-Seq_ESCs_Human1.38038054
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37936669
61CBP_20019798_ChIP-Seq_JUKART_Human1.37936669
62ZFX_18555785_Chip-Seq_ESCs_Mouse1.37280006
63P300_19829295_ChIP-Seq_ESCs_Human1.36296712
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.34755405
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34039821
66SOX2_18555785_Chip-Seq_ESCs_Mouse1.33640752
67RUNX1_27457419_Chip-Seq_LIVER_Mouse1.32583062
68PU1_27457419_Chip-Seq_LIVER_Mouse1.32437847
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30610795
70* STAT3_23295773_ChIP-Seq_U87_Human1.30201570
71OCT4_18555785_Chip-Seq_ESCs_Mouse1.30095308
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29440572
73IGF1R_20145208_ChIP-Seq_DFB_Human1.29121485
74P300_18555785_Chip-Seq_ESCs_Mouse1.28906423
75PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27855751
76TP53_22573176_ChIP-Seq_HFKS_Human1.24946772
77RNF2_27304074_Chip-Seq_NSC_Mouse1.24801398
78VDR_24787735_ChIP-Seq_THP-1_Human1.24224774
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24052739
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.23462715
81STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23451064
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.23027484
83CMYC_18555785_Chip-Seq_ESCs_Mouse1.22463048
84TCF4_23295773_ChIP-Seq_U87_Human1.21847484
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.21094544
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.20862555
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.20779449
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20566295
89* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20377636
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.20352312
91SMAD4_21799915_ChIP-Seq_A2780_Human1.18888925
92* TBX20_22080862_ChIP-Seq_HEART_Mouse1.18753199
93* TBX20_22328084_ChIP-Seq_HEART_Mouse1.18753199
94EZH2_27304074_Chip-Seq_ESCs_Mouse1.17863983
95SALL1_21062744_ChIP-ChIP_HESCs_Human1.17532236
96SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.17045123
97CDX2_22108803_ChIP-Seq_LS180_Human1.16845647
98AR_20517297_ChIP-Seq_VCAP_Human1.16156672
99GATA3_21878914_ChIP-Seq_MCF-7_Human1.16108664
100KLF4_18555785_Chip-Seq_ESCs_Mouse1.15843515
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14978041
102ESRRB_18555785_Chip-Seq_ESCs_Mouse1.14704463
103* RUNX_20019798_ChIP-Seq_JUKART_Human1.14244308
104OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14139946
105THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13996992
106SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13744225
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.13573643
108HOXB7_26014856_ChIP-Seq_BT474_Human1.13233985
109SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13080179
110RUNX2_22187159_ChIP-Seq_PCA_Human1.12691510
111ER_23166858_ChIP-Seq_MCF-7_Human1.12689727
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12323278
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11966805
114AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11594952
115KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10281491
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09068750
117CTCF_18555785_Chip-Seq_ESCs_Mouse1.08842284
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08594411
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08567424
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08567424
121TAF15_26573619_Chip-Seq_HEK293_Human1.07965420
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07449631
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.06783314
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05938554
125TCF4_22108803_ChIP-Seq_LS180_Human1.05634981
126TP53_18474530_ChIP-ChIP_U2OS_Human1.04923171
127FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04798307
128AHR_22903824_ChIP-Seq_MCF-7_Human1.04539164
129PIAS1_25552417_ChIP-Seq_VCAP_Human1.04165491
130SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03945488
131TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02916447
132EED_16625203_ChIP-ChIP_MESCs_Mouse1.02622408
133SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02541267
134NCOR_22424771_ChIP-Seq_293T_Human1.02242992
135ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02176239
136TAL1_26923725_Chip-Seq_HPCs_Mouse1.02156577
137JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02118459
138SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01388328
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01345696
140EZH2_27294783_Chip-Seq_ESCs_Mouse1.01013005
141FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00104639
142SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99934323
143SCL_19346495_ChIP-Seq_HPC-7_Human0.99877426
144DROSHA_22980978_ChIP-Seq_HELA_Human0.99463912
145RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99255908
146AR_21572438_ChIP-Seq_LNCaP_Human0.99086772
147SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98440191
148LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98205688
149* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.97977627
150PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97718581
151REST_21632747_ChIP-Seq_MESCs_Mouse0.97539593
152PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95417495
153TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95347800
154OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94774363
155JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94308752
156TP63_19390658_ChIP-ChIP_HaCaT_Human0.93732314

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.99698216
2MP0002837_dystrophic_cardiac_calcinosis4.91929446
3MP0000751_myopathy3.73941931
4MP0004215_abnormal_myocardial_fiber3.59334386
5MP0003195_calcinosis3.59326938
6MP0000749_muscle_degeneration3.51754546
7MP0004084_abnormal_cardiac_muscle3.38192038
8MP0004036_abnormal_muscle_relaxation2.83382973
9MP0003011_delayed_dark_adaptation2.82176303
10MP0004510_myositis2.80574437
11MP0003828_pulmonary_edema2.47819826
12MP0005670_abnormal_white_adipose2.47297917
13MP0000566_synostosis2.44597361
14MP0005330_cardiomyopathy2.42760443
15MP0002972_abnormal_cardiac_muscle2.41192603
16MP0001835_abnormal_antigen_presentation2.25147799
17MP0004885_abnormal_endolymph2.21654236
18MP0003137_abnormal_impulse_conducting2.21339807
19MP0008875_abnormal_xenobiotic_pharmacok2.14562138
20MP0005620_abnormal_muscle_contractility2.13373696
21MP0002106_abnormal_muscle_physiology2.06053990
22MP0000569_abnormal_digit_pigmentation2.05257791
23MP0000383_abnormal_hair_follicle2.03951252
24MP0005551_abnormal_eye_electrophysiolog2.03043834
25MP0000750_abnormal_muscle_regeneration2.02197218
26MP0002277_abnormal_respiratory_mucosa2.02122461
27MP0004484_altered_response_of1.94491692
28MP0002148_abnormal_hypersensitivity_rea1.93998076
29MP0002102_abnormal_ear_morphology1.93509670
30MP0004043_abnormal_pH_regulation1.90695695
31MP0004087_abnormal_muscle_fiber1.83432772
32MP0008775_abnormal_heart_ventricle1.80907163
33MP0004145_abnormal_muscle_electrophysio1.74841557
34MP0008872_abnormal_physiological_respon1.74516400
35MP0000427_abnormal_hair_cycle1.73543128
36MP0001485_abnormal_pinna_reflex1.73185343
37MP0001544_abnormal_cardiovascular_syste1.71721011
38MP0005385_cardiovascular_system_phenoty1.71721011
39MP0002938_white_spotting1.71694743
40MP0001986_abnormal_taste_sensitivity1.70756902
41MP0004142_abnormal_muscle_tone1.68745409
42MP0005369_muscle_phenotype1.66759118
43MP0001188_hyperpigmentation1.64698098
44MP0001501_abnormal_sleep_pattern1.58462719
45MP0001968_abnormal_touch/_nociception1.57800679
46MP0002736_abnormal_nociception_after1.57558902
47MP0004130_abnormal_muscle_cell1.55277271
48MP0005387_immune_system_phenotype1.54167763
49MP0001790_abnormal_immune_system1.54167763
50MP0005167_abnormal_blood-brain_barrier1.53811240
51MP0005671_abnormal_response_to1.52600539
52MP0002127_abnormal_cardiovascular_syste1.50986227
53MP0004085_abnormal_heartbeat1.50348043
54MP0000015_abnormal_ear_pigmentation1.47899161
55MP0010630_abnormal_cardiac_muscle1.47744308
56MP0003941_abnormal_skin_development1.46820475
57MP0005253_abnormal_eye_physiology1.46505720
58MP0009785_altered_susceptibility_to1.45935436
59MP0004742_abnormal_vestibular_system1.41307265
60MP0006072_abnormal_retinal_apoptosis1.39625872
61MP0001853_heart_inflammation1.37900175
62MP0006292_abnormal_olfactory_placode1.36780918
63MP0000759_abnormal_skeletal_muscle1.33871704
64MP0009745_abnormal_behavioral_response1.32563534
65MP0000343_altered_response_to1.32237701
66MP0002419_abnormal_innate_immunity1.30215696
67MP0006138_congestive_heart_failure1.27565447
68MP0003136_yellow_coat_color1.26672027
69MP0005409_darkened_coat_color1.21275377
70MP0002269_muscular_atrophy1.20659929
71MP0005171_absent_coat_pigmentation1.20307838
72MP0010678_abnormal_skin_adnexa1.19511956
73MP0003724_increased_susceptibility_to1.18922140
74MP0005000_abnormal_immune_tolerance1.17303730
75MP0005075_abnormal_melanosome_morpholog1.14656492
76MP0002272_abnormal_nervous_system1.14050757
77MP0001529_abnormal_vocalization1.14004495
78MP0009046_muscle_twitch1.12135511
79MP0004924_abnormal_behavior1.10102666
80MP0005386_behavior/neurological_phenoty1.10102666
81MP0002332_abnormal_exercise_endurance1.10023827
82MP0010386_abnormal_urinary_bladder1.09454618
83MP0005448_abnormal_energy_balance1.08168422
84MP0003950_abnormal_plasma_membrane1.07635715
85MP0002452_abnormal_antigen_presenting1.06536503
86MP0004381_abnormal_hair_follicle1.05323122
87MP0005332_abnormal_amino_acid1.04455622
88MP0001324_abnormal_eye_pigmentation1.03074503
89MP0000631_abnormal_neuroendocrine_gland1.02860887
90MP0001800_abnormal_humoral_immune1.02722090
91MP0005025_abnormal_response_to1.02647106
92MP0002723_abnormal_immune_serum1.02176782
93MP0008260_abnormal_autophagy1.01559724
94MP0008877_abnormal_DNA_methylation1.01255933
95MP0004782_abnormal_surfactant_physiolog1.00338422
96MP0002138_abnormal_hepatobiliary_system0.99861539
97MP0000026_abnormal_inner_ear0.98600725
98MP0002254_reproductive_system_inflammat0.95412951
99MP0002735_abnormal_chemical_nociception0.94699718
100MP0003436_decreased_susceptibility_to0.93949188
101MP0002163_abnormal_gland_morphology0.92952033
102MP0000372_irregular_coat_pigmentation0.92857061
103MP0008995_early_reproductive_senescence0.92356908
104MP0000538_abnormal_urinary_bladder0.91975397
105MP0003763_abnormal_thymus_physiology0.91955574
106MP0001819_abnormal_immune_cell0.90470571
107MP0005266_abnormal_metabolism0.90235739
108MP0001346_abnormal_lacrimal_gland0.90115489
109MP0005666_abnormal_adipose_tissue0.89762724
110MP0000013_abnormal_adipose_tissue0.89548678
111MP0002064_seizures0.89458028
112MP0001486_abnormal_startle_reflex0.89365499
113MP0009764_decreased_sensitivity_to0.88480798
114MP0002638_abnormal_pupillary_reflex0.88185148
115MP0002420_abnormal_adaptive_immunity0.88030560
116MP0002557_abnormal_social/conspecific_i0.87542511
117MP0002098_abnormal_vibrissa_morphology0.86193233
118MP0005187_abnormal_penis_morphology0.86002164
119MP0005389_reproductive_system_phenotype0.85754720
120MP0002998_abnormal_bone_remodeling0.84736629
121MP0005165_increased_susceptibility_to0.84531997
122MP0002822_catalepsy0.84293962
123MP0005174_abnormal_tail_pigmentation0.84116489
124MP0004133_heterotaxia0.82233591
125MP0005310_abnormal_salivary_gland0.81762094
126MP0001919_abnormal_reproductive_system0.81527026
127MP0003878_abnormal_ear_physiology0.81373439
128MP0005377_hearing/vestibular/ear_phenot0.81373439
129MP0010329_abnormal_lipoprotein_level0.81349749
130MP0002572_abnormal_emotion/affect_behav0.81075686
131MP0005195_abnormal_posterior_eye0.80992729
132MP0000647_abnormal_sebaceous_gland0.80992573
133MP0002095_abnormal_skin_pigmentation0.80657043
134MP0000230_abnormal_systemic_arterial0.79932625
135MP0000767_abnormal_smooth_muscle0.79646464
136MP0002876_abnormal_thyroid_physiology0.78479318
137MP0005451_abnormal_body_composition0.77665548
138MP0002067_abnormal_sensory_capabilities0.76701307
139MP0002132_abnormal_respiratory_system0.76430638
140MP0001440_abnormal_grooming_behavior0.74901766
141MP0001873_stomach_inflammation0.74412467
142MP0002234_abnormal_pharynx_morphology0.73955264
143MP0001502_abnormal_circadian_rhythm0.73049657
144MP0003183_abnormal_peptide_metabolism0.72310580
145MP0003279_aneurysm0.72035248
146MP0005379_endocrine/exocrine_gland_phen0.71452034
147MP0006082_CNS_inflammation0.71001842
148MP0000579_abnormal_nail_morphology0.70540727
149MP0003045_fibrosis0.68480928
150MP0000685_abnormal_immune_system0.67743236
151MP0001984_abnormal_olfaction0.66487548
152MP0000747_muscle_weakness0.66232776
153MP0002933_joint_inflammation0.65075186
154MP0005645_abnormal_hypothalamus_physiol0.64399080
155MP0002108_abnormal_muscle_morphology0.62603253
156MP0002693_abnormal_pancreas_physiology0.62577942
157MP0002405_respiratory_system_inflammati0.61441671
158MP0005646_abnormal_pituitary_gland0.61422333
159MP0006036_abnormal_mitochondrial_physio0.58982906

Predicted human phenotypes

RankGene SetZ-score
1Calf muscle hypertrophy (HP:0008981)5.58640137
2Ventricular tachycardia (HP:0004756)5.39148243
3Sudden death (HP:0001699)5.32337001
4Muscle hypertrophy of the lower extremities (HP:0008968)5.20695738
5Atrial fibrillation (HP:0005110)4.93456998
6Exercise-induced myalgia (HP:0003738)4.60972462
7Primary atrial arrhythmia (HP:0001692)4.51636113
8Subaortic stenosis (HP:0001682)4.37736716
9Abnormality of the left ventricular outflow tract (HP:0011103)4.37736716
10Supraventricular tachycardia (HP:0004755)4.29410670
11Abnormality of the calf musculature (HP:0001430)4.16408545
12Supraventricular arrhythmia (HP:0005115)4.13355139
13Syncope (HP:0001279)3.87522724
14Pancreatic cysts (HP:0001737)3.86039121
15Lipoatrophy (HP:0100578)3.84100005
16Congenital stationary night blindness (HP:0007642)3.82341288
17Exercise-induced muscle cramps (HP:0003710)3.68800924
18Muscle fiber splitting (HP:0003555)3.63086752
19True hermaphroditism (HP:0010459)3.62818427
20Distal lower limb muscle weakness (HP:0009053)3.58720721
21Type II lissencephaly (HP:0007260)3.58704722
22Prolonged QT interval (HP:0001657)3.53307034
23Molar tooth sign on MRI (HP:0002419)3.46699181
24Abnormality of midbrain morphology (HP:0002418)3.46699181
25Right ventricular cardiomyopathy (HP:0011663)3.41315578
26Dilated cardiomyopathy (HP:0001644)3.31462947
27Pancreatic fibrosis (HP:0100732)3.27458397
28Nephronophthisis (HP:0000090)3.26402382
29Abnormality of the renal cortex (HP:0011035)3.19734860
30Hyporeflexia of lower limbs (HP:0002600)3.06017084
31EMG: myopathic abnormalities (HP:0003458)3.05777952
32Retrobulbar optic neuritis (HP:0100654)3.02986593
33Optic neuritis (HP:0100653)3.02986593
34Palpitations (HP:0001962)2.99502922
35Congenital, generalized hypertrichosis (HP:0004540)2.92140761
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.91996759
37Myoglobinuria (HP:0002913)2.87902524
38Left ventricular hypertrophy (HP:0001712)2.87539745
39Furrowed tongue (HP:0000221)2.85952062
40Inability to walk (HP:0002540)2.85837977
41Abnormality of the renal medulla (HP:0100957)2.83641016
42Bundle branch block (HP:0011710)2.83626685
43Heart block (HP:0012722)2.81533220
44Concave nail (HP:0001598)2.75701369
45Abnormal EKG (HP:0003115)2.68479563
46Abnormal atrioventricular conduction (HP:0005150)2.64682730
47Decreased circulating renin level (HP:0003351)2.61818703
48Recurrent abscess formation (HP:0002722)2.60895475
49Renal cortical cysts (HP:0000803)2.60693441
50Hyperventilation (HP:0002883)2.60321109
51Asymmetric septal hypertrophy (HP:0001670)2.58582278
52Tubular atrophy (HP:0000092)2.54451457
53Ventricular arrhythmia (HP:0004308)2.52597480
54Chromsome breakage (HP:0040012)2.48865728
55Pulmonary artery stenosis (HP:0004415)2.42254468
56Orchitis (HP:0100796)2.41407958
57Eczematoid dermatitis (HP:0000976)2.41366410
58Severe muscular hypotonia (HP:0006829)2.39391297
59Cystic liver disease (HP:0006706)2.38181696
60Attenuation of retinal blood vessels (HP:0007843)2.38068875
61Congenital hepatic fibrosis (HP:0002612)2.37983998
62Distal lower limb amyotrophy (HP:0008944)2.37287022
63Increased connective tissue (HP:0009025)2.37092326
64Polydipsia (HP:0001959)2.33320877
65Abnormal drinking behavior (HP:0030082)2.33320877
66Pendular nystagmus (HP:0012043)2.28706698
67Lipid accumulation in hepatocytes (HP:0006561)2.27817782
68Duplicated collecting system (HP:0000081)2.27342996
69Acute necrotizing encephalopathy (HP:0006965)2.25122581
70Areflexia of lower limbs (HP:0002522)2.24546814
71Muscle fiber inclusion bodies (HP:0100299)2.24423271
72Atrioventricular block (HP:0001678)2.23401437
73Increased hepatocellular lipid droplets (HP:0006565)2.21844909
74Cerebellar dysplasia (HP:0007033)2.21564349
75Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.20593483
76Aplasia cutis congenita (HP:0001057)2.18333213
77Abnormality of the renal collecting system (HP:0004742)2.16185919
78Optic disc pallor (HP:0000543)2.15958019
79Abnormal mitochondria in muscle tissue (HP:0008316)2.15017369
80Gingivitis (HP:0000230)2.13982093
81Recurrent bacterial skin infections (HP:0005406)2.13561273
82Medial flaring of the eyebrow (HP:0010747)2.13163140
83Rhabdomyolysis (HP:0003201)2.13152584
84Congenital sensorineural hearing impairment (HP:0008527)2.10491539
85Myotonia (HP:0002486)2.10310257
86Type 1 muscle fiber predominance (HP:0003803)2.10286930
87Abnormality of alanine metabolism (HP:0010916)2.09196615
88Hyperalaninemia (HP:0003348)2.09196615
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09196615
90Erythroderma (HP:0001019)2.07787069
91Sclerocornea (HP:0000647)2.07351404
92Abnormality of secondary sexual hair (HP:0009888)2.05732006
93Abnormality of the axillary hair (HP:0100134)2.05732006
94Decreased central vision (HP:0007663)2.02363428
95Conjunctival hamartoma (HP:0100780)2.02352377
96Hepatic necrosis (HP:0002605)2.02015959
97Rimmed vacuoles (HP:0003805)2.01155475
98Myositis (HP:0100614)2.01089733
99Lissencephaly (HP:0001339)2.00945846
100Palmoplantar keratoderma (HP:0000982)2.00628752
101Ventricular fibrillation (HP:0001663)1.98770695
102Limb dystonia (HP:0002451)1.98118158
103Clumsiness (HP:0002312)1.97413653
104Basal ganglia calcification (HP:0002135)1.96180151
105Prostate neoplasm (HP:0100787)1.95199018
106Insulin-resistant diabetes mellitus (HP:0000831)1.94619804
107Mitochondrial inheritance (HP:0001427)1.93748172
108Acute encephalopathy (HP:0006846)1.91380055
109Abnormality of the endocardium (HP:0004306)1.91270808
110Abolished electroretinogram (ERG) (HP:0000550)1.91100788
111Anencephaly (HP:0002323)1.90666512
112Febrile seizures (HP:0002373)1.90360660
113Abnormal biliary tract physiology (HP:0012439)1.90105620
114Bile duct proliferation (HP:0001408)1.90105620
115Keratoconjunctivitis sicca (HP:0001097)1.89892540
116Hypothermia (HP:0002045)1.89677300
117Retinal dysplasia (HP:0007973)1.89654146
118Hyperkalemia (HP:0002153)1.89176585
119Keratoconus (HP:0000563)1.88216099
120Increased corneal curvature (HP:0100692)1.88216099
121Lip pit (HP:0100267)1.88112600
122Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.87700139
123Exercise intolerance (HP:0003546)1.86964811
124Distal arthrogryposis (HP:0005684)1.86395073
125Cerebral palsy (HP:0100021)1.85690713
126Weak cry (HP:0001612)1.85494164
127Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85275612
128Abnormality of the nasal septum (HP:0000419)1.85236325
129Testicular atrophy (HP:0000029)1.85231283
130Abnormality of the right ventricle (HP:0001707)1.85196078
131Bilateral microphthalmos (HP:0007633)1.82331732
132Aplasia/Hypoplasia of the tibia (HP:0005772)1.81805530
133Exertional dyspnea (HP:0002875)1.81477973
134Abnormality of the neuromuscular junction (HP:0003398)1.80721694
135Fatigable weakness (HP:0003473)1.80721694
136Nemaline bodies (HP:0003798)1.79806892
137Keratoconjunctivitis (HP:0001096)1.79444296
138Osteomalacia (HP:0002749)1.79343876
139Large for gestational age (HP:0001520)1.79182639
140Abnormality of proline metabolism (HP:0010907)1.79118375
141Hydroxyprolinuria (HP:0003080)1.79118375
142Male pseudohermaphroditism (HP:0000037)1.78765138
143Aplasia/Hypoplasia of the fovea (HP:0008060)1.78651372
144Hypoplasia of the fovea (HP:0007750)1.78651372
145Polyuria (HP:0000103)1.77955149
146Progressive inability to walk (HP:0002505)1.77776789
147Abnormal rod and cone electroretinograms (HP:0008323)1.77077336
148Bradycardia (HP:0001662)1.76851862
149Difficulty running (HP:0009046)1.76622189
150Ketosis (HP:0001946)1.76475201
151Progressive macrocephaly (HP:0004481)1.76468558
152White forelock (HP:0002211)1.76107182
153Premature loss of primary teeth (HP:0006323)1.75427263
154Hypoplastic left heart (HP:0004383)1.73526919
155Patchy hypopigmentation of hair (HP:0011365)1.73415061
156Hemiparesis (HP:0001269)1.73242849
157Malignant hyperthermia (HP:0002047)1.72780335
158Neck muscle weakness (HP:0000467)1.72158961
159Renal Fanconi syndrome (HP:0001994)1.72037635
160Oligomenorrhea (HP:0000876)1.71124541
161Optic nerve hypoplasia (HP:0000609)1.70826002
162Abnormality of the pons (HP:0007361)1.70034282
163Chronic mucocutaneous candidiasis (HP:0002728)1.69939002
164Recurrent cutaneous fungal infections (HP:0011370)1.69939002
165Abnormal finger flexion creases (HP:0006143)1.69803416
166Absent phalangeal crease (HP:0006109)1.69742919
167Hepatocellular necrosis (HP:0001404)1.69402377
168Progressive cerebellar ataxia (HP:0002073)1.69182137
169Generalized aminoaciduria (HP:0002909)1.67585459
170Type 2 muscle fiber atrophy (HP:0003554)1.67454868
171Chronic hepatic failure (HP:0100626)1.67308103
172Aplasia/Hypoplasia of the tongue (HP:0010295)1.66052530
173Recurrent fungal infections (HP:0002841)1.65972840
174Increased CSF lactate (HP:0002490)1.65330952

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.77217900
2IRAK33.67864549
3ACVR1B3.34458801
4ZAK3.05454652
5MAP3K142.98268607
6OBSCN2.85633696
7TTN2.63737137
8INSRR2.63184242
9IRAK42.58331924
10GRK72.45859895
11PHKG12.42421459
12PHKG22.42421459
13TXK2.34043645
14TLK12.23134616
15WNK32.16347310
16BLK2.09039328
17CASK2.07287103
18MUSK1.94736002
19MARK11.81360360
20PINK11.80194988
21STK241.80057668
22PIK3CA1.78590974
23MYLK1.77498975
24TGFBR11.75015344
25MAP4K21.74426858
26EPHA31.72826340
27LMTK21.70444569
28TGFBR21.64734411
29OXSR11.61676499
30WNK41.60286660
31EIF2AK21.58744358
32IRAK11.57238181
33DMPK1.45821973
34ADRBK11.45110304
35DAPK21.40066007
36IKBKB1.35741937
37PKN11.34830021
38SIK31.33112953
39IKBKE1.27443576
40SGK21.26167589
41JAK11.25834382
42DYRK21.24487646
43STK391.20444038
44BMPR21.20354109
45MAPKAPK31.13997852
46TNIK1.12985417
47YES11.12313062
48NLK1.10489616
49PNCK1.09615262
50JAK31.06378962
51IRAK21.06246133
52STK38L1.02889853
53TYK21.02547607
54AKT31.01588729
55TIE11.00852565
56CHUK1.00830066
57TBK11.00603761
58TAF11.00145661
59NEK90.95432574
60ADRBK20.94325152
61TRPM70.94250960
62PIK3CG0.93259715
63NUAK10.91640976
64MAPK120.89265435
65PRKAA20.89176940
66PRKCE0.87204591
67MAP3K120.86805006
68MKNK20.85906312
69STK40.84703951
70BMPR1B0.83755870
71MAP3K40.83485915
72MAP2K30.83015211
73MAPK150.82097068
74TAOK30.81914476
75KIT0.79396610
76CAMK40.78389333
77MAPK70.78033570
78CDK30.77475071
79TAOK20.76669185
80TEC0.76588615
81NME10.76453362
82MAP2K40.76418802
83MAP2K60.75704097
84PRKCG0.73900624
85VRK10.70317637
86PDK20.69311018
87CAMK2D0.68970974
88MAP3K110.67725920
89MAP4K10.67579661
90EPHB20.67363364
91PAK30.67156816
92SGK30.66659410
93CAMK2A0.64791250
94GRK10.64523865
95PLK40.63708426
96RPS6KA60.63412748
97CDC42BPA0.62853897
98RPS6KL10.62639137
99RPS6KC10.62639137
100ERBB30.62535291
101NEK60.61727966
102SYK0.60206971
103MAP3K50.59942615
104FER0.59692972
105CDK80.56703992
106MAP2K70.55919525
107PRKAA10.52213835
108PRKCI0.51465512
109PDK40.49636120
110PDK30.49636120
111BTK0.49162511
112CDK190.47420196
113MAPK130.45241317
114MAP2K20.45025636
115SGK4940.44539654
116SGK2230.44539654
117PRKCZ0.44502622
118HCK0.43710679
119PRKD10.43679410
120SIK10.42648002
121RPS6KA50.42105993
122EPHB10.41728592
123MAP3K30.41377228
124FGFR30.41176718
125PRKCD0.40792345
126PRKG10.40496208
127SGK10.40260129
128CSNK1A10.39877961
129CSNK1G10.39708548
130MAP2K10.39369472
131PRKACA0.39323759
132MATK0.39121992
133CSNK1G20.38853818
134STK160.38150569
135STK110.38016015
136CAMK1D0.37647004
137MAPKAPK20.37587345
138FLT30.36760399
139LYN0.35996782
140BCKDK0.35926657
141MAPKAPK50.34448709
142MAP3K90.33133395
143RPS6KB10.32117885
144MAP3K70.30855187
145PRKCQ0.30638346
146FGFR20.30348627
147MST40.28918224
148DYRK30.28059224
149GRK60.27916438
150MAPK40.27207137
151PTK2B0.26525577
152WEE10.26424653
153CAMKK20.25915255
154PRKACB0.25666427

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.33657262
2Dilated cardiomyopathy_Homo sapiens_hsa054143.08792399
3Linoleic acid metabolism_Homo sapiens_hsa005912.86752865
4Nitrogen metabolism_Homo sapiens_hsa009102.80377141
5Cardiac muscle contraction_Homo sapiens_hsa042602.77279566
6Tryptophan metabolism_Homo sapiens_hsa003802.63095657
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.40192674
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.32981624
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.30534295
10Oxidative phosphorylation_Homo sapiens_hsa001902.24963888
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.04823145
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02888165
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.98761626
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.96316348
15Parkinsons disease_Homo sapiens_hsa050121.87384563
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.87143888
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.85505396
18Graft-versus-host disease_Homo sapiens_hsa053321.82506793
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.81919973
20Measles_Homo sapiens_hsa051621.77876323
21Circadian rhythm_Homo sapiens_hsa047101.77465699
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.75315842
23Leishmaniasis_Homo sapiens_hsa051401.72846425
24Butanoate metabolism_Homo sapiens_hsa006501.71824275
25Ether lipid metabolism_Homo sapiens_hsa005651.69195357
26Histidine metabolism_Homo sapiens_hsa003401.66799634
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.64634804
28Viral myocarditis_Homo sapiens_hsa054161.64081651
29Allograft rejection_Homo sapiens_hsa053301.62965685
30Osteoclast differentiation_Homo sapiens_hsa043801.62659746
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.62624415
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.62369603
33Other glycan degradation_Homo sapiens_hsa005111.62289173
34Alzheimers disease_Homo sapiens_hsa050101.51030775
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.49064948
36Selenocompound metabolism_Homo sapiens_hsa004501.47488197
37Caffeine metabolism_Homo sapiens_hsa002321.46366262
38Autoimmune thyroid disease_Homo sapiens_hsa053201.43289388
39Protein export_Homo sapiens_hsa030601.41415232
40Chemical carcinogenesis_Homo sapiens_hsa052041.36619641
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33325419
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33231800
43Nicotine addiction_Homo sapiens_hsa050331.33223002
44Rheumatoid arthritis_Homo sapiens_hsa053231.33090472
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31143743
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28614395
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21817993
48Influenza A_Homo sapiens_hsa051641.20982544
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.20845788
50Primary immunodeficiency_Homo sapiens_hsa053401.19279594
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19205065
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.17428965
53Huntingtons disease_Homo sapiens_hsa050161.17077363
54Sulfur metabolism_Homo sapiens_hsa009201.15577541
55TNF signaling pathway_Homo sapiens_hsa046681.13882231
56Hematopoietic cell lineage_Homo sapiens_hsa046401.12104140
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12019402
58Arachidonic acid metabolism_Homo sapiens_hsa005901.08310373
59Basal transcription factors_Homo sapiens_hsa030221.06365029
60Toxoplasmosis_Homo sapiens_hsa051451.05481281
61SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05010154
62Calcium signaling pathway_Homo sapiens_hsa040201.04145846
63RNA polymerase_Homo sapiens_hsa030201.01015414
64Peroxisome_Homo sapiens_hsa041461.00497206
65Herpes simplex infection_Homo sapiens_hsa051681.00090735
66Mineral absorption_Homo sapiens_hsa049780.98324185
67Taste transduction_Homo sapiens_hsa047420.95926160
68Serotonergic synapse_Homo sapiens_hsa047260.95565610
69Propanoate metabolism_Homo sapiens_hsa006400.93240391
70Tuberculosis_Homo sapiens_hsa051520.89371860
71Fatty acid degradation_Homo sapiens_hsa000710.89266700
72Starch and sucrose metabolism_Homo sapiens_hsa005000.89234476
73Ribosome_Homo sapiens_hsa030100.88690372
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.87454082
75Arginine and proline metabolism_Homo sapiens_hsa003300.86824012
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86366534
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.86111210
78Retinol metabolism_Homo sapiens_hsa008300.85010793
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84799067
80Fatty acid biosynthesis_Homo sapiens_hsa000610.83732533
81Staphylococcus aureus infection_Homo sapiens_hsa051500.82556071
82Fanconi anemia pathway_Homo sapiens_hsa034600.80751515
83Vitamin digestion and absorption_Homo sapiens_hsa049770.76824547
84Olfactory transduction_Homo sapiens_hsa047400.76181732
85Asthma_Homo sapiens_hsa053100.75883712
86Apoptosis_Homo sapiens_hsa042100.74684538
87Glycerolipid metabolism_Homo sapiens_hsa005610.74338029
88Type II diabetes mellitus_Homo sapiens_hsa049300.74110234
89Collecting duct acid secretion_Homo sapiens_hsa049660.72440748
90Chemokine signaling pathway_Homo sapiens_hsa040620.72316144
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71894183
92Sphingolipid metabolism_Homo sapiens_hsa006000.71190180
93Legionellosis_Homo sapiens_hsa051340.68497753
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68205373
95Fatty acid elongation_Homo sapiens_hsa000620.68086183
96Phototransduction_Homo sapiens_hsa047440.67728481
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.66941746
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66174120
99ABC transporters_Homo sapiens_hsa020100.65809091
100Malaria_Homo sapiens_hsa051440.65791629
101Regulation of autophagy_Homo sapiens_hsa041400.65594639
102Circadian entrainment_Homo sapiens_hsa047130.64749468
103Insulin resistance_Homo sapiens_hsa049310.64209317
104Fat digestion and absorption_Homo sapiens_hsa049750.60713625
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60674645
106GABAergic synapse_Homo sapiens_hsa047270.60615073
107Pertussis_Homo sapiens_hsa051330.59747872
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57983915
109Metabolic pathways_Homo sapiens_hsa011000.57806189
110Lysosome_Homo sapiens_hsa041420.56462198
111Phagosome_Homo sapiens_hsa041450.56321224
112Steroid biosynthesis_Homo sapiens_hsa001000.55037715
113Glutamatergic synapse_Homo sapiens_hsa047240.55032706
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54110551
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.53557431
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52334914
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52184539
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51732621
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51218396
120Type I diabetes mellitus_Homo sapiens_hsa049400.51071292
121B cell receptor signaling pathway_Homo sapiens_hsa046620.50979304
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50954942
123African trypanosomiasis_Homo sapiens_hsa051430.50288783
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49883920
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49375102
126Salmonella infection_Homo sapiens_hsa051320.47982069
127Inositol phosphate metabolism_Homo sapiens_hsa005620.45987892
128cAMP signaling pathway_Homo sapiens_hsa040240.45643787
129Dorso-ventral axis formation_Homo sapiens_hsa043200.45555055
130beta-Alanine metabolism_Homo sapiens_hsa004100.44710011
131Fatty acid metabolism_Homo sapiens_hsa012120.44560663
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44403800
133Notch signaling pathway_Homo sapiens_hsa043300.44250602
134FoxO signaling pathway_Homo sapiens_hsa040680.44241234
135Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43806892
136Morphine addiction_Homo sapiens_hsa050320.43152718
137Acute myeloid leukemia_Homo sapiens_hsa052210.43052321
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42443632
139One carbon pool by folate_Homo sapiens_hsa006700.42412020
140Prolactin signaling pathway_Homo sapiens_hsa049170.42305938
141Insulin secretion_Homo sapiens_hsa049110.42257902
142Lysine degradation_Homo sapiens_hsa003100.40519658
143Renin secretion_Homo sapiens_hsa049240.40359817
144Tyrosine metabolism_Homo sapiens_hsa003500.40334683
145Homologous recombination_Homo sapiens_hsa034400.40281916
146alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39883748
147Salivary secretion_Homo sapiens_hsa049700.39583148
148Purine metabolism_Homo sapiens_hsa002300.39190791
149MAPK signaling pathway_Homo sapiens_hsa040100.38173372
150Hedgehog signaling pathway_Homo sapiens_hsa043400.35173084
151Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34594288
152Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34334458
153HIF-1 signaling pathway_Homo sapiens_hsa040660.33349209
154Oxytocin signaling pathway_Homo sapiens_hsa049210.33229708
155Ovarian steroidogenesis_Homo sapiens_hsa049130.32962071

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